Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	desmosome	DSC1 DSC2 DSC3	4.82e-05	28	53	3	GO:0030057
GeneOntologyCellularComponent	microtubule minus-end	SVIL CAMSAP3	1.31e-04	7	53	2	GO:0036449
GeneOntologyCellularComponent	anchoring junction	ARHGAP22 ARHGAP24 PTPRA DSC1 DSC2 DSC3 SVIL CAMSAP3 PRKCG DMD	1.47e-04	976	53	10	GO:0070161
GeneOntologyCellularComponent	WASH complex	WASHC2C WASHC2A	6.48e-04	15	53	2	GO:0071203
GeneOntologyCellularComponent	cornified envelope	DSC1 DSC2 DSC3	7.16e-04	69	53	3	GO:0001533
MousePheno	increased total tissue mass	ESR1 DMD MSTN PTGS2 BDNF AFF4 RAI1	1.28e-04	364	44	7	MP:0012323
MousePheno	increased body weight	ESR1 DMD MSTN PTGS2 BDNF AFF4 RAI1	1.28e-04	364	44	7	MP:0001260
MousePheno	abnormal parental behavior	PTPRA ESR1 RORA CUX1 BDNF	1.40e-04	160	44	5	MP:0002068
MousePheno	increased hormone level	LARP4B ESR1 CAMSAP3 RORA IDE DMD PTGS2 BDNF RAI1	1.42e-04	641	44	9	MP:0014454
MousePheno	increased skeletal muscle weight	DMD MSTN	1.44e-04	6	44	2	MP:0010238
MousePheno	increased skeletal muscle fiber number	DMD MSTN	1.44e-04	6	44	2	MP:0009405
Domain	Desmosomal_cadherin	DSC1 DSC2 DSC3	7.49e-07	7	53	3	IPR009122
Domain	Cadherin_pro	DSC1 DSC2 DSC3	7.49e-07	7	53	3	PF08758
Domain	Cadherin_pro_dom	DSC1 DSC2 DSC3	1.20e-06	8	53	3	IPR014868
Domain	Cadherin_pro	DSC1 DSC2 DSC3	1.20e-06	8	53	3	SM01055
Domain	FAM21	WASHC2C WASHC2A	7.90e-06	2	53	2	IPR027308
Domain	FAM21/CAPZIP	WASHC2C WASHC2A	2.37e-05	3	53	2	IPR029341
Domain	CAP-ZIP_m	WASHC2C WASHC2A	2.37e-05	3	53	2	PF15255
Domain	Cadherin_cytoplasmic-dom	DSC1 DSC2 DSC3	4.75e-05	25	53	3	IPR000233
Domain	Cadherin_C	DSC1 DSC2 DSC3	4.75e-05	25	53	3	PF01049
Domain	Catenin_binding_dom	DSC1 DSC2 DSC3	7.48e-05	29	53	3	IPR027397
Domain	-	DSC1 DSC2 DSC3	7.48e-05	29	53	3	4.10.900.10
Domain	PH	ARHGAP22 ARHGAP24 ABR SH2B3 PLEKHA6	4.71e-04	229	53	5	PF00169
Domain	C2	SYT15B ABR ESYT1 PRKCG	5.19e-04	131	53	4	PF00168
Domain	G_TR_1	TUFM EFTUD2	6.04e-04	13	53	2	PS00301
Domain	C2	SYT15B ABR ESYT1 PRKCG	6.14e-04	137	53	4	SM00239
Domain	C2	SYT15B ABR ESYT1 PRKCG	7.02e-04	142	53	4	PS50004
Domain	RhoGAP	ARHGAP22 ARHGAP24 ABR	7.25e-04	62	53	3	SM00324
Domain	RhoGAP	ARHGAP22 ARHGAP24 ABR	7.60e-04	63	53	3	PF00620
Domain	RHOGAP	ARHGAP22 ARHGAP24 ABR	7.96e-04	64	53	3	PS50238
Domain	RhoGAP_dom	ARHGAP22 ARHGAP24 ABR	7.96e-04	64	53	3	IPR000198
Domain	-	ARHGAP22 ARHGAP24 ABR	7.96e-04	64	53	3	1.10.555.10
Domain	-	ARHGAP22 ARHGAP24 ABR SH2B3 PLEKHA6 RGS12	8.10e-04	391	53	6	2.30.29.30
Domain	-	SYT15B ABR ESYT1 PRKCG	8.20e-04	148	53	4	2.60.40.150
Domain	PH	ARHGAP22 ARHGAP24 ABR SH2B3 PLEKHA6	1.13e-03	278	53	5	SM00233
Domain	PH_DOMAIN	ARHGAP22 ARHGAP24 ABR SH2B3 PLEKHA6	1.15e-03	279	53	5	PS50003
Domain	PH_domain	ARHGAP22 ARHGAP24 ABR SH2B3 PLEKHA6	1.16e-03	280	53	5	IPR001849
Domain	EFTu-like_2	TUFM EFTUD2	1.17e-03	18	53	2	IPR004161
Domain	GTP_EFTU_D2	TUFM EFTUD2	1.17e-03	18	53	2	PF03144
Domain	G_TR_2	TUFM EFTUD2	1.17e-03	18	53	2	PS51722
Domain	C2_dom	SYT15B ABR ESYT1 PRKCG	1.20e-03	164	53	4	IPR000008
Domain	PH_dom-like	ARHGAP22 ARHGAP24 ABR SH2B3 PLEKHA6 RGS12	1.26e-03	426	53	6	IPR011993
Domain	TF_GTP-bd_dom	TUFM EFTUD2	1.31e-03	19	53	2	IPR000795
Domain	Rho_GTPase_activation_prot	ARHGAP22 ARHGAP24 ABR	2.00e-03	88	53	3	IPR008936
Domain	Transl_B-barrel	TUFM EFTUD2	2.65e-03	27	53	2	IPR009000
Domain	Cadherin_CS	DSC1 DSC2 DSC3	3.66e-03	109	53	3	IPR020894
Domain	CADHERIN_1	DSC1 DSC2 DSC3	4.05e-03	113	53	3	PS00232
Domain	Cadherin	DSC1 DSC2 DSC3	4.05e-03	113	53	3	PF00028
Domain	CADHERIN_2	DSC1 DSC2 DSC3	4.16e-03	114	53	3	PS50268
Domain	-	DSC1 DSC2 DSC3	4.16e-03	114	53	3	2.60.40.60
Domain	CA	DSC1 DSC2 DSC3	4.26e-03	115	53	3	SM00112
Domain	Cadherin-like	DSC1 DSC2 DSC3	4.36e-03	116	53	3	IPR015919
Domain	Cadherin	DSC1 DSC2 DSC3	4.58e-03	118	53	3	IPR002126
Domain	zf-C4	ESR1 RORA	7.55e-03	46	53	2	PF00105
Domain	Znf_hrmn_rcpt	ESR1 RORA	7.55e-03	46	53	2	IPR001628
Domain	Nuclear_hrmn_rcpt	ESR1 RORA	7.55e-03	46	53	2	IPR001723
Domain	NUCLEAR_REC_DBD_2	ESR1 RORA	7.55e-03	46	53	2	PS51030
Domain	NUCLEAR_REC_DBD_1	ESR1 RORA	7.55e-03	46	53	2	PS00031
Domain	ZnF_C4	ESR1 RORA	7.55e-03	46	53	2	SM00399
Domain	-	ESR1 RORA	7.87e-03	47	53	2	1.10.565.10
Domain	HOLI	ESR1 RORA	8.20e-03	48	53	2	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	ESR1 RORA	8.20e-03	48	53	2	IPR000536
Domain	Hormone_recep	ESR1 RORA	8.20e-03	48	53	2	PF00104
Pubmed	The influence of desmocollin 1-3 expression on prognosis after curative resection of colorectal liver metastases.	DSC1 DSC2 DSC3	3.74e-09	3	55	3	23975055
Pubmed	Compositionally different desmosomes in the various compartments of the human hair follicle.	DSC1 DSC2 DSC3	3.74e-09	3	55	3	9810708
Pubmed	Changing pattern of desmocollin 3 expression accompanies epidermal organisation during skin development.	DSC1 DSC2 DSC3	3.74e-09	3	55	3	9389456
Pubmed	Desmocollin switching in colorectal cancer.	DSC1 DSC2 DSC3	3.74e-09	3	55	3	17088906
Pubmed	Nomenclature of the desmosomal cadherins.	DSC1 DSC2 DSC3	3.73e-08	5	55	3	8486729
Pubmed	Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma.	DSC1 DSC2 DSC3	3.73e-08	5	55	3	22438068
Pubmed	Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse.	DSC1 DSC2 DSC3	7.46e-08	6	55	3	9404003
Pubmed	Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype.	DSC1 DSC2 DSC3	4.46e-07	10	55	3	12724416
Pubmed	Defining desmosomal plakophilin-3 interactions.	DSC1 DSC2 DSC3	8.15e-07	12	55	3	12707304
Pubmed	Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.	ESR1 IDE TF	1.06e-06	13	55	3	17192785
Pubmed	Assessment of splice variant-specific functions of desmocollin 1 in the skin.	DSC1 DSC2 DSC3	1.06e-06	13	55	3	14673151
Pubmed	Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice.	DSC1 DSC2 DSC3	1.68e-06	15	55	3	9847250
Pubmed	Desmocollin 3 is required for pre-implantation development of the mouse embryo.	DSC1 DSC2 DSC3	2.07e-06	16	55	3	16418220
Pubmed	Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese.	ESR1 IDE TF	2.07e-06	16	55	3	20880607
Pubmed	IRF6 and AP2A Interaction Regulates Epidermal Development.	DSC1 DSC2 DSC3	2.07e-06	16	55	3	29913133
Pubmed	RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis.	DSC1 DSC2 DSC3	2.07e-06	16	55	3	30689641
Pubmed	Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells.	DSC1 DSC3	2.46e-06	2	55	2	8884173
Pubmed	Muscle-bone interactions in dystrophin-deficient and myostatin-deficient mice.	DMD MSTN	2.46e-06	2	55	2	16078270
Pubmed	Genomic organization and amplification of the human desmosomal cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3.	DSC1 DSC3	2.46e-06	2	55	2	11027496
Pubmed	CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-α) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE).	ESR1 CUX1	2.46e-06	2	55	2	30964885
Pubmed	Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).	WASHC2C WASHC2A	2.46e-06	2	55	2	20827171
Pubmed	Quercetin exerts antidepressant and cardioprotective effects in estrogen receptor α-deficient female mice via BDNF-AKT/ERK1/2 signaling.	ESR1 BDNF	2.46e-06	2	55	2	33246157
Pubmed	FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.	WASHC2C WASHC2A	2.46e-06	2	55	2	36717248
Pubmed	Rai1 haploinsufficiency causes reduced Bdnf expression resulting in hyperphagia, obesity and altered fat distribution in mice and humans with no evidence of metabolic syndrome.	BDNF RAI1	2.46e-06	2	55	2	20663924
Pubmed	Biological scaffold-mediated delivery of myostatin inhibitor promotes a regenerative immune response in an animal model of Duchenne muscular dystrophy.	DMD MSTN	2.46e-06	2	55	2	30139748
Pubmed	Myostatin does not regulate cardiac hypertrophy or fibrosis.	DMD MSTN	2.46e-06	2	55	2	17336525
Pubmed	Cyclooxygenase-2 or tumor necrosis factor-α inhibitors attenuate the mechanotransductive effects of pulsed focused ultrasound to suppress mesenchymal stromal cell homing to healthy and dystrophic muscle.	DMD PTGS2	2.46e-06	2	55	2	25534849
Pubmed	Differential synthesis of type 1 and type 2 desmocollin mRNAs in human stratified epithelia.	DSC1 DSC2	2.46e-06	2	55	2	8507556
Pubmed	Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice.	DMD MSTN	2.46e-06	2	55	2	25304272
Pubmed	The desmocollins of human foreskin epidermis: identification and chromosomal assignment of a third gene and expression patterns of the three isoforms.	DSC1 DSC3	2.46e-06	2	55	2	7665906
Pubmed	Combination Antisense Treatment for Destructive Exon Skipping of Myostatin and Open Reading Frame Rescue of Dystrophin in Neonatal mdx Mice.	DMD MSTN	2.46e-06	2	55	2	25959011
Pubmed	Identification of a novel Rev-interacting cellular protein.	WASHC2C WASHC2A	2.46e-06	2	55	2	15847701
Pubmed	Maintenance of Mouse Gustatory Terminal Field Organization Is Dependent on BDNF at Adulthood.	NDOR1 BDNF	2.46e-06	2	55	2	29954852
Pubmed	Central depletion of brain-derived neurotrophic factor in mice results in high bone mass and metabolic phenotype.	ESR1 BDNF	2.46e-06	2	55	2	23011922
Pubmed	Inhibition of myostatin reverses muscle fibrosis through apoptosis.	DMD MSTN	2.46e-06	2	55	2	22685331
Pubmed	BDNF is required for taste axon regeneration following unilateral chorda tympani nerve section.	NDOR1 BDNF	2.46e-06	2	55	2	28347764
Pubmed	Muscle regeneration in the prolonged absence of myostatin.	DMD MSTN	2.46e-06	2	55	2	15699335
Pubmed	The interaction of combined effects of the BDNF and PRKCG genes and negative life events in major depressive disorder.	PRKCG BDNF	2.46e-06	2	55	2	26921055
Pubmed	Loss of myostatin attenuates severity of muscular dystrophy in mdx mice.	DMD MSTN	2.46e-06	2	55	2	12447939
Pubmed	Myostatin genetic inactivation inhibits myogenesis by muscle-derived stem cells in vitro but not when implanted in the mdx mouse muscle.	DMD MSTN	2.46e-06	2	55	2	23295128
Pubmed	Estrogen regulates the development of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus.	ESR1 BDNF	2.46e-06	2	55	2	11923430
Pubmed	Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy.	DMD MSTN	2.46e-06	2	55	2	21507246
Pubmed	Glucocorticoids counteract hypertrophic effects of myostatin inhibition in dystrophic muscle.	DMD MSTN	2.46e-06	2	55	2	31830002
Pubmed	Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico.	ARHGAP22 ARHGAP24	7.36e-06	3	55	2	15254788
Pubmed	Early adolescent Rai1 reactivation reverses transcriptional and social interaction deficits in a mouse model of Smith-Magenis syndrome.	NDOR1 RAI1	7.36e-06	3	55	2	30275311
Pubmed	Assignment of the human genes for desmocollin 3 (DSC3) and desmocollin 4 (DSC4) to chromosome 18q12.	DSC2 DSC3	7.36e-06	3	55	2	7774948
Pubmed	Stable transfection of estrogen receptor-alpha suppresses expression of cyclooxygenase-2 and vascular endothelial growth factor-C in MDA-MB-231 breast cancer cells.	ESR1 PTGS2	7.36e-06	3	55	2	20819530
Pubmed	cDNA cloning and expression of a novel human desmocollin.	DSC2 DSC3	7.36e-06	3	55	2	7929347
Pubmed	Structure and function of desmosomal proteins and their role in development and disease.	DSC2 DSC3	7.36e-06	3	55	2	14523549
Pubmed	Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy.	DMD PTGS2	7.36e-06	3	55	2	25320234
Pubmed	Taste Bud-Derived BDNF Is Required to Maintain Normal Amounts of Innervation to Adult Taste Buds.	NDOR1 BDNF	7.36e-06	3	55	2	26730405
Pubmed	A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation.	DMD RGS12	7.36e-06	3	55	2	31408461
Pubmed	Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton.	SVIL DMD	7.36e-06	3	55	2	12711699
Pubmed	Selective association of peroxiredoxin 1 with genomic DNA and COX-2 upstream promoter elements in estrogen receptor negative breast cancer cells.	ESR1 PTGS2	7.36e-06	3	55	2	20631257
Pubmed	Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice.	ESR1 BDNF	7.36e-06	3	55	2	33352311
Pubmed	Temporal dissection of Rai1 function reveals brain-derived neurotrophic factor as a potential therapeutic target for Smith-Magenis syndrome.	NDOR1 RAI1	1.47e-05	4	55	2	34463714
Pubmed	Expression of estrogen receptors (α, β), cyclooxygenase-2 and aromatase in normal endometrium and endometrioid cancer of uterus.	ESR1 PTGS2	1.47e-05	4	55	2	23625281
Pubmed	Plakoglobin as a regulator of desmocollin gene expression.	DSC2 DSC3	1.47e-05	4	55	2	23652796
Pubmed	Gamma-sarcoglycan is required for the response of archvillin to mechanical stimulation in skeletal muscle.	SVIL DMD	1.47e-05	4	55	2	25605665
Pubmed	Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation.	KMT5B DMD	1.47e-05	4	55	2	26669898
Pubmed	Smith-Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling.	BDNF RAI1	1.47e-05	4	55	2	37956053
Pubmed	Alteration of cerebellar neurotropin messenger ribonucleic acids and the lack of thyroid hormone receptor augmentation by staggerer-type retinoic acid receptor-related orphan receptor-alpha mutation.	RORA BDNF	1.47e-05	4	55	2	17218417
Pubmed	COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer.	ESR1 PTGS2	1.47e-05	4	55	2	21078168
Pubmed	Altered expression of ERs, aromatase, and COX2 connected to estrogen action in type 1 endometrial cancer biology.	ESR1 PTGS2	1.47e-05	4	55	2	23873111
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CPAMD8 ABR CAMSAP3 PISD IDE SSPOP CRAMP1 SLC2A11 CUX1 AFF4 RAI1	1.80e-05	1489	55	11	28611215
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ARHGAP24 ABR SVIL CAMSAP3 PRKCG CUX1 AFF4 RAI1 EFTUD2	1.87e-05	963	55	9	28671696
Pubmed	Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP).	DSC2 DSC3	2.45e-05	5	55	2	1889810
Pubmed	PKCα integrates spatiotemporally distinct Ca2+ and autocrine BDNF signaling to facilitate synaptic plasticity.	PRKCG BDNF	2.45e-05	5	55	2	30013171
Pubmed	Inflammatory status influences aromatase and steroid receptor expression in endometriosis.	ESR1 PTGS2	2.45e-05	5	55	2	18048499
Pubmed	Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ.	DMD MSTN	2.45e-05	5	55	2	27148972
Pubmed	Mighty is a novel promyogenic factor in skeletal myogenesis.	DMD MSTN	2.45e-05	5	55	2	18255059
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	RELCH PTPRA DSC2 DSC3 PLEKHA6 RGS12 SEMA4C	3.11e-05	569	55	7	30639242
Pubmed	Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.	TF BDNF	3.67e-05	6	55	2	18813964
Pubmed	Supervillin associates with androgen receptor and modulates its transcriptional activity.	ESR1 SVIL	3.67e-05	6	55	2	11792840
Pubmed	Downregulation of splicing regulator RBFOX1 compromises visual depth perception.	RBPMS NDOR1	3.67e-05	6	55	2	30001398
Pubmed	Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18.	DSC2 DSC3	3.67e-05	6	55	2	7959727
Pubmed	Wdr47 Controls Neuronal Polarization through the Camsap Family Microtubule Minus-End-Binding Proteins.	CAMSAP3 CUX1	5.13e-05	7	55	2	32320668
Pubmed	RIF-1, a novel nuclear receptor corepressor that associates with the nuclear matrix.	ESR1 RORA	5.13e-05	7	55	2	17455211
Pubmed	ANO1/TMEM16A regulates process maturation in radial glial cells in the developing brain.	CUX1 BDNF	5.13e-05	7	55	2	31147466
Pubmed	The Long Noncoding RNA Pnky Is a Trans-acting Regulator of Cortical Development In Vivo.	NDOR1 CUX1	5.13e-05	7	55	2	31112699
Pubmed	Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation.	KMT5B ESR1	5.13e-05	7	55	2	24101509
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	DSC2 DSC3 ESYT1 PLEKHA6 DMD SEMA4C	5.33e-05	421	55	6	36976175
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	WASHC2C ESYT1 SVIL NOB1 CAMSAP3 CEP41 WASHC2A RGS12	5.57e-05	853	55	8	28718761
Pubmed	A FAM21-containing WASH complex regulates retromer-dependent sorting.	WASHC2C WASHC2A	6.83e-05	8	55	2	19922874
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	LARP4B DSC2 DSC3 SVIL EFTUD2	7.38e-05	274	55	5	34244482
Pubmed	Purkinje Cell Degeneration and Motor Coordination Deficits in a New Mouse Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay.	RORA BDNF	8.78e-05	9	55	2	28588446
Pubmed	Genetic modifiers of muscular dystrophy: implications for therapy.	DMD MSTN	8.78e-05	9	55	2	16916601
Pubmed	IRX3/5 regulate mitotic chromatid segregation and limb bud shape.	ESR1 CUX1	1.10e-04	10	55	2	32907847
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	DSC1 DSC3 GBE1 IDE DMD	1.20e-04	304	55	5	32235678
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	ARHGAP22 WASHC2C DSC2 KMT5B CAMSAP3 CEP41 GBE1 IDE WASHC2A	1.33e-04	1242	55	9	30973865
Pubmed	Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.	DSC1 DSC2	1.34e-04	11	55	2	11790773
Pubmed	Expression of the mouse PR domain protein Prdm8 in the developing central nervous system.	PRKCG CUX1	1.34e-04	11	55	2	19616129
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	LARP4B DSC1 DSC3 ESYT1 SVIL NOB1 PISD TUFM EFTUD2	1.45e-04	1257	55	9	36526897
Pubmed	CAMSAP1 breaks the homeostatic microtubule network to instruct neuronal polarity.	CAMSAP3 CUX1	1.60e-04	12	55	2	32839317
Pubmed	The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.	WASHC2C WASHC2A	1.60e-04	12	55	2	19922875
Pubmed	Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women.	ESR1 PTGS2	1.60e-04	12	55	2	16453284
Pubmed	Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour.	WASHC2C WASHC2A	1.60e-04	12	55	2	27390154
Pubmed	Conservation and reorganization of loci on the mammalian X chromosome: a molecular framework for the identification of homologous subchromosomal regions in man and mouse.	PHKA2 DMD	1.60e-04	12	55	2	2899541
Pubmed	Cis-regulatory control of corticospinal system development and evolution.	PRKCG CUX1	1.89e-04	13	55	2	22678282
Pubmed	Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of VGF.	RORA CUX1	1.89e-04	13	55	2	35289744
Cytoband	18q12.1	DSC1 DSC2 DSC3	4.15e-06	26	55	3	18q12.1
Cytoband	Ensembl 112 genes in cytogenetic band chr10q11	ARHGAP22 SYT15B WASHC2C WASHC2A	7.89e-05	188	55	4	chr10q11
Cytoband	Ensembl 112 genes in cytogenetic band chr18q12	DSC1 DSC2 DSC3	2.72e-04	104	55	3	chr18q12
GeneFamily	Desmosomal cadherins	DSC1 DSC2 DSC3	2.31e-07	7	35	3	1188
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGAP22 ARHGAP24 ABR SH2B3 PLEKHA6	4.50e-05	206	35	5	682
GeneFamily	WASH complex	WASHC2C WASHC2A	5.43e-05	6	35	2	1331
GeneFamily	Nuclear hormone receptors	ESR1 RORA	4.04e-03	49	35	2	71
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP22 ARHGAP24	4.21e-03	50	35	2	721
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_emap-30875_k-means-cluster#5_top-relative-expression-ranked_1000	NFE2L3 IKZF3 DMD PTGS2 BDNF	6.08e-06	102	54	5	gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_1000_k5
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#5_top-relative-expression-ranked_500	NFE2L3 RELCH ARHGAP24 IDE CUX1	4.75e-05	156	54	5	gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_500_k5
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_top-relative-expression-ranked_1000	NFE2L3 RELCH DSC2 DSC3 ESR1 RORA TF CUX1 BDNF	1.26e-04	769	54	9	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000
CoexpressionAtlas	DevelopingKidney_e15.5_Cap mesenchyme_emap-27738_top-relative-expression-ranked_1000	RELCH MOXD1 IKZF3 ABR KMT5B DYNC2H1 CEP41 RORA CUX1	1.39e-04	779	54	9	gudmap_developingKidney_e15.5_Cap mesenchyme_1000
CoexpressionAtlas	DevelopingKidney_e15.5_stage III -IV renal corpusc_emap-27945_k-means-cluster#4_top-relative-expression-ranked_500	RELCH ARHGAP24 RORA CUX1	1.53e-04	106	54	4	gudmap_developingKidney_e15.5_stage III -IV renal corpusc_500_k4
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#5_top-relative-expression-ranked_1000	NFE2L3 DSC2 ESR1 RORA	1.65e-04	108	54	4	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000_k5
ToppCell	COVID-19-kidney-Fibroblast-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MOXD1 RBPMS ESR1 RORA DMD PTGS2	1.16e-07	187	55	6	76bfe8c42430a230a8bdf299575c444fb7780f24
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MOXD1 GBE1 RGS12 CUX1 BDNF	2.57e-06	176	55	5	03d194c9814e12802cd932afade69e868814cb78
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MOXD1 GBE1 RGS12 CUX1 BDNF	2.72e-06	178	55	5	a62137d7f5fac16619f8a02844cdb0be7a794bf2
ToppCell	(5)_Dendritic_cell\|World / shred on Cell_type and subtype	ARHGAP22 DSC2 SH2B3 PTGS2 RGS12	4.68e-06	199	55	5	495de74a918c5c625a2d0ef120fe4162d4ce6e76
ToppCell	Neuronal-Excitatory-eH(THEMIS)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MOXD1 GBE1 RGS12 CUX1 BDNF	4.79e-06	200	55	5	651ee624ab62720546cf71c2191996b5be3ce846
ToppCell	Transverse-(5)_Dendritic_cell-(50)_cDC2\|Transverse / shred on region, Cell_type, and subtype	ARHGAP22 DSC2 SH2B3 PTGS2 RGS12	4.79e-06	200	55	5	eea523f7512b54d7443651bce3ff6d043a9897aa
ToppCell	Neuronal-Excitatory-eH(THEMIS)-FGF10---L5-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MOXD1 GBE1 PTGS2 RGS12 CUX1	4.79e-06	200	55	5	67ba7e5703842e38fa3508ac644461489043626f
ToppCell	Neuronal-Excitatory-eH(THEMIS)-FGF10--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MOXD1 GBE1 PTGS2 RGS12 CUX1	4.79e-06	200	55	5	f545ae8486bd72159247e055f0bb2796c254af61
ToppCell	Neuronal-Excitatory-eH(THEMIS)-FGF10\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MOXD1 GBE1 PTGS2 RGS12 CUX1	4.79e-06	200	55	5	8acccefa60031541277fe6c1a7f58f7450961836
ToppCell	Transverse-Dendritic_cell-cDC2\|Transverse / Region, Cell class and subclass	ARHGAP22 DSC2 SH2B3 PTGS2 RGS12	4.79e-06	200	55	5	80730a6372627543b84d8fb1b94c481db17c6500
ToppCell	Transverse-Dendritic_cell\|Transverse / Region, Cell class and subclass	ARHGAP22 DSC2 SH2B3 PTGS2 RGS12	4.79e-06	200	55	5	b0e9eaf0e57e53645e272e2cea9f09bfcfe12a9b
ToppCell	Neuronal-Excitatory-eH(THEMIS)-FGF10-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MOXD1 GBE1 PTGS2 RGS12 CUX1	4.79e-06	200	55	5	0248fe1eac23704687a2f11c6a3775bceae7a2b1
ToppCell	Transverse-(5)_Dendritic_cell\|Transverse / shred on region, Cell_type, and subtype	ARHGAP22 DSC2 SH2B3 PTGS2 RGS12	4.79e-06	200	55	5	6c32a64f7c38818b93eec1e2d41067e5dbd90541
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_activate-7\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IKZF3 DMD WASHC2A CRAMP1	2.56e-05	138	55	4	76be06136c83c167cedece7515228ed4d29dd1f0
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6b\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NFE2L3 MOXD1 IKZF3 SVIL	2.71e-05	140	55	4	17005ca714ba03d7528fe7979ffb4654a46b666c
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NFE2L3 ARHGAP22 MOXD1 SVIL	2.78e-05	141	55	4	5ef3166c5271aa90fd0633016edfe2c74b835319
ToppCell	Mild/Remission-B_naive-1\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	WASHC2C KMT5B WASHC2A CRAMP1	2.94e-05	143	55	4	bd3f5fbd4e9e4dc414682db5607494f3ce988deb
ToppCell	Severe-B_naive-1\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	WASHC2C KMT5B WASHC2A CRAMP1	4.45e-05	159	55	4	2881b054bbeb479221ee3c38bbd9b0815b123579
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L6_THEMIS_C6orf48\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GBE1 RGS12 CUX1 BDNF	5.91e-05	171	55	4	75279ca22f5dd6cfee11c83f3a7b5f828cdec1c6
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L6_THEMIS_C6orf48\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MOXD1 GBE1 RGS12 BDNF	6.18e-05	173	55	4	8bc916ccf687df0341ec1d77d62844bf890cad47
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MOXD1 GBE1 RGS12 CUX1	6.60e-05	176	55	4	de746cdf2c777eec88cb03863e128e97ad6e8fb0
ToppCell	COVID-19_Moderate-B_intermediate\|COVID-19_Moderate / disease group, cell group and cell class	MOXD1 IKZF3 ARHGAP24 DMD	6.75e-05	177	55	4	68e3d12a0c048a2d0f1b9680c7338a35855bba30
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_THTPA\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MOXD1 GBE1 RGS12 CUX1	6.90e-05	178	55	4	e4e11e4940c911c17806200c25096928153c684d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MOXD1 RGS12 CUX1 BDNF	7.05e-05	179	55	4	820289f14ecf165758529c236bb220bb1a744f02
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MOXD1 RGS12 CUX1 BDNF	7.05e-05	179	55	4	e5f781d35449628a7f356d71e26231dd63482eec
ToppCell	BAL-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	ESYT1 CEP41 GBE1 PTGS2	7.05e-05	179	55	4	68511e87b12b8253de7771e5ccfc5869248b8450
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MOXD1 RBPMS SVIL DMD	7.05e-05	179	55	4	e860dca9b28ac5af61804bfd729cd39257cdb352
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-4_VIP_LGI2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGAP24 LRRC3B CSN1S1 RGS12	7.05e-05	179	55	4	8dd10e3a9ab39d9a770cecac6e2ed3676b79e906
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DYNC2H1 SVIL DMD BDNF	7.05e-05	179	55	4	a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MOXD1 RGS12 CUX1 BDNF	7.21e-05	180	55	4	7a9aa96fb8035020640cc7d3df0c41c730516c6f
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	SVIL GBE1 DMD BDNF	7.52e-05	182	55	4	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	COVID-19_Mild-NK_activated\|COVID-19_Mild / Disease condition and Cell class	WASHC2C KMT5B WASHC2A CRAMP1	7.68e-05	183	55	4	22bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MOXD1 DSC3 ESR1 DMD	7.85e-05	184	55	4	e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	SVIL GBE1 DMD BDNF	7.85e-05	184	55	4	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D175\|Adult / Lineage, Cell type, age group and donor	RBPMS DMD PTGS2 BDNF	8.01e-05	185	55	4	32b4e68e551d435a732f253f6ad83408c759a642
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_NK-T_mait-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	IKZF3 CEP41 RORA AFF4	8.18e-05	186	55	4	927723ad579bbd9947ff525bd501e222d3fa9289
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 RBPMS ARHGAP24 CCDC148	8.35e-05	187	55	4	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IKZF3 RORA BDNF AFF4	8.88e-05	190	55	4	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARHGAP22 DSC3 PRKCG DMD	9.25e-05	192	55	4	2f539653a20006bef814e6b4acd1023d6fdad5c6
ToppCell	droplet-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBPMS DMD BDNF SEMA4C	9.25e-05	192	55	4	a804cb101c3a5585f72217e1143584b1ca436724
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	RBPMS SVIL RORA CUX1	9.25e-05	192	55	4	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RBPMS DMD BDNF SEMA4C	9.43e-05	193	55	4	d0dcc0c11ccf99ff6b07e456d25b9742649aadd8
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	SVIL GBE1 DMD BDNF	9.43e-05	193	55	4	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	MOXD1 ESR1 SVIL PLEKHA6	9.43e-05	193	55	4	adc9fc94f9ec686a417d08c0b8b7b7ab687afec0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RORA PLEKHA6 CUX1 CCDC148	9.43e-05	193	55	4	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	COVID-19-Heart-Fib_1\|Heart / Disease (COVID-19 only), tissue and cell type	ARHGAP24 DYNC2H1 ESR1 RORA	9.82e-05	195	55	4	f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCell	10x5'v1-week_14-16-Lymphocytic_B-B_lineage-immature_B_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	MOXD1 IKZF3 PRKCG DMD	9.82e-05	195	55	4	ecaaa3d071e763c40d05d088fbf9e8ca06f78f47
ToppCell	COVID-19-kidney-Fibroblast-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MOXD1 ESR1 RORA PTGS2	9.82e-05	195	55	4	3d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP24 ESR1 DMD CUX1	1.02e-04	197	55	4	5bc11aff92da2a0aca8473f997fe7a99f3cae75d
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CPAMD8 RBPMS PLEKHA6 CCDC148	1.02e-04	197	55	4	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	severe-B_intermediate\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MOXD1 IKZF3 ARHGAP24 DMD	1.06e-04	199	55	4	17283d75a2a900369f63ed02996e7ede97f46140
ToppCell	Sigmoid-(5)_Dendritic_cell-(50)_cDC2\|Sigmoid / shred on region, Cell_type, and subtype	ARHGAP22 DSC2 PTGS2 RGS12	1.06e-04	199	55	4	402af84db90d8a49d67cf44c24766aefb00fd716
ToppCell	Sigmoid-Dendritic_cell-cDC2\|Sigmoid / Region, Cell class and subclass	ARHGAP22 DSC2 PTGS2 RGS12	1.06e-04	199	55	4	cd74db6db694b68f81dcf9d9342d125d00357ec1
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-MEC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MOXD1 DSC3 SVIL MSTN	1.08e-04	200	55	4	53160551d558148d1d80ec87b90dd6be7d36e4c7
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-MEC-MEC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MOXD1 DSC3 SVIL MSTN	1.08e-04	200	55	4	af4d922659b6f9d446797f7a3922a211e22f88e4
ToppCell	Sigmoid-Dendritic_cell\|Sigmoid / Region, Cell class and subclass	ARHGAP22 DSC2 PTGS2 RGS12	1.08e-04	200	55	4	994a49317b806d115c630cd90897a91fc85ff467
ToppCell	Skin-Keratinocytes\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	DSC1 DSC3 CAMSAP3 RORA	1.08e-04	200	55	4	59d72395199bc30df0e811fbc99149694e208860
ToppCell	Sigmoid-(5)_Dendritic_cell\|Sigmoid / shred on region, Cell_type, and subtype	ARHGAP22 DSC2 PTGS2 RGS12	1.08e-04	200	55	4	1130328863a4fcfa7dcd7261e9905943057777c5
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PHKA2 ARHGAP22 DSC2 SH2B3	1.08e-04	200	55	4	f11ae9055e72c938b6c9e52701478b2eee681ac4
ToppCell	(50)_cDC2\|World / shred on Cell_type and subtype	ARHGAP22 DSC2 PTGS2 RGS12	1.21e-04	206	55	4	d519adeb8290fcce107e81a439ba3bf1e231b55b
Drug	nigrosine	DSC1 DSC2 CSN1S1 TF	2.90e-07	24	54	4	CID005359556
Drug	Piperidino acetanilide	DSC1 DSC2 DSC3	4.38e-07	7	54	3	CID000078402
Drug	sodium iron chlorophyllin	GBE1 TF	5.52e-06	2	54	2	CID000169450
Drug	nNOS inhibitor I	DSC1 DSC2 DSC3 PTGS2	6.50e-06	51	54	4	CID000656911
Drug	Proguanil hydrochloride [637-32-1]; Up 200; 13.8uM; MCF7; HT_HG-U133A	IKZF3 ABR DSC2 DSC3 ESR1 RGS12	7.11e-06	197	54	6	5506_UP
Drug	Nicardipine hydrochloride [54527-84-3]; Down 200; 7.8uM; MCF7; HT_HG-U133A	PTPRA SH2B3 ESR1 SVIL RGS12 AFF4	7.11e-06	197	54	6	3215_DN
Drug	Waste Water	ESR1 PTGS2	1.65e-05	3	54	2	ctd:D062065
Drug	rhapontigenin	ESR1 TF	1.65e-05	3	54	2	ctd:C431126
Drug	procyanidin	PHKA2 ABR PRKCG PTGS2	2.44e-05	71	54	4	CID000107876
Drug	4,4'-dihydroxybiphenyl	ESR1 PTGS2	3.30e-05	4	54	2	ctd:C027439
Drug	penduletin	ESR1 PTGS2	3.30e-05	4	54	2	CID005320462
Drug	IX-X	DMD MSTN	3.30e-05	4	54	2	CID000067534
Drug	plakin	DSC1 DSC2 DSC3 DMD	4.31e-05	82	54	4	CID000018752
Drug	dioxetane	ABR PISD IDE	4.41e-05	29	54	3	CID000122029
Drug	Gf 109	CSN1S1 PRKCG TF	4.89e-05	30	54	3	CID000196144
Drug	diacetylcurcumin	PTGS2 BDNF	5.50e-05	5	54	2	ctd:C493686
Drug	deoxybenzoin	ABR ESR1	5.50e-05	5	54	2	CID000009948
Drug	LY294002	SH2B3 ESR1 PRKCG MSTN TF PTGS2 SLC2A11 CUX1 BDNF	6.01e-05	748	54	9	CID000003973
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	DSC2 ESR1 SVIL RGS12 SEMA4C	6.23e-05	177	54	5	3227_DN
Drug	Crotamiton [483-63-6]; Down 200; 19.6uM; MCF7; HT_HG-U133A	LARP4B RBPMS PTPRA DSC2 ESR1	6.58e-05	179	54	5	3388_DN
Drug	chromium picolinate	IDE TF SLC2A11	7.16e-05	34	54	3	CID000151932
Drug	acetate	CSN1S1 ESR1 PRKCG IDE TF PTGS2 CRAMP1 TUFM	7.84e-05	599	54	8	CID000000175
Drug	AC1Q5I2K	ABR TF	8.23e-05	6	54	2	CID000105127
Drug	Tubocurarine chloride pentahydrate (+) [6989-98-6]; Up 200; 5.2uM; MCF7; HT_HG-U133A	RBPMS DSC3 ESR1 CEP41 SLC2A11	8.72e-05	190	54	5	2887_UP
Drug	Trimethadione [127-48-0]; Up 200; 28uM; MCF7; HT_HG-U133A	DSC2 ESR1 PLEKHA6 RGS12 SEMA4C	9.16e-05	192	54	5	2846_UP
Drug	5213008; Up 200; 18uM; MCF7; HT_HG-U133A_EA	LARP4B PTPRA SH2B3 ESR1 SLC2A11	9.61e-05	194	54	5	898_UP
Drug	Beclomethasone dipropionate [5534-09-8]; Up 200; 7.6uM; HL60; HT_HG-U133A	RBPMS NDOR1 ESR1 TF BDNF	9.85e-05	195	54	5	3001_UP
Drug	Procyclidine hydrochloride [1508-76-5]; Down 200; 12.4uM; MCF7; HT_HG-U133A	PHKA2 LARP4B RBPMS DSC2 RGS12	9.85e-05	195	54	5	3330_DN
Drug	Apomorphine hydrochloride hemihydrate [41372-20-7]; Down 200; 6.4uM; MCF7; HT_HG-U133A	PTPRA DSC2 SH2B3 ESR1 SEMA4C	9.85e-05	195	54	5	1505_DN
Drug	alpha-estradiol; Up 200; 0.01uM; HL60; HT_HG-U133A	MOXD1 NDOR1 RGS12 BDNF AFF4	1.01e-04	196	54	5	2670_UP
Drug	Flavone	ESR1 GBE1 MSTN PTGS2	1.01e-04	102	54	4	CID000010680
Drug	Thiorphan [76721-89-6]; Up 200; 15.8uM; MCF7; HT_HG-U133A	PHKA2 ESR1 RGS12 SLC2A11 AFF4	1.03e-04	197	54	5	6249_UP
Drug	Methantheline bromide [53-46-3]; Down 200; 9.6uM; MCF7; HT_HG-U133A	DSC2 DYNC2H1 ESR1 SVIL PLEKHA6	1.06e-04	198	54	5	3560_DN
Drug	Homosalate [118-56-9]; Up 200; 15.2uM; MCF7; HT_HG-U133A	NDOR1 DSC2 CEP41 RORA BDNF	1.06e-04	198	54	5	3879_UP
Drug	Benzocaine [94-09-7]; Down 200; 24.2uM; MCF7; HT_HG-U133A	PTPRA DSC2 SVIL PLEKHA6 RGS12	1.06e-04	198	54	5	4808_DN
Drug	Pepstatin A [26305-03-3]; Up 200; 5.8uM; MCF7; HT_HG-U133A	PTPRA DSC3 ESR1 RGS12 SLC2A11	1.06e-04	198	54	5	4790_UP
Drug	arachidonic acid sodium salt; Up 200; 10uM; MCF7; HG-U133A	PHKA2 PTPRA DSC2 ESR1 SEMA4C	1.06e-04	198	54	5	443_UP
Drug	Norethindrone [68-22-4]; Down 200; 13.4uM; MCF7; HT_HG-U133A	LARP4B PTPRA PLEKHA6 RGS12 AFF4	1.11e-04	200	54	5	5474_DN
Drug	2-propylpentanoic acid; Up 200; 50uM; HL60; HT_HG-U133A	LARP4B ESR1 RORA PLEKHA6 SLC2A11	1.11e-04	200	54	5	6181_UP
Drug	2,2-di(4-methacryloxyphenyl)propane	ESR1 PTGS2	1.15e-04	7	54	2	ctd:C002462
Drug	protactinium	MOXD1 TF	1.15e-04	7	54	2	CID000023945
Drug	diethylamine hydrochloride	CSN1S1 ESR1	1.15e-04	7	54	2	CID000012618
Drug	Nifedipine	ESR1 DMD PTGS2 BDNF	1.45e-04	112	54	4	ctd:D009543
Drug	NSC524461	DSC1 DSC2 DSC3	1.46e-04	43	54	3	CID000352040
Drug	phenanthrene	MOXD1 ESR1 IDE PTGS2	1.50e-04	113	54	4	ctd:C031181
Drug	Tripe	DSC1 DSC2	1.53e-04	8	54	2	CID000015115
Drug	VX	PTGS2 BDNF	1.53e-04	8	54	2	ctd:C009680
Disease	arrhythmogenic right ventricular cardiomyopathy (implicated_via_orthology)	DSC1 DSC2 DSC3	4.85e-08	5	51	3	DOID:0050431 (implicated_via_orthology)
Disease	desmocollin-2 measurement	DSC1 DSC2 DSC3	4.85e-08	5	51	3	EFO_0021936
Disease	total blood protein measurement	RBPMS IKZF3 SH2B3 ESR1 RORA TF RGS12	1.17e-05	449	51	7	EFO_0004536
Disease	Schizophrenia	PTPRA ESR1 IDE PLEKHA6 TF PTGS2 RGS12 BDNF RAI1	1.82e-05	883	51	9	C0036341
Disease	Acute Confusional Senile Dementia	ESR1 IDE TF BDNF	2.64e-05	99	51	4	C0546126
Disease	Alzheimer's Disease, Focal Onset	ESR1 IDE TF BDNF	2.64e-05	99	51	4	C0750900
Disease	Alzheimer Disease, Early Onset	ESR1 IDE TF BDNF	2.64e-05	99	51	4	C0750901
Disease	Presenile dementia	ESR1 IDE TF BDNF	2.64e-05	99	51	4	C0011265
Disease	Alzheimer Disease, Late Onset	ESR1 IDE TF BDNF	2.64e-05	99	51	4	C0494463
Disease	Familial Alzheimer Disease (FAD)	ESR1 IDE TF BDNF	2.75e-05	100	51	4	C0276496
Disease	Obesity	ESR1 TF PTGS2 AFF4 RAI1	2.79e-05	205	51	5	C0028754
Disease	Alzheimer's Disease	ESR1 IDE TF BDNF	2.86e-05	101	51	4	C0002395
Disease	leiomyosarcoma	DMD PTGS2	2.92e-05	5	51	2	C0023269
Disease	Leiomyosarcoma, Epithelioid	DMD PTGS2	2.92e-05	5	51	2	C0205815
Disease	Leiomyosarcoma, Myxoid	DMD PTGS2	2.92e-05	5	51	2	C0205816
Disease	Inflammation	SH2B3 TF PTGS2 BDNF	6.99e-05	127	51	4	C0021368
Disease	cystitis (implicated_via_orthology)	PTGS2 BDNF	8.15e-05	8	51	2	DOID:1679 (implicated_via_orthology)
Disease	cognitive disorder (is_implicated_in)	DMD BDNF	1.05e-04	9	51	2	DOID:1561 (is_implicated_in)
Disease	blood urea nitrogen measurement	LARP4B RBPMS SH2B3 RORA PLEKHA6 DMD	1.26e-04	452	51	6	EFO_0004741
Disease	Alzheimer's disease (implicated_via_orthology)	IDE PTGS2 BDNF	1.33e-04	57	51	3	DOID:10652 (implicated_via_orthology)
Disease	Coronary Arteriosclerosis	SH2B3 ESR1 PTGS2	1.97e-04	65	51	3	C0010054
Disease	Coronary Artery Disease	SH2B3 ESR1 PTGS2	1.97e-04	65	51	3	C1956346
Disease	Grand Mal Status Epilepticus	DMD PTGS2 BDNF	2.16e-04	67	51	3	C0311335
Disease	Status Epilepticus, Subclinical	DMD PTGS2 BDNF	2.16e-04	67	51	3	C0751522
Disease	Simple Partial Status Epilepticus	DMD PTGS2 BDNF	2.16e-04	67	51	3	C0751524
Disease	Non-Convulsive Status Epilepticus	DMD PTGS2 BDNF	2.16e-04	67	51	3	C0751523
Disease	Petit mal status	DMD PTGS2 BDNF	2.16e-04	67	51	3	C0270823
Disease	Complex Partial Status Epilepticus	DMD PTGS2 BDNF	2.16e-04	67	51	3	C0393734
Disease	Status Epilepticus	DMD PTGS2 BDNF	2.25e-04	68	51	3	C0038220
Disease	pleurisy (implicated_via_orthology)	ESR1 PTGS2	2.26e-04	13	51	2	DOID:10247 (implicated_via_orthology)
Disease	C-X-C motif chemokine 11 measurement	SH2B3 CUX1	2.63e-04	14	51	2	EFO_0008057
Disease	diabetic neuropathy (implicated_via_orthology)	PTGS2 BDNF	2.63e-04	14	51	2	DOID:9743 (implicated_via_orthology)
Disease	birth weight, parental genotype effect measurement	SH2B3 ESR1 RORA RAI1	3.42e-04	192	51	4	EFO_0004344, EFO_0005939
Disease	Glycogen storage disease	PHKA2 GBE1	3.92e-04	17	51	2	cv:C0017919
Disease	Autism Spectrum Disorders	CEP41 BDNF RAI1	4.35e-04	85	51	3	C1510586
Disease	Malignant neoplasm of breast	DSC3 LRRC3B DYNC2H1 ESR1 DHX32 DMD PTGS2 CUX1	4.76e-04	1074	51	8	C0006142
Disease	tuberculosis	DYNC2H1 RORA DMD RGS12	5.33e-04	216	51	4	MONDO_0018076
Disease	in situ carcinoma (is_marker_for)	ESR1 PTGS2	6.02e-04	21	51	2	DOID:8719 (is_marker_for)
Disease	status epilepticus (implicated_via_orthology)	PTGS2 BDNF	6.02e-04	21	51	2	DOID:1824 (implicated_via_orthology)
Disease	Deafness	PISD BDNF	8.57e-04	25	51	2	C0011053
Disease	melanoma	DSC1 PTGS2 CUX1 RAI1	8.93e-04	248	51	4	C0025202
Disease	Mental Depression	ESR1 RORA PTGS2 BDNF	9.75e-04	254	51	4	C0011570
Disease	Glycogen Storage Disease	PHKA2 GBE1	1.00e-03	27	51	2	C0017919
Disease	Intellectual Disability	PRKCG RORA PISD BDNF RAI1	1.03e-03	447	51	5	C3714756
Disease	osteoarthritis (is_implicated_in)	ESR1 PTGS2	1.08e-03	28	51	2	DOID:8398 (is_implicated_in)
Disease	Autistic Disorder	RORA TF PTGS2 BDNF	1.08e-03	261	51	4	C0004352
Disease	muscular atrophy (biomarker_via_orthology)	DMD MSTN	1.15e-03	29	51	2	DOID:767 (biomarker_via_orthology)
Disease	Parkinsonism (implicated_via_orthology)	ESR1 PTGS2	1.15e-03	29	51	2	DOID:0080855 (implicated_via_orthology)
Disease	Marijuana Abuse	ESR1 PTGS2	1.24e-03	30	51	2	C0024809
Disease	Colorectal Carcinoma	RELCH CPAMD8 LRRC3B DMD PTGS2 CUX1	1.29e-03	702	51	6	C0009402
Disease	arteriosclerosis (is_implicated_in)	ESR1 PTGS2	1.32e-03	31	51	2	DOID:2349 (is_implicated_in)
Disease	Malignant Neoplasms	ESR1 PTGS2 CUX1	1.43e-03	128	51	3	C0006826
Disease	Cardiomyopathies	DSC2 DMD PTGS2	1.49e-03	130	51	3	C0878544
Disease	Depressive disorder	ESR1 RORA PTGS2 BDNF	1.57e-03	289	51	4	C0011581
Disease	Hereditary Diffuse Gastric Cancer	LRRC3B RORA PTGS2 BDNF	1.65e-03	293	51	4	C1708349

Protein segments in the cluster

Peptide	Gene	Start	Entry
RELPEPLLTDRLYPA	ABR	726	Q12979
PDPYVSLLLLPDKNR	ESYT1	1006	Q9BSJ8
PIELESLECPYPDLK	CCDC148	211	Q8NFR7
PLEPPLLFLLEEYKN	BDNF	101	P23560
VYKRLIDVPDPVPAL	CUX1	81	P39880
KPYPDCPFLLLDVRD	CEP41	166	Q9BYV8
LEKLYQEPRELPPEE	DMD	2881	P11532
LLEIIKRIELPYAEP	DHX32	591	Q7L7V1
PLSLEDLLYVPPPLK	CAMSAP3	286	Q9P1Y5
YTPELPLPLIIKIED	DSC2	221	Q02487
LLSPLSEPDDRYPLI	AFF4	701	Q9UHB7
LPLDPAEPEIRLKYI	RAI1	1566	Q7Z5J4
LPLDIKPRELYLLFR	RBPMS	31	Q93062
LNIPKPPDLLQLYRD	RELCH	296	Q9P260
LAVLPYELRFKEPLP	NOB1	46	Q9ULX3
EDDFIPLPPAKRLRL	KMT5B	846	Q4FZB7
LAEPAERYREPPALK	LARP4B	686	Q92615
AVALARPKLPLRYPE	CSN1S1	11	P47710
LKIPLERPLGEVYLD	ESR1	31	P03372
LRVDLDLYLLLPPPT	NFE2L3	26	Q9Y4A8
DLYLLLPPPTLLQDE	NFE2L3	31	Q9Y4A8
AVELYPALLVEKPRP	PTGS2	486	P35354
LSDPYVKLKLIPDPR	PRKCG	191	P05129
KEIPRDLPPETVLLY	LRRC3B	56	Q96PB8
YIPVPARDLEKPFLL	TUFM	246	P49411
RRLPLPKPLYLETEN	OVOS2	676	Q6IE36
AIPPDYLLDLIPVIR	NDOR1	366	Q9UHB4
LKLYLRELPEPVIPY	ARHGAP24	211	Q8N264
PGLYTLEELEPLLLP	DYNC2H1	2736	Q8NCM8
PELARLLEIDPYLKP	GBE1	26	Q04446
LPLLPESPRYLLIDC	SLC2A11	206	Q9BYW1
YSADLPLPLPIRVED	DSC3	221	Q14574
LPKFELLIDPPRYIQ	CPAMD8	226	Q8IZJ3
LEDELSLLDPLPRYL	CRAMP1	551	Q96RY5
APEYPLPLIIKIEDD	DSC1	221	Q08554
EILPLEKEATPYPAL	IDE	536	P14735
PLLKEVPRSYELLKP	IKZF3	416	Q9UKT9
APLPPEELTKLIYEA	PHKA2	866	P46019
RKYPPLPVDKLEEEI	PTPRA	216	P18433
DYRDLLPGILPLPKL	SSPOP	2166	A2VEC9
PLPEGVDPLKLEIYL	SVIL	2166	O95425
LPKAPPLRELIDQYD	MSTN	81	O14793
TERTLVYPLELPKEP	SEMA4C	701	Q9C0C4
LKLYLRELPEPVVPF	ARHGAP22	231	Q7Z5H3
PDKVLIPERYIDLEP	PLEKHA6	921	Q9Y2H5
IGLLYCDLPEPRKPL	TF	151	P02787
KEDLVLPEFLRLPPG	RGS12	1211	O14924
LPPDIERPYKAEPLV	MOXD1	566	Q6UVY6
PDIVRLHFPPLYKEL	RORA	496	P35398
YRERELEKLGLEIPP	PISD	86	Q9UG56
PLVKLYLLPDERRFL	SYT15B	236	X6R8R1
PPPEALKEAVLRYSL	SH2B3	191	Q9UQQ2
LILEPKDLYIDRPLP	WASHC2C	171	Q9Y4E1
QLELPPLYERARKPE	nan	136	Q3C1V9
LILEPKDLYIDRPLP	WASHC2A	171	Q641Q2
LPLVEVKPPQLIDYL	TARBP1	1516	Q13395
DRLILELKLPPTDAY	EFTUD2	261	Q15029