Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

AGGF1 FOXN1 SMARCA5 MAP7D1 KMT2D ABI1 PELP1

1.76e-0685725725609649
Pubmed

Inducing mutations in the mouse genome with the chemical mutagen ethylnitrosourea.

FOXN1 KMT2D

2.97e-06425216972005
Pubmed

KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition.

FOXN1 KMT2D

2.97e-06425236525973
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SHANK1 ZNF462 MAP7D1 ABI1 BSN PELP1 PRR36

3.79e-0696325728671696
Pubmed

IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ.

SHANK1 BSN

4.95e-06525221940441
Pubmed

Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea.

SHANK1 BSN

1.39e-05825223217150
Pubmed

Superresolution imaging of chemical synapses in the brain.

SHANK1 BSN

1.78e-05925221144999
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

PCARE SMARCA5 KMT2D PELP1

2.26e-0523425436243803
Pubmed

The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.

SMARCA5 KMT2D

3.85e-051325216510874
Pubmed

The SCF-FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage.

KMT2D PRR36

3.85e-051325236395886
Pubmed

Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.

SHANK1 ABI1

4.49e-051425221795692
Pubmed

Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.

SMARCA5 KMT2D

5.18e-051525216510875
Pubmed

The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.

SHANK1 ABI1

1.99e-042925219208628
Pubmed

Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome.

SMARCA5 RARG

2.28e-043125215778864
Pubmed

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

KMT2D PELP1

2.28e-043125215960975
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

ZNF462 SMARCA5 KMT2D

2.31e-0416725320362541
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

SMARCA5 MAP7D1 MAP1S MMP19

4.11e-0449725436774506
Pubmed

Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.

SMARCA5 PELP1

4.20e-044225235705031
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

SHANK1 MAP7D1 ABI1 BSN MAP1S PRR36

4.33e-04143125637142655
Pubmed

Impact of WIN site inhibitor on the WDR5 interactome.

ZNF462 KMT2D

4.40e-044325233472061
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

ZNF462 SMARCA5 KMT2D

5.18e-0422025335785414
Pubmed

Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome.

ROBO3 GNB1L

5.26e-044725224357327
Pubmed

Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS.

SMARCA5 MAP7D1 PELP1

5.75e-0422825330471916
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

MAP7D1 BSN DYRK1B

6.12e-0423325337704626
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

SMARCA5 ABI1 MAP1S PELP1

6.43e-0456025435241646
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

SHANK1 SYT5 ABI1 MEGF8

6.43e-0456025421653829
Pubmed

Proteomic analysis of in vivo phosphorylated synaptic proteins.

BSN DYRK1B

6.68e-045325215572359
CytobandEnsembl 112 genes in cytogenetic band chr12q13

TNS2 KMT2D RARG MMP19

7.71e-05423254chr12q13
CytobandEnsembl 112 genes in cytogenetic band chr19q13

SHANK1 SYT5 ZNF526 MEGF8 DYRK1B

4.03e-041192255chr19q13
Cytoband19q13.2

ZNF526 DYRK1B

3.61e-0316425219q13.2
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FOXN1 SYT5 BSN PRR36

2.34e-0617025402f0be0aab8ba2d35a83238609352ef3677511c9
DrugSimvastatin [79902-63-9]; Up 200; 9.6uM; HL60; HT_HG-U133A

KMT2D ROBO3 MMP19 GNB1L

4.87e-051872543002_UP
Drug5213008; Down 200; 18uM; MCF7; HT_HG-U133A_EA

TNS2 MAP1S PRR36 GNB1L

5.73e-05195254898_DN
DrugCefotaxime sodium salt [64485-93-4]; Down 200; 8.4uM; PC3; HT_HG-U133A

AGGF1 TNS2 ROBO3 MAP1S

5.85e-051962545830_DN
DrugPrednisolone [50-24-8]; Up 200; 11uM; MCF7; HT_HG-U133A

TNS2 SYT5 ROBO3 PRR36

6.20e-051992545526_UP
DrugTerazosin hydrochloride [63590-64-7]; Up 200; 9.4uM; MCF7; HT_HG-U133A

SHANK1 SYT5 MEGF8 DYRK1B

6.20e-051992546092_UP
DrugEpirizole [18694-40-1]; Down 200; 17uM; MCF7; HT_HG-U133A

MAP7D1 RARG MAP1S PRR36

6.32e-052002541681_DN
DiseaseHeart Diseases

RARG BSN

6.97e-0446252C0018799
DiseaseNonorganic psychosis

SHANK1 GNB1L

1.56e-0369252C0349204
DiseasePsychotic Disorders

SHANK1 GNB1L

3.31e-03101252C0033975
DiseaseIntellectual Disability

ZNF462 ZNF526 ZDHHC9

6.20e-03447253C3714756
Diseasemacula measurement

ROBO3 DYRK1B

1.11e-02189252EFO_0008375

Protein segments in the cluster

PeptideGeneStartEntry
PPPPPPDDIPMFDDS

ABI1

396

Q8IZP0
PDDIPMFDDSPPPPP

ABI1

401

Q8IZP0
MASEAPSPPRSPPPP

AGGF1

1

Q8N302
CPPEPMEPASPAPTP

ARMC5

481

Q96C12
RPPSPTSPPPPELMD

DYRK1B

551

Q9Y463
EEMVPSSPSPPPPPR

RARG

71

P13631
MTAPCPPPPPDPQFV

GNB1L

1

Q9BYB4
PPPLPDPSSICMVDP

MAP1S

831

Q66K74
AEPMPKPPPETTPTP

BSN

616

Q9UPA5
PPVPTEPSPMPDPCS

MMP19

276

Q99542
PMPVESSPPLPCPTP

MEGF8

2046

Q7Z7M0
PPLQPMGPTCPTPAP

PELP1

636

Q8IZL8
MGPTCPTPAPVPPPE

PELP1

641

Q8IZL8
PPPPMSALVPDTPPD

MAP7D1

36

Q3KQU3
SPPAPAPPVTPSKPM

MAP7D1

576

Q3KQU3
SPPFSIPSPSPPMSP

PCARE

1081

A6NGG8
MFPEPPTPGPPSPDT

SYT5

1

O00445
PTSSSMPPPQPPPHC

FOXN1

566

O15353
SPPASPPMSPSATPP

PRR36

931

Q9H6K5
PSPPASPPMSPSATP

PRR36

961

Q9H6K5
APAMSPVPPSPSPVP

SHANK1

1201

Q9Y566
MEASSEEPPPPPPLP

TMEM210

131

A6NLX4
SSTPEEMPPPEPPEP

ZDHHC9

341

Q9Y397
LTPSPPDPPQPPTDM

ROBO3

1156

Q96MS0
ETTAPPPAPAPMPDP

ZNF462

191

Q96JM2
PAPPPPPEPQQTIMC

ZNF526

611

Q8TF50
MSSAAEPPPPPPPES

SMARCA5

1

O60264
APSPEPPPPPMLSVS

TNS2

496

Q63HR2
RLSPPPEESPMSPPP

KMT2D

571

O14686
MSPPPEESPMSPPPE

KMT2D

581

O14686
LSPPPEDSPMSPPPE

KMT2D

626

O14686
SPPPEESPMSPPPEV

KMT2D

636

O14686
TDPEPVPPMILPPSP

KMT2D

991

O14686