Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionSUMO transferase activity

RGPD4 RGPD2 RANBP2 RGPD1 UBE2I RGPD3

3.32e-08361066GO:0019789
GeneOntologyMolecularFunctionSUMO ligase activity

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.58e-08201065GO:0061665
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

RGPD4 RGPD2 RANBP2 RGPD1 PPID RGPD3

2.55e-07501066GO:0003755
GeneOntologyMolecularFunctioncis-trans isomerase activity

RGPD4 RGPD2 RANBP2 RGPD1 PPID RGPD3

3.64e-07531066GO:0016859
GeneOntologyMolecularFunctionisomerase activity

RGPD4 RGPD2 RANBP2 RGPD1 RECQL PPID RGPD3

7.44e-051921067GO:0016853
GeneOntologyMolecularFunctionphosphopyruvate hydratase activity

ENO1 ENO2

1.66e-0441062GO:0004634
GeneOntologyMolecularFunctionsignaling adaptor activity

SPAG9 NLRP3 MAPK8IP3 IFNAR1 IRS2

6.26e-041291065GO:0035591
GeneOntologyMolecularFunctionGTPase binding

RGPD4 RGPD2 RANBP2 FGD2 RGPD1 RGPD3 DEPDC5 ENO1

6.71e-043601068GO:0051020
GeneOntologyMolecularFunctionphosphatidylinositol-4-phosphate binding

NLRP3 OSBP PLEKHA8

9.14e-04361063GO:0070273
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

3.85e-1091055GO:0033133
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

7.67e-10101055GO:1903301
GeneOntologyBiologicalProcessregulation of glucokinase activity

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

3.87e-09131055GO:0033131
GeneOntologyBiologicalProcessregulation of hexokinase activity

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.99e-09141055GO:1903299
GeneOntologyBiologicalProcessprotein peptidyl-prolyl isomerization

RGPD4 RGPD2 RANBP2 RGPD1 PPID RGPD3

3.64e-08381056GO:0000413
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

4.53e-08201055GO:0006607
GeneOntologyBiologicalProcesscarbohydrate biosynthetic process

RGPD4 GPD1 RGPD2 RANBP2 RGPD1 CHST9 RGPD3 IRS2 HAS2 ENO1 ENO2

5.38e-0824710511GO:0016051
GeneOntologyBiologicalProcessgluconeogenesis

RGPD4 GPD1 RGPD2 RANBP2 RGPD1 RGPD3 ENO1 ENO2

9.86e-081111058GO:0006094
GeneOntologyBiologicalProcesshexose biosynthetic process

RGPD4 GPD1 RGPD2 RANBP2 RGPD1 RGPD3 ENO1 ENO2

1.30e-071151058GO:0019319
GeneOntologyBiologicalProcessmonosaccharide biosynthetic process

RGPD4 GPD1 RGPD2 RANBP2 RGPD1 RGPD3 ENO1 ENO2

1.93e-071211058GO:0046364
GeneOntologyBiologicalProcesspeptidyl-proline modification

RGPD4 RGPD2 RANBP2 RGPD1 PPID RGPD3

3.19e-07541056GO:0018208
GeneOntologyBiologicalProcessmonosaccharide metabolic process

RGPD4 GPD1 RGPD2 RANBP2 CLSTN3 RGPD1 RGPD3 IRS2 POFUT1 ENO1 ENO2

5.26e-0731010511GO:0005996
GeneOntologyBiologicalProcesscarbohydrate metabolic process

RGPD4 GPD1 RGPD2 RANBP2 CLSTN3 RGPD1 CHST9 IDH1 NEU1 RGPD3 IRS2 POFUT1 HAS2 ENO1 ENO2

9.55e-0764610515GO:0005975
GeneOntologyBiologicalProcesshexose metabolic process

RGPD4 GPD1 RGPD2 RANBP2 RGPD1 RGPD3 IRS2 POFUT1 ENO1 ENO2

1.91e-0628410510GO:0019318
GeneOntologyBiologicalProcessprotein maturation

RGPD4 RGPD2 RANBP2 NLRP7 PRSS12 IFT172 RGPD1 PPID F9 NLRC4 NLRP3 RGPD3 TMPRSS2 ENO1

3.08e-0661910514GO:0051604
GeneOntologyBiologicalProcessglucose metabolic process

RGPD4 GPD1 RGPD2 RANBP2 RGPD1 RGPD3 IRS2 ENO1 ENO2

4.39e-062441059GO:0006006
GeneOntologyBiologicalProcessregulation of carbohydrate biosynthetic process

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3 IRS2 HAS2

5.07e-061321057GO:0043255
GeneOntologyBiologicalProcessmeiotic cell cycle checkpoint signaling

HUS1 NSUN2 TTK

2.05e-05111053GO:0033313
GeneOntologyBiologicalProcessregulation of carbohydrate metabolic process

RGPD4 GPD1 RGPD2 RANBP2 RGPD1 RGPD3 IRS2 HAS2

2.40e-052311058GO:0006109
GeneOntologyBiologicalProcessregulation of gluconeogenesis

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

3.10e-05711055GO:0006111
GeneOntologyBiologicalProcessnuclear export

RGPD4 RGPD2 RANBP2 RGPD1 NSUN2 UBE2I RGPD3

4.53e-051851057GO:0051168
GeneOntologyBiologicalProcessregulation of glucose metabolic process

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3 IRS2

6.39e-051341056GO:0010906
GeneOntologyBiologicalProcessmRNA transport

RGPD4 RGPD2 RANBP2 RGPD1 NSUN2 RGPD3

9.89e-051451056GO:0051028
GeneOntologyBiologicalProcessceramide transport

ABCA13 OSBP PLEKHA8

9.89e-05181053GO:0035627
GeneOntologyBiologicalProcesspositive regulation of transferase activity

RGPD4 RGPD2 RANBP2 RELN FGD2 RGPD1 MAPK8IP3 C1GALT1C1 UBE2I RGPD3

2.01e-0449010510GO:0051347
GeneOntologyBiologicalProcessventral spinal cord development

RELN FOXN4 IFT172 SCYL3

2.04e-04571054GO:0021517
GeneOntologyBiologicalProcessRNA transport

RGPD4 RGPD2 RANBP2 RGPD1 NSUN2 RGPD3

2.75e-041751056GO:0050658
GeneOntologyBiologicalProcessnucleic acid transport

RGPD4 RGPD2 RANBP2 RGPD1 NSUN2 RGPD3

2.75e-041751056GO:0050657
GeneOntologyBiologicalProcessregulation of phosphate metabolic process

RGPD4 GPD1 RGPD2 RANBP2 RELN FGD2 HUS1 RGPD1 REG3G SPAG9 IDH1 MAPK8IP3 IFNAR1 OSBP RGPD3 NLRC5 IRS2 ENO1

2.81e-04142110518GO:0019220
GeneOntologyBiologicalProcessregulation of phosphorus metabolic process

RGPD4 GPD1 RGPD2 RANBP2 RELN FGD2 HUS1 RGPD1 REG3G SPAG9 IDH1 MAPK8IP3 IFNAR1 OSBP RGPD3 NLRC5 IRS2 ENO1

2.86e-04142310518GO:0051174
GeneOntologyBiologicalProcessestablishment of RNA localization

RGPD4 RGPD2 RANBP2 RGPD1 NSUN2 RGPD3

3.01e-041781056GO:0051236
GeneOntologyBiologicalProcesszymogen activation

PRSS12 F9 NLRC4 ENO1

3.38e-04651054GO:0031638
GeneOntologyBiologicalProcesspositive regulation of protein secretion

SEC24A PPID OSBP ANKRD1 PRKCB IRS2

4.77e-041941056GO:0050714
GeneOntologyBiologicalProcessfusion of sperm to egg plasma membrane involved in single fertilization

GLIPR1L1 ADAM2 SPPL2C

6.26e-04331053GO:0007342
GeneOntologyBiologicalProcessprotein processing

NLRP7 PRSS12 IFT172 F9 NLRC4 TMPRSS2 ENO1

6.42e-042851057GO:0016485
GeneOntologyBiologicalProcesssmall molecule biosynthetic process

RGPD4 GPD1 RGPD2 RANBP2 ACSM1 RGPD1 NLRC4 OSBP RGPD3 ENO1 ENO2

6.59e-0467610511GO:0044283
GeneOntologyBiologicalProcessregulation of transferase activity

RGPD4 RGPD2 RANBP2 RELN FGD2 RGPD1 MAPK8IP3 C1GALT1C1 UBE2I RGPD3 NLRC5 IRS2

8.51e-0481010512GO:0051338
GeneOntologyBiologicalProcessRNA localization

RGPD4 RGPD2 RANBP2 RGPD1 NSUN2 RGPD3

8.57e-042171056GO:0006403
GeneOntologyBiologicalProcessplasma membrane fusion

GLIPR1L1 ADAM2 SPPL2C

8.78e-04371053GO:0045026
GeneOntologyBiologicalProcessmotor learning

CLSTN3 C1QL1

9.03e-0491052GO:0061743
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

1.77e-1081075GO:1990723
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

7.90e-10101075GO:0044614
GeneOntologyCellularComponentSUMO ligase complex

RGPD4 RGPD2 RANBP2 RGPD1 UBE2I RGPD3

7.96e-10211076GO:0106068
GeneOntologyCellularComponentannulate lamellae

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

6.17e-09141075GO:0005642
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

2.60e-08181075GO:0044615
GeneOntologyCellularComponentnuclear inclusion body

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

4.66e-08201075GO:0042405
GeneOntologyCellularComponentnuclear pore

RGPD4 RGPD2 RANBP2 RGPD1 UBE2I RGPD3

1.33e-051011076GO:0005643
GeneOntologyCellularComponentGolgi membrane

CLSTN3 SCYL3 CHST9 CREB3L1 NLRP3 MAPK8IP3 C1GALT1C1 OSBP ABCA5 COG1 HAS2 PLEKHA8 PROS1 DOP1B

1.86e-0572110714GO:0000139
GeneOntologyCellularComponentinclusion body

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

9.95e-05901075GO:0016234
GeneOntologyCellularComponentphosphopyruvate hydratase complex

ENO1 ENO2

1.55e-0441072GO:0000015
MousePhenoelevated level of mitotic sister chromatid exchange

RGPD4 RGPD2 RANBP2 RGPD1 RECQL RGPD3

3.22e-1016856MP:0003701
MousePhenoabnormal blastocyst formation

RGPD4 RGPD2 RANBP2 NLRP7 RGPD1 RGPD3

1.17e-0739856MP:0012128
MousePhenoabnormal morula morphology

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

4.39e-0726855MP:0012058
MousePhenodecreased tumor latency

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

9.33e-0730855MP:0010308
MousePhenofailure of blastocyst formation

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

1.11e-0631855MP:0012129
MousePhenoabnormal tumor latency

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

1.79e-0634855MP:0010307
MousePhenoaneuploidy

RGPD4 RGPD2 RANBP2 RGPD1 RECQL RGPD3

1.80e-0661856MP:0004024
MousePhenoenlarged epididymis

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3 TMPRSS2 PLEKHA8

2.27e-0699857MP:0004931
MousePhenoabnormal rod electrophysiology

RGPD4 RGPD2 RANBP2 RELN RGPD1 RGPD3 ROM1

7.74e-06119857MP:0004021
MousePhenoabnormal preimplantation embryo morphology

RGPD4 RGPD2 RANBP2 RGPD1 TTK OSBP PBRM1 UBE2I COG1 RGPD3

8.10e-062838510MP:0014137
MousePhenoabnormal chromosome morphology

RGPD4 RGPD2 RANBP2 HUS1 RGPD1 RECQL RGPD3

1.13e-05126857MP:0003702
MousePhenoabnormal chromosome number

RGPD4 RGPD2 RANBP2 RGPD1 RECQL RGPD3

1.35e-0586856MP:0004023
MousePhenoincreased energy expenditure

RGPD4 RGPD2 RANBP2 CLSTN3 RGPD1 NSUN2 RGPD3 TAFA1

2.48e-05196858MP:0004889
MousePhenoabnormal energy homeostasis

RGPD4 RGPD2 RANBP2 CLSTN3 RGPD1 NSUN2 NLRP3 RGPD3 TAFA1 IRS2

2.48e-053228510MP:0005448
MousePhenoincreased hepatocellular carcinoma incidence

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

6.55e-0570855MP:0003331
MousePhenoabnormal epididymis size

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3 TMPRSS2 PLEKHA8

6.65e-05166857MP:0004926
MousePhenoincreased lung carcinoma incidence

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

1.10e-0478855MP:0008714
MousePhenoabnormal energy expenditure

RGPD4 RGPD2 RANBP2 CLSTN3 RGPD1 NSUN2 NLRP3 RGPD3 TAFA1

1.17e-04313859MP:0005450
MousePhenoabnormal mitosis

RGPD4 RGPD2 RANBP2 RGPD1 RECQL RGPD3

1.27e-04128856MP:0004046
MousePhenoabnormal cell nucleus morphology

RGPD4 RGPD2 RANBP2 HUS1 RGPD1 RECQL RGPD3

1.27e-04184857MP:0003111
MousePhenoincreased incidence of tumors by chemical induction

RGPD4 RGPD2 RANBP2 RGPD1 IFNAR1 RGPD3

2.15e-04141856MP:0004499
MousePhenoincreased sarcoma incidence

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

3.87e-04102855MP:0002032
MousePhenodecreased susceptibility to diet-induced obesity

RGPD4 RGPD2 RANBP2 CLSTN3 RGPD1 RGPD3

4.25e-04160856MP:0005659
MousePhenoabnormal eye electrophysiology

RGPD4 RGPD2 RANBP2 RELN RGPD1 RGPD3 ROM1

4.70e-04228857MP:0005551
MousePhenoincreased respiratory system tumor incidence

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

4.83e-04107855MP:0010298
MousePhenoincreased lung tumor incidence

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

4.83e-04107855MP:0008014
MousePhenofailure of blastocyst to hatch from the zona pellucida

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

4.83e-04107855MP:0003694
MousePhenoincreased hepatobiliary system tumor incidence

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.71e-04111855MP:0010297
MousePhenoincreased liver tumor incidence

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.71e-04111855MP:0008019
MousePhenoabnormal preimplantation embryo development

RGPD4 RGPD2 RANBP2 NLRP7 RGPD1 RGPD3

6.04e-04171856MP:0009781
MousePhenoabnormal blastocyst hatching

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

6.19e-04113855MP:0003693
MousePhenoincreased incidence of induced tumors

RGPD4 RGPD2 RANBP2 RGPD1 IFNAR1 RGPD3

6.42e-04173856MP:0002021
DomainRan_BP1

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

4.31e-09121075PF00638
DomainRANBD1

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

4.31e-09121075PS50196
DomainRanBD

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

6.97e-09131075SM00160
DomainRan_bind_dom

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

6.97e-09131075IPR000156
DomainRab_bind

RGPD4 RGPD2 RGPD1 RGPD3

3.52e-0871074PF16704
DomainGCC2_Rab_bind

RGPD4 RGPD2 RGPD1 RGPD3

3.52e-0871074IPR032023
Domain-

RGPD4 RGPD2 RGPD1 RGPD3

2.08e-071010741.10.220.60
DomainGrip

RGPD4 RGPD2 RGPD1 RGPD3

3.26e-07111074SM00755
DomainGRIP

RGPD4 RGPD2 RGPD1 RGPD3

3.26e-07111074PF01465
DomainGRIP_dom

RGPD4 RGPD2 RGPD1 RGPD3

4.86e-07121074IPR000237
DomainGRIP

RGPD4 RGPD2 RGPD1 RGPD3

4.86e-07121074PS50913
DomainNACHT

NLRP7 NLRC4 NLRP3 NLRC5

8.29e-06231074PS50837
DomainNACHT_NTPase

NLRP7 NLRC4 NLRP3 NLRC5

8.29e-06231074IPR007111
DomainJIP_LZII

SPAG9 MAPK8IP3

3.25e-0521072IPR032486
DomainJIP_LZII

SPAG9 MAPK8IP3

3.25e-0521072PF16471
DomainCl_channel-K

CLCNKA CLCNKB

3.25e-0521072IPR002250
DomainTPR_REGION

RGPD4 RGPD2 RANBP2 IFT172 RGPD1 PPID RGPD3

4.60e-051651077PS50293
DomainTPR

RGPD4 RGPD2 RANBP2 IFT172 RGPD1 PPID RGPD3

4.60e-051651077PS50005
DomainTPR-like_helical_dom

RGPD4 RGPD2 RANBP2 IFT172 RGPD1 TTK PPID RGPD3

5.87e-052331078IPR011990
Domain-

RGPD4 RGPD2 RANBP2 FGD2 RGPD1 OSBP RGPD3 IRS2 PLEKHM3 PLEKHA8

8.33e-05391107102.30.29.30
DomainAgo_hook

TNRC6B TNRC6C

9.72e-0531072PF10427
DomainEnolase_N

ENO1 ENO2

9.72e-0531072PF03952
DomainEnolase

ENO1 ENO2

9.72e-0531072IPR000941
DomainEnolase_C

ENO1 ENO2

9.72e-0531072IPR020810
DomainEnolase_N

ENO1 ENO2

9.72e-0531072IPR020811
DomainEnolase_CS

ENO1 ENO2

9.72e-0531072IPR020809
DomainEnolase_C

ENO1 ENO2

9.72e-0531072PF00113
DomainTNRC6_PABC-bd

TNRC6B TNRC6C

9.72e-0531072IPR032226
DomainArgonaute_hook_dom

TNRC6B TNRC6C

9.72e-0531072IPR019486
DomainEnolase_N

ENO1 ENO2

9.72e-0531072SM01193
DomainTNRC6-PABC_bdg

TNRC6B TNRC6C

9.72e-0531072PF16608
DomainEnolase_C

ENO1 ENO2

9.72e-0531072SM01192
DomainENOLASE

ENO1 ENO2

9.72e-0531072PS00164
DomainTPR

RGPD4 RGPD2 RANBP2 RGPD1 PPID RGPD3

9.87e-051291076SM00028
DomainTPR_repeat

RGPD4 RGPD2 RANBP2 RGPD1 PPID RGPD3

1.17e-041331076IPR019734
Domain-

IFT172 EML6 WDR55 SPAG9 MAPK8IP3 SEMA4C CSTF1 WDR12 HERC1

1.27e-0433310792.130.10.10
DomainWD40/YVTN_repeat-like_dom

IFT172 EML6 WDR55 SPAG9 MAPK8IP3 SEMA4C CSTF1 WDR12 HERC1

1.32e-043351079IPR015943
DomainPH_dom-like

RGPD4 RGPD2 RANBP2 FGD2 RGPD1 OSBP RGPD3 IRS2 PLEKHM3 PLEKHA8

1.68e-0442610710IPR011993
Domain-

RGPD4 RGPD2 RANBP2 RGPD1 TTK PPID RGPD3

1.90e-0420710771.25.40.10
Domain-

ENO1 ENO2

1.94e-04410723.30.390.10
DomainJNK/Rab-associated_protein-1_N

SPAG9 MAPK8IP3

1.94e-0441072IPR019143
Domain-

ENO1 ENO2

1.94e-04410723.20.20.120
DomainJnk-SapK_ap_N

SPAG9 MAPK8IP3

1.94e-0441072PF09744
DomainEnolase_C-like

ENO1 ENO2

1.94e-0441072IPR029065
DomainEnolase_N-like

ENO1 ENO2

1.94e-0441072IPR029017
DomainTPR-contain_dom

RGPD4 RGPD2 RANBP2 RGPD1 PPID RGPD3

2.25e-041501076IPR013026
DomainSRCR

PRSS12 SCARA5 TMPRSS2

2.26e-04211073PF00530
DomainWD40_repeat_dom

IFT172 EML6 WDR55 SPAG9 MAPK8IP3 CSTF1 WDR12 HERC1

3.11e-042971078IPR017986
DomainRH2

SPAG9 MAPK8IP3

3.22e-0451072PS51777
DomainRH1

SPAG9 MAPK8IP3

3.22e-0451072PS51776
Domain-

RELN NEU1

3.22e-04510722.120.10.10
Domain-

PRSS12 SCARA5 TMPRSS2

3.84e-042510733.10.250.10
DomainSR

PRSS12 SCARA5 TMPRSS2

3.84e-04251073SM00202
DomainSRCR-like_dom

PRSS12 SCARA5 TMPRSS2

4.32e-04261073IPR017448
DomainSRCR_1

PRSS12 SCARA5 TMPRSS2

4.32e-04261073PS00420
DomainSRCR_2

PRSS12 SCARA5 TMPRSS2

4.32e-04261073PS50287
DomainSRCR

PRSS12 SCARA5 TMPRSS2

4.84e-04271073IPR001190
DomainCl-channel_core

CLCNKA CLCNKB

1.14e-0391072IPR014743
Domain-

CLCNKA CLCNKB

1.14e-03910721.10.3080.10
DomainVoltage_CLC

CLCNKA CLCNKB

1.14e-0391072PF00654
DomainCl-channel_volt-gated

CLCNKA CLCNKB

1.14e-0391072IPR001807
DomainSialidases

RELN NEU1

1.14e-0391072IPR011040
DomainABC_A

ABCA13 ABCA5

2.07e-03121072IPR026082
DomainCoagulation_fac_subgr_Gla_dom

F9 PROS1

2.07e-03121072IPR017857
Domain-

F9 PROS1

2.07e-031210724.10.740.10
DomainWD40_repeat_CS

EML6 WDR55 CSTF1 WDR12 HERC1

2.54e-031641075IPR019775
DomainGLA_1

F9 PROS1

2.83e-03141072PS00011
DomainGLA_2

F9 PROS1

2.83e-03141072PS50998
DomainGla

F9 PROS1

2.83e-03141072PF00594
DomainGLA

F9 PROS1

2.83e-03141072SM00069
DomainGLA_domain

F9 PROS1

2.83e-03141072IPR000294
DomainTRYPSIN_SER

OVCH2 PRSS12 F9 TMPRSS2

3.23e-031061074PS00135
DomainTRYPSIN_HIS

OVCH2 PRSS12 F9 TMPRSS2

3.34e-031071074PS00134
DomainCBS

CLCNKA CLCNKB

3.70e-03161072SM00116
DomainWD40

IFT172 EML6 WDR55 CSTF1 WDR12 HERC1

3.78e-032591076PF00400
DomainPeptidase_S1A

OVCH2 PRSS12 F9 TMPRSS2

4.06e-031131074IPR001314
DomainTRYPSIN_DOM

OVCH2 PRSS12 F9 TMPRSS2

4.33e-031151074PS50240
DomainWD40

IFT172 EML6 WDR55 CSTF1 WDR12 HERC1

4.46e-032681076SM00320
DomainTryp_SPc

OVCH2 PRSS12 F9 TMPRSS2

4.60e-031171074SM00020
DomainWD40_repeat

IFT172 EML6 WDR55 CSTF1 WDR12 HERC1

4.79e-032721076IPR001680
DomainTrypsin_dom

OVCH2 PRSS12 F9 TMPRSS2

5.18e-031211074IPR001254
DomainTrypsin

OVCH2 PRSS12 F9 TMPRSS2

5.18e-031211074PF00089
DomainCyclophilin-type_PPIase_CS

RANBP2 PPID

5.22e-03191072IPR020892
DomainWD_REPEATS_1

IFT172 EML6 WDR55 CSTF1 WDR12 HERC1

5.32e-032781076PS00678
DomainWD_REPEATS_2

IFT172 EML6 WDR55 CSTF1 WDR12 HERC1

5.41e-032791076PS50082
DomainWD_REPEATS_REGION

IFT172 EML6 WDR55 CSTF1 WDR12 HERC1

5.41e-032791076PS50294
DomainPeptidase_S1_PA

OVCH2 PRSS12 F9 TMPRSS2

5.49e-031231074IPR009003
PathwayBIOCARTA_RANBP2_PATHWAY

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

6.41e-0818875MM1549
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

RGPD4 RGPD2 RANBP2 RGPD1 UBE2I RGPD3

2.04e-0742876MM15039
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

RGPD4 RGPD2 RANBP2 RGPD1 UBE2I RGPD3

4.07e-0747876MM14939
PathwayREACTOME_GENE_SILENCING_BY_RNA

RGPD4 RGPD2 RANBP2 RGPD1 TNRC6B RGPD3

5.25e-0749876MM14837
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

RGPD4 RGPD2 RANBP2 RGPD1 UBE2I RGPD3

6.69e-0751876MM15151
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3 PRKCB

1.06e-0655876MM14917
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

RGPD4 RGPD2 RANBP2 RGPD1 UBE2I RGPD3

1.45e-0658876MM15149
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

RGPD4 RGPD2 RANBP2 RGPD1 UBE2I RGPD3

2.86e-0665876MM15147
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

4.43e-0640875MM14945
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.02e-0641875MM15200
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

6.38e-0643875MM14609
PathwayREACTOME_GLUCOSE_METABOLISM

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3 ENO2

1.12e-0582876MM15394
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

RGPD4 RGPD2 RANBP2 RGPD1 UBE2I RGPD3

1.28e-0584876MM14929
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

1.36e-0550875MM14610
PathwayREACTOME_SNRNP_ASSEMBLY

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

2.82e-0558875MM14736
PathwayREACTOME_MITOTIC_PROPHASE

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3 PRKCB

7.26e-05114876MM15361
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

8.61e-0573875MM14948
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

1.87e-0486875MM15413
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

2.57e-0492875MM14951
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

RGPD4 RGPD2 RANBP2 RGPD1 CHST9 RGPD3 HAS2 ENO2

2.65e-04271878MM15406
PathwayREACTOME_AMPLIFICATION_OF_SIGNAL_FROM_THE_KINETOCHORES

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

3.79e-04100875MM14561
PathwayREACTOME_SUMOYLATION

RGPD4 RGPD2 RANBP2 RGPD1 UBE2I RGPD3

6.15e-04169876MM14919
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

TNRC6B TNRC6C

7.75e-047872M46421
PathwayREACTOME_MITOTIC_SPINDLE_CHECKPOINT

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

7.77e-04117875MM15387
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RGPD4 RGPD2 RANBP2 RGPD1 UBE2I RGPD3

6.49e-149108628877029
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RGPD4 RGPD2 RANBP2 RGPD1 UBE2I RGPD3

1.62e-1310108627160050
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RGPD4 RGPD2 RANBP2 RGPD1 UBE2I RGPD3

3.55e-1311108634110283
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-12710859037092
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-127108511353387
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-127108530944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-127108538838144
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-12710857559465
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-127108517372272
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-127108538657106
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-127108521205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-127108518949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-127108525187515
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-12710858603673
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-127108526632511
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-127108524403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-127108523818861
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-127108523536549
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-127108512191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-127108522821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

5.49e-127108520682751
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

1.46e-118108521670213
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

1.46e-118108527412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

1.46e-118108521310149
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

1.46e-118108522262462
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

1.46e-118108528745977
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

3.28e-119108518394993
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

3.28e-119108528100513
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

3.28e-119108517887960
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

3.28e-119108511553612
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

3.28e-119108510601307
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

3.28e-11910859733766
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

6.55e-1110108516332688
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

6.55e-111010858857542
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

6.55e-1110108521859863
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

1.20e-1011108517069463
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

1.20e-1011108535771867
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

3.32e-1013108531427429
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

7.70e-1015108514697343
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD4 RGPD2 RGPD1 RGPD3

3.06e-097108415710750
Pubmed

Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

6.64e-0922108527717094
Pubmed

Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.

NLRC4 NLRP3 IFNAR1 NLRC5

8.59e-0814108426320999
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

1.22e-0738108512791264
Pubmed

IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection.

NLRC4 NLRP3 IFNAR1

5.78e-076108329321274
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

RGPD4 RGPD2 RANBP2 RGPD1 TPPP MAPK8IP3 RGPD3 PRKCB

6.67e-07231108816452087
Pubmed

Fas-mediated inflammatory response in Listeria monocytogenes infection.

NLRC4 NLRP3 IFNAR1

1.01e-067108323509366
Pubmed

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.

NLRC4 NLRP3 IFNAR1

1.01e-067108320457908
Pubmed

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila.

NLRC4 NLRP3 IFNAR1

2.41e-069108323307811
Pubmed

Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking.

NLRC4 NLRP3 IFNAR1

3.44e-0610108322474394
Pubmed

A noncanonical function of cGAMP in inflammasome priming and activation.

NLRC4 NLRP3 IFNAR1

6.28e-0612108329030458
Pubmed

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

RGPD4 RGPD2 RANBP2 RGPD1 IDH1 UBE2I RGPD3

7.13e-06226108737839992
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

7.50e-0686108537253089
Pubmed

Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells.

NLRC4 NLRP3 IFNAR1

8.14e-0613108328636595
Pubmed

Variants in NLRP3 and NLRC4 inflammasome associate with susceptibility and severity of multiple sclerosis.

NLRC4 NLRP3

9.55e-062108230658261
Pubmed

The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron.

CLCNKA CLCNKB

9.55e-062108227335120
Pubmed

Distribution of serum neuron-specific enolase and the establishment of a population reference interval in healthy adults.

ENO1 ENO2

9.55e-062108230779465
Pubmed

Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization.

CLCNKA CLCNKB

9.55e-06210828812470
Pubmed

Associations between CLCNKA_B tag SNPs with essential hypertension and interactions between genetic and environmental factors in an island population in China.

CLCNKA CLCNKB

9.55e-062108225919862
Pubmed

Inflammasome Genetic Variants, Macrophage Function, and Clinical Outcomes in Cystic Fibrosis.

NLRC4 NLRP3

9.55e-062108233848452
Pubmed

Expanding Genotype-Phenotype Correlation of CLCNKA and CLCNKB Variants Linked to Hearing Loss.

CLCNKA CLCNKB

9.55e-062108238069401
Pubmed

Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons.

SPAG9 MAPK8IP3

9.55e-062108233788575
Pubmed

The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses.

NLRC4 NLRP3

9.55e-062108230368901
Pubmed

HUPO BPP pilot study: a proteomics analysis of the mouse brain of different developmental stages.

ENO1 ENO2

9.55e-062108217922513
Pubmed

NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma.

NLRC4 NLRP3

9.55e-062108232342103
Pubmed

A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels.

CLCNKA CLCNKB

9.55e-062108220805576
Pubmed

Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion.

NLRP3 IFNAR1

9.55e-062108229317641
Pubmed

Actions of the NLRP3 and NLRC4 inflammasomes overlap in bone resorption.

NLRC4 NLRP3

9.55e-062108234383985
Pubmed

Salt wasting and deafness resulting from mutations in two chloride channels.

CLCNKA CLCNKB

9.55e-062108215044642
Pubmed

Two highly homologous members of the ClC chloride channel family in both rat and human kidney.

CLCNKA CLCNKB

9.55e-06210828041726
Pubmed

A cytoplasmic domain mutation in ClC-Kb affects long-distance communication across the membrane.

CLCNKA CLCNKB

9.55e-062108218648499
Pubmed

The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type.

RANBP2 UBE2I

9.55e-062108215378033
Pubmed

Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif.

SPAG9 MAPK8IP3

9.55e-062108231690808
Pubmed

Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney.

CLCNKA CLCNKB

9.55e-06210828544406
Pubmed

Nucleotide sequences of cDNAs alpha and gamma enolase mRNAs from mouse brain.

ENO1 ENO2

9.55e-06210822362815
Pubmed

Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases.

ENO1 ENO2

9.55e-062108222551201
Pubmed

RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function.

RBCK1 PRKCB

9.55e-062108217121852
Pubmed

Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes.

CLCNKA CLCNKB

9.55e-062108224863058
Pubmed

Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel.

CLCNKA CLCNKB

9.55e-06210829916798
Pubmed

Kidney kinetics and chloride ion pumps.

CLCNKA CLCNKB

9.55e-06210829916791
Pubmed

Complete structure of the human gene encoding neuron-specific enolase.

ENO1 ENO2

9.55e-06210822045099
Pubmed

RBCK1 Overexpression Attenuates Inflammation and Mobility of Derp1-Induced Nasal Mucosal Cells by Downregulating NLRP3.

NLRP3 RBCK1

9.55e-062108236702106
Pubmed

Rhinovirus-induced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells.

NLRP3 NLRC5

9.55e-062108223815151
Pubmed

NAIP/NLRC4 inflammasome participates in macrophage responses to Trypanosoma cruzi by a mechanism that relies on cathepsin-dependent caspase-1 cleavage.

NLRC4 NLRP3

9.55e-062108238124741
Pubmed

Isolation of murine neuron-specific and non-neuronal enolase cDNA clones.

ENO1 ENO2

9.55e-06210823801001
Pubmed

Flagellin/NLRC4 Pathway Rescues NLRP3-Inflammasome Defect in Dendritic Cells From HIV-Infected Patients: Perspective for New Adjuvant in Immunocompromised Individuals.

NLRC4 NLRP3

9.55e-062108231244842
Pubmed

Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis.

F9 PROS1

9.55e-062108229419409
Pubmed

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation.

NLRP3 RBCK1

9.55e-062108224958845
Pubmed

Passenger deletions generate therapeutic vulnerabilities in cancer.

ENO1 ENO2

9.55e-062108222895339
Pubmed

Cl(-) channels in basolateral TAL membranes XV. Molecular heterogeneity between cortical and medullary channels.

CLCNKA CLCNKB

9.55e-062108211014860
Pubmed

Noncanonical inflammasome activation by intracellular LPS independent of TLR4.

NLRC4 NLRP3 IFNAR1

1.03e-0514108323887873
Pubmed

Severe Acute Respiratory Syndrome Coronavirus 2 ORF8 Protein Inhibits Type I Interferon Production by Targeting HSP90B1 Signaling.

WDR55 VPS16 ENO1

1.03e-0514108335677655
Pubmed

Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

1.49e-0599108527746211
Pubmed

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.

NLRC4 NLRP3 IFNAR1

1.92e-0517108325774715
Pubmed

Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes.

NLRC4 NLRP3

2.86e-053108220490635
Pubmed

Human CLC-K Channels Require Palmitoylation of Their Accessory Subunit Barttin to Be Functional.

CLCNKA CLCNKB

2.86e-053108226013830
Pubmed

Barttin increases surface expression and changes current properties of ClC-K channels.

CLCNKA CLCNKB

2.86e-053108212111250
Pubmed

Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation.

NLRC4 NLRP3

2.86e-053108224798340
Pubmed

Cutting edge: nitric oxide inhibits the NLRP3 inflammasome.

NLRP3 IFNAR1

2.86e-053108223100513
Pubmed

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.

NLRC4 NLRP3

2.86e-053108221118981
Pubmed

Estrogen receptor-α, RBCK1, and protein kinase C β 1 cooperate to regulate estrogen receptor-α gene expression.

RBCK1 PRKCB

2.86e-053108223042805
InteractionRGPD2 interactions

RGPD4 RGPD2 RANBP2 RGPD1 UBE2I RGPD3

4.69e-09271056int:RGPD2
InteractionRGPD4 interactions

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

8.56e-08221055int:RGPD4
InteractionRGPD1 interactions

RGPD4 RGPD2 RANBP2 RGPD1 PBRM1 RGPD3

2.02e-07491056int:RGPD1
InteractionTRIM65 interactions

TNRC6B IDH1 NLRC4 NLRP3 RBCK1 ENO1

3.81e-06801056int:TRIM65
InteractionRGPD3 interactions

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

4.50e-06471055int:RGPD3
InteractionRGPD8 interactions

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

4.22e-05741055int:RGPD8
GeneFamilyNLR family

NLRP7 NLRC4 NLRP3 NLRC5

4.40e-0625814666
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD4 RGPD2 RANBP2 RGPD1 PPID RGPD3

1.28e-05115816769
GeneFamilySCY1 like pseudokinases

SCYL3 SCYL2

5.93e-0538121033
GeneFamilyChloride voltage-gated channels

CLCNKA CLCNKB

8.72e-0410812302
GeneFamilyWD repeat domain containing

IFT172 EML6 WDR55 CSTF1 WDR12 HERC1

1.14e-03262816362
GeneFamilyGla domain containing

F9 PROS1

1.50e-03138121250
GeneFamilyATP binding cassette subfamily A

ABCA13 ABCA5

1.74e-0314812805
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

FGD2 OSBP IRS2 PLEKHM3 PLEKHA8

2.32e-03206815682
GeneFamilyCyclophilin peptidylprolyl isomerases

RANBP2 PPID

3.23e-0319812909
GeneFamilyZinc fingers RANBP2-type |RNA binding motif containing

RANBP2 RBCK1

3.94e-032181289
GeneFamilyAtaxins|Trinucleotide repeat containing

TNRC6B TNRC6C

5.56e-0325812775
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

NLRP7 NLRP3

5.56e-0325812994
GeneFamilyCD molecules|Tetraspanins

TSPAN16 ROM1

9.57e-0333812768
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

2.24e-07331075MM477
CoexpressionTABULA_MURIS_SENIS_TRACHEA_GRANULOCYTE_AGEING

RGPD4 RGPD2 RANBP2 RGPD1 RGPD3

8.78e-07431075MM3857
CoexpressionHOUNKPE_HOUSEKEEPING_GENES

RGPD4 RGPD2 RANBP2 RGPD1 WDR55 MRPS16 SPAG9 VPS16 PPID RBCK1 HP1BP3 MAPK8IP3 SCYL2 OSBP UBE2I RGPD3 GATAD1 POFUT1

1.01e-06115810718MM1338
DiseaseBartter disease type 4B

CLCNKA CLCNKB

1.18e-0521022cv:C4310805
DiseaseBARTTER SYNDROME, TYPE 4B

CLCNKA CLCNKB

1.18e-0521022C2751312
DiseaseBARTTER SYNDROME, TYPE 4B, NEONATAL, WITH SENSORINEURAL DEAFNESS

CLCNKA CLCNKB

1.18e-0521022C4310805
DiseaseBartter disease type 3 (implicated_via_orthology)

CLCNKA CLCNKB

1.18e-0521022DOID:0110144 (implicated_via_orthology)
DiseaseBartter disease type 4b (is_implicated_in)

CLCNKA CLCNKB

1.18e-0521022DOID:0110146 (is_implicated_in)
DiseaseBARTTER SYNDROME, TYPE 4B, NEONATAL, WITH SENSORINEURAL DEAFNESS

CLCNKA CLCNKB

1.18e-0521022613090
DiseaseBartter disease (implicated_via_orthology)

CLCNKA CLCNKB

1.18e-0521022DOID:445 (implicated_via_orthology)
DiseaseAutosomal Dominant Lateral Temporal Lobe Epilepsy

RELN DEPDC5

3.54e-0531022C1838062
DiseaseChronic Infantile Neurological, Cutaneous, and Articular Syndrome

NLRC4 NLRP3

7.07e-0541022C0409818
DiseaseFamilial Cold Autoinflammatory Syndrome 1

NLRC4 NLRP3

7.07e-0541022C4551895
DiseaseCryopyrin-Associated Periodic Syndromes

NLRC4 NLRP3

7.07e-0541022C2316212
DiseaseFamilial cold urticaria

NLRC4 NLRP3

7.07e-0541022C0343068
DiseaseFamilial cold autoinflammatory syndrome

NLRC4 NLRP3

7.07e-0541022cv:C0343068
DiseaseMuckle-Wells Syndrome

NLRC4 NLRP3

1.18e-0451022C0268390
Diseaseoxytocin-neurophysin 1 measurement

NLRP3 IFNAR1

1.76e-0461022EFO_0802839
DiseaseBartter syndrome

CLCNKA CLCNKB

1.76e-0461022cv:C0004775
DiseaseHereditary Autoinflammatory Diseases

NLRC4 NLRP3

2.46e-0471022C0751422
Diseasenephrogenic diabetes insipidus (implicated_via_orthology)

CLCNKA CLCNKB

5.23e-04101022DOID:12387 (implicated_via_orthology)
Diseasealcohol and nicotine codependence

RGPD2 RGPD1

9.00e-04131022EFO_0004776
Diseasemood disorder

RELN PBRM1

9.00e-04131022EFO_0004247
DiseaseOpioid use measurement

NLRP7 MYOM2

1.21e-03151022EFO_0009937
DiseaseAnimal Mammary Neoplasms

TP53I3 UBE2I MRC2 ENO1

1.52e-031421024C0024667
DiseaseMammary Carcinoma, Animal

TP53I3 UBE2I MRC2 ENO1

1.52e-031421024C1257925
DiseaseCarcinomatosis

TP53I3 UBE2I MRC2 ENO1

2.51e-031631024C0205699
DiseaseCarcinoma, Spindle-Cell

TP53I3 UBE2I MRC2 ENO1

2.51e-031631024C0205697
DiseaseUndifferentiated carcinoma

TP53I3 UBE2I MRC2 ENO1

2.51e-031631024C0205698
DiseaseAnaplastic carcinoma

TP53I3 UBE2I MRC2 ENO1

2.51e-031631024C0205696
DiseaseCarcinoma

TP53I3 UBE2I MRC2 ENO1

2.56e-031641024C0007097
DiseaseColorectal Carcinoma

CLSTN3 ABCA13 IDH1 OSBP ABCA5 TOMM40L PRKCB PROS1

3.04e-037021028C0009402
Diseasedisease free survival, response to mepolizumab

NLRP3 IFNAR1

3.11e-03241022EFO_0000409, EFO_0008459
DiseaseIntrahepatic Cholangiocarcinoma

IDH1 PBRM1

3.11e-03241022C0345905
DiseaseExtrahepatic Cholangiocarcinoma

IDH1 PBRM1

3.11e-03241022C3805278

Protein segments in the cluster

PeptideGeneStartEntry
MVGSCDRQTKNGAKW

nan

16

Q0VG73
LKCVGSSMFLKSKWG

ABCA5

691

Q8WWZ7
AWALGHKLCSIMVKQ

CREB3L1

116

Q96BA8
PALMIGACWTEEKNK

CLSTN3

486

Q9BQT9
KMWIKDGTSCGSNKV

ADAM2

586

Q99965
KNCAGKTPMDLVLHW

ANKRD1

281

Q15327
DGTSMWADLCKNGQV

C1QL1

186

O75973
MGHAGCQFKALLWKN

ABCA13

1

Q86UQ4
GRKWMDSLLSNLGCQ

APEX2

221

Q9UBZ4
KCPEQGGMIWKISED

C1GALT1C1

206

Q96EU7
ESADNCKAMKGKNPW

CECR2

1031

Q9BXF3
ACKLAQENGWGVMVS

ENO2

356

P09104
DKMARWNVLGCQGAL

ADAT1

301

Q9BUB4
CEKNGWMEQISGKGF

HP1BP3

391

Q5SSJ5
GMFTKKEGQWDCSVC

RANBP2

1601

P49792
CQGHWKIGDTAMALL

TP53I3

76

Q53FA7
NISDNWLGGAFICKM

QRFPR

106

Q96P65
KDTSMKLWCAVGVNL

SPAG9

681

O60271
CSGDGTMRKNIDVWK

NSUN2

271

Q08J23
AGELWVKNEKVMCGY

DEPDC5

141

O75140
KDIWQGGVCPQKMAA

PRSS12

251

P56730
MWLKVGDCVFIKSHG

PBRM1

1156

Q86U86
KDPTMKLWCAAGVNL

MAPK8IP3

701

Q9UPT6
RIAMLWGSGKCKALT

NLRC4

181

Q9NPP4
GGDEQVAMKCAIWLA

RBCK1

21

Q9BYM8
VWKKGGSMQRTFLCI

DOP1B

616

Q9Y3R5
VMTCVWCNKKGLLAT

HERC1

3431

Q15751
QKTGMDNWIKLSGCQ

IFNAR1

66

P17181
TGIISWGEECAMKGK

F9

426

P00740
MGDEEVFSWLKCAKG

KDM3B

1071

Q7LBC6
LATGSAMGLWEVKNC

MRC2

621

Q9UBG0
KIADFGMCKENIWDG

PRKCB

481

P05771
GMCKENIWDGVTTKT

PRKCB

486

P05771
AWKGCKGSIQMAVCE

PLEKHA8

36

Q96JA3
MNIPEKGFKASLGWC

POGK

296

Q9P215
KGNNSLLTCMEDGLW

PAPPA

1321

Q13219
LGKGGMIWDHCKSRL

PLEKHM3

66

Q6ZWE6
SLNLWSIMKNCIGKE

OSBP

416

P22059
GMGKTTLAHRLCQKW

NLRC5

231

Q86WI3
EGWIMQFKISVGCKV

RELN

2751

P78509
GNSGLAEKCWMKAAE

IFT172

1306

Q9UG01
GHWKLGGMETVCKVS

SCYL3

136

Q8IZE3
WCGSKLSMEHADGKL

IRS2

746

Q9Y4H2
LVHWAKCLQKMGSGL

RGPD3

576

A6NKT7
ACKLAQANGWGVMVS

ENO1

356

P06733
AQAMKSEGGFIWACK

IDH1

256

O75874
KGTGVLQEEMKLCSW

COG1

306

Q8WTW3
SSSMWKKGAQGEILC

GATAD1

16

Q8WUU5
CEVLKKIWGSAQGMD

CDYL

571

Q9Y232
LSNKSICIMQKWGGK

HAS2

176

Q92819
MEGNIGIKGCEFKSW

C7orf77

26

A4D0Y5
CKVDKNLNCGMWGSS

DENND4C

176

Q5VZ89
MASKKVCIVGSGNWG

GPD1

1

P21695
LMCSFLQLIGDKWGK

FGD2

546

Q7Z6J4
DKGLAKMAKAWANQC

GLIPR1L1

61

Q6UWM5
WNNKMVKTAGLCSTG

GCNA

546

Q96QF7
EGGAVKLWDQEMKRC

EML6

1621

Q6ZMW3
MYVTGSKDGCIKLWD

CSTF1

276

Q05048
NCKMGGALWKVETDV

PIWIL3

631

Q7Z3Z3
GWDKKDGDVVCRMLG

SCARA5

421

Q6ZMJ2
LLVHWAKCLQKMGRG

RGPD1

566

P0DJD0
WMDADLACQKRPSGK

REG3G

61

Q6UW15
IGSDWKNACAMLKDG

POFUT1

241

Q9H488
IMGKKACIQLVSGSW

OR10J4

136

P0C629
MSWQVCGKLAAACAI

OR10R2

156

Q8NGX6
WIVCTGLKQQMESGK

NLRP3

416

Q96P20
WKGNSGSCLMAKALH

NUTM2A

36

Q8IVF1
NKMSGSSRKGCLWAL

FOXN4

256

Q96NZ1
WIGCGAHLSKPMEKL

MRPS16

76

Q9Y3D3
PDNSGWMCATGNKIK

TAFA1

111

Q7Z5A9
LVHWAKCLQKMGSGL

RGPD4

576

Q7Z3J3
ALCKPASKSMQEGWG

TNRC6C

866

Q9HCJ0
VHWAKCLQKMGRGLN

RGPD2

576

P0DJD1
MDAGSVLMLWVGKNC

SEC24A

986

O95486
GGSLMCRNKKGAWTL

OVCH2

241

Q7RTZ1
LKAATWKVLNCSGHM

HIF3A

181

Q9Y2N7
ACKLKMSNWQGAIDS

PPID

281

Q08752
FILCDKLANGGVSMW

HUS1

41

O60921
KAGCQVASTMLVWSK

NEU1

161

Q99519
ELSLFWTGQGRAKMC

SPPL2C

521

Q8IUH8
LNKSGAWKIMGFDFC

SCYL2

186

Q6P3W7
GVGKTTLAKKCMLDW

NLRP7

181

Q8WX94
CKGDMGGARTLQRKW

SEMA4C

261

Q9C0C4
LDGCIRSWNLMKQGA

PROS1

446

P07225
ETGLICATYWGMKIK

ACSM1

371

Q08AH1
GWKEFLMGCLLGQKL

ANKUB1

161

A6NFN9
KAGCSNWKRILMVLN

CHST9

221

Q7L1S5
GCVSWVEMKKAISNL

CLCNKA

666

P51800
GCVSWVEMKKAISNL

CLCNKB

666

P51801
IDSWMGKGAAKLRVA

RECQL

516

P46063
STQWNLVMEKLKCCG

TSPAN16

141

Q9UKR8
AAGLLWKFMGSKCSN

TMPRSS2

101

O15393
MNLMNWECAIPGKKG

UBE2I

36

P63279
KDMLKTAWLQGGVAC

ROM1

316

Q03395
AQVMFQCLWKSCGKV

SLC2A4RG

196

Q9NR83
GIKGACWIYDNIKMA

SLCO4C1

651

Q6ZQN7
GYIWMGTASLKEKLC

VPS16

241

Q9H269
GFMKQWKARLGCGLE

TRAF1

121

Q13077
WTVCGQKMSKSLGNV

MARS2

341

Q96GW9
ADCMSWLVQGGKEQK

TGM5

401

O43548
GECGKGFKWSLNLDM

ZNF234

571

Q14588
CGKGFKWSLNLDMHQ

ZNF226

676

Q9NYT6
ATGREMHGKNWSKLC

TPPP

66

O94811
VMECGNIDLNSWLKK

TTK

601

P33981
VTLMKWGKKVACGSS

WDR55

216

Q9H6Y2
DSNWCVGAVLEKKMP

TOMM40L

266

Q969M1
GTKFCSGSWDKMLKI

WDR12

201

Q9GZL7
QPKTMWHQDKEGLCG

USP6

246

P35125
ASWGQGGKKQMKCSL

TNRC6B

1036

Q9UPQ9
LALWRQQGAGMTDKC

ZSWIM4

316

Q9H7M6
NCDGHSMTLGWKVPK

MYOM2

721

P54296