Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATPase-coupled intramembrane lipid transporter activity

ABCA2 ABCA12 ABCA7

5.52e-0528533GO:0140326
GeneOntologyMolecularFunctioncAMP-dependent protein kinase activity

PRKACA PRKACB

1.44e-047532GO:0004691
GeneOntologyMolecularFunctionATP hydrolysis activity

ABCA2 KIF1A ABCA12 DYNC2H1 ABCA7 DYNC1H1 HSP90AA2P

1.57e-04441537GO:0016887
GeneOntologyMolecularFunctioncyclic nucleotide-dependent protein kinase activity

PRKACA PRKACB

2.46e-049532GO:0004690
GeneOntologyMolecularFunctionABC-type transporter activity

ABCA2 ABCA12 ABCA7

2.98e-0449533GO:0140359
GeneOntologyMolecularFunctionAMP-activated protein kinase activity

PRKACA PRKACB

3.07e-0410532GO:0004679
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ABCA2 ABCA12 ABCA7

3.36e-0451533GO:0140303
GeneOntologyMolecularFunctionfloppase activity

ABCA2 ABCA7

8.10e-0416532GO:0140328
GeneOntologyMolecularFunctionmicrotubule motor activity

KIF1A DYNC2H1 DYNC1H1

8.52e-0470533GO:0003777
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

ABCA2 KIF1A ABCA12 DYNC2H1 RASL11A ABCA7 DYNC1H1 HSP90AA2P

9.37e-04775538GO:0017111
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DYNC2H1 DYNC1H1

1.03e-0318532GO:0008569
GeneOntologyMolecularFunctionATP-dependent activity

ABCA2 KIF1A ABCA12 DYNC2H1 ABCA7 DYNC1H1 HSP90AA2P

1.13e-03614537GO:0140657
GeneOntologyMolecularFunctionprimary active transmembrane transporter activity

CYC1 ABCA2 ABCA12 ABCA7

1.27e-03178534GO:0015399
GeneOntologyMolecularFunctionpyrophosphatase activity

ABCA2 KIF1A ABCA12 DYNC2H1 RASL11A ABCA7 DYNC1H1 HSP90AA2P

1.56e-03839538GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

ABCA2 KIF1A ABCA12 DYNC2H1 RASL11A ABCA7 DYNC1H1 HSP90AA2P

1.57e-03840538GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

ABCA2 KIF1A ABCA12 DYNC2H1 RASL11A ABCA7 DYNC1H1 HSP90AA2P

1.57e-03840538GO:0016818
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DYNC2H1 DYNC1H1

2.50e-0328532GO:0051959
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCA2 ABCA12 ABCA7

3.04e-03109533GO:0042626
GeneOntologyMolecularFunctioncytoskeletal motor activity

KIF1A DYNC2H1 DYNC1H1

3.80e-03118533GO:0003774
GeneOntologyBiologicalProcesshigh-density lipoprotein particle assembly

PRKACA PRKACB ABCA7

4.25e-0613523GO:0034380
GeneOntologyBiologicalProcessneural tube development

NF1 MTHFD1 BRPF1 PRKACA PRKACB STIL

1.15e-05202526GO:0021915
GeneOntologyBiologicalProcessneural tube formation

MTHFD1 BRPF1 PRKACA PRKACB STIL

2.18e-05134525GO:0001841
GeneOntologyBiologicalProcessprotein localization to cell surface

ABCA2 ABCA12 ABCA7 VCL

4.69e-0579524GO:0034394
GeneOntologyBiologicalProcessembryonic epithelial tube formation

MTHFD1 BRPF1 PRKACA PRKACB STIL

4.96e-05159525GO:0001838
GeneOntologyBiologicalProcessplasma lipoprotein particle assembly

PRKACA PRKACB ABCA7

5.27e-0529523GO:0034377
GeneOntologyBiologicalProcessepithelial tube formation

MTHFD1 BRPF1 PRKACA PRKACB STIL

7.40e-05173525GO:0072175
GeneOntologyBiologicalProcessprotein-lipid complex assembly

PRKACA PRKACB ABCA7

7.82e-0533523GO:0065005
GeneOntologyBiologicalProcesstube formation

MTHFD1 BRPF1 PRKACA PRKACB STIL

1.07e-04187525GO:0035148
GeneOntologyBiologicalProcessmorphogenesis of embryonic epithelium

MTHFD1 BRPF1 PRKACA PRKACB STIL

1.15e-04190525GO:0016331
GeneOntologyBiologicalProcesspositive regulation of spindle assembly

STIL DYNC1H1

1.73e-048522GO:1905832
GeneOntologyBiologicalProcessneural tube closure

MTHFD1 PRKACA PRKACB STIL

1.89e-04113524GO:0001843
GeneOntologyBiologicalProcesstube closure

MTHFD1 PRKACA PRKACB STIL

1.95e-04114524GO:0060606
GeneOntologyBiologicalProcessprimary neural tube formation

MTHFD1 PRKACA PRKACB STIL

2.38e-04120524GO:0014020
GeneOntologyBiologicalProcessregulation of protein localization to cell surface

ABCA2 ABCA12 ABCA7

2.89e-0451523GO:2000008
GeneOntologyBiologicalProcesssynaptic transmission, glutamatergic

NF1 PRKACA GRID1 ALS2

3.42e-04132524GO:0035249
GeneOntologyBiologicalProcessplasma lipoprotein particle organization

PRKACA PRKACB ABCA7

3.61e-0455523GO:0071827
GeneOntologyBiologicalProcessregulation of cholesterol efflux

ABCA2 ABCA12 ABCA7

3.81e-0456523GO:0010874
GeneOntologyBiologicalProcessprotein-lipid complex organization

PRKACA PRKACB ABCA7

4.45e-0459523GO:0071825
GeneOntologyBiologicalProcesslipid translocation

ABCA2 ABCA12 ABCA7

4.67e-0460523GO:0034204
GeneOntologyBiologicalProcessregulation of intracellular lipid transport

ABCA2 ABCA12

4.78e-0413522GO:0032377
GeneOntologyBiologicalProcessregulation of membrane lipid distribution

ABCA2 ABCA12 ABCA7

5.91e-0465523GO:0097035
GeneOntologyBiologicalProcessphospholipid efflux

ABCA12 ABCA7

6.41e-0415522GO:0033700
GeneOntologyCellularComponentsecretory vesicle

KIF1A ABCA12 PRAMEF22 CTSC SPTBN2 VPS13A PRKACA PSMD2 COPS5 DYNC1H1 VCL

2.03e-0412465211GO:0099503
GeneOntologyCellularComponentcAMP-dependent protein kinase complex

PRKACA PRKACB

2.70e-0410522GO:0005952
GeneOntologyCellularComponentmicrotubule organizing center

ABCA2 CTSC PRKACA PRKACB NLRC5 ALS2 STIL NLRC3 DYNC1H1

3.95e-04919529GO:0005815
GeneOntologyCellularComponentcentrosome

CTSC PRKACA PRKACB NLRC5 ALS2 STIL NLRC3 DYNC1H1

5.85e-04770528GO:0005813
GeneOntologyCellularComponentsecretory granule

KIF1A ABCA12 PRAMEF22 CTSC VPS13A PRKACA PSMD2 DYNC1H1 VCL

8.04e-041014529GO:0030141
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

KIF1A DYNC2H1 PRKACA CFAP74 DYNC1H1

1.13e-03317525GO:0032838
GeneOntologyCellularComponentsecretory granule lumen

CTSC VPS13A PSMD2 DYNC1H1 VCL

1.26e-03325525GO:0034774
GeneOntologyCellularComponentcytoplasmic vesicle lumen

CTSC VPS13A PSMD2 DYNC1H1 VCL

1.35e-03330525GO:0060205
GeneOntologyCellularComponentvesicle lumen

CTSC VPS13A PSMD2 DYNC1H1 VCL

1.38e-03332525GO:0031983
GeneOntologyCellularComponentcytoplasmic dynein complex

DYNC2H1 DYNC1H1

1.62e-0324522GO:0005868
GeneOntologyCellularComponentmotile cilium

DYNC2H1 PRAMEF22 VPS13A PRKACA CFAP74

1.86e-03355525GO:0031514
GeneOntologyCellularComponentcytoplasmic region

KIF1A DYNC2H1 PRKACA CFAP74 DYNC1H1

1.97e-03360525GO:0099568
GeneOntologyCellularComponent9+2 motile cilium

DYNC2H1 VPS13A PRKACA CFAP74

2.89e-03238524GO:0097729
DomainABC_A

ABCA2 ABCA12 ABCA7

3.90e-0612503IPR026082
DomainAAA+_ATPase

ABCA2 ABCA12 DYNC2H1 ABCA7 DYNC1H1

4.07e-05144505IPR003593
DomainAAA

ABCA2 ABCA12 DYNC2H1 ABCA7 DYNC1H1

4.07e-05144505SM00382
DomainABC_transporter_CS

ABCA2 ABCA12 ABCA7

1.93e-0442503IPR017871
DomainDHC_N1

DYNC2H1 DYNC1H1

1.95e-048502PF08385
DomainDynein_heavy_dom-1

DYNC2H1 DYNC1H1

1.95e-048502IPR013594
DomainABC_tran

ABCA2 ABCA12 ABCA7

2.87e-0448503PF00005
DomainABC_TRANSPORTER_2

ABCA2 ABCA12 ABCA7

2.87e-0448503PS50893
DomainABC_TRANSPORTER_1

ABCA2 ABCA12 ABCA7

3.05e-0449503PS00211
DomainABC_transporter-like

ABCA2 ABCA12 ABCA7

3.24e-0450503IPR003439
DomainP-loop_NTPase

ABCA2 KIF1A ABCA12 DYNC2H1 MTHFD1 RASL11A NLRC5 ABCA7 DYNC1H1

3.68e-04848509IPR027417
DomainCRAL_TRIO_2

NF1 MCF2L2

4.56e-0412502PF13716
DomainDynein_heavy_chain_D4_dom

DYNC2H1 DYNC1H1

6.26e-0414502IPR024317
DomainDynein_HC_stalk

DYNC2H1 DYNC1H1

6.26e-0414502IPR024743
DomainDynein_heavy_dom-2

DYNC2H1 DYNC1H1

6.26e-0414502IPR013602
DomainDHC_N2

DYNC2H1 DYNC1H1

6.26e-0414502PF08393
DomainMT

DYNC2H1 DYNC1H1

6.26e-0414502PF12777
DomainAAA_8

DYNC2H1 DYNC1H1

6.26e-0414502PF12780
DomainATPase_dyneun-rel_AAA

DYNC2H1 DYNC1H1

6.26e-0414502IPR011704
DomainAAA_5

DYNC2H1 DYNC1H1

6.26e-0414502PF07728
DomainDHC_fam

DYNC2H1 DYNC1H1

7.21e-0415502IPR026983
DomainDynein_heavy_dom

DYNC2H1 DYNC1H1

7.21e-0415502IPR004273
DomainDynein_heavy

DYNC2H1 DYNC1H1

7.21e-0415502PF03028
Domain-

ABCA2 ABCA12 DYNC2H1 MTHFD1 RASL11A NLRC5 ABCA7 DYNC1H1

7.57e-047465083.40.50.300
DomainPH

KIF1A DOCK9 SPTBN2 MCF2L2 ALS2

8.64e-04278505SM00233
DomainPH_DOMAIN

KIF1A DOCK9 SPTBN2 MCF2L2 ALS2

8.78e-04279505PS50003
DomainPH_domain

KIF1A DOCK9 SPTBN2 MCF2L2 ALS2

8.92e-04280505IPR001849
DomainNACHT

NLRC5 NLRC3

1.71e-0323502PS50837
DomainNACHT_NTPase

NLRC5 NLRC3

1.71e-0323502IPR007111
DomainSEC14

NF1 MCF2L2

2.03e-0325502SM00516
DomainTHIOL_PROTEASE_CYS

CTSC CAPN5

2.19e-0326502PS00139
DomainTHIOL_PROTEASE_ASN

CTSC CAPN5

2.36e-0327502PS00640
DomainTHIOL_PROTEASE_HIS

CTSC CAPN5

2.36e-0327502PS00639
DomainCRAL_TRIO

NF1 MCF2L2

2.36e-0327502PS50191
DomainPept_cys_AS

CTSC CAPN5

2.54e-0328502IPR000169
DomainCRAL-TRIO_dom

NF1 MCF2L2

2.54e-0328502IPR001251
DomainSpectrin/alpha-actinin

SPTBN2 MCF2L2

3.31e-0332502IPR018159
DomainSPEC

SPTBN2 MCF2L2

3.31e-0332502SM00150
Domain-

KIF1A DOCK9 SPTBN2 MCF2L2 ALS2

3.83e-033915052.30.29.30
PathwayWP_VASOPRESSINREGULATED_WATER_REABSORPTION

DYNC2H1 PRKACA PRKACB DYNC1H1

6.95e-0644404M42554
PathwayKEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION

DYNC2H1 PRKACA PRKACB DYNC1H1

6.95e-0644404M9011
PathwayREACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT

UBC ABCA2 ABCA12 PSMD2 ABCA7

8.36e-0699405MM14986
PathwayREACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT

UBC ABCA2 ABCA12 PSMD2 ABCA7

1.01e-05103405M758
PathwayREACTOME_HEDGEHOG_OFF_STATE

UBC DYNC2H1 PRKACA PRKACB PSMD2

1.11e-05105405MM15206
PathwayREACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS

ABCA2 ABCA12 ABCA7

1.40e-0517403MM14552
PathwayREACTOME_HEDGEHOG_OFF_STATE

UBC DYNC2H1 PRKACA PRKACB PSMD2

1.59e-05113405M27471
PathwayREACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS

ABCA2 ABCA12 ABCA7

1.68e-0518403M524
PathwayREACTOME_GLI3_IS_PROCESSED_TO_GLI3R_BY_THE_PROTEASOME

UBC PRKACA PRKACB PSMD2

1.97e-0557404MM15205
PathwayREACTOME_DEGRADATION_OF_GLI1_BY_THE_PROTEASOME

UBC PRKACA PRKACB PSMD2

2.42e-0560404M27470
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

UBC NF1 SPTBN2 PRKACA PRKACB PSMD2 VCL

2.74e-05318407MM15278
PathwayREACTOME_SIGNALING_BY_ROBO_RECEPTORS

UBC RPL37 PRKACA PRKACB PSMD2 RPL19

3.16e-05218406M2780
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

UBC NF1 SPTBN2 PRKACA PRKACB PSMD2 VCL

3.27e-05327407M27565
PathwayREACTOME_SIGNALING_BY_HEDGEHOG

UBC DYNC2H1 PRKACA PRKACB PSMD2

4.03e-05137405MM15182
PathwayREACTOME_MAPK6_MAPK4_SIGNALING

UBC PRKACA PRKACB PSMD2

5.25e-0573404MM15285
PathwayREACTOME_SIGNALING_BY_HEDGEHOG

UBC DYNC2H1 PRKACA PRKACB PSMD2

6.22e-05150405M27440
PathwayREACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS

PRKACA PRKACB

7.81e-055402M26988
PathwayREACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION

PRKACA PRKACB

1.17e-046402MM14628
PathwayREACTOME_MAPK6_MAPK4_SIGNALING

UBC PRKACA PRKACB PSMD2

1.35e-0493404M27572
PathwayKEGG_MEDICUS_REFERENCE_PKA_HOLOENZYME

PRKACA PRKACB

1.63e-047402M47896
PathwayREACTOME_HDL_ASSEMBLY

PRKACA PRKACB

1.63e-047402MM15560
PathwayREACTOME_HDL_ASSEMBLY

PRKACA PRKACB

2.17e-048402M27840
PathwayKEGG_ABC_TRANSPORTERS

ABCA2 ABCA12 ABCA7

2.59e-0444403M11911
PathwayREACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS

UBC PRKACA PRKACB PSMD2

2.77e-04112404MM15214
PathwayREACTOME_ROBO_RECEPTORS_BIND_AKAP5

PRKACA PRKACB

2.79e-049402M27877
PathwayREACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION

KIF1A DOCK9 PRKACA PRKACB

3.16e-04116404MM15715
PathwayKEGG_MEDICUS_REFERENCE_AVP_V2R_PKA_SIGNALING_PATHWAY

PRKACA PRKACB

3.48e-0410402M47648
PathwayREACTOME_REGULATION_OF_GLYCOLYSIS_BY_FRUCTOSE_2_6_BISPHOSPHATE_METABOLISM

PRKACA PRKACB

5.09e-0412402M27950
PathwayREACTOME_CREB1_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_ADENYLATE_CYCLASE

PRKACA PRKACB

5.09e-0412402M27363
PathwayWP_DOPAMINE_METABOLISM

PRKACA PRKACB

6.00e-0413402M39622
PathwayREACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS

UBC PRKACA PRKACB PSMD2

6.45e-04140404M27484
PathwayREACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE

UBC PRKACA PRKACB

7.13e-0462403MM14686
PathwayREACTOME_RAP1_SIGNALLING

PRKACA PRKACB

8.05e-0415402MM15019
PathwayKEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY

PRKACA PRKACB

8.05e-0415402M47794
PathwayREACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS

PRKACA PRKACB

8.05e-0415402MM15103
PathwayKEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY

PRKACA PRKACB

8.05e-0415402M47504
PathwayREACTOME_REGULATION_OF_RAS_BY_GAPS

UBC NF1 PSMD2

8.56e-0466403MM15261
PathwayKEGG_MEDICUS_REFERENCE_DRD1_GNAS_AC_PKA_SIGNALING_PATHWAY

PRKACA PRKACB

9.19e-0416402M47551
PathwayKEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY

PRKACA PRKACB

9.19e-0416402M47645
PathwayREACTOME_DARPP_32_EVENTS

PRKACA PRKACB

9.19e-0416402MM14699
PathwayKEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY

PRKACA PRKACB

9.19e-0416402M47650
PathwayREACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB

PRKACA PRKACB

9.19e-0416402MM14492
PathwayWP_TCA_CYCLE_AND_DEFICIENCY_OF_PYRUVATE_DEHYDROGENASE_COMPLEX_PDHC

PC OGDH

9.19e-0416402M39489
PathwayREACTOME_RAP1_SIGNALLING

PRKACA PRKACB

9.19e-0416402M923
PathwayREACTOME_REGULATION_OF_RAS_BY_GAPS

UBC NF1 PSMD2

9.33e-0468403M27539
PathwayREACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY

PRKACA PRKACB

1.04e-0317402MM15561
PathwayREACTOME_REGULATION_OF_NF_KAPPA_B_SIGNALING

UBC NLRC5

1.04e-0317402MM15702
PathwayREACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING

PRKACA PRKACB

1.04e-0317402M26995
PathwayKEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY

PRKACA PRKACB

1.04e-0317402M47544
PathwayREACTOME_CD209_DC_SIGN_SIGNALING

PRKACA PRKACB

1.04e-0317402MM15215
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

UBC RPL37 SPTBN2 PRKACA PRKACB PSMD2 RPL19

1.04e-03575407M29853
PathwayREACTOME_REGULATION_OF_NF_KAPPA_B_SIGNALING

UBC NLRC5

1.17e-0318402M45023
PathwayREACTOME_MUSCLE_CONTRACTION

GUCY1A1 PRKACA KCNK3 VCL

1.19e-03165404MM15026
PathwayREACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE

UBC PRKACA PRKACB

1.24e-0375403M27032
PathwayREACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY

PRKACA PRKACB

1.30e-0319402M27841
PathwayREACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION

KIF1A DOCK9 PRKACA PRKACB

1.33e-03170404M941
PathwayREACTOME_REGULATION_OF_EXPRESSION_OF_SLITS_AND_ROBOS

UBC RPL37 PSMD2 RPL19

1.39e-03172404M27876
PathwayREACTOME_ABC_TRANSPORTER_DISORDERS

UBC ABCA12 PSMD2

1.39e-0378403M27473
PathwayREACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB

PRKACA PRKACB

1.44e-0320402M759
PathwayWP_NICOTINE_EFFECT_ON_DOPAMINERGIC_NEURONS

PRKACA KCNK3

1.59e-0321402M39343
PathwayREACTOME_CD209_DC_SIGN_SIGNALING

PRKACA PRKACB

1.59e-0321402M27485
PathwayREACTOME_MEMBRANE_TRAFFICKING

UBC KIF1A CTSC SPTBN2 ALS2 COPS5 DYNC1H1

1.77e-03630407M11480
PathwayREACTOME_MITOTIC_G2_G2_M_PHASES

UBC PRKACA PSMD2 DYNC1H1

1.78e-03184404MM15145
PathwayREACTOME_REGULATION_OF_PLK1_ACTIVITY_AT_G2_M_TRANSITION

UBC PRKACA DYNC1H1

1.78e-0385403MM14906
PathwayREACTOME_GLUCOSE_METABOLISM

PRKACA PRKACB PC

1.78e-0385403M1870
PathwayREACTOME_REGULATION_OF_PLK1_ACTIVITY_AT_G2_M_TRANSITION

UBC PRKACA DYNC1H1

1.90e-0387403M27194
PathwayREACTOME_VESICLE_MEDIATED_TRANSPORT

UBC KIF1A CTSC SPTBN2 ALS2 COPS5 DYNC1H1

2.03e-03645407MM15232
PathwayREACTOME_TRIGLYCERIDE_CATABOLISM

PRKACA PRKACB

2.08e-0324402M10064
PathwayWP_EFFECTS_OF_MFN2_MUTATION

DYNC2H1 DYNC1H1

2.08e-0324402M48308
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY

PRKACA PRKACB

2.08e-0324402M47520
PathwayREACTOME_DARPP_32_EVENTS

PRKACA PRKACB

2.08e-0324402M751
PathwayKEGG_GAP_JUNCTION

GUCY1A1 PRKACA PRKACB

2.10e-0390403M4013
PathwayREACTOME_MITOTIC_G2_G2_M_PHASES

UBC PRKACA PSMD2 DYNC1H1

2.41e-03200404M864
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAI_AC_PKA_SIGNALING_PATHWAY

PRKACA PRKACB

2.44e-0326402M47553
PathwayREACTOME_CA_DEPENDENT_EVENTS

PRKACA PRKACB

2.44e-0326402MM14495
PathwayPID_IL3_PATHWAY

PRKACA PRKACB

2.44e-0326402M182
PathwayREACTOME_MUSCLE_CONTRACTION

GUCY1A1 PRKACA KCNK3 VCL

2.54e-03203404M5485
PathwayWP_INTRAFLAGELLAR_TRANSPORT_PROTEINS_BINDING_TO_DYNEIN

DYNC2H1 DYNC1H1

2.63e-0327402M39827
PathwayKEGG_MEDICUS_REFERENCE_CRHR_PKA_ACTH_SIGNALING_PATHWAY

PRKACA PRKACB

2.63e-0327402M47518
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_RASD1_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY

PRKACA PRKACB

2.63e-0327402M47519
PathwayREACTOME_GPER1_SIGNALING

PRKACA PRKACB

2.63e-0327402MM15664
PathwayREACTOME_HEMOSTASIS

THPO KIF1A GUCY1A1 DOCK9 PRKACA PRKACB VCL

2.71e-03679407M8395
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

UBC ABCA2 ABCA12 PRKACA PRKACB PSMD2 ABCA7

2.75e-03681407MM14985
PathwayKEGG_MEDICUS_REFERENCE_GHRHR_PKA_GH_SIGNALING_PATHWAY

PRKACA PRKACB

2.83e-0328402M47647
PathwayWP_LIPID_METABOLISM_PATHWAY

PRKACA PRKACB

3.04e-0329402M39762
PathwayKEGG_MEDICUS_REFERENCE_TSH_TG_SIGNALING_PATHWAY

PRKACA PRKACB

3.04e-0329402M47627
PathwayWP_CANNABINOID_RECEPTOR_SIGNALING

PRKACA PRKACB

3.04e-0329402M39676
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_ACTH_CORTISOL_SIGNALING_PATHWAY

PRKACA PRKACB

3.04e-0329402M47515
PathwayREACTOME_INTERLEUKIN_1_SIGNALING

UBC NLRC5 PSMD2

3.16e-03104403MM17224
PathwayKEGG_MEDICUS_REFERENCE_DYNEIN_RECRUITMENT_TO_THE_KINETOCHORE

DYNC2H1 DYNC1H1

3.25e-0330402M47889
PathwayWP_GPR143_IN_MELANOCYTES_AND_RETINAL_PIGMENT_EPITHELIUM_CELLS

PRKACA PRKACB

3.25e-0330402M42578
PathwayREACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS

PRKACA PRKACB

3.47e-0331402MM15094
PathwayWP_TCA_CYCLE

PC OGDH

3.47e-0331402MM15856
PathwayKEGG_MEDICUS_VARIANT_CYP11B1_CYP11B2_FUSION_TO_ACTH_CORTISOL_SIGNALING_PATHWAY

PRKACA PRKACB

3.47e-0331402M47507
PathwayKEGG_CITRATE_CYCLE_TCA_CYCLE

PC OGDH

3.47e-0331402M3985
PathwayREACTOME_INNATE_IMMUNE_SYSTEM

UBC CTSC PRKACA PRKACB NLRC5 PSMD2 NLRC3 DYNC1H1 VCL

3.69e-031128409M1036
PathwayKEGG_MEDICUS_REFERENCE_ACTH_CORTISOL_SIGNALING_PATHWAY

PRKACA PRKACB

3.69e-0332402M47506
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

PRKACA PRKACB

3.69e-0332402MM14983
PathwayREACTOME_ADAPTIVE_IMMUNE_SYSTEM

UBC CTSC SPTBN2 PRKACA PRKACB PSMD2 DYNC1H1

3.73e-03719407MM14540
PathwayREACTOME_VESICLE_MEDIATED_TRANSPORT

UBC KIF1A CTSC SPTBN2 ALS2 COPS5 DYNC1H1

3.90e-03725407M27507
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

UBC ABCA2 DYNC2H1 MTHFD1 BRPF1 PRKACA PSMD2 PC OGDH DYNC1H1 VCL

4.63e-08807551130575818
Pubmed

Control of PKA stability and signalling by the RING ligase praja2.

UBC PRKACA PRKACB

2.08e-07855321423175
Pubmed

Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.

ABCA2 ABCA12 ABCA7

2.08e-07855324293640
Pubmed

Ellis-van Creveld Syndrome

DYNC2H1 PRKACA PRKACB

3.12e-07955337903214
Pubmed

Network organization of the huntingtin proteomic interactome in mammalian brain.

CYC1 KIF1A MTHFD1 PRKACA PRKACB PSMD2 PC OGDH DYNC1H1

5.33e-0762155922794259
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

MTHFD1 CTSC PSMD2 OGDH DYNC1H1 VCL RPL19

1.18e-0634455730333137
Pubmed

Defining the membrane proteome of NK cells.

CYC1 ABCA2 NF1 MTHFD1 CTSC DOCK9 MARF1 PSMD2 DYNC1H1 RUSF1 RPL19

1.80e-061168551119946888
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

UBC SPTBN2 VPS13A PRKACA PRKACB MARF1 PSMD2 CFAP74 KRBA2 OGDH KIAA2012 RPL19

2.07e-061442551235575683
Pubmed

NUTM2A-CIC fusion small round cell sarcoma: a genetically distinct variant of CIC-rearranged sarcoma.

NUTM2A CIC

2.46e-06255228188754
Pubmed

Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase.

PRKACA PRKACB

2.46e-0625523023318
Pubmed

Global consequences of activation loop phosphorylation on protein kinase A.

PRKACA PRKACB

2.46e-06255219965870
Pubmed

Neurofibromin interacts with the cytoplasmic Dynein Heavy Chain 1 in melanosomes of human melanocytes.

NF1 DYNC1H1

2.46e-06255223583712
Pubmed

Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis.

PRKACA PRKACB

2.46e-06255212180908
Pubmed

Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct.

PRKACA PRKACB

2.46e-06255231678302
Pubmed

Inhibition of microtubules and dynein rescues human immunodeficiency virus type 1 from owl monkey TRIMCyp-mediated restriction in a cellular context-specific fashion.

DYNC2H1 DYNC1H1

2.46e-06255225502651
Pubmed

Genetic analysis of the cytoplasmic dynein subunit families.

DYNC2H1 DYNC1H1

2.46e-06255216440056
Pubmed

Systems-level identification of PKA-dependent signaling in epithelial cells.

PRKACA PRKACB

2.46e-06255228973931
Pubmed

Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors of the pancreatobiliary and other systems.

PRKACA PRKACB

2.46e-06255236152045
Pubmed

PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic Papillary Neoplasms Including Those With Atypical Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.

PRKACA PRKACB

2.46e-06255238841868
Pubmed

Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.

PRKACA PRKACB

2.46e-06255237871652
Pubmed

Molecular and behavioral effects of a null mutation in all PKA C beta isoforms.

PRKACA PRKACB

2.46e-06255212139926
Pubmed

Characterization of genomic clones coding for the C alpha and C beta subunits of mouse cAMP-dependent protein kinase.

PRKACA PRKACB

2.46e-0625522833513
Pubmed

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.

NF1 SPTBN2 HECTD4 PRKACB DYNC1H1

3.70e-0614755516959763
Pubmed

Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube.

DYNC2H1 PRKACA PRKACB

4.88e-062155322007132
Pubmed

Physiological and pathophysiological characteristics of ataxin-3 isoforms.

CYC1 UBC PSMD2 PC OGDH DYNC1H1

5.48e-0628155630455355
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

EIF2D BRPF1 SPTBN2 PRKACB STIL PC DYNC1H1 VCL RPL19

7.13e-0685355928718761
Pubmed

Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.

PRKACA PRKACB

7.36e-0635522342480
Pubmed

Recombinant human cytoplasmic dynein heavy chain 1 and 2: observation of dynein-2 motor activity in vitro.

DYNC2H1 DYNC1H1

7.36e-06355221723285
Pubmed

Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein.

PRKACA PRKACB

7.36e-06355212842892
Pubmed

Cytoplasmic dynein promotes HIV-1 uncoating.

DYNC2H1 DYNC1H1

7.36e-06355225375884
Pubmed

Involvement of the catalytic subunit of protein kinase A and of HA95 in pre-mRNA splicing.

PRKACA PRKACB

7.36e-06355217594903
Pubmed

Protein kinase A is central for forward transport of two-pore domain potassium channels K2P3.1 and K2P9.1.

PRKACA KCNK3

7.36e-06355221357689
Pubmed

A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning.

PRKACA PRKACB

7.36e-0635528548807
Pubmed

Epidermal growth factor receptor levels are reduced in mice with targeted disruption of the protein kinase A catalytic subunit.

PRKACA PRKACB

7.36e-06355218380891
Pubmed

Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles.

DYNC2H1 DYNC1H1

7.36e-0635528666668
Pubmed

The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits.

PRKACA PRKACB

7.36e-06355219383776
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ZGPAT ABCA2 DOCK9 HECTD4 NLRC5 GRID1 PC ABCA7 CIC DYNC1H1

8.03e-061105551035748872
Pubmed

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

UBC MTHFD1 SPTBN2 PSMD2 DYNC1H1 VCL RPL19

1.00e-0547755731300519
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

NF1 KIF1A DYNC2H1 MTHFD1 PRKACA PSMD2 PC OGDH DYNC1H1 VCL RPL19

1.20e-051425551130948266
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

CYC1 NF1 MTHFD1 SPTBN2 PRKACA PSMD2 PC OGDH DYNC1H1 VCL RPL19

1.24e-051431551137142655
Pubmed

USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.

MTHFD1 SPTBN2 PC DYNC1H1

1.29e-059055435654790
Pubmed

Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout.

THPO VCL

1.47e-05455217925492
Pubmed

Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype.

PRKACA PRKACB

1.47e-05455218385332
Pubmed

Cloning of a mouse protein kinase A catalytic subunit pseudogene and chromosomal mapping of C subunit isoforms.

PRKACA PRKACB

1.47e-0545527873880
Pubmed

Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway.

PRKACA PRKACB

1.47e-05455223116618
Pubmed

Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation.

PRKACA PRKACB

1.47e-05455215111495
Pubmed

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.

PRKACA PRKACB

1.47e-05455231112131
Pubmed

Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C.

PRKACA PRKACB

1.47e-05455223709216
Pubmed

Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome.

PRKACA PRKACB

1.47e-05455233058759
Pubmed

Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a.

PRKACA PRKACB

1.47e-05455221852354
Pubmed

COP9 subunits 4 and 5 target soluble guanylyl cyclase α1 and p53 in prostate cancer cells.

GUCY1A1 COPS5

2.45e-05555224725084
Pubmed

Inhibition of cullin RING ligases by cycle inhibiting factor: evidence for interference with Nedd8-induced conformational control.

UBC COPS5

2.45e-05555221903097
Pubmed

Developmentally acquired PKA localisation in mouse oocytes and embryos.

PRKACA PRKACB

2.45e-05555218367160
Pubmed

HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling.

PRKACA PRKACB

2.45e-05555212972513
Pubmed

Involvement of protein kinase A in patterning of the mouse somatosensory cortex.

PRKACA PRKACB

2.45e-05555216707791
Pubmed

Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways.

PRKACA PRKACB

2.45e-05555219483721
Pubmed

PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation.

PRKACA PRKACB

2.45e-05555228934360
Pubmed

HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction.

PRKACA PRKACB

2.45e-05555221745501
Pubmed

Influenza A virus uses the aggresome processing machinery for host cell entry.

UBC DYNC1H1

2.45e-05555225342804
Pubmed

Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts.

PRKACA PRKACB

2.45e-0555529540970
Pubmed

PKA-mediated stabilization of FoxH1 negatively regulates ERalpha activity.

PRKACA PRKACB

2.45e-05555219711044
Pubmed

Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controls.

PRKACA PRKACB

2.45e-05555219573263
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

UBC ABCA2 KIF1A SPTBN2 MCF2L2 HECTD4 PSMD2 PC COPS5 DYNC1H1

2.94e-051285551035914814
Pubmed

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.

CYC1 MTHFD1 PRKACA PSMD2 OGDH COPS5 DYNC1H1

3.18e-0557155737167062
Pubmed

Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis.

PRKACA PRKACB

3.67e-05655230385877
Pubmed

Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy.

PRKACA PRKACB

3.67e-05655217557924
Pubmed

Architectural DNA-binding properties of the spermatidal transition proteins 1 and 2.

PRKACA PRKACB

3.67e-0565529837753
Pubmed

Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation.

PRKACA PRKACB

3.67e-05655219197368
Pubmed

Distinct patterns of cAMP-dependent protein kinase gene expression in mouse brain.

PRKACA PRKACB

5.13e-0575522619996
Pubmed

Dynamic binding of PKA regulatory subunit RI alpha.

PRKACA PRKACB

5.13e-05755216407073
Pubmed

Phosphorylation of HIV Nef by cAMP-dependent protein kinase.

PRKACA PRKACB

5.13e-05755215629779
Pubmed

Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome.

UBC PSMD2

5.13e-05755230664872
Pubmed

Multiple mouse chromosomal loci for dynein-based motility.

NF1 DYNC2H1 DYNC1H1

5.78e-05475538812413
Pubmed

An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity.

UBC PSMD2

6.83e-05855216973439
Pubmed

CCL3L1 prevents gp120-induced neuron death via the CREB cell signaling pathway.

PRKACA PRKACB

6.83e-05855219100722
Pubmed

Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alpha.

PRKACA PRKACB

6.83e-0585528794865
Pubmed

HIV-1 uncoating is facilitated by dynein and kinesin 1.

DYNC2H1 DYNC1H1

6.83e-05855225231297
Pubmed

HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.

KIF1A DYNC1H1

6.83e-05855225818806
Pubmed

Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).

PRKACA PRKACB

6.83e-05855212628924
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

UBC MARF1 PSMD2 KIAA2012 DYNC1H1

7.13e-0527255531010829
Pubmed

Repression of rRNA transcription by PARIS contributes to Parkinson's disease.

CYC1 MTHFD1 PSMD2 PC DYNC1H1

7.13e-0527255525315684
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

NF1 KIF1A SPTBN2 PSMD2 DYNC1H1 VCL RPL19

7.40e-0565355722586326
Pubmed

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.

UBC PRKACA PRKACB PSMD2 OGDH CIC DYNC1H1

8.29e-0566555730457570
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

NF1 SPTBN2 PRKACA PRKACB DYNC1H1

8.31e-0528155528706196
Pubmed

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.

PRKACA PRKACB STIL DYNC1H1

8.61e-0514655421399614
Pubmed

Structural basis for a reciprocal regulation between SCF and CSN.

UBC COPS5

8.78e-05955222959436
Pubmed

Protein kinase A deficiency causes axially localized neural tube defects in mice.

PRKACA PRKACB

8.78e-05955211886853
Pubmed

Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.

PRKACA PRKACB

8.78e-0595527688126
Pubmed

Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death.

UBC COPS5

8.78e-05955225349427
Pubmed

HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition.

PRKACA PRKACB

1.10e-041055220433920
Pubmed

A human MAP kinase interactome.

ZGPAT UBC SPTBN2 PRKACA COPS5 CIC

1.17e-0448655620936779
Pubmed

Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability.

UBC MTHFD1 PSMD2 PC

1.23e-0416055423798571
Pubmed

Neural crest-specific loss of Prkar1a causes perinatal lethality resulting from defects in intramembranous ossification.

PRKACA PRKACB

1.34e-041155220534695
Pubmed

Identification of neuroglobin-interacting proteins using yeast two-hybrid screening.

CYC1 UBC

1.34e-041155222079573
Pubmed

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.

GUCY1A1 HECTD4

1.34e-041155222751097
Pubmed

MARF1 regulates essential oogenic processes in mice.

MARF1 RPL19

1.34e-041155222442484
Pubmed

ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.

UBC MTHFD1 PSMD2 VCL

1.41e-0416655435687106
Pubmed

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

PRKACA PRKACB

1.60e-041255210830164
Pubmed

NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.

UBC PSMD2

1.60e-041255222466964
Pubmed

Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase.

PRKACA VCL

1.60e-041255215465019
Cytoband3q27.1

MCF2L2 PSMD2

4.85e-04275523q27.1
CytobandEnsembl 112 genes in cytogenetic band chr3q27

THPO MCF2L2 PSMD2

5.00e-04128553chr3q27
Cytoband2q33.1

ALS2 KIAA2012

1.73e-03515522q33.1
Cytoband1p31.1

TYW3 PRKACB

3.32e-03715521p31.1
GeneFamilyATP binding cassette subfamily A

ABCA2 ABCA12 ABCA7

1.99e-0614333805
GeneFamilyDyneins, cytoplasmic

DYNC2H1 DYNC1H1

2.49e-0413332538
GeneFamilyNLR family

NLRC5 NLRC3

9.44e-0425332666
GeneFamilyL ribosomal proteins

RPL37 RPL19

3.90e-0351332729
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

KIF1A DOCK9 SPTBN2

6.18e-03206333682
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

MCF2L2 ALS2

6.44e-0366332722
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

KIF1A MARF1 GRID1 PC DYNC1H1

2.64e-06177555e8ab340b20cd41554c3841fe980e078e878af35f
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF1A DYNC2H1 VPS13A PC DYNC1H1

4.24e-061955553e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF1A DYNC2H1 VPS13A PC DYNC1H1

4.24e-061955557796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell343B-Myeloid-Dendritic-cDC1|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

SRRM5 RPL37 NLRC5 RPL19

4.67e-05161554537a1d86de99a493b0345ca0f760994260e97049
ToppCellIPF-Epithelial-PNEC|Epithelial / Disease state, Lineage and Cell class

KCNV1 CALCB KIF1A KCNK3

4.79e-05162554865d0e215d54fb1412f00cf0649c71c2f1878e57
ToppCell(06)_Krt4/13+|World / shred by cell type and Timepoint

CALCB CTSC CAPN5 VCL

6.90e-0517855446efdf03aa1317bc600138e871509b995e773cce
ToppCellSmart-seq2-blood_(Smart-seq2)-lymphocytic-T_lymphocytic-CD4-positive,_alpha-beta_memory_T_cell|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RPL37 MCF2L2 VPS13A RPL19

7.68e-051835544c566be2dbbac36936f065af57b524403aae9711
ToppCelldroplet-Limb_Muscle-nan-21m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GUCY1A1 RASL11A KCNK3 KIAA2012

8.35e-05187554accb8a78b885703a27d4b560f0053f03d82ff3af
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INTS6 UBC GUCY1A1 RASL11A

8.52e-051885545e13725136114e42d3b59647cf25e0f3c53abb54
ToppCellCOPD-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

DYNC2H1 CFAP74 KIAA2012 NLRC3

8.70e-051895543e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GUCY1A1 RASL11A KCNK3 VCL

8.88e-05190554951e067d14412db67dc3babcdf61e41717d7b429
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GUCY1A1 RASL11A KCNK3 VCL

8.88e-051905541ab3f19f1ce9f58e5125135704d94655a2e330a0
ToppCellFibroblasts-CD55+_Fibroblasts|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

VPS13A KCNK3 OGDH ABCA7

8.88e-05190554b4088128f5acf53f43244c9af9fe44e033f1a57a
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GUCY1A1 RASL11A KCNK3 KIAA2012

9.06e-051915548e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GUCY1A1 RASL11A KCNK3 VCL

9.25e-0519255488472b99970ba0decbf87164fc241a1c77b3b389
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF1A MTHFD1 PRKACB PC

9.25e-051925545b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCelldroplet-Bladder-nan-24m-Epithelial-luminal_bladder_epithelial_cell_(umbrella_cell)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPL37 TMEM45B CAPN5 RPL19

9.43e-051935545b30bbb354c69f684a1c8d2c68e9b3424d759e8d
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

DYNC2H1 CFAP74 KIAA2012 NLRC3

9.43e-05193554ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GUCY1A1 RASL11A KCNK3 VCL

9.62e-0519455452ecec2618c3bb5fdd7fb06b5a40bd6f0aedfe1d
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CTSC PRKACB NLRC5 NLRC3

9.82e-0519555414a6466524c22920daa622fbc710daf1defb46c3
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

GUCY1A1 RASL11A KCNK3 VCL

1.04e-041985542d0c14f8cabab99bc6d7c27685437c78841c7245
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

GUCY1A1 RASL11A KCNK3 VCL

1.04e-04198554c9c96066c7fa897b583657f0b77ea093920ae9ba
ToppCellfacs-Tongue-nan-3m-Epithelial-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPL37 MTHFD1 OGDH VCL

1.06e-041995548d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_CTL|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PRKACB NLRC5 NLRC3 RPL19

1.06e-0419955454b64f01e7a73a88bd92b6d4e73cccde60396b2d
ToppCellTransverse-(1)_T_cell-(14)_Tcm|Transverse / shred on region, Cell_type, and subtype

RPL37 TMEM45B NLRC5 RPL19

1.06e-04199554c885c53cc8d1382acc176c8029430d218ac41cc5
ToppCellSepsis-ICU-NoSEP-Lymphocyte-T/NK-CD4+_Tem|ICU-NoSEP / Disease, condition lineage and cell class

SRRM5 RPL37 MCF2L2 RPL19

1.06e-041995543382dfd446e362c94d8d92a3d78c3d0022cbe69c
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

GUCY1A1 RASL11A KCNK3 VCL

1.06e-04199554aacd3ffa40a6e6f435aa9be5b959d88812eb69d4
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

UBC SPTBN2 KCNK3 RPL19

1.06e-0419955456046a9f156d575c8810b7951043af471fb4c2ab
ToppCellTransverse-T_cell-Tcm|Transverse / Region, Cell class and subclass

RPL37 TMEM45B NLRC5 RPL19

1.06e-04199554b98964bdc707761dad94823510036e0af0ed1242
DrugPu x

UBC PSMD2 HSP90AA2P

2.51e-076543CID000448976
Diseasediastolic blood pressure, unipolar depression

GUCY1A1 HECTD4 KCNK3

2.03e-0530523EFO_0003761, EFO_0006336
Diseasechildhood gender nonconformity

SPTBN2 GRID1 PC

6.06e-0543523EFO_0020103
Diseasediastolic blood pressure, alcohol consumption measurement

GUCY1A1 HECTD4 KCNK3

1.20e-0454523EFO_0006336, EFO_0007878
DiseaseColorectal Carcinoma

NF1 ABCA12 RASL11A SPTBN2 MCF2L2 VPS13A GRID1

2.21e-04702527C0009402
DiseaseSarcoma

NF1 CIC

6.26e-0421522C1261473
Diseasemean corpuscular hemoglobin concentration

CYC1 ZGPAT VPS13A HECTD4 PSMD2 KIAA2012 ABCA7 RUSF1

6.56e-041105528EFO_0004528
Diseasemean arterial pressure, alcohol drinking

GUCY1A1 HECTD4 KCNK3

6.98e-0498523EFO_0004329, EFO_0006340
Diseasebrain ischemia (biomarker_via_orthology)

CTSC PRKACA PRKACB

7.84e-04102523DOID:2316 (biomarker_via_orthology)
DiseaseIntrahepatic Cholangiocarcinoma

PRKACA PRKACB

8.20e-0424522C0345905
DiseaseExtrahepatic Cholangiocarcinoma

PRKACA PRKACB

8.20e-0424522C3805278
DiseaseCholangiocarcinoma

PRKACA PRKACB

9.64e-0426522C0206698
Diseasevon Willebrand factor measurement, coronary artery disease

GUCY1A1 DYNC2H1 HECTD4

1.19e-03118523EFO_0001645, EFO_0004629
Diseasediastolic blood pressure, alcohol drinking

GUCY1A1 HECTD4 KCNK3

1.19e-03118523EFO_0004329, EFO_0006336
Diseaseresistin measurement

TYW3 PSMD2

1.20e-0329522EFO_0004819
Diseasesystolic blood pressure, alcohol drinking

GUCY1A1 HECTD4 KCNK3

1.51e-03128523EFO_0004329, EFO_0006335
DiseaseVasodilators used in cardiac diseases use measurement

GUCY1A1 DYNC2H1

1.65e-0334522EFO_0009926
DiseaseSpinocerebellar Ataxia Type 2

SPTBN2 CIC

1.65e-0334522C0752121
DiseaseSpinocerebellar Ataxia Type 1

SPTBN2 CIC

1.65e-0334522C0752120
DiseaseSpinocerebellar Ataxia Type 5

SPTBN2 CIC

1.65e-0334522C0752123
DiseaseSpinocerebellar Ataxia Type 7

SPTBN2 CIC

1.65e-0334522C0752125
DiseaseSpinocerebellar Ataxia Type 6 (disorder)

SPTBN2 CIC

1.65e-0334522C0752124
DiseaseAtaxia, Spinocerebellar

SPTBN2 CIC

1.65e-0334522C0087012
Diseaseserine measurement

OGDH DYNC1H1

1.75e-0335522EFO_0009774
DiseaseSpinocerebellar Ataxia Type 4

SPTBN2 CIC

1.75e-0335522C0752122

Protein segments in the cluster

PeptideGeneStartEntry
GRGSFMLGLETHDRK

COPS5

281

Q92905
MLTSGLKGRGFSVLH

EIF2D

156

P41214
HRLAGLLSRSGGMVK

CALCB

91

P10092
MRHGHGLLRSGKLTS

ALS2

1131

Q96Q42
HRHKRVGTLSGGMKR

ABCA12

1471

Q86UK0
ERMLKVHSRGGLISA

CAPN5

216

O15484
SGLSRGRKVMLSALG

CYC1

51

P08574
RVTRAKHLQLMGGLS

ABCA7

1561

Q8IZY2
ETGIKVRSRSHGLSM

INTS6

481

Q9UL03
RIKTLGTGSFGRVML

PRKACA

46

P17612
MVGTLGRLAFHGLLK

NLRC3

396

Q7RTR2
TGLHSLSTFRGLMKR

KCNK3

376

O14649
RMLKLGRHSTGLRSL

KCNV1

321

Q6PIU1
GRHSTGLRSLGMTIT

KCNV1

326

Q6PIU1
MTLSIRQLGRGSHRK

MCF2L2

906

Q86YR7
MFTLSLLSRGHGKLG

KIAA2012

1

Q0VF49
AIRGMLKTFGLHGVV

HECTD4

2361

Q9Y4D8
LLGKAGMGKTTLAHR

NLRC5

226

Q86WI3
MGRRGVHGGILNKTV

PFN3

111

P60673
IHGGLSRILKTRGEM

OGDH

631

Q02218
MSAGGRLGRHKLTTR

DYNC2H1

2406

Q8NCM8
RKKTLGTGSFGRVML

PRKACB

46

P22694
SKVTEVMHSGRRLLG

DOCK9

1766

Q9BZ29
LTLGDMIRRSGGHSR

CTSC

196

P53634
RHSLVQTLSGGMKRK

ABCA2

1116

Q9BZC7
MRKVVLITGASSGIG

HSD17B7

1

P56937
GMGSKRLLTLTHRAQ

MARF1

1161

Q9Y4F3
LAKRGGRTMAITPRH

DYNC1H1

3161

Q14204
GGRSMLDTIKKGHIT

GRID1

361

Q9ULK0
GTMSRSRSGKLHGLS

MENT

216

Q9BUN1
VLVATVRALKMHGGG

MTHFD1

696

P11586
KRGTLTLTLMGTGVA

CFAP74

1326

Q9C0B2
TGERMGRGTKVILHL

HSP90AA2P

176

Q14568
SILRSGNRIIMGKSH

KIF1A

576

Q12756
HLSIGHGGRTRMLKE

KRBA2

201

Q6ZNG9
SQGRGRAHTGMARSK

NUTM2A

681

Q8IVF1
KTILRAATHGLMLGA

RUSF1

376

Q96GQ5
VSKMHGLSGERRRAS

RASL11A

196

Q6T310
RNTTGTGRMRHLKIV

RPL37

56

P61927
MVRLAQGLTHLGKGT

PSMD2

761

Q13200
TSMDGLKDLLRHTGR

PRAMEF22

391

A3QJZ6
NTLARRKGRHMGIGK

RPL19

66

P84098
GRGVGHSMVRKSLGR

BRPF1

1056

P55201
LGLAGGHKETRERSM

CIC

286

Q96RK0
LTRMKRHGRGEIIGI

TMEM45B

241

Q96B21
GLHMRKGVSIAVSTG

STIL

781

Q15468
GIGHRTVPMLLAKSR

VPS13A

1736

Q96RL7
NKHTALRGEMSGRLG

SPTBN2

681

O15020
SRTRKGILSQMGRHS

SRRM5

316

B3KS81
MSRLVRGGSGTKRAL

VCL

1001

P18206
TIVKRRMSHVSGGGS

NF1

811

P21359
LSIGHGGRTRMEKEL

ZBED9

316

Q6R2W3
KESTLHLVLRLRGGM

UBC

291

P0CG48
MLKFRTVHGGLRLLG

PC

1

P11498
VHTRGIGSRLLTKMG

ZGPAT

331

Q8N5A5
KRGKTMLAVRSTHGL

TYW3

136

Q6IPR3
LRGKVRFLMLVGGST

THPO

156

P40225
IKMRIGLHSGSVFAG

GUCY1A1

571

Q02108