Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	epithelial tube morphogenesis	KLHL3 CELSR1 SPINT1 LAMA5 TSC2 PLXND1 HECTD1 ITGAX NOTCH1	2.88e-06	421	59	9	GO:0060562
GeneOntologyBiologicalProcess	tissue morphogenesis	KLHL3 CELSR1 SPINT1 LAMA5 TSC2 ADAMTS5 PLXND1 FLG2 HECTD1 ITGAX NOTCH1	7.77e-06	750	59	11	GO:0048729
GeneOntologyBiologicalProcess	morphogenesis of an epithelium	KLHL3 CELSR1 SPINT1 LAMA5 TSC2 PLXND1 FLG2 HECTD1 ITGAX NOTCH1	9.20e-06	619	59	10	GO:0002009
GeneOntologyBiologicalProcess	branched-chain amino acid catabolic process	IVD ACAT1 BCKDHA	3.78e-05	23	59	3	GO:0009083
GeneOntologyBiologicalProcess	tube morphogenesis	KLHL3 CELSR1 SPINT1 LRP1 LAMA5 TSC2 PLXND1 HECTD1 ITGAX NOTCH1 CEMIP2 STAB1	6.75e-05	1125	59	12	GO:0035239
GeneOntologyBiologicalProcess	branched-chain amino acid metabolic process	IVD ACAT1 BCKDHA	7.70e-05	29	59	3	GO:0009081
GeneOntologyBiologicalProcess	aorta development	LRP1 PLXND1 HECTD1 NOTCH1	8.12e-05	80	59	4	GO:0035904
GeneOntologyBiologicalProcess	Wnt signaling pathway	CYLD DCDC2 CELSR1 NDEL1 LRP1 TSC2 DDB1 NOTCH1	1.05e-04	516	59	8	GO:0016055
GeneOntologyBiologicalProcess	tube development	KLHL3 CELSR1 SPINT1 ACAT1 LRP1 LAMA5 TSC2 PLXND1 HECTD1 ITGAX NOTCH1 CEMIP2 STAB1	1.33e-04	1402	59	13	GO:0035295
GeneOntologyBiologicalProcess	tube formation	CELSR1 SPINT1 TSC2 HECTD1 NOTCH1	1.95e-04	187	59	5	GO:0035148
GeneOntologyBiologicalProcess	morphogenesis of embryonic epithelium	CELSR1 SPINT1 LAMA5 TSC2 HECTD1	2.10e-04	190	59	5	GO:0016331
GeneOntologyBiologicalProcess	epithelium development	KLHL3 CELSR1 IL31RA SPINT1 ACAT1 LAMA5 AKAP11 TSC2 PLXND1 FLG2 HECTD1 ITGAX NOTCH1	2.12e-04	1469	59	13	GO:0060429
GeneOntologyBiologicalProcess	regulation of anatomical structure morphogenesis	CELSR1 DMRT3 NDEL1 SH3GLB1 LRP1 TSC2 PLXND1 ITGAX NOTCH1 CEMIP2 STAB1	2.31e-04	1090	59	11	GO:0022603
GeneOntologyBiologicalProcess	nephron tubule development	KLHL3 ACAT1 LAMA5 NOTCH1	2.78e-04	110	59	4	GO:0072080
GeneOntologyBiologicalProcess	neural tube development	CELSR1 SPINT1 TSC2 HECTD1 NOTCH1	2.79e-04	202	59	5	GO:0021915
GeneOntologyBiologicalProcess	neural tube closure	CELSR1 SPINT1 TSC2 HECTD1	3.08e-04	113	59	4	GO:0001843
GeneOntologyBiologicalProcess	tube closure	CELSR1 SPINT1 TSC2 HECTD1	3.19e-04	114	59	4	GO:0060606
GeneOntologyBiologicalProcess	renal tubule development	KLHL3 ACAT1 LAMA5 NOTCH1	3.41e-04	116	59	4	GO:0061326
GeneOntologyBiologicalProcess	positive regulation of cell development	CYLD NDEL1 SH3GLB1 SPINT1 LRP1 AKAP11 PLXND1 NOTCH1	3.43e-04	614	59	8	GO:0010720
GeneOntologyBiologicalProcess	amino acid catabolic process	IVD ACAT1 AHCY BCKDHA	3.52e-04	117	59	4	GO:0009063
GeneOntologyBiologicalProcess	distal tubule development	KLHL3 NOTCH1	3.57e-04	10	59	2	GO:0072017
GeneOntologyBiologicalProcess	regulation of nervous system development	NDEL1 SH3GLB1 SPINT1 LRP1 TSC2 PLXND1 ITGAX NOTCH1	3.86e-04	625	59	8	GO:0051960
GeneOntologyBiologicalProcess	primary neural tube formation	CELSR1 SPINT1 TSC2 HECTD1	3.87e-04	120	59	4	GO:0014020
GeneOntologyBiologicalProcess	dichotomous subdivision of an epithelial terminal unit	CELSR1 PLXND1	4.35e-04	11	59	2	GO:0060600
GeneOntologyBiologicalProcess	sulfur compound catabolic process	ACAT1 AHCY SUCLA2	4.70e-04	53	59	3	GO:0044273
GeneOntologyBiologicalProcess	nephron epithelium development	KLHL3 ACAT1 LAMA5 NOTCH1	4.95e-04	128	59	4	GO:0072009
GeneOntologyBiologicalProcess	positive regulation of neurogenesis	NDEL1 SH3GLB1 SPINT1 LRP1 PLXND1 NOTCH1	5.13e-04	354	59	6	GO:0050769
GeneOntologyBiologicalProcess	morphogenesis of a branching epithelium	CELSR1 SPINT1 LAMA5 PLXND1 NOTCH1	5.69e-04	236	59	5	GO:0061138
GeneOntologyBiologicalProcess	artery development	LRP1 PLXND1 HECTD1 NOTCH1	5.71e-04	133	59	4	GO:0060840
GeneOntologyBiologicalProcess	cardiac septum development	LRP1 PLXND1 HECTD1 NOTCH1	5.88e-04	134	59	4	GO:0003279
GeneOntologyBiologicalProcess	neural tube formation	CELSR1 SPINT1 TSC2 HECTD1	5.88e-04	134	59	4	GO:0001841
GeneOntologyBiologicalProcess	regulation of neurogenesis	NDEL1 SH3GLB1 SPINT1 LRP1 TSC2 PLXND1 NOTCH1	6.45e-04	515	59	7	GO:0050767
GeneOntologyCellularComponent	tricarboxylic acid cycle heteromeric enzyme complex	BCKDHA IDH3G SUCLA2	1.69e-05	18	59	3	GO:0045239
GeneOntologyCellularComponent	mitochondrial matrix	IVD ACAT1 FASTKD1 NAXD BCKDHA IDH3G SUCLA2 YARS2	1.05e-04	523	59	8	GO:0005759
Domain	EGF	CELSR1 FCGBP LRP1 LAMA5 NOTCH1 STAB1	9.61e-05	235	59	6	SM00181
Domain	EGF_LAM_2	CELSR1 LAMA5 STAB1	1.14e-04	30	59	3	PS50027
Domain	EGF_LAM_1	CELSR1 LAMA5 STAB1	1.14e-04	30	59	3	PS01248
Domain	EGF-like_dom	CELSR1 FCGBP LRP1 LAMA5 NOTCH1 STAB1	1.32e-04	249	59	6	IPR000742
Domain	Growth_fac_rcpt_	CELSR1 LRP1 LAMA5 NOTCH1 STAB1	1.33e-04	156	59	5	IPR009030
Domain	Laminin_EGF	CELSR1 LAMA5 STAB1	1.82e-04	35	59	3	PF00053
Domain	EGF_Lam	CELSR1 LAMA5 STAB1	1.82e-04	35	59	3	SM00180
Domain	Notch_dom	PAPPA NOTCH1	2.04e-04	7	59	2	IPR000800
Domain	Notch	PAPPA NOTCH1	2.04e-04	7	59	2	PF00066
Domain	NL	PAPPA NOTCH1	2.04e-04	7	59	2	SM00004
Domain	Laminin_EGF	CELSR1 LAMA5 STAB1	2.33e-04	38	59	3	IPR002049
Domain	EGF_CA	CELSR1 LRP1 NOTCH1 STAB1	5.98e-04	122	59	4	SM00179
Domain	EGF-like_Ca-bd_dom	CELSR1 LRP1 NOTCH1 STAB1	6.35e-04	124	59	4	IPR001881
Domain	EGF	CELSR1 LRP1 NOTCH1 STAB1	6.75e-04	126	59	4	PF00008
Domain	EGF_1	CELSR1 LRP1 LAMA5 NOTCH1 STAB1	1.25e-03	255	59	5	PS00022
Domain	Cytidine_deaminase-like	APOBEC2 ATIC	1.29e-03	17	59	2	IPR016193
Domain	EGF-like_CS	CELSR1 LRP1 LAMA5 NOTCH1 STAB1	1.39e-03	261	59	5	IPR013032
Domain	-	SPINT1 SPINT3	1.45e-03	18	59	2	4.10.410.10
Domain	Prtase_inh_Kunz-CS	SPINT1 SPINT3	1.45e-03	18	59	2	IPR020901
Domain	KU	SPINT1 SPINT3	1.45e-03	18	59	2	SM00131
Domain	EGF_2	CELSR1 LRP1 LAMA5 NOTCH1 STAB1	1.48e-03	265	59	5	PS01186
Domain	BPTI_KUNITZ_2	SPINT1 SPINT3	1.62e-03	19	59	2	PS50279
Domain	Kunitz_BPTI	SPINT1 SPINT3	1.62e-03	19	59	2	PF00014
Domain	BPTI_KUNITZ_1	SPINT1 SPINT3	1.62e-03	19	59	2	PS00280
Domain	Kunitz_BPTI	SPINT1 SPINT3	2.38e-03	23	59	2	IPR002223
Domain	Galactose-bd-like	LAMA5 ZZEF1 HECTD1	3.27e-03	94	59	3	IPR008979
Domain	-	CELSR1 LAMA5 PAPPA	3.37e-03	95	59	3	2.60.120.200
Domain	ASX_HYDROXYL	CELSR1 LRP1 NOTCH1	3.90e-03	100	59	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	CELSR1 LRP1 NOTCH1	4.59e-03	106	59	3	IPR000152
Domain	LAM_G_DOMAIN	CELSR1 LAMA5	6.41e-03	38	59	2	PS50025
Domain	EGF_3	CELSR1 LRP1 NOTCH1 STAB1	6.47e-03	235	59	4	PS50026
Domain	LDLR_class-A_CS	SPINT1 LRP1	7.08e-03	40	59	2	IPR023415
Domain	Laminin_G_2	CELSR1 LAMA5	7.08e-03	40	59	2	PF02210
Domain	BTB-kelch_protein	KLHL3 KBTBD12	8.15e-03	43	59	2	IPR017096
Domain	LamG	CELSR1 LAMA5	8.52e-03	44	59	2	SM00282
Domain	Ldl_recept_a	SPINT1 LRP1	8.90e-03	45	59	2	PF00057
Domain	-	SPINT1 LRP1	9.29e-03	46	59	2	4.10.400.10
Pathway	REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM	IVD ACAT1 BCKDHA	2.71e-05	20	42	3	MM15397
Pathway	REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM	IVD ACAT1 BCKDHA	3.15e-05	21	42	3	M17694
Pathway	WP_LEUCINE_ISOLEUCINE_AND_VALINE_METABOLISM	IVD ACAT1 BCKDHA	4.77e-05	24	42	3	M45511
Pathway	REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE	ACAT1 IDH3G SUCLA2	1.26e-04	33	42	3	MM15407
Pathway	REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE	ACAT1 IDH3G SUCLA2	1.38e-04	34	42	3	M784
Pathway	KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	IVD ACAT1 BCKDHA	2.99e-04	44	42	3	M11835
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	IVD CYLD NBAS CELSR1 SH3GLB1 AHCY LRP1 AKAP11 SUCLA2 YARS2	2.59e-07	686	60	10	28380382
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CYLD SMG1 DMXL2 DCDC2 AKAP11 STAB1	2.56e-06	225	60	6	12168954
Pubmed	Leucine catabolism during the differentiation of 3T3-L1 cells. Expression of a mitochondrial enzyme system.	IVD BCKDHA	2.93e-06	2	60	2	6304077
Pubmed	Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.	LRP1 ADAMTS5	2.93e-06	2	60	2	28306378
Pubmed	LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.	LRP1 ADAMTS5	2.93e-06	2	60	2	23064555
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	IVD NBAS ACAT1 FASTKD1 AKAP11 BCKDHA TSC2 FLG2 SUCLA2 ZZEF1 DDB1 YARS2	7.90e-06	1496	60	12	32877691
Pubmed	Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.	LRP1 ADAMTS5	8.77e-06	3	60	2	24474687
Pubmed	B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors.	ZNF562 ZNF561	8.77e-06	3	60	2	36717582
Pubmed	MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.	LRP1 ADAMTS5	1.75e-05	4	60	2	27084377
Pubmed	Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction.	ADAMTS5 PLXND1 NOTCH1	2.34e-05	32	60	3	31434798
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	LRP1 LAMA5 PLXND1 HECTD1	2.77e-05	100	60	4	25807483
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SMG1 LAMA5 AKAP11 PLXND1 ZZEF1 CEMIP2 STAB1	3.48e-05	529	60	7	14621295
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	CELSR1 LRP1 LAMA5 TSC2 PLXND1 ZZEF1 HECTD1 DDB1 NOTCH1 CEMIP2	3.64e-05	1201	60	10	35696571
Pubmed	WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.	TSC2 DDB1	4.37e-05	6	60	2	18381890
Pubmed	The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes.	IVD ACAT1 BCKDHA IDH3G SUCLA2 YARS2	5.13e-05	382	60	6	29222160
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	FCGBP ARSL ACAT1 AHCY LAMA5 ATIC SUCLA2 DDB1 CEMIP2	5.81e-05	1016	60	9	19056867
Pubmed	DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.	ACAT1 AHCY AKAP11 TSC2	6.04e-05	122	60	4	30773093
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CYLD DMXL2 SERGEF AHCY LRP1 TSC2 ATIC HECTD1 RPH3A STAB1	6.42e-05	1285	60	10	35914814
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	DCDC2 RECQL5 AHCY LAMA5 ATIC IDH3G FLG2 SUCLA2	6.91e-05	803	60	8	36517590
Pubmed	Functional proteomics mapping of a human signaling pathway.	SMG1 SPINT1 LRP1 LAMA5 PAPPA ZZEF1 DDB1	6.99e-05	591	60	7	15231748
Pubmed	FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act in Concert to Impair Clearing of Protein Aggregates and Autophagy.	ACAT1 AHCY ATIC SUCLA2 DDB1	7.02e-05	248	60	5	32963011
Pubmed	Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.	PCNX2 SMG1 ZZEF1	1.02e-04	52	60	3	9455477
Pubmed	Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2.	CYLD DDB1	1.05e-04	9	60	2	28035050
Pubmed	microRNA-184 Induces a Commitment Switch to Epidermal Differentiation.	FLG2 NOTCH1	1.05e-04	9	60	2	29198823
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	IVD ACAT1 LRP1 BCKDHA ATIC IDH3G SUCLA2 YARS2	1.10e-04	859	60	8	31536960
Pubmed	Zinc transporter Slc39a8 is essential for cardiac ventricular compaction.	ADAMTS5 NOTCH1	1.59e-04	11	60	2	29337306
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	FASTKD1 NAXD LRP1 LAMA5 BCKDHA ADAMTS5 IDH3G SUCLA2 DDB1 YARS2	1.74e-04	1451	60	10	30550785
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	DMRT3 NDEL1 SPINT1 DDB1 NOTCH1	1.90e-04	307	60	5	37499664
Pubmed	Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.	IVD ACAT1 SUCLA2 RPH3A	1.98e-04	166	60	4	27160897
Pubmed	Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development.	CELSR1 LAMA5	2.26e-04	13	60	2	27789626
Pubmed	Membrane-type MMPs are indispensable for placental labyrinth formation and development.	SPINT1 LAMA5	2.63e-04	14	60	2	20858856
Pubmed	A multi-resource data integration approach: identification of candidate genes regulating cell proliferation during neocortical development.	CELSR1 NOTCH1	2.63e-04	14	60	2	25191221
Pubmed	Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.	KLHL3 DCDC2 HECTD1	3.14e-04	76	60	3	10574461
Pubmed	ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.	LAMA5 ADAMTS5	3.46e-04	16	60	2	30579834
Pubmed	A cluster of cholinergic premotor interneurons modulates mouse locomotor activity.	DMRT3 PAPPA	3.91e-04	17	60	2	20005822
Pubmed	Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth.	HECTD1 DDB1	3.91e-04	17	60	2	30686098
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	AHCY LAMA5 TSC2 DDB1 NOTCH1 STAB1	4.07e-04	560	60	6	21653829
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	IVD ACAT1 NAXD BCKDHA ATIC IDH3G SUCLA2 YARS2	4.20e-04	1047	60	8	18614015
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	NBAS ACAT1 AHCY ZNF561 ATIC ZZEF1 DDB1	4.68e-04	807	60	7	30575818
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PCNX2 CELSR1 LAMA5 TSC2 PLXND1 ZZEF1 HECTD1 NOTCH1	5.99e-04	1105	60	8	35748872
Pubmed	Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.	ACAT1 AHCY	6.02e-04	21	60	2	9616220
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	ACAT1 AHCY LRP1 LAMA5 FLG2 CEMIP2	6.54e-04	613	60	6	22268729
Pubmed	Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development.	PAPPA PLXND1	6.61e-04	22	60	2	36549270
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	IVD ACAT1 FASTKD1 NAXD BCKDHA IDH3G SUCLA2 YARS2	7.17e-04	1136	60	8	34800366
Pubmed	Primary cilia in murine palatal rugae development.	CELSR1 NOTCH1	7.23e-04	23	60	2	31226309
Pubmed	Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.	RECQL5 LRP1	7.88e-04	24	60	2	17452356
Pubmed	Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.	AHCY ATIC	7.88e-04	24	60	2	17937387
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	SMG1 LRP1 DUSP19 IDH3G CEMIP2	7.94e-04	420	60	5	28065597
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	SMG1 IL31RA SH3GLB1 AHCY AKAP11 ATIC IDH3G	9.49e-04	910	60	7	36736316
Pubmed	Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons.	PAPPA NOTCH1	9.99e-04	27	60	2	24496616
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	IVD ACAT1 NAXD BCKDHA ATIC SUCLA2 YARS2	1.05e-03	926	60	7	20877624
Pubmed	Genetic link between renal birth defects and congenital heart disease.	LAMA5 PLXND1	1.07e-03	28	60	2	27002738
Pubmed	Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.	ACAT1 LRP1	1.15e-03	29	60	2	20167577
Pubmed	Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors.	HECTD1 DDB1	1.23e-03	30	60	2	34017080
Pubmed	Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening.	LRP1 NOTCH1	1.32e-03	31	60	2	32546759
Pubmed	ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.	LAMA5 NOTCH1	1.32e-03	31	60	2	22274697
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	CYLD LAMA5 HECTD1 ZRANB3 YARS2	1.45e-03	481	60	5	28190767
Pubmed	Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.	DMXL2 ACAT1	1.49e-03	33	60	2	26025364
Pubmed	Mitochondrial Raf1 Regulates Glutamine Catabolism.	ACAT1 AHCY ATIC CEMIP2	1.56e-03	288	60	4	38496616
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	KLHL3 DMXL2 DNAH10 AHCY LRP1 PLXND1	1.60e-03	730	60	6	34857952
Coexpression	GSE369_PRE_VS_POST_IL6_INJECTION_SOCS3_KO_LIVER_DN	FCGBP TSC2 PLXND1 ZZEF1 DDB1 STAB1	5.89e-06	200	59	6	M5977
Coexpression	GAO_LARGE_INTESTINE_24W_C6_SECRETORY_PROGENITOR	PLXND1 ITGAX STAB1	1.62e-05	22	59	3	M39156
ToppCell	facs-Trachea-3m-Epithelial-airway_epithelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CELSR1 FCGBP DMRT3 SPINT1 LAMA5	4.78e-06	186	59	5	37b93ebd64ebbd08193a746e5bc9b350c2570733
ToppCell	facs-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CELSR1 FCGBP DMRT3 SPINT1 LAMA5	5.04e-06	188	59	5	8ffb5394f7b00ea483a5fe4df894d22fda935e5c
ToppCell	facs-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_trachea\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CELSR1 FCGBP DMRT3 SPINT1 LAMA5	5.04e-06	188	59	5	137ed9958044fab7a13648affb469585d1c48cf6
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 LRP1 PLXND1 ITGAX STAB1	5.72e-06	193	59	5	1db487e5f81849740d57cc3e2b5739e8f7581efb
ToppCell	myeloid-Monocyte-CD14+_Monocyte\|myeloid / Lineage, cell class and subclass	DMXL2 LRP1 RPH3A NOTCH1 STAB1	6.01e-06	195	59	5	15ba9c5f6ecb6ae2c603e6b036eb92b00b46f13f
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 PLXND1 NOTCH1 CEMIP2 STAB1	6.17e-06	196	59	5	e386526332138e636aef2542c11316347a45689c
ToppCell	NS-moderate-d_07-13-Myeloid-Non-resident_Macrophage\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DMXL2 LRP1 PLXND1 ITGAX STAB1	6.32e-06	197	59	5	774a5053f43ac7d614c127ae7363d32a3a194f63
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 LRP1 PLXND1 ITGAX STAB1	6.48e-06	198	59	5	a77f3440d7fb6a50066abc7e9ad59e83798ef13d
ToppCell	Caecum-(6)_Macrophage-(61)_LYVE1_Macrophage\|Caecum / shred on region, Cell_type, and subtype	DMXL2 FCGBP LRP1 ITGAX STAB1	6.48e-06	198	59	5	e684c3934c163aef4d284b69435832d2c9614f2a
ToppCell	Caecum-Macrophage-LYVE1_Macrophage\|Caecum / Region, Cell class and subclass	DMXL2 FCGBP LRP1 ITGAX STAB1	6.48e-06	198	59	5	a92c0cacb775aca6bbb302bd9e22c081a112a44d
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 LRP1 PLXND1 ITGAX STAB1	6.48e-06	198	59	5	d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCell	COVID-19-lung\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DMXL2 LRP1 ITGAX CEMIP2 STAB1	6.64e-06	199	59	5	155b03b859157013e9142e9248551369127d9204
ToppCell	Caecum-(4)_Monocyte-(40)_Monocyte\|Caecum / shred on region, Cell_type, and subtype	DMXL2 LRP1 ITGAX RPH3A STAB1	6.80e-06	200	59	5	b078058efc51f0ff4d92123b712933b32824c655
ToppCell	Caecum-(4)_Monocyte\|Caecum / shred on region, Cell_type, and subtype	DMXL2 LRP1 ITGAX RPH3A STAB1	6.80e-06	200	59	5	6bfd6ab395e09087aeedc9a7c9ada1b4b8a26194
ToppCell	Caecum-Monocyte\|Caecum / Region, Cell class and subclass	DMXL2 LRP1 ITGAX RPH3A STAB1	6.80e-06	200	59	5	9e8d38d024a315512521b349e8ac7caa56219daf
ToppCell	COVID-19-Myeloid-MoAM2,_CCL18\|Myeloid / Condition, Lineage and Cell class	LRP1 PLXND1 ITGAX CEMIP2 STAB1	6.80e-06	200	59	5	a60346c5ea7a3dae1ad3c5dc6c6eca65b64c6888
ToppCell	COVID-19-Myeloid-MoAM2,_CCL18\|COVID-19 / Condition, Lineage and Cell class	DMXL2 LRP1 PLXND1 ITGAX STAB1	6.80e-06	200	59	5	b0a50622d00335843efad86bc56a1e910019984b
ToppCell	Caecum-Monocyte-Monocyte\|Caecum / Region, Cell class and subclass	DMXL2 LRP1 ITGAX RPH3A STAB1	6.80e-06	200	59	5	d33619b6c721eae3ebe50fba6b9d31fa99f2248f
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Intermediate_Fibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	DCDC2 DNAH10 LRP1 FLG2	3.29e-05	137	59	4	dd5364a1002650d21e0c83d8c701b5f7b09d1c19
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DCDC2 RECQL5 PAPPA ADAMTS5	6.02e-05	160	59	4	7064af50fc10e3ea03badf415306222b74db0f95
ToppCell	367C-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SCRN3 FASTKD1 ITGAX STAB1	7.27e-05	168	59	4	80233a13135fd159f5764336a1fe67fba237776b
ToppCell	facs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL3 NOTCH1 CEMIP2 STAB1	7.27e-05	168	59	4	06dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCell	facs-Heart-RA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL3 NOTCH1 CEMIP2 STAB1	7.27e-05	168	59	4	1002f058a340763e3d8de0bd1f0547a903526ec6
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	DMXL2 LRP1 PLXND1 STAB1	7.61e-05	170	59	4	9ac1ef57f14418a5dd2aa16861c3df698c28f5ed
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FCGBP LRP1 PLXND1 STAB1	8.90e-05	177	59	4	382f0d6bbff01e84b0c7840e74ac865864e6da89
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DMXL2 PLXND1 ITGAX STAB1	8.90e-05	177	59	4	f28243b51be104cb3adcde63f03fc2206ed3121e
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	SMG1 NBAS ZRANB3 CEMIP2	8.90e-05	177	59	4	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL3 LAMA5 CEMIP2 STAB1	9.29e-05	179	59	4	a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages\|lymph-node_spleen / Manually curated celltypes from each tissue	DMXL2 LRP1 ITGAX STAB1	9.50e-05	180	59	4	7be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCell	droplet-Liver-Npc-21m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHGB2 PLXND1 CEMIP2 STAB1	9.91e-05	182	59	4	dc55de945c6f78f32eb3a1b3520835eb8417e068
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHGB2 PLXND1 CEMIP2 STAB1	9.91e-05	182	59	4	010a7364da46101cb5068891fd7bc712ea8f13bd
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHGB2 PLXND1 CEMIP2 STAB1	9.91e-05	182	59	4	b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCell	Basal\|World / shred by cell class for mouse tongue	CELSR1 LAMA5 PAPPA ATIC	1.01e-04	183	59	4	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TMEM50A NAXD PLXND1 CEMIP2	1.01e-04	183	59	4	90c66ffd2c1f87c91f9a9886e28aeec542f9df85
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 NOTCH1 CEMIP2 STAB1	1.01e-04	183	59	4	b0b5a41f1a40f9c946d0dc8b67eaccdd9f9b73a5
ToppCell	droplet-Lung-21m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DMXL2 SPINT1 LRP1 ITGAX	1.03e-04	184	59	4	15ea746c77785120f69f9ab370fb7eb9b70692f8
ToppCell	droplet-Lung-21m-Hematologic-myeloid-alveolar_macrophage\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DMXL2 SPINT1 LRP1 ITGAX	1.03e-04	184	59	4	bd5e8fc453a6393b8778734a2c3c2f1281769bcd
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALKBH8 PLXND1 CEMIP2 STAB1	1.06e-04	185	59	4	742350093d90f96735dc73e3360cdd749bae63fd
ToppCell	droplet-Heart-nan-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NOTCH1 CEMIP2 STAB1	1.06e-04	185	59	4	a32d5cb596ebac80eb1ac301055e65d420879ec8
ToppCell	facs-Heart-LA-24m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 NOTCH1 CEMIP2 STAB1	1.10e-04	187	59	4	d9943e65eedab73d141eae524e2411653a751705
ToppCell	facs-Heart-LA-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 NOTCH1 CEMIP2 STAB1	1.10e-04	187	59	4	7b13c3b67d66f3afb410141d5471c9e78a4d8623
ToppCell	facs-Trachea-nan-3m-Epithelial-basal_epithelial_cell_of_tracheobronchial_tree\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 DMRT3 SPINT1 LAMA5	1.10e-04	187	59	4	fe9fc21192ede2eea61f419d20ccda254569d0a6
ToppCell	normal_Lymph_Node-Myeloid_cells-mo-Mac\|normal_Lymph_Node / Location, Cell class and cell subclass	DMXL2 LRP1 ITGAX STAB1	1.12e-04	188	59	4	e83de94a9b47a6a90e98face887eae031a322af6
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic\|GI_large-bowel / Manually curated celltypes from each tissue	DMXL2 FCGBP LRP1 STAB1	1.12e-04	188	59	4	d0045fdda757d191dabc7853f6a6e99c0e97d93d
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic-Classical_monocytes\|GI_large-bowel / Manually curated celltypes from each tissue	DMXL2 FCGBP LRP1 STAB1	1.12e-04	188	59	4	0bcf04aa47738f43c1a87dae5dc487738ee86f8c
ToppCell	wk_15-18-Epithelial-Distal_epithelial-epi-tip_early\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	DCDC2 ARSL SPINT1 AHCY	1.12e-04	188	59	4	eefd2930833d216efbd72f67541bb2d9e7d47f3b
ToppCell	3'_v3-GI_small-bowel-Myeloid_Monocytic-Classical_monocytes\|GI_small-bowel / Manually curated celltypes from each tissue	DMXL2 LRP1 ITGAX RPH3A	1.15e-04	189	59	4	74a5e61cd820f2495dde40e766c771a31d8c4e7d
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 PLXND1 CEMIP2 STAB1	1.15e-04	189	59	4	1137583e21d874c201c20581ba1995e2bfa3de59
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 PLXND1 CEMIP2 STAB1	1.17e-04	190	59	4	7068754c29f63a331e2b6c54715f3b26f37ad32b
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_monocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 LRP1 ITGAX STAB1	1.17e-04	190	59	4	00ef6ec71353e42260c0d807d7da65b63154c288
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 LRP1 ITGAX STAB1	1.17e-04	190	59	4	18c020ca9a23399214133ec255ab870e0060f2e1
ToppCell	facs-Heart-LA-24m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NOTCH1 CEMIP2 STAB1	1.17e-04	190	59	4	911b93c4c828ef2d867b91a5eced2dc12a1baf27
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 NOTCH1 CEMIP2 STAB1	1.17e-04	190	59	4	38a815abf0ac5cac6071737cadc54a514f62d37d
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 NOTCH1 CEMIP2 STAB1	1.17e-04	190	59	4	bb1476b44dd49e1dd52a636a91c4600b6d4fbe2e
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 NOTCH1 CEMIP2 STAB1	1.17e-04	190	59	4	d180205c70b5ca9bc5a01a2e6cb42fcebc7f630d
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DCDC2 RECQL5 PAPPA ADAMTS5	1.17e-04	190	59	4	078f4be52fa4cc8dd9c8d7a2b6d9631c3d902285
ToppCell	Control-Myeloid\|Control / group, cell type (main and fine annotations)	DMXL2 LRP1 ITGAX STAB1	1.19e-04	191	59	4	9c4acc5f3c2f9c0c5520863bb22f391774372347
ToppCell	Myeloid-Myeloid-B_(Activated_Macrophage)\|Myeloid / shred on cell class and cell subclass (v4)	DMXL2 LRP1 ITGAX DDB1	1.19e-04	191	59	4	7bf125249af1e8bb138ed4d999fdd74b03ab2447
ToppCell	NS-critical-d_0-4\|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DMXL2 LRP1 PLXND1 STAB1	1.19e-04	191	59	4	769942a6a31c13c583dc38e8a762df2f5c06c2fb
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRP1 PAPPA ISLR ADAMTS5	1.19e-04	191	59	4	9f478f36a0b895e607e3bb77fa0f9f03cc0f33fc
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NOTCH1 CEMIP2 STAB1	1.22e-04	192	59	4	2bfac6b3956265205ca47d06888851ed68b65999
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NOTCH1 CEMIP2 STAB1	1.22e-04	192	59	4	5890076929598e88fe9d59a4e4e858b446746ce9
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NOTCH1 CEMIP2 STAB1	1.22e-04	192	59	4	d525f7f088a53110912600a7c9f6d33b9270d534
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 LRP1 ITGAX STAB1	1.24e-04	193	59	4	5f732598cdb6f3bd519f044a9cc553bd2e8b1052
ToppCell	(4)_Endothelial_cells\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	ADAMTS5 PLXND1 NOTCH1 STAB1	1.24e-04	193	59	4	ae6ba13d4d9f2a700887cdda2790c32007b29ac8
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NOTCH1 CEMIP2 STAB1	1.24e-04	193	59	4	826b8dd801298b3e0cd76232feae5a14026b8806
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ISLR PLXND1 NOTCH1 STAB1	1.24e-04	193	59	4	daefbfd3a3dd1351fbe94b9abfd807db44d56c24
ToppCell	Leuk-UTI-Myeloid-CD14_Mono\|Leuk-UTI / Disease, Lineage and Cell Type	DMXL2 LRP1 PLXND1 STAB1	1.24e-04	193	59	4	d1eac8627d00629ed2e81d3b86778007304efcb7
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NOTCH1 CEMIP2 STAB1	1.24e-04	193	59	4	4a8c97ff2dffc5c06351d1cb107e21e58250aa55
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NOTCH1 CEMIP2 STAB1	1.24e-04	193	59	4	87d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)\|Adult / Lineage, Cell type, age group and donor	DMXL2 LRP1 PLXND1 STAB1	1.24e-04	193	59	4	31c0978ba78c9516d498aec0798902e57555e557
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NOTCH1 CEMIP2 STAB1	1.24e-04	193	59	4	d5f6d6e2c36d4e80af4d39cdfc0b18df295a587b
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NOTCH1 CEMIP2 STAB1	1.24e-04	193	59	4	d485634c564b268e344b6a2863c26f6adaec9e38
ToppCell	facs-Liver-Non-hepatocytes-3m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NOTCH1 CEMIP2 STAB1	1.24e-04	193	59	4	8084fa0ce61f1f4a728423b6b81df04eaa5af5b6
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMXL2 LRP1 CEMIP2 STAB1	1.24e-04	193	59	4	4fb020f11fd7aff06952bfeaabc79b2c7b8873f6
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NOTCH1 CEMIP2 STAB1	1.27e-04	194	59	4	c8b9551b93a5aed62154b487db90130604a6125c
ToppCell	Control-Classical_Monocyte\|Control / Disease condition and Cell class	DMXL2 LRP1 PLXND1 STAB1	1.27e-04	194	59	4	9e33e1b54b4114f9e6981819834bb796ed7192b5
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D231\|Adult / Lineage, Cell type, age group and donor	DMXL2 PLXND1 ITGAX STAB1	1.27e-04	194	59	4	800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCell	COVID-19-Heart-Fib_2\|Heart / Disease (COVID-19 only), tissue and cell type	PCNX2 LRP1 PAPPA ADAMTS5	1.27e-04	194	59	4	d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DMXL2 LRP1 CEMIP2 STAB1	1.27e-04	194	59	4	885355ebe98e974f841cc59dce3b5228c642c5d0
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 LRP1 ITGAX STAB1	1.27e-04	194	59	4	a94f9f7179a5733e3c378ff8b337e288785433a1
ToppCell	(4)_Endothelial_cells-(42)_EC-sinusoidal\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	ADAMTS5 PLXND1 NOTCH1 STAB1	1.27e-04	194	59	4	4428b472c2042f88eae028b1770767512a515b75
ToppCell	RA-08._Macrophage\|RA / Chamber and Cluster_Paper	DMXL2 ITGAX CEMIP2 STAB1	1.27e-04	194	59	4	ac26e5c71d5069622de72fa25a9c920887ac2c19
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NOTCH1 CEMIP2 STAB1	1.29e-04	195	59	4	12ba6d95e42d06b1991b011043c0e3370a7b4131
ToppCell	COVID-19-lung-Macrophage_CD163hi_MERTKhi\|lung / Disease (COVID-19 only), tissue and cell type	DMXL2 LRP1 ITGAX STAB1	1.29e-04	195	59	4	148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 LRP1 ITGAX STAB1	1.29e-04	195	59	4	580ed65b4152483b642a7e7dbdf00d03588c46f6
ToppCell	facs-Heart-RA-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NOTCH1 CEMIP2 STAB1	1.29e-04	195	59	4	30c75761079fa1e1a3b84d23c88a222f459d5ce5
ToppCell	facs-Trachea\|facs / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LSMEM1 LRP1 ISLR ADAMTS5	1.32e-04	196	59	4	8209f2b0f7efebaaf81d642d18a1aee8a9a8dcf6
ToppCell	COVID-19-lung-Macrophage_metabolically_active\|lung / Disease (COVID-19 only), tissue and cell type	DMXL2 LRP1 ITGAX STAB1	1.32e-04	196	59	4	a753d76d764c181eecb0e17a794a2e7d0ff70136
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_monocytic\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 LRP1 ITGAX STAB1	1.32e-04	196	59	4	f943519bff51c3094776fd45889dadf9062c8379
ToppCell	facs-Trachea\|facs / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LSMEM1 LRP1 ISLR ADAMTS5	1.32e-04	196	59	4	34020d6553309daa269dff05de0a8567211ea4d2
ToppCell	COVID-19-lung-Macrophage_metabolically_active\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DMXL2 LRP1 ITGAX STAB1	1.32e-04	196	59	4	1b7928f4eee94d4bb6ea410bab68a471dba12979
ToppCell	COVID-19-lung-Macrophage_CD163hi_MERTKhi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DMXL2 LRP1 ITGAX STAB1	1.32e-04	196	59	4	7026c1fc33425e5476063d17c79e4b79356a9e01
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NOTCH1 CEMIP2 STAB1	1.34e-04	197	59	4	deefb492b5f0e6014144bd465c4a6ae4206e8739
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	IVD LRP1 PAPPA ISLR	1.34e-04	197	59	4	fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell	(6)_Macrophage\|World / shred on Cell_type and subtype	DMXL2 LRP1 ITGAX STAB1	1.34e-04	197	59	4	010b275d4da4a896175ad7fbaa96d1dc11a0b744
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NOTCH1 CEMIP2 STAB1	1.34e-04	197	59	4	a6aaa6faea348291023f0bc4b0f83fbc67d91da6
ToppCell	nucseq-Immune-Immune_Myeloid-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DMXL2 PLXND1 ITGAX STAB1	1.34e-04	197	59	4	6f41c8f815851968849428ec92c16745bd01a3fb
ToppCell	myeloid-Monocyte\|myeloid / Lineage, cell class and subclass	DMXL2 LRP1 NOTCH1 STAB1	1.34e-04	197	59	4	6acf059cee6ba6bdeacc089b090d72336790972a
ToppCell	nucseq-Immune-Immune_Myeloid-IM-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DMXL2 PLXND1 ITGAX STAB1	1.34e-04	197	59	4	304044ace926943b8eb588f686ecbe5d1689a809
Drug	Diflorasone Diacetate [33564-31-7]; Down 200; 8uM; MCF7; HT_HG-U133A	CYLD ZNF93 DMXL2 RECQL5 IDH3G ZZEF1	1.16e-05	196	59	6	2798_DN
Drug	Saquinavir mesylate [149845-06-7]; Up 200; 5.2uM; HL60; HT_HG-U133A	PCNX2 CYLD KLHL3 ZNF93 LRP1 ZZEF1	1.23e-05	198	59	6	6127_UP
Drug	Zoxazolamine [61-80-3]; Up 200; 23.8uM; PC3; HT_HG-U133A	PCNX2 RECQL5 LRP1 ADAMTS5 PLXND1 RPH3A	1.23e-05	198	59	6	6290_UP
Disease	Disorder of organic acid metabolism	IVD ACAT1 BCKDHA	5.76e-06	18	58	3	cv:C1263739
Disease	Other License Status	KLHL3 TSC2	2.27e-05	4	58	2	C3889261
Disease	susceptibility to scarlet fever measurement	CELSR1 ACAT1 SUCLA2	5.13e-04	79	58	3	EFO_0008409
Disease	Hodgkins lymphoma	FCGBP ISLR STAB1	5.72e-04	82	58	3	EFO_0000183
Disease	visceral adipose tissue measurement, body mass index	NBAS DNAH10 SUCLA2	6.79e-04	87	58	3	EFO_0004340, EFO_0004765
Disease	obesity (implicated_via_orthology)	DNAH10 ACAT1 PLXND1 NOTCH1	8.55e-04	215	58	4	DOID:9970 (implicated_via_orthology)
Disease	arteriosclerosis (is_marker_for)	ACAT1 PAPPA	1.49e-03	29	58	2	DOID:2349 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DDLGIGDIGCYGNNT	ARSL	46	P51690
SGSIVADIGCGNGKY	ALKBH8	406	Q96BT7
ADIGCGNGKYLGINK	ALKBH8	411	Q96BT7
KGLVQNIDQLYSGGG	ADAMTS5	71	Q9UNA0
SLNGYGCGDNVVQAV	AKAP11	1526	Q9UKA4
SQGNKCGVADGEGFL	DMXL2	2816	Q8TDJ6
GKDIGNYSCAAQGTQ	CELSR1	1571	Q9NYQ6
CYVVEAQGKGGQVQA	APOBEC2	71	Q9Y235
AQGKGGQVQASRGYL	APOBEC2	76	Q9Y235
KITAANQTGGLYQCG	ITGAX	56	P20702
SYIQSGCQSGIKGGQ	FLG2	311	Q5D862
CKNGGACVDGVNTYN	NOTCH1	266	P46531
TGQENNLGGEKNGYV	IL31RA	626	Q8NI17
GYSLRSGQQACEGVG	LRP1	1876	Q07954
GGGCCKEQELTYELQ	KIAA2026	66	Q5HYC2
GKGCYTVDNEVQPSG	ISLR	366	O14498
QCSGYGSGEGGNAIK	PCNX2	466	A6NKB5
ESYIQLGLQCAGGAG	PLXND1	336	Q9Y4D7
SGENGEVYCQVLGNA	PCDHGB2	376	Q9Y5G2
GQDGRIGVVGGCQEY	NAXD	71	Q8IW45
QSLDGTYQGGGVCID	LAMA5	381	O15230
YCGDGIIQKDQGEQC	PAPPA	946	Q13219
LDGIQCFGGNGYIND	IVD	376	P26440
QKCGGAYQIGTTANE	NBAS	1451	A2RRP1
LYGTVNGVCEDQLGK	HECTD1	1236	Q9ULT8
YGNIVNNVCAGLVGG	IDH3G	276	P51553
EEGGYAVQKNGGNPE	DMRT3	201	Q9NQL9
CKEQGGQGVCLPNYE	FCGBP	1656	Q9Y6R7
CQQYNKGIGGMDGTQ	FASTKD1	686	Q53R41
QGGQNKYVGTGGIDQ	CEMIP2	841	Q9UHN6
QDTGSCGIQEDGKLY	LSMEM1	6	Q8N8F7
NGLLYVVGGDDGSCN	KLHL3	536	Q9UH77
GRGQGFTDGVYQGKQ	CYLD	171	Q9NQC7
NSLGIGDYITGCKQA	DNAH10	751	Q8IVF4
AVVAGYGDVGKGCAQ	AHCY	216	P23526
KLDQIQSGGNYVAGG	DCDC2	76	Q9UHG0
QSGGNYVAGGQEAFK	DCDC2	81	Q9UHG0
GQGQLVTCSGAFKEG	DDB1	371	Q16531
AQCYGNISDLGKGRQ	BCKDHA	176	P12694
NSEIYVLGGIGCVGQ	KBTBD12	491	Q3ZCT8
DGGDLFVCGLNKDGQ	SERGEF	66	Q9UGK8
KSNDYIGGCQLGISA	RPH3A	646	Q9Y2J0
GQVRGDSYSEGCLGQ	TMEM50A	76	O95807
YGCRVQLGGSDQLGN	YARS2	236	Q9Y2Z4
VDLLEKYGQGGNCTE	SCRN3	131	Q0VDG4
AVYGGGGQQAESKQS	SMG1	2436	Q96Q15
IQNDEKGGYSVNGGS	nan	76	Q6P435
GTAYGNALIKCGETQ	SH3GLB1	111	Q9Y371
ALKQGEYGLASICNG	ACAT1	401	P24752
KANLNYIGLDGNIGC	SUCLA2	306	Q9P2R7
GQEADKGLSGCGIVY	RECQL5	251	O94762
NGGNTSEGNCYGKDT	ZNF561	141	Q8N587
DECKVHTGGYNGLNQ	ZNF93	121	P35789
AQNGGNTFEGNCYGK	ZNF562	146	Q6V9R5
NSGDYKNPGLIQDCG	SPEM3	911	A0A1B0GUW6
GGCLGNKNNYLREEE	SPINT1	281	O43278
YGGCGGNSNNFLRKE	SPINT3	66	P49223
YGKGNCSDGIQGNGA	STAB1	741	Q9NY15
NEDLGYCSGGGNNKI	VN1R4	161	Q7Z5H5
NSVCYAKNGQVIGIG	ATIC	431	P31939
YQLVQKGGGQECGDS	ZZEF1	2301	O43149
KVYLGGLDVCGEDGQ	TSC2	1591	P49815
YGGGGQCSLDNLQTL	ZRANB3	1026	Q5FWF4
GGGCGYVQDLSSDLQ	DUSP19	51	Q8WTR2
YISGNVNCGVLNGNG	NDEL1	286	Q9GZM8