Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR4A47 OR4C45 OR2T1 OR2T10 OR2T34 OR2T11 OR2T3 OR2T6 OR6C76 OR4C5

6.60e-0543110110GO:0004984
GeneOntologyMolecularFunctionzinc ion binding

USP49 NR2C1 RCHY1 SIVA1 RPS27 CBLB APIP USP51 TADA2B SEC24B CDADC1 KDM2A TADA2A DTX2

1.55e-0489110114GO:0008270
GeneOntologyMolecularFunctiontransition metal ion binding

USP49 NR2C1 RCHY1 SIVA1 RPS27 ADNP CBLB ADCY2 APIP USP51 TADA2B SEC24B CDADC1 KDM2A TADA2A DTX2

3.00e-04118910116GO:0046914
DomainAda2/TADA2

TADA2B TADA2A

2.78e-052992IPR016827
DomainRibosomal_S27e

RPS27 RPS27L

2.78e-052992IPR000592
DomainRibosomal_S27e_Zn-bd_dom

RPS27 RPS27L

2.78e-052992IPR023407
DomainRibosomal_S27e

RPS27 RPS27L

2.78e-052992PF01667
Domain-

RPS27 RPS27L

2.78e-0529922.20.25.100
DomainRibosomal_S27e

RPS27 RPS27L

2.78e-052992PD004466
DomainRIBOSOMAL_S27E

RPS27 RPS27L

2.78e-052992PS01168
DomainOlfact_rcpt

OR4A47 OR2T1 OR2T10 OR2T34 OR2T11 OR2T3 OR2T6 OR6C76 OR4C5

2.41e-04393999IPR000725
DomainEGF

LAMA2 TEK SVEP1 EGF TIE1 ASTN1 LTBP2

2.55e-04235997SM00181
DomainEGF_extracell

TEK SVEP1 TIE1 LTBP2

2.88e-0460994IPR013111
DomainEGF_2

TEK SVEP1 TIE1 LTBP2

2.88e-0460994PF07974
DomainEGF-like_dom

LAMA2 TEK SVEP1 EGF TIE1 ASTN1 LTBP2

3.61e-04249997IPR000742
DomainAdcy_conserved_dom

ADCY2 ADCY7

4.11e-046992IPR009398
DomainDUF1053

ADCY2 ADCY7

4.11e-046992PF06327
DomainEGF_1

LAMA2 TEK SVEP1 EGF TIE1 ASTN1 LTBP2

4.17e-04255997PS00022
DomainEGF-like_CS

LAMA2 TEK SVEP1 EGF TIE1 ASTN1 LTBP2

4.79e-04261997IPR013032
DomainEGF_2

LAMA2 TEK SVEP1 EGF TIE1 ASTN1 LTBP2

5.24e-04265997PS01186
Domain-

USP49 RCHY1 ZNF423 ZNF521 CBLB USP51 KDM2A DTX2 RNF180

6.34e-044499993.30.40.10
DomainZnf_RING/FYVE/PHD

USP49 RCHY1 ZNF423 ZNF521 CBLB USP51 KDM2A DTX2 RNF180

7.41e-04459999IPR013083
DomainPI3K_C2_dom

PIK3C3 PIK3CA

7.63e-048992IPR002420
DomainPI3K_C2

PIK3C3 PIK3CA

7.63e-048992PF00792
DomainAC_N

ADCY2 ADCY7

7.63e-048992IPR032628
DomainAdcy

ADCY2 ADCY7

7.63e-048992IPR030672
DomainPI3K_C2

PIK3C3 PIK3CA

7.63e-048992PS51547
DomainAC_N

ADCY2 ADCY7

7.63e-048992PF16214
DomainPI3K_C2

PIK3C3 PIK3CA

7.63e-048992SM00142
DomainPI3Ka

PIK3C3 PIK3CA

9.77e-049992PF00613
DomainRibosomal_zn-bd

RPS27 RPS27L

9.77e-049992IPR011332
Domain-

PIK3C3 PIK3CA

9.77e-0499921.25.40.70
DomainPI3Ka

PIK3C3 PIK3CA

9.77e-049992SM00145
DomainPIK_HELICAL

PIK3C3 PIK3CA

1.22e-0310992PS51545
DomainPI_Kinase

PIK3C3 PIK3CA

1.22e-0310992IPR015433
DomainPInositide-3_kin_accessory_dom

PIK3C3 PIK3CA

1.22e-0310992IPR001263
DomainTyrKc

TEK TIE1 FES EPHA4

1.23e-0388994SM00219
DomainTyr_kinase_cat_dom

TEK TIE1 FES EPHA4

1.23e-0388994IPR020635
DomainGrowth_fac_rcpt_

TEK SVEP1 EGF TIE1 LTBP2

1.45e-03156995IPR009030
DomainIL-1_rcpt_fam

IL1RAPL1 IL1RL1

1.48e-0311992IPR015621
Domain-

SVEP1 EGF

1.48e-03119922.40.155.10
DomainGFP-like

SVEP1 EGF

1.48e-0311992IPR023413
DomainEGF_3

TEK SVEP1 EGF TIE1 ASTN1 LTBP2

1.58e-03235996PS50026
DomainPROTEIN_KINASE_TYR

TEK TIE1 FES EPHA4

1.77e-0397994PS00109
DomainTyr_kinase_AS

TEK TIE1 FES EPHA4

1.77e-0397994IPR008266
DomainHEAT

NCAPD3 HEATR1 TBCD

2.10e-0348993PF02985
DomainZnf_UBP

USP49 USP51

2.43e-0314992IPR001607
Domainzf-UBP

USP49 USP51

2.43e-0314992PF02148
DomainZF_UBP

USP49 USP51

2.43e-0314992PS50271
DomainPI3/4_kinase_CS

PIK3C3 PIK3CA

2.79e-0315992IPR018936
Domain7tm_1

OR4A47 OR2T1 OR2T10 LTB4R2 OR2T34 OR2T11 OR2T3 OR2T6 OR6C76 OR4C5

3.14e-036779910PF00001
Domain-

PIK3C3 PIK3CA

3.18e-03169921.10.1070.11
DomainPI3Kc

PIK3C3 PIK3CA

3.18e-0316992SM00146
DomainZnf_C2H2-like

ZNF142 ZBTB38 ZNF549 ZNF423 ZNF429 ZNF521 ADNP ZNF883 AKAP8L ZNF547 ZFP91

3.26e-037969911IPR015880
DomainG_PROTEIN_RECEP_F1_1

OR4A47 OR2T1 OR2T10 LTB4R2 OR2T34 OR2T11 OR2T3 OR2T6 OR6C76 OR4C5

3.41e-036859910PS00237
DomainZnf_C2H2

ZNF142 ZBTB38 ZNF549 ZNF423 ZNF429 ZNF521 ADNP ZNF883 AKAP8L ZNF547 ZFP91

3.55e-038059911IPR007087
DomainA/G_cyclase_CS

ADCY2 ADCY7

3.59e-0317992IPR018297
DomainHEAT

NCAPD3 HEATR1 TBCD

3.61e-0358993IPR000357
DomainG_PROTEIN_RECEP_F1_2

OR4A47 OR2T1 OR2T10 LTB4R2 OR2T34 OR2T11 OR2T3 OR2T6 OR6C76 OR4C5

3.63e-036919910PS50262
DomainZnF_C2H2

ZNF142 ZBTB38 ZNF549 ZNF423 ZNF429 ZNF521 ADNP ZNF883 AKAP8L ZNF547 ZFP91

3.65e-038089911SM00355
DomainGPCR_Rhodpsn

OR4A47 OR2T1 OR2T10 LTB4R2 OR2T34 OR2T11 OR2T3 OR2T6 OR6C76 OR4C5

3.67e-036929910IPR000276
Domainzf-C2H2

ZNF142 ZBTB38 ZNF549 ZNF423 ZNF429 ZNF521 ADNP ZNF883 ZNF547 ZFP91

3.70e-036939910PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF142 ZBTB38 ZNF549 ZNF423 ZNF429 ZNF521 ADNP ZNF883 ZNF547 ZFP91

3.74e-036949910IPR013087
DomainPI3/4_kinase_cat_dom

PIK3C3 PIK3CA

4.03e-0318992IPR000403
DomainPI3_PI4_kinase

PIK3C3 PIK3CA

4.03e-0318992PF00454
DomainPI3_4_KINASE_3

PIK3C3 PIK3CA

4.03e-0318992PS50290
DomainNucleotide_cyclase

ADCY2 ADCY7

4.03e-0318992IPR029787
DomainPI3_4_KINASE_1

PIK3C3 PIK3CA

4.03e-0318992PS00915
DomainPI3_4_KINASE_2

PIK3C3 PIK3CA

4.03e-0318992PS00916
Domain-

ADCY2 ADCY7

4.03e-03189923.30.70.1230
DomainZnf_ZZ

TADA2B TADA2A

4.48e-0319992IPR000433
DomainGUANYLATE_CYCLASE_1

ADCY2 ADCY7

4.48e-0319992PS00452
DomainGuanylate_cyc

ADCY2 ADCY7

4.48e-0319992PF00211
DomainGUANYLATE_CYCLASE_2

ADCY2 ADCY7

4.48e-0319992PS50125
DomainA/G_cyclase

ADCY2 ADCY7

4.48e-0319992IPR001054
DomainCYCc

ADCY2 ADCY7

4.48e-0319992SM00044
DomainZnF_ZZ

TADA2B TADA2A

4.48e-0319992SM00291
DomainEGF

SVEP1 EGF TIE1 LTBP2

4.54e-03126994PF00008
DomainPkinase_Tyr

TEK TIE1 FES EPHA4

4.93e-03129994PF07714
DomainUSP_CS

USP49 USP51 USP32

5.19e-0366993IPR018200
PathwayREACTOME_SENSORY_PERCEPTION

PDE6B OR4A47 OR4C45 OR2T1 TWF2 OR2T10 OR2T34 OR2T11 OR2T3 OR2T6 OR6C76 SCNN1A OR4C5

4.80e-056367913M41834
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR4A47 OR4C45 OR2T1 OR2T10 OR2T34 OR2T11 OR2T3 OR2T6 OR6C76 PRKG1

6.02e-053897910M14091
Pubmed

SHIP2 (SH2 domain-containing inositol phosphatase 2) SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor.

INPPL1 CBLB EGF

4.87e-076102319880507
Pubmed

An inter-species protein-protein interaction network across vast evolutionary distance.

DPH2 CAMTA2 CBLB TRIP13 AKAP8L DENR APIP TADA2A DTX2 UPP2

1.66e-064831021027107014
Pubmed

The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis.

TEK EGF TIE1

2.90e-061010239367982
Pubmed

Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.

TEK PPP3CA TIE1 EPHA4

7.16e-0642102411439183
Pubmed

Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse.

INPPL1 PIK3CA

8.52e-062102222750293
Pubmed

E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia.

SIVA1 CBLB

8.52e-062102227773928
Pubmed

Evidence for heterotypic interaction between the receptor tyrosine kinases TIE-1 and TIE-2.

TEK TIE1

8.52e-062102210995770
Pubmed

Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells.

TEK TIE1

8.52e-06210228395828
Pubmed

Neddylation modification of ribosomal protein RPS27L or RPS27 by MDM2 or NEDP1 regulates cancer cell survival.

RPS27 RPS27L

8.52e-062102232779270
Pubmed

Localization of the angiopoietin receptors Tie-1 and Tie-2 on the primary cilia in the female reproductive organs.

TEK TIE1

8.52e-062102215893943
Pubmed

Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival.

TEK TIE1

8.52e-062102217504972
Pubmed

Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands.

TEK TIE1

8.52e-062102220227369
Pubmed

Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein.

ZNF423 ZNF521

8.52e-062102212393497
Pubmed

AIG1 is a novel Pirh2-interacting protein that activates the NFAT signaling pathway.

RCHY1 AIG1

8.52e-062102221622095
Pubmed

Tie-1: A potential target for anti-angiogenesis therapy.

TEK TIE1

8.52e-062102226489611
Pubmed

Ferulic acid ameliorates lipopolysaccharide-induced tracheal injury via cGMP/PKGII signaling pathway.

SCNN1A PRKG1

8.52e-062102234863181
Pubmed

A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription.

TADA2B TADA2A

8.52e-062102212972612
Pubmed

Reduced level of epidermal growth factor in the skeletal muscle of mice with muscular dystrophy.

LAMA2 EGF

8.52e-06210221577403
Pubmed

EphA4/Tie2 crosstalk regulates leptomeningeal collateral remodeling following ischemic stroke.

TEK EPHA4

8.52e-062102231689239
Pubmed

The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

TEK TIE1

8.52e-06210228846781
Pubmed

A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains.

TEK TIE1

8.52e-06210221312667
Pubmed

Deficiency in the p110alpha subunit of PI3K results in diminished Tie2 expression and Tie2(-/-)-like vascular defects in mice.

TEK PIK3CA

8.52e-062102215687236
Pubmed

Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis.

TEK TIE1

8.52e-062102214530387
Pubmed

Tie2 receptor expression and phosphorylation in cultured cells and mouse tissues.

TEK TIE1

8.52e-06210229108247
Pubmed

SVEP1 as a Genetic Modifier of TEK-Related Primary Congenital Glaucoma.

TEK SVEP1

8.52e-062102233027505
Pubmed

Molecular genetics of successful smoking cessation: convergent genome-wide association study results.

ZNF423 TEK ADCY2 ASTN1 PRKG1

1.25e-05101102518519826
Pubmed

Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.

TEK SVEP1 TIE1

1.33e-0516102328179430
Pubmed

Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function.

SPRY1 TEK TIE1

1.94e-0518102321483770
Pubmed

Tie1 regulates the Tie2 agonistic role of angiopoietin-2 in human lymphatic endothelial cells.

TEK TIE1

2.55e-053102222342979
Pubmed

Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems.

TEK TIE1

2.55e-053102227941161
Pubmed

Ligand-independent Tie2 dimers mediate kinase activity stimulated by high dose angiopoietin-1.

TEK TIE1

2.55e-053102223504320
Pubmed

Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2.

TEK TIE1

2.55e-053102217728252
Pubmed

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation.

TEK TIE1

2.55e-05310227596437
Pubmed

Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development.

TEK TIE1

2.55e-053102210498691
Pubmed

A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions.

TEK TIE1

2.55e-053102232822567
Pubmed

Direct transcriptional repression of Zfp423 by Zfp521 mediates a bone morphogenic protein-dependent osteoblast versus adipocyte lineage commitment switch.

ZNF423 ZNF521

2.55e-053102224891617
Pubmed

Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates.

RPS27 RPS27L

2.55e-053102237306301
Pubmed

The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells.

TEK TIE1

2.55e-053102226344773
Pubmed

ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies.

ZNF423 ZNF521

2.55e-053102226788497
Pubmed

Vascular endothelial growth factor modulates the Tie-2:Tie-1 receptor complex.

TEK TIE1

2.55e-053102211866538
Pubmed

Human urine-derived stem cell-derived exosomal miR-21-5p promotes neurogenesis to attenuate Rett syndrome via the EPha4/TEK axis.

TEK EPHA4

2.55e-053102233976355
Pubmed

Primary Congenital Glaucoma

TEK LTBP2

2.55e-053102220301314
Pubmed

A unique pattern of Tie1 expression in the developing murine lung.

TEK TIE1

2.55e-053102212554357
Pubmed

Tie1 controls angiopoietin function in vascular remodeling and inflammation.

TEK TIE1

2.55e-053102227548530
Pubmed

The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling.

TEK TIE1

2.55e-053102222235284
Pubmed

Polydom/SVEP1 binds to Tie1 and promotes migration of lymphatic endothelial cells.

SVEP1 TIE1

5.09e-054102237338522
Pubmed

Expression of VEGF receptors VEFGR-1 and VEGFR-2, angiopoietin receptors Tie-1 and Tie-2 in chorionic villi tree during early pregnancy.

TEK TIE1

5.09e-054102220164029
Pubmed

Signaling and functions of angiopoietin-1 in vascular protection.

TEK TIE1

5.09e-054102216645151
Pubmed

TEIF associated centrosome activity is regulated by EGF/PI3K/Akt signaling.

EGF PIK3CA

5.09e-054102224769208
Pubmed

Somatic mutation spectrum of a Chinese cohort of pediatrics with vascular malformations.

TEK PIK3CA

5.09e-054102237658401
Pubmed

Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator.

RPS27 RPS27L

5.09e-054102221170087
Pubmed

ADP-ribosylation factor 1 controls the activation of the phosphatidylinositol 3-kinase pathway to regulate epidermal growth factor-dependent growth and migration of breast cancer cells.

EGF PIK3CA

5.09e-054102218990689
Pubmed

The distribution of angiopoietin-1, angiopoietin-2 and their receptors tie-1 and tie-2 in the very early human placenta.

TEK TIE1

5.09e-054102218675456
Pubmed

A combinatorial role of angiopoietin-1 and orphan receptor TIE1 pathways in establishing vascular polarity during angiogenesis.

TEK TIE1

5.09e-054102211172728
Pubmed

TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth.

TEK TIE1

8.47e-05510229683559
Pubmed

Dysplastic spondylolysis is caused by mutations in the diastrophic dysplasia sulfate transporter gene.

GDF5 SLC26A2

8.47e-055102226077908
Pubmed

Che1/AATF interacts with subunits of the histone acetyltransferase core module of SAGA complexes.

TADA2B TADA2A

8.47e-055102229232376
Pubmed

Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

CBLB PIK3CA

8.47e-055102211526404
Pubmed

Expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumor, leiomyoma and schwannoma.

TEK TIE1

8.47e-055102217724803
Pubmed

Vascularization of the mouse embryo: a study of flk-1, tek, tie, and vascular endothelial growth factor expression during development.

TEK TIE1

8.47e-05510227647376
Pubmed

Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells.

ZNF423 ZNF521

8.47e-055102214630787
Pubmed

The protein tyrosine kinase family of the human genome.

TEK TIE1 FES EPHA4

1.07e-0483102411114734
Pubmed

Genetic variations in humans associated with differences in the course of hepatitis C.

EGF LTBP2 IL1RL1

1.14e-0432102315063762
Pubmed

Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells.

TEK TIE1

1.27e-046102218439490
Pubmed

Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development.

TEK TIE1

1.27e-046102216189264
Pubmed

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium.

TEK TIE1

1.27e-04610227596436
Pubmed

Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation.

TEK TIE1

1.27e-046102210446940
Pubmed

Mouse uroporphyrinogen decarboxylase: cDNA cloning, expression, and mapping.

TEK TIE1

1.27e-04610228661721
Pubmed

A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling.

EGF PIK3CA

1.27e-046102210648629
Pubmed

Recruitment of Sprouty1 to immune synapse regulates T cell receptor signaling.

SPRY1 CBLB

1.27e-046102219915061
Pubmed

hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl.

SPRY1 EGF

1.27e-046102212593796
Pubmed

Tlag2, an N-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4.

TEK TIE1

1.77e-047102211813303
Pubmed

Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium.

TEK TIE1

1.77e-047102211344305
Pubmed

Early induction of angiogenetic signals in gliomas of GFAP-v-src transgenic mice.

TEK TIE1

1.77e-047102210027415
Pubmed

Common variants in the GDF5-UQCC region are associated with variation in human height.

GDF5 ZBTB38

1.77e-047102218193045
Pubmed

Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs.

ADCY2 ADCY7

1.77e-047102238109525
Pubmed

Net-targeted mutant mice develop a vascular phenotype and up-regulate egr-1.

TEK TIE1

1.77e-047102211566878
Pubmed

EphA/ephrin A reverse signaling promotes the migration of cortical interneurons from the medial ganglionic eminence.

SPRY1 EPHA4

1.77e-047102224381199
Pubmed

Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation.

CBLB PIK3CA

1.77e-047102227474268
Pubmed

Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin.

TEK TIE1

1.77e-047102227695111
Pubmed

Exome sequencing supports a de novo mutational paradigm for schizophrenia.

LAMA2 ADCY7 NPRL2

2.24e-0440102321822266
Pubmed

Regulation of membrane traffic by phosphoinositide 3-kinases.

PIK3C3 PIK3CA

2.36e-048102216467569
Pubmed

Role of vascular endothelial-cadherin in vascular morphogenesis.

TEK TIE1

2.36e-048102210207135
Pubmed

Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice.

TEK TIE1

2.36e-048102215644447
Pubmed

Bridging expressed sequence alignments through targeted cDNA sequencing.

HEATR1 USP51

2.36e-048102215028280
Pubmed

Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors.

EGF RBPJ

2.36e-048102215509736
Pubmed

Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.

ADCY2 ADCY7

3.03e-04910229417641
Pubmed

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

TEK TIE1

3.03e-04910228415706
Pubmed

Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development.

TEK TIE1

3.03e-04910229472016
Pubmed

Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.

ADCY2 ADCY7

3.03e-049102212503609
Pubmed

Role of the calcium modulated cyclases in the development of the retinal projections.

ADCY2 ADCY7

3.03e-049102217229090
Pubmed

Involvement of insulin-like growth factor 2 in angiogenic factor transcription in Bi-maternal mouse conceptuses.

TEK TIE1

3.03e-049102219881219
Pubmed

Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms.

SPRY1 EGF

3.03e-049102216339969
Pubmed

Genetic dissection of tie pathway in mouse lymphatic maturation and valve development.

TEK TIE1

3.03e-049102224764452
Pubmed

Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis.

RPS27 RPS27L

3.03e-049102225144937
Pubmed

The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF.

TEK TIE1

3.77e-0410102210395786
Pubmed

Protocadherin 12 deficiency alters morphogenesis and transcriptional profile of the placenta.

TEK TIE1

3.77e-0410102218477666
Pubmed

Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.

DLG4 PRKG1

3.77e-0410102222427743
Pubmed

Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.

PIK3C3 PIK3CA

3.77e-041010228798481
Pubmed

Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.

ADCY2 ADCY7

3.77e-0410102211884542
Cytoband1q44

OR2T1 OR2T10 OR2T34 OR2T11 OR2T3 OR2T6

1.84e-0711010261q44
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2T1 OR2T10 OR2T34 OR2T11 OR2T3 OR2T6

4.51e-071281026chr1q44
GeneFamilyOlfactory receptors, family 2

OR2T1 OR2T10 OR2T34 OR2T11 OR2T3 OR2T6

6.31e-06113736149
GeneFamilyImmunoglobulin like domain containing

CILP TEK IL1RAPL1 TIE1 CEACAM18 IL1RL1

1.29e-04193736594
GeneFamilyPhosphatidylinositol 3-kinase subunits

PIK3C3 PIK3CA

4.43e-048732831
GeneFamilyAdenylate cyclases|Deafness associated genes

ADCY2 ADCY7

7.09e-041073253
GeneFamilyUbiquitin specific peptidases

USP49 USP51 USP32

1.50e-0356733366
GeneFamilyCD molecules|I-set domain containing|Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing

IL1RAPL1 IL1RL1

1.63e-03157321296
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF142 ZBTB38 ZNF549 ZNF423 ZNF429 ZNF521 ZNF883 ZNF547 ZFP91

2.34e-0371873928
GeneFamilyFibronectin type III domain containing

TEK TIE1 ASTN1 EPHA4

4.00e-03160734555
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-6|TCGA-Liver / Sample_Type by Project: Shred V9

LAMA2 ZNF521 ADCY2 SVEP1 MAMDC2 LTBP2 PRKG1

1.27e-071691027e992530776cab922d0360b275fb9cb8bd0017b06
ToppCellCOVID-19-Endothelial_cells-Systemic_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

SPRY1 THSD7A ZNF423 ZNF521 TEK TIE1 EPHA4

2.36e-071851027f5e14181f45c37d13ee9e017a4c8bc248c353676
ToppCellCOVID-19-Heart-Fib_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

SPRY1 LAMA2 SVEP1 IL1RAPL1 MAMDC2 LTBP2 PRKG1

2.63e-071881027fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SPRY1 THSD7A LAMA2 CBLB SVEP1 IL1RAPL1 PRKG1

3.36e-0719510271cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCellIPF-Endothelial-VE_Peribronchial|IPF / Disease state, Lineage and Cell class

SPRY1 THSD7A ZNF423 ZNF521 TEK TIE1 EPHA4

3.36e-0719510272c3ad3cb79f11119ac69c413a938d21199145040
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SPRY1 LAMA2 ZNF521 SVEP1 MAMDC2 LTBP2 PRKG1

3.99e-07200102758b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF423 ZNF521 TEK TIE1 FZD10 TBCD

1.61e-061561026f894fac4e44a23718b20ad80c9677bf4f2118002
ToppCelldroplet-Marrow-nan-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC26A2 KBTBD8 RPS27 ADNP SCNN1A EPHA4

1.94e-0616110263f3a2148c8d65e6a06f8d8116a3aa58dda17d618
ToppCellControl-Endothelial_cells-Systemic_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

SPRY1 THSD7A ZNF423 ZNF521 TEK TIE1

2.84e-061721026c55dce1ed3ed7312394b4e050e1de852a994e130
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA2 CBLB SVEP1 LHFPL7 LTBP2 PRKG1

3.25e-0617610269bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA2 CBLB SVEP1 LHFPL7 LTBP2 PRKG1

3.25e-0617610263f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

SPRY1 LAMA2 SVEP1 IL1RAPL1 LTBP2 PRKG1

3.94e-061821026fbd5e332df73bf7141c822fa67b76367dc962017
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

THSD7A CILP ZNF521 ADCY7 IL1RAPL1 TADA2A

4.06e-061831026dc9602bed3136db91faeffef177006246dc92743
ToppCellCOVID-19-Heart-EC_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

THSD7A ZNF423 ZNF521 TEK TBCD EPHA4

4.06e-061831026ff95382cfed592190d0636d2b750328471f82e0d
ToppCellfacs-Skin-nan-24m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 LAMA2 ZNF521 ADCY7 SVEP1 PRKG1

4.33e-0618510268433a337625ff8398520e223ef92bf9bb0beb14c
ToppCellCOVID-19-Heart-Fib_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

CILP LAMA2 CBLB SVEP1 LTBP2 PRKG1

4.33e-0618510268f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCellfacs-Skin-nan-24m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 LAMA2 ZNF521 ADCY7 SVEP1 PRKG1

4.33e-061851026049d793d043d5d434f143025de49dd210d18756c
ToppCellfacs-Skin-nan-24m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 LAMA2 ZNF521 ADCY7 SVEP1 PRKG1

4.33e-06185102663200c42565eea596f9b00728e70e544b8d50a7f
ToppCellLA-01._Fibroblast_I|World / Chamber and Cluster_Paper

CILP LAMA2 CBLB SVEP1 MAMDC2 LTBP2

4.60e-0618710264ea486991f66c29728d127171a07b81404ec0b78
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

LAMA2 ZNF521 SVEP1 MAMDC2 LTBP2 PRKG1

4.60e-061871026bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellfacs-Skin-nan-18m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CILP LAMA2 ADCY2 SVEP1 PRKG1 DNAH6

4.89e-06189102629287525120be2953b76881ba3cfc4379c265e7a
ToppCellfacs-Skin-nan-18m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CILP LAMA2 ADCY2 SVEP1 PRKG1 DNAH6

4.89e-0618910267150dad9a92a715487c2d8130fa01b752ea69663
ToppCellCOVID-19-Heart-EC_(POSTN)|COVID-19 / Disease (COVID-19 only), tissue and cell type

THSD7A ZNF423 ZNF521 TEK PRKG1 EPHA4

4.89e-0618910267346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCellfacs-Skin-nan-18m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CILP LAMA2 ADCY2 SVEP1 PRKG1 DNAH6

4.89e-0618910266e4c0effd5192fd00052abc048fdb87a74fb6554
ToppCellLV-02._Fibroblast_II|World / Chamber and Cluster_Paper

SPRY1 LAMA2 CBLB SVEP1 MAMDC2 LTBP2

5.19e-061911026d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCelldroplet-Lung-30m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SPRY1 LAMA2 ADCY2 SVEP1 MAMDC2 PRKG1

5.35e-061921026ff4b728a55c2550c806c47e9ae3d057c35df8464
ToppCelldroplet-Lung-30m-Mesenchymal-fibroblast-alveolar_fibroblast|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SPRY1 LAMA2 ADCY2 SVEP1 MAMDC2 PRKG1

5.35e-0619210262d3790bd80a7f214b37094121a2a86ff16362569
ToppCellControl-Endothelial-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF423 ZNF521 TEK PPP3CA TIE1 RIPOR1

5.51e-061931026aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCellControl-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF423 ZNF521 TEK PPP3CA TIE1 RIPOR1

5.51e-061931026c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCellControl-Endothelial-Endothelial-Gen_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD7A ZNF423 ZNF521 TEK PPP3CA TIE1

5.51e-061931026e1d546165dcc2392f540162206852c4717d7306f
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

LAMA2 ZNF521 IL1RAPL1 MAMDC2 LTBP2 PRKG1

5.51e-061931026e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-3|TCGA-Stomach / Sample_Type by Project: Shred V9

CILP LAMA2 ZNF521 TEK SVEP1 LTBP2

5.68e-0619410262260cd817a6661e5eb6645b0c6786e18fd58371e
ToppCellLA-02._Fibroblast_II|LA / Chamber and Cluster_Paper

LAMA2 ZNF521 CBLB SVEP1 MAMDC2 LTBP2

5.68e-061941026234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

THSD7A LAMA2 RPS27 SVEP1 IL1RAPL1 PRKG1

5.68e-061941026a3e5a15cf6c1361207f661ee15eb634f77daf1cb
ToppCellIPF-Endothelial-VE_Peribronchial|World / Disease state, Lineage and Cell class

SPRY1 THSD7A ZNF423 ZNF521 TEK TIE1

5.85e-061951026120296531bbc8080dcabacbd64733cc1dc34603a
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CILP LAMA2 SVEP1 MAMDC2 LTBP2 PRKG1

5.85e-0619510261236dc60288c7dd91868e86e9174a2dacd3b11b3
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SPRY1 THSD7A RPS27 SVEP1 IL1RAPL1 PRKG1

6.02e-06196102622538376a95fe3afe8639a216a5497087aa94110
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPRY1 ZNF423 ZNF521 TEK TIE1 TBCD

6.20e-0619710260f467ef58f0c4dcc00b34b7b9639e03fb3ebe780
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA2 ZNF521 PATE2 SVEP1 MAMDC2 LTBP2

6.20e-06197102644673c38384453207871d3fd8e8ba9093cc06bc5
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

THSD7A LAMA2 CBLB SVEP1 IL1RAPL1 PRKG1

6.20e-06197102611a4c417f035e554431a8f03be13b5eefa3530c0
ToppCellASK452-Endothelial-Endothelium|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

SPRY1 SLC26A2 TEK TIE1 RIPOR1 IL1RL1

6.38e-061981026e282769f5fa1765bcce79a0ed9d761bf2e14b012
ToppCellAdult-Mesenchymal|Adult / Lineage, Cell type, age group and donor

LAMA2 ZNF521 SVEP1 MAMDC2 LTBP2 PRKG1

6.38e-06198102626e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

SPRY1 ZNF423 ZNF521 TEK TIE1 EPHA4

6.38e-0619810268689090bce9ab6e8f122426a404037e572c6713b
ToppCelldistal-2-mesenchymal-Adventitial_Fibroblast|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GDF5 CILP LAMA2 SVEP1 MAMDC2 LTBP2

6.57e-06199102697b475f9110ef7bb29d9cf2109b7e43177830f05
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-2,_SCARA5|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

CILP ZNF423 LAMA2 ZNF521 SVEP1 LTBP2

6.76e-0620010262022df85df94ab8cbb4e80e3fe9894c01051c5e0
ToppCellBronchus_Control_(B.)-Stromal-TX|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

CILP ZNF423 LAMA2 ZNF521 SVEP1 LTBP2

6.76e-06200102669b41f5fb370aa8840a9ad7919d03ef1e57d1b5b
ToppCellTracheal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA2 ZNF521 SVEP1 MAMDC2 LTBP2 PRKG1

6.76e-062001026b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SPRY1 LAMA2 SVEP1 MAMDC2 LTBP2 PRKG1

6.76e-062001026cb31cfcfa8e6d6cc610c4c22e97bc009dd8a9e7c
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SPRY1 ZNF423 LAMA2 ZNF521 IL1RAPL1 LTBP2

6.76e-062001026fb53be20392a8309a7393774c774a1b1aec6e676
ToppCellmild_COVID-19_(asymptomatic)-NK_CD56bright|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

TIE1 MAMDC2 SCNN1A DNAH6 EPHA4

2.55e-0515110252470162f4b56bc505db166a6eb0fa54847759df8
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

LAMA2 IL1RAPL1 MAMDC2 LTBP2 PRKG1

2.64e-051521025621e9b33cd3bb1c7b7d0633069f286b203e3d9c0
ToppCellmild_COVID-19_(asymptomatic)-NK_CD56bright|World / disease group, cell group and cell class (v2)

TIE1 MAMDC2 SCNN1A DNAH6 EPHA4

2.72e-051531025aff5c8ab1fb4ebc324cec02cf562b7484bb10db8
ToppCellChildren_(3_yrs)-Mesenchymal-chondrocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

LAMA2 SVEP1 MAMDC2 LTBP2 PRKG1

3.08e-051571025f147e24f2ece82e1c54750868954d09b3c461804
ToppCellChildren_(3_yrs)-Mesenchymal-chondrocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

LAMA2 SVEP1 MAMDC2 LTBP2 PRKG1

3.17e-051581025e5636c0b608d68bd426a2b446ac508e4512e86a4
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MUC19 LAMA2 ADCY2 SVEP1 ASTN1

3.37e-051601025c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MUC19 LAMA2 ADCY2 SVEP1 ASTN1

3.37e-05160102525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellAdult-Mesenchymal-chondrocyte-D231|Adult / Lineage, Cell type, age group and donor

CILP LAMA2 SVEP1 MAMDC2 LTBP2

3.79e-0516410252ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCellICU-NoSEP-Lymphocyte-T_NK-MAIT|ICU-NoSEP / Disease, Lineage and Cell Type

SPRY1 TRIP13 ADCY2 USP51 EPHA4

4.02e-051661025d3fa2e42497201f1ca57f4f977fbaa0def950033
ToppCell10x5'-lymph-node_spleen-Mast-Mast_cells|lymph-node_spleen / Manually curated celltypes from each tissue

THSD7A ZNF521 IL1RAPL1 ZNF547 IL1RL1

4.25e-051681025650ad3ea52577887885d82457dbc04202ce3eb34
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D231|Adult / Lineage, Cell type, age group and donor

THSD7A ZNF423 TEK TIE1 EPHA4

4.25e-051681025aca34c51758c65925ad24110294a72b2dea6db72
ToppCell10x5'-lymph-node_spleen-Mast|lymph-node_spleen / Manually curated celltypes from each tissue

THSD7A ZNF521 IL1RAPL1 ZNF547 IL1RL1

4.25e-051681025e58ffbb57c81967766755c3f6f347b158a39cb0d
ToppCellEndothelial-B-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

ZNF423 ZNF521 TEK TIE1 FZD10

4.37e-05169102595c617143e1fbdd1d55a93ffdcc210e0be37cf2f
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

USP49 NCAPD3 TEK TRIP13 EXO1

4.76e-0517210252b6cd84c946b1e800caba452ae70145ea285fec1
ToppCell-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

LAMA2 RPS27 SVEP1 MAMDC2 LTBP2

4.89e-05173102588be9182fbb1bc83531cd41e59ea57c112a21d54
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SIVA1 PATE2 TRIP13 EXO1 PRKG1

5.02e-0517410259f2e253694eb5860c00528fda31c305c6de8a2a1
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPRY1 LAMA2 LTB4R2 IL1RL1 PRKG1

5.30e-051761025e9152defb4fd41267fb33c42c01fd0c683280783
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPRY1 LAMA2 LTB4R2 IL1RL1 PRKG1

5.30e-051761025a4d269075aa0efc46fa251b379f334e50c69391d
ToppCellControl-Neuronal_cells-Neuronal_cells|Control / group, cell type (main and fine annotations)

SPRY1 THSD7A ZNF423 ZNF521 TIE1

5.30e-05176102598c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPRY1 LAMA2 LTB4R2 IL1RL1 PRKG1

5.30e-051761025cc6f65a7d2c622841c9d1ab3755586039d4ccc4d
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Drd1_(Deep_layer_pyramidal_cells)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

RPS27 PIK3C3 CDADC1 KDM2A UPP2

5.30e-0517610253c76a5c4ca2b378667cb155fbb9675519572b35d
ToppCellControl-Neuronal_cells|Control / group, cell type (main and fine annotations)

SPRY1 THSD7A ZNF423 ZNF521 TIE1

5.30e-051761025c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCell356C-Fibroblasts-Fibroblast-G|356C / Donor, Lineage, Cell class and subclass (all cells)

GDF5 SPRY1 SVEP1 MAMDC2 LTBP2

5.45e-0517710258220cc2fc0ee8764a67a3be51d75248be2453040
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

LAMA2 ADCY2 IL1RAPL1 LTBP2 PRKG1

5.45e-051771025b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCell356C-Fibroblasts-Fibroblast-G-|356C / Donor, Lineage, Cell class and subclass (all cells)

GDF5 SPRY1 SVEP1 MAMDC2 LTBP2

5.45e-0517710257617270f49cd6b7ba66db72d20560cee985012b2
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D231|Adult / Lineage, Cell type, age group and donor

THSD7A ZNF423 ZNF521 TEK TIE1

5.60e-051781025c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCelldroplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD7A TEK EGF TIE1 GPR137C

5.75e-051791025a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCellNS-critical-d_0-4-Myeloid-Mast_cell|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NR2C1 THSD7A MYH7B METTL25B IL1RL1

5.75e-0517910256153e7a0eeae83e7d88f1a20093bf2113e8d66b1
ToppCell390C-Lymphocytic-ILC-ILC-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PDE6B HEATR1 RBPJ USP32 DTX2

5.75e-0517910253edcd1356e49b1f5514c585861999e079ca5e579
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF423 ZNF521 TEK TIE1 EPHA4

5.75e-0517910258f9e538c822940785130297712b75131812a4603
ToppCell-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

LAMA2 RPS27 SVEP1 MAMDC2 LTBP2

5.75e-051791025e4224b2e9c4ae7da62cf670adf811f4112c7d060
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPRY1 ZNF521 TEK TIE1 TBCD

5.90e-05180102516728b9a1c52097e3a460534be71a476ecc54f0f
ToppCell10x5'-bone_marrow-Mast-Mast_cell_lympho|bone_marrow / Manually curated celltypes from each tissue

THSD7A ZNF521 METTL25B CDADC1 IL1RL1

6.06e-05181102556fa77ae31f3b7de6e441a439c33a11353b6573a
ToppCelltumor_Lymph_Node_/_Brain-Endothelial_cells|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

SPRY1 ZNF521 TEK TIE1 FZD10

6.22e-051821025d7cce5dd7046f06bf40f00c9dbfa610722b03333
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZNF423 TEK EGF TIE1 PRKG1

6.38e-0518310256f8f997ffc9eaebca2683de125b6069d07c07d26
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPRY1 ZNF521 TEK TIE1 TBCD

6.38e-051831025dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPRY1 ZNF521 TEK TIE1 TBCD

6.38e-0518310254759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF423 ZNF521 TEK TIE1 EXO1

6.55e-051841025688428103e8b19f45f2f65d70a0f30c904c8411c
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

SLC26A2 LAMA2 TEK SVEP1 IL1RAPL1

6.55e-05184102567164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D122|Adult / Lineage, Cell type, age group and donor

CILP LAMA2 ZNF521 SVEP1 MAMDC2

6.55e-0518410252b7e6f91e11c228f0521e099886867d9e998e78d
ToppCellCOVID-19-Neuronal_cells-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

THSD7A ZNF423 ZNF521 TEK TIE1

6.72e-0518510254a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCellCOVID-19-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

THSD7A ZNF423 ZNF521 TEK TIE1

6.72e-05185102536ce23893915f5c380cca39b2c33a516edf31c3a
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY1 LAMA2 ADCY2 SVEP1 MAMDC2

6.89e-051861025ca5e9c6531cb5d199e27509bfab1d62e3937177e
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY1 LAMA2 ADCY2 SVEP1 MAMDC2

6.89e-0518610251ed71b229f40a680071b14f5a7a19706e0fd14b1
ToppCellAdult-Endothelial-endothelial_cell_of_artery|Adult / Lineage, Cell type, age group and donor

THSD7A ZNF423 TEK TIE1 EPHA4

6.89e-0518610252d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF423 TEK TIE1 DNAH6 EPHA4

7.07e-0518710253548a9914c2b2f5d805798ce22ab26eab6d03897
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPRY1 ZNF521 TEK TIE1 TBCD

7.07e-05187102535c382c0aabd46906113e5db30ea24bb8e658899
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

THSD7A LAMA2 CBLB SVEP1 PRKG1

7.07e-051871025a9316e2818217ec5feae9cf8816f7249803caee6
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

LAMA2 SVEP1 MAMDC2 LTBP2 PRKG1

7.07e-05187102592d468dde81125d51daf7abd4703741abe1ab91c
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF423 TEK TIE1 DNAH6 EPHA4

7.07e-051871025f4de4b7af1fdfbd628b1f509c060c1079d2e5437
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC26A2 PATE2 LTB4R2 TRIP13 ASTN1

7.07e-051871025a2076599b33ae6750961b573bfebcb9036fa4ee8
DrugLevodopa [59-92-7]; Up 200; 20.2uM; MCF7; HT_HG-U133A

SPRY1 PGAP3 TWF2 CBLB ADCY2 ADCY7 TADA2A TBCD

2.98e-0619910181472_UP
Diseaseposterior thigh muscle volume

GDF5 ZBTB38 KDM2A

1.43e-0515953EFO_0020931
DiseaseGlaucoma 3, primary infantile, B

TEK LTBP2

3.07e-053952cv:C1832977
DiseaseGLAUCOMA 3, PRIMARY INFANTILE, B

TEK LTBP2

3.07e-053952600975
DiseaseGLAUCOMA 3, PRIMARY INFANTILE, B

TEK LTBP2

3.07e-053952C1832977
DiseaseHydrophthalmos

TEK LTBP2

1.02e-045952C0020302
DiseaseStevens-Johnson syndrome, toxic epidermal necrolysis, response to cold medicine

ZNF423 LAMA2 LTBP2

2.32e-0437953EFO_0004276, EFO_0004775, EFO_0006997
Disease2-hydroxystearate measurement

MUC19 TEK

3.64e-049952EFO_0021059
DiseaseAdult Hepatocellular Carcinoma

EGF PIK3CA

3.64e-049952C0279607
DiseaseMalformations of Cortical Development

PIK3CA TBCD

9.10e-0414952C1955869
DiseaseCortical Dysplasia

PIK3CA TBCD

9.10e-0414952C0431380
DiseaseGerm Cell Cancer

TRIP13 SCNN1A

1.05e-0315952C0740345
DiseaseGerm cell tumor

TRIP13 SCNN1A

1.05e-0315952C0205851
DiseaseNeoplasms, Embryonal and Mixed

TRIP13 SCNN1A

1.05e-0315952C0205852
DiseaseEmbryonal Neoplasm

TRIP13 SCNN1A

1.05e-0315952C0027654
DiseaseNeoplasms, Germ Cell and Embryonal

TRIP13 SCNN1A

1.05e-0315952C0027658
DiseaseCancer, Embryonal

TRIP13 SCNN1A

1.05e-0315952C0751364
DiseaseCancer, Embryonal and Mixed

TRIP13 SCNN1A

1.05e-0315952C0751365
Diseaseischemia (implicated_via_orthology)

ADNP SCNN1A

1.35e-0317952DOID:326 (implicated_via_orthology)
DiseaseFetal Alcohol Syndrome

ADNP PIK3CA

1.35e-0317952C0015923
Diseaseprion disease

ZBTB38 RCHY1

1.69e-0319952EFO_0004720
Diseasejuvenile idiopathic arthritis

ABCA13 LAMA2 PRKG1

1.78e-0374953EFO_0002609
Diseaseblood aluminium measurement

ZBTB38 EPHA4

1.88e-0320952EFO_0007575
DiseaseDisease Exacerbation

ABCA13 RCHY1 EGF PIK3CA

2.02e-03165954C0235874
Diseaseinfant body height

GDF5 ZBTB38

2.48e-0323952EFO_0006785
DiseaseAutism Spectrum Disorders

IL1RAPL1 DLG4 UPP2

2.64e-0385953C1510586
DiseaseCrohn's disease

ZBTB38 PGAP3 THSD7A MUC19 RBPJ IL1RL1

3.06e-03441956EFO_0000384
Diseaseresponse to angiotensin-converting enzyme inhibitor, response to angiotensin receptor blocker, angioedema

THSD7A KDM2A

3.17e-0326952EFO_0005325, EFO_0005532, EFO_0010735
Diseaseblood rubidium measurement

ABCA13 TEK

3.17e-0326952EFO_0021529

Protein segments in the cluster

PeptideGeneStartEntry
TYKCIHCLGVYTSNM

ADNP

661

Q9H2P0
VEMECICYSFLDLKY

CEACAM18

251

A8MTB9
MAILLSYCSILCNYK

AIG1

11

Q9NVV5
GMECLYGCYVHSSIV

CAMTA2

111

O94983
LCYGDMDKTIKVECY

CPNE3

201

O75131
KMFILGDTAYGSCCV

DPH2

76

Q9BQC3
YDMLFYLVSVCLCVA

ABCA13

4506

Q86UQ4
VCYMVQFVEETSYKC

CDADC1

196

Q9BWV3
MRIKILGDCYYCVSG

ADCY7

321

P51828
YNILMFCGCIEDYKL

ASTN1

686

O14525
CSLCKYRTFYEDEMA

AKAP8L

391

Q9ULX6
CNSMVKLCIDGYEYA

NR2C1

486

P13056
ATEIMCYECKKYHLG

PATE2

26

Q6UY27
KYHLGLCYGVMTSCS

PATE2

36

Q6UY27
ALFEIKMTTGYCIEC

MAMDC2

156

Q7Z304
DTALYETVMYVCCVL

OR2T1

241

O43869
VYKQYEDMVVESCGC

GDF5

486

P43026
DCIICMEKLSTASGY

DTX2

411

Q86UW9
VDCMYPVEYGKDSCI

PRKG1

116

Q13976
CYICKITKMSSANVY

GPR137C

221

Q8N3F9
ELYCEMGSTFQLCKI

CBLB

361

Q13191
CKIGYYKALSTDATC

EPHA4

276

P54764
MDILGFSVDEKCACY

MYH7B

381

A7E2Y1
YACVIRNSTYCMKVS

IL1RAPL1

116

Q9NZN1
FLLLVMAYDCYVAIC

OR4A47

111

Q6IF82
SVMAYDCYVAICKPL

OR4C45

111

A6NMZ5
DKTTYETVMYVCCVA

OR2T6

191

Q8NHC8
CDMEGKYLGFCTAVA

MUC19

1501

Q7Z5P9
CTELDLVKCGIQMYY

PDE6B

511

P35913
VTQECAEYCALYEKM

EVPLL

81

A8MZ36
YSVKDISVGGMCICY

LAMA2

276

P24043
EVVALASVGCCYMKL

METTL25B

276

Q96FB5
DVSLYKMLTYLCCIL

OR2T34

196

Q8NGX1
DVSLYKTLMYLCCIL

OR2T3

196

Q8NH03
LLASMSYDCYVAICK

OR6C76

111

A6NM76
LLLESYCRACGMYLK

PIK3CA

686

P42336
IGCKLVYCCGKMYAI

KBTBD8

381

Q8NFY9
TRYDIDMTKCIYCGF

NDUFS8

141

O00217
DTSLYKIFMYLCCVI

OR2T10

191

Q8NGZ9
YLSCLEELMKCQIIY

TRIP13

331

Q15645
LSMCYCVYSVGYLIR

FZD10

266

Q9ULW2
CMRIKILGDCYYCVS

ADCY2

331

Q08462
ELCYHLSFMGLCYIE

DNAH6

321

Q9C0G6
LSFMGLCYIEKCHTY

DNAH6

326

Q9C0G6
NKCGYTLCIYGRDML

IL1RL1

411

Q01638
VQKYCLMSVRGCYTD

KDM2A

196

Q9Y2K7
MYIEALDKYACNCVV

EGF

991

P01133
IYALDCEMCYTTHGL

REXO1L1P

501

Q8IX06
MDCLCIVTTKKYRYQ

DLG4

1

P78352
SYHCECDQGYIMVRK

LTBP2

951

Q14767
TEYCEYMPDVAKCRQ

DENR

41

O43583
LLYAIGGECLYSMEC

KLHDC7B

406

Q96G42
CLTYCDDMSVYAVGS

DCAF12L1

311

Q5VU92
VRKYSCDLCYTPMIV

DUS4L

46

O95620
CVYSCPSYIAKDLMK

HEATR1

1006

Q9H583
VKCARYDGSSDCLMY

CLDN12

56

P56749
ISLYNTCMKVVYIAC

KDELR1

56

P24390
VCEASSMYYGGKCRL

LHFPL7

136

Q6ICI0
SLACMSKYSAGCIYY

SEC24B

876

O95487
FQESMIKECGCAYIF

SCNN1A

421

P37088
CKIKYSERVYDACMD

PPP3CA

166

Q08209
LLGLMAYDCYVAVCN

OR2T11

111

Q8NH01
RKCIASSGCFMEYLE

RNF180

26

Q86T96
DDCKYECMWVTVGLY

PGAP3

66

Q96FM1
LVVMAYDCYVAICKP

OR4C5

136

Q8NGB2
KAKTMCECYDYLFDI

APIP

206

Q96GX9
CECYDYLFDIAVSMK

APIP

211

Q96GX9
DAAAGMEYLESKCCI

FES

666

P07332
IKDICAGTDRYCMYK

UPP2

91

O95045
EQMLETKSCYDGQCY

THSD7A

1461

Q9UPZ6
SSYLMEPYIKCAECG

TADA2A

21

O75478
MAELGKKYCVYCLAE

TADA2B

1

Q86TJ2
QAGCKAVYYVCALSM

LTB4R2

91

Q9NPC1
YFMDVKCPGCYKITT

RPS27L

31

Q71UM5
VMDTYVKSCAGYCVI

PIK3C3

721

Q8NEB9
YESYGECVVALKSMI

INPPL1

831

O15357
LGKYMACCLLYRGDV

TUBAL3

316

A6NHL2
YDEICCKTGMSYHEL

NPRL2

351

Q8WTW4
MLYKTTCLVACDEGY

SVEP1

456

Q4LDE5
ECKLCPSGMYTEYIH

SVEP1

1031

Q4LDE5
TEEKFRYMCILSGCD

EXO1

211

Q9UQ84
RYMCILSGCDYLSSL

EXO1

216

Q9UQ84
VSAACLEFKCSGMLY

CILP

1001

O75339
CDLCIRYTIMVDKYI

NCAPD3

966

P42695
VDLYHGVIYCFMCKD

USP51

276

Q70EK9
YVCMECGKSFIHSYD

ZNF549

361

Q6P9A3
ICDKSCYAIMVGSTV

SLC26A2

211

P50443
GTPYCGMTCAELYEK

TIE1

1051

P35590
YGCDICGAAYTMETL

ZNF521

886

Q96K83
AMEVRDLYVFCYLCK

USP49

66

Q70CQ1
VEYGTCMCLVKGIFY

SPRY1

216

O43609
GTPYCGMTCAELYEK

TEK

1036

Q02763
CAFYLKDTERMYLCL

RBPJ

286

Q06330
ERTYKCSKCGILFME

ZNF547

181

Q8IVP9
CLTLTQSKMYHCDIY

ZNF429

136

Q86V71
SQIYCALLGCMDDYT

TBCD

846

Q9BTW9
TCYEEMLKEGYRCPL

RCHY1

171

Q96PM5
IYMTANPYLCTECGK

ZNF883

6

P0CG24
ECLLLEAEGMSKSYC

ZFP91

506

Q96JP5
YGCDICGAAYTMEVL

ZNF423

886

Q2M1K9
GQMLYSCVVCKRSYV

ZBTB38

456

Q8NAP3
HSNTKDYMCTECGYV

ZNF142

451

P52746
RLCVGDQYEICMKYG

RIPOR1

221

Q6ZS17
YFMDVKCPGCYKITT

RPS27

31

P42677
TLCGLVDCSDMYEKV

SIVA1

151

O15304
GYKCSIKERMLYSSC

TWF2

261

Q6IBS0
EELGENEMYYCSKCK

USP32

1246

Q8NFA0