Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR2 RYR3 ITPR3	5.40e-05	18	83	3	GO:0015278
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR2 RYR3	1.02e-04	4	83	2	GO:0005219
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR2 RYR3	2.53e-04	6	83	2	GO:0048763
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	RYR2 RYR3 ITPR3	2.86e-04	31	83	3	GO:0099604
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR2 RYR3 ITPR3	3.45e-04	33	83	3	GO:0005217
GeneOntologyMolecularFunction	olfactory receptor activity	OR2A7 OR10G3 OR1Q1 OR2A4 OR2W1 OR2V1 OR2Z1 OR52A1	4.24e-04	431	83	8	GO:0004984
GeneOntologyCellularComponent	lamellipodium membrane	DPP4 DOCK8 PIEZO1	8.80e-05	22	83	3	GO:0031258
GeneOntologyCellularComponent	muscle tendon junction	NRAP ITGA7	2.31e-04	6	83	2	GO:0005927
GeneOntologyCellularComponent	Flemming body	OR2A7 STK17B OR2A4	3.92e-04	36	83	3	GO:0090543
Domain	RIH_assoc	RYR2 RYR3 ITPR3	1.56e-06	6	81	3	PF08454
Domain	RIH_assoc-dom	RYR2 RYR3 ITPR3	1.56e-06	6	81	3	IPR013662
Domain	RIH_dom	RYR2 RYR3 ITPR3	1.56e-06	6	81	3	IPR000699
Domain	Ins145_P3_rcpt	RYR2 RYR3 ITPR3	1.56e-06	6	81	3	IPR014821
Domain	Ryanodine_recept-rel	RYR2 RYR3 ITPR3	1.56e-06	6	81	3	IPR015925
Domain	-	RYR2 RYR3 ITPR3	1.56e-06	6	81	3	1.25.10.30
Domain	RYDR_ITPR	RYR2 RYR3 ITPR3	1.56e-06	6	81	3	PF01365
Domain	Ins145_P3_rec	RYR2 RYR3 ITPR3	1.56e-06	6	81	3	PF08709
Domain	MIR	RYR2 RYR3 ITPR3	9.23e-06	10	81	3	PS50919
Domain	MIR	RYR2 RYR3 ITPR3	9.23e-06	10	81	3	PF02815
Domain	MIR	RYR2 RYR3 ITPR3	9.23e-06	10	81	3	SM00472
Domain	MIR_motif	RYR2 RYR3 ITPR3	9.23e-06	10	81	3	IPR016093
Domain	Ryanrecept_TM4-6	RYR2 RYR3	5.56e-05	3	81	2	IPR009460
Domain	RyR	RYR2 RYR3	5.56e-05	3	81	2	PF02026
Domain	Ryanodine_rcpt	RYR2 RYR3	5.56e-05	3	81	2	IPR003032
Domain	RR_TM4-6	RYR2 RYR3	5.56e-05	3	81	2	PF06459
Domain	Ryan_recept	RYR2 RYR3	5.56e-05	3	81	2	IPR013333
Domain	Olfact_rcpt	OR2A7 OR10G3 OR1Q1 OR2A4 OR2W1 OR2V1 OR2Z1 OR52A1	3.02e-04	393	81	8	IPR000725
Domain	ARM-like	DOCK8 MROH5 HEATR5B MED12 XPOT ARMC8	1.13e-03	270	81	6	IPR011989
Domain	CYTOCHROME_B5_2	HERC2 CYB5D1	1.40e-03	13	81	2	PS50255
Domain	CYTOCHROME_B5_1	HERC2 CYB5D1	1.40e-03	13	81	2	PS00191
Domain	Cyt-b5	HERC2 CYB5D1	1.63e-03	14	81	2	PF00173
Domain	Cyt_B5-like_heme/steroid-bd	HERC2 CYB5D1	1.63e-03	14	81	2	IPR001199
Domain	Cyt-b5	HERC2 CYB5D1	1.63e-03	14	81	2	SM01117
Domain	-	HERC2 CYB5D1	1.63e-03	14	81	2	3.10.120.10
Domain	GPCR_Rhodpsn_7TM	OR2A7 OR10G3 OR1Q1 OR2A4 OR2W1 OR2V1 OR2Z1 F2R OR52A1	2.43e-03	670	81	9	IPR017452
Domain	Sulfatase	PIGG ARSG	2.72e-03	18	81	2	PF00884
Domain	Sulfatase_N	PIGG ARSG	2.72e-03	18	81	2	IPR000917
Domain	-	MROH5 HEATR5B MED12 XPOT ARMC8	2.79e-03	222	81	5	1.25.10.10
Domain	G_PROTEIN_RECEP_F1_1	OR2A7 OR10G3 OR1Q1 OR2A4 OR2W1 OR2V1 OR2Z1 F2R OR52A1	2.82e-03	685	81	9	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2A7 OR10G3 OR1Q1 OR2A4 OR2W1 OR2V1 OR2Z1 F2R OR52A1	2.99e-03	691	81	9	PS50262
Domain	GPCR_Rhodpsn	OR2A7 OR10G3 OR1Q1 OR2A4 OR2W1 OR2V1 OR2Z1 F2R OR52A1	3.02e-03	692	81	9	IPR000276
Domain	PRAME_family	PRAMEF19 PRAMEF18	3.03e-03	19	81	2	IPR026271
Domain	ARM-type_fold	DOCK8 MROH5 HEATR5B RYR3 XPOT ARMC8	3.54e-03	339	81	6	IPR016024
Domain	zf-DHHC	ZDHHC12 ZDHHC17	4.43e-03	23	81	2	PF01529
Domain	DHHC	ZDHHC12 ZDHHC17	5.22e-03	25	81	2	PS50216
Domain	Znf_DHHC_palmitoyltrfase	ZDHHC12 ZDHHC17	5.22e-03	25	81	2	IPR001594
Domain	Alkaline_phosphatase_core	PIGG ARSG	7.96e-03	31	81	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	PIGG ARSG	7.96e-03	31	81	2	IPR017849
Domain	-	PIGG ARSG	7.96e-03	31	81	2	3.40.720.10
Domain	Serpin_CS	SERPINE2 SERPINE1	8.47e-03	32	81	2	IPR023795
Pubmed	Activated Protein C Protects against Murine Contact Dermatitis by Suppressing Protease-Activated Receptor 2.	SERPINE2 SERPINE1 F2R	1.35e-07	5	84	3	35008942
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR2 RYR3 ITPR3	2.70e-07	6	84	3	23463619
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR2 RYR3 ITPR3	2.70e-07	6	84	3	25966694
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR2 RYR3 ITPR3	2.70e-07	6	84	3	20519450
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR2 RYR3 ITPR3	2.70e-07	6	84	3	16844763
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR2 RYR3 ITPR3	4.72e-07	7	84	3	11860456
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR2 RYR3 ITPR3	7.54e-07	8	84	3	19033399
Pubmed	Defining the membrane proteome of NK cells.	DPP4 DOCK8 PTRH2 ATP11A ERMP1 PIGG HERC2 TUBGCP4 HEATR5B MED12 GAA SLC27A3 ITPR3	4.44e-06	1168	84	13	19946888
Pubmed	The role of thrombin receptors PAR1 and PAR4 for PAI-1 storage, synthesis and secretion by human platelets.	SERPINE1 F2R	5.76e-06	2	84	2	22283974
Pubmed	Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: the MESA-RV Study.	SERPINE1 MMP9	5.76e-06	2	84	2	20923324
Pubmed	Possible effects of plasminogen activator inhibitor-1 on promoting angiogenesis through matrix metalloproteinase 9 in advanced mycosis fungoides.	SERPINE1 MMP9	5.76e-06	2	84	2	38287534
Pubmed	Expression of plasminogen activator inhibitor-1 and protease nexin-1 in human astrocytes: Response to injury-related factors.	SERPINE2 SERPINE1	5.76e-06	2	84	2	20623540
Pubmed	Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.	RYR2 RYR3	5.76e-06	2	84	2	8898078
Pubmed	Effects of novel chalcone derivatives on α-glucosidase, dipeptidyl peptidase-4, and adipocyte differentiation in vitro.	DPP4 GAA	5.76e-06	2	84	2	21699755
Pubmed	Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells.	RYR2 ITPR3	5.76e-06	2	84	2	18586264
Pubmed	The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.	RYR2 RYR3	5.76e-06	2	84	2	14550562
Pubmed	Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation.	MMP9 F2R	5.76e-06	2	84	2	32809114
Pubmed	Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.	RYR2 RYR3	5.76e-06	2	84	2	21531043
Pubmed	Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.	RYR2 RYR3	5.76e-06	2	84	2	16678258
Pubmed	Regulatory mechanisms and pathophysiological significance of IP3 receptors and ryanodine receptors in drug dependence.	RYR2 ITPR3	5.76e-06	2	84	2	24285081
Pubmed	Elevated plasma plasminogen activator inhibitor-1 in CD36 deficiency.	DPP4 SERPINE1	5.76e-06	2	84	2	18820218
Pubmed	Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes.	RYR2 RYR3	5.76e-06	2	84	2	14985349
Pubmed	Anticoagulant and antithrombotic properties of platelet protease nexin-1.	SERPINE2 SERPINE1	5.76e-06	2	84	2	19855083
Pubmed	Inhibition of PAI-1 attenuates perirenal fat inflammation and the associated nephropathy in high-fat diet-induced obese mice.	SERPINE2 SERPINE1	5.76e-06	2	84	2	30532990
Pubmed	Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes.	SERPINE2 SERPINE1	1.73e-05	3	84	2	9184208
Pubmed	Specificity of binding of the low density lipoprotein receptor-related protein to different conformational states of the clade E serpins plasminogen activator inhibitor-1 and proteinase nexin-1.	SERPINE2 SERPINE1	1.73e-05	3	84	2	19439404
Pubmed	Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation.	PIEZO1 ATP11A	1.73e-05	3	84	2	29799007
Pubmed	Restricted feeding induces daily expression of clock genes and Pai-1 mRNA in the heart of Clock mutant mice.	SERPINE2 SERPINE1	1.73e-05	3	84	2	12208516
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR2 RYR3	1.73e-05	3	84	2	18403125
Pubmed	Inhibition of plasminogen activator inhibitor type-1 activity enhances rapid and sustainable hematopoietic regeneration.	SERPINE2 SERPINE1	1.73e-05	3	84	2	24155177
Pubmed	PTRH2 gene mutation causes progressive congenital skeletal muscle pathology.	PTRH2 ITGA7	1.73e-05	3	84	2	28175314
Pubmed	Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.	RYR2 RYR3	1.73e-05	3	84	2	29730765
Pubmed	Comparative analysis of AKT and the related biomarkers in uterine leiomyomas with MED12, HMGA2, and FH mutations.	FH MED12	1.73e-05	3	84	2	29790226
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR2 RYR3	1.73e-05	3	84	2	7876312
Pubmed	PAR-1 mediates the thrombin-induced mesothelial cell overproduction of VEGF and PAI-1.	SERPINE1 F2R	1.73e-05	3	84	2	23280079
Pubmed	The expansion of the PRAME gene family in Eutheria.	PRAMEF19 PRAMEF18	1.73e-05	3	84	2	21347312
Pubmed	Systemic inhibition of the angiotensin-converting enzyme limits lipopolysaccharide-induced lung neutrophil recruitment through both bradykinin and angiotensin II-regulated pathways.	SERPINE2 SERPINE1	1.73e-05	3	84	2	17082641
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR2 RYR3	1.73e-05	3	84	2	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR2 RYR3	1.73e-05	3	84	2	10788707
Pubmed	Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation.	OR2A7 OR2A4	1.73e-05	3	84	2	27315375
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR2 RYR3	1.73e-05	3	84	2	7621815
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR2 RYR3	1.73e-05	3	84	2	10473538
Pubmed	Expression of thrombin and its associated protein in cerebellum of human and rat after intracerebral hemorrhage.	SERPINE2 F2R	1.73e-05	3	84	2	20819545
Pubmed	Local and systemic expressions of MMP-9, TIMP-1 and PAI-1 in patients undergoing surgery for clinically suspected appendicitis.	SERPINE1 MMP9	1.73e-05	3	84	2	22516898
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR2 RYR3	1.73e-05	3	84	2	18434746
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR2 RYR3	1.73e-05	3	84	2	9204703
Pubmed	Tubular network formation by adriamycin-resistant MCF-7 breast cancer cells is closely linked to MMP-9 and VEGFR-2/VEGFR-3 over-expressions.	FLT4 MMP9	1.73e-05	3	84	2	22542663
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR2 RYR3	1.73e-05	3	84	2	21881589
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR2 RYR3	1.73e-05	3	84	2	12213830
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR2 RYR3	1.73e-05	3	84	2	9242641
Pubmed	RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle.	RYR2 RYR3	1.73e-05	3	84	2	15024040
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR2 RYR3	1.73e-05	3	84	2	25239916
Pubmed	Resistin Promotes Thrombosis in Rats with Deep Vein Thrombosis via Up-Regulating MMP-2, MMP-9, and PAI-1.	SERPINE1 MMP9	1.73e-05	3	84	2	31625370
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR2 RYR3	1.73e-05	3	84	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR2 RYR3	1.73e-05	3	84	2	11159936
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR2 RYR3	1.73e-05	3	84	2	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR2 RYR3	1.73e-05	3	84	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR2 RYR3	1.73e-05	3	84	2	7635066
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2A7 OR10G3 OR1Q1 OR2A4 OR2W1 OR2V1 OR2Z1	1.91e-05	340	84	7	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2A7 OR10G3 OR1Q1 OR2A4 OR2W1 OR2V1 OR2Z1	1.91e-05	340	84	7	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2A7 OR10G3 OR1Q1 OR2A4 OR2W1 OR2V1 OR2Z1	2.02e-05	343	84	7	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2A7 OR10G3 OR1Q1 OR2A4 OR2W1 OR2V1 OR2Z1	2.13e-05	346	84	7	14611657
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR3 ITPR3	3.45e-05	4	84	2	22100703
Pubmed	A zonal organization of odorant receptor gene expression in the olfactory epithelium.	OR2A7 OR2A4	3.45e-05	4	84	2	7683976
Pubmed	Modulation of PAI-1 and proMMP-9 syntheses by soluble TNFalpha and its receptors during differentiation of the human monocytic HL-60 cell line.	SERPINE1 MMP9	3.45e-05	4	84	2	12811828
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR2 RYR3	3.45e-05	4	84	2	23413940
Pubmed	Accumulation of gene polymorphisms related to plaque disruption and thrombosis is associated with cerebral infarction in subjects with type 2 diabetes.	SERPINE1 MMP9	3.45e-05	4	84	2	19933990
Pubmed	Fibrin(ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury.	SERPINE1 MMP9	3.45e-05	4	84	2	22507835
Pubmed	Prothrombotic gene polymorphisms and atherothrombotic cerebral infarction.	SERPINE2 SERPINE1	3.45e-05	4	84	2	12859287
Pubmed	Upregulation of urokinase-type plasminogen activator and inhibitor and gelatinase expression via 3 mitogen-activated protein kinases and PI3K pathways during the early development of osteoarthritis.	SERPINE1 MMP9	3.45e-05	4	84	2	17299841
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR2 RYR3	3.45e-05	4	84	2	9607712
Pubmed	Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26.	SERPINE2 SERPINE1	3.45e-05	4	84	2	10992299
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR2 RYR3	3.45e-05	4	84	2	23482488
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR2 RYR3	3.45e-05	4	84	2	18206662
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR2 RYR3	3.45e-05	4	84	2	9384575
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	SERPINE2 CYBRD1 DOLK SERPINE1 PTRH2 PAQR5 ERMP1 VPS16 FH DEGS1 XPOT	4.92e-05	1061	84	11	33845483
Pubmed	Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells.	SERPINE1 MMP9	5.74e-05	5	84	2	27283026
Pubmed	Genotype-phenotype relationships in an investigation of the role of proteases in abdominal aortic aneurysm expansion.	SERPINE1 MMP9	5.74e-05	5	84	2	16082623
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR2 RYR3	5.74e-05	5	84	2	23918386
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR2 RYR3	5.74e-05	5	84	2	19011160
Pubmed	Macrophages of M1 phenotype have properties that influence lung cancer cell progression.	SERPINE1 MMP9	5.74e-05	5	84	2	26050228
Pubmed	Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.	RYR2 RYR3	5.74e-05	5	84	2	33060591
Pubmed	Duplication and positive selection among hominin-specific PRAME genes.	PRAMEF19 PRAMEF18	5.74e-05	5	84	2	16159394
Pubmed	Secretion of MMP-2 and MMP-9 induced by VEGF autocrine loop correlates with clinical features in childhood acute lymphoblastic leukemia.	FLT4 MMP9	5.74e-05	5	84	2	18829111
Pubmed	Early embryonic expression of murine coagulation system components.	SERPINE2 SERPINE1 F2R	7.70e-05	34	84	3	11154109
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR2 RYR3	8.59e-05	6	84	2	19549818
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR2 RYR3	8.59e-05	6	84	2	26025922
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR2 RYR3	8.59e-05	6	84	2	14592808
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR2 RYR3	8.59e-05	6	84	2	19009018
Pubmed	Mcp-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes in hepatopulmonary syndrome.	SERPINE2 SERPINE1	8.59e-05	6	84	2	17934860
Pubmed	Genes predisposing to rapid aneurysm growth.	SERPINE1 MMP9	8.59e-05	6	84	2	17182940
Pubmed	ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice.	RYR2 ITPR3	8.59e-05	6	84	2	16352659
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	PDXDC1 RAB3GAP2 NUP88 PTRH2 ZDHHC17 HEATR5B GAA SLC27A3 XPOT ITPR3	9.15e-05	942	84	10	31073040
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	RYR2 RYR3 ITPR3	1.08e-04	38	84	3	30786075
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR2 RYR3	1.20e-04	7	84	2	20962236
Pubmed	The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.	HERC2 HERC2P3	1.20e-04	7	84	2	9949213
Pubmed	Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study.	SERPINE1 MMP9	1.60e-04	8	84	2	16356191
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR2 RYR3	1.60e-04	8	84	2	11784029
Pubmed	The genetics of abdominal aortic aneurysms: a comprehensive meta-analysis involving eight candidate genes in over 16,700 patients.	SERPINE1 MMP9	1.60e-04	8	84	2	20302034
Pubmed	Saturation mutagenesis defines novel mouse models of severe spine deformity.	OR2A7 OR2A4	1.60e-04	8	84	2	34142127
Interaction	GPR17 interactions	PDXDC1 STK17B DOLK ERMP1 PIGG TUBGCP4 HEATR5B DEGS1 XPOT	1.31e-06	283	77	9	int:GPR17
Interaction	FPR2 interactions	PDXDC1 PIEZO1 DOLK ERMP1 PIGG TUBGCP4	1.47e-05	138	77	6	int:FPR2
Interaction	C3orf52 interactions	NAT8L FLT4 TMEM45B PIEZO1 FBXO7 ERMP1 SLC27A3 ITPR3	2.14e-05	305	77	8	int:C3orf52
Cytoband	15q15	SLC28A2 TUBGCP4	2.11e-04	12	83	2	15q15
Cytoband	1q21	ACP6 CELF3 PGLYRP3	6.17e-04	91	83	3	1q21
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR2 RYR3	3.03e-05	3	58	2	287
GeneFamily	Olfactory receptors, family 2	OR2A7 OR2A4 OR2W1 OR2V1 OR2Z1	3.07e-05	113	58	5	149
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC12 ZDHHC17	2.67e-03	24	58	2	76
GeneFamily	PRAME family	PRAMEF19 PRAMEF18	2.67e-03	24	58	2	686
GeneFamily	Ataxins\|Trinucleotide repeat containing	CELF3 MED12	2.89e-03	25	58	2	775
GeneFamily	Serpin peptidase inhibitors	SERPINE2 SERPINE1	6.27e-03	37	58	2	739
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-suprabasal_interpapillary\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP4 TMEM45B SLC39A11 PAQR5 ALAD ERMP1	1.72e-06	192	84	6	44cb225392c8d07150955ecf203fbdf6021c9790
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAT8L LINGO1 NDST4 SLC17A7 MMP9	1.13e-05	155	84	5	72a19a9ecfd13f6769c4b447d3ce01a855ec6ec7
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Teffector/EM_CD4\|GI_large-bowel / Manually curated celltypes from each tissue	PIEZO1 SLC28A2 ERMP1 MMP9 MED12	1.16e-05	156	84	5	01f2c0c6a936dfb59bc727feef428a906ad2a80b
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP4 SLC39A11 PAQR5 PNCK CYB5D1	1.35e-05	161	84	5	ed93cb6c133855a5c244821e1a260aae8ab4df9a
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP4 SLC39A11 PAQR5 PNCK CYB5D1	1.35e-05	161	84	5	0089d7bb305c592392791862a3341fc92af8f3e2
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAT8L LINGO1 NDST4 SLC17A7 RYR2	2.78e-05	187	84	5	e04a84989d624378141042768383b9c846901f2d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAT8L LINGO1 NDST4 SLC17A7 RYR2	2.78e-05	187	84	5	24cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAT8L LINGO1 NDST4 SLC17A7 RYR2	2.78e-05	187	84	5	2f153b203fe79f206319603cf94d3a03ab49a05d
ToppCell	droplet-Lung-LUNG-30m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SERPINE2 CYBRD1 GUCY1B1 SLC17A7 F2R	2.78e-05	187	84	5	976b74d081b7fba8620768613cc26f9262cd7b16
ToppCell	11.5-Airway-Epithelial-Bud_tip_progenitor\|Airway / Age, Tissue, Lineage and Cell class	NAT8L DPP4 ASPG ATP11A ITPR3	3.23e-05	193	84	5	f0a07bb221a497a9f7cc706045d5205269be4515
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-keratinocyte\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP4 TMEM45B SLC39A11 PAQR5 ERMP1	3.40e-05	195	84	5	c54b19e31efe2c9ae690062569da7c0f1120a1d8
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO3A SERPINE2 LINGO1 GUCY1B1 ITGA7	3.48e-05	196	84	5	88dc4e3efd7ea07617ecde142ec47cc57608f81b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Interneuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	TMEM45B RBL2 PIEZO1 SERPINE1 PNCK	3.83e-05	200	84	5	a6500d0d2e8bcac92381ab771dbdee66b0e1d48e
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR2 RYR3 ITPR3	1.50e-06	7	81	3	CID009547999
Drug	Br2BAPTA	RYR2 RYR3 ITPR3	1.50e-06	7	81	3	CID003081001
Drug	lercanidipine	MMP9 DEGS1 RYR2 RYR3 ITPR3	3.01e-06	63	81	5	CID000065866
Drug	R 478	RYR2 RYR3 ITPR3	7.01e-06	11	81	3	CID000084223
Drug	8-amino-cADPR	RYR2 RYR3 ITPR3	7.01e-06	11	81	3	CID003081323
Drug	4-chloro-m-cresol	FH RYR2 RYR3 ITPR3	8.98e-06	37	81	4	CID000001732
Drug	Gvapspat amide	RYR2 RYR3 ITPR3	1.91e-05	15	81	3	CID000125015
Drug	etridiazole	FLT4 SERPINE1 RYR2 RYR3	3.02e-05	50	81	4	CID000017432
Drug	guanidinoacetate	FLT4 SLC28A2 FH GAA	3.53e-05	52	81	4	CID000000763
Drug	cis-diammineplatinum(II	RYR2 RYR3	3.74e-05	3	81	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR2 RYR3	3.74e-05	3	81	2	CID002750949
Drug	8N3-cADPR	RYR2 RYR3	3.74e-05	3	81	2	CID000127713
Drug	aminodantrolene	RYR2 RYR3	3.74e-05	3	81	2	CID009570289
Drug	AC1NE3ZL	ALAD CABIN1	3.74e-05	3	81	2	CID004636206
Drug	2-hydroxycarbazole	RYR2 RYR3	3.74e-05	3	81	2	CID000093551
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR2 RYR3	3.74e-05	3	81	2	CID005748312
Drug	AC1L1KRB	RBL2 CABIN1 F2R RYR3	4.11e-05	54	81	4	CID000005621
Drug	Cinildipine	SERPINE1 RYR2 RYR3 ITPR3	4.74e-05	56	81	4	CID000002752
Drug	creatine	MYO3A SLC28A2 SLC17A7 GAA RYR2 RYR3	6.57e-05	193	81	6	CID000000586
Drug	IAA-94	FLT4 RYR2 RYR3 ITPR3	6.65e-05	61	81	4	CID000003667
Drug	PCB74	RYR2 RYR3	7.47e-05	4	81	2	CID000036218
Drug	148504-47-6	RYR2 RYR3	7.47e-05	4	81	2	CID006444275
Drug	SC 38249	RYR2 RYR3	7.47e-05	4	81	2	CID000134834
Drug	AC1L1U7A	RYR2 RYR3	7.47e-05	4	81	2	CID000035682
Drug	arabinosyladenine	DPP4 PDE4C GUCY1B1 RBL2 SLC28A2 ATP11A MMP9 F2R RYR2 RYR3 ITPR3	7.89e-05	762	81	11	CID000000191
Drug	thioridazine hydrochloride; Down 200; 10uM; PC3; HT_HG-U133A	RAB3GAP2 ATP11A NOL10 FH F2R MED12	8.00e-05	200	81	6	5921_DN
Drug	T0702	RYR2 RYR3 ITPR3	9.43e-05	25	81	3	CID000005908
Drug	gallopamil	DEGS1 RYR2 RYR3 ITPR3	9.61e-05	67	81	4	CID000001234
Disease	brain edema (biomarker_via_orthology)	SERPINE2 MMP9 F2R	7.90e-06	15	78	3	DOID:4724 (biomarker_via_orthology)
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR2 RYR3	2.07e-05	3	78	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR2 RYR3	2.07e-05	3	78	2	DOID:8545 (implicated_via_orthology)
Disease	familial hypercholesterolemia (is_marker_for)	SERPINE1 MMP9	2.07e-05	3	78	2	DOID:13810 (is_marker_for)
Disease	familial encephalopathy with neuroserpin inclusion bodies (implicated_via_orthology)	SERPINE2 SERPINE1	4.12e-05	4	78	2	DOID:0050831 (implicated_via_orthology)
Disease	Lead Poisoning	ALAD MMP9	1.44e-04	7	78	2	C0023176
Disease	abdominal aortic aneurysm (implicated_via_orthology)	SERPINE1 MMP9	2.45e-04	9	78	2	DOID:7693 (implicated_via_orthology)
Disease	interstitial lung disease (is_implicated_in)	SERPINE1 MMP9	3.06e-04	10	78	2	DOID:3082 (is_implicated_in)
Disease	glomerulosclerosis (biomarker_via_orthology)	SERPINE1 MMP9	3.06e-04	10	78	2	DOID:0050851 (biomarker_via_orthology)
Disease	glomerulosclerosis (implicated_via_orthology)	SERPINE1 MMP9	3.74e-04	11	78	2	DOID:0050851 (implicated_via_orthology)
Disease	renal fibrosis (biomarker_via_orthology)	SERPINE1 MMP9	4.48e-04	12	78	2	DOID:0050855 (biomarker_via_orthology)
Disease	focal segmental glomerulosclerosis (biomarker_via_orthology)	SERPINE1 MMP9	4.48e-04	12	78	2	DOID:1312 (biomarker_via_orthology)
Disease	pre-eclampsia (is_marker_for)	SERPINE1 MMP9 F2R	4.94e-04	58	78	3	DOID:10591 (is_marker_for)
Disease	thoracic aortic aneurysm (is_marker_for)	SERPINE1 MMP9	6.15e-04	14	78	2	DOID:14004 (is_marker_for)
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	PDXDC1 MYO3A FLT4 ALAD	6.50e-04	148	78	4	C0279702
Disease	relapsing-remitting multiple sclerosis (is_marker_for)	SERPINE1 MMP9	7.08e-04	15	78	2	DOID:2378 (is_marker_for)
Disease	thrombosis (is_implicated_in)	SERPINE1 MMP9	7.08e-04	15	78	2	DOID:0060903 (is_implicated_in)
Disease	level of Sphingomyelin (d32:1) in blood serum	NUP88 ERMP1	9.14e-04	17	78	2	OBA_2045173
Disease	Liver diseases	SERPINE1 ALAD MMP9	9.29e-04	72	78	3	C0023895
Disease	Liver Dysfunction	SERPINE1 ALAD MMP9	9.29e-04	72	78	3	C0086565
Disease	Prostatic Neoplasms	SERPINE1 PTRH2 NDST4 ALAD MMP9 DEGS1 MED12	1.23e-03	616	78	7	C0033578
Disease	Malignant neoplasm of prostate	SERPINE1 PTRH2 NDST4 ALAD MMP9 DEGS1 MED12	1.23e-03	616	78	7	C0376358
Disease	pulmonary hypertension (biomarker_via_orthology)	MMP9 RYR2 RYR3	1.26e-03	80	78	3	DOID:6432 (biomarker_via_orthology)
Disease	glaucoma (is_marker_for)	SERPINE1 MMP9	1.27e-03	20	78	2	DOID:1686 (is_marker_for)
Disease	lung disease (is_marker_for)	SERPINE1 MMP9	1.54e-03	22	78	2	DOID:850 (is_marker_for)
Disease	nevus count, cutaneous melanoma	DOCK8 ATP11A HERC2	1.83e-03	91	78	3	EFO_0000389, EFO_0004632
Disease	adult respiratory distress syndrome (is_marker_for)	SERPINE1 MMP9	2.15e-03	26	78	2	DOID:11394 (is_marker_for)
Disease	macular degeneration (is_marker_for)	SERPINE1 MMP9	2.15e-03	26	78	2	DOID:4448 (is_marker_for)
Disease	chronic obstructive pulmonary disease (biomarker_via_orthology)	SERPINE1 MMP9	2.49e-03	28	78	2	DOID:3083 (biomarker_via_orthology)
Disease	obesity (implicated_via_orthology)	TBC1D5 DEGS1 MED12 ITPR3	2.57e-03	215	78	4	DOID:9970 (implicated_via_orthology)
Disease	suntan	DENND1B ATP11A HERC2	2.60e-03	103	78	3	EFO_0004279

Protein segments in the cluster

Peptide	Gene	Start	Entry
AALVAAHSAYLSPMA	CELF3	216	Q5SZQ8
LRAFLMPIHVYSGIV	CYBRD1	151	Q53TN4
LLVHSSRGPAHYEML	C1QL4	11	Q86Z23
TSGRPFLLYVALAHM	ARSG	236	Q96EG1
LSMDGTLHTPAILLY	CYB5D1	206	Q6P9G0
PEGMVTVAIAAHYLS	ERMP1	856	Q7Z2K6
HLTMHDYAPLVSGAL	ITPR3	1061	Q14573
MTLLASFLYSAHLPE	PAQR5	226	Q9NXK6
PMISDDLVNSYHLLL	RBL2	216	Q08999
EMDLGAIPDLLHLAY	RAB3GAP2	986	Q9H2M9
ALGLDHSSVPEALMY	MMP9	406	P14780
SGPLILTHIYLLLGM	DOLK	401	Q9UPQ8
HEYTMTLGLPEFIRA	NRAP	1246	Q86VF7
HSSMEQDVGLLRLYP	ASPG	231	Q86U10
LPLAVYHVSGEFAML	ALAD	271	P13716
LLLGLHASYLAMSTP	HERC2	1311	O95714
LIFLIYLDAGLHTPM	OR2V1	46	Q8NHB1
ILASLLDSQLHTPMY	OR2W1	46	Q9Y3N9
ILMLPLSLIATSYGH	OR2Z1	206	Q8NG97
SLHEPLYIFLGMLGA	OR52A1	56	Q9UKL2
PADTLATYLLMLEGH	PDE4C	366	Q08493
YLLMGHSDVVNILSP	PGLYRP3	311	Q96LB9
MALLGHSLGAYISTL	PDXDC1	91	Q6P996
LGSLMKTPDLEILHY	PRAMEF18	66	Q5VWM3
YNPISTIEGSMLHEL	LINGO1	296	Q96FE5
ITSFALGMSYHLPLV	MED12	856	Q93074
QITAPASMLIGDHYL	DPP4	286	P27487
FIELPYHGESISMLI	SERPINE2	241	P07093
YHGESISMLIALPTE	SERPINE2	246	P07093
MIHELLLALSGYPGS	TUBGCP4	1	Q9UGJ1
LDALHDHLATIYPGM	GUCY1B1	101	Q02153
MLVLYGHSTQDLPET	CELA1	1	Q9UNI1
GTTALYLFLLMHPSI	NDST4	606	Q9H3R1
LTHLIGSPFLRAYMH	NOL10	386	Q9BSC4
GLISLDSRLHAPMYF	OR2A7	46	Q96R45
HARPMYIFLGVLSVI	OR10G3	56	Q8NGC4
LHGPAMVKYLLLSIL	IL17F	6	Q96PD4
YLMDAASLLPVLALG	NSUN4	156	Q96CB9
GLISLDSRLHAPMYF	OR2A4	46	O95047
PAVVYMLHLATADVL	F2R	136	P25116
ESPSHLYLAMELVTG	PNCK	81	Q6P2M8
ELLYTDATVIPHLMA	ARMC8	141	Q8IUR7
LHSLALIVDSSGPMY	HEATR5B	956	Q9P2D3
PSSLMLLNTAHEYLG	CABIN1	886	Q9Y6J0
LSMLEDHSYLPVGSV	DOCK8	1676	Q8NF50
VLIHLLMLESGYIPQ	FBXO7	201	Q9Y3I1
ESLMLVTALNPHIGY	FH	451	P07954
YMLAASLLGLGLHPI	DEGS1	211	O15121
YITGLAEHLSPLMLS	GAA	256	P10253
QLLVMLPDSLHYSGV	ITGA7	756	Q13683
PLYISVGHRMSLEAA	ENDOV	206	Q8N8Q3
MPYLIGIHSSLIERV	DENND1B	261	Q6P3S1
FVYLADLLMPHLGAA	SLC39A11	91	Q8N1S5
GYMEPTLRILAILHT	RYR2	4566	Q92736
ILELPYHGDTLSMFI	SERPINE1	246	P05121
PNILVIATESGMLYH	NUP88	321	Q99567
HIPMYIFLSNLALTD	OR1Q1	56	Q15612
VFPHRSLLYVMGVLS	MROH5	216	Q6ZUA9
LLYHEPRSFEVGMLV	PWWP3A	401	Q2TAK8
LVLHAYMDELSFLSP	RSBN1	371	Q5VWQ0
TLAHLLPAPAMYSLL	SOX3	66	P41225
IFILPLMHTYAGLAV	SLC16A14	396	Q7RTX9
LGSLMKTPDLEILHY	PRAMEF19	66	Q5SWL8
IGIIAYMLLTHTSPF	STK17B	221	O94768
LLADELITVYSLPGM	SH3GLB2	356	Q9NR46
HLDIAPRYASILMGI	SLC17A7	426	Q9P2U7
LGLLLGLHASYLAMS	HERC2P3	36	Q9BVR0
IRPYLGDMTLSEIHA	SLC28A2	321	O43868
LTMLESPLEGISHYH	ANKRD20A12P	116	Q8NF67
SLPILLYSLMEQHVG	ATP11A	926	P98196
LVMEYLAHPSTLGLA	PTRH2	6	Q9Y3E5
IVDMLTYLVSHVPLG	TMEM45B	101	Q96B21
ALPLYHMSGSLLGIV	SLC27A3	326	Q5K4L6
GYMAPTLRALAIIHT	RYR3	4471	Q15413
MLVSTPLLHDALYLQ	FLT4	191	P35916
LDIYSASGMPLASLL	VPS16	66	Q9H269
YAAHDVTFIPLLMTL	ACP6	331	Q9NPH0
DHSMHSALPLGIYLA	ZDHHC17	351	Q8IUH5
RLLYMLAEALPVSHG	XPOT	451	O43592
PLHSLGHLIMDQSYV	PIEZO1	411	Q92508
LLMHYPFIGDVHSLI	TBC1D5	391	Q92609
GSLLLYLAVSLMDPG	ZDHHC12	56	Q96GR4
FSPKLLYEGMHLLIT	PIGG	951	Q5H8A4
RMSEPLIAYILHEAL	MYO3A	121	Q8NEV4
DHYVLPGMTLSLAER	NAT8L	271	Q8N9F0