Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionlysine-acetylated histone binding

MLLT1 BRD2 BRDT BRD4

1.64e-0730334GO:0070577
GeneOntologyMolecularFunctionacetylation-dependent protein binding

MLLT1 BRD2 BRDT BRD4

1.88e-0731334GO:0140033
GeneOntologyMolecularFunctionhistone binding

NAP1L3 MLLT1 CHD8 BRD2 BRDT BRD4 CBX2

2.13e-07265337GO:0042393
GeneOntologyMolecularFunctionmodification-dependent protein binding

MLLT1 CHD8 BRD2 BRDT BRD4 CBX2

9.84e-07206336GO:0140030
GeneOntologyMolecularFunctionP-TEFb complex binding

JMJD6 BRD4

1.59e-054332GO:0106140
GeneOntologyMolecularFunctionRNA polymerase core enzyme binding

RTF1 BRD4 RPAP2

5.57e-0545333GO:0043175
GeneOntologyMolecularFunctionRNA polymerase II C-terminal domain binding

RTF1 BRD4

1.44e-0411332GO:0099122
GeneOntologyMolecularFunctionRNA polymerase binding

RTF1 BRD4 RPAP2

1.68e-0465333GO:0070063
GeneOntologyMolecularFunctionRNA polymerase II CTD heptapeptide repeat modifying activity

BRD4 RPAP2

6.56e-0423332GO:0140994
GeneOntologyMolecularFunctioncyclosporin A binding

PPIG NKTR

7.15e-0424332GO:0016018
GeneOntologyMolecularFunctionhistone reader activity

BRDT BRD4

8.40e-0426332GO:0140566
GeneOntologyMolecularFunctionbeta-catenin binding

SETD1A CHD8 KANK1

1.01e-03120333GO:0008013
GeneOntologyMolecularFunctionchromatin binding

NAP1L3 MLLT1 CHD8 BRD2 BRD4 CBX2

1.19e-03739336GO:0003682
GeneOntologyMolecularFunctionhistone demethylase activity

FBXL19 JMJD6

1.20e-0331332GO:0032452
GeneOntologyMolecularFunctionprotein demethylase activity

FBXL19 JMJD6

1.27e-0332332GO:0140457
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

CHD9 CHD8

1.70e-0337332GO:0140658
GeneOntologyMolecularFunctionRNA polymerase II complex binding

RTF1 BRD4

1.89e-0339332GO:0000993
GeneOntologyMolecularFunctionchromatin-protein adaptor activity

BRDT BRD4

2.09e-0341332GO:0140463
GeneOntologyMolecularFunctiondemethylase activity

FBXL19 JMJD6

2.40e-0344332GO:0032451
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

PPIG NKTR

3.09e-0350332GO:0003755
GeneOntologyMolecularFunctioncis-trans isomerase activity

PPIG NKTR

3.46e-0353332GO:0016859
GeneOntologyMolecularFunctionbasal RNA polymerase II transcription machinery binding

RTF1 BRD4

5.32e-0366332GO:0001099
GeneOntologyMolecularFunctionbasal transcription machinery binding

RTF1 BRD4

5.32e-0366332GO:0001098
GeneOntologyMolecularFunctionhistone modifying activity

SETD1A FBXL19 JMJD6

6.30e-03229333GO:0140993
GeneOntologyMolecularFunctionp53 binding

CHD8 BRD4

7.17e-0377332GO:0002039
GeneOntologyMolecularFunctionmethylated histone binding

CHD8 CBX2

8.88e-0386332GO:0035064
GeneOntologyMolecularFunctionmethylation-dependent protein binding

CHD8 CBX2

9.28e-0388332GO:0140034
GeneOntologyMolecularFunctiontranscription coregulator activity

FBXL19 BRDT SPEN BRD4

1.33e-02562334GO:0003712
GeneOntologyBiologicalProcesschromatin organization

RTF1 NAP1L3 SETD1A CHD9 CHD8 FBXL19 BRD2 BRDT JMJD6 BAZ2B BRD4 CBX2

6.40e-098963312GO:0006325
GeneOntologyBiologicalProcessprotein-DNA complex organization

RTF1 NAP1L3 SETD1A CHD9 CHD8 FBXL19 BRD2 BRDT JMJD6 BAZ2B BRD4 CBX2

2.15e-089993312GO:0071824
GeneOntologyBiologicalProcesschromatin remodeling

NAP1L3 SETD1A CHD9 CHD8 FBXL19 BRD2 BRDT JMJD6 BAZ2B BRD4

1.47e-077413310GO:0006338
GeneOntologyBiologicalProcesspositive regulation of T-helper 17 cell lineage commitment

BRD2 BRD4

6.91e-058332GO:2000330
GeneOntologyBiologicalProcessregulation of T-helper 17 cell lineage commitment

BRD2 BRD4

1.35e-0411332GO:2000328
GeneOntologyBiologicalProcesspositive regulation of T-helper 17 cell differentiation

BRD2 BRD4

2.23e-0414332GO:2000321
GeneOntologyBiologicalProcesspositive regulation of cell fate commitment

BRD2 BRD4

3.74e-0418332GO:0010455
GeneOntologyCellularComponenttranscription elongation factor complex

RTF1 MLLT1 AFF1 BRD4 AFF4 AFF3

2.94e-1056336GO:0008023
GeneOntologyCellularComponentsuper elongation complex

AFF1 AFF4 AFF3

7.15e-086333GO:0032783
GeneOntologyCellularComponentnuclear protein-containing complex

RTF1 MLLT1 AFF1 SETD1A CHD8 CWC22 BRD4 AFF4 AFF3 CBX2

3.40e-0513773310GO:0140513
GeneOntologyCellularComponentchromatin

NAP1L3 SOX4 SETD1A CHD8 BRD2 BRDT BAZ2B BRD4 AFF4 CBX2

6.29e-0514803310GO:0000785
GeneOntologyCellularComponenteuchromatin

SETD1A AFF4 CBX2

1.98e-0472333GO:0000791
GeneOntologyCellularComponenttransferase complex

RTF1 SETD1A CHD8 FBXL19 DCAF5 BRD4 CBX2

6.43e-04963337GO:1990234
GeneOntologyCellularComponentnuclear body

SETD1A PPIG BRD2 CWC22 RNF111 AFF3

2.60e-03903336GO:0016604
GeneOntologyCellularComponentnuclear speck

SETD1A PPIG BRD2 CWC22

4.54e-03431334GO:0016607
GeneOntologyCellularComponenthistone methyltransferase complex

SETD1A CHD8

6.24e-0375332GO:0035097
DomainTF_AF4/FMR2

AFF1 AFF4 AFF3

1.83e-084323IPR007797
DomainBET

BRD2 BRDT BRD4

1.83e-084323PF17035
DomainNET_dom

BRD2 BRDT BRD4

1.83e-084323IPR027353
DomainNET

BRD2 BRDT BRD4

1.83e-084323PS51525
DomainAF-4

AFF1 AFF4 AFF3

1.83e-084323PF05110
DomainBromodomain_CS

BRD2 BRDT BAZ2B BRD4

1.03e-0726324IPR018359
DomainBROMODOMAIN_1

BRD2 BRDT BAZ2B BRD4

4.50e-0737324PS00633
DomainBromodomain

BRD2 BRDT BAZ2B BRD4

5.03e-0738324PF00439
DomainBROMODOMAIN_2

BRD2 BRDT BAZ2B BRD4

6.87e-0741324PS50014
DomainBROMO

BRD2 BRDT BAZ2B BRD4

7.59e-0742324SM00297
DomainBromodomain

BRD2 BRDT BAZ2B BRD4

7.59e-0742324IPR001487
Domain-

BRD2 BRDT BAZ2B BRD4

7.59e-07423241.20.920.10
DomainBRD4_CDT

BRDT BRD4

2.84e-062322PF17105
DomainBRD4_CDT

BRDT BRD4

2.84e-062322IPR031354
DomainChromo_domain

CHD9 CHD8 CBX2

9.02e-0624323IPR023780
DomainChromo

CHD9 CHD8 CBX2

1.16e-0526323PF00385
DomainCHROMO_2

CHD9 CHD8 CBX2

1.45e-0528323PS50013
DomainCHROMO_1

CHD9 CHD8 CBX2

1.45e-0528323PS00598
DomainChromodomain-like

CHD9 CHD8 CBX2

2.19e-0532323IPR016197
DomainCHROMO

CHD9 CHD8 CBX2

2.41e-0533323SM00298
DomainChromo/shadow_dom

CHD9 CHD8 CBX2

2.41e-0533323IPR000953
DomainBRK

CHD9 CHD8

4.25e-056322SM00592
DomainBRK_domain

CHD9 CHD8

4.25e-056322IPR006576
DomainBRK

CHD9 CHD8

4.25e-056322PF07533
DomainCyclophilin-type_PPIase_CS

PPIG NKTR

4.78e-0419322IPR020892
DomainCyclophilin-type_PPIase

PPIG NKTR

5.85e-0421322IPR024936
DomainPro_isomerase

PPIG NKTR

6.43e-0422322PF00160
Domain-

PPIG NKTR

6.43e-04223222.40.100.10
DomainCyclophilin-type_PPIase_dom

PPIG NKTR

6.43e-0422322IPR002130
DomainCyclophilin-like_dom

PPIG NKTR

6.43e-0422322IPR029000
DomainCSA_PPIASE_1

PPIG NKTR

6.43e-0422322PS00170
DomainCSA_PPIASE_2

PPIG NKTR

6.43e-0422322PS50072
DomainSNF2_N

CHD9 CHD8

1.37e-0332322PF00176
DomainSNF2_N

CHD9 CHD8

1.37e-0332322IPR000330
DomainZnf_FYVE_PHD

FBXL19 RPH3AL BAZ2B

2.00e-03147323IPR011011
DomainHMG_box

SOX4 MEIOSIN

3.71e-0353322PF00505
DomainHMG_BOX_2

SOX4 MEIOSIN

3.85e-0354322PS50118
DomainHMG

SOX4 MEIOSIN

3.85e-0354322SM00398
Domain-

SOX4 MEIOSIN

3.99e-03553221.10.30.10
DomainHMG_box_dom

SOX4 MEIOSIN

5.53e-0365322IPR009071
Domain-

FBXL19 RPH3AL BAZ2B RNF111

6.96e-034493243.30.40.10
DomainZnf_RING/FYVE/PHD

FBXL19 RPH3AL BAZ2B RNF111

7.51e-03459324IPR013083
DomainZnf_PHD-finger

FBXL19 BAZ2B

8.07e-0379322IPR019787
DomainPHD

FBXL19 BAZ2B

1.01e-0289322SM00249
DomainZnf_PHD

FBXL19 BAZ2B

1.06e-0291322IPR001965
DomainZF_PHD_2

FBXL19 BAZ2B

1.15e-0295322PS50016
DomainZF_PHD_1

FBXL19 BAZ2B

1.17e-0296322PS01359
DomainHelicase_C

CHD9 CHD8

1.44e-02107322PF00271
PathwayREACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX

RTF1 MLLT1 AFF4

1.26e-0458243M805
PathwayREACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS

RTF1 MLLT1 AFF4

3.39e-0481243M865
PathwayKEGG_MEDICUS_VARIANT_MLL_AF4_FUSION_TO_TRANSCRIPTIONAL_ACTIVATION

MLLT1 AFF1

8.81e-0426242M47439
Pubmed

AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.

MLLT1 AFF1 BRD4 AFF4

2.21e-101133424367103
Pubmed

MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.

MLLT1 AFF1 AFF4 AFF3

6.68e-101433420854876
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

MLLT1 CHD9 BRD2 BAZ2B BRD4 AFF4 AFF3

1.46e-0922233737071664
Pubmed

Lost in transcription: molecular mechanisms that control HIV latency.

MLLT1 AFF1 BRD4 AFF4

2.58e-091933423518577
Pubmed

Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice.

AFF1 AFF4 AFF3

3.11e-09433311923441
Pubmed

Expression of BET genes in testis of men with different spermatogenic impairments.

BRD2 BRDT BRD4

3.11e-09433322035730
Pubmed

A Minor Subset of Super Elongation Complexes Plays a Predominant Role in Reversing HIV-1 Latency.

AFF1 BRD4 AFF4

3.11e-09433326830226
Pubmed

Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4.

MLLT1 AFF1 AFF4

3.11e-09433325282333
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

MLLT1 CHD9 CHD8 BRD2 BRDT JMJD6 DCAF5 BRD4 AFF4 NAF1 RPAP2

3.58e-091116331131753913
Pubmed

Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.

PPIG KANK1 CWC22 DCAF5 AFF4 NAF1

7.41e-0915633622952844
Pubmed

The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin.

MLLT1 AFF1 AFF4

2.72e-08733315856011
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

CHD9 CHD8 BRD2 BRDT CWC22 JMJD6 BRD4 NAF1

2.86e-0853333830554943
Pubmed

Characterization of the DOT1L network: implications of diverse roles for DOT1L.

MLLT1 AFF1 AFF4 AFF3

6.63e-084133420431927
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

CHD9 CHD8 BRD2 SPEN BAZ2B BRD4 AFF4 CBX2

7.87e-0860833836089195
Pubmed

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.

MLLT1 AFF1 AFF4

9.30e-081033320153263
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

SETD1A CHD8 PPIG BRD2 SPEN CWC22

1.25e-0725133631076518
Pubmed

HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP.

MLLT1 AFF1 AFF4

1.28e-071133320471949
Pubmed

The little elongation complex regulates small nuclear RNA transcription.

MLLT1 AFF1 AFF4

1.70e-071233322195968
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

MLLT1 CHD8 BRD2 SPEN CWC22 BAZ2B BRD4 AFF4 CBX2

1.81e-0795433936373674
Pubmed

Transcriptional and posttranscriptional regulation of HIV-1 gene expression.

MLLT1 AFF1 AFF4

2.21e-071333322355797
Pubmed

Transcriptional elongation factor ENL phosphorylated by ATM recruits polycomb and switches off transcription for DSB repair.

MLLT1 AFF1 AFF4

2.81e-071433325921070
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SOX4 MLLT1 SETD1A CHD8 FBXL19 BRD2 SPEN BRD4 CBX2

6.19e-07110533935748872
Pubmed

The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.

MLLT1 AFF1 BRD4

6.29e-071833321030982
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

SOX4 FBXL19 BRD2 BRDT PRICKLE3 JMJD6 BRD4 CBX2

6.81e-0780833820412781
Pubmed

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

BRD2 BRDT BAZ2B BRD4

7.78e-077533425593309
Pubmed

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.

RTF1 CHD9 BRD2 SPEN JMJD6

8.04e-0718333536129980
Pubmed

Brd4-Brd2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specification.

BRD2 BRD4

8.73e-07233228588073
Pubmed

BET bromodomain proteins mediate downstream signaling events following growth factor stimulation in human lung fibroblasts and are involved in bleomycin-induced pulmonary fibrosis.

BRD2 BRD4

8.73e-07233223115324
Pubmed

Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription.

AFF1 AFF4

8.73e-07233226007649
Pubmed

Bromodomain and extra-terminal domain bromodomain inhibition prevents synovial inflammation via blocking IκB kinase-dependent NF-κB activation in rheumatoid fibroblast-like synoviocytes.

BRD2 BRD4

8.73e-07233226324948
Pubmed

Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation.

BRD2 BRD4

8.73e-07233232151278
Pubmed

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.

MLLT1 BRD4

8.73e-07233221964340
Pubmed

Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.

BRDT BRD4

8.73e-07233233637650
Pubmed

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.

BRD2 BRD4

8.73e-07233223255218
Pubmed

Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes.

BRD2 BRD4

8.73e-07233216940503
Pubmed

A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins.

BRD2 BRD4

8.73e-07233224146614
Pubmed

WHAT do viruses BET on?

BRD2 BRD4

8.73e-07233220036832
Pubmed

Distinct roles of two SEC scaffold proteins, AFF1 and AFF4, in regulating RNA polymerase II transcription elongation.

AFF1 AFF4

8.73e-07233237528066
Pubmed

SARS-CoV-2 E protein interacts with BRD2 and BRD4 SEED domains and alters transcription in a different way than BET inhibition.

BRD2 BRD4

8.73e-07233239066826
Pubmed

AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter.

AFF1 AFF4

8.73e-07233224843025
Pubmed

Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2.

BRD2 BRD4

8.73e-07233235839775
Pubmed

Association of AFF1 rs340630 and AFF3 rs10865035 polymorphisms with systemic lupus erythematosus in a Chinese population.

AFF1 AFF3

8.73e-07233222983539
Pubmed

In vitro nuclear interactome of the HIV-1 Tat protein.

SOX4 SETD1A CHD8 BRD2 SPEN

1.10e-0619533519454010
Pubmed

Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia.

AFF1 AFF4 AFF3

1.18e-062233316024815
Pubmed

The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency.

MLLT1 AFF1 AFF4

1.18e-062233322567366
Pubmed

New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).

MLLT1 BRD4 AFF4

1.36e-062333321360054
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

RTF1 MLLT1 AFF1 NKTR BRD2 AFF4 RNF111 AFF3

1.66e-0691033836736316
Pubmed

JMJD6-BRD4 complex stimulates lncRNA HOTAIR transcription by binding to the promoter region of HOTAIR and induces radioresistance in liver cancer stem cells.

JMJD6 BRD4

2.62e-06333237880710
Pubmed

Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the molecular pathology of FRAXE intellectual disability.

AFF4 AFF3

2.62e-06333221330300
Pubmed

Metabolically Derived Lysine Acylations and Neighboring Modifications Tune the Binding of the BET Bromodomains to Histone H4.

BRD2 BRDT

2.62e-06333228945351
Pubmed

Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors.

BRD2 BRD4

2.62e-06333225049379
Pubmed

Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited.

MLLT1 AFF1

2.62e-06333216433901
Pubmed

Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration.

BRD2 BRD4

2.62e-06333224049186
Pubmed

AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23).

AFF1 AFF4

2.62e-06333210588740
Pubmed

Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system.

BRD2 BRD4

2.62e-06333231792058
Pubmed

NF-κB signaling activation via increases in BRD2 and BRD4 confers resistance to the bromodomain inhibitor I-BET151 in U937 cells.

BRD2 BRD4

2.62e-06333230300821
Pubmed

Characterization of BRD4 during mammalian postmeiotic sperm development.

BRDT BRD4

2.62e-06333225691659
Pubmed

BET Proteins Exhibit Transcriptional and Functional Opposition in the Epithelial-to-Mesenchymal Transition.

BRD2 BRD4

2.62e-06333229437854
Pubmed

Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.

BRD2 BRD4

2.62e-06333228262505
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

BRD2 SPEN CWC22 BRD4

2.78e-0610333432744500
Pubmed

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

MLLT1 AFF1 BRD2 AFF4 RNF111 AFF3

2.96e-0643233623455922
Pubmed

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.

CHD9 CHD8 SPEN CBX2

3.48e-0610933433554859
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

SETD1A CHD8 BRD2 ZCCHC10 SPEN BRD4

4.74e-0646933627634302
Pubmed

LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA.

BRD2 BRD4

5.23e-06433231504794
Pubmed

Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4.

JMJD6 BRD4

5.23e-06433229176719
Pubmed

Mediation of Af4 protein function in the cerebellum by Siah proteins.

AFF1 AFF4

5.23e-06433215459319
Pubmed

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors.

BRD2 BRD4

5.23e-06433222912406
Pubmed

Regulation of NO synthesis, local inflammation, and innate immunity to pathogens by BET family proteins.

BRD2 BRD4

5.23e-06433224248598
Pubmed

HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold.

MLLT1 AFF4

5.23e-06433223251033
Pubmed

Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.

SETD1A KANK1 PRICKLE3 CWC22 NAF1

5.40e-0627033524366813
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

CHD9 CHD8 SPEN BAZ2B CBX2

6.67e-0628233523667531
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

RTF1 CHD8 SPEN BRD4 AFF4

6.78e-0628333530585729
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

AFF1 PPIG BRD2 SPEN PRICKLE3 BRD4 NAF1

6.79e-0677433715302935
Pubmed

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

SETD1A CHD8 SPEN BRD4

7.90e-0613433425452129
Pubmed

Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression.

BRD2 BRD4

8.72e-06533224733848
Pubmed

NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.

CHD8 BRD4

8.72e-06533226626481
Pubmed

Intron 1-Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins.

BRD2 BRD4

1.31e-05633231444232
Pubmed

Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription.

BRDT BRD4

1.31e-05633217690245
Pubmed

Misguided transcriptional elongation causes mixed lineage leukemia.

MLLT1 AFF1

1.31e-05633219956800
Pubmed

The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

BRD2 JMJD6 BRD4

2.20e-055733321555454
Pubmed

BRD4 Promotes Gastric Cancer Progression and Metastasis through Acetylation-Dependent Stabilization of Snail.

BRD2 BRD4

2.44e-05833231311807
Pubmed

Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin.

MLLT1 AFF4

2.44e-05833221873227
Pubmed

Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2.

AFF1 AFF4

2.44e-05833232479599
Pubmed

The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription.

MLLT1 AFF4

2.44e-05833222483617
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

GPALPP1 SETD1A CHD8 PPIG NKTR ZCCHC10 CWC22 JMJD6

2.48e-05131833830463901
Pubmed

Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure.

AFF1 AFF4

3.13e-05933224565118
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

SETD1A CHD9 CHD8 BRD2 BRD4

3.33e-0539433527248496
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

RTF1 CHD9 CHD8 PPIG BRD2 JMJD6 BRD4

3.86e-05101433732416067
Pubmed

Genetic interaction mapping in mammalian cells using CRISPR interference.

RTF1 SETD1A CBX2

3.91e-056933328481362
Pubmed

Expression of Leukaemia associated transcription factor Af9/Mllt3 in the cerebral cortex of the mouse.

MLLT1 AFF1

3.91e-051033219000783
Pubmed

Analysis of the dynamics of limb transcriptomes during mouse development.

SOX4 AFF3

3.91e-051033221801425
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

CHD8 PPIG BRD2 BAZ2B BRD4

4.06e-0541133535182466
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

NKTR KANK1 DCAF5 NAF1 CBX2 RPAP2

4.15e-0568933636543142
Pubmed

The protein interaction landscape of the human CMGC kinase group.

RTF1 MLLT1 AFF1 PPIG AFF4 AFF3

4.36e-0569533623602568
Pubmed

Human transcription factor protein interaction networks.

SOX4 MLLT1 SETD1A CHD8 BRD2 SPEN DCAF5 CBX2

4.41e-05142933835140242
Pubmed

Human mediator subunit MED26 functions as a docking site for transcription elongation factors.

MLLT1 AFF1 AFF4

4.63e-057333321729782
Pubmed

Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.

BRD2 BRD4

4.78e-051133228805820
Pubmed

A conserved acetylation switch enables pharmacological control of tubby-like protein stability.

CHD9 JMJD6 DCAF5 NAF1

5.82e-0522333433187986
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

CHD9 PPIG BRD2 SPEN CWC22 BRD4 AFF4

5.82e-05108233738697112
Pubmed

BET proteins are essential for the specification and maintenance of the epiblast lineage in mouse preimplantation embryos.

BRD2 BRD4

6.77e-051333235264162
InteractionPLCD3 interactions

RTF1 GPALPP1 MLLT1 AFF1 SETD1A CHD9 CHD8 KANK1 FBXL19 BRD2 ZCCHC10 SPEN PRICKLE3 CWC22 DCAF5 BRD4 AFF4 NAF1

1.21e-321213218int:PLCD3
InteractionPIP4K2A interactions

RTF1 GPALPP1 MLLT1 AFF1 CHD9 CHD8 PPIG KANK1 BRD2 ZCCHC10 SPEN PRICKLE3 CWC22 JMJD6 BRD4 AFF4 NAF1 AFF3

7.01e-282163218int:PIP4K2A
InteractionCT45A5 interactions

NAP1L3 SETD1A CHD9 CHD8 KANK1 BRD2 SPEN CWC22 JMJD6 BRD4 AFF4 NAF1 RNF111

5.00e-24783213int:CT45A5
InteractionCAMKV interactions

GPALPP1 MLLT1 AFF1 CHD9 BRD2 ZCCHC10 SPEN PRICKLE3 CWC22 BRD4 AFF4 NAF1

1.87e-191183212int:CAMKV
InteractionNFKBIL1 interactions

NAP1L3 SETD1A CHD9 CHD8 PPIG BRD2 ZCCHC10 SPEN CWC22 JMJD6 AFF4

1.31e-18933211int:NFKBIL1
InteractionSYT2 interactions

RTF1 NAP1L3 MLLT1 SETD1A CHD9 KANK1 CWC22 JMJD6 DCAF5 AFF4 NAF1 AFF3

3.67e-181503212int:SYT2
InteractionEPB41L3 interactions

RTF1 MLLT1 AFF1 SETD1A CHD9 PPIG KANK1 ZCCHC10 PRICKLE3 CWC22 AFF4 NAF1

5.09e-152723212int:EPB41L3
InteractionSULF2 interactions

SETD1A CHD9 BRD2 ZCCHC10 SPEN CWC22 DCAF5 BRD4 NAF1

1.61e-13119329int:SULF2
InteractionEPB41L1 interactions

MLLT1 AFF1 SETD1A BRD2 ZCCHC10 PRICKLE3 CWC22 AFF4 NAF1

9.81e-12187329int:EPB41L1
InteractionDENND2D interactions

RTF1 MLLT1 FBXL19 BRD2 CWC22 AFF4

1.84e-1136326int:DENND2D
InteractionMDK interactions

SETD1A CHD9 PPIG BRD2 CWC22 AFF4 NAF1

9.29e-1191327int:MDK
InteractionDDX23 interactions

RTF1 GPALPP1 MLLT1 PPIG NKTR BRD2 BRDT CWC22 BRD4 AFF4 NAF1

1.03e-104803211int:DDX23
InteractionMED19 interactions

FBXL19 BRD2 BRDT JMJD6 BRD4 AFF4 RPAP2

2.75e-10106327int:MED19
InteractionMED26 interactions

MLLT1 AFF1 BRD2 ZCCHC10 BRD4 AFF4 RPAP2

2.94e-10107327int:MED26
InteractionEPB41L5 interactions

SETD1A CHD9 BRD2 ZCCHC10 PRICKLE3 CWC22 DCAF5 AFF4 NAF1

6.24e-10298329int:EPB41L5
InteractionNKAP interactions

CHD9 CHD8 PPIG NKTR BRD2 ZCCHC10 JMJD6

1.29e-09132327int:NKAP
InteractionPLCD4 interactions

NAP1L3 MLLT1 FBXL19 AFF4 CBX2

1.42e-0932325int:PLCD4
InteractionPOLR1G interactions

RTF1 MLLT1 CHD9 CHD8 BRD2 BAZ2B BRD4 AFF4 CBX2 RPAP2

2.58e-094893210int:POLR1G
InteractionDHX8 interactions

RTF1 GPALPP1 NKTR ZCCHC10 SPEN CWC22 JMJD6 AFF4

1.37e-08292328int:DHX8
InteractionKCNE3 interactions

NAP1L3 FBXL19 BRD2 SPEN PRICKLE3 BRD4 NAF1 CBX2

1.53e-08296328int:KCNE3
InteractionTAF7 interactions

CHD8 BRD2 ZCCHC10 BRDT JMJD6 BRD4

1.67e-08108326int:TAF7
InteractionCHD8 interactions

SETD1A CHD8 PPIG BRD2 BRDT BRD4 NAF1

1.82e-08193327int:CHD8
InteractionBRD9 interactions

BRD2 ZCCHC10 CWC22 JMJD6 BRD4 NAF1

2.70e-08117326int:BRD9
InteractionFAM9A interactions

NAP1L3 CWC22 JMJD6 AFF4 NAF1

3.43e-0859325int:FAM9A
InteractionCDK12 interactions

MLLT1 ZCCHC10 SPEN CWC22 BRD4 AFF4 RNF111

5.72e-08228327int:CDK12
InteractionDAXX interactions

SETD1A CHD9 BRD2 ZCCHC10 SPEN AFF4 NAF1 CBX2

5.97e-08353328int:DAXX
InteractionCACTIN interactions

BRD2 ZCCHC10 SPEN CWC22 JMJD6 BRD4

9.32e-08144326int:CACTIN
InteractionCSNK2A1 interactions

RTF1 MLLT1 SETD1A NKTR BRD2 ZCCHC10 JMJD6 BRD4 NAF1 RNF111 CBX2

1.33e-079563211int:CSNK2A1
InteractionPIP4K2C interactions

RTF1 BRD2 ZCCHC10 PRICKLE3 BRD4 AFF4

1.68e-07159326int:PIP4K2C
InteractionNKAPD1 interactions

GPALPP1 PPIG NKTR ZCCHC10 CWC22 JMJD6

1.81e-07161326int:NKAPD1
InteractionFGF12 interactions

RTF1 MLLT1 AFF1 CHD9 AFF4

2.45e-0787325int:FGF12
InteractionFGF11 interactions

RTF1 SETD1A CHD9 DCAF5 BRD4 RPAP2

2.49e-07170326int:FGF11
InteractionMED14 interactions

RTF1 FBXL19 ZCCHC10 JMJD6 BRD4 RPAP2

2.58e-07171326int:MED14
InteractionNUP43 interactions

RTF1 GPALPP1 SETD1A CHD9 CHD8 NKTR SPEN CWC22 BAZ2B

3.71e-07625329int:NUP43
InteractionGRK5 interactions

PPIG KANK1 CWC22 DCAF5 AFF4 NAF1

3.72e-07182326int:GRK5
InteractionPNN interactions

GPALPP1 PPIG NKTR BRD2 BRDT CWC22 BRD4

3.86e-07302327int:PNN
InteractionKMT2A interactions

RTF1 MLLT1 AFF1 SETD1A CHD8 BRD4 AFF4

5.02e-07314327int:KMT2A
InteractionJMJD6 interactions

PPIG BRD2 ZCCHC10 JMJD6 BRD4 NAF1

7.48e-07205326int:JMJD6
InteractionNSD3 interactions

SOX4 CHD8 BRD2 BRDT BRD4

1.08e-06117325int:NSD3
InteractionSP110 interactions

MLLT1 DCAF5 BRD4 AFF4 NAF1

1.32e-06122325int:SP110
InteractionMLLT1 interactions

MLLT1 AFF1 BRD4 AFF4 AFF3

1.38e-06123325int:MLLT1
InteractionC1orf226 interactions

BRD2 ZCCHC10 BRD4 NAF1

1.45e-0653324int:C1orf226
InteractionMED31 interactions

FBXL19 JMJD6 BRD4 NAF1 RPAP2

1.49e-06125325int:MED31
InteractionPPIG interactions

CHD8 PPIG ZCCHC10 JMJD6 BRD4

1.61e-06127325int:PPIG
InteractionCOIL interactions

RTF1 MLLT1 CHD9 CHD8 BRD2 ZCCHC10 BAZ2B AFF4

1.77e-06552328int:COIL
InteractionZNF816 interactions

GPALPP1 NKTR DCAF5

2.01e-0616323int:ZNF816
InteractionSLX4 interactions

MLLT1 CHD9 CHD8 BRD2 BAZ2B BRD4 AFF4 AFF3

2.31e-06572328int:SLX4
InteractionANKRD36B interactions

CHD9 CHD8 ZCCHC10 SPEN

2.40e-0660324int:ANKRD36B
InteractionNOVA2 interactions

BRD2 BRDT BRD4

2.44e-0617323int:NOVA2
InteractionPSME3 interactions

CHD8 FBXL19 RPH3AL ZCCHC10 BRD4 RNF111 CBX2

2.44e-06398327int:PSME3
InteractionCCNT2 interactions

MLLT1 BRDT BRD4 AFF4

2.74e-0662324int:CCNT2
InteractionPES1 interactions

SETD1A BRD2 CWC22 BRD4 AFF4 NAF1

2.85e-06258326int:PES1
InteractionPWWP2B interactions

BRD2 BRDT BRD4

2.92e-0618323int:PWWP2B
InteractionSNIP1 interactions

RTF1 GPALPP1 PPIG NKTR BRD2 ZCCHC10 CWC22

3.32e-06417327int:SNIP1
InteractionAFF1 interactions

MLLT1 AFF1 BRD4 AFF4

3.52e-0666324int:AFF1
InteractionBRD2 interactions

RTF1 CHD8 BRD2 BRDT JMJD6 BRD4 RNF111

4.01e-06429327int:BRD2
InteractionCSNK2B interactions

CHD8 NKTR BRD2 BRDT BAZ2B BRD4 RNF111 CBX2

4.45e-06625328int:CSNK2B
InteractionARRB2 interactions

RTF1 MLLT1 NKTR KANK1 BRD2 BRD4 AFF4

5.81e-06454327int:ARRB2
InteractionDDX41 interactions

BRD2 SPEN CWC22 JMJD6 BRD4

6.00e-06166325int:DDX41
InteractionTWIST1 interactions

CHD9 CHD8 SPEN BRD4 CBX2

6.74e-06170325int:TWIST1
InteractionH3C1 interactions

MLLT1 SETD1A CHD8 BRD2 SPEN JMJD6 BRD4 AFF4 CBX2

7.59e-06901329int:H3C1
InteractionBRDT interactions

CHD8 BRD2 BRDT BRD4

7.99e-0681324int:BRDT
InteractionELL3 interactions

MLLT1 AFF1 AFF4

9.22e-0626323int:ELL3
InteractionMED30 interactions

FBXL19 BRD2 BRD4 RPAP2

9.24e-0684324int:MED30
InteractionMLLT3 interactions

MLLT1 AFF1 AFF4 AFF3

9.68e-0685324int:MLLT3
InteractionMED22 interactions

BRD2 ZCCHC10 BRD4 RPAP2

9.68e-0685324int:MED22
InteractionTAF5 interactions

SOX4 BRD2 ZCCHC10 BRDT

1.01e-0586324int:TAF5
InteractionH3C3 interactions

CHD8 BRD2 SPEN BAZ2B BRD4 AFF4 CBX2

1.02e-05495327int:H3C3
InteractionPIP4K2B interactions

BRD2 ZCCHC10 PRICKLE3 BRD4

1.57e-0596324int:PIP4K2B
InteractionPOLR1E interactions

MLLT1 CHD8 BRD2 BAZ2B BRD4 RPAP2

1.63e-05350326int:POLR1E
InteractionH3-3A interactions

SETD1A CHD9 CHD8 BRD2 SPEN BRD4 AFF4 CBX2

1.67e-05749328int:H3-3A
InteractionSMC5 interactions

MLLT1 CHD8 BRD2 SPEN CWC22 BAZ2B BRD4 AFF4 CBX2

1.75e-051000329int:SMC5
InteractionMED6 interactions

FBXL19 ZCCHC10 BRD4 RPAP2

1.92e-05101324int:MED6
InteractionELL2 interactions

MLLT1 AFF1 AFF4

1.92e-0533323int:ELL2
InteractionMED29 interactions

FBXL19 BRD2 ZCCHC10 BRD4

1.99e-05102324int:MED29
InteractionMED27 interactions

FBXL19 ZCCHC10 BRD4 RPAP2

1.99e-05102324int:MED27
InteractionTERF2IP interactions

RTF1 SETD1A CHD8 SPEN BRD4 AFF4 CBX2

2.07e-05552327int:TERF2IP
InteractionCHST5 interactions

SETD1A CWC22 NAF1

2.10e-0534323int:CHST5
InteractionDACH1 interactions

SOX4 PPIG ZCCHC10 BRDT

2.15e-05104324int:DACH1
InteractionCCNT1 interactions

MLLT1 AFF1 BRDT BRD4 AFF4

2.61e-05225325int:CCNT1
InteractionH2BC8 interactions

RTF1 GPALPP1 CHD8 BRD2 SPEN BRD4 CBX2

2.72e-05576327int:H2BC8
InteractionHMGXB4 interactions

BRD2 ZCCHC10 JMJD6 BRD4

2.99e-05113324int:HMGXB4
InteractionEDA interactions

SETD1A CWC22 AFF4 NAF1

2.99e-05113324int:EDA
InteractionNOS1AP interactions

BRD2 ZCCHC10 BRD4 NAF1

2.99e-05113324int:NOS1AP
InteractionCTR9 interactions

RTF1 SOX4 BRD4 AFF4 NAF1

3.09e-05233325int:CTR9
InteractionVANGL1 interactions

FBXL19 BRD2 ZCCHC10 PRICKLE3 NAF1

3.15e-05234325int:VANGL1
InteractionTSPYL1 interactions

NAP1L3 BRD2 ZCCHC10 RNF111

3.31e-05116324int:TSPYL1
InteractionAPOC3 interactions

SOX4 BRD4 RPAP2

3.45e-0540323int:APOC3
InteractionH2BC3 interactions

SETD1A CHD9 CHD8 BRD2 BRD4 CBX2

3.75e-05406326int:H2BC3
InteractionMED8 interactions

FBXL19 ZCCHC10 BRD4 RPAP2

3.90e-05121324int:MED8
InteractionTAF6 interactions

SETD1A BRD2 ZCCHC10 BRDT BRD4

3.93e-05245325int:TAF6
InteractionDHX40 interactions

RTF1 BRD2 BRDT JMJD6 BRD4

4.24e-05249325int:DHX40
InteractionSTAC3 interactions

ZCCHC10 JMJD6 BAZ2B

4.30e-0543323int:STAC3
InteractionMAD2L1 interactions

SETD1A CHD9 CHD8 DCAF5 BRD4

4.49e-05252325int:MAD2L1
InteractionMED24 interactions

FBXL19 BRD2 BRD4 RPAP2

4.86e-05128324int:MED24
InteractionEAF1 interactions

MLLT1 AFF1 AFF4 NAF1

4.86e-05128324int:EAF1
InteractionSNRNP40 interactions

GPALPP1 NKTR SPEN CWC22 BAZ2B BRD4 CBX2

5.15e-05637327int:SNRNP40
InteractionMED15 interactions

RTF1 FBXL19 BRD4 RPAP2

5.32e-05131324int:MED15
InteractionCBX3 interactions

RTF1 SETD1A CHD9 CHD8 BRD2 SPEN BRD4

5.63e-05646327int:CBX3
InteractionPRPF40A interactions

PPIG ZCCHC10 SPEN CWC22 JMJD6 BRD4

6.32e-05446326int:PRPF40A
Cytoband1p22.1

BRDT RPAP2

2.45e-04323321p22.1
CytobandEnsembl 112 genes in cytogenetic band chr1p22

BRDT RPAP2

4.39e-03137332chr1p22
CytobandEnsembl 112 genes in cytogenetic band chr2q31

PPIG CWC22

7.29e-03178332chr2q31
Cytoband16p11.2

SETD1A FBXL19

8.35e-0319133216p11.2
GeneFamilyAF4/FMR2 family|Super elongation complex

MLLT1 AFF1 AFF4 AFF3

1.09e-1091941280
GeneFamilyAF4/FMR2 family|Super elongation complex

AFF1 AFF4 AFF3

3.93e-0941931145
GeneFamilyCyclophilin peptidylprolyl isomerases

PPIG NKTR

1.77e-0419192909
GeneFamilyPHD finger proteins

FBXL19 BAZ2B

3.97e-039019288
GeneFamilyRNA binding motif containing

SETD1A SPEN

2.07e-02213192725
CoexpressionMENON_FETAL_KIDNEY_0_CAP_MESENCHYME_CELLS

SOX4 NKTR SPEN BAZ2B

4.34e-0690324M39250
CoexpressionDAZARD_RESPONSE_TO_UV_NHEK_DN

AFF1 CHD9 KANK1 SPEN BAZ2B

2.97e-05300325M8702
CoexpressionGRESHOCK_CANCER_COPY_NUMBER_UP

MLLT1 AFF1 BRD4 AFF4 AFF3

4.22e-05323325M9150
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_CORRELATED_WITH_HAI_28DY_RESPONSE_AT_3DY_NEGATIVE

PPIG NKTR ZCCHC10 AFF4 AFF3

7.34e-05363325M41103
CoexpressionGSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_DN

NAP1L3 CHD9 KANK1 AFF3

9.44e-05197324M10015
CoexpressionGSE18281_SUBCAPSULAR_CORTICAL_REGION_VS_WHOLE_MEDULLA_THYMUS_UP

CHD8 BRD4 AFF4 CBX2

9.81e-05199324M7254
CoexpressionGSE41867_NAIVE_VS_DAY15_LCMV_EFFECTOR_CD8_TCELL_DN

AFF1 NKTR BRD4 AFF4

1.00e-04200324M9472
CoexpressionGSE17721_POLYIC_VS_CPG_6H_BMDC_UP

BRDT SPEN CWC22 CBX2

1.00e-04200324M3943
CoexpressionBUSSLINGER_DUODENAL_TUFT_CELLS

SOX4 CHD9 BRD4

1.32e-0481323M40033
CoexpressionCHEN_HOXA5_TARGETS_9HR_UP

CHD9 PPIG ZCCHC10 RNF111

1.52e-04223324M17621
CoexpressionAtlaskidney single cell_e11.5_MetanephMesench_StemCellamp_k-means-cluster#2_top-relative-expression-ranked_1000

SOX4 SETD1A CWC22 NAF1 RNF111

6.21e-06176325gudmap_kidney single cell_e11.5_MetanephMesench_Scamp_k2_1000
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_1000

SOX4 SETD1A CHD9 CHD8 NKTR BRD2 BAZ2B AFF3

1.86e-05801328gudmap_developingGonad_e14.5_ epididymis_1000
CoexpressionAtlasDevelopingGonad_e11.5_ovary + mesonephros_emap-3226_top-relative-expression-ranked_1000

NAP1L3 SOX4 SETD1A CHD9 CHD8 NKTR BRD2 JMJD6

2.11e-05815328gudmap_developingGonad_e11.5_ovary + mesonephros_1000
CoexpressionAtlasDevelopingGonad_e11.5_testes_emap-3226_top-relative-expression-ranked_1000

SOX4 MLLT1 CHD8 FBXL19 BRD2 JMJD6 BAZ2B CBX2

2.69e-05843328gudmap_developingGonad_e11.5_testes_1000
CoexpressionAtlasDevelopingGonad_e11.5_testes and mesonephros_emap-3226_top-relative-expression-ranked_1000

SOX4 MLLT1 CHD8 FBXL19 BRD2 JMJD6 BAZ2B CBX2

2.71e-05844328gudmap_developingGonad_e11.5_testes and mesonephros_1000
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_top-relative-expression-ranked_500

SOX4 SETD1A CHD9 CHD8 NKTR AFF3

2.72e-05404326gudmap_developingGonad_e18.5_epididymis_500
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_500

SOX4 SETD1A CHD9 CHD8 NKTR AFF3

2.80e-05406326gudmap_developingGonad_e16.5_epididymis_500
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#4_top-relative-expression-ranked_500

SETD1A CHD9 NKTR AFF3

7.76e-05152324gudmap_developingGonad_e18.5_epididymis_500_k4
CoexpressionAtlasDevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#2_top-relative-expression-ranked_1000

NAP1L3 SETD1A CHD9 CHD8 NKTR

1.13e-04323325gudmap_developingGonad_e11.5_ovary + mesonephros_k2_1000
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_1000

SOX4 SETD1A CHD9 CHD8 NKTR BRD2 AFF3

1.43e-04790327gudmap_developingGonad_e16.5_epididymis_1000
CoexpressionAtlasDevelopingGonad_P2_epididymis_emap-30199_top-relative-expression-ranked_1000

SOX4 SETD1A CHD9 CHD8 NKTR BRD2 AFF3

1.51e-04797327gudmap_developingGonad_P2_epididymis_1000
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_top-relative-expression-ranked_1000

SOX4 SETD1A CHD9 CHD8 NKTR BRD2 AFF3

1.54e-04799327gudmap_developingGonad_e18.5_epididymis_1000
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000

SOX4 SETD1A CHD9 CHD8 NKTR BRD2 BRDT

1.62e-04806327gudmap_developingGonad_e12.5_epididymis_1000
CoexpressionAtlasDevelopingGonad_e12.5_testes_emap-29069_top-relative-expression-ranked_1000

SOX4 MLLT1 CHD8 BRD2 JMJD6 BAZ2B CBX2

1.79e-04819327gudmap_developingGonad_e12.5_testes_1000
CoexpressionAtlasDevelopingGonad_e14.5_ testes_emap-6710_top-relative-expression-ranked_1000

SOX4 CHD8 BRD2 BRDT JMJD6 BAZ2B CBX2

1.83e-04822327gudmap_developingGonad_e14.5_ testes_1000
CoexpressionAtlasDevelopingGonad_e12.5_testes_emap-29069_top-relative-expression-ranked_500

SOX4 CHD8 BRD2 BAZ2B CBX2

3.28e-04406325gudmap_developingGonad_e12.5_testes_500
CoexpressionAtlasDevelopingGonad_e14.5_ testes_emap-6710_top-relative-expression-ranked_500

SOX4 BRD2 BRDT BAZ2B CBX2

3.47e-04411325gudmap_developingGonad_e14.5_ testes_500
CoexpressionAtlasDevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#3_top-relative-expression-ranked_1000

SETD1A CHD9 CHD8 NKTR

3.50e-04225324gudmap_developingGonad_e14.5_ ovary_1000_k3
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_500

SOX4 SETD1A CHD9 CHD8 NKTR

3.55e-04413325gudmap_developingGonad_e14.5_ epididymis_500
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_k-means-cluster#2_top-relative-expression-ranked_1000

SETD1A CHD9 CHD8 NKTR

3.80e-04230324gudmap_developingGonad_e16.5_ovary_1000_k2
CoexpressionAtlasDevelopingGonad_e11.5_testes and mesonephros_emap-3226_top-relative-expression-ranked_500

SOX4 MLLT1 BRD2 BAZ2B CBX2

4.50e-04435325gudmap_developingGonad_e11.5_testes and mesonephros_500
CoexpressionAtlasDevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#3_top-relative-expression-ranked_1000

SETD1A CHD9 NKTR AFF3

5.13e-04249324gudmap_developingGonad_P2_epididymis_1000_k3
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#2_top-relative-expression-ranked_500

SETD1A CHD8 NKTR

5.55e-04107323gudmap_developingGonad_e14.5_ epididymis_500_k2
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#3_top-relative-expression-ranked_1000

SETD1A CHD9 CHD8 NKTR

7.44e-04275324gudmap_developingGonad_e14.5_ epididymis_1000_k3
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#3_top-relative-expression-ranked_1000

SETD1A CHD9 NKTR AFF3

8.06e-04281324gudmap_developingGonad_e18.5_epididymis_1000_k3
CoexpressionAtlasDevelopingGonad_e11.5_testes_emap-3226_k-means-cluster#5_top-relative-expression-ranked_1000

SOX4 MLLT1 FBXL19 JMJD6 CBX2

8.30e-04498325gudmap_developingGonad_e11.5_testes_k5_1000
CoexpressionAtlasDevelopingGonad_e12.5_testes_emap-29069_k-means-cluster#1_top-relative-expression-ranked_1000

SOX4 MLLT1 JMJD6 BAZ2B CBX2

1.04e-03524325gudmap_developingGonad_e12.5_testes_k1_1000
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_1000

SETD1A CHD9 CHD8 NKTR BRD2 BRDT

1.06e-03795326gudmap_developingGonad_e16.5_ovary_1000
CoexpressionAtlasDevelopingGonad_e11.5_testes and mesonephros_emap-3226_k-means-cluster#5_top-relative-expression-ranked_1000

SOX4 MLLT1 FBXL19 JMJD6 CBX2

1.12e-03533325gudmap_developingGonad_e11.5_testes and mesonephros_k5_1000
CoexpressionAtlasfacebase_RNAseq_e10.5_MandArch_2500

SOX4 CHD9 PPIG CWC22 BRD4 TMEM40 NAF1 CBX2

1.20e-031468328facebase_RNAseq_e10.5_MandArch_2500
CoexpressionAtlasDevelopingGonad_P2_ovary_emap-30224_k-means-cluster#5_top-relative-expression-ranked_1000

SETD1A CHD8 NKTR

1.50e-03151323gudmap_developingGonad_P2_ovary_1000_k5
CoexpressionAtlasDevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#4_top-relative-expression-ranked_1000

SOX4 BRD2 JMJD6

1.65e-03156323gudmap_developingGonad_e11.5_ovary + mesonephros_k4_1000
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

SOX4 CHD9 CHD8 BAZ2B AFF4

2.28e-071833358f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCelldroplet-Tongue-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RTF1 SOX4 PPIG BRD2 BRD4

2.61e-07188335d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SOX4 NKTR BAZ2B AFF4

9.06e-061793346e965e424eebef50f0202cff75f458be395cfca1
ToppCellCOVID-19_Mild-NK_CD56bright|COVID-19_Mild / Disease condition and Cell class

SOX4 CHD9 BAZ2B AFF3

9.06e-0617933490e7a4af195aa2332b07a9f06cde63e72ff49255
ToppCellControl-NK_CD56bright|Control / Disease condition and Cell class

SOX4 CHD9 BAZ2B AFF3

1.22e-051933348b1e7a226a6057e1097c1525984127b54e823876
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

RTF1 PPIG JMJD6 BRD4

1.35e-0519833476d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

RTF1 PPIG BAZ2B BRD4

1.37e-05199334c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell(08)_Brush+PNEC-(2)_GFP_FOXI1|(08)_Brush+PNEC / shred by cell type by condition

RTF1 PPIG BRD4

1.44e-04138333817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal-Mesoderm|GW16 / Sample Type, Dataset, Time_group, and Cell type.

PRICKLE3 TMEM40 NAF1

1.47e-04139333d441c29852c28928ecb696b4b95e31b30c17116b
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SOX4 KANK1 TMEM40

1.84e-0415033370ac8ae4b1683fb17278a8e4606f2fa0b94988c0
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5|390C / Donor, Lineage, Cell class and subclass (all cells)

NAP1L3 FBXL19 PRICKLE3

2.03e-04155333afdd0aba0f3788c2fb916ffb453c5dd7cde2304c
ToppCellBAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KANK1 FBXL19 RPAP2

2.07e-041563335d9e1df70f2e9219f6b029be2e39297605d36726
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_dendritic|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NAP1L3 SOX4 CBX2

2.31e-04162333233011408f022647932c81ebab78f9813e3c6833
ToppCellfacs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KANK1 RPH3AL TMEM40

2.52e-04167333a4a795751644b22af616335379e64ae95175180c
ToppCell368C-Lymphocytic-NK_cells-NK_cell_E|368C / Donor, Lineage, Cell class and subclass (all cells)

SOX4 SPEN AFF3

2.61e-041693330d96c0b4fd26fbc0bf44ff7bed2936eebcc55b74
ToppCellMild/Remission-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SOX4 BAZ2B AFF3

2.80e-04173333694d02c4d2dc2de4b344544f9124fec40fcf7d8f
ToppCell3'_v3-blood-Mast-Mast_cells|blood / Manually curated celltypes from each tissue

AFF1 PRICKLE3 CBX2

2.95e-04176333b9da3deaf62622d47eb30b6be7548253eee95597
ToppCellsevere-Others-CD34+_GATA2+_cells|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

NAP1L3 SOX4 CBX2

3.09e-04179333dd789a1b7327d6f9ed5272f3eb54bd43f7ae8d78
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX4 KANK1 TMEM40

3.20e-041813334e81ec1580e9acb22c32c465eb46f83d1e9e424e
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX4 KANK1 TMEM40

3.20e-04181333ad30c01290fb98adbd0caed301a584761212c977
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX4 KANK1 TMEM40

3.20e-041813333a3268a4dff8ffcb79e09f46490e138c96f8d916
ToppCelldroplet-Spleen-nan-18m|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHD9 BAZ2B AFF4

3.25e-04182333eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCellBac-SEP-Myeloid-pDC|Bac-SEP / Disease, Lineage and Cell Type

SOX4 CHD9 AFF3

3.41e-041853333de50b2042f22b0fb62ff12c76d85cc67649a0bd
ToppCellBrain_organoid-organoid_Kanton_Nature|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.

CHD9 NKTR BAZ2B

3.41e-04185333857c7ca8493e91ef1d0078ddafd6082020f9b169
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

BRD2 JMJD6 NAF1

3.46e-0418633335f32fc2761435356c8f54b5bb2f026b8c070efe
ToppCelldroplet-Bladder-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RTF1 PPIG BRD2

3.52e-04187333663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCellhematopoetic_progenitors-CD34+_HSC|World / Lineage and Cell class

NAP1L3 SOX4 CBX2

3.63e-0418933351ff31c9cf5eff98ad01c0455dc4ae4908713575
ToppCellCOVID-19_Severe-HSPC|COVID-19_Severe / disease group, cell group and cell class

NAP1L3 SOX4 CBX2

3.63e-0418933396015439971e2e5b8d6294ca5a6b873c7774e925
ToppCellCOVID-19_Severe-HSPC|World / disease group, cell group and cell class

NAP1L3 SOX4 CBX2

3.63e-04189333555c0b13f1508b9e3712b36d77144e73e828bc76
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

AFF1 CHD9 AFF3

3.63e-04189333b13f315f617840eb5143a4e8a33a657c20365c21
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

NKTR SPEN RNF111

3.74e-041913339454f642c3621370fa23640b631301346b300950
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D122|Adult / Lineage, Cell type, age group and donor

KANK1 RPH3AL AFF3

3.80e-0419233306013a07e3a873b1d1c0451643c528593ac32a9c
ToppCellfacs-Skin-Telogen-3m|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFF1 KANK1 AFF4

3.92e-04194333ba10fc5929649bb994c3f1d2ce6ca3167fa9b11b
ToppCelldroplet-Marrow-nan-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX4 CHD9 AFF3

3.92e-041943338ef0b71fef5b84cfd04973f891215333e7035d1d
ToppCellfacs-Skin-Telogen|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFF1 KANK1 AFF4

3.92e-04194333bafecab8d48fc94ffd93f0d054b5f32c04b6b3f6
ToppCellfacs-Skin-Telogen-3m-Epithelial|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFF1 KANK1 AFF4

3.92e-041943334d7fc4d0a55abb3b645116d13a983bbedc55f70c
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX4 AFF1 AFF3

3.92e-041943333a1f95639d5f239f001bd67d4213e8938e7f299d
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

KANK1 RPH3AL AFF3

3.92e-0419433397534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX4 AFF1 AFF3

3.92e-0419433311709704079f24a730476572dc2f01e9d2226e2c
ToppCellMild/Remission-B_naive-8|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SOX4 BAZ2B AFF3

3.97e-041953330a3221e4d1fa31a35868bdda0f0cc873c233b407
ToppCellControl-B_naive-8|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SOX4 BAZ2B AFF3

4.03e-0419633354074da84000e4749ade8acc542f05a275bf829f
ToppCell10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-immature_B_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SOX4 BRD2 AFF3

4.03e-041963339a6e4eea19348a6e3379d3b872456ab6280cb74f
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-IPC/newborn|World / Primary Cells by Cluster

SOX4 CHD9 BAZ2B

4.03e-04196333721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38|World / Primary Cells by Cluster

SOX4 CHD9 BAZ2B

4.03e-0419633338da0751941adca650fe9b383d9f343153978eb5
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

RTF1 PPIG NKTR

4.09e-041973330fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

BRD2 JMJD6 NAF1

4.09e-04197333cd54e6ad175529327fa0372033016b3b978dd452
ToppCellControl-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SOX4 BAZ2B AFF3

4.09e-04197333925bf0d38e4ce279fa45f455546ebd199282c0df
ToppCell10x3'2.3-week_17-19-Lymphocytic_B|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SOX4 BRD2 AFF3

4.16e-041983335f465cf5c7493e32d9afe9e9d05757d0a95acc33
ToppCell10x3'2.3-week_17-19-Lymphocytic_B-B_lineage|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SOX4 BRD2 AFF3

4.16e-0419833377ce3fe1ab161c0faf8987e73a64ab61294b9255
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

SOX4 CHD9 BAZ2B

4.16e-04198333de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCell(05)_Secretory-(2)_GFP_FOXI1|(05)_Secretory / shred by cell type by condition

RTF1 PPIG BRD4

4.22e-04199333d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SOX4 MLLT1 CHD9

4.22e-04199333174f6013af6eafa577f84205a62927f2b367fda3
ToppCell10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-pre_B_progenitor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SOX4 BRD2 AFF3

4.22e-04199333dd94e42b62af7cbd69c472681d3c758552694ae2
ToppCell(04)_Interm._basal>secr.-(2)_GFP_FOXI1|(04)_Interm._basal>secr. / shred by cell type by condition

RTF1 PPIG BRD4

4.22e-0419933353ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCellCOVID-19-COVID-19_Severe-Others-HSPC|COVID-19_Severe / Disease, condition lineage and cell class

NAP1L3 SOX4 CBX2

4.22e-0419933325de67b6c9c8d6bb9a538e071a40ef865906c95d
ToppCellControl-Control-Others-HSPC|Control / Disease, condition lineage and cell class

NAP1L3 SOX4 CBX2

4.22e-04199333b71169be0d916b2ed139a3122d78bb154c71edb4
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

PPIG BAZ2B BRD4

4.22e-04199333fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

AFF1 BAZ2B AFF3

4.22e-0419933394b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellSepsis-Bac-SEP-Myeloid-pDC|Bac-SEP / Disease, condition lineage and cell class

SOX4 CHD9 AFF3

4.22e-041993337f6569de050262f3d8d9d41c0f0cc139de85c0cb
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

RTF1 PPIG BRD4

4.22e-04199333a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal|GW09 / Sample Type, Dataset, Time_group, and Cell type.

NAP1L3 SOX4 AFF3

4.28e-04200333e9eb348a66011d8aace4331f84690ae27cb0d061
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal-Cortical_neuron|GW10 / Sample Type, Dataset, Time_group, and Cell type.

NAP1L3 SOX4 AFF3

4.28e-04200333458fb0f40c1720f1cacedf78c40bd059692bfc62
DrugICI 182,780; Down 200; 1uM; MCF7; HT_HG-U133A_EA

SOX4 PPIG NKTR SPEN BRD4

5.34e-06177335985_DN
DrugAC1NRAEN

BRD2 BRDT BRD4

1.10e-0530333CID005287841
Drugnitrosocimetidine

CWC22 DSPP

2.03e-055332CID000052445
Drugthioglycerol

RPH3AL CWC22 RNF111

3.29e-0543333CID000007291
Drugfolpet

CWC22 DSPP

5.67e-058332CID000008607
Drugflubendazole

PPIG DSPP

5.67e-058332CID000035802
Drugteucrin A

PPIG SPEN

7.29e-059332CID000159529
DrugCaptopril [62571-86-2]; Down 200; 17.2uM; PC3; HT_HG-U133A

SOX4 PPIG NKTR SPEN

1.26e-041793344585_DN
DrugCamptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A

GPALPP1 CHD9 SPEN RNF111

1.35e-041823343887_DN
Drugstaurosporine; Down 200; 0.1uM; MCF7; HG-U133A

SOX4 JMJD6 BRD4 RNF111

1.41e-04184334423_DN
DrugSulfaphenazole [526-08-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A

SOX4 NKTR SPEN BRD4

1.44e-041853341673_DN
DrugRapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

SOX4 NKTR SPEN JMJD6

1.56e-041893341045_DN
Drugtestosterone enanthate

SOX4 CHD8 PPIG NKTR BRD2 SPEN

1.57e-04575336ctd:C004648
Drugdimethylthioarsinic acid

AFF1 AFF4

1.57e-0413332ctd:C547156
DrugPerphenazine [58-39-9]; Down 200; 10uM; PC3; HG-U133A

RTF1 PPIG NKTR KANK1

1.76e-041953341956_DN
DrugPantothenic acid calcium salt monohydrate [63409-48-3]; Up 200; 8uM; HL60; HT_HG-U133A

SOX4 SETD1A JMJD6 RPAP2

1.79e-041963341311_UP
DrugMidecamycin [35457-80-8]; Down 200; 5uM; MCF7; HT_HG-U133A

GPALPP1 BRD4 AFF4 RPAP2

1.83e-041973341526_DN
Drugmethyl p-tolyl sulfide

PPIG DSPP

1.83e-0414332CID000069334
DrugCaffeic acid [3331-39-5]; Down 200; 22.2uM; HL60; HT_HG-U133A

AFF1 PRICKLE3 DSPP AFF3

1.86e-041983343053_DN
Drugphenformin hydrochloride; Down 200; 10uM; MCF7; HG-U133A

SOX4 SETD1A SPEN TMEM40

1.86e-0419833421_DN
DrugCefixime [79350-37-1]; Down 200; 8.8uM; PC3; HT_HG-U133A

SOX4 CHD8 NKTR RPH3AL

1.86e-041983344567_DN
DrugSulfinpyrazone [57-96-5]; Up 200; 9.8uM; HL60; HG-U133A

SOX4 AFF1 NKTR TMEM40

1.86e-041983341574_UP
DrugPrenylamine lactate [69-43-2]; Down 200; 9.6uM; HL60; HG-U133A

RTF1 SOX4 CHD9 BAZ2B

1.90e-041993341737_DN
DrugHarpagoside [19210-12-9]; Down 200; 8uM; MCF7; HT_HG-U133A

RTF1 RPH3AL BRD4 AFF4

1.90e-041993347355_DN
DrugOxethazaine [126-27-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A

RTF1 SOX4 NKTR AFF4

1.90e-041993341484_DN
DrugCyproterone acetate [427-51-0]; Down 200; 9.6uM; MCF7; HT_HG-U133A

RTF1 GPALPP1 CHD9 PRICKLE3

1.90e-041993346806_DN
DrugDibucaine [85-79-0]; Down 200; 11.6uM; MCF7; HT_HG-U133A

GPALPP1 NKTR AFF4 RNF111

1.90e-041993341469_DN
DrugAmbroxol hydrochloride [23828-92-4]; Down 200; 9.6uM; MCF7; HT_HG-U133A

PRICKLE3 JMJD6 BAZ2B BRD4

1.94e-042003345319_DN
DrugAC1NOXKO

PPIG BRD2

2.11e-0415332CID005120672
DiseaseCHARGE syndrome (implicated_via_orthology)

CHD9 CHD8

2.38e-057322DOID:0050834 (implicated_via_orthology)
DiseaseFacies

CHD8 AFF4

5.10e-0510322C0282631
DiseaseIntellectual Disability

SOX4 SETD1A CHD8 BRD4 AFF3

1.12e-04447325C3714756
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

AFF1 AFF4 AFF3

2.01e-04105323DOID:9352 (implicated_via_orthology)
Diseasemelanoma (is_marker_for)

BRD2 BRD4

5.89e-0433322DOID:1909 (is_marker_for)
DiseaseMitral valve prolapse

MEIOSIN TMEM40

7.01e-0436322HP_0001634
Diseasemean platelet volume

AFF1 CHD9 PRICKLE3 CWC22 DCAF5 AFF3

7.05e-041020326EFO_0004584
DiseaseAdult Medulloblastoma

BRD2 BRD4

1.00e-0343322C0278876
DiseaseChildhood Medulloblastoma

BRD2 BRD4

1.00e-0343322C0278510
DiseaseMelanotic medulloblastoma

BRD2 BRD4

1.00e-0343322C1275668
DiseaseMedullomyoblastoma

BRD2 BRD4

1.00e-0343322C0205833
DiseaseDesmoplastic Medulloblastoma

BRD2 BRD4

1.00e-0343322C0751291
DiseaseCongenital Heart Defects

BRD4 AFF4

1.05e-0344322C0018798
DiseaseGastric Adenocarcinoma

BRD2 BRDT

1.10e-0345322C0278701
DiseaseSalivary Gland Neoplasms

SOX4 SPEN

1.19e-0347322C0036095
DiseaseMedulloblastoma

BRD2 BRD4

1.35e-0350322C0025149
Diseasecongenital heart disease (implicated_via_orthology)

CHD9 CHD8

2.55e-0369322DOID:1682 (implicated_via_orthology)
Diseaseserum gamma-glutamyl transferase measurement

AFF1 CHD9 FBXL19 ZCCHC10 DCAF5

2.83e-03914325EFO_0004532
DiseaseGlioblastoma

BRD2 BRD4

3.33e-0379322C0017636
Diseaseage of onset of asthma

AFF3 RPAP2

3.33e-0379322OBA_2001001
DiseaseGraves disease

SETD1A FBXL19

3.50e-0381322EFO_0004237
DiseaseGiant Cell Glioblastoma

BRD2 BRD4

3.76e-0384322C0334588
Diseasealpha fetoprotein measurement

AFF1 CHD9

5.28e-03100322EFO_0010583

Protein segments in the cluster

PeptideGeneStartEntry
SSSSSSDSESSSGSD

AFF3

421

P51826
SSSSSSSSSTDESED

CHD8

2086

Q9HCK8
SDSSSDSSSDSDSST

BRD4

486

O60885
ESSSSDLSSSDSSDS

BRDT

651

Q58F21
SSSNSDSDSGTSSDT

BAZ2B

241

Q9UIF8
KSDSSDSDSSDSSNS

DSPP

546

Q9NZW4
DSDSSDSSNSSDSSD

DSPP

551

Q9NZW4
DSSNSSDSSDSSDSD

DSPP

556

Q9NZW4
SDSSDSSDSDSSDSN

DSPP

561

Q9NZW4
SSDSDSSDSNSSSDS

DSPP

566

Q9NZW4
SSDSNSSSDSDSSDS

DSPP

571

Q9NZW4
SSSDSDSSDSDSSDS

DSPP

576

Q9NZW4
DSSDSDSSDSSDSDS

DSPP

581

Q9NZW4
DSSDSSDSDSSDSSN

DSPP

586

Q9NZW4
SDSDSSDSSNSSDSS

DSPP

591

Q9NZW4
SDSSNSSDSSDSSDS

DSPP

596

Q9NZW4
SSDSSDSSDSSDSSD

DSPP

601

Q9NZW4
DSSDSSDSSDSSDSS

DSPP

606

Q9NZW4
SDSSDSSDSSDSKSD

DSPP

611

Q9NZW4
SDSSDSDSKSDSSDS

DSPP

631

Q9NZW4
SDSKSDSSDSNSSDS

DSPP

636

Q9NZW4
DSSDSNSSDSSDNSD

DSPP

641

Q9NZW4
NSSDSSDNSDSSDSS

DSPP

646

Q9NZW4
SDNSDSSDSSNSSNS

DSPP

651

Q9NZW4
SSDSSNSSNSSDSSD

DSPP

656

Q9NZW4
NSSNSSDSSDSSDSS

DSPP

661

Q9NZW4
SDSSDSSDSSDSSSS

DSPP

666

Q9NZW4
SSDSSDSSSSSDSSN

DSPP

671

Q9NZW4
DSSSSSDSSNSSDSS

DSPP

676

Q9NZW4
SDSSNSSDSSDSSDS

DSPP

681

Q9NZW4
SSDSSDSSDSSNSSE

DSPP

686

Q9NZW4
DSSDSSNSSESSDSS

DSPP

691

Q9NZW4
SNSSESSDSSDSSDS

DSPP

696

Q9NZW4
SSDSSDSSDSDSSDS

DSPP

701

Q9NZW4
DSSDSDSSDSSDSSN

DSPP

706

Q9NZW4
DSSDSSDSSNSNSSD

DSPP

711

Q9NZW4
SDSSNSNSSDSDSSN

DSPP

716

Q9NZW4
SNSSDSDSSNSSDSS

DSPP

721

Q9NZW4
SDSSNSSDSSDSSNS

DSPP

726

Q9NZW4
SSDSSDSSNSSDSSD

DSPP

731

Q9NZW4
DSSNSSDSSDSSDSS

DSPP

736

Q9NZW4
SDSSDSSDSSNSSDS

DSPP

741

Q9NZW4
SSDSSNSSDSSDSSD

DSPP

746

Q9NZW4
NSSDSSDSSDSSNSS

DSPP

751

Q9NZW4
SDSSDSSNSSDSSDS

DSPP

756

Q9NZW4
SSNSSDSSDSSDSSD

DSPP

761

Q9NZW4
DSSDSSDSSDSSDSS

DSPP

766

Q9NZW4
SDSSDSSDSSNSSDS

DSPP

771

Q9NZW4
SSDSSNSSDSNDSSN

DSPP

776

Q9NZW4
NSSDSNDSSNSSDSS

DSPP

781

Q9NZW4
NDSSNSSDSSDSSNS

DSPP

786

Q9NZW4
SSDSSDSSNSSDSSN

DSPP

791

Q9NZW4
DSSNSSDSSNSSDSS

DSPP

796

Q9NZW4
SDSSNSSDSSDSSDS

DSPP

801

Q9NZW4
SSDSSDSSDSSDSDS

DSPP

806

Q9NZW4
DSSDSSDSDSSNSSD

DSPP

811

Q9NZW4
SDSDSSNSSDSSNSS

DSPP

816

Q9NZW4
SNSSDSSNSSDSSDS

DSPP

821

Q9NZW4
SSNSSDSSDSSNSSD

DSPP

826

Q9NZW4
DSSDSSNSSDSSDSS

DSPP

831

Q9NZW4
SNSSDSSDSSDSSDG

DSPP

836

Q9NZW4
SSDSSDSSDGSDSDS

DSPP

841

Q9NZW4
SDSDSSNRSDSSNSS

DSPP

851

Q9NZW4
SNRSDSSNSSDSSDS

DSPP

856

Q9NZW4
SSNSSDSSDSSDSSN

DSPP

861

Q9NZW4
DSSDSSDSSNSSDSS

DSPP

866

Q9NZW4
SDSSNSSDSSDSSDS

DSPP

871

Q9NZW4
SSDSSDSSDSNESSN

DSPP

876

Q9NZW4
DSSDSNESSNSSDSS

DSPP

881

Q9NZW4
NESSNSSDSSDSSNS

DSPP

886

Q9NZW4
SSDSSDSSNSSDSDS

DSPP

891

Q9NZW4
DSSNSSDSDSSDSSN

DSPP

896

Q9NZW4
SDSDSSDSSNSSDSS

DSPP

901

Q9NZW4
SDSSNSSDSSDSSNS

DSPP

906

Q9NZW4
SSDSSDSSNSSDSSE

DSPP

911

Q9NZW4
DSSNSSDSSESSNSS

DSPP

916

Q9NZW4
SDSSESSNSSDNSNS

DSPP

921

Q9NZW4
DNSNSSDSSNSSDSS

DSPP

931

Q9NZW4
SDSSNSSDSSDSSDS

DSPP

936

Q9NZW4
SSDSSDSSDSSNSSD

DSPP

941

Q9NZW4
DSSDSSNSSDSSNSS

DSPP

946

Q9NZW4
SSNSSDSSNSSDSSD

DSPP

956

Q9NZW4
DSSNSSDSSDSNSSD

DSPP

961

Q9NZW4
SDSSDSNSSDSSDSS

DSPP

966

Q9NZW4
SNSSDSSDSSNSSDS

DSPP

971

Q9NZW4
SSDSSNSSDSSDSSD

DSPP

976

Q9NZW4
NSSDSSDSSDSSDSS

DSPP

981

Q9NZW4
SDSSDSSDSSDSSDS

DSPP

986

Q9NZW4
SSDSSDSSDSSNSSD

DSPP

991

Q9NZW4
DSSDSSNSSDSSDSS

DSPP

996

Q9NZW4
SNSSDSSDSSDSSDS

DSPP

1001

Q9NZW4
SSDSSDSSDSSNSSD

DSPP

1006

Q9NZW4
DSSDSSNSSDSSNSS

DSPP

1011

Q9NZW4
SSNSSDSSNSSDSSD

DSPP

1021

Q9NZW4
DSSNSSDSSDSSDSS

DSPP

1026

Q9NZW4
SDSSDSSDSSDSSDS

DSPP

1031

Q9NZW4
SSDSSDSSDSSDSSD

DSPP

1036

Q9NZW4
DSSDSSDSSDSSDSS

DSPP

1041

Q9NZW4
SDSSDSSDSSNSSDS

DSPP

1046

Q9NZW4
SSDSSNSSDSSDSSD

DSPP

1051

Q9NZW4
NSSDSSDSSDSSDSS

DSPP

1056

Q9NZW4
SDSSDSSDSSDSSDS

DSPP

1061

Q9NZW4
SSDSSDSSDSSDSSD

DSPP

1066

Q9NZW4
DSSDSSDSSDSSESS

DSPP

1071

Q9NZW4
SDSSDSSESSDSSDS

DSPP

1076

Q9NZW4
SSESSDSSDSSNSSD

DSPP

1081

Q9NZW4
DSSDSSNSSDSSDSS

DSPP

1086

Q9NZW4
SNSSDSSDSSDSSDS

DSPP

1091

Q9NZW4
SSDSSDSSDSSDSSD

DSPP

1096

Q9NZW4
DSSDSSDSSDSSDSS

DSPP

1101

Q9NZW4
SDSSDSSDSSDSSDS

DSPP

1106

Q9NZW4
SSDSSDSSDSSNSSD

DSPP

1111

Q9NZW4
DSSDSSNSSDSSDSS

DSPP

1116

Q9NZW4
SNSSDSSDSSDSSDS

DSPP

1121

Q9NZW4
SSDSSDSSDSSDSSN

DSPP

1126

Q9NZW4
DSSDSSDSSNSSDSS

DSPP

1131

Q9NZW4
SDSSNSSDSSDSSES

DSPP

1136

Q9NZW4
SSDSSDSSESSDSSD

DSPP

1141

Q9NZW4
DSSESSDSSDSSDSS

DSPP

1146

Q9NZW4
SDSSDSSDSSDSSDS

DSPP

1151

Q9NZW4
SSDSSDSSDSSDSSD

DSPP

1156

Q9NZW4
DSSDSSDSSDSSDSS

DSPP

1161

Q9NZW4
SDSSDSSDSSDSSNS

DSPP

1166

Q9NZW4
SSDSSDSSNSSDSSD

DSPP

1171

Q9NZW4
DSSNSSDSSDSSDSS

DSPP

1176

Q9NZW4
SDSSDSSDSSDSSDS

DSPP

1181

Q9NZW4
SSDSSDSSDSSDSSD

DSPP

1186

Q9NZW4
DSSDSSDSSDSSDSS

DSPP

1191

Q9NZW4
SDSSDSSDSSDSSDS

DSPP

1196

Q9NZW4
SSDSSDSSDSSDSSD

DSPP

1201

Q9NZW4
DSSDSSDSSDSSDSS

DSPP

1206

Q9NZW4
SDSSDSSDSSDSSDS

DSPP

1211

Q9NZW4
SSDSSDSSDSSDSSD

DSPP

1216

Q9NZW4
DSSDSSDSSDSNESS

DSPP

1221

Q9NZW4
SDSSDSNESSDSSDS

DSPP

1226

Q9NZW4
SNESSDSSDSSDSSD

DSPP

1231

Q9NZW4
DSSDSSDSSDSSNSS

DSPP

1236

Q9NZW4
SDSSDSSNSSDSSDS

DSPP

1241

Q9NZW4
SSNSSDSSDSSDSSD

DSPP

1246

Q9NZW4
DSSDSSDSSDSTSDS

DSPP

1251

Q9NZW4
SSSGSDSESESSSSD

AFF4

436

Q9UHB7
SSSDSDSDSDSSGTS

FBXL19

326

Q6PCT2
SSSSSSSSSSDSDSE

JMJD6

346

Q6NYC1
SSSDSSSSSSDSDTD

IMUP

51

Q9GZP8
SSSASSSSESDSSDS

CWC22

671

Q9HCG8
SSSESDSSDSDSDSS

CWC22

676

Q9HCG8
DSSSESSSEESDSSS

CWC22

691

Q9HCG8
EDESSSSSSSSSSED

DCAF5

556

Q96JK2
TSSDDSSSDESSSSE

KANK1

1006

Q14678
SSSSSSSSSSEDSDS

MEIOSIN

456

C9JSJ3
SSSSSSSDSDSSSDS

PPIG

196

Q13427
SSDSDSSSDSQSSSD

PPIG

201

Q13427
SSSDSQSSSDSSDSE

PPIG

206

Q13427
SSSPSSSSSESSEDD

PRICKLE3

546

O43900
SSSSSSSSEESDSDE

CHD9

2186

Q3L8U1
SDSTSSSSEDSDSSN

CHD9

2881

Q3L8U1
SSSTSSSSSSDEEDD

CBX2

111

Q14781
SSSSDSSDSDEDSSS

GPALPP1

41

Q8IXQ4
PSNSSSSSDSSSDSD

MLLT1

376

Q03111
VSSDSDSDSDLSSSS

RPH3AL

206

Q9UNE2
SDSDSNSSSSSSDSD

RTF1

156

Q92541
NSSSSSSDSDSSSED

RTF1

161

Q92541
SSSSSSSGSSSSDDE

SOX4

386

Q06945
EGSDSSSNSSSSSES

NKTR

196

P30414
SSNSSSSSESSSESE

NKTR

201

P30414
EESDSSSSSSSTSDS

NAP1L3

31

Q99457
ENDSTSDSESSSSSS

SETD1A

1026

O15047
SSSSSSSSESSSEDE

SETD1A

1051

O15047
SSSSSSSSDTSDSDS

BRD2

786

P25440
SSSAESESTSDSDSS

AFF1

466

P51825
SESTSDSDSSSDSES

AFF1

471

P51825
DSDSSSDSESESSSS

AFF1

476

P51825
SSDSSDSSSSSSDDS

SPEN

291

Q96T58
SSENDLSSESSSSSS

RNF111

256

Q6ZNA4
SSSSSTHSDSSSDNE

RPAP2

206

Q8IXW5
SSSSSSSSSSESNDE

TMEM40

61

Q8WWA1
SEDSDTDESSSSSSS

ZCCHC10

136

Q8TBK6
TSSSSSDSDSDSSSS

ZCCHC10

156

Q8TBK6
SDSDSDSSSSSSSST

ZCCHC10

161

Q8TBK6
DSETDSDSSSSSSSS

NAF1

121

Q96HR8