Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontRNA (cytidine) methyltransferase activity

NSUN4 METTL2A METTL2B

4.07e-0610663GO:0016427
GeneOntologyMolecularFunctionephrin receptor activity

EPHA2 EPHA7 EPHB1

3.22e-0519663GO:0005003
GeneOntologyMolecularFunctiontRNA (cytidine-3-)-methyltransferase activity

METTL2A METTL2B

6.43e-054662GO:0052735
GeneOntologyMolecularFunctionrRNA (cytosine-C5-)-methyltransferase activity

NSUN4 NOP2

6.43e-054662GO:0009383
GeneOntologyMolecularFunctionRNA methyltransferase activity

NSUN4 METTL2A NOP2 METTL2B

7.13e-0567664GO:0008173
GeneOntologyMolecularFunctionrRNA (cytosine) methyltransferase activity

NSUN4 NOP2

1.60e-046662GO:0016434
GeneOntologyMolecularFunctiontRNA methyltransferase activity

NSUN4 METTL2A METTL2B

1.92e-0434663GO:0008175
GeneOntologyMolecularFunctionC-methyltransferase activity

NSUN4 NOP2

2.97e-048662GO:0008169
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC52A1 SLCO2A1 SLC39A6 GRIK5 GRIN1 SLC1A6

4.12e-04293666GO:0008514
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

ROCK2 CSNK1G2 EPHA2 BTK DGKI PRKDC LRRK1 EPHA7 EPHB1

5.16e-04709669GO:0016773
GeneOntologyMolecularFunctiondipeptidyl-peptidase activity

DPP7 DPP8

6.95e-0412662GO:0008239
GeneOntologyMolecularFunctionprotein kinase activity

ROCK2 CSNK1G2 EPHA2 BTK PRKDC LRRK1 EPHA7 EPHB1

7.86e-04600668GO:0004672
GeneOntologyMolecularFunctionaxon guidance receptor activity

EPHA7 EPHB1

8.20e-0413662GO:0008046
GeneOntologyMolecularFunctionkinase activity

ROCK2 CSNK1G2 EPHA2 BTK DGKI PRKDC LRRK1 EPHA7 EPHB1

8.80e-04764669GO:0016301
GeneOntologyMolecularFunctionglutamate binding

GAD1 GRIN1

9.54e-0414662GO:0016595
GeneOntologyMolecularFunctiontransmembrane-ephrin receptor activity

EPHA7 EPHB1

1.10e-0315662GO:0005005
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

EPHA2 EPHA7 EPHB1

1.30e-0365663GO:0004714
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

EPHA2 BTK EPHA7 EPHB1

1.36e-03145664GO:0004713
GeneOntologyMolecularFunctionglutamate-gated receptor activity

GRIK5 GRIN1

1.42e-0317662GO:0004970
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

NRXN3 OR9A4 OR1B1 OR51I1 EPHA2 GRIK5 GRIN1 OR51G1 OR52N1 IL6ST EPHA7 EPHB1

1.44e-0313536612GO:0004888
GeneOntologyMolecularFunctionmolecular function activator activity

ROCK2 RGPD8 EPHA2 BTK PLCB1 FGF11 C5 DNAJC7 IL6ST EPHA7 RGPD5

2.22e-0312336611GO:0140677
GeneOntologyMolecularFunctionS-adenosylmethionine-dependent methyltransferase activity

NSUN4 METTL2A NOP2 METTL2B

2.53e-03172664GO:0008757
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

EPHA2 EPHA7 EPHB1

2.81e-0385663GO:0019199
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

GRIK5 GRIN1

2.83e-0324662GO:0099507
GeneOntologyMolecularFunctionrRNA methyltransferase activity

NSUN4 NOP2

2.83e-0324662GO:0008649
GeneOntologyMolecularFunctioncatalytic activity, acting on a rRNA

NSUN4 NOP2

3.07e-0325662GO:0140102
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

ROCK2 CSNK1G2 EPHA2 BTK DGKI PRKDC LRRK1 EPHA7 EPHB1

3.58e-03938669GO:0016772
GeneOntologyMolecularFunctionglutamate receptor activity

GRIK5 GRIN1

3.58e-0327662GO:0008066
GeneOntologyCellularComponentpresynaptic active zone

ROCK2 GAD1 NRXN3 DGKI GRIN1 CTNND1

6.02e-06141676GO:0048786
GeneOntologyCellularComponentpresynapse

ROCK2 RAB10 GAD1 ATP6V0A1 NRXN3 MTMR2 EXOC3 DGKI GRIK5 GRIN1 CTNND1 SLC1A6

2.18e-058866712GO:0098793
GeneOntologyCellularComponenthippocampal mossy fiber to CA3 synapse

GRIK5 GRIN1 CTNND1 EPHA7

6.35e-0567674GO:0098686
GeneOntologyCellularComponentglutamatergic synapse

ROCK2 NRXN3 PLCB1 DGKI GRIK5 GRIN1 CTNND1 SLC1A6 EPHA7 EPHB1

2.59e-048176710GO:0098978
GeneOntologyCellularComponentpresynaptic membrane

NRXN3 EXOC3 DGKI GRIK5 GRIN1 SLC1A6

2.60e-04277676GO:0042734
GeneOntologyCellularComponentsynaptic membrane

NRXN3 MTMR2 EXOC3 DGKI GRIK5 GRIN1 SLC1A6 EPHA7

5.35e-04583678GO:0097060
GeneOntologyCellularComponentpostsynaptic density

ROCK2 MTMR2 DGKI GRIK5 GRIN1 CTNND1 EPHA7

5.92e-04451677GO:0014069
GeneOntologyCellularComponentasymmetric synapse

ROCK2 MTMR2 DGKI GRIK5 GRIN1 CTNND1 EPHA7

8.23e-04477677GO:0032279
GeneOntologyCellularComponentpostsynaptic specialization

ROCK2 MTMR2 DGKI GRIK5 GRIN1 CTNND1 EPHA7

1.12e-03503677GO:0099572
GeneOntologyCellularComponentneuron to neuron synapse

ROCK2 MTMR2 DGKI GRIK5 GRIN1 CTNND1 EPHA7

1.40e-03523677GO:0098984
GeneOntologyCellularComponentSchaffer collateral - CA1 synapse

ROCK2 DGKI CTNND1 EPHA7

1.55e-03155674GO:0098685
GeneOntologyCellularComponentpostsynaptic density membrane

DGKI GRIK5 GRIN1 EPHA7

1.63e-03157674GO:0098839
GeneOntologyCellularComponentpresynaptic active zone membrane

NRXN3 DGKI GRIN1

2.02e-0378673GO:0048787
GeneOntologyCellularComponentexocyst

RAB10 EXOC3

2.04e-0321672GO:0000145
GeneOntologyCellularComponentlamellipodium membrane

EPHA2 SLC39A6

2.24e-0322672GO:0031258
GeneOntologyCellularComponentexocytic vesicle membrane

RAB10 ATP6V0A1 DGKI GRIN1

2.62e-03179674GO:0099501
GeneOntologyCellularComponentsynaptic vesicle membrane

RAB10 ATP6V0A1 DGKI GRIN1

2.62e-03179674GO:0030672
GeneOntologyCellularComponentdistal axon

GAD1 EXOC3 DGKI GRIK5 GRIN1 CTNND1

2.68e-03435676GO:0150034
GeneOntologyCellularComponentsynaptic vesicle

RAB10 ATP6V0A1 MTMR2 DGKI GRIN1

2.75e-03300675GO:0008021
GeneOntologyCellularComponentperinuclear region of cytoplasm

RAB10 GAD1 ATP6V0A1 RGPD8 UBR5 BTK MTMR2 EXOC3 DGKI

2.85e-03934679GO:0048471
GeneOntologyCellularComponentaxonemal dynein complex

DNAI1 DNAH2

2.89e-0325672GO:0005858
GeneOntologyCellularComponentexocytic vesicle

RAB10 ATP6V0A1 MTMR2 DGKI GRIN1

3.62e-03320675GO:0070382
GeneOntologyCellularComponentpostsynaptic specialization membrane

DGKI GRIK5 GRIN1 EPHA7

3.96e-03201674GO:0099634
DomainRECEPTOR_TYR_KIN_V_2

EPHA2 EPHA7 EPHB1

1.42e-0514653PS00791
DomainRECEPTOR_TYR_KIN_V_1

EPHA2 EPHA7 EPHB1

1.42e-0514653PS00790
DomainEph_TM

EPHA2 EPHA7 EPHB1

1.42e-0514653IPR027936
DomainTyr_kinase_rcpt_V_CS

EPHA2 EPHA7 EPHB1

1.42e-0514653IPR001426
DomainEPH_lbd

EPHA2 EPHA7 EPHB1

1.42e-0514653SM00615
DomainEphrin_lbd

EPHA2 EPHA7 EPHB1

1.42e-0514653PF01404
DomainEphA2_TM

EPHA2 EPHA7 EPHB1

1.42e-0514653PF14575
DomainTyr_kinase_ephrin_rcpt

EPHA2 EPHA7 EPHB1

1.42e-0514653IPR016257
DomainEphrin_rcpt_lig-bd_dom

EPHA2 EPHA7 EPHB1

1.42e-0514653IPR001090
DomainEPH_LBD

EPHA2 EPHA7 EPHB1

1.42e-0514653PS51550
DomainTPR_REGION

RGPD8 DNAH2 TMTC2 PRKDC DNAJC7 RGPD5

2.33e-05165656PS50293
DomainTPR

RGPD8 DNAH2 TMTC2 PRKDC DNAJC7 RGPD5

2.33e-05165656PS50005
DomainMeTrfase

METTL2A METTL2B

7.12e-054652IPR026113
DomainEphrin_rec_like

EPHA2 EPHA7 EPHB1

8.76e-0525653SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

EPHA2 EPHA7 EPHB1

8.76e-0525653IPR011641
DomainTPR-like_helical_dom

RGPD8 TMTC2 SEL1L2 PRKDC DNAJC7 RGPD5

1.58e-04233656IPR011990
DomainTPR-contain_dom

RGPD8 TMTC2 PRKDC DNAJC7 RGPD5

1.75e-04150655IPR013026
DomainMethyltransf_12

METTL2A METTL2B

1.77e-046652PF08242
DomainNOL1_NOP2_SUN

NSUN4 NOP2

1.77e-046652PS01153
DomainRCMT

NSUN4 NOP2

1.77e-046652IPR023267
DomainMethyltransf_12

METTL2A METTL2B

1.77e-046652IPR013217
DomainSAM_MT_RSMB_NOP

NSUN4 NOP2

2.48e-047652PS51686
DomainTyrKc

EPHA2 BTK EPHA7 EPHB1

2.50e-0488654SM00219
DomainTyr_kinase_cat_dom

EPHA2 BTK EPHA7 EPHB1

2.50e-0488654IPR020635
DomainTPR_1

RGPD8 TMTC2 DNAJC7 RGPD5

2.73e-0490654PF00515
DomainTPR_1

RGPD8 TMTC2 DNAJC7 RGPD5

2.73e-0490654IPR001440
DomainMeTrfase_RsmB/NOP2

NSUN4 NOP2

3.29e-048652IPR001678
DomainMethyltr_RsmB-F

NSUN4 NOP2

3.29e-048652PF01189
DomainPROTEIN_KINASE_TYR

EPHA2 BTK EPHA7 EPHB1

3.63e-0497654PS00109
DomainTyr_kinase_AS

EPHA2 BTK EPHA7 EPHB1

3.63e-0497654IPR008266
DomainFN3

KIAA0319 EPHA2 IL6ST EPHA7 EPHB1

4.61e-04185655SM00060
DomainKinase-like_dom

ROCK2 CSNK1G2 EPHA2 BTK PRKDC LRRK1 EPHA7 EPHB1

5.63e-04542658IPR011009
DomainGrip

RGPD8 RGPD5

6.43e-0411652SM00755
DomainGRIP

RGPD8 RGPD5

6.43e-0411652PF01465
DomainRan_BP1

RGPD8 RGPD5

7.70e-0412652PF00638
DomainGRIP_dom

RGPD8 RGPD5

7.70e-0412652IPR000237
DomainGRIP

RGPD8 RGPD5

7.70e-0412652PS50913
DomainRANBD1

RGPD8 RGPD5

7.70e-0412652PS50196
Domain-

C5 RABGGTB

7.70e-04126521.50.10.20
DomainFN3_dom

KIAA0319 EPHA2 IL6ST EPHA7 EPHB1

8.01e-04209655IPR003961
Domain-

NSUN4 METTL2A NOP2 METTL2B

8.11e-041206543.40.50.150
DomainSAM-dependent_MTases

NSUN4 METTL2A NOP2 METTL2B

8.63e-04122654IPR029063
DomainRanBD

RGPD8 RGPD5

9.08e-0413652SM00160
DomainRan_bind_dom

RGPD8 RGPD5

9.08e-0413652IPR000156
DomainPROTEIN_KINASE_ATP

ROCK2 CSNK1G2 EPHA2 BTK LRRK1 EPHA7 EPHB1

1.05e-03459657PS00107
DomainPkinase_Tyr

EPHA2 BTK EPHA7 EPHB1

1.06e-03129654PF07714
DomainSer-Thr/Tyr_kinase_cat_dom

EPHA2 BTK EPHA7 EPHB1

1.36e-03138654IPR001245
DomainProt_kinase_dom

ROCK2 CSNK1G2 EPHA2 BTK LRRK1 EPHA7 EPHB1

1.52e-03489657IPR000719
DomainPROTEIN_KINASE_DOM

ROCK2 CSNK1G2 EPHA2 BTK LRRK1 EPHA7 EPHB1

1.59e-03493657PS50011
DomainSAM_1

EPHA2 EPHA7 EPHB1

1.72e-0368653PF00536
DomainIontro_rcpt

GRIK5 GRIN1

1.76e-0318652IPR001320
DomainLig_chan-Glu_bd

GRIK5 GRIN1

1.76e-0318652PF10613
DomainIono_rcpt_met

GRIK5 GRIN1

1.76e-0318652IPR001508
DomainGlu/Gly-bd

GRIK5 GRIN1

1.76e-0318652IPR019594
DomainLig_chan-Glu_bd

GRIK5 GRIN1

1.76e-0318652SM00918
DomainLig_chan

GRIK5 GRIN1

1.76e-0318652PF00060
DomainPBPe

GRIK5 GRIN1

1.76e-0318652SM00079
DomainTerpenoid_cyclase/PrenylTrfase

C5 RABGGTB

1.76e-0318652IPR008930
DomainHEAT_REPEAT

CAND1 HEATR6 PRKDC

1.86e-0370653PS50077
DomainProtein_kinase_ATP_BS

ROCK2 CSNK1G2 EPHA2 BTK EPHA7 EPHB1

2.02e-03379656IPR017441
Domain-

EPHA2 EPHA7 EPHB1

2.10e-03736532.60.120.260
Domainfn3

EPHA2 IL6ST EPHA7 EPHB1

2.45e-03162654PF00041
DomainSAM

EPHA2 EPHA7 EPHB1

3.58e-0388653SM00454
DomainPH_dom-like

ROCK2 RGPD8 BTK MTMR2 PLCB1 RGPD5

3.61e-03426656IPR011993
DomainGalactose-bd-like

EPHA2 EPHA7 EPHB1

4.30e-0394653IPR008979
DomainSAM_DOMAIN

EPHA2 EPHA7 EPHB1

4.43e-0395653PS50105
DomainSAM

EPHA2 EPHA7 EPHB1

4.70e-0397653IPR001660
DomainFN3

EPHA2 IL6ST EPHA7 EPHB1

5.10e-03199654PS50853
Domain-

RGPD8 TMTC2 SEL1L2 DNAJC7

5.86e-032076541.25.40.10
Domain-

EPHA2 EPHA7 EPHB1

6.01e-031066531.10.150.50
PathwayREACTOME_EPH_EPHRIN_SIGNALING

ROCK2 EPHA2 GRIN1 EPHA7 EPHB1

4.31e-0665535MM14911
PathwayREACTOME_EPH_EPHRIN_SIGNALING

ROCK2 EPHA2 GRIN1 EPHA7 EPHB1

2.38e-0592535M27201
PathwayREACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE

ROCK2 EPHA2 EPHA7

1.71e-0429533M27309
PathwayWP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING

PLCB1 GRIK5 GRIN1 SLC1A6 IL6ST

1.76e-04140535M42572
PathwayREACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS

EPHA2 EPHA7 EPHB1

2.77e-0434533MM15025
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

ROCK2 RAB10 CAND1 UBR5 PLCB1 GRIK5 GRIN1 CTNND1

2.97e-0825167827507650
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

KIAA0319 ROCK2 RAB10 CAND1 RGPD8 UBR5 LSG1 PLCB1 DGKI GRIK5 GRIN1 CTNND1 NOP2

3.30e-08963671328671696
Pubmed

Degenerate PCR-based cloning method for Eph receptors and analysis of their expression in the developing murine central nervous system and vasculature.

EPHA2 EPHA7 EPHB1

5.69e-07967311403717
Pubmed

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.

ROCK2 CAND1 CSNK1G2 EPHA2 PLCB1 SLC39A6 CTNND1 IL6ST

6.61e-0737767838117590
Pubmed

Ephrin/ephrin receptor expression during early stages of mouse inner ear development.

EPHA2 EPHA7 EPHB1

1.48e-061267321465626
Pubmed

Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue.

EPHA2 EPHA7 EPHB1

2.45e-061467326941654
Pubmed

A protein interaction landscape of breast cancer.

CAND1 HEATR6 UBR5 LSG1 SMARCB1 TMTC2 CTNND1 DNAJC7 NOP2

3.50e-0663467934591612
Pubmed

Divergent iron regulatory states contribute to heterogeneity in breast cancer aggressiveness.

PRKDC C5

3.66e-06267239262774
Pubmed

Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization.

BTK PRKDC

3.66e-06267215385481
Pubmed

Caffeine Supplementation and FOXM1 Inhibition Enhance the Antitumor Effect of Statins in Neuroblastoma.

PRKDC C5

3.66e-06267237057874
Pubmed

Descending Command Neurons in the Brainstem that Halt Locomotion.

GAD1 VSX2

3.66e-06267226590422
Pubmed

Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy against Highly Resistant BCR-ABL1 Mutants.

PRKDC C5

3.66e-06267231543464
Pubmed

Incompatibility in cell adhesion constitutes a barrier to interspecies chimerism.

PRKDC C5

3.66e-06267239181131
Pubmed

Isolation of slow-cycling cancer cells from lung patient-derived xenograft using carboxyfluorescein-succinimidyl ester retention-mediated cell sorting.

PRKDC C5

3.66e-06267236924504
Pubmed

Expression of Mls determinants in mice exhibiting the severe combined immunodeficiency (scid) mutation or X-linked immunodeficiency (xid) defect.

BTK PRKDC

3.66e-0626721506683
Pubmed

Targeting ferritinophagy impairs quiescent cancer stem cells in acute myeloid leukemia in vitro and in vivo models.

PRKDC C5

3.66e-06267239047119
Pubmed

NMDA Receptor Activation Underlies the Loss of Spinal Dorsal Horn Neurons and the Transition to Persistent Pain after Peripheral Nerve Injury.

GAD1 GRIN1

3.66e-06267229847798
Pubmed

Ability of spleen, peritoneal cavity, and lymph node B cells to reconstitute serum immunoglobulin in SCID mice.

BTK PRKDC

3.66e-0626728707345
Pubmed

Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency.

PRKDC C5

3.66e-06267234702956
Pubmed

An in vivo neuroimmune organoid model to study human microglia phenotypes.

PRKDC C5

3.66e-06267237172564
Pubmed

Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.

EPHA2 EPHA7 EPHB1

3.76e-06166738755474
Pubmed

Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice.

EPHA2 EPHA7 EPHB1

4.56e-061767312217323
Pubmed

Expression of Ephs and ephrins in developing mouse inner ear.

EPHA2 EPHA7 EPHB1

6.48e-061967312684176
Pubmed

Multiple roles of EPH receptors and ephrins in neural development.

EPHA2 EPHA7 EPHB1

7.61e-062067311256076
Pubmed

The ephrins and Eph receptors in neural development.

EPHA2 EPHA7 EPHB1

7.61e-06206739530499
Pubmed

Eph receptors and ephrins: effectors of morphogenesis.

EPHA2 EPHA7 EPHB1

7.61e-062067310207129
Pubmed

The Eph family receptors and ligands.

EPHA2 EPHA7 EPHB1

7.61e-06206739576626
Pubmed

Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.

EPHA2 EPHA7 EPHB1

8.87e-06216739267020
Pubmed

Eph receptors and ephrins demarcate cerebellar lobules before and during their formation.

EPHA2 EPHA7 EPHB1

8.87e-062167310495276
Pubmed

Developmental expression of Eph and ephrin family genes in mammalian small intestine.

EPHA2 EPHA7 EPHB1

8.87e-062167320112066
Pubmed

Roles of Eph receptors and ephrins in segmental patterning.

EPHA2 EPHA7 EPHB1

8.87e-062167311128993
Pubmed

Eph receptors and ephrins: regulators of guidance and assembly.

EPHA2 EPHA7 EPHB1

8.87e-062167310730216
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

BNC2 CSNK1G2 CTNND1 ELOVL6 METTL2A DNAJC7 RABGGTB METTL2B

8.87e-0653667815840001
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

BNC2 CSNK1G2 CTNND1 ELOVL6 METTL2A DNAJC7 RABGGTB METTL2B

9.12e-0653867810512203
Pubmed

Exploring the link between germline and somatic genetic alterations in breast carcinogenesis.

EPHA7 EPHB1

1.10e-05367221124932
Pubmed

Use of a genetically engineered strain to evaluate the pathogenic potential of yeast cell and filamentous forms during Candida albicans systemic infection in immunodeficient mice.

PRKDC C5

1.10e-05367217967861
Pubmed

FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth.

FKBP10 PRKDC

1.10e-05367232187554
Pubmed

Mechanosensing through YAP controls T cell activation and metabolism.

PRKDC C5

1.10e-05367232484502
Pubmed

Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system of the mouse.

EPHA2 EPHB1

1.10e-0536727609620
Pubmed

Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancer.

EPHA2 EPHA7

1.10e-05367216862074
Pubmed

Origin, prospective identification, and function of circulating endothelial colony-forming cells in mice and humans.

PRKDC C5

1.10e-05367236692963
Pubmed

Bruton's tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis.

BTK PRKDC

1.10e-05367232484802
Pubmed

Uncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis.

PRKDC C5

1.10e-05367237084714
Pubmed

HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties.

PRKDC C5

1.10e-05367230074477
Pubmed

G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment.

PRKDC C5

1.10e-05367235767962
Pubmed

Thyroid hormone suppresses medulloblastoma progression through promoting terminal differentiation of tumor cells.

PRKDC C5

1.10e-05367239137728
Pubmed

DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification.

METTL2A METTL2B

1.10e-05367232427860
Pubmed

Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling.

EPHA2 EPHA7 EPHB1

1.18e-052367319542359
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

FKBP10 RAB10 ATP6V0A1 CAND1 UBR5 EPHA2 DNAH2 PRKDC DNAJC7 RABGGTB

1.24e-05942671031073040
Pubmed

Eph receptors and their ephrin ligands are expressed in developing mouse pancreas.

EPHA2 EPHA7 EPHB1

1.34e-052467316446123
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

ROCK2 CSNK1G2 EPHA2 PLCB1 EXOC3 CTNND1 IL6ST EPHA7

1.37e-0556967830639242
Pubmed

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.

CAND1 CSNK1G2 EPHA2 GRIK5 PRKDC B4GALT3

1.57e-0527667628319085
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

ROCK2 EPHA2 MTMR2 PLCB1 SLC39A6 EXOC3 CTNND1

1.69e-0542167736976175
Pubmed

The protein tyrosine kinase family of the human genome.

EPHA2 BTK EPHA7 EPHB1

2.06e-058367411114734
Pubmed

Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity.

BTK PRKDC

2.19e-05467221030983
Pubmed

Eph/ephrin signalling serves a bidirectional role in lipopolysaccharide‑induced intestinal injury.

EPHA2 EPHB1

2.19e-05467229901151
Pubmed

B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites.

BTK PRKDC

2.19e-05467210684864
Pubmed

Strain-dependent leakiness of mice with severe combined immune deficiency.

BTK PRKDC

2.19e-0546728473734
Pubmed

The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma.

PRKDC C5

2.19e-05467231484063
Pubmed

Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma.

BTK C5

2.19e-05467215379984
Pubmed

LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain.

EPHA2 EPHB1

2.19e-0546729245480
Pubmed

Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6.

METTL2A METTL2B

2.19e-05467234268557
Pubmed

Cross-Reactive Antigen Expressed by B6 Splenocytes Drives Receptor Editing and Marginal Zone Differentiation of IgG2a-Reactive AM14 Vκ8 B Cells.

BTK UNC93B1

2.19e-05467231534009
Pubmed

Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice.

BTK PRKDC

2.19e-0546723553324
Pubmed

Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.

RGPD8 RGPD5

2.19e-0546729480752
Pubmed

Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes.

PRKDC C5

2.19e-05467220033053
Pubmed

Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins.

METTL2A METTL2B

2.19e-05467211738826
Pubmed

Role of the NR2A/2B subunits of the N-methyl-D-aspartate receptor in glutamate-induced glutamic acid decarboxylase alteration in cortical GABAergic neurons in vitro.

GAD1 GRIN1

3.64e-05567220923697
Pubmed

The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes.

BTK PRKDC

3.64e-05567212646649
Pubmed

Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.

EPHA2 EPHA7

3.64e-05567221935409
Pubmed

Bruton's tyrosine kinase (Btk) enhances transcriptional co-activation activity of BAM11, a Btk-associated molecule of a subunit of SWI/SNF complexes.

BTK SMARCB1

3.64e-05567215096481
Pubmed

Expression and prognostic assessment of dipeptidyl peptidase IV and related enzymes in B-cell chronic lymphocytic leukemia.

DPP7 DPP8

3.64e-05567220534982
Pubmed

Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans.

METTL2A METTL2B

3.64e-05567228655767
Pubmed

The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma.

EPHA2 EPHA7

3.64e-05567222036564
Pubmed

Clinical significance of ephrin (eph)-A1, -A2, -a4, -a5 and -a7 receptors in pancreatic ductal adenocarcinoma.

EPHA2 EPHA7

3.64e-05567219949912
Pubmed

Eph receptors are involved in the activity-dependent synaptic wiring in the mouse cerebellar cortex.

EPHA2 EPHB1

3.64e-05567221559471
Pubmed

PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer.

PRKDC C5

3.64e-05567238691454
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

ROCK2 RAB10 CAND1 SLC39A6 PRKDC CTNND1

3.73e-0532267626514267
Pubmed

Genetic regulation of glutamate receptor ion channels.

GRIK5 GRIN1

5.46e-05667210331083
Pubmed

Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis.

EPHA2 EPHB1

5.46e-05667219567782
Pubmed

Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis.

PRKDC C5

5.46e-05667237541213
Pubmed

Nasopharyngeal Exposure to Streptococcus pneumoniae Induces Extended Age-Dependent Protection against Pulmonary Infection Mediated by Antibodies and CD138+ Cells.

BTK PRKDC

5.46e-05667229661828
Pubmed

Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors.

BTK UNC93B1

5.46e-05667217658280
Pubmed

D-serine availability modulates prefrontal cortex inhibitory interneuron development and circuit maturation.

GAD1 GRIN1

5.46e-05667237311798
Pubmed

Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.

EPHA2 EPHB1

5.46e-0566727973638
Pubmed

Overstimulation of NMDA receptors impairs early brain development in vivo.

GAD1 GRIN1

5.46e-05667222606296
Pubmed

Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response.

PRKDC C5

5.46e-05667218378907
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

ROCK2 RAB10 LSG1 EPHA2 EXOC3 PRKDC CTNND1 DNAJC7

6.42e-0570867839231216
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD8 RGPD5

7.63e-05767215710750
Pubmed

NMDA Receptor in Vasopressin 1b Neurons Is Not Required for Short-Term Social Memory, Object Memory or Aggression.

GAD1 GRIN1

7.63e-05767231787886
Pubmed

Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility.

PRKDC C5

7.63e-05767234015257
Pubmed

Wt1 Positive dB4 Neurons in the Hindbrain Are Crucial for Respiration.

GAD1 VSX2

7.63e-05767233328840
Pubmed

The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn).

CTNND1 NOP2

7.63e-05767212370829
Pubmed

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.

PRKDC C5

1.02e-04867229681511
Pubmed

Twist1 Activation in Muscle Progenitor Cells Causes Muscle Loss Akin to Cancer Cachexia.

PRKDC C5

1.02e-04867229920276
Pubmed

Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton.

HOXC10 VSX2

1.02e-04867212869760
Pubmed

Clmp Regulates AMPA and Kainate Receptor Responses in the Neonatal Hippocampal CA3 and Kainate Seizure Susceptibility in Mice.

GAD1 GRIK5

1.02e-04867233408624
Pubmed

Genetically determined murine models of immunodeficiency.

BTK PRKDC

1.02e-0486723297105
Pubmed

Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2.

EPHA2 EPHB1

1.02e-04867214988728
Pubmed

Dual-mode operation of neuronal networks involved in left-right alternation.

GAD1 VSX2

1.02e-04867223812590
InteractionDNAJC5 interactions

FKBP10 ATP6V0A1 NRXN3 EPHA2 SLC39A6 EXOC3 CTNND1 DNAJC7 EPHA7

2.20e-06378629int:DNAJC5
InteractionRHOQ interactions

ROCK2 ADIPOR1 ATP6V0A1 EPHA2 SLC39A6 EXOC3 CTNND1 IL6ST EPHA7

7.84e-06442629int:RHOQ
InteractionNRAS interactions

ROCK2 CSNK1G2 EPHA2 BTK PLCB1 SLC39A6 EXOC3 CTNND1 IL6ST RABGGTB EPHA7

8.19e-066996211int:NRAS
InteractionHRAS interactions

ROCK2 RAB10 HEATR6 EPHA2 BTK PLCB1 SLC39A6 EXOC3 GRIN1 CTNND1 RABGGTB

1.15e-057256211int:HRAS
InteractionMCAM interactions

ROCK2 ATP6V0A1 CAND1 CSNK1G2 EPHA2 PLCB1 SLC39A6 CTNND1 IL6ST

1.24e-05468629int:MCAM
InteractionC11orf52 interactions

EPHA2 PLCB1 SLC39A6 EXOC3 LRRK1 CTNND1 EPHA7

4.63e-05311627int:C11orf52
InteractionPSKH2 interactions

UBR5 PRKDC DNAJC7 RABGGTB

5.38e-0567624int:PSKH2
InteractionEPHA2 interactions

ROCK2 ATP6V0A1 CSNK1G2 EPHA2 MTMR2 PLCB1 SLC39A6 EXOC3 CTNND1 EPHA7

6.30e-057196210int:EPHA2
InteractionLAMTOR1 interactions

ROCK2 RAB10 ATP6V0A1 CSNK1G2 EPHA2 SLC39A6 EXOC3 CTNND1 DNAJC7 EPHA7

6.52e-057226210int:LAMTOR1
InteractionPSEN1 interactions

ATP6V0A1 FBXL12 GRIN1 CTNND1 METTL2A DNAJC7

6.94e-05227626int:PSEN1
InteractionRHOC interactions

ROCK2 ADIPOR1 ATP6V0A1 LSG1 EPHA2 SLC39A6 CTNND1 IL6ST EPHA7

6.99e-05584629int:RHOC
InteractionRGPD2 interactions

RGPD8 EXOC3 RGPD5

7.69e-0527623int:RGPD2
InteractionMRAP2 interactions

ADIPOR1 CSNK1G2 EPHA2 EPHA7

9.29e-0577624int:MRAP2
InteractionTMEM216 interactions

ATP6V0A1 LSG1 EPHA2 SLC39A6 CTNND1 EPHA7

1.08e-04246626int:TMEM216
GeneFamilyFibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors

EPHA2 EPHA7 EPHB1

6.67e-06144931095
GeneFamilyCD molecules|DASH family

DPP7 DPP8

1.50e-0474921205
GeneFamilyNOP2/Sun RNA methyltransferase family

NSUN4 NOP2

1.50e-047492664
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD8 TMTC2 DNAJC7 RGPD5

2.64e-04115494769
GeneFamilyFibronectin type III domain containing

EPHA2 IL6ST EPHA7 EPHB1

9.18e-04160494555
GeneFamilyDyneins, axonemal

DNAI1 DNAH2

9.53e-0417492536
GeneFamilySterile alpha motif domain containing

EPHA2 EPHA7 EPHB1

1.75e-0388493760
GeneFamilyMethyltransferase like

METTL2A METTL2B

3.60e-0333492963
GeneFamilySolute carriers

SLC35G1 SLC52A1 SLCO2A1 SLC39A6 SLC1A6

4.20e-03395495752
GeneFamilyOlfactory receptors, family 51

OR51I1 OR51G1

6.33e-0344492164
CoexpressionWANG_LMO4_TARGETS_DN

NSUN4 HEATR6 UBR5 MTMR2 EXOC3 TMTC2 CTNND1 DNAJC7

3.43e-06361668M12674
CoexpressionGSE22432_MULTIPOTENT_PROGENITOR_VS_PDC_UP

RAB10 NSUN4 ADIPOR1 DNAH2 FBXL12 C5

1.14e-05200666M7820
ComputationalGenes in the cancer module 80.

EPHA2 EPHA7 EPHB1

1.88e-0432383MODULE_80
ComputationalGenes in the cancer module 51.

EPHA2 EPHA7 EPHB1

2.69e-0436383MODULE_51
DiseaseMetastatic melanoma

ROCK2 PRKDC EPHA7

1.66e-0454583C0278883
DiseaseDrug toxicity

EPHX2 SLCO2A1 EPHA7

6.13e-0484583C0013221
DiseaseAdverse reaction to drug

EPHX2 SLCO2A1 EPHA7

6.13e-0484583C0041755
Diseaseneuritic plaque measurement

NRXN3 PLCB1 GRIK5 SLC1A6 EPHB1

6.17e-04349585EFO_0006798
DiseaseAdenocarcinoma of large intestine

UBR5 PRKDC EPHA7

9.04e-0496583C1319315
Diseasemedial orbital frontal cortex volume measurement

NRXN3 EPHA7

1.11e-0325582EFO_0010315
DiseaseMyocardial Failure

ROCK2 EPHX2 ELOVL6

1.34e-03110583C1959583
DiseaseCongestive heart failure

ROCK2 EPHX2 ELOVL6

1.34e-03110583C0018802
DiseaseHeart failure

ROCK2 EPHX2 ELOVL6

1.34e-03110583C0018801
DiseaseLeft-Sided Heart Failure

ROCK2 EPHX2 ELOVL6

1.34e-03110583C0023212
DiseaseHeart Failure, Right-Sided

ROCK2 EPHX2 ELOVL6

1.34e-03110583C0235527
DiseaseHeart Decompensation

ROCK2 EPHX2 ELOVL6

1.34e-03110583C1961112
DiseaseSquamous cell carcinoma of lung

EPHA2 PRKDC

1.81e-0332582C0149782

Protein segments in the cluster

PeptideGeneStartEntry
AVMMYLSLGGFRSLS

B4GALT3

21

O60512
YMANGCLLNYLREMR

BTK

476

Q06187
LNGYGRGMAEDYMVL

BNC2

946

Q6ZN30
GMAISYMIYRLAQAE

C19orf18

116

Q8NEA5
GYGSYDFMKQSRGML

DNAI1

351

Q9UI46
TSYYRGAMGIMLVYD

RAB10

76

P61026
YMYAGSLLLKMGQHG

RGPD5

291

Q99666
YMYAGSLLLKMGQHG

RGPD8

291

O14715
RGIAAGMKYLAEMNY

EPHB1

726

P54762
MYYLLRGLSVIDMGL

OR1B1

61

Q8NGR6
MAVMYITGAGLYAAR

ADIPOR1

306

Q96A54
LQMGSLRAEDMAVYY

IGHV3-64

101

A0A075B6Q5
SEELLTAYGYMRGFM

LSG1

506

Q9H089
DMFSYGMVLYELLSG

LRRK1

1446

Q38SD2
EALGHMFMYFLRGSL

CSNK1G2

236

P78368
GTNNLGYMDLLRMLT

CAND1

766

Q86VP6
GGAISNMYSIMAARY

GAD1

251

Q99259
MYYFLGMLAVTDLGL

OR51G1

61

Q8NGK1
MYYFLSMLALNDLGV

OR51I1

61

Q9H343
GMVLLRDYGRYDMAQ

METTL2B

286

Q6P1Q9
DLYMAGLAQGMYSNL

NRXN3

991

Q9Y4C0
GYFSMTQAYLMELGE

HEATR6

701

Q6AI08
QLTSLAMLMLDGYYR

MTMR2

426

Q13614
AMLMLDGYYRTIRGF

MTMR2

431

Q13614
GIAAGMRYLADMGYV

EPHA7

741

Q15375
GMMLLRDYGRYDMAQ

METTL2A

286

Q96IZ6
RPGSLGVMEYYLMDA

NSUN4

146

Q96CB9
LGHYMAMNAEGLLYS

FGF11

121

Q92914
MSEYLRMSGIYWGLT

RABGGTB

41

P53611
YLYAITLLMLMGAAG

OTOP1

351

Q7RTM1
FGALRTGAYMVYILM

ELOVL6

76

Q9H5J4
GDFMRYHYNGSLMDG

FKBP10

286

Q96AY3
YRVLAMDMKGYGESS

EPHX2

286

P34913
TLYMVRMAAYTDEGG

IL6ST

586

P40189
RMLSDSGLGMIAPYY

DGKI

891

O75912
RGIAAGMKYLANMNY

EPHA2

721

P29317
EGMLSIMSYRNADYS

C5

1051

P01031
YGGYLSLMALMQRSD

DPP8

756

Q6V1X1
NKATGRMGMRAAVYY

SLC1A6

121

P48664
GGERYSRSAGMYMQS

HOXC10

21

Q9NYD6
NASYYGNRAATLMML

DNAJC7

61

Q99615
SRDGLMYEQYRMDSG

EXOC3

151

O60645
LMNYLRMVEYDGLTG

GRIK5

346

Q16478
EGLDYKSMGRMYSGL

DNAH2

1831

Q9P225
YGMMSDYGTARRTGT

CTNND1

296

O60716
GSYGGMLSAYLRMKY

DPP7

161

Q9UHL4
MYSIAITGNFGLMYL

OR52N1

36

Q8NH53
GGDFLRARMYSTALM

NXPE2

146

Q96DL1
MSQMILGYRYLSGIN

SEL1L2

216

Q5TEA6
YMASRLHSLRMGGYL

FBXL12

66

Q9NXK8
YMIGSEVGNYLRMFR

SMARCB1

26

Q12824
YLAGHYMLQGASSML

NOP2

361

P46087
MLMNYSSATEFYLLG

OR9A4

1

Q8NGU2
NALSAMLAYLGMATG

SLC39A6

661

Q13433
YLGLQMGYKALGMLL

SLCO2A1

606

Q92959
GMLTYGVYLGLLQMQ

UNC93B1

71

Q9H1C4
SLLGMLFGAYLMALA

SLC52A1

346

Q9NWF4
YYRSNMADMLYNLGL

TMTC2

521

Q8N394
YMPGGDLVNLMSNYD

ROCK2

171

O75116
NMGMYEYNGKSGYRL

PLCB1

636

Q9NQ66
DVGAYMLMYKGANRT

PRKDC

3851

P78527
LLMGVFSMYTGLIYN

ATP6V0A1

451

Q93050
RGVLGSTAMMLIYYA

SLC35G1

136

Q2M3R5
YNTILLMDGNMGAYI

TMEM117

126

Q9H0C3
MSARGDFLNYALSLM

UBR5

1911

O95071
GRSSVMAEYGLYGAM

VSX2

211

P58304
MAEYGLYGAMVRHSI

VSX2

216

P58304
AQLLDYGDMMLNRGS

KIAA0319

111

Q5VV43
VYRAAAMLNMTGSGY

GRIN1

231

Q05586