Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	ADCY4 ADCY6 MOCS1	8.98e-05	25	70	3	GO:0016849
GeneOntologyCellularComponent	keratohyalin granule	FLG HRNR FLG2	3.90e-07	5	72	3	GO:0036457
GeneOntologyCellularComponent	cornified envelope	FLG RPTN PKP3 HRNR FLG2	3.99e-06	69	72	5	GO:0001533
Domain	S_100	FLG RPTN CRNN HRNR FLG2	4.50e-08	27	69	5	PF01023
Domain	S100_Ca-bd_sub	FLG RPTN CRNN HRNR FLG2	5.46e-08	28	69	5	IPR013787
Domain	S_100	FLG RPTN CRNN HRNR FLG2	5.46e-08	28	69	5	SM01394
Domain	S100_CABP	FLG RPTN HRNR FLG2	2.81e-06	27	69	4	PS00303
Domain	S100/CaBP-9k_CS	FLG RPTN HRNR FLG2	3.27e-06	28	69	4	IPR001751
Domain	Filaggrin	FLG FLG2	1.35e-05	2	69	2	IPR003303
Domain	Nxph	NXPH1 NXPH2	8.03e-05	4	69	2	IPR010450
Domain	Adcy_conserved_dom	ADCY4 ADCY6	2.00e-04	6	69	2	IPR009398
Domain	DUF1053	ADCY4 ADCY6	2.00e-04	6	69	2	PF06327
Domain	NXPH/NXPE	NXPH1 NXPH2	3.71e-04	8	69	2	IPR026845
Domain	AC_N	ADCY4 ADCY6	3.71e-04	8	69	2	IPR032628
Domain	Adcy	ADCY4 ADCY6	3.71e-04	8	69	2	IPR030672
Domain	Neurexophilin	NXPH1 NXPH2	3.71e-04	8	69	2	PF06312
Domain	AC_N	ADCY4 ADCY6	3.71e-04	8	69	2	PF16214
Domain	EF_Hand_1_Ca_BS	FLG RPTN CRNN HRNR FLG2	4.72e-04	175	69	5	IPR018247
Domain	Ubiquitin-rel_dom	PIK3CA RAPGEF5 PTPN21 PLEKHG5 ARAF	5.93e-04	184	69	5	IPR029071
Domain	EF_HAND_1	FLG RPTN CRNN HRNR FLG2	9.44e-04	204	69	5	PS00018
Domain	SIAH-type	ST18 PDZRN4	1.56e-03	16	69	2	IPR013323
Domain	EF_HAND_2	FLG RPTN CRNN HRNR FLG2	1.64e-03	231	69	5	PS50222
Domain	EF_hand_dom	FLG RPTN CRNN HRNR FLG2	1.67e-03	232	69	5	IPR002048
Domain	A/G_cyclase_CS	ADCY4 ADCY6	1.76e-03	17	69	2	IPR018297
Domain	Nucleotide_cyclase	ADCY4 ADCY6	1.98e-03	18	69	2	IPR029787
Domain	-	ADCY4 ADCY6	1.98e-03	18	69	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	ADCY4 ADCY6	2.21e-03	19	69	2	PS00452
Domain	Guanylate_cyc	ADCY4 ADCY6	2.21e-03	19	69	2	PF00211
Domain	GUANYLATE_CYCLASE_2	ADCY4 ADCY6	2.21e-03	19	69	2	PS50125
Domain	A/G_cyclase	ADCY4 ADCY6	2.21e-03	19	69	2	IPR001054
Domain	CYCc	ADCY4 ADCY6	2.21e-03	19	69	2	SM00044
Domain	-	FLG RPTN CRNN HRNR FLG2	2.78e-03	261	69	5	1.10.238.10
Domain	PAS	NCOA3 PDE8B	3.82e-03	25	69	2	PF00989
Domain	PAS_fold	NCOA3 PDE8B	3.82e-03	25	69	2	IPR013767
Domain	EF-hand-dom_pair	FLG RPTN CRNN HRNR FLG2	4.17e-03	287	69	5	IPR011992
Domain	LRRNT	PKD1 LRRTM3 RTN4RL2	5.71e-03	98	69	3	IPR000372
Domain	LRRNT	PKD1 LRRTM3 RTN4RL2	5.71e-03	98	69	3	SM00013
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	FLG HRNR FLG2	8.51e-09	3	72	3	23403047
Pubmed	Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene.	ALX1 RAPGEF5 TENM1 EBF1	5.09e-07	31	72	4	27798109
Pubmed	Tolvaptan plus pasireotide shows enhanced efficacy in a PKD1 model.	PKD1 ADCY6	4.23e-06	2	72	2	24994926
Pubmed	Heterologous up-regulation of the histamine H1 receptor by M3 muscarinic receptor-mediated activation of H1-receptor gene transcription.	HRH1 CHRM3	4.23e-06	2	72	2	17637176
Pubmed	Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease.	PKD1 ADCY6	4.23e-06	2	72	2	24158982
Pubmed	Targeted sequencing of a specific gene panel detects a high frequency of ARID1A and PIK3CA mutations in ovarian clear cell carcinoma.	PIK3CA ARID1A	4.23e-06	2	72	2	30851247
Pubmed	The detection of tumor location and lymph node metastasis by aberrant NXPH1 and NXPH2 expressions in pancreatic ductal adenocarcinomas.	NXPH1 NXPH2	4.23e-06	2	72	2	27817196
Pubmed	Atopic Dermatitis Susceptibility Variants in Filaggrin Hitchhike Hornerin Selective Sweep.	FLG HRNR	4.23e-06	2	72	2	27678121
Pubmed	Expression and significance of EBV, ARID1A and PIK3CA in gastric carcinoma.	PIK3CA ARID1A	4.23e-06	2	72	2	30747208
Pubmed	Phosphatidylinositol 3-kinase and protein kinase D1 specifically cooperate to negatively regulate the insulin-like growth factor signaling pathway.	PIK3CA PKD1	4.23e-06	2	72	2	22227580
Pubmed	Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations.	PIK3CA ARID1A	4.23e-06	2	72	2	22157930
Pubmed	Coexistent ARID1A-PIK3CA mutations are associated with immune-related pathways in luminal breast cancer.	PIK3CA ARID1A	4.23e-06	2	72	2	38017109
Pubmed	Altered Expression of Genes Encoding Cornulin and Repetin in Atopic Dermatitis.	RPTN CRNN	4.23e-06	2	72	2	28219068
Pubmed	Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin.	FLG FLG2	4.23e-06	2	72	2	24813994
Pubmed	Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.	ADCY4 PTPRQ ADCY6	4.67e-06	16	72	3	17567809
Pubmed	Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.	FLG HRNR FLG2	1.10e-05	21	72	3	19601998
Pubmed	SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.	NCOA3 HRNR FLG2 CRTC2	1.10e-05	66	72	4	36095012
Pubmed	Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer.	PIK3CA ARID1A	1.27e-05	3	72	2	23702729
Pubmed	Loss of HDAC-Mediated Repression and Gain of NF-κB Activation Underlie Cytokine Induction in ARID1A- and PIK3CA-Mutation-Driven Ovarian Cancer.	PIK3CA ARID1A	1.27e-05	3	72	2	27681437
Pubmed	DNA Methylation Profiles of Ovarian Clear Cell Carcinoma.	PIK3CA ARID1A	1.27e-05	3	72	2	34697060
Pubmed	Clinicopathologic Significance of HNF-1β, AIRD1A, and PIK3CA Expression in Ovarian Clear Cell Carcinoma: A Tissue Microarray Study of 130 Cases.	PIK3CA ARID1A	1.27e-05	3	72	2	26945423
Pubmed	GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.	FLG FLG2	1.27e-05	3	72	2	28928464
Pubmed	Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.	FLG FLG2	1.27e-05	3	72	2	32437351
Pubmed	ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion.	PIK3CA ARID1A	1.27e-05	3	72	2	31391455
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TCF20 RAPGEF5 HIPK1 PPP1R9A ST18 ADCY6 MADD	2.19e-05	407	72	7	12693553
Pubmed	Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.	PIK3CA ARID1A	2.53e-05	4	72	2	25625625
Pubmed	Beyond conventional chemotherapy: Emerging molecular targeted and immunotherapy strategies in urothelial carcinoma.	PIK3CA ARID1A	2.53e-05	4	72	2	26138514
Pubmed	Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer.	PIK3CA ARID1A	2.53e-05	4	72	2	26334097
Pubmed	Role of protein kinase C-dependent A-kinase anchoring proteins in lysophosphatidic acid-induced cAMP signaling in human diploid fibroblasts.	ADCY4 ADCY6	2.53e-05	4	72	2	17081159
Pubmed	Arid1a inactivation in an Apc- and Pten-defective mouse ovarian cancer model enhances epithelial differentiation and prolongs survival.	PIK3CA ARID1A	2.53e-05	4	72	2	26279473
Pubmed	Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.	UBR4 KPRP HRNR FLG2	2.87e-05	84	72	4	29563501
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	NCOA3 TCF20 PKP3 DLX6 CRTC2	3.71e-05	180	72	5	35198878
Pubmed	Structure and evolution of neurexophilin.	NXPH1 NXPH2	4.21e-05	5	72	2	8699246
Pubmed	Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.	ADCY4 ADCY6	4.21e-05	5	72	2	21228062
Pubmed	Targeted Exome Sequencing of the Cancer Genome in Patients with Very High-risk Bladder Cancer.	PIK3CA ARID1A	4.21e-05	5	72	2	27520487
Pubmed	Mammalian adenylyl cyclase family members are randomly located on different chromosomes.	ADCY4 ADCY6	4.21e-05	5	72	2	7959689
Pubmed	Neurexophilins form a conserved family of neuropeptide-like glycoproteins.	NXPH1 NXPH2	4.21e-05	5	72	2	9570794
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	GLO1 UBR4 DBNL HLA-E KPRP HRNR FLG2 DNAJB14	5.77e-05	647	72	8	26618866
Pubmed	Thioredoxin interacting protein (Txnip) forms redox sensitive high molecular weight nucleoprotein complexes.	FLG PIK3CA HRNR	5.78e-05	36	72	3	31669268
Pubmed	Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.	FLG FLG2	6.31e-05	6	72	2	27304082
Pubmed	Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse.	ADCY4 ADCY6	6.31e-05	6	72	2	7766992
Pubmed	Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.	ADCY4 ADCY6	6.31e-05	6	72	2	11549699
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TCF20 EXPH5 SRGAP1 DBNL PTPN21 ARAF MADD CRTC2 SAMD4A	7.07e-05	861	72	9	36931259
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	FLG FAM120B TCF20 NRXN2 SLTM HRNR FLG2 ARID1A CWC22 AFF4	7.60e-05	1082	72	10	38697112
Pubmed	Differential expression of adenylyl cyclase mRNAs in lacrimal glands of NZB/NZW and NOD pre-autoimmune mice.	ADCY4 ADCY6	8.82e-05	7	72	2	12613887
Pubmed	Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.	NXPH1 NXPH2	8.82e-05	7	72	2	9856994
Pubmed	Association of signaling proteins with a nonmitogenic heterodimeric complex composed of epidermal growth factor receptor and kinase-inactive p185c-neu.	PIK3CA RAPGEF5	8.82e-05	7	72	2	8561895
Pubmed	Frizzled6 deficiency disrupts the differentiation process of nail development.	RPTN HRNR	8.82e-05	7	72	2	23439395
Pubmed	Interaction network of human early embryonic transcription factors.	NCOA3 TCF20 KPRP HRNR FLG2 ARID1A	9.03e-05	351	72	6	38297188
Pubmed	A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication.	NCOA3 GLO1 UBR4 PKD1 HERC4	9.19e-05	218	72	5	19460752
Pubmed	The locus controlling liver GM1(NeuGc) expression is mapped 1 cM centromeric to H-2K.	GLO1 HLA-E	1.17e-04	8	72	2	3334724
Pubmed	DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.	FLG PKP3 KPRP HRNR FLG2	1.39e-04	238	72	5	35864588
Pubmed	Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.	ADCY4 ADCY6	1.51e-04	9	72	2	9417641
Pubmed	Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.	ADCY4 ADCY6	1.51e-04	9	72	2	12503609
Pubmed	Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein.	PIK3CA ARAF	1.51e-04	9	72	2	11969417
Pubmed	Role of the calcium modulated cyclases in the development of the retinal projections.	ADCY4 ADCY6	1.51e-04	9	72	2	17229090
Pubmed	Purification and characterization of a soluble form of mammalian adenylyl cyclase.	ADCY4 ADCY6	1.88e-04	10	72	2	8663304
Pubmed	Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.	ADCY4 ADCY6	1.88e-04	10	72	2	16615126
Pubmed	Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.	ADCY4 ADCY6	1.88e-04	10	72	2	11884542
Pubmed	EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.	HRNR FLG2 MOCS1	1.96e-04	54	72	3	35474131
Pubmed	Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.	ADCY4 ADCY6	2.30e-04	11	72	2	11299302
Pubmed	Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.	ADCY4 ADCY6	2.30e-04	11	72	2	10089566
Pubmed	gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.	ADCY4 ADCY6	2.30e-04	11	72	2	10808179
Pubmed	Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program.	NCOA3 ARID1A	2.30e-04	11	72	2	18003620
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	PKP3 UBR4 KPRP ZDBF2 FLG2	2.57e-04	272	72	5	31010829
Pubmed	Expression of adenylyl cyclase mRNAs in the denervated and in the developing mouse skeletal muscle.	ADCY4 ADCY6	2.75e-04	12	72	2	9611134
Pubmed	LncRNA SAMD12-AS1 promotes cell proliferation and inhibits apoptosis by interacting with NPM1.	FLG HRNR	2.75e-04	12	72	2	31406141
Pubmed	HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.	ADCY4 ADCY6	2.75e-04	12	72	2	10807185
Pubmed	A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.	PKP3 HRNR FLG2	2.95e-04	62	72	3	26644517
Pubmed	Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice.	KPRP HRNR FLG2	3.24e-04	64	72	3	36636478
Pubmed	Assessment of splice variant-specific functions of desmocollin 1 in the skin.	RPTN PKP3	3.25e-04	13	72	2	14673151
Pubmed	Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).	PDE8B HRNR FLG2	3.39e-04	65	72	3	32120844
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	NCOA3 ALX1 TCF20 UBR4 MUC16 ZDBF2 ARID1A	3.55e-04	638	72	7	31182584
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	NCOA3 ALX1 TCF20 PKP3 ARID1A CRTC2	3.74e-04	457	72	6	32344865
Pubmed	Electrophoretic analysis of liver neuraminidase-1 variation in mice and additional evidence concerning the location of NEU-1.	GLO1 HLA-E	3.78e-04	14	72	2	3745925
Pubmed	Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.	ADCY4 ADCY6	3.78e-04	14	72	2	14993377
Pubmed	PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.	FLG HRNR	3.78e-04	14	72	2	29178343
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	NRXN2 SLTM GABRQ GRIK4 CHRM3	4.03e-04	300	72	5	19086053
Pubmed	cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.	ADCY4 ADCY6	4.36e-04	15	72	2	2165385
Pubmed	Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action.	PIK3CA HLA-E	4.36e-04	15	72	2	20702582
Pubmed	A neurogenomics approach to gene expression analysis in the developing brain.	NRXN2 PKD1 ADCY6 MADD	4.38e-04	170	72	4	15582152
Pubmed	HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway.	PIK3CA HLA-E	4.98e-04	16	72	2	11289809
Pubmed	TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination.	HRNR FLG2	4.98e-04	16	72	2	31823782
Pubmed	Localization of a mouse heat shock Hsp70 gene within the H-2 complex.	GLO1 HLA-E	5.63e-04	17	72	2	1978715
Pubmed	Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.	NCOA3 TCF20 ARID1A	5.79e-04	78	72	3	28611094
Pubmed	Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners.	WASF3 CRNN ARAF TMED4	6.14e-04	186	72	4	31540324
Pubmed	HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway.	PIK3CA HLA-E	6.33e-04	18	72	2	12526811
Pubmed	CLOCK is suggested to associate with comorbid alcohol use and depressive disorders.	NCOA3 GLO1	6.33e-04	18	72	2	20180986
Pubmed	NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.	NCOA3 GLO1	6.33e-04	18	72	2	19470168
Pubmed	Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.	PLEKHG6 PLEKHG5	6.33e-04	18	72	2	12799088
Pubmed	Ebf1 controls early cell differentiation in the embryonic striatum.	DLX6 EBF1	6.33e-04	18	72	2	10556054
Pubmed	Genetic variants associated with disordered eating.	FLG CRNN FLG2	6.94e-04	83	72	3	23568457
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	NCOA3 TCF20 ARID1A	6.94e-04	83	72	3	28794006
Pubmed	Human transcription factor protein interaction networks.	FLG NCOA3 TCF20 GLO1 UBR4 DLX6 HRNR TAF5 FLG2 ARID1A	7.01e-04	1429	72	10	35140242
Pubmed	Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption.	NCOA3 GLO1	7.06e-04	19	72	2	20554694
Pubmed	Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality.	PPP1R9A DLX6	7.84e-04	20	72	2	16341224
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NCOA3 TCF20 PPP1R9A UBR4 TAF5 TMEM132B ITIH4 AFF4	8.40e-04	963	72	8	28671696
Pubmed	The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.	GLO1 SLTM HRNR CWC22	8.50e-04	203	72	4	35012549
Pubmed	Murine candidate bleomycin induced pulmonary fibrosis susceptibility genes identified by gene expression and sequence analysis of linkage regions.	GLO1 HLA-E	8.65e-04	21	72	2	15937080
Pubmed	TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.	FLG HRNR FLG2	9.07e-04	91	72	3	34445801
Cytoband	1q21.3	FLG RPTN KPRP HRNR FLG2 CRTC2	3.28e-08	117	72	6	1q21.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	FLG RPTN CRNN KPRP HRNR FLG2 CRTC2	3.49e-06	404	72	7	chr1q21
Cytoband	10q21.3	LRRTM3 HERC4	1.32e-03	34	72	2	10q21.3
Cytoband	7p13	DBNL TMED4	1.73e-03	39	72	2	7p13
Cytoband	11q22.3	EXPH5 GRIK4	2.20e-03	44	72	2	11q22.3
Cytoband	Ensembl 112 genes in cytogenetic band chr7p13	DBNL TMED4	3.17e-03	53	72	2	chr7p13
GeneFamily	EF-hand domain containing\|S100 fused type protein family	FLG RPTN CRNN HRNR FLG2	1.99e-12	7	47	5	1350
GeneFamily	EF-hand domain containing	FLG RPTN CRNN HRNR FLG2	2.53e-04	219	47	5	863
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY4 ADCY6	2.94e-04	10	47	2	53
ToppCell	TCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue-6\|TCGA-Bladder / Sample_Type by Project: Shred V9	FLG IL36A RPTN CRNN KPRP FLG2	6.02e-08	127	72	6	d61b71572eab8a850ee8ce54323fb247525006e5
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLG PLEKHG6 IL36A RPTN CRNN MUC16	4.01e-07	175	72	6	8252ddc2ca95071381f0354aefb70c4714828491
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLG PLEKHG6 IL36A RPTN CRNN MUC16	4.01e-07	175	72	6	8ccf60fc469059d7aaf4e6ce54159db2962e0060
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Nts\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NXPH1 FIBCD1 GABRQ ST18 NXPH2	1.99e-06	127	72	5	ace2944328529fa029ee56c7ad3b0f283511d3bb
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal-Interneuron\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	NXPH1 DLX6 NXPH2 PDZRN4	3.56e-06	64	72	4	fefabdf8d72a8f3caf78eb79d759edb475bdb2ad
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZNF23 NXPH1 ZDBF2 DLX6 PDZRN4	7.59e-06	167	72	5	743df5908c1ceb43b34b240d9f9649f30f4142fa
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell-mesothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZNF23 NXPH1 ZDBF2 DLX6 PDZRN4	7.59e-06	167	72	5	1adb566f98af0109c8cc6e36033b89651e2c75e7
ToppCell	facs-Trachea-nan-24m-Mesenchymal-smooth_muscle_cell_of_trachea\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF23 RAPGEF5 ZDBF2 ST18 ITIH4	7.82e-06	168	72	5	6c7b490b6c844d0ea4c07edfc24c02284f9533c4
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Interneuron\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	NXPH1 DLX6 NXPH2 PDZRN4	7.86e-06	78	72	4	8ad496ccbffb62a50f195c3789a95d8c80e2272d
ToppCell	lymphoid-T_cell-pro-T_cell\|World / Lineage, cell class and subclass	PIK3CA HIPK1 TENM1 ZDBF2	8.70e-06	80	72	4	9bd3ad5029eb84efcdbf08fe268c29fa9b0b302b
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW10-Neuronal-GABAergic_neurons\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	RPTN NXPH1 DLX6 TMEM132B PDZRN4	9.53e-06	175	72	5	d4ff1f197ad4086286e86817cbff24fa718293fc
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 PIK3CA HIPK1 TAF5 MADD	9.79e-06	176	72	5	8e89471f838ea81235256cc2470f1c12c9b75f8a
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.09e-05	180	72	5	97e0dcb7cfbba60a782824c5e23995058609fcd4
ToppCell	metastatic_Lymph_Node-B_lymphocytes-GC_B_cells_in_the_LZ\|metastatic_Lymph_Node / Location, Cell class and cell subclass	LAT2 RAPGEF5 PDE8B DBNL EBF1	1.18e-05	183	72	5	30db83f600e2c4ad3af68a8a946673f4352a2807
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLG IL36A RPTN CRNN GABRQ	1.25e-05	185	72	5	f3fbc3096f85397a959cee17c3c4fcf2d511f3d5
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	TCF20 EXPH5 WASF3 CHRM3 PDZRN4	1.35e-05	188	72	5	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NRXN2 PDE8B LRRTM3 RTN4RL2 TMEM132B	1.42e-05	190	72	5	6c7e1086c0a274cd5527c3104106e372811c9905
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.49e-05	192	72	5	56b021c297a21dff357531f21e2464f85186106d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.49e-05	192	72	5	28eb3a5728e8901bcb5ba12f6b009f41b065fa37
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 IL36A RAPGEF5 HLA-E EBF1	1.53e-05	193	72	5	807fa1443b3c883cb318c71f4fca3c41d58f4910
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HRH1 EBF1 CHRM3	1.53e-05	193	72	5	0b328f725f6feba263783eaca60c142e80df90f3
ToppCell	CF-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	NCOA3 LAT2 PIK3CA EBF1 SAMD4A	1.53e-05	193	72	5	7ebf20344a9a154fd2cffa281526867fcf0aded3
ToppCell	IPF-Stromal-Pericyte\|Stromal / Disease state, Lineage and Cell class	ADCY4 RAPGEF5 PDE8B EBF1 MOCS1	1.57e-05	194	72	5	3892b188f424ffb80f3c75a1b6709a21c1e1601d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.57e-05	194	72	5	b0c15e7e4bcf30856fb628dedd7ba82df33489f5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.61e-05	195	72	5	77e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.65e-05	196	72	5	8ad8efb631164b46f0c082572270188e5ead20bf
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.65e-05	196	72	5	b8f89a50114932c08fc5daac4b549adfe9df8e66
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NXPH1 TENM1 DLX6 NXPH2 SAMD4A	1.65e-05	196	72	5	7af6c5147ac859353504d19727dbe24f63a29dd4
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.65e-05	196	72	5	9606ea7e42f707e69ea891b3521037613b9675f5
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.65e-05	196	72	5	d0ff1082898d2db47c88d2678466514e9e9193d3
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	FLG IL36A PKP3 CRNN MUC16	1.69e-05	197	72	5	ac9c0c25cfeaabd53d332982c73fc6c47b0c6478
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	FLG IL36A PKP3 CRNN MUC16	1.69e-05	197	72	5	b57d2e3413ef6dd1da56c45087926f2f3eab876c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.73e-05	198	72	5	07701c73137947ed4a27e225975329235bbb8734
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.73e-05	198	72	5	31ba87552be97c9b78c9e82f98e96699ccb19824
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.73e-05	198	72	5	1378c6d4ceb84b42fdd6556be3296df7a8059e6e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.73e-05	198	72	5	451003a21162eeae90739fdb502bb50b362d80c8
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.73e-05	198	72	5	953630dbe3154b1b102b87de0feca2cbf124eabe
ToppCell	COVID-19-kidney-AQP1+PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.73e-05	198	72	5	8689090bce9ab6e8f122426a404037e572c6713b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.73e-05	198	72	5	440af8f90c7afa1c07000806bcf9110b70f489fb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.73e-05	198	72	5	fa84bf8533d1b91d2c2bcf06b710670605072b89
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.73e-05	198	72	5	0a172c6d997c7cfbad34b56e80121bd104dee67d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.73e-05	198	72	5	8e45551224fbb30c0658ad47dd98335ecf165437
ToppCell	distal-mesenchymal-Pericyte-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PDE8B FIBCD1 C1QTNF2 EBF1 MOCS1	1.77e-05	199	72	5	e72ac7a00405cde06293d7adac7dc40eb0cf87ba
ToppCell	Kidney-Keratinocytes\|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.	EXPH5 PKP3 KPRP PLEKHG5 TMEM132B	1.81e-05	200	72	5	41d83faa9f45ee7ea2ab19be8ecc6d2c5ac7fe5d
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	NRXN2 TENM1 DLX6 NXPH2 PDZRN4	1.81e-05	200	72	5	bad32a95b759fad509401b07bc96a56687c2a592
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RAPGEF5 SRGAP1 PPP1R9A MUC16 CHRM3	1.81e-05	200	72	5	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 RAPGEF5 HLA-E EBF1 CHRM3	1.81e-05	200	72	5	93e13937ec74418a697c37d56f57509fb2154780
ToppCell	distal-1-mesenchymal-Pericyte\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PDE8B FIBCD1 C1QTNF2 EBF1 MOCS1	1.81e-05	200	72	5	ff205afda57b9267016f0c937445da1b0266af9b
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RAPGEF5 SRGAP1 PPP1R9A MUC16 CHRM3	1.81e-05	200	72	5	0eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	NRXN2 NXPH1 DLX6 NXPH2 PDZRN4	1.81e-05	200	72	5	c6bbd33bca86ac7a76a7ba704b3e141237d04549
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	NXPH1 FIBCD1 GABRQ DLX6	2.19e-05	101	72	4	cf52c93f523c5f25bd45519a1444ce7bd1d8b577
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRQ TENM1 KPRP ST18	8.98e-05	145	72	4	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	NXPH1 FIBCD1 DLX6 NXPH2	8.98e-05	145	72	4	8b13b576fd2e6e33ccb146860a91a53cee0cdd4d
ToppCell	COVID-19-kidney-Mito-rich_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADCY4 RAPGEF5 EBF1 CHRM3	8.98e-05	145	72	4	afed661aef990edb8e7012ab67ace56443520c9f
ToppCell	PND01-03-samps-Epithelial-Alveolar_epithelial-AT1_-_meso\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	EXPH5 PKP3 FLG2 RTN4RL2	1.02e-04	150	72	4	6a13e4c4b9c9e54a5016573a37132465ec1c8f99
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac1_Htr1d\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NXPH1 FIBCD1 C1QTNF2 NXPH2	1.16e-04	155	72	4	79264ff283e36a059040a5aa9fe7337be694cb52
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FIBCD1 CRNN GRIK4 RTN4RL2	1.16e-04	155	72	4	72a19a9ecfd13f6769c4b447d3ce01a855ec6ec7
ToppCell	5'-Adult-Appendix-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAT2 RAPGEF5 PTPRQ EBF1	1.19e-04	156	72	4	203ef22eb76bd2b829b027c30af0557080f4006c
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-Pro-B\|bone_marrow / Manually curated celltypes from each tissue	LAT2 RAPGEF5 EBF1 CHRM3	1.19e-04	156	72	4	b093dbba6662e4fffc8aa577587b77f64ac44b56
ToppCell	COVID-19-lung-Mesothelial\|lung / Disease (COVID-19 only), tissue and cell type	PTPRQ MUC16 LRRTM3 NXPH2	1.19e-04	156	72	4	e1f563869b3bf997eaa2e756e31b53db1a478903
ToppCell	TCGA-Stomach-Solid_Tissue_Normal-Stomach_normal_tissue-Stomach_normal_tissue-4\|TCGA-Stomach / Sample_Type by Project: Shred V9	FLG IL36A CRNN KPRP	1.22e-04	157	72	4	2553ebf3e48de5bd184e77bd61114faa5a1d95ed
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Fibin\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NXPH1 GABRQ C1QTNF2 DLX6	1.22e-04	157	72	4	741d79c10cb87fa7f14080c6fccb1553c3a20bad
ToppCell	COVID-19-kidney-Epithelial_(EC)\|kidney / Disease (COVID-19 only), tissue and cell type	ADCY4 RAPGEF5 FIBCD1 EBF1	1.31e-04	160	72	4	0d4880f85565d8c540c94a8f8109147b3029279a
ToppCell	RV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	RAPGEF5 DLX6 EBF1 PDZRN4	1.31e-04	160	72	4	29c9b4770d0e73d59cffc7937b179484c76b6dcc
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Pdlim5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NXPH1 FIBCD1 DLX6 CHRM3	1.34e-04	161	72	4	bf70be1de418615b5442ec684552551edaf1f072
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PIK3CA NXPH1 DLX6 NXPH2	1.34e-04	161	72	4	b81b346309f3facbfbebd91cae4c5b33c7bd24ef
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPRQ TENM1 KPRP ST18	1.38e-04	162	72	4	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal-GABAergic_neurons\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	NXPH1 DLX6 NXPH2 PDZRN4	1.44e-04	164	72	4	4d7b2d0980fb4f47721fa2891151e2bd892ccb91
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Interneuron\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	NXPH1 DLX6 PDZRN4	1.46e-04	63	72	3	c10d344bf32a091deb79e1f128f7dd5e9f4abaa3
ToppCell	Bronchial_Brush-Epithelial-Goblet_2\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	PLEKHG6 FIBCD1 RTN4RL2 SAMD4A	1.51e-04	166	72	4	8ac0a769be886d16642e7e6334471ebadd1a426b
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPTN FIBCD1 RTN4RL2 NXPH2	1.55e-04	167	72	4	3dfec2fcc36caa6e394efae5e540a6fa28759977
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPTN FIBCD1 RTN4RL2 NXPH2	1.55e-04	167	72	4	95b3b5ba3414729f0460a26a0deca48de0cbe33e
ToppCell	Bronchial_Brush-Epithelial-Goblet_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	PLEKHG6 FIBCD1 RTN4RL2 SAMD4A	1.55e-04	167	72	4	806d1c00c137da0c5f042adf866873eb6dd4bb27
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPTN FIBCD1 RTN4RL2 NXPH2	1.55e-04	167	72	4	9480739587d51e67a281778b9bddd7b5ffc3ad92
ToppCell	Control\|World / group, cell type (main and fine annotations)	RAPGEF5 EXPH5 PPP1R9A CHRM3	1.58e-04	168	72	4	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	368C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|368C / Donor, Lineage, Cell class and subclass (all cells)	ZNF23 EXPH5 TENM1 C1QTNF2	1.62e-04	169	72	4	1d5ce2c97f7ef7bdc9f861938077a9aa31d84db6
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NXPH1 GABRQ EBF1 PDZRN4	1.62e-04	169	72	4	bb43abad2c049b7f4d307737347290e01b3339a3
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PIK3CA NXPH1 DLX6 ARAF	1.62e-04	169	72	4	c135d7ae0490d0024e0f4bd8c4ad42f6674a61da
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NXPH1 GABRQ EBF1 PDZRN4	1.62e-04	169	72	4	5f18e3f40a5b1b167903f37516ec8181e889c7c5
ToppCell	368C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	ZNF23 EXPH5 TENM1 C1QTNF2	1.62e-04	169	72	4	58098f8801ca941aeddafb47e88ab0df8b9edb57
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NXPH1 GABRQ EBF1 PDZRN4	1.62e-04	169	72	4	8bfa2d3bb541d02f55d7c95b8fd156c8403befca
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLG IL36A RPTN CRNN	1.66e-04	170	72	4	13a225e32132e9717debb0d64d7c28ada974c3e6
ToppCell	T_cells-CD56_bright_CD16-_NK_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	LAT2 PPP1R9A HRNR RTN4RL2	1.73e-04	172	72	4	980e8b9e1ceeb0dec9eb9ef95c139e5ffe99b6e4
ToppCell	TCGA-Head_and_Esophagus\|World / Sample_Type by Project: Shred V9	IL36A RPTN CRNN KPRP	1.73e-04	172	72	4	eb18aa179db1818f408c38e442ecfed8582d7dbc
ToppCell	facs-Heart-LV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN2 PDE8B RTN4RL2 ADCY6	1.77e-04	173	72	4	d78397e65e997ddb995111a810f0e2a4f67d0765
ToppCell	Adult-Mesenchymal-pericyte_cell-D175\|Adult / Lineage, Cell type, age group and donor	PDE8B EBF1 MOCS1 PDZRN4	1.77e-04	173	72	4	fd6653d6be9ca6ac36798590694efe03cb758c67
ToppCell	facs-Heart-LV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN2 PDE8B RTN4RL2 ADCY6	1.77e-04	173	72	4	3c852ffe22f4a5b632463086b08c669310684e80
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EXPH5 PTPRQ RTN4RL2 PDZRN4	1.81e-04	174	72	4	0df738309b7b6e77675ea74e7a87e66601b0073d
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADCY4 HLA-E EBF1 CHRM3	1.81e-04	174	72	4	18ab52d8bbca0507fee220e0c4fc765fc47dda34
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	LRRTM3 EBF1 ADCY6 MOCS1	1.81e-04	174	72	4	015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	WASF3 PTPRQ PTPN21 SAMD4A	1.81e-04	174	72	4	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	facs-Skin-nan-24m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WASF3 LRRTM3 ITIH4 PDZRN4	1.85e-04	175	72	4	f1166b567bca80dac3abe90c3dc544c831006640
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAT2 EXPH5 PKP3 PLEKHG5	1.89e-04	176	72	4	8e4600efeea095a92178cfd26d7c58db7dfc0c80
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EXPH5 PTPRQ RTN4RL2 PDZRN4	1.89e-04	176	72	4	03d194c9814e12802cd932afade69e868814cb78
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EXPH5 PTPRQ RTN4RL2 PDZRN4	1.89e-04	176	72	4	ed7ba2a3af3b060dec98b60f09f96000a67f7e63
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RAPGEF5 LRRTM3 EBF1 PDZRN4	1.93e-04	177	72	4	4943d040eee0f9dceaddc7498171281d170e271f
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EXPH5 PTPRQ RTN4RL2 PDZRN4	1.93e-04	177	72	4	64fbf799e7b0c4003b2f486cc41b0f7e7c11ea0c
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HRH1 GRIK4 RTN4RL2 PDZRN4	1.93e-04	177	72	4	921783ed0fe20294d2f384d9136924b679df01bb
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RAPGEF5 LRRTM3 EBF1 PDZRN4	1.93e-04	177	72	4	3f2272b577c862dba8ccfb41184054bbd0ace6f5
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EXPH5 GRIK4 RTN4RL2 PDZRN4	1.93e-04	177	72	4	f30d757ee8db7e10d547498dab6560473c6ed7c0
Drug	Depixol	ADCY4 HRH1 GRIK4 ADCY6	3.32e-06	33	71	4	CID000017011
Disease	necrotizing enterocolitis	ADCY4 TCF20 NXPH1	3.75e-05	27	71	3	EFO_0003928
Disease	type 2 diabetes mellitus (implicated_via_orthology)	GLO1 AFF4 MADD CRTC2	1.22e-04	105	71	4	DOID:9352 (implicated_via_orthology)
Disease	body weights and measures, parental genotype effect measurement	EBF1 CHRM3	5.10e-04	14	71	2	EFO_0004324, EFO_0005939
Disease	Adenocarcinoma Of Esophagus	PIK3CA ARID1A	5.10e-04	14	71	2	C0279628
Disease	forced expiratory volume, response to bronchodilator	NRXN2 NXPH1 GRIK4 EBF1 TMEM132B CHRM3	7.12e-04	445	71	6	EFO_0004314, GO_0097366
Disease	Bipolar Disorder	RAPGEF5 GLO1 DBNL HLA-E GRIK4 ITIH4	1.02e-03	477	71	6	C0005586
Disease	Autism Spectrum Disorders	NRXN2 GABRQ LRRTM3	1.14e-03	85	71	3	C1510586
Disease	Schizophrenia	NRXN2 PIK3CA GLO1 HLA-E HRH1 GABRQ GRIK4 PTPN21	1.25e-03	883	71	8	C0036341
Disease	Nasopharyngeal carcinoma	PIK3CA ARID1A	1.28e-03	22	71	2	C2931822
Disease	paracentral lobule volume measurement	FAM120B NXPH1	1.65e-03	25	71	2	EFO_0010317
Disease	breast cancer (implicated_via_orthology)	NCOA3 PIK3CA	1.65e-03	25	71	2	DOID:1612 (implicated_via_orthology)
Disease	isthmus cingulate cortex volume measurement	TCF20 PTCHD3	1.79e-03	26	71	2	EFO_0010310
Disease	Dupuytren Contracture	ADCY4 WASF3 EBF1	2.27e-03	108	71	3	EFO_0004229

Protein segments in the cluster

Peptide	Gene	Start	Entry
PRTDSSYTGFSNHQN	ALX1	256	Q15699
SGLNASTYDQVGRSH	ADCY6	1041	O43306
HFGSYNVSRAAGNFS	CHRM3	36	P20309
QGSRPESTNNFHSLY	ADCY4	251	Q8NFM4
QASSAVRDSGHRGYS	FLG	2026	P20930
TGGRQGSHYDQAQDS	FLG	2111	P20930
RSGETSGHSGSFLYQ	FLG	3051	P20930
GRSGSFLYQVSTHEQ	FLG	3381	P20930
QSYHNSSAAAQTRGD	DLX6	11	P56179
SSGQRHDRESYNNSG	AFF4	146	Q9UHB7
GESRNRNVHSGSTFF	ITIH4	611	Q14624
TFSVYFRHNSTGLGN	NXPH2	141	O95156
RARGNSSSNHLYGVA	RTN4RL2	321	Q86UN3
TLHDGGFRNYNTSID	PDZRN4	701	Q6ZMN7
GQSERHQRYSTGKNT	LUZP4	296	Q9P127
HDSYGNQFSTQGTPS	ARID1A	1336	O14497
NSLYVNGFTHRSSGL	MUC16	13121	Q8WXI7
SGNQEGSQKRYHRSS	FLG2	171	Q5D862
FGQHESRSRQSSYGQ	FLG2	531	Q5D862
FGQHESRSGQSSYGQ	FLG2	606	Q5D862
SQSSGYGQHGSRQTS	FLG2	626	Q5D862
FGQHESRSGHSSYGQ	FLG2	681	Q5D862
SGFGQHESRSGQSSY	FLG2	756	Q5D862
QYSGFGQHESRSHQS	FLG2	906	Q5D862
GFGQHESRSSQSNYG	FLG2	986	Q5D862
ESRSSQSNYGQHGSG	FLG2	991	Q5D862
QTTGFGQHRSSSGQY	FLG2	1021	Q5D862
QYESRSRQSSYGQHG	FLG2	1066	Q5D862
SRQSSYGQHGSGSSQ	FLG2	1071	Q5D862
GKSSGFAQHEYRSGQ	FLG2	1136	Q5D862
TLRGYYNQSEAGSHT	HLA-E	101	P13747
SYTPRFSQHVSGNRA	MADD	791	Q8WXG6
QHQFATQSYIGSSRG	HIPK1	1176	Q86Z02
TSEQARHSYGVRFNG	GABRQ	456	Q9UN88
HSGSRSDEDRYQNGA	CWC22	861	Q9HCG8
GQYRIRTFDANTGNH	C1QTNF2	216	Q9BXJ5
ETQSYHNGNSDPRGF	GLO1	111	Q04760
DSGDNSQTEPHSFRY	PDE8B	396	O95263
GDQSFSHYSSPQNCG	HERC4	371	Q5GLZ8
FQRDFSGQHNSYSGQ	HRNR	161	Q86YZ3
HQESRSGQSSGYGQH	HRNR	586	Q86YZ3
GAGSHSSAQRADYFA	NRXN2	541	Q9P2S2
RTPLNYGSRTQFGHF	EXPH5	231	Q8NEV8
HYEGSSHRQSQQGSR	CRNN	131	Q9UBG3
SREAGFSYSHAGLSN	PIK3CA	501	P42336
GSGSFQRHYTSRADS	MOCS1	441	Q9NZB8
VRSYTRFGHGNQVSS	PTPRQ	776	Q9UMZ3
NGRIRNGSVYSAHST	PTPN21	386	Q16825
ETYGGRHRASAQSTA	PLEKHG6	21	Q3KR16
RQQFYHSVQDLSGGS	ARAF	151	P10398
LFYHSQSGRNSTFES	IL36A	106	Q9UHA7
HSFSNGRAGYSQQHQ	DNAJB14	216	Q8TBM8
YTRSSHYGGSLPNVN	CRTC2	61	Q53ET0
QGFTRNSSSVSPHGY	EBF1	456	Q9UH73
TSNLNGQYLRGAHAS	FIBCD1	416	Q8N539
TQGSYGSFTEQHRSR	KPRP	236	Q5T749
GSSRDYVAVNRSHGQ	HRH1	316	P35367
HGGSSMTFFQNSRYQ	GRIK4	671	Q16099
SGANYSFHKESGRFQ	DBNL	136	Q9UJU6
YHRTGSGYSRSSQGQ	FAM120B	876	Q96EK7
QGHFTTNDSYRFSAS	PTCHD3	186	Q3KNS1
TQSQPAANHTYASRG	PKD1	1171	P98161
ASSRYQNFSKGSRHG	LAT2	91	Q9GZY6
QNFSKGSRHGSEEAY	LAT2	96	Q9GZY6
HPNSNYVATGSADRT	TAF5	636	Q15542
RRSTSSGQYTGFNDH	SRGAP1	936	Q7Z6B7
GHRPDTQSRVNGSFY	TMEM132B	356	Q14DG7
SYNQLHSLGSEQFRG	LRRTM3	141	Q86VH5
NGTFSVYFRHNSTGQ	NXPH1	146	P58417
DFYNNSISSNGSHLG	NCOA3	811	Q9Y6Q9
TDARFGHGSDYSRQQ	SLTM	751	Q9NWH9
GHGSDYSRQQNRFND	SLTM	756	Q9NWH9
YFTFSRQGSGEHTAN	RAPGEF5	371	Q92565
SNSANEVFHYGSLRG	ST6GALNAC6	61	Q969X2
HSDYGFTISRQDGSF	TENM1	911	Q9UKZ4
HTQSPGRASSYSYGQ	ST18	551	O60284
RGQYHTLQAGFSSRS	PKP3	81	Q9Y446
HSAVGAYTFQASGQA	PLEKHG5	656	O94827
PDNRLSQSVYHGASS	WASF3	216	Q9UPY6
PARYGFNSHQGTSDS	ZDBF2	2111	Q9HCK1
LRVGQFGQHYQSSAS	TCF20	226	Q9UGU0
SYNSPLHFGNGTRLT	TRBJ1-6	1	A0A0J9YWX3
SRQYGSEGRFTFTSH	TMED4	91	Q7Z7H5
AGRRTYHTRSQGDNN	USP3	201	Q9Y6I4
GNGFSCSSAYITHQR	ZNF23	286	P17027
TDRQGQSSHYGQTDR	RPTN	286	Q6XPR3
QTDRQGQSSHYSQPD	RPTN	321	Q6XPR3
GQSSHYSQPDRQGQS	RPTN	326	Q6XPR3
RQGQSSHYGQTDRQG	RPTN	456	Q6XPR3
GQSSHYGQTDRQGQS	RPTN	506	Q6XPR3
DRQGQSSHYGQTDRQ	RPTN	551	Q6XPR3
AISSSRRAGGEHYQN	UBR4	391	Q5T4S7
QNRGRSDSVDYGQTH	SAMD4A	161	Q9UPU9
TRDNNTGATYPHLNF	TYSND1	501	Q2T9J0
FERSVHESGQNNRYS	PPP1R9A	146	Q9ULJ8