Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

SLIT2 EGF MEGF6 DLL4 TKT SLIT1 NOTCH2NLA LRP4 HABP2 PRKCSH LTBP3 CUBN ADGRE1 NOTCH2NLC FBN3 NOTCH4

5.49e-107496116GO:0005509
GeneOntologyMolecularFunctionNotch binding

DLL4 NOTCH2NLA NOTCH4

7.53e-0527613GO:0005112
GeneOntologyMolecularFunctionhistone H3K14 acetyltransferase activity

KAT6A KAT6B

3.26e-049612GO:0036408
GeneOntologyMolecularFunctionRoundabout binding

SLIT2 SLIT1

5.94e-0412612GO:0048495
GeneOntologyMolecularFunctionhistone H3 acetyltransferase activity

KAT6A KAT6B

9.40e-0415612GO:0010484
GeneOntologyBiologicalProcessepithelium development

SLIT2 ZNF703 ASXL1 HOXC13 EGF DLL4 GLI1 KRT40 WT1 LRP4 LAMA5 TRIM71 MESP2 LCE1E NOTCH4

1.44e-0514696015GO:0060429
GeneOntologyBiologicalProcessbranching morphogenesis of an epithelial tube

SLIT2 EGF DLL4 WT1 LAMA5 NOTCH4

2.36e-05198606GO:0048754
GeneOntologyBiologicalProcesschemorepulsion involved in embryonic olfactory bulb interneuron precursor migration

SLIT2 SLIT1

2.49e-053602GO:0021834
GeneOntologyBiologicalProcessgland development

SLIT2 ZNF703 ASXL1 EGF GLI1 WT1 LAMA5 PRKCSH NOTCH4

3.15e-05558609GO:0048732
GeneOntologyBiologicalProcessdorsal/ventral axon guidance

SLIT2 SLIT1

4.97e-054602GO:0033563
GeneOntologyBiologicalProcessanimal organ morphogenesis

SLIT2 ASXL1 HOXC13 DLL4 GLI1 SLIT1 KAT6A WT1 NTNG1 LRP4 LAMA5 MESP2 LTBP3

5.82e-0512696013GO:0009887
GeneOntologyBiologicalProcessmorphogenesis of a branching epithelium

SLIT2 EGF DLL4 WT1 LAMA5 NOTCH4

6.29e-05236606GO:0061138
GeneOntologyBiologicalProcessembryonic olfactory bulb interneuron precursor migration

SLIT2 SLIT1

8.27e-055602GO:0021831
GeneOntologyBiologicalProcessmorphogenesis of a branching structure

SLIT2 EGF DLL4 WT1 LAMA5 NOTCH4

1.03e-04258606GO:0001763
GeneOntologyBiologicalProcessembryo development

SLIT2 GGNBP2 DLL4 GLI1 KAT6A WT1 LRP4 LAMA5 TRIM71 MESP2 PRKCSH RESP18 CUBN

2.04e-0414376013GO:0009790
GeneOntologyBiologicalProcessepithelial tube morphogenesis

SLIT2 EGF DLL4 WT1 LAMA5 TRIM71 NOTCH4

2.13e-04421607GO:0060562
GeneOntologyBiologicalProcessaorta morphogenesis

DLL4 KAT6A NOTCH4

2.31e-0441603GO:0035909
GeneOntologyBiologicalProcessheart development

SLIT2 ASXL1 ANK2 DLL4 GLI1 DUSP6 KAT6A WT1 MESP2

3.18e-04757609GO:0007507
GeneOntologyBiologicalProcessregulation of Notch signaling pathway

DLL4 NOTCH2NLA NOTCH2NLC NOTCH4

3.40e-04114604GO:0008593
GeneOntologyBiologicalProcessNotch signaling pathway

DLL4 NOTCH2NLA MESP2 NOTCH2NLC NOTCH4

3.62e-04210605GO:0007219
GeneOntologyBiologicalProcesstangential migration from the subventricular zone to the olfactory bulb

SLIT2 SLIT1

3.69e-0410602GO:0022028
GeneOntologyBiologicalProcessolfactory bulb interneuron development

SLIT2 SLIT1

4.50e-0411602GO:0021891
GeneOntologyBiologicalProcessregionalization

HOXC13 DLL4 GLI1 WT1 LRP4 LAMA5 MESP2

4.59e-04478607GO:0003002
GeneOntologyBiologicalProcesspositive regulation of Notch signaling pathway

DLL4 NOTCH2NLA NOTCH2NLC

4.94e-0453603GO:0045747
GeneOntologyCellularComponentextracellular matrix

SLIT2 IL16 ZAN MEGF6 EMID1 LAMA5 MUC5B LTBP3 FBN3

9.88e-05656609GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

SLIT2 IL16 ZAN MEGF6 EMID1 LAMA5 MUC5B LTBP3 FBN3

1.01e-04658609GO:0030312
GeneOntologyCellularComponentMOZ/MORF histone acetyltransferase complex

KAT6A KAT6B

1.69e-047602GO:0070776
GeneOntologyCellularComponentH3 histone acetyltransferase complex

KAT6A KAT6B

2.24e-048602GO:0070775
DomainEGF

SLIT2 EGF ZAN MEGF6 DLL4 SLIT1 NOTCH2NLA NTNG1 LRP4 LAMA5 HABP2 LTBP3 CUBN ADGRE1 NOTCH2NLC FBN3 NOTCH4 PEAR1

2.63e-202356118SM00181
DomainEGF-like_dom

SLIT2 EGF ZAN MEGF6 DLL4 SLIT1 NOTCH2NLA NTNG1 LRP4 LAMA5 HABP2 LTBP3 CUBN ADGRE1 NOTCH2NLC FBN3 NOTCH4 PEAR1

7.51e-202496118IPR000742
DomainEGF_1

SLIT2 EGF ZAN MEGF6 DLL4 SLIT1 NOTCH2NLA NTNG1 LRP4 LAMA5 HABP2 LTBP3 CUBN ADGRE1 NOTCH2NLC FBN3 NOTCH4 PEAR1

1.16e-192556118PS00022
DomainEGF-like_CS

SLIT2 EGF ZAN MEGF6 DLL4 SLIT1 NOTCH2NLA NTNG1 LRP4 LAMA5 HABP2 LTBP3 CUBN ADGRE1 NOTCH2NLC FBN3 NOTCH4 PEAR1

1.76e-192616118IPR013032
DomainEGF_2

SLIT2 EGF ZAN MEGF6 DLL4 SLIT1 NOTCH2NLA NTNG1 LRP4 LAMA5 HABP2 LTBP3 CUBN ADGRE1 NOTCH2NLC FBN3 NOTCH4 PEAR1

2.31e-192656118PS01186
DomainEGF_3

SLIT2 EGF ZAN MEGF6 DLL4 SLIT1 NOTCH2NLA NTNG1 LRP4 HABP2 LTBP3 CUBN ADGRE1 NOTCH2NLC FBN3 NOTCH4 PEAR1

9.11e-192356117PS50026
DomainEGF_CA

SLIT2 EGF MEGF6 DLL4 SLIT1 NOTCH2NLA LRP4 HABP2 LTBP3 CUBN ADGRE1 NOTCH2NLC FBN3 NOTCH4

2.08e-181226114SM00179
DomainEGF-like_Ca-bd_dom

SLIT2 EGF MEGF6 DLL4 SLIT1 NOTCH2NLA LRP4 HABP2 LTBP3 CUBN ADGRE1 NOTCH2NLC FBN3 NOTCH4

2.63e-181246114IPR001881
DomainEGF-type_Asp/Asn_hydroxyl_site

SLIT2 EGF MEGF6 DLL4 SLIT1 NOTCH2NLA LRP4 LTBP3 CUBN ADGRE1 NOTCH2NLC FBN3 NOTCH4

1.55e-171066113IPR000152
DomainEGF

SLIT2 EGF ZAN MEGF6 DLL4 SLIT1 NOTCH2NLA LRP4 HABP2 CUBN NOTCH2NLC FBN3 NOTCH4

1.59e-161266113PF00008
DomainEGF_Ca-bd_CS

SLIT2 EGF MEGF6 SLIT1 NOTCH2NLA LRP4 LTBP3 CUBN ADGRE1 NOTCH2NLC FBN3 NOTCH4

2.69e-16976112IPR018097
DomainEGF_CA

SLIT2 EGF MEGF6 SLIT1 NOTCH2NLA LRP4 LTBP3 CUBN ADGRE1 NOTCH2NLC FBN3 NOTCH4

3.48e-16996112PS01187
DomainASX_HYDROXYL

SLIT2 EGF MEGF6 DLL4 NOTCH2NLA LRP4 LTBP3 CUBN ADGRE1 NOTCH2NLC FBN3 NOTCH4

3.94e-161006112PS00010
DomainEGF_CA

EGF MEGF6 NOTCH2NLA LRP4 LTBP3 CUBN ADGRE1 NOTCH2NLC FBN3 NOTCH4

1.86e-13866110PF07645
DomainGrowth_fac_rcpt_

EGF MEGF6 DLL4 SLIT1 LRP4 LAMA5 LTBP3 CUBN ADGRE1 FBN3 NOTCH4

2.82e-121566111IPR009030
DomainhEGF

SLIT2 MEGF6 SLIT1 LTBP3 FBN3 NOTCH4

3.36e-1028616PF12661
DomaincEGF

LRP4 LTBP3 ADGRE1 FBN3

1.46e-0626614IPR026823
DomaincEGF

LRP4 LTBP3 ADGRE1 FBN3

1.46e-0626614PF12662
DomainLaminin_EGF

MEGF6 NTNG1 LAMA5 PEAR1

5.00e-0635614PF00053
DomainEGF_Lam

MEGF6 NTNG1 LAMA5 PEAR1

5.00e-0635614SM00180
DomainLaminin_EGF

MEGF6 NTNG1 LAMA5 PEAR1

6.99e-0638614IPR002049
DomainEMI_domain

MEGF6 EMID1 PEAR1

1.80e-0516613IPR011489
DomainEMI

MEGF6 EMID1 PEAR1

2.18e-0517613PS51041
DomainCTCK_1

SLIT2 SLIT1 MUC5B

2.61e-0518613PS01185
DomainRESP18

PTPRN RESP18

3.14e-053612PF14948
DomainRESP18_dom

PTPRN RESP18

3.14e-053612IPR029403
DomainCT

SLIT2 SLIT1 MUC5B

4.88e-0522613SM00041
DomainCys_knot_C

SLIT2 SLIT1 MUC5B

7.24e-0525613IPR006207
DomainCTCK_2

SLIT2 SLIT1 MUC5B

7.24e-0525613PS01225
DomainMOZ_SAS

KAT6A KAT6B

1.04e-045612PF01853
DomainHAT_MYST-type

KAT6A KAT6B

1.04e-045612IPR002717
DomainMYST_HAT

KAT6A KAT6B

1.04e-045612PS51726
DomainTB

LTBP3 FBN3

2.18e-047612PF00683
DomainZnf_PHD

ASXL1 KAT6A DPF2 KAT6B

2.23e-0491614IPR001965
DomainLAM_G_DOMAIN

SLIT2 SLIT1 LAMA5

2.58e-0438613PS50025
DomainZF_PHD_2

ASXL1 KAT6A DPF2 KAT6B

2.63e-0495614PS50016
DomainZF_PHD_1

ASXL1 KAT6A DPF2 KAT6B

2.73e-0496614PS01359
Domain-

EGF LRP4 TRIM71

2.79e-04396132.120.10.30
Domain-

LTBP3 FBN3

2.90e-0486123.90.290.10
DomainLaminin_G_2

SLIT2 SLIT1 LAMA5

3.00e-0440613PF02210
DomainTB

LTBP3 FBN3

3.72e-049612PS51364
DomainTB_dom

LTBP3 FBN3

3.72e-049612IPR017878
DomainLamG

SLIT2 SLIT1 LAMA5

3.99e-0444613SM00282
Domain6-blade_b-propeller_TolB-like

EGF LRP4 TRIM71

4.55e-0446613IPR011042
DomainFol_N

SLIT2 SLIT1

5.66e-0411612IPR003645
DomainFOLN

SLIT2 SLIT1

5.66e-0411612SM00274
DomainTIL

ZAN MUC5B

6.78e-0412612PF01826
DomainC8

ZAN MUC5B

6.78e-0412612PF08742
DomainUnchr_dom_Cys-rich

ZAN MUC5B

8.00e-0413612IPR014853
DomainH15

KAT6A KAT6B

8.00e-0413612SM00526
DomainC8

ZAN MUC5B

8.00e-0413612SM00832
DomainH15

KAT6A KAT6B

8.00e-0413612PS51504
DomainLaminin_G

SLIT2 SLIT1 LAMA5

9.00e-0458613IPR001791
DomainHistone_H1/H5_H15

KAT6A KAT6B

9.31e-0414612IPR005818
DomainTIL_dom

ZAN MUC5B

9.31e-0414612IPR002919
DomainLdl_recept_b

EGF LRP4

9.31e-0414612PF00058
DomainLDLRB

EGF LRP4

9.31e-0414612PS51120
DomainLY

EGF LRP4

1.07e-0315612SM00135
DomainLDLR_classB_rpt

EGF LRP4

1.07e-0315612IPR000033
DomainVWD

ZAN MUC5B

1.22e-0316612SM00216
DomainVWF_type-D

ZAN MUC5B

1.22e-0316612IPR001846
DomainLaminin_N

NTNG1 LAMA5

1.22e-0316612IPR008211
DomainLAMININ_NTER

NTNG1 LAMA5

1.22e-0316612PS51117
DomainVWFD

ZAN MUC5B

1.22e-0316612PS51233
DomainLaminin_N

NTNG1 LAMA5

1.22e-0316612PF00055
DomainVWD

ZAN MUC5B

1.22e-0316612PF00094
DomainLamNT

NTNG1 LAMA5

1.22e-0316612SM00136
DomainVWC_out

ZAN MUC5B

1.73e-0319612SM00215
DomainPHD

KAT6A DPF2 KAT6B

1.89e-0375613PF00628
DomainZnf_PHD-finger

KAT6A DPF2 KAT6B

2.20e-0379613IPR019787
DomainPHD

KAT6A DPF2 KAT6B

3.08e-0389613SM00249
Domain-

SLIT2 SLIT1 LAMA5

3.71e-03956132.60.120.200
Pubmed

Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

MEGF6 SLIT1 LRP4

4.72e-0796339693030
Pubmed

Dual role for LIM-homeodomain gene Lhx2 in the formation of the lateral olfactory tract.

SLIT2 SLIT1 NTNG1

1.23e-061263317329426
Pubmed

Slit-roundabout signaling regulates the development of the cardiac systemic venous return and pericardium.

SLIT2 SLIT1 WT1

2.54e-061563323255421
Pubmed

Breast cancer stem cells: something out of notching?

DLL4 NOTCH4

3.23e-06263221045140
Pubmed

Permissive corridor and diffusible gradients direct medial ganglionic eminence cell migration to the neocortex.

SLIT2 SLIT1

3.23e-06263212515855
Pubmed

Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes.

SLIT2 SLIT1

3.23e-06263212200164
Pubmed

Regulation of KAT6 Acetyltransferases and Their Roles in Cell Cycle Progression, Stem Cell Maintenance, and Human Disease.

KAT6A KAT6B

3.23e-06263227185879
Pubmed

Directional guidance of neuronal migration in the olfactory system by the protein Slit.

SLIT2 SLIT1

3.23e-06263210432110
Pubmed

Steerable-filter based quantification of axonal populations at the developing optic chiasm reveal significant defects in Slit2(-/-) as well as Slit1(-/-)Slit2(-/-) embryos.

SLIT2 SLIT1

3.23e-06263223320558
Pubmed

Slit1 and slit2 proteins control the development of the lateral olfactory tract.

SLIT2 SLIT1

3.23e-06263212097499
Pubmed

ERα status of invasive ductal breast carcinoma as a result of regulatory interactions between lysine deacetylases KAT6A and KAT6B.

KAT6A KAT6B

3.23e-06263239505971
Pubmed

WT1 induction of mitogen-activated protein kinase phosphatase 3 represents a novel mechanism of growth suppression.

DUSP6 WT1

3.23e-06263218644985
Pubmed

Notch signaling in primary endothelial cells.

DLL4 NOTCH4

3.23e-06263212814948
Pubmed

The double PHD finger domain of MOZ/MYST3 induces α-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification.

KAT6A KAT6B

3.23e-06263224150941
Pubmed

The role of floor plate contact in the elaboration of contralateral commissural projections within the embryonic mouse spinal cord.

SLIT2 GLI1 SLIT1

4.53e-061863316854408
Pubmed

Loss of endogenous thymosin β4 accelerates glomerular disease.

GLI1 WT1 ADGRE1

4.53e-061863327575556
Pubmed

Coronary arteries form by developmental reprogramming of venous cells.

DLL4 WT1 NOTCH4

5.38e-061963320336138
Pubmed

Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves.

SLIT2 DLL4 SLIT1

5.38e-061963325691540
Pubmed

Gli3 is required in Emx1+ progenitors for the development of the corpus callosum.

SLIT2 GLI1 SLIT1

7.36e-062163323396189
Pubmed

MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain.

KAT6A KAT6B

9.68e-06363236754959
Pubmed

Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain.

SLIT2 SLIT1

9.68e-06363216162649
Pubmed

Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis.

DUSP6 MESP2

9.68e-06363222744456
Pubmed

Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system.

SLIT2 SLIT1

9.68e-0636329813312
Pubmed

EGF/TGFβ1 co-stimulation of oral squamous cell carcinoma cells causes an epithelial-mesenchymal transition cell phenotype expressing laminin 332.

EGF LAMA5

9.68e-06363220819124
Pubmed

Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis.

SLIT2 WT1

9.68e-06363210349621
Pubmed

A molecular mechanism for the heparan sulfate dependence of slit-robo signaling.

SLIT2 SLIT1

9.68e-06363217062560
Pubmed

Conserved modularity and potential for alternate splicing in mouse and human Slit genes.

SLIT2 SLIT1

9.68e-06363212141424
Pubmed

Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits.

SLIT2 SLIT1

9.68e-06363216840550
Pubmed

Biochemical, biophysical, and functional properties of ICA512/IA-2 RESP18 homology domain.

PTPRN RESP18

9.68e-06363226836020
Pubmed

Delta-like 4/Notch pathway is differentially regulated in benign and malignant thyroid tissues.

DLL4 NOTCH4

9.68e-06363222066479
Pubmed

Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2.

KAT6A DPF2

9.68e-06363227775714
Pubmed

Tandem PHD fingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin.

KAT6A KAT6B

9.68e-06363223063713
Pubmed

The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions.

DLL4 NOTCH4

9.68e-06363216951162
Pubmed

New neurons follow the flow of cerebrospinal fluid in the adult brain.

SLIT2 SLIT1

9.68e-06363216410488
Pubmed

Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain.

SLIT2 SLIT1

9.68e-06363210364234
Pubmed

Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion.

SLIT2 SLIT1

9.68e-06363224065825
Pubmed

The vascular delta-like ligand-4 (DLL4)-Notch4 signaling correlates with angiogenesis in primary glioblastoma: an immunohistochemical study.

DLL4 NOTCH4

9.68e-06363226472724
Pubmed

Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.

WT1 CUBN ADGRE1

1.80e-052863328847650
Pubmed

The interaction of ETV6 (TEL) and TIP60 requires a functional histone acetyltransferase domain in TIP60.

KAT6A KAT6B

1.93e-05463217980166
Pubmed

Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex.

NOTCH2NLA NOTCH2NLC

1.93e-05463229561261
Pubmed

The mouse BP-1 gene: structure, chromosomal localization, and regulation of expression by type I interferons and interleukin-7.

EGF ANK2

1.93e-0546328660964
Pubmed

Multiple roles for slits in the control of cell migration in the rostral migratory stream.

SLIT2 SLIT1

1.93e-05463214960623
Pubmed

Contralateral migration of oculomotor neurons is regulated by Slit/Robo signaling.

SLIT2 SLIT1

1.93e-05463227770832
Pubmed

Slits contribute to the guidance of retinal ganglion cell axons in the mammalian optic tract.

SLIT2 SLIT1

1.93e-05463216828733
Pubmed

Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties.

DLL4 NOTCH4

1.93e-05463236376768
Pubmed

Evolution of Human Brain Size-Associated NOTCH2NL Genes Proceeds toward Reduced Protein Levels.

NOTCH2NLA NOTCH2NLC

1.93e-05463232330268
Pubmed

Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF).

KAT6A KAT6B

1.93e-05463221880731
Pubmed

The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance.

SLIT2 SLIT1

1.93e-05463210433822
Pubmed

Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.

DLL4 NOTCH4

3.22e-05563221726900
Pubmed

Posttranslational acetylation of the human immunodeficiency virus type 1 integrase carboxyl-terminal domain is dispensable for viral replication.

KAT6A KAT6B

3.22e-05563217182677
Pubmed

Slit and robo: expression patterns in lung development.

SLIT2 SLIT1

3.22e-05563212609596
Pubmed

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis.

NOTCH2NLA NOTCH2NLC

3.22e-05563229856954
Pubmed

Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation.

NOTCH2NLA NOTCH2NLC

3.22e-05563229856955
Pubmed

Origin and characterization of alpha smooth muscle actin-positive cells during murine lung development.

GLI1 WT1

3.22e-05563228370670
Pubmed

MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2.

KAT6A KAT6B

3.22e-05563211965546
Pubmed

On the topographic targeting of basal vomeronasal axons through Slit-mediated chemorepulsion.

SLIT2 SLIT1

3.22e-05563212954717
Pubmed

Expression of the vertebrate Slit gene family and their putative receptors, the Robo genes, in the developing murine kidney.

SLIT2 WT1

3.22e-05563210842075
Pubmed

Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4).

DLL4 NOTCH4

3.22e-05563223675950
Pubmed

Multiple modes of Lrp4 function in modulation of Wnt/β-catenin signaling during tooth development.

GLI1 LRP4

3.22e-05563228694256
Pubmed

Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding.

SLIT2 SLIT1

3.22e-05563215207848
Pubmed

CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS.

DLL4 NOTCH4

3.22e-05563217576775
Pubmed

Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization.

SLIT2 SLIT1

3.22e-05563225894826
Pubmed

Expression patterns of Slit and Robo family members in adult mouse spinal cord and peripheral nervous system.

SLIT2 SLIT1

3.22e-05563228234971
Pubmed

Slit1 is specifically expressed in the primary and secondary enamel knots during molar tooth cusp formation.

SLIT2 SLIT1

3.22e-05563211520671
Pubmed

Emergent growth cone responses to combinations of Slit1 and Netrin 1 in thalamocortical axon topography.

SLIT2 SLIT1

3.22e-05563222000108
Pubmed

Slit proteins regulate distinct aspects of retinal ganglion cell axon guidance within dorsal and ventral retina.

SLIT2 SLIT1

3.22e-05563216885222
Pubmed

Midbrain dopaminergic axons are guided longitudinally through the diencephalon by Slit/Robo signals.

SLIT2 SLIT1

3.22e-05563221118670
Pubmed

Slit proteins are not dominant chemorepellents for olfactory tract and spinal motor axons.

SLIT2 SLIT1

3.22e-05563211748139
Pubmed

Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.

DLL4 WT1 NOTCH4

3.26e-053463321311046
Pubmed

Notch signaling regulates smooth muscle differentiation of epicardium-derived cells.

DLL4 WT1 NOTCH4

3.56e-053563321252157
Pubmed

A study on Notch signaling in human breast cancer.

DLL4 NOTCH4

4.82e-05663217822320
Pubmed

SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium.

SLIT2 SLIT1

4.82e-05663218829537
Pubmed

Slit2 is a repellent for retinal ganglion cell axons.

SLIT2 SLIT1

4.82e-05663210864954
Pubmed

Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice.

EGF ANK2

4.82e-0566321716634
Pubmed

Autocrine/juxtaparacrine regulation of axon fasciculation by Slit-Robo signaling.

SLIT2 SLIT1

4.82e-05663222306607
Pubmed

Nephronectin is required to maintain right lung lobar separation during embryonic development.

WT1 LAMA5

4.82e-05663236719987
Pubmed

Slit/Robo-mediated chemorepulsion of vagal sensory axons in the fetal gut.

SLIT2 SLIT1

4.82e-05663223161783
Pubmed

Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system.

SLIT2 SLIT1

4.82e-05663211804570
Pubmed

Slit antagonizes netrin-1 attractive effects during the migration of inferior olivary neurons.

SLIT2 SLIT1

4.82e-05663212051827
Pubmed

The role of Slit-Robo signaling in the generation, migration and morphological differentiation of cortical interneurons.

SLIT2 SLIT1

4.82e-05663218054781
Pubmed

Robo1 and robo2 control the development of the lateral olfactory tract.

SLIT2 SLIT1

4.82e-05663217360927
Pubmed

Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis.

SLIT2 SLIT1

4.82e-05663216439476
Pubmed

Pioneer longitudinal axons navigate using floor plate and Slit/Robo signals.

SLIT2 SLIT1

4.82e-05663218842816
Pubmed

Robo2 Receptor Gates the Anatomical Divergence of Neurons Derived From a Common Precursor Origin.

SLIT2 SLIT1

4.82e-05663234249921
Pubmed

Notch4 reveals a novel mechanism regulating Notch signal transduction.

DLL4 NOTCH4

4.82e-05663224667410
Pubmed

Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry.

GLI1 WT1

4.82e-05663224130328
Pubmed

Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.

DLL4 MUC5B NOTCH4

5.75e-054163322675208
Pubmed

VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels.

SLIT2 SLIT1

6.74e-05763228676569
Pubmed

Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.

KAT6A KAT6B

6.74e-05763218794358
Pubmed

Role of Asxl1 in kidney podocyte development via its interaction with Wtip.

ASXL1 WT1

6.74e-05763226385183
Pubmed

Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis.

DLL4 NOTCH4

6.74e-05763218952909
Pubmed

Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor.

ADGRE1 PEAR1

6.74e-05763219915564
Pubmed

ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development.

KAT6A WT1

6.74e-05763238446206
Pubmed

Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice.

WT1 ADGRE1

6.74e-05763215342464
Pubmed

Slit-Robo signals regulate pioneer axon pathfinding of the tract of the postoptic commissure in the mammalian forebrain.

SLIT2 SLIT1

6.74e-05763221688288
Pubmed

Slit molecules prevent entrance of trunk neural crest cells in developing gut.

SLIT2 SLIT1

6.74e-05763225490618
Pubmed

Islet architecture: A comparative study.

SLIT2 SLIT1

6.74e-05763220606719
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

SLIT2 MEGF6 SLIT1 NOTCH2NLA LAMA5 PRKCSH LTBP3

6.86e-0556063721653829
Pubmed

Pulmonary neuroendocrine cells function as airway sensors to control lung immune response.

SLIT2 SLIT1 ADGRE1

8.13e-054663326743624
Pubmed

Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.

SLIT2 ZNF703 SLIT1 NTNG1

8.29e-0512663416284245
InteractionHOXA1 interactions

SLIT2 ZNF703 MEGF6 SLIT1 KRT40 NOTCH2NLA LAMA5 LTBP3 AMMECR1 NR1D2

8.97e-083566010int:HOXA1
InteractionTRIM42 interactions

IL16 GLI1 SLIT1 KRT40 NOTCH2NLA LCE1E

5.32e-06149606int:TRIM42
GeneFamilyZinc fingers C2HC-type|PHD finger proteins|Lysine acetyltransferases

KAT6A KAT6B

4.55e-041636266
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

KAT6A KAT6B

5.14e-0417362486
GeneFamilyPHD finger proteins

KAT6A DPF2 KAT6B

7.56e-049036388
GeneFamilyHOXL subclass homeoboxes

HOXC13 EVX2

4.80e-0352362518
CoexpressionNABA_ECM_GLYCOPROTEINS

SLIT2 EMID1 SLIT1 NTNG1 LAMA5 LTBP3 FBN3

3.24e-07196607M3008
CoexpressionNABA_MATRISOME

SLIT2 IL16 EGF MEGF6 EMID1 SLIT1 NTNG1 LAMA5 MUC5B HABP2 LTBP3 FBN3

2.99e-0610266012M5889
CoexpressionNABA_CORE_MATRISOME

SLIT2 EMID1 SLIT1 NTNG1 LAMA5 LTBP3 FBN3

3.11e-06275607M5884
CoexpressionNABA_ECM_GLYCOPROTEINS

SLIT2 EMID1 SLIT1 NTNG1 LAMA5 LTBP3

5.00e-06191606MM17059
CoexpressionNABA_MATRISOME

SLIT2 IL16 EGF MEGF6 EMID1 SLIT1 NTNG1 LAMA5 MUC5B HABP2 LTBP3

1.57e-0510086011MM17056
CoexpressionBENPORATH_SUZ12_TARGETS

SLIT2 ZNF703 HOXC13 DLL4 DUSP6 SLIT1 NOTCH2NLA OTOP2 WT1 AMMECR1 CSMD3

2.00e-0510356011M9898
CoexpressionNABA_CORE_MATRISOME

SLIT2 EMID1 SLIT1 NTNG1 LAMA5 LTBP3

3.55e-05270606MM17057
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

SLIT2 MEGF6 GLI1 LTBP3 NOTCH4 PEAR1

2.49e-07188626c90669b51e1902fe7726555290c91c92a911df83
ToppCellremission-Non-classical_Monocyte|remission / disease stage, cell group and cell class

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1 NOTCH4

3.18e-07196626049d995986c20ce066bd64fcc2d2f1c2f8899883
ToppCellremission-Non-classical_Monocyte|World / disease stage, cell group and cell class

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1 NOTCH4

3.37e-071986261c170655070acca00520b7cf9c510a04c0a90a8f
ToppCelldroplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC14 EGF MEGF6 DLL4 LAMA5

5.08e-06179625a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZBTB46 DLL4 CUBN PLEKHG5 NOTCH4

5.65e-06183625ce8be9418b473ea94ec806edc7a2078cc30c1703
ToppCellMonocytes-Inflammatory_CD16+_macrophages|World / Immune cells in Kidney/Urine in Lupus Nephritis

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

7.14e-061926254be5c2c946337cd3e710137726358adca563f146
ToppCellhealthy_donor-Myeloid-Monocytic-CD16+_Monocyte|healthy_donor / Disease condition, Lineage, Cell class and subclass

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

7.50e-06194625ecf746ef1c5c4d6d9ca06a6d3e3778670b5700c2
ToppCellCOVID_vent-Myeloid-Monocytic-CD16+_Monocyte|COVID_vent / Disease condition, Lineage, Cell class and subclass

ZNF703 DUSP6 SIGLEC10 ADGRE1 NOTCH4

7.50e-06194625b133d3d198360269cc449a75d34c29be377d91e0
ToppCellAdult-Endothelial|Adult / Lineage, Cell type, age group and donor

ZBTB46 DLL4 EMID1 NOTCH4 PEAR1

7.50e-06194625963b3fbee0575af8379baa397ace65949eaf34f7
ToppCellControl-Myeloid-CD16_Mono|Control / Disease, Lineage and Cell Type

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

7.69e-06195625a37e75be248ff28f6647e4e690629f82c1fb7370
ToppCellMultiple_Sclerosis-Myeloid-CD16_Mono|Multiple_Sclerosis / Disease, Lineage and Cell Type

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

7.89e-0619662583011b56780295dff5ded57064b07dcd2f19ea26
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

8.28e-06198625cbbdd44dfa95370c0fbaa65ba71d86bfee0ea379
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

8.28e-061986253bc3dbd178043deadd7eef413b2761dc003abd6e
ToppCellHealthy-Non-classical_Monocyte|Healthy / disease group, cell group and cell class

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

8.28e-06198625394e5fa8998c46c6f7cd57b53f347d2029c75ae1
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

8.28e-061986259b47585653aaebd033c9b7bba93c7a7c35a4d60e
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

8.28e-061986258b5d30312bbcabc6911ff03e5028766d77203dff
ToppCellHealthy-Non-classical_Monocyte|World / disease group, cell group and cell class

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

8.28e-061986254fd27a9fb3758c94ed9f0a726296e92b0625da44
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

8.28e-061986257d8fade2583c07a33dd83057cbce08e9fc77987a
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

8.28e-06198625165d60b111a17d517a420c434733eefb98da240d
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

8.49e-0619962599eec995aa20ac22a8dd045382bd15a15db0b87a
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

8.49e-06199625aca9f75c690c6ed952bcbdc7e1e7eef7719f54ca
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

8.49e-061996253e09b3c2e2c57e5248981293020d2434e898e3e1
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

8.49e-06199625ae6b4b4557c6a9223acdee2a79bc780c5916d38a
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

8.49e-061996254eed28ef8c74d7131eeeabdd732a682d91e034dd
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

8.49e-06199625f234533254fd82b1ef2041e8405fe201d874018b
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF703 TKT DUSP6 SIGLEC10 ADGRE1

8.49e-06199625df946601b295be5419c09befbfa73f4314eef116
ToppCellGlobus_pallidus|World / BrainAtlas - Mouse McCarroll V32

EGF ZAN MEGF6 LTBP3

2.88e-0512662444b63f945d5bedf1a2ca1810e7e100276ea9dd89
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_Krt80|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLIT2 ZNF703 P2RX4 NTNG1

4.48e-0514162440ef6d792e11fe10963d64eb0b606b90556c1a70
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZBTB46 DLL4 EMID1 LRP4

7.32e-051606246215ac6123a295f3c2f033786602a57b2e2e1177
ToppCellfacs-Marrow-Granulocytes-18m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DUSP6 EMID1 SLIT1 AMMECR1

7.86e-051636247a04192710f55acf5a4681d5f09942358fdb02ff
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ASXL1 DLL4 CSMD3 FBN3

8.24e-05165624dc570154baed59ed109e5369589448e075ba66a9
ToppCellfacs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1F ZNF703 SLIT1 ADGRE1

8.84e-0516862404e168fe1d6f5f9e3d3bf9d7c13e800e3594868a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZBTB46 EMID1 WT1 PEAR1

9.25e-05170624876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZBTB46 EMID1 WT1 PEAR1

9.25e-051706241f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-CD141+_DCs|Myeloid_cells / Location, Cell class and cell subclass

ZBTB46 IL16 ZAN CUBN

9.68e-051726241215f61f115b042f84721b64c2ed1f48081535f1
ToppCellwk_15-18-Hematologic-Myeloid-Eosinophil|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ZAN SIGLEC10 MESP2 ADGRE1

9.90e-05173624a85cead231e03945fabbc7762540ad21fe4299df
ToppCellfacs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZBTB46 DLL4 PLEKHG5 NOTCH4

1.01e-04174624b1bcd5f4505d2ccef4183fcfbf1de81964b3f9e0
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P2RX4 EMID1 MESP2 PLEKHG5

1.08e-041776249b4c1ca5c6fca9a7a936dad49a04155903ef9c32
ToppCellfacs-Lung-EPCAM-18m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P2RX4 DLL4 DUSP6 LAMA5

1.08e-041776242433924dcb085ebbe2545d476ebd7ee68e6092fb
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-CD141+_DCs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

ZBTB46 IL16 ZAN CUBN

1.13e-0417962499894067e2c2a3ed53abdc5434410c3172693496
ToppCell3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DUSP6 EMID1 WT1 MESP2

1.13e-041796249dd8d19050223cdebec2579014892b759e5e9de8
ToppCellCOVID-19-kidney-PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ZBTB46 DLL4 DUSP6 NOTCH4

1.15e-04180624493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell368C-Endothelial_cells-Endothelial-E|368C / Donor, Lineage, Cell class and subclass (all cells)

DLL4 LAMA5 PLEKHG5 NOTCH4

1.15e-041806248ab16a0b9053bffc07b569a4f9e71749f56dde7e
ToppCell368C-Endothelial_cells-Endothelial-E-|368C / Donor, Lineage, Cell class and subclass (all cells)

DLL4 LAMA5 PLEKHG5 NOTCH4

1.15e-04180624394cd465b88429b70eebb2957480dffcbc51cfe7
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P2RX4 EMID1 LAMA5 PLEKHG5

1.15e-0418062441e8155cc7b3dac9d496e4077845ca6af1591a5c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZBTB46 EMID1 WT1 PEAR1

1.18e-04181624a2058d658f07ab6f0a28d2622f3090b4cde6f763
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZBTB46 EMID1 WT1 PEAR1

1.18e-04181624526e858a848470b6d2d5248788004d9735ed3add
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLIT2 ASXL1 CSMD3 FBN3

1.18e-0418162430729f0364f719c044712a51453e22dc2c1a232b
ToppCellE16.5-samps-Endothelial-Immature_fetal_endothelial-Intermediate_Endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

HOXC13 DLL4 PLEKHG5 NOTCH4

1.20e-04182624fec1caf867b1dc87b24504d895ee1a27df78062e
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EGF MEGF6 DLL4 LAMA5

1.23e-041836246f8f997ffc9eaebca2683de125b6069d07c07d26
ToppCellCOVID-19-kidney-Mito-rich_EC|kidney / Disease (COVID-19 only), tissue and cell type

ZBTB46 DLL4 EMID1 NOTCH4

1.23e-041836243c4153479fc4ab2d073d92cee120480015555914
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1F ZAN MUC5B CSMD3

1.25e-041846242cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Skin-Skin_Anagen-18m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLIT2 ZBTB46 ANK2 NTNG1

1.25e-04184624fea4fe648e9749177d0783443dc26a7df5807883
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1F ZAN MUC5B CSMD3

1.25e-04184624ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1F ZAN MUC5B CSMD3

1.25e-041846242b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Skin-Skin_Anagen-18m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLIT2 ZBTB46 ANK2 NTNG1

1.25e-0418462496a8a0a190bc293655fe7d80cbed8119c0da25f2
ToppCellfacs-Skin-Skin_Anagen-18m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLIT2 ZBTB46 ANK2 NTNG1

1.25e-04184624780eb72da43527f0c72effac3423ec7384f05f20
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P2RX4 EMID1 LAMA5 PLEKHG5

1.28e-041856245527fa9d2e0b2f3607602e18ba94de4e9bbc6824
ToppCellPBMC-Control-Hematopoietic|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

EGF PTPRN EMID1 PEAR1

1.28e-04185624c95c77d4302d7fff7fdef1774f15a93ba9ced61a
ToppCellPBMC-Control-Hematopoietic|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

EGF PTPRN EMID1 PEAR1

1.28e-0418562472a281ef246de5b30de1241d792c25bfae60e797
ToppCell356C-Endothelial_cells-Endothelial-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

DLL4 CUBN NOTCH4 PEAR1

1.31e-041866242e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell356C-Endothelial_cells-Endothelial-E|356C / Donor, Lineage, Cell class and subclass (all cells)

DLL4 CUBN NOTCH4 PEAR1

1.31e-04186624c3449e54454009973818fc1101933c6f0168258c
ToppCell3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IL16 DLL4 SCN4A NOTCH4

1.34e-0418762450d5730e2cd4951d3ad0641fc81ae9f6ddabafe7
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANK2 PTPRN SLIT1 NTNG1

1.36e-04188624bd091503f580dedab40e0996273101285d24b586
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZBTB46 DLL4 EMID1 NOTCH4

1.39e-04189624e60a3d6aa84788c29f23439f1c747431ea581bc3
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SLIT2 SLIT1 NTNG1 CSMD3

1.39e-04189624203c80030df08ae112f9ae4043709f455d87ce89
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF703 ANK2 EMID1 PEAR1

1.42e-04190624106862ef44fcaa0971c3ba0147d13eb08015ca77
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

SLIT2 IL16 ANK2 NTNG1

1.42e-041906243a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell10x5'-Lung-Myeloid_Monocytic-Nonclassical_monocytes|Lung / Manually curated celltypes from each tissue

ZNF703 SIGLEC10 ADGRE1 NOTCH4

1.45e-04191624a862a571625ab7238589ff201e5954f602c3bd7e
ToppCellCOVID-19-kidney-VWF+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ZBTB46 DLL4 DUSP6 NOTCH4

1.45e-041916242f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCellInfluenza_Severe-Non-classical_Monocyte|Influenza_Severe / Disease group and Cell class

ZNF703 SIGLEC10 ADGRE1 NOTCH4

1.45e-04191624197edf6feb1cfc71d88e532d74f77305a42a3486
ToppCell5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCDC14 DLL4 SLIT1 KRT40

1.45e-0419162454f07e4de61735051498846afb44b1798bed8144
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SLIT2 IL16 ANK2 NTNG1

1.45e-041916246688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SLIT2 IL16 ANK2 NTNG1

1.48e-0419262499ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell10x5'-Lung-Myeloid_Monocytic|Lung / Manually curated celltypes from each tissue

ZNF703 TKT DUSP6 ADGRE1

1.51e-04193624ebe6be10ef5de9e1da988e263106698d3db42fce
ToppCellnormal-na-Myeloid-non-classical_monocyte-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

ZNF703 TKT SIGLEC10 ADGRE1

1.51e-04193624053adc7ed9f997b503e12239a684bb9f5896e10c
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

SLIT2 IL16 ANK2 WT1

1.51e-041936249ab47b360bee1d4f1092c2269e58acebe9584021
ToppCellCOVID_non-vent-Myeloid-Monocytic-CD16+_Monocyte|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

ZNF703 DUSP6 SIGLEC10 ADGRE1

1.54e-041946241b4a17d58793e8889484fe592dce8ee1e8fe77a9
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANK2 PTPRN SLIT1 LINC01561

1.54e-0419462415224fb3e7ca5bd1fb8c41f8275842f737014095
ToppCellsevere_influenza-Non-classical_Monocyte|severe_influenza / disease group, cell group and cell class (v2)

ZNF703 SIGLEC10 ADGRE1 NOTCH4

1.54e-041946247630e223666fb65743e21e045478f687dd739a54
ToppCellmedial-Hematologic-Nonclassical_Monocyte|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ZNF703 TKT SIGLEC10 ADGRE1

1.54e-04194624ac203d388a3a3884e316dec0dcbd408e43c6ef6c
ToppCellmedial-2-Hematologic-Nonclassical_Monocyte|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ZNF703 TKT SIGLEC10 ADGRE1

1.54e-04194624202e5070728191c46161fa7d931f00be1c7559d4
ToppCellmedial-Hematologic-Nonclassical_Monocyte-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ZNF703 TKT SIGLEC10 ADGRE1

1.54e-04194624002cd317732fc6b0d9a72fb46199f71db5a638a7
ToppCellCOVID-19-kidney-Glomerular_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ZBTB46 DLL4 EMID1 NOTCH4

1.54e-04194624660535b492445063d965095a50e1e299ce04c50a
ToppCelldistal-Hematologic-Nonclassical_Monocyte|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ZNF703 TKT SIGLEC10 ADGRE1

1.57e-041956246f417bb464b8ae6a50bbab5db5a6d5760c02122f
ToppCellIIF-Myeloid-CD16_Mono|IIF / Disease, Lineage and Cell Type

ZNF703 TKT SIGLEC10 ADGRE1

1.57e-0419562487c1f52ab19b105bae3f315496c620c226a77a7f
ToppCelldistal-2-Hematologic-Nonclassical_Monocyte|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ZNF703 TKT SIGLEC10 ADGRE1

1.57e-0419562434bed73e4dae34b0f1076b7ff9dc7ea2096c1796
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZBTB46 DLL4 EMID1 NOTCH4

1.57e-0419562423ced69fd904f1d4114b1a7f99f4b5f65ea8824b
ToppCellcontrol-Myeloid-CD16_Monocytes|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ZNF703 DUSP6 SIGLEC10 ADGRE1

1.57e-04195624f398d08a23fdfa6202f73a7aeac3ff4c997fbdfd
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANK2 PTPRN SLIT1 NTNG1

1.57e-041956245a6a5048af638872700b76b7c71a8fa3fb8d3772
ToppCellmild-Myeloid-CD16_Monocytes|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ZNF703 DUSP6 SIGLEC10 ADGRE1

1.57e-04195624e963d33b50d43e38cada738e41343b64e3d08b79
ToppCellCOVID-19_Moderate-Non-classical_Monocyte|COVID-19_Moderate / disease group, cell group and cell class

ZNF703 DUSP6 SIGLEC10 ADGRE1

1.60e-04196624256c557fa11414c9d2cbb1fcff33f482ee1c78ac
ToppCellInfluenza_Severe-Non-classical_Monocyte|World / Disease group and Cell class

ZNF703 SIGLEC10 ADGRE1 NOTCH4

1.60e-041966248ef9810ee99082a9c803c7ecad6ceb5710d16b54
ToppCellmyeloid-CD16+_Monocyte|World / Lineage and Cell class

ZNF703 TKT SIGLEC10 ADGRE1

1.60e-04196624225c102e0a2047425a7125eba1d2359159c50409
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Nonclassical_Monocyte|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF703 DUSP6 SIGLEC10 ADGRE1

1.60e-0419662429246378ffb1010fe6858da756ae3d13df2306ba
ToppCellICU-NoSEP-Myeloid-CD16_Mono|ICU-NoSEP / Disease, Lineage and Cell Type

ZNF703 TKT SIGLEC10 ADGRE1

1.60e-04196624b15abb1c5396d038bab92b048795020199370f44
ToppCellBLOOD--(3)_Non_classical_monocytes| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

ZNF703 DUSP6 SIGLEC10 ADGRE1

1.60e-04196624b5ce99e27c9e87be52c10c022a665bf4df0e8b05
ToppCellnucseq-Mesenchymal-Fibroblastic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SLIT2 IL16 ANK2 NTNG1

1.60e-041966247d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell10x5'-Liver-Myeloid_Monocytic-Nonclassical_monocytes|Liver / Manually curated celltypes from each tissue

ZNF703 TKT SIGLEC10 ADGRE1

1.63e-04197624b0b4a704e1137f48e2258df17285ed89684ae98d
ToppCellmild_COVID-19-Non-classical_Monocyte|World / disease group, cell group and cell class (v2)

ZNF703 SIGLEC10 ADGRE1 NOTCH4

1.63e-04197624368644260f70895052a1d71171a9d882315354dd
DiseaseX-15666 measurement

PTPRN RESP18

4.07e-062602EFO_0800754
Diseasehemangioblastoma (is_marker_for)

DLL4 NOTCH4

2.43e-054602DOID:5241 (is_marker_for)
Diseasebipolar II disorder

SLIT1 ADGRE1

1.13e-048602EFO_0009964
DiseaseAcute Promyelocytic Leukemia

ASXL1 GLI1 WT1

1.14e-0446603C0023487
Diseasehemangiopericytoma (is_marker_for)

DLL4 NOTCH4

1.45e-049602DOID:264 (is_marker_for)
Diseasecystic kidney disease (implicated_via_orthology)

SLIT2 LAMA5

1.81e-0410602DOID:2975 (implicated_via_orthology)
Diseaseresponse to lithium ion

MEGF6 SLIT1 NOTCH4

2.05e-0456603GO_0010226
Diseasegallbladder cancer (is_implicated_in)

EGF GLI1

3.13e-0413602DOID:3121 (is_implicated_in)
DiseaseMyasthenic Syndromes, Congenital, Slow Channel

SCN4A LRP4

4.79e-0416602C0751885
DiseaseCongenital Myasthenic Syndromes, Postsynaptic

SCN4A LRP4

5.42e-0417602C0751883
DiseaseGlioblastoma

EGF DUSP6 WT1

5.66e-0479603C0017636
DiseaseGiant Cell Glioblastoma

EGF DUSP6 WT1

6.77e-0484603C0334588
DiseaseCongenital Myasthenic Syndromes, Presynaptic

SCN4A LRP4

6.80e-0419602C0751884
Diseasediffuse plaque measurement

ANK2 ADGRE1 KAT6B CSMD3 FBN3 NOTCH4 EVX2

8.50e-04758607EFO_0010699
DiseaseEpilepsy, Benign Psychomotor, Childhood

SLIT2 P2RX4

1.00e-0323602C0393672
DiseaseEpilepsy, Lateral Temporal

SLIT2 P2RX4

1.00e-0323602C0393682
DiseaseUncinate Epilepsy

SLIT2 P2RX4

1.00e-0323602C0014558
DiseaseEpilepsy, Temporal Lobe

SLIT2 P2RX4

1.00e-0323602C0014556
DiseaseMyasthenic Syndromes, Congenital

SCN4A LRP4

1.09e-0324602C0751882
DiseaseMalignant neoplasm of breast

EGF ANK2 DLL4 GLI1 WT1 CUBN KAT6B NOTCH4

1.43e-031074608C0006142
DiseaseGlioblastoma Multiforme

EGF DUSP6 WT1

1.52e-03111603C1621958
DiseaseMyeloid Leukemia, Chronic

ASXL1 WT1

1.59e-0329602C0023473
DiseaseBilateral Wilms Tumor

ASXL1 WT1

1.59e-0329602C2930471

Protein segments in the cluster

PeptideGeneStartEntry
PSCHAPCGSRSTGSE

CSMD3

1756

Q7Z407
ASNCRSSPSHTTNGC

C2orf69

216

Q8N8R5
SGGSAPCSCLSCHSS

EVX2

381

Q03828
HSTLSCADSPCFNGG

DLL4

361

Q9NR61
ISAHCNLCLPGSSDS

ASCC1

361

Q8N9N2
CDSHASCLNIPGSFS

FBN3

1291

Q75N90
EQTACHGPSGCLSNS

CCDC14

876

Q49A88
NCGAFGHTARSTTCP

FAM90A10

46

A6NDY2
SGCHADGESGSPSSS

ASXL1

191

Q8IXJ9
SSAGTPGAECLRSCH

MUC5B

806

Q9HC84
SHPCANGSTCTTVAN

NOTCH2NLA

111

Q7Z3S9
CKSDASCTAGSAGTH

P2RX4

126

Q99571
SCADCGSSGHPSCLK

KAT6B

236

Q8WYB5
ICDGHGCEAMSPSSS

ANK2

2771

Q01484
SPCASSGSGRACTLN

CACNA1F

281

O60840
SSRPGGCSAVSAHGC

PTPRN

26

Q16849
SSTHCSPESCGTASG

KRT40

6

Q6A162
GTASGCAPASSCSVE

KRT40

16

Q6A162
PHGCSSCDEGNAASS

TRIM71

196

Q2Q1W2
GLSPHCNGSDCGYSS

GGNBP2

456

Q9H3C7
GTAACPNGSFHCTNT

PRKCSH

66

P14314
SSDSSGSCPCDGARG

MESP2

36

Q0VG99
HAAPGLECSSGSANC

HPS4

501

Q9NQG7
SQGTSGFFCPSTHSC

PEAR1

221

Q5VY43
FSPTHCQIASGCLSG

DCAF10

536

Q5QP82
SSCSSGHTPPTCGQE

IL16

621

Q14005
SSCSSDHSPAGSAAN

GLI1

446

P08151
CISSHGAFGPNSAAC

LAMA5

1206

O15230
SHPCANGSTCTTVAN

NOTCH2NLC

111

P0DPK4
VCAPSFHSGSPACSS

DPRX

171

A6NFQ7
HADNPVGGDSCLCST

OTOP2

216

Q7RTS6
LCHSDVGGPCADSAS

GYG2

311

O15488
ELISCADCGNSGHPS

KAT6A

226

Q92794
SCPGGCSDTSAHDGQ

RESP18

66

Q5W5W9
DICSVSNGGCHPDAS

CUBN

351

O60494
SNGGCHPDASCSSTL

CUBN

356

O60494
HGSTFTCSCLAPFSG

HABP2

91

Q14520
HSCGENASCTNTEGG

EGF

921

P01133
GAGSHCPTSQSESNS

LTBP3

1181

Q9NS15
SMDGLGSSCPASHCR

HOXC13

56

P31276
QSSDCCSQPSGGSSC

LCE1E

91

Q5T753
CPGHSGVSCEEASSA

EMID1

96

Q96A84
HCETNLDGSCSSSSP

DUSP6

146

Q16828
CGNGLSSHFPCSESQ

NR1D2

301

Q14995
SSSCSCGGAPCHGVT

MEGF6

741

O75095
PSISSIGNCECFGHS

NTNG1

356

Q9Y2I2
DALLCGNSSDAGHCP

SCN4A

356

P35499
SSCSMACSLPSGAGN

TCP11X2

171

Q5H9J9
CHGDAQCSTNPLTGS

NOTCH4

401

Q99466
NSPSSTGSGNTEHSC

TLK2

181

Q86UE8
SCFCNPGFESSSGHL

ADGRE1

196

Q14246
GASSSSHCSGESQCR

AMMECR1

26

Q9Y4X0
HAAVTGASCCSPLSQ

LINC01561

91

Q8N1V8
SSGSPDSQHCASDGS

PLEKHG5

741

O94827
LGGSSCSTCSAHDPA

ZNF703

391

Q9H7S9
TAAGSGHPTSCCSAA

TKT

31

P29401
GCHTPTDSCTGSQAL

WT1

201

P19544
SDCGRSGHPSCLQFT

DPF2

296

Q92785
CAHGTCQPSSQAGFT

SLIT2

1341

O94813
GSHCSSECVASTPGD

PMS2CL

126

Q68D20
DSCSSGPCENGGTCH

SLIT1

966

O75093
EAEGLHCSCSSQASP

SIGLEC10

456

Q96LC7
SPANSSGDSAIASCH

ZBTB46

176

Q86UZ6
CPSGSHCQLTSDNSN

ZAN

2306

Q9Y493
AHGLASSPECACGRS

LRP4

16

O75096