Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	Rho-dependent protein serine/threonine kinase activity	ROCK2 ROCK1	6.95e-05	2	167	2	GO:0072518
GeneOntologyMolecularFunction	alpha-actinin binding	NPHS1 MAGI1 SYNPO2 PTPRT	1.24e-04	31	167	4	GO:0051393
GeneOntologyBiologicalProcess	regulation of angiotensin-activated signaling pathway	ROCK2 PRKCA ROCK1	2.11e-06	4	168	3	GO:0110061
Domain	IRF-3	IRF5 IRF6 IRF9	2.44e-05	7	168	3	PF10401
Domain	Mob1_phocein	MOB3A MOB3C MOB3B	2.44e-05	7	168	3	PF03637
Domain	IRF-3	IRF5 IRF6 IRF9	2.44e-05	7	168	3	SM01243
Domain	Interferon_reg_factor-3	IRF5 IRF6 IRF9	2.44e-05	7	168	3	IPR019471
Domain	MOB_kinase_act_fam	MOB3A MOB3C MOB3B	2.44e-05	7	168	3	IPR005301
Domain	-	MOB3A MOB3C MOB3B	2.44e-05	7	168	3	1.20.140.30
Domain	Mob1_phocein	MOB3A MOB3C MOB3B	2.44e-05	7	168	3	SM01388
Domain	IRF	IRF5 IRF6 IRF9	5.77e-05	9	168	3	SM00348
Domain	IRF	IRF5 IRF6 IRF9	5.77e-05	9	168	3	PF00605
Domain	Interferon_reg_fac_CS	IRF5 IRF6 IRF9	5.77e-05	9	168	3	IPR019817
Domain	Interferon_reg_fact_DNA-bd_dom	IRF5 IRF6 IRF9	5.77e-05	9	168	3	IPR001346
Domain	IRF_1	IRF5 IRF6 IRF9	5.77e-05	9	168	3	PS00601
Domain	IRF_2	IRF5 IRF6 IRF9	5.77e-05	9	168	3	PS51507
Domain	Rho_Binding	ROCK2 ROCK1	8.04e-05	2	168	2	PF08912
Domain	Rho-bd_dom	ROCK2 ROCK1	8.04e-05	2	168	2	IPR015008
Domain	ROCK1/ROCK2	ROCK2 ROCK1	8.04e-05	2	168	2	IPR020684
Domain	DENND6	DENND6A DENND6B	8.04e-05	2	168	2	IPR024224
Domain	REELIN	RELN FRRS1	2.40e-04	3	168	2	PS51019
Domain	Reeler_dom	RELN FRRS1	2.40e-04	3	168	2	IPR002861
Domain	Reeler	RELN FRRS1	2.40e-04	3	168	2	PF02014
Domain	Ferritin-like_SF	MOB3A MOB3C MOB3B	2.42e-04	14	168	3	IPR009078
Domain	SMAD_dom-like	IRF5 IRF6 IRF9	3.67e-04	16	168	3	IPR017855
Domain	-	IRF5 IRF6 IRF9	3.67e-04	16	168	3	2.60.200.10
Domain	SHR-BD	VPS13D VPS13B	4.77e-04	4	168	2	IPR009543
Domain	ABL9/DENND6_dom	DENND6A DENND6B	4.77e-04	4	168	2	IPR018307
Domain	Avl9	DENND6A DENND6B	4.77e-04	4	168	2	PF09794
Domain	VPS13_C	VPS13D VPS13B	4.77e-04	4	168	2	PF16909
Domain	VPS13_C	VPS13D VPS13B	4.77e-04	4	168	2	IPR031645
Domain	SHR-BD	VPS13D VPS13B	4.77e-04	4	168	2	PF06650
Domain	Myb-like_dom	EP400 TTF1	1.18e-03	6	168	2	IPR017877
Domain	SMAD_FHA_domain	IRF5 IRF6 IRF9 CEP170B	1.22e-03	52	168	4	IPR008984
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	ROCK2 ABI3BP SPEF2 GRK5 SIPA1L3 ASH1L NUP98 CC2D1B HMGCL KAT2A ARID1A C2CD3 PSIP1 FAM186A N4BP2 AVIL CES3 MAP7D2 AATF DLEC1 SKAP2 XRCC6 MYBPC1 UTP14C	1.84e-07	1442	171	24	35575683
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MON2 SH3RF1 EP400 GRK5 SIPA1L3 FBRS SLCO4A1 TMCO6 IRF5 KAT2A ARID1A BIRC6 RYR1 C2CD3 SUGP2 XPO6 MCM3AP ZFYVE26 HERC2 CEP170B	5.87e-07	1105	171	20	35748872
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	DIDO1 ZNF518A SUGP2 XPO6 PPIP5K1 ZFYVE26 HERC2	8.74e-07	104	171	7	9205841
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TPP2 NUP98 KRI1 DIDO1 RRP8 ARID1A TTF1 BIRC6 SUGP2 DDX18 MCM3AP AATF HERC2 XRCC6 KDM1A	9.28e-07	653	171	15	22586326
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ROCK2 SH3RF1 SIPA1L3 CC2D1B BIRC6 FARP2 VPS13D N4BP2 SCAPER EIF2AK1 CNOT3 UNC80 UTP14C	1.12e-06	493	171	13	15368895
Pubmed	The road to chromatin - nuclear entry of retroviruses.	NUP98 PSIP1 XRCC6	1.16e-06	5	171	3	17304248
Pubmed	Slit/Robo signaling modulates the proliferation of central nervous system progenitors.	ETV1 EOMES PRKCA HES1	4.64e-06	23	171	4	23083737
Pubmed	Tbr1 regulates differentiation of the preplate and layer 6.	RELN ETV1 EOMES NCAN	4.64e-06	23	171	4	11239428
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	PDXDC1 MPP1 ROCK2 MAGI1 SCYL3 UBXN6 APBB1 SLCO4A1 RGS12 FARP2 ROCK1 ZDHHC13 VPS13B	5.37e-06	569	171	13	30639242
Pubmed	Molecular characterization of human homologs of yeast MOB1.	MOB3A MOB3C MOB3B	6.42e-06	8	171	3	19739119
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	SLC25A21 ABI3BP TAGAP SPEF2 NUP98 KRI1 CSMD2 SIRT3 MOB3B	7.18e-06	265	171	9	19240061
Pubmed	Posttranslational modifications of HIV-1 integrase by various cellular proteins during viral replication.	KAT2A PSIP1 XRCC6	9.60e-06	9	171	3	23863879
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MON2 EP400 ZMYND8 ASH1L FBRS KAT2A ARID1A ZNF518A ACAD11 SUGP2 DDX18 MCM3AP SCAPER TAF4B ZDHHC13 CEP170B UNC80 KDM1A	1.08e-05	1116	171	18	31753913
Pubmed	Reelin sets the pace of neocortical neurogenesis.	RELN EOMES HES1	1.37e-05	10	171	3	22069190
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	MON2 COL10A1 DOCK11 RANBP3 ZMYND8 TMC4 BIRC6 FRRS1 NFE2 TAF4B	1.38e-05	363	171	10	14691545
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	CFAP47 FAT4 SGSM1 DOCK11 TNPO2 PCDHB12 CSMD2 BIRC6 RYR1 DENND6A PSIP1 MCM3AP ITPRIPL1 XRCC6	1.83e-05	736	171	14	29676528
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ROCK2 TPP2 MAGI1 DOCK11 SIPA1L3 HCN3 SH3KBP1 DIDO1 N4BP2 NCAN PRKCA ROCK1 HERC2 CEP170B XRCC6 KDM1A	2.39e-05	963	171	16	28671696
Pubmed	ROCK 1 and 2 affect the spatial architecture of 3D spheroids derived from human corneal stromal fibroblasts in different manners.	ROCK2 ROCK1	2.40e-05	2	171	2	35523828
Pubmed	Inhibition of Rho kinase protects against colitis in mice by attenuating intestinal epithelial barrier dysfunction via MLC and the NF-κB pathway.	ROCK2 ROCK1	2.40e-05	2	171	2	29115372
Pubmed	Investigation of the Rho-kinase Gene Polymorphism in Primary Open-angle Glaucoma.	ROCK2 ROCK1	2.40e-05	2	171	2	24617500
Pubmed	[Ouabain induces Rho-dependent rock activation and membrane blebbing incultured endothelial cells].	ROCK2 ROCK1	2.40e-05	2	171	2	25916120
Pubmed	Exome sequencing in four families with neurodevelopmental disorders: genotype-phenotype correlation and identification of novel disease-causing variants in VPS13B and RELN.	RELN VPS13B	2.40e-05	2	171	2	38771357
Pubmed	ROCK inhibitor Y-27632 inhibits the growth, migration, and invasion of Tca8113 and CAL-27 cells in tongue squamous cell carcinoma.	ROCK2 ROCK1	2.40e-05	2	171	2	26468018
Pubmed	ROCK1 and ROCK2 regulate epithelial polarisation and geometric cell shape.	ROCK2 ROCK1	2.40e-05	2	171	2	22462535
Pubmed	Distinct Roles For ROCK1 and ROCK2 in the Regulation of Oxldl-Mediated Endothelial Dysfunction.	ROCK2 ROCK1	2.40e-05	2	171	2	30165352
Pubmed	The Role of ROCK in Platelet-Monocyte Collaborative Induction of Thromboinflammation during Acute Coronary Syndrome.	ROCK2 ROCK1	2.40e-05	2	171	2	32877952
Pubmed	Toll-like receptor signaling in macrophages is regulated by extracellular substrate stiffness and Rho-associated coiled-coil kinase (ROCK1/2).	ROCK2 ROCK1	2.40e-05	2	171	2	29800294
Pubmed	Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts.	ROCK2 ROCK1	2.40e-05	2	171	2	18668558
Pubmed	ROCK1 and ROCK2 Are Down-regulated in Aggressive and Advanced Skin Melanomas - A Clinicopathological Perspective.	ROCK2 ROCK1	2.40e-05	2	171	2	32234882
Pubmed	Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice.	ROCK2 ROCK1	2.40e-05	2	171	2	15096457
Pubmed	ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression.	ROCK2 ROCK1	2.40e-05	2	171	2	22934846
Pubmed	Functional role of Rho-kinase in ameloblast differentiation.	ROCK2 ROCK1	2.40e-05	2	171	2	21792909
Pubmed	Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.	ROCK2 ROCK1	2.40e-05	2	171	2	20803696
Pubmed	Role of Rho Kinase and Fasudil on Synaptic Plasticity in Multiple Sclerosis.	ROCK2 ROCK1	2.40e-05	2	171	2	26481340
Pubmed	Inhibition of ROCK activity allows InlF-mediated invasion and increased virulence of Listeria monocytogenes.	ROCK2 ROCK1	2.40e-05	2	171	2	18331468
Pubmed	The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis.	ROCK2 ROCK1	2.40e-05	2	171	2	29211497
Pubmed	The connection between the cardiac glycoside-induced senescent cell morphology and Rho/Rho kinase pathway.	ROCK2 ROCK1	2.40e-05	2	171	2	30369081
Pubmed	Role of rho-kinase gene polymorphisms and protein expressions in colorectal cancer development.	ROCK2 ROCK1	2.40e-05	2	171	2	23328676
Pubmed	The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer.	ROCK2 ROCK1	2.40e-05	2	171	2	18695890
Pubmed	Opposing signaling of ROCK1 and ROCK2 determines the switching of substrate specificity and the mode of migration of glioblastoma cells.	ROCK2 ROCK1	2.40e-05	2	171	2	24170433
Pubmed	The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth.	USP21 MAP2K2	2.40e-05	2	171	2	29706623
Pubmed	Rho-associated kinases play an essential role in cardiac morphogenesis and cardiomyocyte proliferation.	ROCK2 ROCK1	2.40e-05	2	171	2	12508221
Pubmed	Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts.	ROCK2 ROCK1	2.40e-05	2	171	2	18695640
Pubmed	Remnant lipoproteins from patients with sudden cardiac death enhance coronary vasospastic activity through upregulation of Rho-kinase.	ROCK2 ROCK1	2.40e-05	2	171	2	15044207
Pubmed	Differential regulation of adhesion complex turnover by ROCK1 and ROCK2.	ROCK2 ROCK1	2.40e-05	2	171	2	22348083
Pubmed	Rho-associated kinase is a therapeutic target in neuroblastoma.	ROCK2 ROCK1	2.40e-05	2	171	2	28739902
Pubmed	Common variants of ROCKs and the risk of hypertension, and stroke: Two case-control studies and a follow-up study in Chinese Han population.	ROCK2 ROCK1	2.40e-05	2	171	2	29246448
Pubmed	Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction.	ROCK2 ROCK1	2.40e-05	2	171	2	28679962
Pubmed	Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation.	ROCK2 ROCK1	2.40e-05	2	171	2	17167780
Pubmed	Association of Rho-kinase Gene Polymorphisms with Respiratory Distress Syndrome in Preterm Neonates.	ROCK2 ROCK1	2.40e-05	2	171	2	27269648
Pubmed	Hyperoxia increases the elastic modulus of alveolar epithelial cells through Rho kinase.	ROCK2 ROCK1	2.40e-05	2	171	2	24289040
Pubmed	Rho kinase in the regulation of cell death and survival.	ROCK2 ROCK1	2.40e-05	2	171	2	17347801
Pubmed	Distinct distribution and localization of Rho-kinase in mouse epithelial, muscle and neural tissues.	ROCK2 ROCK1	2.40e-05	2	171	2	22986902
Pubmed	Activation of Rho kinase isoforms in lung endothelial cells during inflammation.	ROCK2 ROCK1	2.40e-05	2	171	2	19201893
Pubmed	Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation.	ROCK2 ROCK1	2.40e-05	2	171	2	19997641
Pubmed	Role of Rho kinase isoforms in murine allergic airway responses.	ROCK2 ROCK1	2.40e-05	2	171	2	21565918
Pubmed	ABI3BP promotes renal aging through Klotho-mediated ferroptosis.	ABI3BP KL	2.40e-05	2	171	2	38812032
Pubmed	Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation.	PRKCA HES1	2.40e-05	2	171	2	9389649
Pubmed	Podocytic PKC-alpha is regulated in murine and human diabetes and mediates nephrin endocytosis.	NPHS1 PRKCA	2.40e-05	2	171	2	20419132
Pubmed	ADAM10 as a major activator of reactive oxygen species production and klotho shedding in podocytes under diabetic conditions.	ADAM10 KL	2.40e-05	2	171	2	38815628
Pubmed	Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes.	FAT4 ARID1A	2.40e-05	2	171	2	22484628
Pubmed	The Rho kinase pathway regulates mouse adult neural precursor cell migration.	ROCK2 ROCK1	2.40e-05	2	171	2	21732490
Pubmed	ADAM-10-mediated N-cadherin cleavage is protein kinase C-alpha dependent and promotes glioblastoma cell migration.	ADAM10 PRKCA	2.40e-05	2	171	2	19357285
Pubmed	Comparative Study of ROCK1 and ROCK2 in Hippocampal Spine Formation and Synaptic Function.	ROCK2 ROCK1	2.40e-05	2	171	2	30826947
Pubmed	Adjustable passive stiffness in mouse bladder: regulated by Rho kinase and elevated following partial bladder outlet obstruction.	ROCK2 ROCK1	2.40e-05	2	171	2	22205227
Pubmed	SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70.	SIRT3 XRCC6	2.40e-05	2	171	2	18710944
Pubmed	Sulfide induces apoptosis and Rho kinase-dependent cell blebbing in Jurkat cells.	ROCK2 ROCK1	2.40e-05	2	171	2	23479079
Pubmed	Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension.	ROCK2 ROCK1	2.40e-05	2	171	2	19590140
Pubmed	Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo.	NPHS1 PRKCA	2.40e-05	2	171	2	16955103
Pubmed	Rho-GTPase effector ROCK phosphorylates cofilin in actin-meditated cytokinesis during mouse oocyte meiosis.	ROCK2 ROCK1	2.40e-05	2	171	2	24429217
Pubmed	Rocks: multifunctional kinases in cell behaviour.	ROCK2 ROCK1	2.40e-05	2	171	2	12778124
Pubmed	Rho kinases regulate corneal epithelial wound healing.	ROCK2 ROCK1	2.40e-05	2	171	2	18495812
Pubmed	t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia.	NUP98 PSIP1	2.40e-05	2	171	2	15725483
Pubmed	ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens.	ROCK2 ROCK1	2.40e-05	2	171	2	28035042
Pubmed	Distinct and complementary functions of rho kinase isoforms ROCK1 and ROCK2 in prefrontal cortex structural plasticity.	ROCK2 ROCK1	2.40e-05	2	171	2	30196430
Pubmed	Role of Rho-kinase in regulation of insulin action and glucose homeostasis.	ROCK2 ROCK1	2.40e-05	2	171	2	16098829
Pubmed	Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth.	ROCK2 ROCK1	2.40e-05	2	171	2	28709411
Pubmed	A Human Platelet Receptor Protein Microarray Identifies the High Affinity Immunoglobulin E Receptor Subunit α (FcεR1α) as an Activating Platelet Endothelium Aggregation Receptor 1 (PEAR1) Ligand.	FCER1A PEAR1	2.40e-05	2	171	2	25713122
Pubmed	Small molecule inhibition of cytoskeletal dynamics in melanoma tumors results in altered transcriptional expression patterns of key genes involved in tumor initiation and progression.	ROCK2 ROCK1	2.40e-05	2	171	2	21471517
Pubmed	Rho kinase inhibitors block melanoma cell migration and inhibit metastasis.	ROCK2 ROCK1	2.40e-05	2	171	2	25840982
Pubmed	Roles of PLC-gamma2 and PKCalpha in TPA-induced apoptosis of gastric cancer cells.	PRKCA PLCG2	2.40e-05	2	171	2	14606067
Pubmed	ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo.	ROCK2 ROCK1	2.40e-05	2	171	2	16098146
Pubmed	Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice.	ROCK2 ROCK1	2.40e-05	2	171	2	29987023
Pubmed	ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice.	ROCK2 ROCK1	2.40e-05	2	171	2	8772201
Pubmed	ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells.	ROCK2 ROCK1	2.40e-05	2	171	2	19131646
Pubmed	Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors.	ROCK2 ROCK1	2.40e-05	2	171	2	31302146
Pubmed	Rho kinases regulate the renewal and neural differentiation of embryonic stem cells in a cell plating density-dependent manner.	ROCK2 ROCK1	2.40e-05	2	171	2	20169147
Pubmed	SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.	ACO1 SIRT3	2.40e-05	2	171	2	24909164
Pubmed	ROCK2 Regulates Monocyte Migration and Cell to Cell Adhesion in Vascular Endothelial Cells.	ROCK2 ROCK1	2.40e-05	2	171	2	30884801
Pubmed	Rho-associated kinases play a role in endocardial cell differentiation and migration.	ROCK2 ROCK1	2.40e-05	2	171	2	15464581
Pubmed	Investigation of the esophageal Rho-kinase expression in patients with Barrett's esophagus.	ROCK2 ROCK1	2.40e-05	2	171	2	23789633
Pubmed	Role of Rho-Associated Coiled-Coil Forming Kinase Isoforms in Regulation of Stiffness-Induced Myofibroblast Differentiation in Lung Fibrosis.	ROCK2 ROCK1	2.40e-05	2	171	2	28225294
Pubmed	ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.	ROCK2 ROCK1	2.40e-05	2	171	2	18414683
Pubmed	ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in mice.	ROCK2 ROCK1	2.40e-05	2	171	2	31914704
Pubmed	ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness.	ROCK2 ROCK1	2.40e-05	2	171	2	30771534
Pubmed	Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2.	ROCK2 ROCK1	2.40e-05	2	171	2	26826790
Pubmed	ROCK inhibition prevents early mouse embryo development.	ROCK2 ROCK1	2.40e-05	2	171	2	24562870
Pubmed	Expression of the novel NUP98/PSIP1 fusion transcripts in myelodysplastic syndrome with t(9;11)(p22;p15).	NUP98 PSIP1	2.40e-05	2	171	2	22103895
Pubmed	Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both In Vitro and In Vivo.	ROCK2 ROCK1	2.40e-05	2	171	2	25934709
Pubmed	ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice.	ROCK2 ROCK1	2.40e-05	2	171	2	26276827
GeneFamily	MOB kinase activators\|STRIPAK complex	MOB3A MOB3C MOB3B	7.95e-06	7	112	3	647
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND5B DENND6A DENND6B	4.82e-04	25	112	3	504
GeneFamily	Fibronectin type III domain containing	NPHS1 ABI3BP PTPRT CNTN3 MYBPHL MYBPC1	4.83e-04	160	112	6	555
GeneFamily	Mitogen-activated protein kinase kinases	MAP2K2 MAP2K6	7.83e-04	7	112	2	653
GeneFamily	Fibronectin type III domain containing\|I-set domain containing\|Myosin binding proteins	MYBPHL MYBPC1	1.04e-03	8	112	2	658
GeneFamily	Fibrinogen C domain containing\|Angiopoietin like	ANGPTL1 ANGPTL4	1.04e-03	8	112	2	905
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	ASH1L KMT2E PRDM6	1.20e-03	34	112	3	487
GeneFamily	PHD finger proteins	ZMYND8 ASH1L DIDO1 KMT2E	2.37e-03	90	112	4	88
GeneFamily	PDZ domain containing	MPP1 MAGI1 SYNPO2 SIPA1L3 RGS12	2.56e-03	152	112	5	1220
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#5	PDXDC1 MPP1 FAT4 SYNPO2 ABI3BP ETV1 SLCO4A1 IL17RC KMT2E ANGPTL1 COL24A1 VPS13D ACAD11 ANGPTL4 SCAPER EXOC6B C1QA CNTN3 ECI2	5.46e-06	734	167	19	Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_2500_K5
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_1000	TPP2 FAT4 SYNPO2 PCDHB13 PCDHB12 ETV1 IRF6 TMC4 ADAM10 ANGPTL1 USP21 BNC1 C2CD3 CES3 CNTN3 HERC2 ASPRV1 ITPRIPL1 VPS13B	2.03e-05	806	167	19	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_1000
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#5	PDXDC1 MPP1 FAT4 SYNPO2 ABI3BP ETV1 SLCO4A1 IL17RC KMT2E ANGPTL1 COL24A1 ACAD11 ANGPTL4 SCAPER EXOC6B CNTN3 ECI2	6.15e-05	726	167	17	Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_2500_K5
CoexpressionAtlas	FacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_2500_k-means-cluster#4	PDXDC1 MPP1 FAT4 SYNPO2 ABI3BP ETV1 SLCO4A1 ANGPTL1 COL24A1 VPS13D ACAD11 ANGPTL4 SCAPER EXOC6B C1QA CNTN3 ECI2	6.69e-05	731	167	17	Facebase_RNAseq_e8.5_Paraxial Mesoderm_2500_K4
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 SH3RF1 SIPA1L3 RYR1 CIITA EXOC6B QPCT MYBPHL HPS5	1.89e-08	169	170	9	46f0f0de9a0894c454f93032e7a7a800f47c8276
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPHS1 TAGAP FCER1A CIITA CLIC2 QPCT MOB3B C1QA OCSTAMP	4.12e-08	185	170	9	7cf69717b88347833819c161ca89e751416f6c67
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_5\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLT3 CEBPD ASPHD2 CYP2S1 RYR1 FCER1A CIITA CLIC2 MOB3B	4.96e-08	189	170	9	807922b5ea0faddd3abfa9ec1b53f3f2b00e61bf
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_5\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3 CEBPD ASPHD2 CYP2S1 RYR1 FCER1A CIITA CLIC2 MOB3B	4.96e-08	189	170	9	c81b38cda4525254fe4fa137a4c9bc9abe0363bb
ToppCell	COPD-Myeloid-cDC2\|COPD / Disease state, Lineage and Cell class	FLT3 CEBPD SIPA1L3 CYP2S1 MOB3A FCER1A CIITA CLIC2 MOB3B	5.43e-08	191	170	9	2af6e4a6bd1f2193ece2131c3b7d976dd23a6966
ToppCell	PCW_13-14-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor3_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TAGAP IRF5 CYP2S1 NFAM1 RYR1 FCER1A CIITA C1QA PLCG2	6.48e-08	195	170	9	5f46f9aca1c7f76416e861aa94d24fc1d6266113
ToppCell	Sigmoid-Dendritic_cell\|Sigmoid / Region, Cell class and subclass	FLT3 CEBPD CYP2S1 RGS12 FCER1A CIITA CLIC2 MOB3B C1QA	8.05e-08	200	170	9	994a49317b806d115c630cd90897a91fc85ff467
ToppCell	Sigmoid-(5)_Dendritic_cell\|Sigmoid / shred on region, Cell_type, and subtype	FLT3 CEBPD CYP2S1 RGS12 FCER1A CIITA CLIC2 MOB3B C1QA	8.05e-08	200	170	9	1130328863a4fcfa7dcd7261e9905943057777c5
ToppCell	severe_influenza-cDC\|World / disease group, cell group and cell class (v2)	FLT3 SLCO4A1 CYP2S1 RGS12 FCER1A CIITA CLIC2 CES3	2.02e-07	161	170	8	802f8cafb5f499e3b2ec0193d6eb1ac9320b9287
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLT3 SH3RF1 RYR1 CIITA EXOC6B QPCT MYBPHL OCSTAMP	2.93e-07	169	170	8	9c9bb1b32fc6e22359424a262178906c3954415d
ToppCell	10x5'-bone_marrow-Myeloid_Dendritic-DC2\|bone_marrow / Manually curated celltypes from each tissue	FLT3 CEBPD IRF5 CYP2S1 FCER1A CIITA CLIC2 C1QA	3.35e-07	172	170	8	64928cea7e5b60e4bc4af016454b0173ebcc07c7
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_8\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLT3 CEBPD CYP2S1 RYR1 FCER1A CIITA CLIC2 HES1	6.58e-07	188	170	8	d8f10b3ad11bc99a63f44560e39791085256e5c8
ToppCell	COPD-Myeloid-cDC2\|World / Disease state, Lineage and Cell class	FLT3 CEBPD SIPA1L3 CYP2S1 MOB3A FCER1A CIITA CLIC2	7.42e-07	191	170	8	4e4887175200a57e1b041f2f131e3df774df3509
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_5\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLT3 ASPHD2 CYP2S1 RYR1 FCER1A CIITA CLIC2 MOB3B	7.42e-07	191	170	8	92c5a26b90a55831039220341d863cf2940f3c9b
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_5\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3 ASPHD2 CYP2S1 RYR1 FCER1A CIITA CLIC2 MOB3B	7.71e-07	192	170	8	6184163dbfca882824cb266bb9030d9f79e3acb0
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	DENND5B MAGI1 SH3RF1 ASH1L SCAPER EXOC6B PRKCA VPS13B	7.71e-07	192	170	8	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	COVID-19_Severe-cDC\|COVID-19_Severe / disease group, cell group and cell class	FLT3 CEBPD ASPHD2 CYP2S1 RYR1 FCER1A CIITA CLIC2	8.67e-07	195	170	8	6419090b19de7b5d5140eaecf231860273da2c0d
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	ARID1A CSMD2 FREM3 ZNF804A ZNF518A VPS13D CNTN3	8.96e-07	135	170	7	3351e8b9e417397c5fa9f856184ff24ce1a27242
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Dendritic_cell-DC_1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NPHS1 FLT3 CYP2S1 FCER1A CIITA TMEM132E C1QA HPS5	9.36e-07	197	170	8	81dd7f9318f0ba175352e5156c24772427e0b34f
ToppCell	Healthy_donor-cDC\|World / disease group, cell group and cell class (v2)	FLT3 ASPHD2 CYP2S1 RYR1 FCER1A CIITA CLIC2 MOB3B	9.36e-07	197	170	8	a545fe3a80cd721bf01115bbb645753840ec9f40
ToppCell	COVID-19_Severe-cDC\|World / disease group, cell group and cell class	FLT3 CEBPD ASPHD2 CYP2S1 RYR1 FCER1A CIITA CLIC2	9.72e-07	198	170	8	c452334249f047265ae89dcabe7de446d968cae6
ToppCell	control-cDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FLT3 IRF5 ASPHD2 CYP2S1 RYR1 FCER1A CIITA CLIC2	1.01e-06	199	170	8	31825ba336603fe940dea6022e18ec25af110f4c
ToppCell	Sigmoid-(5)_Dendritic_cell-(50)_cDC2\|Sigmoid / shred on region, Cell_type, and subtype	FLT3 CEBPD CYP2S1 RGS12 FCER1A CIITA CLIC2 MOB3B	1.01e-06	199	170	8	402af84db90d8a49d67cf44c24766aefb00fd716
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NPHS1 FLT3 CYP2S1 FCER1A CIITA TMEM132E QPCT C1QA	1.01e-06	199	170	8	d330e28075096a09da3c27db8b52e364967c1e34
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FLT3 CYP2S1 CIITA CLIC2 TMEM132E QPCT HPS5 MAP2K6	1.01e-06	199	170	8	26ea06960e8ea061a71756750b84489609f78162
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	MON2 MAGI1 SIPA1L3 BIRC6 SCAPER EXOC6B PRKCA VPS13B	1.01e-06	199	170	8	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Sigmoid-Dendritic_cell-cDC2\|Sigmoid / Region, Cell class and subclass	FLT3 CEBPD CYP2S1 RGS12 FCER1A CIITA CLIC2 MOB3B	1.01e-06	199	170	8	cd74db6db694b68f81dcf9d9342d125d00357ec1
ToppCell	(50)_cDC2\|World / shred on Cell_type and subtype	FLT3 CEBPD CYP2S1 RGS12 FCER1A CIITA CLIC2 C1QA	1.31e-06	206	170	8	d519adeb8290fcce107e81a439ba3bf1e231b55b
ToppCell	Tracheal-10x5prime-Hematologic-Erythrocyte-Erythrocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MPP1 FLT3 CGA ZNF804A NFE2 EIF2AK1	1.86e-06	96	170	6	c3ac1626a3f3931784605f95db1fcdec2c8ad62e
ToppCell	Tracheal-10x5prime-Hematologic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MPP1 FLT3 CGA ZNF804A NFE2 EIF2AK1	1.86e-06	96	170	6	5bd480030df9a4cb8c3b4b6ceee20981fbd67baf
ToppCell	Tracheal-10x5prime-Hematologic-Erythrocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MPP1 FLT3 CGA ZNF804A NFE2 EIF2AK1	1.86e-06	96	170	6	74521ab61413f17a9858d3ea4ea63999459aafbc
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	TAGAP MOB3A ANGPTL1 FARP2 CIITA PLCG2 ZDHHC13	3.15e-06	163	170	7	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	Influenza_Severe-cDC\|Influenza_Severe / Disease group and Cell class	CYP2S1 RGS12 FRRS1 FCER1A CES3 MOB3B TAF4B	3.56e-06	166	170	7	b40bdf0f7f381e25be61188e9f6c294d25a8b824
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK11 ARL11 IRF5 NFAM1 FRRS1 NFE2 PLCG2	3.56e-06	166	170	7	82fa07632f7e586698fbf37381715b40f9f6ae3a
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK11 ARL11 IRF5 NFAM1 FRRS1 NFE2 PLCG2	3.56e-06	166	170	7	0d03926452414f232c77fd15d5f48d148f9fca3b
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RYR1 HSF5 CIITA NFE2 AVIL CES3 MOB3B	3.85e-06	168	170	7	d60f7cd8269f373827f49c7785002cb38e4570a9
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RYR1 HSF5 CIITA NFE2 AVIL CES3 MOB3B	4.00e-06	169	170	7	ccd98f9005aa0a88bd49f153be4e7200cc3dd0ac
ToppCell	facs-GAT-Fat-18m-Myeloid-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 IRF5 NFAM1 RYR1 CIITA PLCG2 SKAP2	4.00e-06	169	170	7	7a7416fcbffcf57d19b477d9da091e04e3499524
ToppCell	facs-GAT-Fat-18m-Myeloid\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 IRF5 NFAM1 RYR1 CIITA PLCG2 SKAP2	4.00e-06	169	170	7	0e1a99cd77edcf32bcb513abd247b2b27409ac63
ToppCell	facs-GAT-Fat-18m-Myeloid-myeloid_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 IRF5 NFAM1 RYR1 CIITA PLCG2 SKAP2	4.00e-06	169	170	7	9bbad31ef03078f5aa456f2e1b17b49c91545ff0
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage\|390C / Donor, Lineage, Cell class and subclass (all cells)	MPP1 FLT3 ZNF804A CIITA QPCT MOB3B ZFYVE26	4.16e-06	170	170	7	3a7121d045f9ae54583b0f5f7436abf3665a1bce
ToppCell	10x5'-blood-Myeloid_Dendritic-pDC\|blood / Manually curated celltypes from each tissue	DENND5B COL24A1 FCER1A CIITA CLIC2 N4BP2 MAP7D2	4.16e-06	170	170	7	59cb1262ff319349d42b11afbec2a9035b7b79f2
ToppCell	mild_COVID-19_(asymptomatic)-cDC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	NPHS1 FLT3 RYR1 FCER1A CIITA CLIC2 MOB3B	4.67e-06	173	170	7	71dc0051c87b84e3cf13cde8858166f2a474b5dc
ToppCell	droplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLT3 IRF5 RYR1 CIITA QPCT ZDHHC13 OCSTAMP	5.04e-06	175	170	7	4655d3daa95e8ffa7d5ee4180de06b2fec361bfb
ToppCell	PND07-28-samps-Myeloid-Macrophage-macrophage_-_intermediate_-_unactivated\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PCDHB12 FBRS SLCO4A1 FCER1A NFE2 DENND6B	5.07e-06	114	170	6	1c99483a492d08b6bb745006fe24c22841dc57ad
ToppCell	droplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLT3 IRF5 NFAM1 RYR1 CIITA PLCG2 OCSTAMP	5.23e-06	176	170	7	7b5e50eb144bf43ca0cf354a466eb58b976a79f1
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-hematologic-erythrocytic\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MPP1 RELN SLC25A21 GRHL1 CLIC2 NFE2 EIF2AK1	5.84e-06	179	170	7	64672528f73ac0921f9c7df72e14ecbfac4d5270
ToppCell	IIH-matDC-\|IIH / Condition, Cell_class and T cell subcluster	SYNPO2 ABI3BP ANGPTL1 HES1 PAX1 PRDM6 PEAR1	5.84e-06	179	170	7	46074b2781ed79e2979428b3ec81504621d3903c
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MPP1 RELN SLC25A21 GRHL1 CLIC2 NFE2 EIF2AK1	5.84e-06	179	170	7	dfefa4b7ae0ee50cf67e0f1938c682f08a03ec53
ToppCell	IIH-matDC\|IIH / Condition, Cell_class and T cell subcluster	SYNPO2 ABI3BP ANGPTL1 HES1 PAX1 PRDM6 PEAR1	5.84e-06	179	170	7	5999c85ce3bab5309ff1ed154be7e32b037750b1
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-hematologic\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MPP1 RELN SLC25A21 GRHL1 CLIC2 NFE2 EIF2AK1	5.84e-06	179	170	7	fa0dd87111d399649cdea55f2e610ebc169e8a56
ToppCell	mild_COVID-19_(asymptomatic)-cDC\|World / disease group, cell group and cell class (v2)	CYP2S1 RGS12 RYR1 FCER1A CIITA CLIC2 MOB3B	6.06e-06	180	170	7	68d1c867734fb2977b01ac686b20bf602f9a6b72
ToppCell	11.5-Distal-Immune-Immune\|Distal / Age, Tissue, Lineage and Cell class	FLT3 TAGAP ARL11 IRF5 ZNF804A FCER1A CIITA	6.28e-06	181	170	7	193ee02f547a218b2fc13e1174ea4cff4f8a3450
ToppCell	facs-Aorta-Heart-3m-Myeloid-macrophage\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 IRF5 MOB3A NFAM1 RYR1 CIITA PLCG2	6.51e-06	182	170	7	df26388c0c46d1c4775103c8e802937b4d4e7470
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic-DC2\|bone_marrow / Manually curated celltypes from each tissue	FLT3 CEBPD CYP2S1 FCER1A CIITA CLIC2 MOB3B	6.75e-06	183	170	7	f482e4fe011fa450a475034b1e25587233855bdb
ToppCell	facs-Aorta-Heart-3m-Myeloid-leukocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 ARL11 IRF5 MOB3A NFAM1 CIITA PLCG2	6.75e-06	183	170	7	062ec08d66c923f90fee771b1bf8d98bdc7e6c1b
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 ABI3BP SLCO4A1 CYP2S1 ITIH3 SFXN5 MYBPC1	7.00e-06	184	170	7	6b0c110d8930df99043c3b99cf4d873985126960
ToppCell	tumor_Lung-Myeloid_cells-CD141+_DCs\|tumor_Lung / Location, Cell class and cell subclass	FLT3 CYP2S1 CLIC2 TMEM132E QPCT HPS5 MAP2K6	7.00e-06	184	170	7	f5cad8eb358898ae536cd7a7b37d3ce19528b801
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 ABI3BP SLCO4A1 CYP2S1 ITIH3 SFXN5 MYBPC1	7.00e-06	184	170	7	35928fc5f7bbf8c7b09181a2bd27e22dff42ec16
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_8\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3 CYP2S1 RYR1 FCER1A CIITA CLIC2 HES1	8.05e-06	188	170	7	8431991e68b8e9c5eb72212460f6da679ea3b85a
ToppCell	IPF-Myeloid-cDC1\|IPF / Disease state, Lineage and Cell class	FLT3 SIPA1L3 CYP2S1 FARP2 CIITA CLIC2 HPS5	8.05e-06	188	170	7	2331a2bae1383820d598e93aa86c75b101069bac
ToppCell	CTRL-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	DENND5B SIPA1L3 MOB3A CIITA MOB3B PLCG2 SKAP2	8.33e-06	189	170	7	14f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3 CYP2S1 RYR1 FCER1A CIITA CLIC2 HES1	8.93e-06	191	170	7	6cda82a994f4b205cf54590c979d7c9f3be2b4c8
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLT3 CYP2S1 RYR1 FCER1A CIITA CLIC2 HES1	8.93e-06	191	170	7	4257f02856f3510981e9f84d465d91448d6126e2
ToppCell	COPD-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	FLT3 CEBPD SIPA1L3 CYP2S1 FCER1A CIITA CLIC2	9.23e-06	192	170	7	984cdc2f1d93e164bc946d63f58dacb629f82eb7
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLT3 ASPHD2 CYP2S1 FCER1A CIITA CLIC2 MOB3B	9.23e-06	192	170	7	dfb9101622f7d2f2c392e850cff07becfc8c655e
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3 ASPHD2 CYP2S1 FCER1A CIITA CLIC2 MOB3B	9.23e-06	192	170	7	d39133cf1a20af6f2970188630fc3b27a4cfc9c5
ToppCell	URO\|World / Disease, Lineage and Cell Type	VMP1 CEBPD SLCO4A1 NFAM1 NFE2 VNN2 C1QA	9.55e-06	193	170	7	421dc0996c6c973f88e90197b651255ae4dd13a2
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLT3 CYP2S1 RYR1 FCER1A CIITA CLIC2 HPS5	9.88e-06	194	170	7	2210f0755882d8f04edb4c109fb17c3f9149f6f7
ToppCell	IPF-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	FLT3 CEBPD SIPA1L3 CYP2S1 FCER1A CIITA CLIC2	9.88e-06	194	170	7	accf4b7b09e2048f2e47a52201e0158684dda8fe
ToppCell	367C-Myeloid-Dendritic-cDC2\|367C / Donor, Lineage, Cell class and subclass (all cells)	FLT3 CEBPD CYP2S1 FCER1A CIITA CLIC2 MOB3B	9.88e-06	194	170	7	d0ffba657c7308feecaa62dd54c920d32be0f129
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3 CYP2S1 RYR1 FCER1A CIITA CLIC2 HPS5	9.88e-06	194	170	7	b16ed97eb6b7b7a220e943474c0d85c141b6e3a5
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT4 SYNPO2 COL10A1 ANGPTL1 COL24A1 C1R PRDM6	9.88e-06	194	170	7	8fae8061b350336299aa81f378e07deadbd55123
ToppCell	control-Lymphocytic-CD4_T_cells_2\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	VMP1 CEBPD NFAM1 NFE2 VNN2 XPO6 QPCT	9.88e-06	194	170	7	c2ae2ea848d78725455dcb6be9f1d8933745fa80
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT4 SYNPO2 COL10A1 ANGPTL1 COL24A1 C1R PRDM6	9.88e-06	194	170	7	4d7d24390fdb379f943ddcc70a63f23955e10163
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_dendritic_(11)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TAGAP IRF5 CYP2S1 NFAM1 FCER1A CIITA C1QA	1.02e-05	195	170	7	4387e27d2288fb46a9ed110464542a4aea402358
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor3_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TAGAP ARL11 CYP2S1 RYR1 FCER1A CIITA C1QA	1.02e-05	195	170	7	c707885d092aedbbe14f51f7de4a5911c9214289
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4\|TCGA-Prostate / Sample_Type by Project: Shred V9	GRK5 CYP2S1 MOB3C MOB3B C1R PLCG2 ITPRIPL1	1.02e-05	195	170	7	5562665dd3beb70e2358aa32611a337bef5731c1
ToppCell	PBMC-Control-Myeloid-cDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FLT3 CEBPD CYP2S1 RYR1 FCER1A CIITA CLIC2	1.06e-05	196	170	7	e1f763fa9c11bf5f4d80e79f70f9485724ac23fe
ToppCell	PBMC-Control-Myeloid-cDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3 CEBPD CYP2S1 RYR1 FCER1A CIITA CLIC2	1.06e-05	196	170	7	d376168e15ec1cf618723259966c76be3698b9b0
ToppCell	Control-Myeloid-cDC\|Control / Disease group, lineage and cell class	FLT3 CEBPD CYP2S1 RYR1 FCER1A CIITA CLIC2	1.06e-05	196	170	7	85d92bc226cc28384c30991cc4ebb02ec2e3ec99
ToppCell	PBMC-Control-Myeloid-cDC-cDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3 CEBPD CYP2S1 RYR1 FCER1A CIITA CLIC2	1.06e-05	196	170	7	553c22c7d48f3b4f6f2b2f10d6e668c5ebb09e8c
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_cell-B_naive\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND5B ZNF804A ANGPTL1 HSF5 OR6A2 CIITA PLCG2	1.06e-05	196	170	7	de43dd0697e1daf4d50800957cf0b27b54a7a333
ToppCell	PBMC-Control-Myeloid-cDC-cDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FLT3 CEBPD CYP2S1 RYR1 FCER1A CIITA CLIC2	1.06e-05	196	170	7	4a9095ba3f6709f88f32bf09184553f4bd211f43
ToppCell	Healthy_donor-cDC\|Healthy_donor / disease group, cell group and cell class (v2)	FLT3 CYP2S1 RYR1 FCER1A CIITA CLIC2 MOB3B	1.09e-05	197	170	7	b57a27e5b855bbdd1dfa352540599d260dc482aa
ToppCell	mild_COVID-19-cDC\|World / disease group, cell group and cell class (v2)	FLT3 CYP2S1 RYR1 FCER1A CIITA CLIC2 MOB3B	1.09e-05	197	170	7	63e7b040c64f1e28b8db79980c7b580caa7d1b95
ToppCell	Monocytes-cDCs\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	DENND5B FLT3 CYP2S1 FCER1A CIITA CLIC2 MAP2K6	1.09e-05	197	170	7	15cb9fe1c3bab80bd24728fd9ac7ba385912ac33
ToppCell	10x_3'_v3-blood_(10x_3'_v3)\|10x_3'_v3 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MPP1 FLT3 CEBPD NFAM1 NFE2 VNN2 QPCT	1.09e-05	197	170	7	2d3547107c88c7443fc6425742694e13368a71f5
ToppCell	mild_COVID-19-cDC\|mild_COVID-19 / disease group, cell group and cell class (v2)	FLT3 CYP2S1 RYR1 FCER1A CIITA CLIC2 MOB3B	1.09e-05	197	170	7	44ebd3f967779bb7753fc6dcd9fde6d682f9ccd6
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT4 SYNPO2 ABI3BP GRK5 CSMD2 C1R PRDM6	1.09e-05	197	170	7	0dd71e399f253787fa546a7e90c5373180b89ffd
ToppCell	Healthy/Control-cDC\|World / Disease group and Cell class	FLT3 CYP2S1 RYR1 FCER1A CIITA CLIC2 MOB3B	1.09e-05	197	170	7	4497d4073f4d3e74de907325fba9eb4af5766bf4
ToppCell	Healthy-cDC\|World / disease group, cell group and cell class	FLT3 CEBPD CYP2S1 RYR1 FCER1A CIITA CLIC2	1.13e-05	198	170	7	8976f8d26cb7ff79f74def138c4bbbb0bc2eaf00
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FLT3 TAGAP NFAM1 ZNF804A FCER1A CIITA C1QA	1.13e-05	198	170	7	d73585a5587941483db8d9ddc2d68f7d852bbbc8
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	MAGI1 SH3RF1 SIPA1L3 SCAPER EXOC6B PRKCA VPS13B	1.13e-05	198	170	7	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC1\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLT3 SYNPO2 CYP2S1 CIITA CLIC2 QPCT HPS5	1.17e-05	199	170	7	c6da5c517dbcfa621fa6dda9e0c1985ba2f3bbdb
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC1-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLT3 SYNPO2 CYP2S1 CIITA CLIC2 QPCT HPS5	1.17e-05	199	170	7	b9613e88c4b752529d6ae20857744418207b0830
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Dendritic_cell-DC_2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FLT3 TAGAP CYP2S1 FCER1A CIITA MOB3B C1QA	1.17e-05	199	170	7	fdd8c4c04837341e17a4772a2adcdf2f187c56b1
ToppCell	Control-Control-Myeloid-cDC\|Control / Disease, condition lineage and cell class	FLT3 CEBPD CYP2S1 RYR1 FCER1A CIITA CLIC2	1.20e-05	200	170	7	1375d199320feb85ba06e74b10df6521e790addf
ToppCell	cellseq-Mesenchymal-Myocytic-Myocytic_2-SCMF\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SYNPO2 COL10A1 ABI3BP ANGPTL1 COL24A1 C1R PRDM6	1.20e-05	200	170	7	b441b3771fb7d9ee7b7a104afc35e466aace2da2
ToppCell	severe-cDC\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FLT3 SH3RF1 CYP2S1 FCER1A CIITA CLIC2 MOB3B	1.20e-05	200	170	7	26e04ea276dbca5cde48335c401269c7123b54d2
Drug	Trimethadione [127-48-0]; Down 200; 28uM; MCF7; HT_HG-U133A	TNPO2 RANBP3 SIPA1L3 UBXN6 SIRT3 VPS13D FBXO22 SUGP2 SCAPER CEP170B	2.51e-06	198	170	10	2846_DN
Drug	Pirlindole mesylate [60762-57-4]; Down 200; 12.4uM; MCF7; HT_HG-U133A	TPP2 MAGI1 RANBP3 GRK5 ZMYND8 FBRS IRF5 RGS12 VPS13D SCAPER	2.62e-06	199	170	10	5497_DN
Drug	Azathymine, 6 [932-53-6]; Down 200; 31.4uM; MCF7; HT_HG-U133A	ABI3BP GRK5 ZMYND8 UBXN6 IRF5 SUGP2 MCM3AP CES3 QPCT	1.66e-05	195	170	9	4106_DN
Drug	Tetracycline hydrochloride [64-75-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A	FLT3 FKRP GRK5 TMCO6 IRF6 RYR1 SCAPER MOB3B TRDMT1	1.73e-05	196	170	9	2243_UP
Drug	Decamethonium bromide [541-22-0]; Down 200; 9.6uM; MCF7; HT_HG-U133A	ROCK2 RANBP3 SIPA1L3 IRF6 RGS12 SIRT3 SEC24D MAP2K6 CNOT3	1.73e-05	196	170	9	7353_DN
Drug	Perhexiline maleate [6724-53-4]; Down 200; 10.2uM; PC3; HT_HG-U133A	FAT4 SCYL3 ASH1L ETV1 TMCO6 ARID1A IRF9 SCAPER EIF2AK1	1.73e-05	196	170	9	5081_DN
Drug	Sulfasalazine [599-79-1]; Down 200; 10uM; MCF7; HT_HG-U133A	SLC25A21 GRK5 CGA UBXN6 TMCO6 RGS12 SPRYD7 SCAPER TAF4B	1.73e-05	196	170	9	5446_DN
Drug	raloxifene hydrochloride; Up 200; 0.1uM; HL60; HG-U133A	FBRS SIRT3 PTPRT AVIL MOB3B C1QA PRKCA PAX1 VPS13B	1.80e-05	197	170	9	388_UP
Drug	Dubinidine [22964-77-8]; Up 200; 14.6uM; HL60; HT_HG-U133A	DENND5B ETV1 IL17RC SIRT3 CIITA SLCO1A2 CES3 HES1 CNOT3	1.80e-05	197	170	9	6131_UP
Drug	Mifepristone [84371-65-3]; Up 200; 9.4uM; PC3; HT_HG-U133A	MON2 SIPA1L3 FBRS CHI3L2 RGS12 SPRYD7 SEC24D VNN2 ANGPTL4	1.87e-05	198	170	9	5827_UP
Drug	Bufexamac [2438-72-4]; Down 200; 18uM; MCF7; HT_HG-U133A	ROCK2 SLC25A21 RANBP3 DIDO1 IRF5 VPS13D ROCK1 HES1 EIF2AK1	1.87e-05	198	170	9	5515_DN
Drug	(+,-)-Octopamine hydrochloride [770-05-8]; Down 200; 21uM; MCF7; HT_HG-U133A	RANBP3 FBRS IRF5 IRF6 KAT2A USP21 QPCT ROCK1 SKAP2	1.87e-05	198	170	9	5469_DN
Drug	CGX 0596987; Down 200; 20uM; MCF7; HT_HG-U133A	MON2 ROCK2 COL10A1 RRP8 ARID1A STMN4 CIITA PAX1 VPS13B	1.95e-05	199	170	9	6364_DN
Drug	Pargyline hydrochloride [306-07-0]; Up 200; 20.4uM; MCF7; HT_HG-U133A	RANBP3 ASH1L IL17RC KAT2A IRF9 VPS13D SCAPER TAF4B MAP2K6	1.95e-05	199	170	9	7016_UP
Drug	Galanthamine hydrobromide [1953-04-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A	CGA UBXN6 IL17RC RGS12 SIRT3 SEC24D VNN2 SCAPER PRKCA	1.95e-05	199	170	9	2787_UP
Drug	Terazosin hydrochloride [63590-64-7]; Down 200; 9.4uM; PC3; HT_HG-U133A	TPP2 SIPA1L3 SCYL3 FBRS IRF5 IL17RC TTF1 VPS13D SCAPER	2.03e-05	200	170	9	5831_DN
Drug	GGTI-297	ROCK2 PRKCA ROCK1	2.23e-05	8	170	3	CID009956145
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	CEBPD TNPO2 ZMYND8 FBRS DIDO1 ARID1A ZNF804A CNOT3	4.30e-05	170	170	8	3791_DN
Drug	Rockout	ROCK2 ROCK1	5.54e-05	2	170	2	CID000644354
Drug	3,3-dimethylacryloyl chloride	ROCK2 ROCK1	5.54e-05	2	170	2	CID000102394
Drug	17beta-estradiol glucuronide	SLCO4A1 SLC10A1 SLC22A8 SLCO1A2	9.16e-05	32	170	4	CID000066424
Drug	Lasalocid sodium salt [25999-20-6]; Down 200; 6.6uM; PC3; HT_HG-U133A	SLC25A21 SIPA1L3 ZMYND8 ETV1 SIRT3 FBXO22 CES3 HES1	1.01e-04	192	170	8	6639_DN
Drug	NS-398; Down 200; 10uM; PC3; HT_HG-U133A	FKRP RANBP3 SIPA1L3 IL17RC USP21 VPS13D FBXO22 EXOC6B	1.13e-04	195	170	8	6892_DN
Drug	Hesperetin [520-33-2]; Up 200; 13.2uM; MCF7; HT_HG-U133A	RANBP3 SIPA1L3 UBXN6 IRF5 IRF6 ARID1A RGS12 CES3	1.17e-04	196	170	8	5350_UP
Drug	Acyclovir [59277-89-3]; Down 200; 17.8uM; HL60; HG-U133A	ROCK2 RANBP3 GRK5 UBXN6 DIDO1 VPS13D CAPN7 PRKCA	1.17e-04	196	170	8	2044_DN
Drug	Trimethobenzamide hydrochloride [554-92-7]; Down 200; 9.4uM; PC3; HT_HG-U133A	CGA ZMYND8 ASH1L IL17RC STMN4 VPS13D SUGP2 MCM3AP	1.17e-04	196	170	8	4100_DN
Drug	Pancuronium bromide [15500-66-0]; Down 200; 5.4uM; MCF7; HT_HG-U133A	RANBP3 ZMYND8 ASH1L FBRS TMCO6 IRF6 ADAM10 ZDHHC13	1.17e-04	196	170	8	7329_DN
Drug	Trimethoprim [738-70-5]; Up 200; 13.8uM; PC3; HT_HG-U133A	SLC25A21 COL10A1 GRK5 ETV1 MAU2 CHI3L2 SEC24D AVIL	1.17e-04	196	170	8	3678_UP
Drug	Tetracaone hydrochloride [136-47-0]; Down 200; 13.2uM; MCF7; HT_HG-U133A	ABI3BP TNPO2 RGS12 RYR1 VPS13D EXOC6B PRKCA VPS13B	1.17e-04	196	170	8	2888_DN
Drug	Kynurenine, 3-hydroxy (R,S) [2147-61-7]; Down 200; 17.8uM; HL60; HT_HG-U133A	RANBP3 TMCO6 KAT2A SIRT3 SEC24D ECI2 MAP2K6 CEP170B	1.17e-04	196	170	8	1300_DN
Drug	4-O-methyl-TPA	SLC25A21 SLC22A8 PRKCA ASPRV1	1.17e-04	34	170	4	CID000072292
Drug	Scopolamin-N-oxide hydrobromide [6106-81-6]; Down 200; 10uM; MCF7; HT_HG-U133A	ABI3BP RANBP3 SIPA1L3 CGA VPS13D SCAPER CES3 VPS13B	1.21e-04	197	170	8	5436_DN
Drug	Vinpocetine [42971-09-5]; Down 200; 11.4uM; MCF7; HT_HG-U133A	RANBP3 UBXN6 MCM3AP SCAPER EXOC6B EIF2AK1 SKAP2 VPS13B	1.21e-04	197	170	8	3174_DN
Drug	Isoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Up 200; 16.4uM; PC3; HT_HG-U133A	MAGI1 SLC25A21 ETV1 TMCO6 ARID1A BNC1 SLC10A1 CIITA	1.21e-04	197	170	8	4226_UP
Drug	Bephenium hydroxynaphthoate [3818-50-6]; Up 200; 9uM; PC3; HT_HG-U133A	MAGI1 APBB1 ETV1 IRF5 MAU2 RGS12 PRKCA TAF4B	1.21e-04	197	170	8	4668_UP
Drug	ICI182,780; Down 200; 1uM; PC3; HT_HG-U133A	ROCK2 SIPA1L3 ZMYND8 ETV1 ADAM10 VPS13D FBXO22 SCAPER	1.21e-04	197	170	8	6867_DN
Drug	(cis-) Nanophine [5072-45-7]; Down 200; 26.8uM; MCF7; HT_HG-U133A	FKRP RANBP3 GRK5 RGS12 VPS13D SCAPER CES3 TRDMT1	1.21e-04	197	170	8	4363_DN
Drug	Amikacin hydrate [37517-28-5]; Up 200; 6.6uM; MCF7; HT_HG-U133A	GRK5 CGA IL17RC ZNF804A RGS12 SIRT3 SCAPER CES3	1.21e-04	197	170	8	5314_UP
Drug	5211181; Down 200; 12uM; MCF7; HT_HG-U133A_EA	RANBP3 FBRS DIDO1 IRF6 RRP8 SUGP2 ZFYVE26 CNOT3	1.25e-04	198	170	8	950_DN
Drug	Hydrocortisone base [50-23-7]; Up 200; 11uM; MCF7; HT_HG-U133A	ZMYND8 UBXN6 SIRT3 IRF9 SCAPER CES3 QPCT EIF2AK1	1.25e-04	198	170	8	5284_UP
Drug	Glafenine hydrochloride [65513-72-6]; Up 200; 9.8uM; MCF7; HT_HG-U133A	FBRS IL17RC SIRT3 FARP2 STMN4 SEC24D VPS13D SCAPER	1.25e-04	198	170	8	7018_UP
Drug	Niflumic acid [4394-00-7]; Up 200; 14.2uM; MCF7; HT_HG-U133A	GRK5 ASH1L IRF6 RGS12 VPS13D SCAPER PLCG2 VPS13B	1.25e-04	198	170	8	7430_UP
Drug	Solanine alpha [20562-02-1]; Up 200; 4.6uM; MCF7; HT_HG-U133A	FKRP GRK5 CGA RGS12 STMN4 SEC24D SLC10A1 HRG	1.29e-04	199	170	8	4166_UP
Drug	Pirenzepine dihydrochloride [29868-97-1]; Up 200; 9.4uM; MCF7; HT_HG-U133A	ROCK2 RELN GRK5 IRF6 ITIH3 FARP2 FCER1A CNOT3	1.29e-04	199	170	8	7226_UP
Drug	alpha-Santonin [481-06-1]; Down 200; 16.2uM; PC3; HT_HG-U133A	RANBP3 SIPA1L3 FBRS ETV1 SEC24D CES3 MOB3B CEP170B	1.29e-04	199	170	8	4531_DN
Drug	ICI182,780; Up 200; 1uM; MCF7; HT_HG-U133A	SIPA1L3 IL17RC ZNF804A FCER1A SLCO1A2 SCAPER PAX1 CNOT3	1.34e-04	200	170	8	7534_UP
Drug	Haloperidol [52-86-8]; Down 200; 10.6uM; HL60; HG-U133A	ROCK2 RANBP3 DIDO1 TMCO6 VPS13D CES3 PRKCA EIF2AK1	1.34e-04	200	170	8	2039_DN
Drug	clozapine; Down 200; 10uM; MCF7; HT_HG-U133A	TNPO2 RANBP3 NUP98 IRF5 KAT2A SIRT3 EIF2AK1 SKAP2	1.34e-04	200	170	8	6947_DN
Disease	very low density lipoprotein particle size measurement	PDXDC1 ARID1A ADAM10 ITIH3 NCAN ANGPTL4	1.07e-04	133	165	6	EFO_0008594
Disease	alcohol use disorder (implicated_via_orthology)	GRK5 FBRS ARID1A RYR1 CLIC2 ANGPTL4 PRKCA	1.19e-04	195	165	7	DOID:1574 (implicated_via_orthology)
Disease	ocular hypertension, response to triamcinolone acetonide	IL17RC COL24A1 FRRS1 ANGPTL4	1.64e-04	49	165	4	EFO_0006954, EFO_1001069
Disease	Chronic Lymphocytic Leukemia	ARL11 FARP2 QPCT PLCG2	2.57e-04	55	165	4	C0023434
Disease	sensory peripheral neuropathy, remission	ETV1 PTPRT DLEC1	2.80e-04	23	165	3	EFO_0009785, MONDO_0002321
Disease	level of Phosphatidylcholine (18:1_20:3) in blood serum	PDXDC1 NCAN	4.59e-04	6	165	2	OBA_2045103
Disease	omega-3 polyunsaturated fatty acid measurement	PDXDC1 TMC4 MAU2 NCAN ANGPTL4	5.41e-04	118	165	5	EFO_0010119
Disease	triacylglycerol 56:7 measurement	MAU2 PTPRT NCAN	5.64e-04	29	165	3	EFO_0010434
Disease	platelet reactivity measurement	GRK5 PEAR1	6.41e-04	7	165	2	EFO_0004985
Disease	Cleft palate	SLC25A21 IRF6 MAU2 SCAPER	6.84e-04	71	165	4	HP_0000175
Disease	level of Phosphatidylinositol (16:0_18:2) in blood serum	TMC4 CNOT3	8.51e-04	8	165	2	OBA_2045153
Disease	Acute erythroleukemia - M6a subtype	FLT3 NUP98	8.51e-04	8	165	2	C2930975
Disease	Acute myeloid leukemia FAB-M6	FLT3 NUP98	8.51e-04	8	165	2	C2930976
Disease	Acute erythroleukemia - M6b subtype	FLT3 NUP98	8.51e-04	8	165	2	C2930977
Disease	Acute erythroleukemia	FLT3 NUP98	8.51e-04	8	165	2	C2930974
Disease	triacylglycerol 58:8 measurement	MAU2 PTPRT TMEM132E	9.85e-04	35	165	3	EFO_0010442
Disease	coronary aneurysm	GRK5 CSMD2 COL24A1	9.85e-04	35	165	3	EFO_1000881
Disease	Kunitz-type protease inhibitor 2 measurement	SIPA1L3 RYR1	1.36e-03	10	165	2	EFO_0008200
Disease	Asthma, Occupational	PRKCA HERC2	1.36e-03	10	165	2	C0264423
Disease	response to carboplatin, response to antineoplastic agent	SPEF2 PLCG2	1.36e-03	10	165	2	GO_0097327, GO_0097328
Disease	lymphocyte count	ROCK2 VMP1 FLT3 SPEF2 GRK5 ETV1 IRF5 OR2J2 SIRT3 PTPRT EOMES BNC1 XPO6 DDX18 MCM3AP QPCT MAP2K2 SKAP2	1.46e-03	1464	165	18	EFO_0004587
Disease	kidney disease (implicated_via_orthology)	NPHS1 KAT2A KL	1.57e-03	41	165	3	DOID:557 (implicated_via_orthology)
Disease	response to statin, myopathy	ERICH1 SLCO1A2	1.65e-03	11	165	2	EFO_0004145, GO_0036273
Disease	microfibrillar-associated protein 2 measurement	HRG C1R	1.65e-03	11	165	2	EFO_0801801
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	PDXDC1 ARID1A ADAM10 ITIH3 NCAN ANGPTL4	1.68e-03	224	165	6	EFO_0004530, EFO_0008317
Disease	total cholesterol measurement, very low density lipoprotein cholesterol measurement	PDXDC1 ARID1A ADAM10 ITIH3 NCAN ANGPTL4	1.68e-03	224	165	6	EFO_0004574, EFO_0008317
Disease	Colonic Neoplasms	SH3KBP1 EOMES HES1 MAP2K6 KDM1A	1.68e-03	152	165	5	C0009375
Disease	cholesteryl ester measurement, very low density lipoprotein cholesterol measurement	PDXDC1 ARID1A ADAM10 ITIH3 NCAN ANGPTL4	1.72e-03	225	165	6	EFO_0008317, EFO_0010351
Disease	unipolar depression, bipolar disorder	FAT4 ZMYND8 NFAM1 ITIH3 NCAN	1.88e-03	156	165	5	EFO_0003761, MONDO_0004985
Disease	multiple sclerosis	VMP1 TAGAP ARL11 SPEF2 UBXN6 IRF5 EOMES MMEL1 N4BP2 SKAP2	1.96e-03	594	165	10	MONDO_0005301
Disease	level of Phosphatidylinositol (16:0_18:1) in blood serum	PDXDC1 TMC4	1.98e-03	12	165	2	OBA_2045152
Disease	Congenital muscular dystrophy	FKRP RYR1	1.98e-03	12	165	2	cv:C0699743
Disease	acute myeloid leukemia (implicated_via_orthology)	FLT3 NUP98	1.98e-03	12	165	2	DOID:9119 (implicated_via_orthology)
Disease	Malignant tumor of colon	SH3KBP1 EOMES HES1 MAP2K6 KDM1A	2.05e-03	159	165	5	C0007102
Disease	platelet aggregation	GRK5 CSMD2 PEAR1	2.05e-03	45	165	3	GO_0070527
Disease	dihomo-linolenoylcarnitine (C20:3n3 or 6) measurement	PDXDC1 SLCO1A2	2.33e-03	13	165	2	EFO_0800547
Disease	cannabis dependence measurement	SEC24D DDX18 PAX1	2.47e-03	48	165	3	EFO_0008457
Disease	1-stearoyl-2-dihomo-linolenoyl-GPI (18:0/20:3n3 or 6) measurement	PDXDC1 TMC4	2.71e-03	14	165	2	EFO_0022085
Disease	diacylglycerol 38:4 measurement	TMC4 CNOT3	2.71e-03	14	165	2	EFO_0020066
Disease	calcium measurement	GRK5 MAU2 RGS12 FARP2 GRHL1 SLC22A8 QPCT MAP7D2 SKAP2 MAP2K6	2.92e-03	628	165	10	EFO_0004838
Disease	Malignant neoplasm of breast	NUP98 ARID1A ADAM10 EOMES N4BP2 DDX18 ANGPTL4 MAP7D2 HRG ZFYVE26 HES1 DLEC1 HERC2 VPS13B	2.93e-03	1074	165	14	C0006142
Disease	phosphatidylethanolamine measurement	PDXDC1 SGSM1 ADAM10 CNTN3 PLCG2	2.95e-03	173	165	5	EFO_0010228
Disease	Leukemia, Myelocytic, Acute	FLT3 CEBPD NUP98 PTPRT PSIP1	2.95e-03	173	165	5	C0023467
Disease	liver volume	MAU2 ARID1A	3.11e-03	15	165	2	EFO_0600048
Disease	Gastro-enteropancreatic neuroendocrine tumor	EOMES CIITA	3.11e-03	15	165	2	C2930967
Disease	peptide measurement	PTPRT SLCO1A2 SCAPER DLEC1	3.33e-03	109	165	4	EFO_0010520
Disease	very low density lipoprotein cholesterol measurement	ARID1A ADAM10 RGS12 ITIH3 NCAN ANGPTL4	3.52e-03	260	165	6	EFO_0008317
Disease	level of triacylglycerol (56:6) in blood serum	MAU2 NCAN	3.54e-03	16	165	2	OBA_2020007
Disease	T-Cell Lymphoma	ARID1A KDM1A	3.54e-03	16	165	2	C0079772
Disease	triglycerides in medium VLDL measurement	ARID1A ITIH3 ANGPTL4	3.64e-03	55	165	3	EFO_0022155
Disease	factor VII activating protease measurement	SGSM1 ZMYND8 EXOC6B	3.64e-03	55	165	3	EFO_0009368
Disease	triglycerides in large VLDL measurement	ARID1A ITIH3 ANGPTL4	3.83e-03	56	165	3	EFO_0022178
Disease	alcoholic liver cirrhosis	TMC4 TAF4B	4.00e-03	17	165	2	EFO_1000802
Disease	Psoriasis	TAGAP CYP2S1 VNN2	4.03e-03	57	165	3	C0033860
Disease	Pustulosis of Palms and Soles	TAGAP CYP2S1 VNN2	4.03e-03	57	165	3	C0030246
Disease	level of Phosphatidylinositol (18:0_18:1) in blood serum	TMC4 CNOT3	4.48e-03	18	165	2	OBA_2045155
Disease	chronic lymphocytic leukemia	FARP2 EOMES QPCT MAP2K2	4.55e-03	119	165	4	EFO_0000095
Disease	triglycerides to total lipids in large HDL percentage	ARID1A RGS12 ANGPTL4	4.65e-03	60	165	3	EFO_0022330
Disease	cholesterol to total lipids in IDL percentage	PDXDC1 ARID1A ANGPTL4	4.65e-03	60	165	3	EFO_0022233
Disease	diacylglycerol 38:3 measurement	TMC4 CNOT3	4.99e-03	19	165	2	EFO_0020065
Disease	phospholipids in large VLDL measurement	ARID1A ITIH3 ANGPTL4	5.10e-03	62	165	3	EFO_0022169
Disease	osteoarthritis, hip, osteoarthritis, knee	USP21 MOB3B MAP2K6	5.10e-03	62	165	3	EFO_0004616, EFO_1000786
Disease	Acute Myeloid Leukemia, M1	FLT3 CEBPD NUP98 PSIP1	5.41e-03	125	165	4	C0026998
Disease	Acute Myeloid Leukemia (AML-M2)	FLT3 CEBPD NUP98 PSIP1	5.41e-03	125	165	4	C1879321
Disease	cholesteryl esters to total lipids in medium VLDL percentage	PDXDC1 RGS12 ANGPTL4	5.57e-03	64	165	3	EFO_0022253

Protein segments in the cluster

Peptide	Gene	Start	Entry
QTPAAPKQVFPFRDI	TTF1	851	Q15361
AQLLPAFVGPKLPQV	nan	96	Q75L30
PLDPVQPGKKFFNLN	ACO1	11	P21399
EKVLQRLFPPVPSGQ	ERICH1	11	Q86X53
GVQSFFPEPFVNTLP	EOMES	471	O95936
LKQQVPFAKPLPTFA	EP400	2341	Q96L91
LFFAPDGVLAVPQKP	FCER1A	16	P12319
PILQPEIEIPSFKQG	ASH1L	866	Q9NR48
PILIIKQGFEPPIFT	AVIL	691	O75366
LFEIQPQGSPPFLVN	ANGPTL4	201	Q9BY76
QLFPGSVIDPPAVNL	BIRC6	1726	Q9NR09
PPLTQALIPGDVFAK	CSMD2	3261	Q7Z408
PGNIKDQPRPAFSAI	C1QA	106	P02745
PTNPFRFPNIGVEKF	ADAM10	286	O14672
EFALGPVSGPQAFPK	CIITA	961	P33076
NAPVFPDPSIVVTFK	FAT4	131	Q6V0I7
FQFFNPLPPALIGSL	BNC1	246	Q01954
GVLFPNLKTVQPVLP	BNC1	476	Q01954
SKLVDVPFQVEFPAP	APBB1	521	O00213
VPFQVEFPAPKNELV	APBB1	526	O00213
KSPFKIPPVTFINEG	ANGPTL1	261	O95841
QEPGKFTPENIDPFL	CHI3L2	41	Q15782
IPEASLNFQKVPPGS	CEP170B	1386	Q9Y4F5
PPNVVLGVTNPFFIK	DENND6B	326	Q8NEG7
IPQKLFGEVTSPLFP	C1R	21	P00736
QKALFSIGFPVPKPI	ACAD11	91	Q709F0
LLNGPPQFSTAPEIK	CNOT3	521	O75175
PKLPNGVFTPDFQEF	MAP2K2	331	P36507
NEEKPAIAPPVFVFQ	RANBP3	6	Q9H6Z4
PPTLFGLTEFNPEIQ	RCC1L	381	Q96I51
LLDLIGAPNPTFPNF	QPCT	246	Q16769
LGSPPFEKPNIEQGV	KAT2A	221	Q92830
PTCVGVPFPKNFLQI	MOB3B	136	Q86TA1
FPPGSVEATQPVLKQ	ARID1A	1641	O14497
LPTVGFNVEPLKAPG	ARL11	41	Q969Q4
ALLFPQIEGIKIQPF	FBXO22	176	Q8NEZ5
APIKASFTVNVLFPP	NPHS1	226	O60500
IPFDVAKSRIQGPQP	SLC25A21	226	Q9BQT8
TNEFKFLKPIIPNFP	PCDHB13	761	Q9Y5F0
EFGFLPNPVAVKPLT	NUP98	1176	P52948
KGEVLPLPEANFPSF	HRG	466	P04196
EPAREVPLQGKPFFT	MAGI1	446	Q96QZ7
VPLQGKPFFTRNPSE	MAGI1	451	Q96QZ7
LQDLLDFTGPPTFPK	MAP7D2	686	Q96T17
KPLPAVAFNVNNLPF	HERC2	2261	O95714
FPTNVGTPFPKNFLQ	MOB3A	136	Q96BX8
NVGTLPSKPPFRFGQ	MCM3AP	21	O60318
DKNETFLPFGIPLPF	HPS5	516	Q9UPZ3
PTVSGLFNIPPAFQL	CYP2S1	476	Q96SQ9
NKVPGPLFASLQNPE	PEAR1	836	Q5VY43
QELPGSDPVFKAVPV	PDXDC1	396	Q6P996
SEPNIPFPPQGFKQE	ETV1	216	P50549
IPQLQAKGPVPSFSE	KMT2E	1306	Q8IZD2
PFAAAVGQEKPVFEP	KRI1	481	Q8N9T8
QFPFQDIELEKQPFP	EXOC6B	471	Q9Y2D4
LFQKGQTNTPPPFEI	IRF5	381	Q13568
SFVFILEPKQQGDPP	PLCG2	871	P16885
FIQSLFLVPPTGNPA	MON2	396	Q7Z3U7
LQPPSENSPDQGKFI	OR2J2	261	O76002
LPQVALSFGFKVPPF	DDX18	606	Q9NVP1
LPVGITFFKEENSPP	HCN3	111	Q9P1Z3
QIVFPAGILQPPFFS	MMEL1	581	Q495T6
AGILQPPFFSKEQPQ	MMEL1	586	Q495T6
FLKPIIPNFLPQSTG	PCDHB12	766	Q9Y5F1
QYSKPGFVNILLPPD	RELN	2616	P78509
VRQVKFLNPPEAGPI	PTPRT	1066	O14522
PFQGVLLPPEKVQAG	PRDM6	276	Q9NQX0
LQENPFFSQPGAPIL	CGA	36	P01215
TGDPFSQPIKFPING	SCYL3	491	Q8IZE3
NFTLPPNFGKRPTDL	SLC10A1	11	Q14973
GNNFLPLTIPIPKTF	ITPRIPL1	496	Q6GPH6
FPATPAVNGLEKPAL	PAX1	331	P15863
TILLNSPGPFPFIQD	FLT3	526	P36888
SIQKPEVFFLPDLPT	ASPHD2	161	Q6ICH7
LQGAFQPKSTNPELP	FBRS	41	Q9HAH7
KPFIDLDTQPVLFIP	GRHL1	461	Q9NZI5
PLGVLKQQPPAVQFV	KDM1A	626	O60341
QSLLLPGPIVVPNFF	C2CD3	2266	Q4AC94
VPNFFLPPQQLEASL	C2CD3	2276	Q4AC94
AKGPPTNVEPFFINL	DOCK11	386	Q5JSL3
PSTFLPKQEGPFFLD	CAPN7	786	Q9Y6W3
GLRQFFKQLPSPPFL	CEBPD	246	P49716
KEPLQQPTFPFAVAN	EIF2AK1	51	Q9BQI3
KIPGPIISQPNAFPF	FRRS1	156	Q6ZNA5
GGPFPAVKFPIKDIQ	IDI2-AS1	51	Q9NZ38
GRKVNFAELPVPPGF	CC2D1B	431	Q5T0F9
APPLLDPIVQQFGQF	DIDO1	1356	Q9BTC0
FIELPEEFPQFPNKV	DENND5B	376	Q6ZUT9
PPSVILGVTNPFFAK	DENND6A	346	Q8IWF6
PEQTVKTFPLPAVGL	C17orf80	86	Q9BSJ5
VNLLIPFQGKPKPQA	MYBPHL	71	A2RUH7
GFQVPEVRKKFTPNP	MAP6D1	171	Q9H9H5
FQGLGPPPKFQVTLN	IRF9	336	Q00978
FYQKLIEKNGFPPLP	KL	496	Q9UEF7
FIDFPKPLIAVVNGP	ECI2	231	O75521
ALLSQNPEKFVYPVP	MPP1	301	Q00013
IPLTPKQAQALGIPF	FAM186A	1301	A6NE01
LQPLVPLPFAGFVAQ	FKRP	446	Q9H9S5
FKELNVFGPNGTLPP	GRK5	521	P34947
LVNVFLGIPFAQPPL	CES3	56	Q6UWW8
VLRLAVKFFPPDPGQ	FARP2	116	O94887
FVEQPPFGILPSVFE	DLEC1	531	Q9Y238
KQPGTDAFQKPVPLE	ZMYND8	166	Q9ULU4
PLVKITGEVQPFIPN	SLC22A8	461	Q8TCC7
AFLLPVANPPNAIVF	SLC13A1	526	Q9BZW2
AGTPPLQVNEEKFPA	SCAPER	386	Q9BY12
LQAVFPFKPPQRIEA	MAU2	51	Q9Y6X3
VEPNTKLFPAVFVLP	RYR1	1541	P21817
LQFDPGPVLNFKPCF	CFAP47	411	Q6ZTR5
PVFIKEPSNSIFPVG	CNTN3	26	Q9P232
PGTNPPFLVYNKELK	CLIC2	66	O15247
VPVFTLPSQLPDFLG	IL17RC	721	Q8NAC3
PTRVGVPFPKNFQQV	MOB3C	136	Q70IA8
SEFVLLGFPAPAPLQ	OR6A2	11	O95222
PFPTDKIVNLPVDDF	NFE2	236	Q16621
VVPAPDGQFAFLIPN	HES1	221	Q14469
FGPVSLEQVKFPGPE	IRF6	266	O14896
PGLKIPKEAFEQPQT	MAP2K6	11	P52564
FSPNVFFPIIILPTN	FREM3	1176	P0C091
FFPIIILPTNDEQPK	FREM3	1181	P0C091
FPANLQLPPGTVLIK	TAF4B	106	Q92750
KGVPFPVLQRFPTEV	HSF5	251	Q4G112
FINGNIKVFPDPPPS	SPEF2	1436	Q9C093
IAKLQSEPLPFQAPG	TRDMT1	166	O14717
PFPEEVFPAVQGKTK	TAGAP	421	Q8N103
PTEDFLPLPTGFLQV	TMEM132E	866	Q6IEE7
FDKFFTRGQPVLTPP	PRKCA	626	P17252
FPPIAAQDLPFVLKA	SKAP2	106	O75563
HFFAPQGLPVVPKNV	ITIH3	271	Q06033
QKFPGINYPVLTPNL	HMGCL	96	P35914
EPPQSPQKLLLFGFT	NFAM1	156	Q8NET5
SPGVFLVPKVTPNLE	NCAN	801	O14594
GVFPDNFVKLLPPDF	SH3KBP1	316	Q96B97
IFQEPGALPFTPKNI	SIPA1L3	726	O60292
VVKPDIVFFGEPLPQ	SIRT3	286	Q9NTG7
GFIPFLFNQLAPESP	OCSTAMP	356	Q9BR26
IPFFFLPNTLPKEGL	SLCO1A2	261	P46721
VILKPPSFDGVPEFN	STMN4	66	Q9H169
TPPPGFEKILFEQQI	SPRYD7	181	Q5W111
PPELIQGIFNVPSFA	SEC24D	936	O94855
FAPPCLQVLNTPKGI	SLCO4A1	91	Q96BD0
GFFPTNFVQIIKPLP	SH3RF1	181	Q7Z6J0
TNQLPQPDVFPLFKD	AATF	251	Q9NY61
FVPEPFDGANVVPNL	ASPRV1	101	Q53RT3
IKGPLPNTKTQFFIP	COL10A1	31	Q03692
ETPFVKILPVNLGQP	COL24A1	91	Q17RW2
GAVKPPTNKLPIFFF	PSIP1	31	O75475
PQFNVPEKPELVTFN	VNN2	186	O95498
QVTPPGFQLVFLPFA	XRCC6	426	P12956
VFQPSPLASQFELPG	UBXN6	276	Q9BZV1
PLSPGPQKTFQALQE	ZSCAN10	151	Q96SZ4
PVNIQPRVGSKLPFA	USP21	16	Q9UK80
LVFPLGKEQPAIAPI	UTP14C	156	Q5TAP6
AQQIFKIPPPSINFT	UNC80	1666	Q8N2C7
PEPTGFLLKFNPSLN	ZDHHC13	196	Q8IUH4
VEGSFAQPPLNAPKR	RGS12	586	O14924
LFTFQPPDAKDGLPQ	SYNPO2	976	Q9UMS6
PSIFIAGVNFVLPPV	TMC4	396	Q7Z404
FPPPVADFIKQECLN	TNPO2	81	O14787
PGTEDIQFPIQKIPL	SUGP2	286	Q8IX01
KPRLGPFQIPESAIQ	FAM90A2P	306	Q658T7
NQPFFVTSLPDDKIP	TPP2	946	P29144
TFPIPKAFVGNQLPF	ROCK2	396	O75116
QPGPKLNPGVAVEFA	TMCO6	246	Q96DC7
LFDFQKTGPPLVGPK	RRP8	426	O43159
VSQDGIQRPPFRFPK	SGSM1	341	Q2NKQ1
KDFKVQGIFPVPPGS	ZNF518A	831	Q6AHZ1
FPIPKAFVGNQLPFV	ROCK1	381	Q13464
VPAGKIIIPPNFQEA	VPS13B	3011	Q7Z7G8
QEPGQVFKPFLPSII	XPO6	901	Q96QU8
EFQVKPKNPLGEGPV	ABI3BP	901	Q7Z7G0
DAPPFQLGKPRFQQT	SFXN5	21	Q8TD22
KESPPEVFIEGIFQP	ZFYVE26	2196	Q68DK2
VNGAVFPKPFVEKPV	PPIP5K1	186	Q6PFW1
SGILNTQPPLPFKEA	ZNF804A	996	Q7Z570
AVPGIGPSLQKPFQE	VMP1	326	Q96GC9
PQVIFPDDFKFKNPV	VPS13D	716	Q5THJ4
PPELAFQLNELFGPV	N4BP2	1381	Q86UW6
AVNLVIPFQGKPRPE	MYBPC1	856	Q00872