Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR3	3.98e-05	4	52	2	GO:0005219
GeneOntologyMolecularFunction	transporter activity	SEC61A2 ABCC3 ABCC1 ATP7A TMEM94 ATP10B CATSPER3 DISP1 SLC26A6 RYR1 RYR3 SLC4A2	9.18e-05	1289	52	12	GO:0005215
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR3	9.91e-05	6	52	2	GO:0048763
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	ABCC3 ABCC1 ATP7A TMEM94 CATSPER3 SLC26A6 RYR1 RYR3 SLC4A2	1.33e-04	758	52	9	GO:0015318
GeneOntologyMolecularFunction	ATP-dependent activity	ACSL6 ABCC3 ABCC1 ATP7A TMEM94 NAE1 ATP10B DNAH1	1.74e-04	614	52	8	GO:0140657
GeneOntologyMolecularFunction	ABC-type glutathione S-conjugate transporter activity	ABCC3 ABCC1	1.84e-04	8	52	2	GO:0015431
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCC3 ABCC1 ATP7A TMEM94	1.86e-04	109	52	4	GO:0042626
GeneOntologyMolecularFunction	transmembrane transporter activity	SEC61A2 ABCC3 ABCC1 ATP7A TMEM94 CATSPER3 DISP1 SLC26A6 RYR1 RYR3 SLC4A2	1.88e-04	1180	52	11	GO:0022857
GeneOntologyMolecularFunction	ATPase-coupled lipid transmembrane transporter activity	ABCC3 ABCC1	2.37e-04	9	52	2	GO:0034040
GeneOntologyMolecularFunction	ATPase-coupled inorganic anion transmembrane transporter activity	ABCC3 ABCC1	2.95e-04	10	52	2	GO:0043225
GeneOntologyMolecularFunction	chloride:bicarbonate antiporter activity	SLC26A6 SLC4A2	5.09e-04	13	52	2	GO:0140900
GeneOntologyMolecularFunction	bicarbonate:monoatomic anion antiporter activity	SLC26A6 SLC4A2	5.09e-04	13	52	2	GO:0140829
GeneOntologyMolecularFunction	sulfur compound transmembrane transporter activity	ABCC3 ABCC1 SLC26A6	5.39e-04	61	52	3	GO:1901682
GeneOntologyMolecularFunction	ABC-type xenobiotic transporter activity	ABCC3 ABCC1	6.83e-04	15	52	2	GO:0008559
GeneOntologyMolecularFunction	efflux transmembrane transporter activity	ABCC1 SLC26A6	7.80e-04	16	52	2	GO:0015562
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR1 RYR3	9.91e-04	18	52	2	GO:0015278
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	ABCC3 ABCC1 SLC26A6 SLC4A2	1.02e-03	171	52	4	GO:0015103
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ABCC3 ABCC1 ATP7A TMEM94	1.18e-03	178	52	4	GO:0015399
GeneOntologyMolecularFunction	sphingolipid transporter activity	ABCC1 ATP10B	1.23e-03	20	52	2	GO:0046624
GeneOntologyMolecularFunction	protease binding	A2M SART3 PSAP RYR1	1.26e-03	181	52	4	GO:0002020
GeneOntologyMolecularFunction	active transmembrane transporter activity	ABCC3 ABCC1 ATP7A TMEM94 SLC26A6 SLC4A2	1.45e-03	477	52	6	GO:0022804
GeneOntologyMolecularFunction	monocarboxylic acid transmembrane transporter activity	ABCC3 ABCC1 SLC26A6	1.67e-03	90	52	3	GO:0008028
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	RYR1 RYR3	2.95e-03	31	52	2	GO:0099604
GeneOntologyMolecularFunction	bicarbonate transmembrane transporter activity	SLC26A6 SLC4A2	3.14e-03	32	52	2	GO:0015106
GeneOntologyMolecularFunction	solute:inorganic anion antiporter activity	SLC26A6 SLC4A2	3.14e-03	32	52	2	GO:0005452
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR1 RYR3	3.34e-03	33	52	2	GO:0005217
GeneOntologyMolecularFunction	xenobiotic transmembrane transporter activity	ABCC3 ABCC1	3.54e-03	34	52	2	GO:0042910
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	ABCC3 ABCC1 ATP7A ATP10B AGAP7P AGAP4 AGAP6	3.78e-03	775	52	7	GO:0017111
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP7A TMEM94	3.96e-03	36	52	2	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP7A TMEM94	3.96e-03	36	52	2	GO:0015662
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	ATP7A TMEM94 CATSPER3 SLC26A6 RYR1 RYR3 SLC4A2	4.28e-03	793	52	7	GO:0015075
GeneOntologyMolecularFunction	calcium channel activity	CATSPER3 RYR1 RYR3	4.62e-03	129	52	3	GO:0005262
GeneOntologyMolecularFunction	ligase activity, forming carbon-sulfur bonds	ACSL6 NAE1	5.11e-03	41	52	2	GO:0016877
GeneOntologyMolecularFunction	pyrophosphatase activity	ABCC3 ABCC1 ATP7A ATP10B AGAP7P AGAP4 AGAP6	5.81e-03	839	52	7	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	ABCC3 ABCC1 ATP7A ATP10B AGAP7P AGAP4 AGAP6	5.84e-03	840	52	7	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	ABCC3 ABCC1 ATP7A ATP10B AGAP7P AGAP4 AGAP6	5.84e-03	840	52	7	GO:0016818
GeneOntologyMolecularFunction	GTPase activator activity	ARHGAP23 AGAP7P AGAP4 AGAP6	5.97e-03	279	52	4	GO:0005096
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CATSPER3 RYR1	6.40e-03	46	52	2	GO:0005245
GeneOntologyMolecularFunction	enzyme activator activity	PPP2R5C PSAP ARHGAP23 AGAP7P AGAP4 AGAP6	6.93e-03	656	52	6	GO:0008047
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	ABCC3 ABCC1 SLC26A6 SLC4A2	7.07e-03	293	52	4	GO:0008514
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	ATP7A TMEM94 CATSPER3 RYR1 RYR3	7.09e-03	465	52	5	GO:0046873
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CATSPER3 RYR1 RYR3	7.15e-03	151	52	3	GO:0015085
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCC3 ABCC1	7.23e-03	49	52	2	GO:0140359
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	ATP7A TMEM94 SLC26A6 SLC4A2	7.77e-03	301	52	4	GO:0022853
GeneOntologyMolecularFunction	ATPase-coupled monoatomic cation transmembrane transporter activity	ATP7A TMEM94	1.14e-02	62	52	2	GO:0019829
GeneOntologyCellularComponent	basal part of cell	ABCC3 ABCC1 ATP7A DLG4 ITGA2 SLC26A6 SLC4A2	3.97e-05	378	52	7	GO:0045178
GeneOntologyCellularComponent	basolateral plasma membrane	ABCC3 ABCC1 ATP7A DLG4 SLC26A6 SLC4A2	1.38e-04	320	52	6	GO:0016323
GeneOntologyCellularComponent	junctional membrane complex	RYR1 RYR3	2.16e-04	9	52	2	GO:0030314
GeneOntologyCellularComponent	basal plasma membrane	ABCC3 ABCC1 ATP7A DLG4 SLC26A6 SLC4A2	2.39e-04	354	52	6	GO:0009925
GeneOntologyCellularComponent	calcium channel complex	CATSPER3 RYR1 RYR3	7.99e-04	73	52	3	GO:0034704
MousePheno	impaired balance	PPP2R5C ATP7A PSAP DLG4 OTOG	2.94e-05	121	42	5	MP:0001525
MousePheno	fused cornea and lens	AGAP7P AGAP4 AGAP6	4.89e-05	24	42	3	MP:0001307
MousePheno	abnormal circulating mineral level	SEC61A2 ATP7A ARHGAP23 NAE1 DLG4 PRKDC AGAP7P AGAP4 AGAP6 CYRIB RYR1	1.10e-04	982	42	11	MP:0006357
MousePheno	absent pinna reflex	AGAP7P AGAP4 AGAP6 OTOG	1.43e-04	89	42	4	MP:0006358
MousePheno	abnormal skin coloration	ATP7A AGAP7P AGAP4 AGAP6 DNAH1	2.04e-04	182	42	5	MP:0011239
MousePheno	abnormal mineral level	SEC61A2 ATP7A ARHGAP23 NAE1 DLG4 PRKDC AGAP7P AGAP4 AGAP6 CYRIB RYR1	2.28e-04	1066	42	11	MP:0000192
MousePheno	abnormal pinna reflex	AGAP7P AGAP4 AGAP6 OTOG	2.33e-04	101	42	4	MP:0001485
MousePheno	abnormal mineral homeostasis	SEC61A2 ATP7A ARHGAP23 NAE1 DLG4 PRKDC AGAP7P AGAP4 AGAP6 CYRIB RYR1	2.47e-04	1076	42	11	MP:0005636
MousePheno	abnormal sensory capabilities/reflexes/nociception	SEC61A2 ACSL6 ABCC3 FLT1 PPP2R5C PSAP DLG4 AGAP7P SSTR5 AGAP4 AGAP6 RYR1 OTOG	2.78e-04	1486	42	13	MP:0002067
MousePheno	abnormal tooth morphology	SMG1 AGAP7P AGAP4 AGAP6 DISP1 SLC4A2	3.48e-04	318	42	6	MP:0002100
MousePheno	abnormal dental arch morphology	SMG1 AGAP7P AGAP4 AGAP6 DISP1 SLC4A2	3.54e-04	319	42	6	MP:0030254
Domain	Ryanrecept_TM4-6	RYR1 RYR3	2.19e-05	3	51	2	IPR009460
Domain	RyR	RYR1 RYR3	2.19e-05	3	51	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR3	2.19e-05	3	51	2	IPR003032
Domain	RR_TM4-6	RYR1 RYR3	2.19e-05	3	51	2	PF06459
Domain	Ryan_recept	RYR1 RYR3	2.19e-05	3	51	2	IPR013333
Domain	Multidrug-R_assoc	ABCC3 ABCC1	4.37e-05	4	51	2	IPR005292
Domain	ArfGap	AGAP7P AGAP4 AGAP6	6.67e-05	29	51	3	SM00105
Domain	ArfGap	AGAP7P AGAP4 AGAP6	6.67e-05	29	51	3	PF01412
Domain	ARFGAP	AGAP7P AGAP4 AGAP6	6.67e-05	29	51	3	PS50115
Domain	ArfGAP	AGAP7P AGAP4 AGAP6	6.67e-05	29	51	3	IPR001164
Domain	FATC	SMG1 PRKDC	7.27e-05	5	51	2	PF02260
Domain	RIH_assoc	RYR1 RYR3	1.09e-04	6	51	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR3	1.09e-04	6	51	2	IPR013662
Domain	RIH_dom	RYR1 RYR3	1.09e-04	6	51	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR3	1.09e-04	6	51	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR3	1.09e-04	6	51	2	IPR015925
Domain	FAT	SMG1 PRKDC	1.09e-04	6	51	2	PS51189
Domain	FATC	SMG1 PRKDC	1.09e-04	6	51	2	PS51190
Domain	-	RYR1 RYR3	1.09e-04	6	51	2	1.25.10.30
Domain	FATC_dom	SMG1 PRKDC	1.09e-04	6	51	2	IPR003152
Domain	RYDR_ITPR	RYR1 RYR3	1.09e-04	6	51	2	PF01365
Domain	PIK_FAT	SMG1 PRKDC	1.09e-04	6	51	2	IPR014009
Domain	Ins145_P3_rec	RYR1 RYR3	1.09e-04	6	51	2	PF08709
Domain	FATC	SMG1 PRKDC	1.09e-04	6	51	2	SM01343
Domain	ATPase_P-typ_transduc_dom_A	ATP7A TMEM94 ATP10B	1.40e-04	37	51	3	IPR008250
Domain	E1-E2_ATPase	ATP7A TMEM94 ATP10B	1.40e-04	37	51	3	PF00122
Domain	ARM-type_fold	SMG1 PPP2R5C CTNNBL1 PRKDC CUL7 RYR3	3.10e-04	339	51	6	IPR016024
Domain	MIR	RYR1 RYR3	3.24e-04	10	51	2	PS50919
Domain	MIR	RYR1 RYR3	3.24e-04	10	51	2	PF02815
Domain	MIR	RYR1 RYR3	3.24e-04	10	51	2	SM00472
Domain	MIR_motif	RYR1 RYR3	3.24e-04	10	51	2	IPR016093
Domain	PI3/4_kinase_CS	SMG1 PRKDC	7.50e-04	15	51	2	IPR018936
Domain	ARM-like	SMG1 PPP2R5C CTNNBL1 PRKDC CUL7	8.30e-04	270	51	5	IPR011989
Domain	-	SMG1 PRKDC	8.56e-04	16	51	2	1.10.1070.11
Domain	PI3Kc	SMG1 PRKDC	8.56e-04	16	51	2	SM00146
Domain	PI3/4_kinase_cat_dom	SMG1 PRKDC	1.09e-03	18	51	2	IPR000403
Domain	PI3_PI4_kinase	SMG1 PRKDC	1.09e-03	18	51	2	PF00454
Domain	PI3_4_KINASE_3	SMG1 PRKDC	1.09e-03	18	51	2	PS50290
Domain	PI3_4_KINASE_1	SMG1 PRKDC	1.09e-03	18	51	2	PS00915
Domain	PI3_4_KINASE_2	SMG1 PRKDC	1.09e-03	18	51	2	PS00916
Domain	ABC_membrane	ABCC3 ABCC1	1.94e-03	24	51	2	PF00664
Domain	ABC_TM1F	ABCC3 ABCC1	2.64e-03	28	51	2	PS50929
Domain	ABC1_TM_dom	ABCC3 ABCC1	2.64e-03	28	51	2	IPR011527
Domain	-	PPP2R5C CTNNBL1 PRKDC CUL7	3.14e-03	222	51	4	1.25.10.10
Domain	-	ATP7A ATP10B	3.44e-03	32	51	2	3.40.1110.10
Domain	-	ATP7A ATP10B	3.44e-03	32	51	2	2.70.150.10
Domain	Ion_trans_dom	CATSPER3 RYR1 RYR3	3.73e-03	114	51	3	IPR005821
Domain	Ion_trans	CATSPER3 RYR1 RYR3	3.73e-03	114	51	3	PF00520
Domain	ATPase_P-typ_cyto_domN	ATP7A ATP10B	4.11e-03	35	51	2	IPR023299
Domain	P_typ_ATPase	ATP7A ATP10B	4.34e-03	36	51	2	IPR001757
Domain	ATPase_P-typ_P_site	ATP7A ATP10B	4.34e-03	36	51	2	IPR018303
Domain	ATPASE_E1_E2	ATP7A ATP10B	4.34e-03	36	51	2	PS00154
Pathway	BIOCARTA_MRP_PATHWAY	ABCC3 ABCC1	8.21e-05	5	41	2	MM1586
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	A2M ABCC3 ABCC1 ATP7A ATP10B SLC26A6 RYR1 RYR3 SLC4A2	1.18e-04	681	41	9	MM14985
Pathway	BIOCARTA_MRP_PATHWAY	ABCC3 ABCC1	1.23e-04	6	41	2	M22078
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	A2M ABCC3 ABCC1 ATP7A ATP10B SLC26A6 RYR1 RYR3 SLC4A2	2.13e-04	736	41	9	M27287
Pathway	REACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES	ABCC3 ABCC1	2.29e-04	8	41	2	M48022
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	RYR1 RYR3	4.46e-04	11	41	2	M47958
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP7P AGAP4 AGAP6	2.63e-07	9	52	3	12640130
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP7P AGAP4 AGAP6	3.75e-07	10	52	3	20664521
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP7P AGAP4 AGAP6	5.16e-07	11	52	3	15381706
Pubmed	The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.	AGAP7P AGAP4 AGAP6	8.92e-07	13	52	3	27713690
Pubmed	GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.	AGAP7P AGAP4 AGAP6	1.13e-06	14	52	3	22453919
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SART3 SMG1 KMT2C PPP2R5C SPIRE1 AGAP7P AGAP4 AGAP6	1.14e-06	529	52	8	14621295
Pubmed	Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene.	RYR1 RYR3	2.19e-06	2	52	2	12565913
Pubmed	Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors.	RYR1 RYR3	2.19e-06	2	52	2	9489997
Pubmed	Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.	RYR1 RYR3	2.19e-06	2	52	2	9192302
Pubmed	The block of ryanodine receptors selectively inhibits fetal myoblast differentiation.	RYR1 RYR3	2.19e-06	2	52	2	12640042
Pubmed	Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.	RYR1 RYR3	2.19e-06	2	52	2	7556644
Pubmed	Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion.	RYR1 RYR3	2.19e-06	2	52	2	14592949
Pubmed	Differential Expression of VEGFA Isoforms Regulates Metastasis and Response to Anti-VEGFA Therapy in Sarcoma.	FLT1 PRKDC	2.19e-06	2	52	2	28377452
Pubmed	Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.	RYR1 RYR3	2.19e-06	2	52	2	15894801
Pubmed	Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors.	RYR1 RYR3	2.19e-06	2	52	2	9799464
Pubmed	Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3.	RYR1 RYR3	2.19e-06	2	52	2	9817784
Pubmed	Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development.	RYR1 RYR3	2.19e-06	2	52	2	17118445
Pubmed	RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.	RYR1 RYR3	2.19e-06	2	52	2	11500519
Pubmed	[Expression of ATP-binding Cassette Proteins Pgp, MRP1, and MRP3 in Malignant and Benign Ovarian Lesions].	ABCC3 ABCC1	6.57e-06	3	52	2	27739315
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR3	6.57e-06	3	52	2	18403125
Pubmed	Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.	RYR1 RYR3	6.57e-06	3	52	2	11171121
Pubmed	Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells.	ABCC3 ABCC1	6.57e-06	3	52	2	11820781
Pubmed	Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.	RYR1 RYR3	6.57e-06	3	52	2	18313230
Pubmed	Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice.	PSAP RYR1	6.57e-06	3	52	2	27655403
Pubmed	The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis.	ABCC3 ABCC1	6.57e-06	3	52	2	12628490
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR3	6.57e-06	3	52	2	18434746
Pubmed	Increased multidrug resistance-associated protein activity in mononuclear cells of patients with systemic lupus erythematosus.	ABCC3 ABCC1	6.57e-06	3	52	2	18799096
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR3	6.57e-06	3	52	2	9204703
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR3	6.57e-06	3	52	2	7876312
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR3	6.57e-06	3	52	2	21881589
Pubmed	Targeted ablation of Abcc1 or Abcc3 in Abcc6(-/-) mice does not modify the ectopic mineralization process.	ABCC3 ABCC1	6.57e-06	3	52	2	17845218
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR3	6.57e-06	3	52	2	12213830
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR3	6.57e-06	3	52	2	9242641
Pubmed	Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception.	ABCC3 ABCC1	6.57e-06	3	52	2	15886284
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR3	6.57e-06	3	52	2	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR3	6.57e-06	3	52	2	10788707
Pubmed	ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.	ABCC3 ABCC1	6.57e-06	3	52	2	21799180
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR3	6.57e-06	3	52	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR3	6.57e-06	3	52	2	7621815
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR3	6.57e-06	3	52	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR3	6.57e-06	3	52	2	11159936
Pubmed	Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function.	ABCC3 ABCC1	6.57e-06	3	52	2	17494643
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR3	6.57e-06	3	52	2	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR3	6.57e-06	3	52	2	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR3	6.57e-06	3	52	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR3	6.57e-06	3	52	2	7635066
Pubmed	Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.	A2M SEC61A2 PSAP PRKDC RYR3	1.10e-05	195	52	5	17110338
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR1 RYR3	1.31e-05	4	52	2	22100703
Pubmed	Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine.	SLC26A6 SLC4A2	1.31e-05	4	52	2	11842009
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR3	1.31e-05	4	52	2	18206662
Pubmed	Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress.	ABCC3 ABCC1	1.31e-05	4	52	2	18038766
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR3	1.31e-05	4	52	2	23413940
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR3	1.31e-05	4	52	2	9384575
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR3	1.31e-05	4	52	2	9607712
Pubmed	Regulation of mRNA expression of MDR1, MRP1, MRP2 and MRP3 by prototypical microsomal enzyme inducers in primary cultures of human and rat hepatocytes.	ABCC3 ABCC1	1.31e-05	4	52	2	16946557
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR3	1.31e-05	4	52	2	23482488
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR3	2.19e-05	5	52	2	23918386
Pubmed	Efflux protein expression in human stem cell-derived retinal pigment epithelial cells.	ABCC3 ABCC1	2.19e-05	5	52	2	22272278
Pubmed	Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.	FLT1 ITGA2	2.19e-05	5	52	2	21596751
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR3	2.19e-05	5	52	2	19011160
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR3	3.28e-05	6	52	2	19549818
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR3	3.28e-05	6	52	2	26025922
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR3	3.28e-05	6	52	2	23463619
Pubmed	Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers.	RYR1 RYR3	3.28e-05	6	52	2	10444070
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR3	3.28e-05	6	52	2	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR3	3.28e-05	6	52	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR3	3.28e-05	6	52	2	25966694
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR3	3.28e-05	6	52	2	19009018
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR3	3.28e-05	6	52	2	16844763
Pubmed	Expressions of hepatobiliary organic anion transporters and bilirubin-conjugating enzyme in differentiating embryonic stem cells.	ABCC3 ABCC1	3.28e-05	6	52	2	12951053
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	ACSL6 ARHGAP23 DLG4 AGAP7P AGAP4 AGAP6	4.34e-05	430	52	6	32581705
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 RYR3	4.58e-05	7	52	2	11860456
Pubmed	Association of multi-drug resistance gene polymorphisms with pancreatic cancer outcome.	ABCC3 ABCC1	4.58e-05	7	52	2	20922799
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR1 RYR3	4.58e-05	7	52	2	20962236
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 RYR3	6.10e-05	8	52	2	19033399
Pubmed	A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.	SMG1 PRKDC	6.10e-05	8	52	2	20810650
Pubmed	Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors.	RYR1 RYR3	6.10e-05	8	52	2	21441923
Pubmed	Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.	ABCC3 ABCC1	6.10e-05	8	52	2	15802388
Pubmed	ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.	RYR1 RYR3	6.10e-05	8	52	2	30563862
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR1 RYR3	6.10e-05	8	52	2	11784029
Pubmed	Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy.	RYR1 RYR3	7.84e-05	9	52	2	21858002
Pubmed	Tel2 regulates the stability of PI3K-related protein kinases.	SMG1 PRKDC	9.79e-05	10	52	2	18160036
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	SMG1 PRKDC	1.20e-04	11	52	2	20427287
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	DLG4 ITGA2 SSTR5 RYR3	1.27e-04	171	52	4	20201926
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	RYR1 RYR3	1.43e-04	12	52	2	19095005
Pubmed	Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.	PPP2R5C PRKDC	1.43e-04	12	52	2	16541024
Pubmed	Low BACH2 Expression Predicts Adverse Outcome in Chronic Lymphocytic Leukaemia.	SART3 PSAP CTNNBL1	1.61e-04	70	52	3	35008187
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	ABCC3 ABCC1 TMEM94 ITGA2 SLC26A6 SLC4A2	2.01e-04	569	52	6	30639242
Pubmed	The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome.	SART3 PSAP	2.60e-04	16	52	2	23022198
Pubmed	Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.	SMG1 FLT1	2.94e-04	17	52	2	10428027
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	DLG4 AGAP7P AGAP4 AGAP6	3.21e-04	218	52	4	33378226
Pubmed	Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.	SMG1 ABCC1 NAE1	3.60e-04	92	52	3	10493829
Pubmed	USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID.	CTNNBL1 PRKDC	5.93e-04	24	52	2	34983926
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	SMG1 ABCC3 ABCC1 ATP7A TMEM94 TRAPPC8	6.93e-04	719	52	6	35337019
Pubmed	DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.	DLG4 MDGA1	6.96e-04	26	52	2	34848499
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ABCC1 POGLUT3 TBC1D31 TMEM94 SLC26A6 SLC4A2	7.67e-04	733	52	6	34672954
Pubmed	Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.	A2M OTOG	8.08e-04	28	52	2	22808246
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DLG4 AGAP7P AGAP4 AGAP6	8.32e-04	281	52	4	28706196
Pubmed	AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.	SMG1 PRKDC	8.67e-04	29	52	2	20371770
Pubmed	Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.	POGLUT3 PSAP	8.67e-04	29	52	2	12652657
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR3	1.36e-05	3	39	2	287
GeneFamily	ArfGAPs	AGAP7P AGAP4 AGAP6	4.84e-05	33	39	3	395
GeneFamily	ATP binding cassette subfamily C	ABCC3 ABCC1	3.48e-04	13	39	2	807
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP4 AGAP6	6.04e-04	17	39	2	1291
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGAP23 AGAP7P AGAP4 AGAP6	9.85e-04	206	39	4	682
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_DN	TSPAN12 AGAP7P AGAP4 AGAP6	1.76e-06	44	52	4	MM485
ToppCell	Caecum-(1)_T_cell-(18)_cycling_gd_T\|Caecum / shred on region, Cell_type, and subtype	ABCC3 PIK3R6 ATP10B ITGA2 RYR1	3.45e-06	198	52	5	64278d8831c81874937e76b561c53928dfc437c5
ToppCell	Caecum-T_cell-cycling_gd_T\|Caecum / Region, Cell class and subclass	ABCC3 PIK3R6 ATP10B ITGA2 RYR1	3.45e-06	198	52	5	5b719b67f8384863077070e1eb7e04a320e6dab4
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PIK3R6 DISP1 RYR1 RYR3	2.16e-05	140	52	4	7cc891d676555609add6fc7880735d948a2ad801
ToppCell	Children_(3_yrs)-Immune-mast_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PIK3R6 ERP27 CTNNBL1 RYR3	3.07e-05	153	52	4	d3fb83ca984c7583b1e51c364be6c7c17f67b048
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	SMG1 ABCC1 KMT2C PPP2R5C	3.31e-05	156	52	4	1545169694f686d28648a68b552c2ae606599d66
ToppCell	Control-Mast_cells\|Control / group, cell type (main and fine annotations)	A2M PIK3R6 CTNNBL1 RYR3	4.52e-05	169	52	4	fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell	Control-Mast_cells-Mast_cells\|Control / group, cell type (main and fine annotations)	A2M PIK3R6 CTNNBL1 RYR3	4.62e-05	170	52	4	c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell	FF-Differ-KC\|World / shred by cell class for mouse tongue	TSPAN12 FLT1 SPIRE1 RYR1	5.65e-05	179	52	4	1526a130565a97c291a25a7a988089bffc1515c1
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M FLT1 PIK3R6 ITGA2	5.90e-05	181	52	4	9bfd93cf053beaee806cacdffd7abef02f94aec6
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M RYR3 OTOG DNAH1	6.29e-05	184	52	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M RYR3 OTOG DNAH1	6.29e-05	184	52	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M RYR3 OTOG DNAH1	6.29e-05	184	52	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	343B-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TBC1D31 CGRRF1 SLC4A2 METTL6	6.29e-05	184	52	4	2c2125b8030af83f7a6d59a7102d4de8e0ac1988
ToppCell	Endothelial-A-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	A2M FLT1 ARHGAP23 RYR3	6.42e-05	185	52	4	ae49c61f6ecf128fe2a958b8c75c83688da75f59
ToppCell	Control-Epithelial-Basal\|Epithelial / Disease state, Lineage and Cell class	ABCC3 ABCC1 ARHGAP23 ITGA2	6.42e-05	185	52	4	d5d6d13e2f20b54ca55645b9a757b8599f4fd897
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M FLT1 PIK3R6 ITGA2	6.69e-05	187	52	4	0ef82111b9049cc7ee78d64d240e1f10ab14d6b6
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M FLT1 PIK3R6 ITGA2	6.69e-05	187	52	4	25efb82afe863a853ecdd781ad89026c993aaa67
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TSPAN12 ABCC3 ERP27 ARHGAP23	6.83e-05	188	52	4	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TSPAN12 ABCC3 ERP27 ARHGAP23	6.83e-05	188	52	4	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	LAM-Myeloid-DC\|LAM / Condition, Lineage and Cell class	A2M ACSL6 PIK3R6 CYRIB	6.83e-05	188	52	4	b4140110c2f7d25fd8a0d2749e33e02003ac4bf2
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M FLT1 PIK3R6 ITGA2	6.98e-05	189	52	4	9e58411e51019ca59e78d3e737d65d2bcbbea2be
ToppCell	PCW_05-06-Endothelial-Endothelial_cycling-endo_proliferating1_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	A2M FLT1 PIK3R6 ITGA2	7.12e-05	190	52	4	9a2244c3973aee7270646bf00db7727edb9decc5
ToppCell	IPF-Epithelial-Basal\|Epithelial / Disease state, Lineage and Cell class	ABCC3 ABCC1 ARHGAP23 ITGA2	7.12e-05	190	52	4	4f15842b424eefadbfe451875e517cf70e29607f
ToppCell	droplet-Tongue-nan-3m-Epithelial-filiform\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPAN12 FLT1 SPIRE1 RYR1	7.12e-05	190	52	4	251e3a33041023bfc4b547c7eb68cfb8f421636f
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-filiform\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPAN12 FLT1 SPIRE1 RYR1	7.12e-05	190	52	4	8a53f4d3c9aca45b5826f53f7dcdfb8bc8280acb
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M FLT1 PIK3R6 ITGA2	7.41e-05	192	52	4	1f35efb0765e05f7f9c881849953bef3965be25a
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M FLT1 PIK3R6 ITGA2	8.19e-05	197	52	4	98e34e8612f111bb667a574de1faaa785d318ca4
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TSPAN12 KMT2C PRKDC RYR3	8.51e-05	199	52	4	a900ef002e1ae583b70be0253d8c44dae6754916
ToppCell	PSB-critical-LOC-Epithelial-Basal\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ABCC3 ARHGAP23 ITGA2 RYR1	8.51e-05	199	52	4	2add64c3e4cb6384ec381f34c3f1f77e13e3f27c
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	A2M TSPAN12 FLT1 DISP1	8.68e-05	200	52	4	3767abc75176779198505ebc6967d55ce322d9fe
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_capillary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	A2M TSPAN12 FLT1 DISP1	8.68e-05	200	52	4	5ab588808c1fc384019413401ab4bf9bc06bf529
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	A2M TSPAN12 FLT1 DISP1	8.68e-05	200	52	4	e0a003d2a5fd6adfcb817c9bc5dceb9c79e7491b
ToppCell	10x5'v1-week_14-16-Endothelial-stroma-tip_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	A2M TSPAN12 FLT1 ITGA2	8.68e-05	200	52	4	77ac1aa73c16a4f595ff01c6b4e171e0b8fed1e6
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Basal_3\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	ABCC3 ARHGAP23 ITGA2 RYR1	8.68e-05	200	52	4	06b59ee536414d1f73c1e17cdfd7c3f2259b9bef
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr-Polydendrocyte.Tnr.Opalin_(Opalin)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ERP27 ATP10B ITGA2	1.21e-04	82	52	3	5cd8e47edb775eabf3e9a407c1c2d8a78afb9509
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ERP27 ATP10B ITGA2	1.21e-04	82	52	3	1eeb259ec555879ee1962b7bc2c31c200fbb85cf
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Hpgd\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MDGA1 RYR1 RYR3	4.29e-04	126	52	3	9b04ca8a46cc30119baf6ef27711a0b2a6b4a0c9
ToppCell	Substantia_nigra-Macroglia-ASTROCYTE\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	A2M PSAP ITGA2	5.13e-04	134	52	3	a632d78890fcc20db81d2cf6b299470706d2e182
ToppCell	Substantia_nigra-Macroglia-ASTROCYTE-Gja1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	A2M PSAP ITGA2	5.13e-04	134	52	3	8be2db71d9d29f9a57a64efdc89cf8c3e32b363b
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	SEC61A2 TMEM94 ITGA2	5.13e-04	134	52	3	9e12aac8f42790c2f104dfd61c87aa99fc7925f1
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_C1ql2_Cdh13\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DISP1 RYR1 RYR3	5.36e-04	136	52	3	1f3000d5f105c87c80f8ae1dd2264bcd7f757a9c
ToppCell	MS-CD4-CD4_Treg\|MS / Condition, Cell_class and T cell subcluster	ARHGAP23 CATSPER3 OTOG	5.95e-04	141	52	3	df257dd4dcc45c1ace57340798e150a6e932531d
ToppCell	BLOOD--(0)_NK_cell-(0)_NK_cells_(CD56dim-like)\|(0)_NK_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PPP2R5C PSAP CYRIB	6.45e-04	145	52	3	6dd81d53d006fcc206a10969374a11c372f92133
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M SMG1 PPP2R5C	6.72e-04	147	52	3	22c9605869dd2e789896cd2790ee8def2605de57
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M SMG1 PPP2R5C	6.72e-04	147	52	3	ac272595818d25c6b84b107555b3351e912a01a7
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PSAP SPIRE1 CYRIB	6.85e-04	148	52	3	3f48f5ba0a0928ddf6da7a1be1976933921f42ad
ToppCell	droplet-Fat-Scat-21m-Myeloid-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSAP CYRIB RYR1	7.26e-04	151	52	3	79827a76c675dcb82f59c0a45d0f962b02d5bfd6
ToppCell	PND14-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PSAP CYRIB RYR1	7.40e-04	152	52	3	b2e29fbda6b5f2d87cfc05423caf9cbf3b04ac65
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ERP27 CUL7 MDGA1	7.40e-04	152	52	3	669d8f12fdb110ed72f4e5348b7b5350144a061c
ToppCell	PBMC-Control-cDC_8\|Control / Compartment, Disease Groups and Clusters	ARHGAP23 TP53INP2 SLC26A6	7.54e-04	153	52	3	db1a6914f2033fb0748e0523cffe5d6dc4e901be
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CGRRF1 TMEM94 RYR3	7.69e-04	154	52	3	16fdafb5c64d2db321554f87129a962d113f1668
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TMEM94 NAE1 AGAP6	7.83e-04	155	52	3	5687416773809b8c478567bc54310af102b3029a
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SEC61A2 OR10A6 SLC26A6	7.98e-04	156	52	3	abea3c183d32062b009a79a2bdf861021989c7ef
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-plasmacytoid_dendritic_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ERP27 SPIRE1 CUL7	8.13e-04	157	52	3	ffb8dd381e6b9adc5283fb49586e8bd63773c8d6
ToppCell	356C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ACSL6 ITGA2 DISP1	8.13e-04	157	52	3	f6210be2362d833c6d869ff921188bfc85dda11d
ToppCell	367C-Lymphocytic-ILC\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FLT1 PIK3R6 SPIRE1	8.13e-04	157	52	3	f511871e1a004c6e9af08ee325ab1bfc41807487
ToppCell	356C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ACSL6 ITGA2 DISP1	8.13e-04	157	52	3	43a6b423fd70479822a564ff4225a1e4951ae5ed
ToppCell	Children_(3_yrs)-Immune-mast_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PIK3R6 CTNNBL1 RYR3	8.13e-04	157	52	3	ec185dbeabb67fd9ca85f71cab88463b60f9b1c1
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ERP27 SPIRE1 CUL7	8.13e-04	157	52	3	c488ab1d6c6c7e5c2f4426805d1366b44711a031
ToppCell	droplet-Fat-Scat-21m-Myeloid-myeloid_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSAP CYRIB RYR1	8.28e-04	158	52	3	718eafcf8a171bb69b402dc9d69564c3521a62a9
ToppCell	droplet-Fat-Scat-21m-Myeloid\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSAP CYRIB RYR1	8.28e-04	158	52	3	c8df636412a08c570f235c34d4cff46924a9b11d
ToppCell	10x5'-bone_marrow-Mast\|bone_marrow / Manually curated celltypes from each tissue	TSPAN12 PIK3R6 RYR3	8.43e-04	159	52	3	c3d3570e83c5d25cc92fa3a7a8f0dc2f89a72913
ToppCell	10x5'-bone_marrow-Mast-Mast_cells\|bone_marrow / Manually curated celltypes from each tissue	TSPAN12 PIK3R6 RYR3	8.74e-04	161	52	3	15ba7e69699558353cfeecdcf1dbc2e147379ed6
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_4\|356C / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 SPIRE1 SLC26A6	8.90e-04	162	52	3	7d43d59531cbefe3ac94953b7faf7156b2a31441
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC1 ATP7A SPIRE1	9.06e-04	163	52	3	8dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCell	mild-Myeloid-Eosinophils\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ABCC1 PIK3R6 RYR3	9.06e-04	163	52	3	7c57d541a88e9afa079e95b8a6ecdea60a0c6aaa
ToppCell	356C-Lymphocytic-ILC-ILC-3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SPIRE1 TP53INP2 RYR1	9.06e-04	163	52	3	2dbdcbc4c187aad3db837d191cc78662a75dd0b5
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC1 ATP7A SPIRE1	9.06e-04	163	52	3	fd243ca223079033be480a24817a399f281fa4d4
ToppCell	Control-APC-like-Monocytes\|Control / group, cell type (main and fine annotations)	TBC1D31 MDGA1 ADAT1	9.06e-04	163	52	3	4bc80a2c741d462724b6f3902377d48c57478932
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic-Mast_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC1 PIK3R6 RYR3	9.22e-04	164	52	3	2c48c6e4eeee845f0563982d0bfa2a176ca5ef61
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	A2M PIK3R6 RYR3	9.38e-04	165	52	3	37615622c736e43260c38016e7c9e565ac97a3e8
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	A2M PIK3R6 RYR3	9.38e-04	165	52	3	640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCell	nucseq-Immune-Hematopoietic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	A2M PIK3R6 RYR3	9.38e-04	165	52	3	f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M PPP2R5C MDGA1	9.55e-04	166	52	3	9e916fc1858573358e1eb5e3789b2c9f8ef74476
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231\|Adult / Lineage, Cell type, age group and donor	FLT1 ARHGAP23 DISP1	9.71e-04	167	52	3	5af9127bae05768a5164d5708a4ad37edca99324
ToppCell	Children_(3_yrs)-Immune-enucleated_erythrocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FLT1 TP53INP2 RYR3	9.88e-04	168	52	3	8f0c4dfad9f6fed9dcc31795abfe77758ceb46a1
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	A2M ADAT1 RYR3	1.01e-03	169	52	3	16c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCell	ASK428-Endothelial-Endothelium\|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq	A2M FLT1	1.04e-03	41	52	2	a72d926de3dc9e420b80764af88002e436517790
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC1 PIK3R6 RYR1	1.06e-03	172	52	3	3a37569a5902f3c65ff8d3912421309a8c82ee9b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC1 PIK3R6 RYR1	1.06e-03	172	52	3	cc9d9dae290f11f8c348c78228af4e49469dc93b
ToppCell	E12.5-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FLT1 PIK3R6 ITGA2	1.06e-03	172	52	3	ba99688e9f46671deccf824b1e77c6db0742d7df
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|metastatic_Lymph_Node / Location, Cell class and cell subclass	A2M DISP1 DNAH1	1.06e-03	172	52	3	f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCell	E12.5-Endothelial-proliferative_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FLT1 PIK3R6 ITGA2	1.06e-03	172	52	3	2136170f6e1204734cec7dbf7b32e7d5179b92b5
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M FLT1 ARHGAP23	1.08e-03	173	52	3	3877cead288ce9509e6cccf57e55ec5e1bd7ce18
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIK3R6 CTNNBL1 OR10A6	1.09e-03	174	52	3	d77fa525d5c87c190b4a10787b270eabd16c610f
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M ATP7A ARHGAP23	1.11e-03	175	52	3	12f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCell	droplet-Mammary_Gland-nan-21m-Endothelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPAN12 FLT1 MDGA1	1.13e-03	176	52	3	27e5115fae5f0f63b333bc99fbf6a6d4c9182c46
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-nan\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM94 ITGA2 SLC4A2	1.13e-03	176	52	3	1dd54bfaa58541de51e5a8328651d390833bd480
ToppCell	AT1_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	ARHGAP23 ITGA2 MDGA1	1.13e-03	176	52	3	458720776b0151cd55acc352d509599cb62f0ca8
ToppCell	10x5'v1-week_14-16-Myeloid_macrophage-stroma-monocytoid_macrophage\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	A2M ABCC3 PSAP	1.15e-03	177	52	3	945b2d0723a0a35c767604ae607d2c2d53bf0c82
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	SART3 KMT2C CUL7	1.15e-03	177	52	3	eb0cfe8e9a91910f9979608ed47add48d98ce4dd
ToppCell	COPD-Epithelial-Basal\|Epithelial / Disease state, Lineage and Cell class	ABCC3 ABCC1 ITGA2	1.17e-03	178	52	3	441d1dba720141891b11f404744c59834d80e6c5
ToppCell	metastatic_Brain-T/NK_cells-Exhausted_Tfh\|T/NK_cells / Location, Cell class and cell subclass	ITGA2 AGAP4 AGAP6	1.17e-03	178	52	3	9a3581a0158dfa5a1cc942f8c532afb5e38b272a
ToppCell	390C-Endothelial_cells-Endothelial-E-\|390C / Donor, Lineage, Cell class and subclass (all cells)	TSPAN12 FLT1 ITGA2	1.17e-03	178	52	3	804ac3725c1f88e2212172bfb9aa01d97a735621
ToppCell	343B-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|343B / Donor, Lineage, Cell class and subclass (all cells)	TBC1D31 CGRRF1 METTL6	1.17e-03	178	52	3	5289ac61637224ae70ffbc2d164d73116f10af40
ToppCell	390C-Endothelial_cells-Endothelial-E\|390C / Donor, Lineage, Cell class and subclass (all cells)	TSPAN12 FLT1 ITGA2	1.17e-03	178	52	3	ad6dc4a375664c919bd48c35c48a561fc5a7de8c
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|368C / Donor, Lineage, Cell class and subclass (all cells)	SART3 KMT2C CUL7	1.17e-03	178	52	3	536a601abcc60867949ea06e9aafb6c7b799b56b
ToppCell	normal_Pleural_Fluid-Myeloid_cells-mo-Mac\|normal_Pleural_Fluid / Location, Cell class and cell subclass	A2M PSAP SPIRE1	1.19e-03	179	52	3	cd3c58e044f5a38e815313a1636153d81a592fce
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_4\|343B / Donor, Lineage, Cell class and subclass (all cells)	CTNNBL1 CUL7 RYR1	1.19e-03	179	52	3	c09c3eed43d1aa3b7aa8f3021e6f2737840cde16
ToppCell	BAL-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	SEC61A2 ATP7A SLC26A6	1.19e-03	179	52	3	68511e87b12b8253de7771e5ccfc5869248b8450
Drug	Kn 04	DLG4 ITGA2 RYR1 RYR3	3.48e-07	26	52	4	CID000131117
Drug	CHEBI:564108	ITGA2 RYR1 RYR3	3.91e-07	7	52	3	CID006400637
Drug	lactosyl lysosphingolipid	PSAP RYR1 RYR3	9.35e-07	9	52	3	CID006439268
Drug	platinum	TSPAN12 ABCC3 ABCC1 ATP7A ZNF875 ITGA2	3.72e-06	183	52	6	CID000023939
Drug	5'-adenylyl (beta,gamma-methylene)diphosphonate	RYR1 RYR3	5.12e-06	2	52	2	ctd:C005147
Drug	Apa-sg	ABCC3 ABCC1 PRKDC	1.06e-05	19	52	3	CID000126348
Drug	2-hydroxycarbazole	RYR1 RYR3	1.53e-05	3	52	2	CID000093551
Drug	1,1'-diheptyl-4,4'-bipyridinium	RYR1 RYR3	1.53e-05	3	52	2	CID000080262
Drug	cis-diammineplatinum(II	RYR1 RYR3	1.53e-05	3	52	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR1 RYR3	1.53e-05	3	52	2	CID002750949
Drug	flubendiamide	RYR1 RYR3	1.53e-05	3	52	2	CID011193251
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR3	1.53e-05	3	52	2	CID005748312
Drug	8N3-cADPR	RYR1 RYR3	1.53e-05	3	52	2	CID000127713
Drug	aminodantrolene	RYR1 RYR3	1.53e-05	3	52	2	CID009570289
Drug	5-carboxyfluorescein diacetate	ABCC3 ABCC1	1.53e-05	3	52	2	ctd:C084577
Drug	A-30	RYR1 RYR3	3.06e-05	4	52	2	CID003028528
Drug	PCB74	RYR1 RYR3	3.06e-05	4	52	2	CID000036218
Drug	148504-47-6	RYR1 RYR3	3.06e-05	4	52	2	CID006444275
Drug	Bastadin 10	RYR1 RYR3	3.06e-05	4	52	2	CID009589366
Drug	SC 38249	RYR1 RYR3	3.06e-05	4	52	2	CID000134834
Drug	AC1L1U7A	RYR1 RYR3	3.06e-05	4	52	2	CID000035682
Drug	grepafloxacin glucuronide	ABCC3 ABCC1	3.06e-05	4	52	2	CID000443296
Drug	Thioridazine hydrochloride [130-61-0]; Up 200; 9.8uM; MCF7; HT_HG-U133A	A2M ABCC3 FLT1 OR1G1 ATP10B	5.19e-05	177	52	5	4164_UP
Drug	prinomastat	A2M FLT1 PRKDC	5.84e-05	33	52	3	CID000466151
Drug	H2DIDS	ITGA2 SLC26A6 SLC4A2	5.84e-05	33	52	3	CID000115184
Drug	ruthenium	ITGA2 SSTR5 RYR1 RYR3	6.34e-05	94	52	4	CID000023950
Drug	AC1LAHTK	ABCC3 ABCC1	7.63e-05	6	52	2	CID000468713
Drug	AC1NB6SN	ABCC3 ABCC1	7.63e-05	6	52	2	CID004488324
Drug	MBED	RYR1 RYR3	7.63e-05	6	52	2	CID000129958
Drug	chloro-m-cresol	RYR1 RYR3	7.63e-05	6	52	2	CID000012008
Drug	AC1O528X	RYR1 RYR3	7.63e-05	6	52	2	CID006475857
Drug	NSC114784	RYR1 RYR3	7.63e-05	6	52	2	CID000419425
Drug	NSC692750	RYR1 RYR3	7.63e-05	6	52	2	CID000078910
Drug	Azumoleno	RYR1 RYR3	1.07e-04	7	52	2	CID000056259
Drug	mag-indo-1	RYR1 RYR3	1.07e-04	7	52	2	CID000131881
Drug	Br2BAPTA	RYR1 RYR3	1.07e-04	7	52	2	CID003081001
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR1 RYR3	1.07e-04	7	52	2	CID009547999
Drug	calcein AM	ABCC3 ABCC1	1.42e-04	8	52	2	ctd:C085925
Drug	nicotine glucuronide	ABCC3 ABCC1	1.42e-04	8	52	2	CID003035848
Drug	lanreotide	FLT1 SSTR5	1.42e-04	8	52	2	ctd:C060347
Drug	4,4'-dithiodipyridine	A2M RYR1 RYR3	1.49e-04	45	52	3	CID000075846
Drug	axitinib	FLT1 ATP7A PRKDC	1.49e-04	45	52	3	CID006450551
Drug	fluo-3	ABCC3 ABCC1 RYR1 RYR3	1.74e-04	122	52	4	CID000104978
Drug	1,3,5-triethylbenzene	ITGA2 RYR1	1.82e-04	9	52	2	CID000007602
Drug	FLA 365	RYR1 RYR3	1.82e-04	9	52	2	CID000072776
Drug	etridiazole	A2M RYR1 RYR3	2.04e-04	50	52	3	CID000017432
Drug	1y2g	ABCC3 ABCC1 FLT1 SLC4A2	2.16e-04	129	52	4	CID005287936
Drug	mercury	A2M ABCC3 ABCC1 ITGA2 RYR1 RYR3 DNAH1	2.20e-04	542	52	7	CID000023931
Drug	arpromidine	TSPAN12 ITGA2	2.28e-04	10	52	2	CID000065895
Drug	AC1N38XE	RYR1 RYR3	2.28e-04	10	52	2	CID004060965
Drug	AC1NN9F1	ABCC3 ABCC1	2.28e-04	10	52	2	CID000000410
Drug	PCB 95	RYR1 RYR3	2.28e-04	10	52	2	CID000038012
Drug	AC1L1IZE	ADAT1 RYR1 RYR3 DNAH1	2.29e-04	131	52	4	CID000004799
Drug	CsCl	CATSPER3 ITGA2 RYR1 RYR3	2.64e-04	136	52	4	CID000024293
Drug	PCB 66	RYR1 RYR3	2.78e-04	11	52	2	CID000036185
Drug	R 478	RYR1 RYR3	2.78e-04	11	52	2	CID000084223
Drug	8-amino-cADPR	RYR1 RYR3	2.78e-04	11	52	2	CID003081323
Drug	BAPNA	A2M RYR1 RYR3	3.01e-04	57	52	3	CID000013494
Drug	Ryanodine	RYR1 RYR3	3.33e-04	12	52	2	ctd:D012433
Disease	cerebral palsy (implicated_via_orthology)	AGAP7P AGAP4 AGAP6	6.14e-07	10	52	3	DOID:1969 (implicated_via_orthology)
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR3	9.13e-06	3	52	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR3	9.13e-06	3	52	2	DOID:8545 (implicated_via_orthology)
Disease	Papillary Renal Cell Carcinoma	FLT1 CUL7 RYR1	1.51e-03	128	52	3	C1306837
Disease	Renal Cell Carcinoma	FLT1 CUL7 RYR1	1.51e-03	128	52	3	C0007134
Disease	Sarcomatoid Renal Cell Carcinoma	FLT1 CUL7 RYR1	1.51e-03	128	52	3	C1266043
Disease	Chromophobe Renal Cell Carcinoma	FLT1 CUL7 RYR1	1.51e-03	128	52	3	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	FLT1 CUL7 RYR1	1.51e-03	128	52	3	C1266044

Protein segments in the cluster

Peptide	Gene	Start	Entry
YLTMTIISVTLEIPH	AGAP4	136	Q96P64
PIAILIMVLVDYSIE	SLC4A2	941	P04920
YEIVHVLSLMLEDLP	CATSPER3	371	Q86XQ3
VVATMPDLYHLLVEL	CTNNBL1	126	Q8WYA6
VITEPIYPEVVHMFA	PPP2R5C	86	Q13362
LMDTVYPAIAIVIVL	DISP1	501	Q96F81
EVFHREITMLPLAIV	ATP10B	111	O94823
YMVLVPSLLHTETTE	A2M	31	P01023
LMHLLEEPIYLSAVV	ADAT1	316	Q9BUB4
YLTMTIISVTLEIPH	AGAP6	136	Q5VW22
ATIVYQPHLISVEEM	ATP7A	211	Q04656
IYVVDEVLAPVILML	ABCC3	1076	O15438
VQYLDEPMLTVHQTV	MDGA1	126	Q8NFP4
IEKHTMVIEYIGTII	KMT2C	4791	Q8NEZ4
YAVPVTVMEPHTESL	CUL7	1646	Q14999
PYVHLVSITVMVILF	GDPD4	106	Q6W3E5
EIYVIEDNTVTIPLM	ITGA2	1106	P17301
VDVVMLIFVLSAVHP	METTL6	151	Q8TCB7
ILVIITDTQLHTPMY	OR1G1	46	P47890
AHFTEPLVEATIMVY	DNAH1	2406	Q9P2D7
YLTMTIISVTLEIPH	AGAP7P	136	Q5VUJ5
VTQMEVHYARPIIIL	DLG4	526	P78352
VIHLMLPETREIYEL	MALSU1	176	Q96EH3
LHMVTEYNPVTVIGL	ERP27	141	Q96DN0
VMVGVIILYDHVHPV	CYRIB	256	Q9NUQ9
EIYDIISMVSVIHIP	CGRRF1	186	Q99675
ISMVSVIHIPDRTYK	CGRRF1	191	Q99675
YPEHVCEVLLTMERT	SART3	541	Q15020
ARYTEMPHVIEITLP	RYR1	3261	P21817
IVIVSLDQSLHVPMY	OR10A6	46	Q8NH74
YILSQSPDEMLTVHV	OTOG	2136	Q6ZRI0
THSMSYLPQVDVIIV	ABCC1	826	P33527
VVIRQVYHLMETTPT	TBC1D31	641	Q96DN5
EDPVHVVVYIIFMLG	SEC61A2	356	Q9H9S3
LLLVVVRTQMPHYSV	SLC26A6	501	Q9BXS9
HVIIPLLHTVMYVLT	PIK3R6	71	Q5UE93
VLIDMTTGEVVHIDY	SMG1	2341	Q96Q15
TVMSVDRYLAVVHPL	SSTR5	131	P35346
MPYTDVVIHEIQRLV	CYP2G1P	1	Q6ZSU1
PLAHMFERVIQSVVY	ACSL6	321	Q9UKU0
VVLPTYDITHSMLEA	POGLUT3	271	Q7Z4H8
LEDLLIEHPSMSVYV	TP53INP2	96	Q8IXH6
VQSVMLHYAVPVVLA	TMEM94	276	Q12767
GARYTEMPHVIEVIL	RYR3	3121	Q15413
YPVECLALTVEEVMH	SPIRE1	551	Q08AE8
VTHMPDRYKIVETLI	ARHGAP23	1076	Q9P227
AEYEPVLIEILVEVM	PSAP	456	P07602
ILTYFPVVHPVMIAV	TSPAN12	56	O95859
YTPVLEHLVVMQIDS	PRKDC	431	P78527
GIHYMVVEIVATILS	PRKDC	2181	P78527
IITEEMPLLEVFFIH	TRAPPC8	906	Q9Y2L5
VMLETYNHLVSLEIP	ZNF875	61	P10072
VEMYSEIPEIIHMTE	FLT1	136	P17948
YMRIIIKEHPVIESH	NAE1	161	Q13564