Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhyaluronan synthase activity

HAS2 HAS3

4.09e-064172GO:0050501
GeneOntologyMolecularFunctionUDP-glycosyltransferase activity

MGAT2 HAS2 HAS3

2.77e-04153173GO:0008194
GeneOntologyMolecularFunctionlaminin binding

ACHE CTSS

3.77e-0434172GO:0043236
GeneOntologyMolecularFunctionhexosyltransferase activity

MGAT2 HAS2 HAS3

7.09e-04211173GO:0016758
GeneOntologyMolecularFunctionextracellular matrix binding

ACHE CTSS

1.73e-0373172GO:0050840
GeneOntologyMolecularFunctionglycosyltransferase activity

MGAT2 HAS2 HAS3

1.74e-03288173GO:0016757
GeneOntologyMolecularFunctioncollagen binding

ACHE CTSS

2.12e-0381172GO:0005518
GeneOntologyMolecularFunctionchromatin DNA binding

GRHL2 GRHL1

8.71e-03167172GO:0031490
GeneOntologyMolecularFunctionserine hydrolase activity

ACHE CTSS

1.37e-02212172GO:0017171
GeneOntologyBiologicalProcessglycosaminoglycan biosynthetic process

HAS2 HAS3 DSEL

3.15e-0576173GO:0006024
GeneOntologyBiologicalProcessaminoglycan biosynthetic process

HAS2 HAS3 DSEL

3.67e-0580173GO:0006023
GeneOntologyBiologicalProcessmucopolysaccharide metabolic process

HAS2 HAS3 DSEL

7.16e-05100173GO:1903510
GeneOntologyBiologicalProcesshyaluronan biosynthetic process

HAS2 HAS3

7.62e-0516172GO:0030213
GeneOntologyBiologicalProcessglycosaminoglycan metabolic process

HAS2 HAS3 DSEL

1.26e-04121173GO:0030203
GeneOntologyBiologicalProcesscarbohydrate metabolic process

MGAT2 HAS2 AKR7A2 HAS3 LCTL

1.34e-04646175GO:0005975
GeneOntologyBiologicalProcessaminoglycan metabolic process

HAS2 HAS3 DSEL

1.63e-04132173GO:0006022
GeneOntologyBiologicalProcessRNA 5'-end processing

CMTR2 ABT1

4.42e-0438172GO:0000966
GeneOntologyBiologicalProcesshyaluronan metabolic process

HAS2 HAS3

4.90e-0440172GO:0030212
DomainHAS/NodC

HAS2 HAS3

2.63e-063182IPR026107
DomainCP2

GRHL2 GRHL1

1.31e-056182IPR007604
DomainCP2

GRHL2 GRHL1

1.31e-056182PF04516
Domain-

MGAT2 HAS2 HAS3

6.12e-05811833.90.550.10
DomainNucleotide-diphossugar_trans

MGAT2 HAS2 HAS3

7.84e-0588183IPR029044
DomainGlyco_trans_2-like

HAS2 HAS3

3.76e-0430182IPR001173
DomainGlycos_transf_2

HAS2 HAS3

3.76e-0430182PF00535
PathwayREACTOME_HYALURONAN_BIOSYNTHESIS_AND_EXPORT

HAS2 HAS3

7.84e-065132MM14865
PathwayREACTOME_HYALURONAN_BIOSYNTHESIS_AND_EXPORT

HAS2 HAS3

7.84e-065132M27144
PathwayREACTOME_HYALURONAN_METABOLISM

HAS2 HAS3

1.06e-0417132M666
PathwayREACTOME_HYALURONAN_METABOLISM

HAS2 HAS3

1.06e-0417132MM14864
PathwayREACTOME_GLYCOSAMINOGLYCAN_METABOLISM

HAS2 HAS3 DSEL

1.74e-04123133MM14623
PathwayREACTOME_GLYCOSAMINOGLYCAN_METABOLISM

HAS2 HAS3 DSEL

1.87e-04126133M695
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

HAS2 HAS3 DSEL

1.74e-03271133MM15406
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

HAS2 HAS3 DSEL

2.07e-03288133M16864
Pubmed

The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination.

HAS2 HAS3

2.53e-07218220507985
Pubmed

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.

GRHL2 GRHL1

2.53e-07218229309642
Pubmed

Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties.

HAS2 HAS3

7.59e-07318210455188
Pubmed

Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells.

HAS2 HAS3

7.59e-07318216564133
Pubmed

Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family.

HAS2 HAS3

7.59e-0731829442026
Pubmed

Roles of Grainyhead-like transcription factors in cancer.

GRHL2 GRHL1

7.59e-07318228714958
Pubmed

Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis.

GRHL2 GRHL1

7.59e-07318224375798
Pubmed

Mammalian hyaluronan synthases: investigation of functional relationships in vivo.

HAS2 HAS3

7.59e-07318210093717
Pubmed

Analysis of hyaluronic acid in the endometrium of women with polycystic ovary syndrome.

HAS2 HAS3

7.59e-07318230614308
Pubmed

The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors.

GRHL2 GRHL1

7.59e-07318212549979
Pubmed

Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space.

HAS2 HAS3

7.59e-07318224790187
Pubmed

Inhibition of hyaluronan synthases decreases matrix metalloproteinase-7 (MMP-7) expression and activity.

HAS2 HAS3

7.59e-07318219231585
Pubmed

Hyaluronan expressed by the hematopoietic microenvironment is required for bone marrow hematopoiesis.

HAS2 HAS3

7.59e-07318222654110
Pubmed

Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells.

HAS2 HAS3

7.59e-07318211790779
Pubmed

An in situ hybridization study of Hyaluronan synthase (Has) mRNA in developing mouse molar and incisor tooth germs.

HAS2 HAS3

7.59e-07318227289075
Pubmed

In vitro synthesis of hyaluronan by a single protein derived from mouse HAS1 gene and characterization of amino acid residues essential for the activity.

HAS2 HAS3

7.59e-07318210617644
Pubmed

Perturbation of hyaluronan synthesis in the trabecular meshwork and the effects on outflow facility.

HAS2 HAS3

7.59e-07318222695958
Pubmed

Three vertebrate hyaluronan synthases are expressed during mouse development in distinct spatial and temporal patterns.

HAS2 HAS3

7.59e-07318215765504
Pubmed

Oxidized low density lipoprotein (LDL) affects hyaluronan synthesis in human aortic smooth muscle cells.

HAS2 HAS3

7.59e-07318223979132
Pubmed

Spatial and temporal expression of the Grainyhead-like transcription factor family during murine development.

GRHL2 GRHL1

7.59e-07318216831572
Pubmed

Hyaluronan Modulates the Biomechanical Properties of the Cornea.

HAS2 HAS3

7.59e-07318236478198
Pubmed

Recent discoveries concerning the involvement of transcription factors from the Grainyhead-like family in cancer.

GRHL2 GRHL1

7.59e-07318226069269
Pubmed

Hyaluronan synthases.

HAS2 HAS3

7.59e-0731829206724
Pubmed

Expression regulation of hyaluronan synthase in corneal endothelial cells.

HAS2 HAS3

7.59e-07318211006212
Pubmed

Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes.

HAS2 HAS3

7.59e-07318224057227
Pubmed

Hyaluronan Regulates Eyelid and Meibomian Gland Morphogenesis.

HAS2 HAS3

7.59e-07318230046813
Pubmed

Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.

HAS2 HAS3

7.59e-07318211431361
Pubmed

TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate.

HAS2 HAS3

7.59e-07318216786194
Pubmed

Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3.

HAS2 HAS3

7.59e-07318225795779
Pubmed

Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.

HAS2 HAS3

7.59e-07318223303191
Pubmed

A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead.

GRHL2 GRHL1

7.59e-07318212175488
Pubmed

Hyaluronan Derived From the Limbus is a Key Regulator of Corneal Lymphangiogenesis.

HAS2 HAS3

7.59e-07318230897620
Pubmed

Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28.

GRHL2 GRHL1

7.59e-07318212393799
Pubmed

Hyaluronan in cervical epithelia protects against infection-mediated preterm birth.

HAS2 HAS3

1.52e-06418225384213
Pubmed

Dynamic states of cervical epithelia during pregnancy and epithelial barrier disruption.

HAS2 HAS3

1.52e-06418236718364
Pubmed

Hyaluronan Rich Microenvironment in the Limbal Stem Cell Niche Regulates Limbal Stem Cell Differentiation.

HAS2 HAS3

1.52e-06418228863216
Pubmed

Further evidence for the association of MMP9 with nephropathy in type 2 diabetes and application of DNA pooling technology to candidate gene screening.

HAS2 HAS3

1.52e-06418218587729
Pubmed

Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma.

HAS2 HAS3

1.52e-06418223560496
Pubmed

Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta.

HAS2 HAS3

1.52e-06418214636845
Pubmed

Putative hyaluronan synthase mRNA are expressed in mouse skin and TGF-beta upregulates their expression in cultured human skin cells.

HAS2 HAS3

1.52e-0641829457904
Pubmed

Nitric oxide alters hyaluronan deposition by airway smooth muscle cells.

HAS2 HAS3

1.52e-06418229966020
Pubmed

Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan.

GRHL2 GRHL1

1.52e-06418235013237
Pubmed

The control and importance of hyaluronan synthase expression in palatogenesis.

HAS2 HAS3

1.52e-06418223382716
Pubmed

Hyaluronan synthase induction and hyaluronan accumulation in mouse epidermis following skin injury.

HAS2 HAS3

1.52e-06418215854028
Pubmed

Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content.

HAS2 HAS3

2.53e-06518219435493
Pubmed

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma.

HAS2 HAS3

2.53e-06518220875124
Pubmed

A pericellular hyaluronan matrix is required for the morphological maturation of cortical neurons.

HAS2 HAS3

2.53e-06518232623025
Pubmed

FGF9 Promotes Expression of HAS2 in Palatal Elevation via the Wnt/β-Catenin/TCF7L2 Pathway.

HAS2 HAS3

3.79e-06618236358989
Pubmed

Grainyhead-like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety-like behaviors in aged mice.

GRHL2 GRHL1

5.30e-06718227907249
Pubmed

The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity.

GRHL2 GRHL1

9.09e-06918221081122
Pubmed

Chromosomal localization of the human and mouse hyaluronan synthase genes.

HAS2 HAS3

2.29e-05141829169154
Pubmed

The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors.

HAS2 HAS3

3.02e-051618233454424
Pubmed

The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex.

GRHL2 GRHL1

3.02e-051618220978075
Pubmed

Lung morphogenesis is orchestrated through Grainyhead-like 2 (Grhl2) transcriptional programs.

GRHL2 GRHL1

3.02e-051618230194919
Pubmed

A genetic approach to Mammalian glycan function.

MGAT2 HAS2

1.09e-043018212676797
Pubmed

An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart.

GRHL1 HAS2

1.49e-043518218832392
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

TRRAP ABT1 MGAT2 FADS3

4.40e-0471918435337019
InteractionHAS2 interactions

HAS2 HAS3

4.52e-064182int:HAS2
InteractionGRHL1 interactions

GRHL2 GRHL1

1.13e-056182int:GRHL1
InteractionGRHL3 interactions

GRHL2 GRHL1

3.38e-0510182int:GRHL3
InteractionHAS3 interactions

HAS2 HAS3

5.84e-0513182int:HAS3
InteractionCLOCK interactions

TRRAP ABT1 EIPR1

9.72e-05102183int:CLOCK
CytobandEnsembl 112 genes in cytogenetic band chr2p25

GRHL1 EIPR1

1.13e-03127182chr2p25
CytobandEnsembl 112 genes in cytogenetic band chr16q22

CMTR2 HAS3

2.32e-03183182chr16q22
CytobandEnsembl 112 genes in cytogenetic band chr7q22

TRRAP ACHE

3.30e-03219182chr7q22
GeneFamilyGlycosyltransferase family 2

HAS2 HAS3

5.04e-066112428
CoexpressionKONDO_EZH2_TARGETS

CMTR2 HAS2 HAS3 DSEL

1.58e-05229184M5301
CoexpressionBLANCO_MELO_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_A594_CELLS_UP

ACHE CTSS HAS3 DSEL

3.76e-05286184M34008
CoexpressionKOHN_EMT_EPITHELIAL

GRHL2 GRHL1

1.02e-0422182M46416
CoexpressionMEL18_DN.V1_UP

CTSS FADS3 HAS2

1.17e-04141183M2784
CoexpressionBMI1_DN.V1_UP

CTSS FADS3 HAS2

1.33e-04147183M2782
ToppCellCV-Mild-4|Mild / Virus stimulation, Condition and Cluster

CMTR2 FADS3 HAS3

3.46e-051601832e24f8de5086b086863d3bf4d9afbd9bc93f4d5e
ToppCellLPS-IL1RA-Epithelial_airway-Club_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRHL2 PTPRR GRHL1

3.80e-051651831a114eacaab598f755a173a3fed842ba91f689dd
ToppCellLPS-IL1RA-Epithelial_airway-Club_cells-Airway|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRHL2 PTPRR GRHL1

3.80e-051651839cfd3c1d2c6d714fde83b90465f1f9741b0e50ce
ToppCellLPS-antiTNF-Epithelial_airway-Club_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRHL2 PTPRR GRHL1

3.86e-051661831df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
ToppCellLPS-antiTNF-Epithelial_airway-Club_cells-Airway|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRHL2 PTPRR GRHL1

3.86e-051661839628522e7af8f8edca733588a364ab2454ac5ca5
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CTSS ABT1 MGAT2

4.00e-0516818327cdf5cfa1d906868cfd60fdfab3cd51f3b3602f
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GRHL2 PTPRR GRHL1

4.68e-05177183a4c001a8e44142babf9f24dfe6f7b73a70b11b16
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GRHL2 PTPRR GRHL1

4.68e-05177183363e07b0f347f3716d530a28ead854b98e27d37c
ToppCellEpithelial-basal_cell|World / Lineage, Cell type, age group and donor

GRHL2 PTPRR GRHL1

4.84e-05179183d9be6647ec7b22747dc00dce4ea307b6af412dfa
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-mLTo|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ACHE CTSS HAS2

4.92e-05180183f103e161e966c257eac97e1b30a461c4ed9cafc2
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRR ACHE HAS3

5.00e-051811837af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCellEpithelial-lung_goblet_cell|World / Lineage, Cell type, age group and donor

GRHL2 PTPRR GRHL1

5.16e-05183183940cbe298e9c53b5622af09264586ed823d3141f
ToppCellTCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma-6|TCGA-Skin / Sample_Type by Project: Shred V9

GRHL2 GRHL1 HAS3

5.51e-051871832ca7928baf0c5e61f7294ed05e6e6f0e0adf9d3f
ToppCellCOVID-19-lung-Secretory|lung / Disease (COVID-19 only), tissue and cell type

GRHL2 PTPRR GRHL1

5.68e-0518918384d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCellC_05|World / shred on cell type and cluster

PTPRR ACHE CTSS

6.33e-05196183bf4dfb460a153dbafb2b9b12b360c8757cec22cd
ToppCell11.5-Airway-Epithelial|Airway / Age, Tissue, Lineage and Cell class

GRHL2 GRHL1 HAS3

6.43e-05197183e671af1b69566d97afe97f1a959a07b6f4c05620
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

GRHL2 FADS3 DSEL

6.52e-05198183b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GRHL2 PTPRR GRHL1

6.52e-051981836ba5e5970109a04ed968bac7ff099ae250c579dc
ToppCellFetal_29-31_weeks-Epithelial-club_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GRHL2 PTPRR GRHL1

6.52e-051981835fc25b008a4d8d6bec83923a16f64dd9e1ff1f2d
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

GRHL2 FADS3 DSEL

6.62e-05199183a270630626df614f8605abddb7dee7c4d74f6149
ToppCellLPS_only-Epithelial_alveolar-AT_1-AT1|LPS_only / Treatment groups by lineage, cell group, cell type

GRHL2 FADS3 DSEL

6.62e-05199183ccdde5d4bcc72f230a1dd2544ee7f4dfb98a5e80
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

GRHL2 FADS3 DSEL

6.62e-051991831c70e7d6bd25980e1b92aa1cac3f3c95d9651b4b
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

GRHL2 FADS3 DSEL

6.72e-05200183ddfb1f006365bf16203ee49f20200f68220cc288
ToppCellLPS_only-Epithelial_alveolar-AT_1|LPS_only / Treatment groups by lineage, cell group, cell type

GRHL2 FADS3 DSEL

6.72e-052001839a6ae40f3e17cd44ee5fd73260713b920aa2ea15
Drugglucosiduronate

HAS2 AKR7A2 HAS3 DSEL

8.66e-06171184CID000000610
DrugMusk T

HAS2 HAS3

3.23e-0511182CID000061014
Drugacridine

ACHE HAS2 HAS3

3.41e-0581183CID000009215
DrugAC1NR9X9

ACHE CTSS

3.88e-0512182CID000657093
DrugNSC46155

HAS2 HAS3

3.88e-0512182CID000457869
Drugpentoxyresorufin

HAS2 AKR7A2 HAS3

4.22e-0587183CID000107683
DrugDCNB

HAS2 AKR7A2 HAS3

5.49e-0595183CID000007443
Drugpheophytin

GRHL2 ACHE HAS2 HAS3

6.32e-05284184CID000000250
Drug3-hydroxyandrostan-17-one

GRHL1 HAS2 HAS3

6.78e-05102183CID000000225
Drugethoxyquin

HAS2 AKR7A2 HAS3

9.94e-05116183CID000003293
DrugC x F

HAS2 HAS3

1.00e-0419182CID000013017
DrugT4-G

HAS2 HAS3

1.00e-0419182CID000152424
DrugAC1L9N3X

GRHL2 ACHE

1.23e-0421182CID000449421
Drug4-methylumbelliferone

HAS2 HAS3 LCTL

1.46e-04132183CID003364573
Drugoltipraz

HAS2 AKR7A2 HAS3

1.63e-04137183CID000047318
Druglycopene

ACHE CTSS MGAT2

1.85e-04143183ctd:C015329
Drugbutylated hydroxytoluene

HAS2 AKR7A2 HAS3

1.85e-04143183CID000031404
Drugacetol

CTSS AKR7A2

1.90e-0426182CID000008299
DrugL-idaro-1,4-lactone

HAS2 HAS3

2.20e-0428182CID000078997
Drug7-hydroxycoumarin glucuronide

HAS2 HAS3

2.37e-0429182CID000125641
Drugdisulfiram

HAS2 AKR7A2 HAS3

2.48e-04158183CID000003117
DrugBP-3,6-quinol

HAS2 HAS3

3.07e-0433182CID000119292
DrugAC1NOWCJ

HAS2 HAS3

3.46e-0435182CID005120112
Drug3-[(3S,5R,10S,13R,14S,17R)-3-[(2S,4R,5R,6S)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

HAS2 HAS3

3.46e-0435182CID010436171
Drugl-borneol

HAS2 HAS3

3.87e-0437182CID000010049
DrugSN-38

ACHE HAS2 HAS3

3.87e-04184183CID000104842
Drugpiracetam

ACHE CTSS

4.08e-0438182CID000004843
Drugharmol

HAS2 HAS3

4.52e-0440182CID000068094
Drug1,2-naphthoquinone

ACHE AKR7A2

4.52e-0440182CID000010667
Drugp-fluorophenylalanine

HAS2 HAS3

4.52e-0440182CID000004654
DrugScopolamin-N-oxide hydrobromide [6106-81-6]; Down 200; 10uM; PC3; HT_HG-U133A

ABT1 LRP5L FADS3

4.66e-041961836335_DN
Drugtetraethylenepentamine pentahydrochloride; Down 200; 100uM; HL60; HG-U133A

GRHL2 CTSS LRP5L

4.66e-04196183412_DN
DrugMetergoline [17692-51-2]; Down 200; 10uM; HL60; HG-U133A

TRRAP CTSS ABT1

4.66e-041961831606_DN
Drug2-butyl-6-methoxyphenol

HAS2 AKR7A2 HAS3

4.73e-04197183CID011954184
DrugMethiazole; Down 200; 15uM; MCF7; HT_HG-U133A

MGAT2 FADS3 AKR7A2

4.73e-041971834354_DN
Drug2-AF

HAS2 HAS3

4.75e-0441182CID000005800
DrugDosulepin hydrochloride [897-15-4]; Up 200; 12uM; MCF7; HT_HG-U133A

CTSS MGAT2 FADS3

4.87e-041991835986_UP
Drugbeta-naphthoflavone

HAS2 AKR7A2 HAS3

4.94e-04200183CID000002361
DrugUDP-N-acetylglucosamine

MGAT2 HAS2 HAS3

5.16e-04203183CID000001167
Drugandrosterone glucuronide

HAS2 HAS3

5.23e-0443182CID000114833
Drug7,8-benzoquinoline

HAS2 HAS3

5.23e-0443182CID000009191
DrugBacitracin

ACHE CTSS

5.48e-0444182ctd:D001414
DrugMS-222

HAS2 HAS3

5.48e-0444182CID000011400
DrugDL-1,2-anhydro-myo-inositol

TRRAP ACHE

5.99e-0446182CID000002859
DrugAcetylcarnitine

ACHE CTSS

6.52e-0448182ctd:D000108
Drugsalicylamide

HAS2 HAS3

6.52e-0448182CID000005147
Drughexadeca-10,12-dien-1-ol

GRHL2 GRHL1

6.79e-0449182CID000013850
Drugglyoxal

GRHL1 AKR7A2

6.79e-0449182CID000007860
Drugglutathione reduced

ACHE HAS2 AKR7A2 HAS3

7.05e-04534184CID000000745
DrugNeuromedin B

GRHL2 GRHL1

7.07e-0450182CID004345957
Drug5-hydroxyindole

ACHE GRHL1

7.07e-0450182CID000016054
Drugpropionaldehyde

GRHL1 AKR7A2

7.36e-0451182CID000000527
DrugPolyethylene Glycols

PTPRR ACHE HAS2

7.42e-04230183ctd:D011092
Druglimonene

ACHE MGAT2

7.65e-0452182ctd:C008281
DrugAC1NQGK1

HAS2 HAS3

7.65e-0452182CID005195977
DrugUDP - Na

MGAT2 HAS2 HAS3

7.90e-04235183CID000001158
Diseaseautosomal dominant nonsyndromic deafness (implicated_via_orthology)

TRRAP GRHL2

3.51e-072182DOID:0050564 (implicated_via_orthology)
Diseasepulmonary hypertension (biomarker_via_orthology)

HAS2 HAS3

1.08e-0380182DOID:6432 (biomarker_via_orthology)
Diseaseascending aortic diameter

PTPRR HAS2

3.25e-03140182EFO_0021787

Protein segments in the cluster

PeptideGeneStartEntry
AEFHRWSSYMVHWKN

ACHE

586

P22303
WAETYRNRFWKEHHF

AKR7A2

256

O43488
HYLKSHRFPCHWSWV

CMTR2

156

Q8IYT2
HYREAKFSQTKHHWW

MGAT2

221

Q10469
KFSQTKHHWWWKLHF

MGAT2

226

Q10469
AHAKAWHSYNTTWRS

LCTL

236

Q6UWM7
IYWTAWQHHSIKRVH

LRP5L

176

A4QPB2
HSHWVWNVRYNHSHD

EIPR1

271

Q53HC9
TQHVKHYWYTSWPDH

PTPRR

541

Q15256
DLWNLKYLHRFTWSH

ABT1

141

Q9ULW3
DEQLKYWKYWHSRQH

GRHL2

311

Q6ISB3
YWKYWHSRQHTAKQR

GRHL2

316

Q6ISB3
DQLRHWKYWHSRQHT

GRHL1

316

Q9NZI5
EWLYNAMWFHKHHLW

HAS2

361

Q92819
HHWHLWKKTYGKQYK

CTSS

26

P25774
LYNSLWFHKHHLWMT

HAS3

366

O00219
WFHKHHLWMTYESVV

HAS3

371

O00219
SAHWWNFRHFQHHAK

FADS3

211

Q9Y5Q0
DVWDAHYKMFWFDHH

DSEL

626

Q8IZU8
WHSKNLKKNWSHYSF

TAMM41

61

Q96BW9
SHWSSIFMWRQHHYQ

TRRAP

2986

Q9Y4A5