Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	activating signal cointegrator 1 complex	ASCC2 ASCC3	5.86e-05	3	93	2	GO:0099053
GeneOntologyCellularComponent	cytosolic ribosome	RPS4Y2 RPS4X RPS4Y1 ASCC2 ASCC3	2.32e-04	124	93	5	GO:0022626
Domain	RIBOSOMAL_S4E	RPS4Y2 RPS4X RPS4Y1	1.23e-07	3	94	3	PS00528
Domain	40S_S4_C	RPS4Y2 RPS4X RPS4Y1	1.23e-07	3	94	3	IPR032277
Domain	Ribosomal_S4e_N_CS	RPS4Y2 RPS4X RPS4Y1	1.23e-07	3	94	3	IPR018199
Domain	RS4NT	RPS4Y2 RPS4X RPS4Y1	1.23e-07	3	94	3	PF08071
Domain	Ribosomal_S4e_central_region	RPS4Y2 RPS4X RPS4Y1	1.23e-07	3	94	3	IPR013845
Domain	Ribosomal_S4e_N	RPS4Y2 RPS4X RPS4Y1	1.23e-07	3	94	3	IPR013843
Domain	Ribosomal_S4e_central	RPS4Y2 RPS4X RPS4Y1	1.23e-07	3	94	3	PD002667
Domain	Ribosomal_S4e	RPS4Y2 RPS4X RPS4Y1	1.23e-07	3	94	3	IPR000876
Domain	Ribosomal_S4e	RPS4Y2 RPS4X RPS4Y1	1.23e-07	3	94	3	PF00900
Domain	40S_S4_C	RPS4Y2 RPS4X RPS4Y1	1.23e-07	3	94	3	PF16121
Domain	ARM-type_fold	IPO5 HIP1 DOCK11 NBEAL2 TTI2 INTS1 NOC3L FRYL IPO4 TRRAP TBCD	1.08e-06	339	94	11	IPR016024
Domain	S4	RPS4Y2 RPS4X RPS4Y1	1.23e-06	5	94	3	PS50889
Domain	S4	RPS4Y2 RPS4X RPS4Y1	1.23e-06	5	94	3	SM00363
Domain	S4_RNA-bd	RPS4Y2 RPS4X RPS4Y1	2.44e-06	6	94	3	IPR002942
Domain	ARM-like	IPO5 NBEAL2 TTI2 NOC3L FRYL IPO4 TRRAP MED12 TBCD	8.79e-06	270	94	9	IPR011989
Domain	KOW	RPS4Y2 RPS4X RPS4Y1	1.98e-05	11	94	3	IPR005824
Domain	KOW	RPS4Y2 RPS4X RPS4Y1	1.98e-05	11	94	3	PF00467
Domain	EamA_dom	SLC35G5 SLC35G6 SLC35G4	4.32e-05	14	94	3	IPR000620
Domain	EamA	SLC35G5 SLC35G6 SLC35G4	4.32e-05	14	94	3	PF00892
Domain	Nucleoside_tran	SLC29A1 SLC29A4	1.49e-04	4	94	2	PF01733
Domain	S4	RPS4X RPS4Y1	1.49e-04	4	94	2	PF01479
Domain	Eqnu_transpt	SLC29A1 SLC29A4	1.49e-04	4	94	2	IPR002259
Domain	DEAD/DEAH_box_helicase_dom	DDX60 DDX60L ASCC3 DHX30	5.02e-04	73	94	4	IPR011545
Domain	DEAD	DDX60 DDX60L ASCC3 DHX30	5.02e-04	73	94	4	PF00270
Domain	-	IPO5 FRYL IPO4 TRRAP MED12 TBCD	8.99e-04	222	94	6	1.25.10.10
Domain	HEAT	IPO5 IPO4 TBCD	1.81e-03	48	94	3	PF02985
Domain	Helicase_C	DDX60 DDX60L ASCC3 DHX30	2.09e-03	107	94	4	PF00271
Domain	HELICc	DDX60 DDX60L ASCC3 DHX30	2.09e-03	107	94	4	SM00490
Domain	Helicase_C	DDX60 DDX60L ASCC3 DHX30	2.16e-03	108	94	4	IPR001650
Domain	IMPORTIN_B_NT	IPO5 IPO4	2.19e-03	14	94	2	PS50166
Domain	HELICASE_CTER	DDX60 DDX60L ASCC3 DHX30	2.24e-03	109	94	4	PS51194
Domain	HELICASE_ATP_BIND_1	DDX60 DDX60L ASCC3 DHX30	2.24e-03	109	94	4	PS51192
Domain	DEXDc	DDX60 DDX60L ASCC3 DHX30	2.24e-03	109	94	4	SM00487
Domain	Helicase_ATP-bd	DDX60 DDX60L ASCC3 DHX30	2.31e-03	110	94	4	IPR014001
Domain	LRR_6	TCTE1 AMN1 FBXL20	2.68e-03	55	94	3	PF13516
Domain	HEAT	IPO5 IPO4 TBCD	3.12e-03	58	94	3	IPR000357
Domain	Importin-beta_N	IPO5 IPO4	3.24e-03	17	94	2	IPR001494
Domain	Olfact_rcpt	OR52E8 OR52E6 OR4M1 OR4C13 OR2A5 OR4X2 OR52E2	3.69e-03	393	94	7	IPR000725
Domain	Leu-rich_rpt_Cys-con_subtyp	AMN1 FBXL20	4.05e-03	19	94	2	IPR006553
Domain	LRR_CC	AMN1 FBXL20	4.05e-03	19	94	2	SM00367
Domain	MFS_dom	SLC22A13 SLC29A1 MFSD5 SLC29A4	4.69e-03	134	94	4	IPR020846
Domain	HEAT_REPEAT	IPO5 IPO4 TBCD	5.30e-03	70	94	3	PS50077
Pathway	REACTOME_SARS_COV_2_MODULATES_HOST_TRANSLATION_MACHINERY	RPS4Y2 RPS4X RPS4Y1 GEMIN5	9.84e-05	51	67	4	M45019
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	IPO5 POLR1A RPS4X INTS1 NOC3L GEMIN5 SRP72 FRYL URB2 ASCC3 IPO4 TRRAP MED12 DHX30	3.42e-09	653	96	14	22586326
Pubmed	Inactivation of the Rps4 gene on the mouse X chromosome.	RPS4Y2 RPS4X RPS4Y1	2.04e-08	3	96	3	1783379
Pubmed	Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome.	RPS4Y2 RPS4X RPS4Y1	2.04e-08	3	96	3	2124517
Pubmed	Expression level of Rps4 mRNA in 39,X mice and 40,XX mice.	RPS4Y2 RPS4X RPS4Y1	2.04e-08	3	96	3	8187552
Pubmed	Relationship between the monosomy X phenotype and Y-linked ribosomal protein S4 (Rps4) in several species of mammals: a molecular evolutionary analysis of Rps4 homologs.	RPS4Y2 RPS4X RPS4Y1	2.04e-08	3	96	3	8808278
Pubmed	Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes.	RPS4Y2 RPS4X RPS4Y1	8.14e-08	4	96	3	8139551
Pubmed	RT-PCR of fatty acid elongases.	SLC35G5 SLC35G6 SLC35G4	8.14e-08	4	96	3	9056918
Pubmed	Emergence of primate genes by retrotransposon-mediated sequence transduction.	SLC35G5 SLC35G6 SLC35G4	8.14e-08	4	96	3	17101974
Pubmed	Use of a reverse transcriptase-polymerase chain reaction assay to analyze allele-specific expression in individual hippocampal neurons.	RPS4Y2 RPS4X RPS4Y1	2.03e-07	5	96	3	9562962
Pubmed	Maintenance of X inactivation of the Rps4, Zfx, and Ube1 genes in a mouse in vitro system.	RPS4Y2 RPS4X RPS4Y1	2.03e-07	5	96	3	7681608
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SIN3B TMEM161A HIP1 POLR1A PIEZO1 INTS1 NOC3L ASCC2 GEMIN5 SRP72 URB2 ASCC3 IPO4 ZBTB7B TRRAP MED12 DHX30	6.77e-07	1497	96	17	31527615
Pubmed	An evaluation of the inactive mouse X chromosome in somatic cell hybrids.	RPS4Y2 RPS4X RPS4Y1	7.08e-07	7	96	3	8460399
Pubmed	Embryonic growth and the evolution of the mammalian Y chromosome. II. Suppression of selfish Y-linked growth factors may explain escape from X-inactivation and rapid evolution of Sry.	RPS4Y2 RPS4X RPS4Y1	7.08e-07	7	96	3	7928394
Pubmed	Physical mapping of 2000 kb of the mouse X chromosome in the vicinity of the Xist locus.	RPS4Y2 RPS4X RPS4Y1	1.13e-06	8	96	3	8468051
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	IPO5 DDX60 GEMIN5 FRYL ASCC3 IPO4 DHX30	1.55e-06	202	96	7	33005030
Pubmed	Cloning and localization of the murine Xpct gene: evidence for complex rearrangements during the evolution of the region around the Xist gene.	RPS4Y2 RPS4X RPS4Y1	1.69e-06	9	96	3	9545634
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	POLR1A DOCK11 NOC3L ASCC2 GEMIN5 GFPT2 ASCC3 TRRAP DHX30	3.75e-06	440	96	9	34244565
Pubmed	Rps4 maps near the inactivation center on the mouse X chromosome.	RPS4Y2 RPS4X RPS4Y1	5.71e-06	13	96	3	1740345
Pubmed	XIST and the mapping of the X chromosome inactivation centre.	RPS4Y2 RPS4X RPS4Y1	5.71e-06	13	96	3	1772416
Pubmed	Cellular response to small molecules that selectively stall protein synthesis by the ribosome.	ASCC2 ASCC3	7.54e-06	2	96	2	30875366
Pubmed	The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations.	ASCC2 ASCC3	7.54e-06	2	96	2	33139697
Pubmed	Functional equivalence of human X- and Y-encoded isoforms of ribosomal protein S4 consistent with a role in Turner syndrome.	RPS4X RPS4Y1	7.54e-06	2	96	2	8358435
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	POLR1A DOCK11 NBEAL2 ASCC2 HERC1 ASCC3 TRRAP HYDIN MED12	9.98e-06	497	96	9	36774506
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HIP1 NBEAL2 PIEZO1 INTS1 GEMIN5 FRYL ATG9A HERC1 TRRAP MFSD5 MED12 TBCD DHX30	1.10e-05	1105	96	13	35748872
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	IPO5 SIN3B LOX INTS1 SRP72 ASCC3 IPO4	1.38e-05	282	96	7	23667531
Pubmed	Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome.	RPS4Y2 RPS4X RPS4Y1	2.25e-05	20	96	3	16635246
Pubmed	Epiregulin (EREG) is upregulated through an IL-1β autocrine loop in Caco-2 epithelial cells with reduced CFTR function.	EREG CFTR	2.26e-05	3	96	2	29091309
Pubmed	Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction.	RPS4Y2 RPS4Y1	2.26e-05	3	96	2	22708584
Pubmed	Nucleoside transporters are widely expressed in ovarian carcinoma effusions.	SLC29A1 SLC29A4	4.51e-05	4	96	2	21822668
Pubmed	Clustering of Genetic Anomalies of Cilia Outer Dynein Arm and Central Apparatus in Patients with Transposition of the Great Arteries.	DNAH9 HYDIN	4.51e-05	4	96	2	36140829
Pubmed	A spectrum of ABCC6 mutations is responsible for pseudoxanthoma elasticum.	CFTR ABCC6	4.51e-05	4	96	2	11536079
Pubmed	The ASC-1 Complex Disassembles Collided Ribosomes.	ASCC2 ASCC3	4.51e-05	4	96	2	32579943
Pubmed	Molecular evolution of the equilibrative nucleoside transporter family: identification of novel family members in prokaryotes and eukaryotes.	SLC29A1 SLC29A4	4.51e-05	4	96	2	12446811
Pubmed	Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells.	CFTR SLC29A1	4.51e-05	4	96	2	12820662
Pubmed	RNA ligase-like domain in activating signal cointegrator 1 complex subunit 1 (ASCC1) regulates ASCC complex function during alkylation damage.	ASCC2 ASCC3	4.51e-05	4	96	2	29997253
Pubmed	Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP/TAZ activation.	PIEZO1 TAFAZZIN	4.51e-05	4	96	2	34606042
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	TMEM201 RAB3GAP1 POLR1A TTI2 NOC3L SRP72 URB2 ASCC3 IPO4 CEP97 TBCD	5.89e-05	942	96	11	31073040
Pubmed	Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.	IPO5 IPO4	7.50e-05	5	96	2	27528606
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	TMEM201 RAB3GAP1 POLR1A RPS4X NOC3L GEMIN5 DDX60L URB2 ASCC3 IPO4 TRRAP MED12 DHX30	8.88e-05	1353	96	13	29467282
Pubmed	Defining the membrane proteome of NK cells.	IPO5 RPS4X RPS4Y1 NBEAL2 INTS1 GEMIN5 ATG9A ASCC3 IPO4 SLC29A1 MFSD5 MED12	9.06e-05	1168	96	12	19946888
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	IPO5 POLR1A RPS4X TTI2 INTS1 SRP72 TRRAP	1.07e-04	390	96	7	17643375
Pubmed	The little (lit) mutation cosegregates with the growth hormone releasing factor receptor on mouse chromosome 6.	GHRHR CFTR	1.12e-04	6	96	2	8268652
Pubmed	Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells.	ASCC2 ASCC3	1.12e-04	6	96	2	32099016
Pubmed	Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule.	RPS4Y2 RPS4X RPS4Y1	1.25e-04	35	96	3	15031101
Pubmed	A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.	ASCC2 ASCC3	1.57e-04	7	96	2	36302773
Pubmed	Disruption of Scube2 Impairs Endochondral Bone Formation.	SCUBE3 IHH	1.57e-04	7	96	2	25639508
Pubmed	Analysis of the sperm flagellar axoneme using gene-modified mice.	TCTE1 CFAP54	2.09e-04	8	96	2	32554934
Pubmed	Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.	IPO5 IPO4	2.09e-04	8	96	2	27114554
Pubmed	Novel transcription coactivator complex containing activating signal cointegrator 1.	ASCC2 ASCC3	2.09e-04	8	96	2	12077347
Pubmed	The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.	RPS4Y2 RPS4X LOX RPS4Y1	2.52e-04	110	96	4	18307411
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	IPO5 TMEM161A RAB3GAP1 HIP1 RPS4X SRP72 IPO4	2.53e-04	449	96	7	31732153
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	NOC3L SRP72 DDX60L URB2 ASCC3 DHX30	3.26e-04	332	96	6	25693804
Pubmed	PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.	IPO5 POLR1A RPS4X ASCC3 CEP97	3.48e-04	217	96	5	31685992
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR52E8 OR4M1 OR4C13 OR2A5 OR4X2 OR52E2	3.70e-04	340	96	6	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR52E8 OR4M1 OR4C13 OR2A5 OR4X2 OR52E2	3.70e-04	340	96	6	11802173
Pubmed	Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis.	RPS4Y2 RPS4X LOX RPS4Y1	3.73e-04	122	96	4	29530978
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR52E8 OR4M1 OR4C13 OR2A5 OR4X2 OR52E2	3.88e-04	343	96	6	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR52E8 OR4M1 OR4C13 OR2A5 OR4X2 OR52E2	4.06e-04	346	96	6	14611657
Pubmed	Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung.	HIP1 IHH	4.08e-04	11	96	2	12569124
Pubmed	Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS.	DDX60 ASCC2 SRP72 DDX60L ASCC3	4.36e-04	228	96	5	30471916
Pubmed	The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation.	RPS4Y2 RPS4X RPS4Y1	4.56e-04	54	96	3	18495661
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	IPO5 TMEM201 LOX DDR2 INTS1 NOC3L GEMIN5 URB2 SLC29A1 MED12 TBCD	4.87e-04	1203	96	11	29180619
Pubmed	BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma.	IPO5 IPO4	4.89e-04	12	96	2	29686263
Pubmed	MRG15 is a novel PALB2-interacting factor involved in homologous recombination.	SIN3B TRRAP	4.89e-04	12	96	2	19553677
Pubmed	Hedgehog signaling orchestrates cartilage-to-bone transition independently of Smoothened.	HIP1 IHH	4.89e-04	12	96	2	35472633
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	RPS4X DDX60 HERC1 SLC4A5 DHX30	4.91e-04	234	96	5	36243803
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	RPS4X RPS4Y1	5.77e-04	13	96	2	14660691
Pubmed	Contribution of adenosine related genes to the risk of depression with disturbed sleep.	SLC29A1 SLC29A4	5.77e-04	13	96	2	20392501
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	IPO5 RAB3GAP1 HIP1 DDX60 TTI2 NOC3L ASCC2 GEMIN5 SRP72 DDX60L ASCC3 IPO4	6.10e-04	1440	96	12	30833792
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	RAB3GAP1 POLR1A RPS4X URB2 ASCC3 IPO4 TRRAP DHX30	7.52e-04	704	96	8	29955894
Pubmed	Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues.	HIP1 IHH	7.73e-04	15	96	2	9502734
Pubmed	Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.	TRRAP MED12	7.73e-04	15	96	2	18418385
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	IPO5 POLR1A INTS1 NOC3L SRP72 TRRAP	8.00e-04	394	96	6	27248496
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	TMEM161A EREG URB2 ATG9A GFPT2 HERC1 TRRAP TBCD	8.61e-04	719	96	8	35337019
Pubmed	The collagen receptor, discoidin domain receptor 2, functions in Gli1-positive skeletal progenitors and chondrocytes to control bone development.	DDR2 IHH	8.82e-04	16	96	2	35140200
Pubmed	Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?	SIN3B PIWIL4	8.82e-04	16	96	2	16787967
Pubmed	Genetic interaction mapping in mammalian cells using CRISPR interference.	GEMIN5 TRRAP MED12	9.36e-04	69	96	3	28481362
Pubmed	Repression of rRNA transcription by PARIS contributes to Parkinson's disease.	RPS4Y2 RPS4Y1 NOC3L SRP72 DHX30	9.66e-04	272	96	5	25315684
Pubmed	Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.	RPS4Y2 RPS4X RPS4Y1	1.15e-03	74	96	3	29795351
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	DDX60 URB2 ATG9A HERC1 ASCC3	1.19e-03	285	96	5	32838362
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	POLR1A NOC3L SRP72 URB2 ASCC3 TRRAP MED12 DHX30	1.22e-03	759	96	8	35915203
Pubmed	FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification.	GFPT2 IPO4 MED12	1.33e-03	78	96	3	25720964
Pubmed	Structure of the human 80S ribosome.	RPS4Y2 RPS4X RPS4Y1	1.54e-03	82	96	3	25901680
Pubmed	Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.	RPS4Y2 RPS4X RPS4Y1	1.60e-03	83	96	3	19799774
Pubmed	Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.	POLR1A RPS4X URB2 ATG9A MED12 TAFAZZIN	1.65e-03	454	96	6	33226137
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	IPO5 NBEAL2 TTI2 IPO4	1.69e-03	183	96	4	23956138
Pubmed	A male germ-cell-specific ribosome controls male fertility.	RPS4Y2 RPS4X RPS4Y1	1.71e-03	85	96	3	36517592
Pubmed	MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.	SIN3B TRRAP	1.84e-03	23	96	2	20332121
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	IPO5 INTS1 ASCC3 TRRAP CEP97 HYDIN	1.94e-03	469	96	6	27634302
Pubmed	Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.	RPS4Y2 RPS4X RPS4Y1 DHX30	2.21e-03	197	96	4	32434143
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	POLR1A RPS4X NOC3L SRP72 URB2 DHX30	2.25e-03	483	96	6	36912080
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	IPO5 MMS22L TMEM161A TMEM201 RPS4X GEMIN5 ATG9A	2.32e-03	657	96	7	36180527
Pubmed	Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.	IPO5 IPO4	2.35e-03	26	96	2	23181366
Pubmed	Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development.	DDR2 CORIN	2.35e-03	26	96	2	21752929
Pubmed	Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning.	RPS4Y2 RPS4X RPS4Y1	2.42e-03	96	96	3	21529712
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	IPO5 TMEM201 POLR1A RPS4X INTS1 ASCC3 IPO4 MED12 TBCD DHX30	2.48e-03	1257	96	10	37317656
Pubmed	A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders.	RPS4X RPS4Y1	2.53e-03	27	96	2	11401437
Pubmed	Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.	HIP1 IHH	2.53e-03	27	96	2	15075292
Pubmed	Isolation of genes identified in mouse renal proximal tubule by comparing different gene expression profiles.	RPS4Y2 RPS4X RPS4Y1	2.56e-03	98	96	3	9507200
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	RPS4Y2 RPS4X RPS4Y1 SRP72 IPO4	2.70e-03	344	96	5	36282215
Interaction	SIRT7 interactions	IPO5 POLR1A RPS4X INTS1 NOC3L GEMIN5 SRP72 FRYL URB2 ASCC3 IPO4 TRRAP MED12 DHX30	2.99e-06	744	86	14	int:SIRT7
GeneFamily	Solute carriers	SLC9C1 SLC22A13 SLC35G5 SLC35G6 SLC4A5 SLC29A1 SLC29A4 SLC35G4	6.55e-05	395	63	8	752
GeneFamily	S ribosomal proteins	RPS4Y2 RPS4X RPS4Y1	2.23e-04	34	63	3	728
GeneFamily	Olfactory receptors, family 52	OR52E8 OR52E6 OR52E2	6.63e-04	49	63	3	165
GeneFamily	ATP binding cassette subfamily C	CFTR ABCC6	9.09e-04	13	63	2	807
GeneFamily	Armadillo repeat containing\|Importins	IPO5 IPO4	1.76e-03	18	63	2	596
Coexpression	TABULA_MURIS_SENIS_PANCREAS_PANCREATIC_STELLATE_CELL_AGEING	RPS4Y2 RPS4X RPS4Y1	3.81e-06	9	95	3	MM3821
Disease	Situs ambiguous	PKD1L1 DNAH9	3.12e-04	9	88	2	C1167664
Disease	Situs Inversus	PKD1L1 DNAH9	4.75e-04	11	88	2	C0037221
Disease	Situs ambiguus	PKD1L1 DNAH9	9.00e-04	15	88	2	C0266642
Disease	focal segmental glomerulosclerosis	OR4X2 IPO4	1.03e-03	16	88	2	EFO_0004236

Protein segments in the cluster

Peptide	Gene	Start	Entry
QVLPRLFGCLKISHL	URB2	326	Q14146
AHCAPVLLALRELLN	EXOC3L1	641	Q86VI1
HFVRQNLIVLPLLAL	CFAP54	2081	Q96N23
QIRILLFHGCPLITD	AMN1	221	Q8IY45
GLCLLFIVRTLLLHP	CFTR	126	P13569
EIFHIILNQICLLPI	ASCC2	321	Q9H1I8
LLCLLQLIHLPFLDN	DEPDC4	241	Q8N2C3
LFVVHCLLNRQVRLI	ADGRE4P	431	Q86SQ3
LHLLLCSICQPFFLI	CCDC144CP	1211	Q8IYA2
VKLRVLHCIFQLLLT	AADACL3	41	Q5VUY0
AIVLAAIFRCLHPLL	DHX30	886	Q7L2E3
LARHLLPCVIHAAVL	RAB3GAP1	776	Q15042
VQSLLEPLGLHCIFI	PADI1	616	Q9ULC6
RLVQLPCHTNIITIL	MSL3P1	121	P0C860
SILLILRLPFCGNHV	OR52E2	161	Q8NGJ4
VPLLTELCIQHIIRN	TCTE1	76	Q5JU00
VLPVRLELCLVLFFI	FFAR2	176	O15552
SCFLHVLGLLELLQP	INTS1	1906	Q8N201
RLKDPNIIHLLAVCI	DDR2	631	Q16832
LFRIIDCLLLPHAVL	MMS22L	966	Q6ZRQ5
IHRCALLILGVSPVI	HERC1	1446	Q15751
LHCLTVVFLLHLPLS	DDX60	311	Q8IY21
LRCLCVAFQLHLPLS	DDX60L	296	Q5H9U9
LVFLLLRLPFCGHRI	OR52E6	161	Q96RD3
GNILIICTIRLDPHL	OR4M1	41	Q8NGD0
QILLIFHLLFCGPNV	OR4X2	151	Q8NGF9
LPLHRCNIAVILLTD	FRYL	1591	O94915
LTCRILLHLFKTPQL	MED12	1171	Q93074
LVLALLLRLCRQPLH	GDPD2	101	Q9HCC8
FLHATIQILFICQLP	OR4C13	151	Q8NGP0
FEQLLPLIVNLICPH	IPO5	861	O00410
ANLLVFVVCFLPLHV	GPR35	221	Q9HC97
ALVHVVLILRLPFCG	OR2A5	156	Q96R48
LHNLIRILPINCFLK	FANCB	731	Q8NB91
VDRLCLLNRPLSLHL	RBBP8NL	286	Q8NC74
ICDLLLFQIILAPFH	DNAJC25	241	Q9H1X3
ALLITARCVVPALHL	HYDIN	686	Q4G0P3
LLQKEICPLIRIFIH	BPIFA2	211	Q96DR5
INILILLEVCLFHFR	DOCK11	1311	Q5JSL3
VIPLQLLSFHLAVLR	GFPT2	651	O94808
HIFLLICGLRQVKDP	GLT1D1	166	Q96MS3
LLRVLNLPHNSIGCV	CEP97	81	Q8IW35
VFCPEQLLRVILAHI	ATG9A	431	Q7Z3C6
ANLLRFLLLVLIPCI	CORIN	41	Q9Y5Q5
VAITILVALRRLHCP	GHRHR	146	Q02643
TVLLLGPLQLCALVH	LOX	6	P28300
VKPQLRPLLHVVCLI	DNAH9	331	Q9NYC9
PALLLCLGFHLLQAV	EREG	16	O14944
ALCSVRKIHLRPQVL	ESRG	56	Q1W209
LHLLLCSICQPFFLI	CCDC144A	1401	A2RUR9
RVVHLLPLLLACFVQ	GPX5	6	O75715
ACLTLNQHLLFRVIP	CAPN3	136	P20807
RHPQLRKVTLIIFCV	SLC22A13	326	Q9Y226
VPGLCLLVLLVHARA	SCUBE3	6	Q8IX30
HIRQRLLPPLLQIVC	IPO4	386	Q8TEX9
PQLVFLALSLIHLCV	PKD1L1	2526	Q8TDX9
FRVPLHSLACLGLLV	MFSD5	381	Q6N075
HFCLVLLLLLVVPAA	IHH	11	Q14623
FIKRLCTLALHVLPN	NOC3L	626	Q8WTT2
VFLLLRLPFCGHRII	OR52E8	166	Q6IFG1
QPFLSRLVLHILQDC	RTP5	111	Q14D33
NLPSLELLICRCLFH	SLC35G5	66	Q96KT7
ELLICRCLFHLPIAL	SLC35G5	71	Q96KT7
TCPRAVIHLLLCQLR	POLR1A	111	O95602
LVCLITLVVNRFILP	SLC9C1	406	Q4G0N8
VLCLLRLAVTRPHLQ	TMEM161A	321	Q9NX61
LHRINLTVPQGCLLA	ABCC6	646	O95255
TLIQLSIHCPRLQVL	FBXL20	316	Q96IG2
PILLLRLIHLFCAVL	NBEAL2	196	Q6ZNJ1
RLAPLIQVILDCSHL	HIP1	221	O00291
ILANRLCLPHLVALT	RHOBTB2	576	Q9BYZ6
QLAHLIPELCFLTGL	PIWIL4	371	Q7Z3Z4
LFVLHRVRLPTLKNC	SPPL2C	361	Q8IUH8
LCRAKQVQPLVLLRH	SIN3B	1081	O75182
HKLRECLPLIVFLRN	RPS4Y1	36	P22090
HKLRECLPLIVFLRN	RPS4Y2	36	Q8TD47
HKLRECLPLIIFLRN	RPS4X	36	P62701
EHLLPVLIQAAQLCR	SRP72	336	O76094
LARLVFVPLLLLCNI	SLC29A1	366	Q99808
AVCIINFQHLILPER	ASCC3	1281	Q8N3C0
ELVICRCLFHLPIAL	SLC35G4	71	P0C7Q5
CARLLTPHLLLVLVQ	SMOC1	6	Q9H4F8
LPDILIIHLKRFCQV	USP43	581	Q70EL4
VLQAARLLEIPCVIA	ZBTB7B	121	O15156
LPHLRSLINVCVNLV	UNC80	2631	Q8N2C7
IGRLIAECHLNPIIL	TAFAZZIN	166	Q16635
HLIQAVLLCLLDLFP	TTI2	306	Q6NXR4
LECCLVLLLIRSHFP	GEMIN5	1461	Q8TEQ6
VLLLIRSHFPGCLAQ	GEMIN5	1466	Q8TEQ6
RIHLFTLVQILCLAV	SLC4A5	1016	Q9BY07
FLLLLLEKCQIPRSH	SRRD	161	Q9UH36
PVQVILLRALAFLAC	TMEM201	211	Q5SNT2
NLPSLELLICRCLFH	SLC35G6	66	P0C7Q6
ELLICRCLFHLPIAL	SLC35G6	71	P0C7Q6
HLLACSCLRVVFIPL	SLC29A4	416	Q7RTT9
LQLCLLLCHRFPLIR	TBCD	1111	Q9BTW9
LVAHLALQICLHIVP	PIEZO1	71	Q92508
ALQICLHIVPRLDQL	PIEZO1	76	Q92508
ICLRIIIELHKQFRP	TRRAP	131	Q9Y4A5
LPCALVQLTLLFVHR	XK	46	P51811
LLHLLQLGPLFRCFE	XK	71	P51811
SRCLQLIVHYIPVIR	VPS54	811	Q9P1Q0