Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cell adhesion molecule binding	NPHS1 ROBO4 FLNB ABCF3 ADAM23 TNC ADAM20 L1CAM NLGN1 ITGA5 ITGAD ITGAX FASN PKP2 NLGN2 PLEC CD200R1L NOS3 CNTN1	7.23e-08	599	145	19	GO:0050839
GeneOntologyMolecularFunction	glucosidase activity	PGGHG SI MGAM2	1.60e-04	15	145	3	GO:0015926
GeneOntologyMolecularFunction	integrin binding	ADAM23 TNC ADAM20 L1CAM ITGA5 ITGAD ITGAX	2.95e-04	175	145	7	GO:0005178
GeneOntologyMolecularFunction	peptidase activity	USP34 SPG7 ERAP1 ADAM23 ADAM20 PSMB8 NCSTN DPP8 PRSS29P ATG4B AEBP1 ADAMTS9 LNPEP C1S	2.99e-04	654	145	14	GO:0008233
GeneOntologyMolecularFunction	endopeptidase activity	USP34 SPG7 ERAP1 ADAM23 ADAM20 PSMB8 NCSTN PRSS29P ATG4B ADAMTS9 C1S	3.11e-04	430	145	11	GO:0004175
GeneOntologyBiologicalProcess	oxoacid metabolic process	GLYAT ACO2 AS3MT GPAM CAV1 TST PTGIS ANKH ARG1 TXNRD1 ERFE FASN P4HTM ADSS2 OSBPL9 SESN2 SARDH DSEL NOS3 HTT	3.86e-05	1058	142	20	GO:0043436
GeneOntologyBiologicalProcess	organic acid metabolic process	GLYAT ACO2 AS3MT GPAM CAV1 TST PTGIS ANKH ARG1 TXNRD1 ERFE FASN P4HTM ADSS2 OSBPL9 SESN2 SARDH DSEL NOS3 HTT	4.18e-05	1064	142	20	GO:0006082
GeneOntologyBiologicalProcess	smooth muscle hyperplasia	HMOX1 NOS3	4.71e-05	2	142	2	GO:0014806
GeneOntologyBiologicalProcess	multicellular organismal-level iron ion homeostasis	HMOX1 TFR2 SLC11A1 HTT	6.67e-05	32	142	4	GO:0060586
GeneOntologyBiologicalProcess	cellular component maintenance	TPRN L1CAM NLGN1 CSMD2 PKP2 NLGN2	7.10e-05	101	142	6	GO:0043954
GeneOntologyBiologicalProcess	cell junction maintenance	L1CAM NLGN1 CSMD2 PKP2 NLGN2	8.54e-05	65	142	5	GO:0034331
GeneOntologyBiologicalProcess	carboxylic acid metabolic process	GLYAT ACO2 AS3MT GPAM CAV1 TST PTGIS ARG1 TXNRD1 ERFE FASN P4HTM ADSS2 OSBPL9 SESN2 SARDH DSEL NOS3 HTT	9.05e-05	1035	142	19	GO:0019752
GeneOntologyBiologicalProcess	heterotypic cell-cell adhesion	ITGA5 ITGAD ITGAX PKP2 CD200R1L	9.19e-05	66	142	5	GO:0034113
GeneOntologyBiologicalProcess	multicellular organismal-level homeostasis	PDGFRB DOCK11 KSR2 GPAM DLK1 NCSTN CAV1 ADGRV1 HMOX1 SIT1 ANKH TFR2 P4HTM SLC11A1 CLCN3 LNPEP NOS3 RCN3 HTT	1.00e-04	1043	142	19	GO:0048871
GeneOntologyBiologicalProcess	cell-cell adhesion	BOC NPHS1 RAG2 ROBO4 L1CAM PKD1L1 GPAM NLGN1 CAV1 ADGRV1 ITGA5 ITGAD ITGAX ARG1 NECTIN4 PKP2 NLGN2 CD200R1L CNTN1	1.52e-04	1077	142	19	GO:0098609
GeneOntologyCellularComponent	cell surface	BOC ROBO4 NID2 PDGFRB ADAM20 L1CAM MUC16 DLK1 NLGN1 CAV1 ADGRV1 ITGA5 ITGAD ITGAX TFR2 CLCN3 PTPRK ADAMTS9 LNPEP CSPG4 NLGN2 CD200R1L	8.40e-06	1111	145	22	GO:0009986
GeneOntologyCellularComponent	protein complex involved in cell adhesion	TNC NLGN1 ITGA5 ITGAD ITGAX	5.55e-05	59	145	5	GO:0098636
GeneOntologyCellularComponent	focal adhesion	NPHS1 FLNB PDGFRB TNC L1CAM SRCIN1 NCSTN CAV1 ITGA5 CSPG4 PLEC	2.15e-04	431	145	11	GO:0005925
GeneOntologyCellularComponent	cell-substrate junction	NPHS1 FLNB PDGFRB TNC L1CAM SRCIN1 NCSTN CAV1 ITGA5 CSPG4 PLEC	2.72e-04	443	145	11	GO:0030055
GeneOntologyCellularComponent	external side of plasma membrane	ROBO4 ADAM20 L1CAM MUC16 DLK1 NLGN1 ITGA5 ITGAD ITGAX TFR2 CLCN3 CD200R1L	2.75e-04	519	145	12	GO:0009897
GeneOntologyCellularComponent	anchoring junction	NPHS1 FLNB AOC1 PDGFRB TNC L1CAM SYNPO SRCIN1 NCSTN CAV1 ITGA5 PTPRK CSPG4 NECTIN4 PKP2 ANO7 PLEC	4.40e-04	976	145	17	GO:0070161
GeneOntologyCellularComponent	synaptic membrane	ADAM23 L1CAM NLGN1 NCSTN FXYD6P3 ITGA5 CSMD2 CLCN3 DGKI NLGN2 CNTN1 HTT	7.72e-04	583	145	12	GO:0097060
Domain	fn3	BOC NPHS1 ROBO4 TNC L1CAM PTPRK LRRN4 ANKFN1 CNTN1	4.40e-06	162	143	9	PF00041
Domain	FN3	BOC NPHS1 ROBO4 TNC L1CAM PTPRK LRRN4 ANKFN1 CNTN1	1.29e-05	185	143	9	SM00060
Domain	FN3	BOC NPHS1 ROBO4 TNC L1CAM PTPRK LRRN4 ANKFN1 CNTN1	2.30e-05	199	143	9	PS50853
Domain	FN3_dom	BOC NPHS1 ROBO4 TNC L1CAM PTPRK LRRN4 ANKFN1 CNTN1	3.38e-05	209	143	9	IPR003961
Domain	Integrin_alpha	ITGA5 ITGAD ITGAX	6.93e-05	11	143	3	PF00357
Domain	Integrin_alpha_C_CS	ITGA5 ITGAD ITGAX	2.29e-04	16	143	3	IPR018184
Domain	Integrin_alpha-2	ITGA5 ITGAD ITGAX	3.30e-04	18	143	3	IPR013649
Domain	INTEGRIN_ALPHA	ITGA5 ITGAD ITGAX	3.30e-04	18	143	3	PS00242
Domain	Integrin_alpha2	ITGA5 ITGAD ITGAX	3.30e-04	18	143	3	PF08441
Domain	Integrin_alpha	ITGA5 ITGAD ITGAX	3.30e-04	18	143	3	IPR000413
Domain	Gal_mutarotase_N	SI MGAM2	3.46e-04	4	143	2	IPR031727
Domain	NtCtMGAM_N	SI MGAM2	3.46e-04	4	143	2	PF16863
Domain	Int_alpha	ITGA5 ITGAD ITGAX	3.89e-04	19	143	3	SM00191
Domain	Int_alpha_beta-p	ITGA5 ITGAD ITGAX	3.89e-04	19	143	3	IPR013519
Domain	Nlgn	NLGN1 NLGN2	5.73e-04	5	143	2	IPR000460
Domain	-	BOC NPHS1 ROBO4 FLNB PDGFRB TNC L1CAM TRIM71 PTPRK NECTIN4 LRRN4 CD200R1L ANKFN1 CNTN1	5.76e-04	663	143	14	2.60.40.10
Domain	FG_GAP	ITGA5 ITGAD ITGAX	6.08e-04	22	143	3	PS51470
Domain	Ig_I-set	BOC NPHS1 ROBO4 PDGFRB L1CAM PTPRK CNTN1	6.59e-04	190	143	7	IPR013098
Domain	I-set	BOC NPHS1 ROBO4 PDGFRB L1CAM PTPRK CNTN1	6.59e-04	190	143	7	PF07679
Domain	FG-GAP	ITGA5 ITGAD ITGAX	7.91e-04	24	143	3	PF01839
Domain	FG-GAP	ITGA5 ITGAD ITGAX	7.91e-04	24	143	3	IPR013517
Domain	Glyco_hydro_31_AS	SI MGAM2	8.56e-04	6	143	2	IPR030458
Domain	Integrin_dom	ITGA5 ITGAD ITGAX	8.93e-04	25	143	3	IPR032695
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	USP34 ERAP1 L1CAM POMGNT1 DOLPP1 NCSTN CAV1 HMOX1 ITGA5 CERS5 P4HTM PTPRK LNPEP CSPG4 OSBPL9 TTC13 DSEL RCN3 HTT	6.65e-07	1201	145	19	35696571
Pubmed	Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth.	TNC L1CAM CNTN1	7.05e-07	5	145	3	12700241
Pubmed	Differential expression of phosphacan/RPTPbeta isoforms in the developing mouse visual system.	TNC L1CAM CNTN1	7.05e-07	5	145	3	17722031
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	USP34 NID2 FLNB VWA8 PDGFRB ERAP1 ACO2 POMGNT1 HMOX1 CERS5 FASN PTPRK AEBP1 LNPEP NT5DC2 CSPG4 OSBPL9 PLEC RCN3 SMAD4	2.73e-06	1451	145	20	30550785
Pubmed	Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.	TNC CAV1 HMOX1 PTGIS NOS3 SMAD4	2.85e-06	94	145	6	20346360
Pubmed	UPF2 is a critical regulator of liver development, function and regeneration.	HMGXB4 CLASRP FASN C1S	2.89e-06	24	145	4	20657840
Pubmed	Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.	FLNB PDGFRB TNC L1CAM NCSTN CAV1 ITGA5 CSPG4 PLEC	3.37e-06	285	145	9	21423176
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	AS3MT TM6SF2 PTGIS CLCN3 NT5DC2 PDCD11 DGKI MYO15A RCN3	5.53e-06	303	145	9	25056061
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	DMXL2 ERAP1 TPRN TTC14 SYNPO SRCIN1 NCSTN NSD3 ARG1 ADSS2 DGKI TRIM50 SMAD4	6.84e-06	689	145	13	36543142
Pubmed	Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure.	NPHS1 PDGFRB SYNPO	8.34e-06	10	145	3	22840396
Pubmed	ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis.	NPHS1 PDGFRB CSPG4 SMAD4	8.36e-06	31	145	4	36445780
Pubmed	NG2 glia are required for vessel network formation during embryonic development.	PDGFRB L1CAM CSPG4	1.14e-05	11	145	3	26651999
Pubmed	Large-scale identification of genes implicated in kidney glomerulus development and function.	NPHS1 PDGFRB SYNPO CSPG4	1.22e-05	34	145	4	16498405
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	NCSTN TST EML3 EXOC8 TXNRD1 KLC3 SMAD4	1.25e-05	183	145	7	31932471
Pubmed	Association of platelet-derived growth factor receptor β accumulation with increased oxidative stress and cellular injury in sestrin 2 silenced human glioblastoma cells.	PDGFRB SESN2	1.73e-05	2	145	2	21536039
Pubmed	Dystrophic muscle in mice chimeric for expression of alpha5 integrin.	TNC ITGA5	1.73e-05	2	145	2	9813102
Pubmed	Genetic analysis of CAV1 gene in hypertension and metabolic syndrome.	CAV1 NOS3	1.73e-05	2	145	2	16601841
Pubmed	Atg4b-dependent autophagic flux alleviates Huntington's disease progression.	ATG4B HTT	1.73e-05	2	145	2	23861892
Pubmed	Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase.	CAV1 FASN	1.73e-05	2	145	2	18635971
Pubmed	The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer.	CAV1 PTGIS	1.73e-05	2	145	2	20122998
Pubmed	Cytokine-Mediated Regulation of ARG1 in Macrophages and Its Impact on the Control of Salmonella enterica Serovar Typhimurium Infection.	ARG1 SLC11A1	1.73e-05	2	145	2	34359992
Pubmed	Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcome.	CAV1 FASN	1.73e-05	2	145	2	18802406
Pubmed	BMPR1B up-regulation via a miRNA binding site variation defines endometriosis susceptibility and CA125 levels.	MUC16 BMPR1B	1.73e-05	2	145	2	24339876
Pubmed	The adverse cardiopulmonary phenotype of caveolin-1 deficient mice is mediated by a dysfunctional endothelium.	CAV1 NOS3	1.73e-05	2	145	2	18417152
Pubmed	Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-L-arginine methyl ester and angiotensin II.	CAV1 NOS3	1.73e-05	2	145	2	20097717
Pubmed	TXNRD1 knockdown inhibits the proliferation of endothelial cells subjected to oscillatory shear stress via activation of the endothelial nitric oxide synthase/apoptosis pathway.	TXNRD1 NOS3	1.73e-05	2	145	2	36754152
Pubmed	Atheroprotective role of Caveolin-1 and eNOS in an innovative transplantation model is mainly mediated by local effects.	CAV1 NOS3	1.73e-05	2	145	2	27915034
Pubmed	Endothelial nitric oxide synthase deficiency causes collateral vessel rarefaction and impairs activation of a cell cycle gene network during arteriogenesis.	CSPG4 NOS3	1.73e-05	2	145	2	20431061
Pubmed	Mutation spectrum of genes associated with steroid-resistant nephrotic syndrome in Chinese children.	NPHS1 PLCE1	1.73e-05	2	145	2	28476686
Pubmed	Nitric oxide synthases are crucially involved in the development of the severe cardiomyopathy of caveolin-1 knockout mice.	CAV1 NOS3	1.73e-05	2	145	2	18951881
Pubmed	Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons.	NLGN1 NLGN2	1.73e-05	2	145	2	19889999
Pubmed	Preliminary computational modeling of nitric oxide synthase 3 interactions with caveolin-1: influence of exon 7 Glu298Asp polymorphism.	CAV1 NOS3	1.73e-05	2	145	2	18180853
Pubmed	Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence.	CAV1 TXNRD1	1.73e-05	2	145	2	19820694
Pubmed	Altered angiogenesis in caveolin-1 gene-deficient mice is restored by ablation of endothelial nitric oxide synthase.	CAV1 NOS3	1.73e-05	2	145	2	22322296
Pubmed	Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth.	TNC ITGA5	1.73e-05	2	145	2	9314546
Pubmed	Caveolae and caveolin-1 in human term villous trophoblast.	CAV1 NOS3	1.73e-05	2	145	2	12852865
Pubmed	Smad4 promotes diabetic nephropathy by modulating glycolysis and OXPHOS.	NOS3 SMAD4	1.73e-05	2	145	2	31916354
Pubmed	Atorvastatin prevents hypoxia-induced inhibition of endothelial nitric oxide synthase expression but does not affect heme oxygenase-1 in human microvascular endothelial cells.	HMOX1 NOS3	1.73e-05	2	145	2	16620829
Pubmed	eNOS and caveolin-1 gene polymorphisms interaction and intima media thickness: a proof of concept study in ESRD patients.	CAV1 NOS3	1.73e-05	2	145	2	21976276
Pubmed	Endostatin associates with integrin alpha5beta1 and caveolin-1, and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells.	CAV1 ITGA5	1.73e-05	2	145	2	12359771
Pubmed	Hereditary spastic paraplegias with autosomal dominant, recessive, X-linked, or maternal trait of inheritance.	SPG7 L1CAM	1.73e-05	2	145	2	22554690
Pubmed	Neurological abnormalities in caveolin-1 knock out mice.	CAV1 HTT	1.73e-05	2	145	2	16750274
Pubmed	Preconditioning with soluble guanylate cyclase activation prevents postischemic inflammation and reduces nitrate tolerance in heme oxygenase-1 knockout mice.	HMOX1 NOS3	1.73e-05	2	145	2	23771693
Pubmed	Loss of caveolin-1 expression in knock-in mouse model of Huntington's disease suppresses pathophysiology in vivo.	CAV1 HTT	1.73e-05	2	145	2	24021477
Pubmed	Caveolin-1-dependent tenascin C inclusion in extracellular vesicles is required to promote breast cancer cell malignancy.	TNC CAV1	1.73e-05	2	145	2	37929694
Pubmed	The interaction between F3 immunoglobulin domains and protein tyrosine phosphatases zeta/beta triggers bidirectional signalling between neurons and glial cells.	TNC CNTN1	1.73e-05	2	145	2	10103110
Pubmed	eNOS Activity in CAV1 Knockout Mouse Eyes.	CAV1 NOS3	1.73e-05	2	145	2	27228562
Pubmed	Moderate caveolin-1 downregulation prevents NADPH oxidase-dependent endothelial nitric oxide synthase uncoupling by angiotensin II in endothelial cells.	CAV1 NOS3	1.73e-05	2	145	2	21659644
Pubmed	Genetic variants in haem oxygenase-1 and endothelial nitric oxide synthase influence the extent and evolution of coronary artery atherosclerosis.	HMOX1 NOS3	1.73e-05	2	145	2	22123460
Pubmed	Influence of caveolin-1 and endothelial nitric oxide synthase on adventitial inflammation in aortic transplants.	CAV1 NOS3	1.73e-05	2	145	2	31790082
Pubmed	Changes in pericytic expression of NG2 and PDGFRB and vascular permeability in the sensory circumventricular organs of adult mouse by osmotic stimulation.	PDGFRB CSPG4	1.73e-05	2	145	2	23629811
Pubmed	Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb.	ITGAD ITGAX	1.73e-05	2	145	2	9598326
Pubmed	Oleanolic acid attenuates liver ischemia reperfusion injury by HO-1/Sesn2 signaling pathway.	HMOX1 SESN2	1.73e-05	2	145	2	27733322
Pubmed	Loss of caveolin-1 causes blood-retinal barrier breakdown, venous enlargement, and mural cell alteration.	CAV1 NOS3	1.73e-05	2	145	2	24326256
Pubmed	Genetic Deletion of the NOS3 Gene in CAV1-/- Mice Restores Aqueous Humor Outflow Function.	CAV1 NOS3	1.73e-05	2	145	2	28973370
Pubmed	Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1.	CAV1 NOS3	1.73e-05	2	145	2	8910295
Pubmed	Deletion of caveolin-1 protects against oxidative lung injury via up-regulation of heme oxygenase-1.	CAV1 HMOX1	1.73e-05	2	145	2	18323531
Pubmed	A noninhibitory mutant of the caveolin-1 scaffolding domain enhances eNOS-derived NO synthesis and vasodilation in mice.	CAV1 NOS3	1.73e-05	2	145	2	21804187
Pubmed	Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia.	HMOX1 NOS3	1.73e-05	2	145	2	32559798
Pubmed	Targeted mutation of Cav-1 alleviates the effect of endotoxin in the inhibition of ET-1-mediated eNOS activation in the liver.	CAV1 NOS3	1.73e-05	2	145	2	19730165
Pubmed	ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing.	ANGEL1 ANGEL2	1.73e-05	2	145	2	36180430
Pubmed	Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1-deficient mice.	CAV1 NOS3	1.73e-05	2	145	2	18178722
Pubmed	Molecular events are associated with resistance to vinblastine in bladder cancer.	CAV1 FASN	1.73e-05	2	145	2	26025399
Pubmed	Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons.	NLGN1 NLGN2	1.73e-05	2	145	2	10892652
Pubmed	The role of caveolin-1 and endothelial nitric oxide synthase polymorphisms in susceptibility to prostate cancer.	CAV1 NOS3	1.73e-05	2	145	2	33964050
Pubmed	Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression.	NPHS1 NSD3	1.73e-05	2	145	2	28228401
Pubmed	Diet-induced obesity increases melanoma progression: involvement of Cav-1 and FASN.	CAV1 FASN	1.73e-05	2	145	2	21387314
Pubmed	Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression.	CAV1 FASN	1.73e-05	2	145	2	17786030
Pubmed	The role of caveolin-1 in PCB77-induced eNOS phosphorylation in human-derived endothelial cells.	CAV1 NOS3	1.73e-05	2	145	2	17933968
Pubmed	Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1.	ERAP1 LNPEP	1.73e-05	2	145	2	20592285
Pubmed	Deciphering the binding of caveolin-1 to client protein endothelial nitric-oxide synthase (eNOS): scaffolding subdomain identification, interaction modeling, and biological significance.	CAV1 NOS3	1.73e-05	2	145	2	24648521
Pubmed	Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition.	CAV1 NOS3	1.73e-05	2	145	2	22323292
Pubmed	Retinoic acid promotes the development of Arg1-expressing dendritic cells for the regulation of T-cell differentiation.	RAG2 ARG1	1.73e-05	2	145	2	23322377
Pubmed	Effects of homocysteine on the levels of caveolin-1 and eNOS in caveolae of human coronary artery endothelial cells.	CAV1 NOS3	1.73e-05	2	145	2	16616146
Pubmed	NLGN1 and NLGN2 in the prefrontal cortex: their role in memory consolidation and strengthening.	NLGN1 NLGN2	1.73e-05	2	145	2	29278843
Pubmed	Reduced expression of prostacyclin synthase and nitric oxide synthase in subcutaneous arteries of type 2 diabetic patients.	PTGIS NOS3	1.73e-05	2	145	2	24225501
Pubmed	Association of eNOS and Cav-1 gene polymorphisms with susceptibility risk of large artery atherosclerotic stroke.	CAV1 NOS3	1.73e-05	2	145	2	28346478
Pubmed	Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncoupling.	ARG1 NOS3	1.73e-05	2	145	2	28153047
Pubmed	Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia.	NPHS1 SYNPO	1.73e-05	2	145	2	17255128
Pubmed	Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.	PDGFRB SESN2	1.73e-05	2	145	2	24046361
Pubmed	Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells.	CAV1 NOS3	1.73e-05	2	145	2	29563255
Pubmed	Colocalization prostacyclin (PGI2) synthase--caveolin-1 in endothelial cells and new roles for PGI2 in angiogenesis.	CAV1 PTGIS	1.73e-05	2	145	2	11339822
Pubmed	Carbon Monoxide Regulates Macrophage Differentiation and Polarization toward the M2 Phenotype through Upregulation of Heme Oxygenase 1.	HMOX1 ARG1	1.73e-05	2	145	2	34943953
Pubmed	Genetic analysis of caveolin-1 and eNOS genes in colorectal cancer.	CAV1 NOS3	1.73e-05	2	145	2	16820915
Pubmed	Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.	NID2 ACO2 SYNPO SRCIN1 PLEC CNTN1	1.93e-05	131	145	6	28634551
Pubmed	Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels.	ITGA5 ITGAD ITGAX	1.97e-05	13	145	3	20563599
Pubmed	The transcription factor Sry-related HMG box-4 (SOX4) is required for normal renal development in vivo.	NPHS1 PDGFRB CSPG4	1.97e-05	13	145	3	23559562
Pubmed	Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues.	ADAM23 L1CAM NCSTN CNTN1	2.87e-05	42	145	4	15146195
Pubmed	Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.	PDGFRB SYNPO CSPG4	3.82e-05	16	145	3	33253712
Pubmed	Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle.	NID2 TNC ITGA5	3.82e-05	16	145	3	15878328
Pubmed	Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development.	PDGFRB ITGA5 CSPG4	3.82e-05	16	145	3	26542011
Pubmed	Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development.	NPHS1 PDGFRB CSPG4 NOS3	4.50e-05	47	145	4	28527294
Pubmed	A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS.	RAG2 DLK1 CSPG4	4.62e-05	17	145	3	28634350
Pubmed	Developmental expression and subcellular distribution of synaptotagmin 11 in rat hippocampus.	NLGN1 NLGN2	5.16e-05	3	145	2	22960622
Pubmed	Caveolin-1-eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability.	CAV1 NOS3	5.16e-05	3	145	2	21624953
Pubmed	Dendrite complexity of sympathetic neurons is controlled during postnatal development by BMP signaling.	BMPR1B SMAD4	5.16e-05	3	145	2	24048844
Pubmed	Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury.	HMOX1 NOS3	5.16e-05	3	145	2	16877550
Pubmed	Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation.	CAV1 NOS3	5.16e-05	3	145	2	31154825
Pubmed	Tenascin-C in the cochlea of the developing mouse.	TNC L1CAM	5.16e-05	3	145	2	10102501
Pubmed	Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca2+ and NO signals.	CAV1 NOS3	5.16e-05	3	145	2	39178948
Interaction	FBXO2 interactions	BOC NID2 ADAM23 L1CAM NCSTN ADGRV1 ITGA5 PTPRK LNPEP CSPG4 TTC13 CNTN1 HTT	7.05e-06	411	142	13	int:FBXO2
GeneFamily	Fibronectin type III domain containing	BOC NPHS1 ROBO4 TNC L1CAM PTPRK LRRN4 ANKFN1 CNTN1	1.23e-07	160	92	9	555
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA5 ITGAD ITGAX	9.84e-05	18	92	3	1160
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	NPHS1 NECTIN4 CD200R1L	1.10e-03	40	92	3	592
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	BOC ROBO4 PDGFRB L1CAM CNTN1	1.39e-03	161	92	5	593
GeneFamily	Immunoglobulin like domain containing	BOC NPHS1 PDGFRB PTPRK CNTN1	3.06e-03	193	92	5	594
GeneFamily	Dyneins, axonemal	DNAH10 DNAI1	3.31e-03	17	92	2	536
GeneFamily	Aminopeptidases\|CD molecules	ERAP1 LNPEP	3.31e-03	17	92	2	104
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLCH1 PLCE1	4.14e-03	19	92	2	832
Coexpression	DESCARTES_FETAL_LIVER_STELLATE_CELLS	NID2 PDGFRB BCO1 BMPR1B FBXO24 CSPG4 NEURL1B DSEL	3.17e-06	160	145	8	M40233
Coexpression	CUI_TCF21_TARGETS_2_UP	BOC GLYAT GRWD1 SMCHD1 HMGXB4 NT5DC2 RHEBL1 TTL SESN2 NLGN2 PLCH1 RCN3	9.13e-06	455	145	12	MM1189
Coexpression	LINDGREN_BLADDER_CANCER_CLUSTER_2B	NID2 PDGFRB TNC SYNPO RGS11 CAV1 MOXD1 AEBP1 ADAMTS9 C1S NEURL1B	1.14e-05	389	145	11	M4995
Coexpression	MANNE_COVID19_ICU_VS_HEALTHY_DONOR_PLATELETS_DN	FLNB CPAMD8 VWA8 SYNPO DLK1 NLGN1 MLH3	3.03e-05	159	145	7	M38979
Coexpression	CUI_TCF21_TARGETS_2_UP	BOC GRWD1 SMCHD1 HMGXB4 NT5DC2 RHEBL1 TTL SESN2 NLGN2 PLCH1 RCN3	3.34e-05	437	145	11	M1610
Coexpression	MANNE_COVID19_COMBINED_COHORT_VS_HEALTHY_DONOR_PLATELETS_DN	FLNB CPAMD8 VWA8 ZC3H12B SYNPO DLK1 NLGN1 MLH3	3.67e-05	224	145	8	M38981
Coexpression	FAN_EMBRYONIC_CTX_BIG_GROUPS_BRAIN_ENDOTHELIAL	ROBO4 NID2 PDGFRB PSMB8 CAV1 ITGA5 AEBP1 CSPG4 MAP4K2 PLCE1	3.79e-05	365	145	10	M39018
Coexpression	HE_LIM_SUN_FETAL_LUNG_C0_LATE_MESOTHELIAL_CELL	FLNB DOCK11 ERAP1 TPRN PSMB8 TST PTGIS ANKH EML3 ITPK1 P4HTM PKP2 LRRN4 PLEC	3.82e-05	704	145	14	M45672
Coexpression	RUAN_RESPONSE_TO_TNF_TROGLITAZONE_DN	SELENBP1 GPAM TST FASN	6.36e-05	39	145	4	M1524
CoexpressionAtlas	kidney_adult_RenalCapsule_top-relative-expression-ranked_1000	BOC NID2 DOCK11 ERAP1 ADAM23 PSMB8 MUC16 CAV1 PTGIS SAMD9L AEBP1 LNPEP C1S LRRN4 DSEL RCN3 PLCE1	1.65e-05	778	141	17	gudmap_kidney_adult_RenalCapsule_1000
CoexpressionAtlas	kidney_adult_RenalCapsule_top-relative-expression-ranked_500	BOC ERAP1 PSMB8 MUC16 CAV1 SAMD9L AEBP1 C1S LRRN4 DSEL RCN3 PLCE1	1.85e-05	408	141	12	gudmap_kidney_adult_RenalCapsule_500
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BOC PDGFRB ITGA5 CSMD2 PTGIS AEBP1 DGKI C1S ANKFN1	1.10e-08	185	146	9	9faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BOC NID2 PDGFRB TM6SF2 TMEM132C MOXD1 AEBP1 C1S RCN3	1.52e-08	192	146	9	b9e4585bea280ca0ae159f0c6a2bf7b88a15a6e6
ToppCell	droplet-Bladder-Unstain-18m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM23 TNC CAV1 ITGA5 PTGIS FEM1B ADAMTS9 C1S RCN3	1.74e-08	195	146	9	841fde528ecb293e07b5e00e499d1e9f0b0dce14
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NPHS1 NID2 PDGFRB TNC SYNPO CAV1 AEBP1 C1S PLCE1	1.82e-08	196	146	9	545d2e4469924d333e3f655f559c899fa1260196
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-4-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NID2 PDGFRB TNC PTGIS MOXD1 AEBP1 C1S DSEL RCN3	2.16e-08	200	146	9	4dbe21cb63569f28c7017cda065ea5ee00d7254e
ToppCell	Parenchyma_COVID-19-Stromal-TX-Fibroblasts-4\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	NID2 PDGFRB TNC PTGIS MOXD1 AEBP1 C1S DSEL RCN3	2.16e-08	200	146	9	bde938e5a18844fb8cc1d1be5a086809f7e2b97d
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-4\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	NID2 PDGFRB TNC PTGIS MOXD1 AEBP1 C1S DSEL RCN3	2.16e-08	200	146	9	8256511b099c3eab8e33194f90c9ff354e7cfe8e
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 PTGIS BCO1 AEBP1 C1S LRRN4 RCN3 PLCE1	1.54e-07	181	146	8	330d4322f4c4373f706273c1f4e218b59051b7fd
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 PTGIS BCO1 AEBP1 C1S LRRN4 RCN3 PLCE1	1.54e-07	181	146	8	3f4d5d79c1286614514b0e8134079d6128a2a23e
ToppCell	NS-moderate-d_16-33-Lymphoid-NK\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NID2 PDGFRB TNC NLGN1 CAV1 AEBP1 C1S RCN3	1.61e-07	182	146	8	fb503f8ecd013f1f2161a5841572b57cfcddb6fa
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC SLC25A27 PDGFRB P4HTM AEBP1 LRRN4 ANKFN1 RCN3	1.68e-07	183	146	8	ebe369dc80c4fbf8f4dbe947147f8c47507ffb60
ToppCell	moderate-Lymphoid-NK\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	NID2 TNC NLGN1 CAV1 AEBP1 CSPG4 C1S RCN3	1.82e-07	185	146	8	4979a787acbc9b4ca8defe91cc79b674e51af1bf
ToppCell	droplet-Lung-LUNG-30m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELENBP1 PDGFRB PTGIS AEBP1 CSPG4 C1S RCN3 CNTN1	1.98e-07	187	146	8	976b74d081b7fba8620768613cc26f9262cd7b16
ToppCell	COPD-Epithelial-Mesothelial\|COPD / Disease state, Lineage and Cell class	SELENBP1 MUC16 NLGN1 CAV1 PTGIS AEBP1 ADAMTS9 C1S	2.15e-07	189	146	8	79bb2593ad5d17f94b17972884241f03a0f43770
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BOC PDGFRB PTGIS TMEM132C MOXD1 AEBP1 C1S NLGN2	2.15e-07	189	146	8	d531399749409d614adca13d181830c6e3287508
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D175\|Adult / Lineage, Cell type, age group and donor	BOC NID2 PDGFRB NLGN1 PTGIS AEBP1 C1S ANKFN1	2.24e-07	190	146	8	7dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BOC SELENBP1 PTGIS TMEM132C AEBP1 NT5DC2 C1S RCN3	2.33e-07	191	146	8	ce80f65bd24b1c4d2152bf45248449e7a1a97e56
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BOC NID2 PDGFRB NLGN1 PTGIS TMEM132C AEBP1 C1S	2.42e-07	192	146	8	e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDGFRB TM6SF2 PTGIS TMEM132C MOXD1 AEBP1 C1S RCN3	2.42e-07	192	146	8	c5f8e766453f87847b740d6988c524b3d0ef3765
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PDGFRB SYNPO CAV1 PTGIS SLC11A1 CSPG4 RCN3 PLCE1	2.52e-07	193	146	8	469a7f1c2ff7137cc5a064464456911f67f92e70
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PDGFRB SYNPO CAV1 PTGIS SLC11A1 CSPG4 RCN3 PLCE1	2.52e-07	193	146	8	323d1f3f4fbeb93ba857fc135d8aa0b897f98ac5
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BOC NLGN1 PTGIS TMEM132C AEBP1 NT5DC2 C1S RCN3	2.62e-07	194	146	8	7826fe5eb254ac032de0d978f39585a40e0b3ee4
ToppCell	droplet-Bladder-Unstain-18m-Epithelial-bladder_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM23 TNC CAV1 ITGA5 PTGIS FEM1B C1S RCN3	2.62e-07	194	146	8	ee6b5fb4e993a4c0dc556091b8fefd56bdc70d8f
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 PDGFRB TNC PTGIS MOXD1 AEBP1 C1S RCN3	2.62e-07	194	146	8	29f83cdd63314fff41258937d70b881a5503bfcc
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 PDGFRB TNC PTGIS MOXD1 AEBP1 C1S RCN3	2.62e-07	194	146	8	d3db241ea316bbcde6d16618193b474591ad5ce4
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NPHS1 NID2 TNC SYNPO CAV1 AEBP1 C1S PLCE1	2.62e-07	194	146	8	1374600957c7d7f0b05fd2c1186f521b9096d4ef
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB TNC BMPR1B MOXD1 AEBP1 C1S NEURL1B CNTN1	2.73e-07	195	146	8	d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BOC NID2 PDGFRB PTGIS MOXD1 AEBP1 C1S CNTN1	2.73e-07	195	146	8	3c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Bronchial_vessel\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ROBO4 FLNB ADAM23 CAV1 PTGIS ADAMTS9 NEURL1B NOS3	3.18e-07	199	146	8	53b6a661d381b1ed3ea96e61e8bd1750de7d9fda
ToppCell	metastatic_Brain-Fibroblasts-FB-like_cells\|metastatic_Brain / Location, Cell class and cell subclass	NID2 PDGFRB PTGIS TMEM132C MOXD1 AEBP1 C1S RCN3	3.18e-07	199	146	8	12133087eae9f0e9b6c13a71e8187117768e64ce
ToppCell	Parenchyma_Control_(B.)-Endothelial-TX-Bronchial_vessel\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	ROBO4 FLNB ADAM23 CAV1 PTGIS ADAMTS9 NEURL1B NOS3	3.18e-07	199	146	8	9c753043024871b1f1436fc39defac4da85e10cd
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Bronchial_vessel-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ROBO4 FLNB ADAM23 CAV1 PTGIS ADAMTS9 NEURL1B NOS3	3.18e-07	199	146	8	d017dd91f9b10038f1f83753a766e534da2dbe89
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	BOC NID2 PDGFRB PTGIS MOXD1 AEBP1 C1S RCN3	3.18e-07	199	146	8	21335475bbfbad8a6943b8076a6c1c67f3eec5d3
ToppCell	356C-Fibroblasts\|356C / Donor, Lineage, Cell class and subclass (all cells)	BOC PDGFRB CAV1 PTGIS MOXD1 AEBP1 C1S RCN3	3.30e-07	200	146	8	9c95329f0b26ff378de803030d4c28517b3adc85
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	DNAH10 PGGHG MUC16 DNAI1 BMPR1B PLCH1 ANKFN1	8.52e-07	156	146	7	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NID2 MUC16 PTGIS AEBP1 C1S LRRN4 PLCE1	1.35e-06	167	146	7	c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NID2 MUC16 PTGIS AEBP1 C1S LRRN4 PLCE1	1.35e-06	167	146	7	7abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NID2 MUC16 PTGIS AEBP1 C1S LRRN4 PLCE1	1.35e-06	167	146	7	d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NID2 MUC16 PTGIS AEBP1 C1S LRRN4 PLCE1	1.35e-06	167	146	7	351f8de1fbdf742ac74f9099b254d515ab539bb2
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRIM71 DLK1 MOXD1 PTPRK ADAMTS9 NECTIN4 SESN2	1.40e-06	168	146	7	08f6e171a1ea5cf65149744296d0fcd6c7b9684e
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CPAMD8 SRCIN1 CAV1 ADGRV1 BMPR1B PTPRK NECTIN4	1.52e-06	170	146	7	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NID2 MUC16 PTGIS AEBP1 C1S LRRN4 PLCE1	1.70e-06	173	146	7	ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCell	-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	NID2 PDGFRB SIT1 TMEM132C MOXD1 AEBP1 C1S	1.70e-06	173	146	7	88be9182fbb1bc83531cd41e59ea57c112a21d54
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NID2 MUC16 PTGIS AEBP1 C1S LRRN4 PLCE1	1.70e-06	173	146	7	3725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 PTGIS AEBP1 C1S LRRN4 RCN3 PLCE1	1.70e-06	173	146	7	30d67738633493d47f06ae452424382f069b6c0a
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_FOS\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CPAMD8 SELENBP1 PGGHG TNC PRSS29P AEBP1 ADAMTS9	1.77e-06	174	146	7	53c2c132566a7682f3268c7f9138700f09c3b94d
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 PTGIS AEBP1 C1S LRRN4 RCN3 PLCE1	2.06e-06	178	146	7	bcbdd45a2307f8aea14122fa0144b96b1f6eec48
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 PTGIS AEBP1 C1S LRRN4 RCN3 PLCE1	2.06e-06	178	146	7	c413861148129be1ee94f2ceb5999840217eebe5
ToppCell	5'-Adult-Appendix-Neuronal-Glial_mature\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC25A27 L1CAM RGS11 SRCIN1 BMPR1B MOXD1 CNTN1	2.30e-06	181	146	7	3aa81ac64d0cc9a74fbfa71e2176740548e7cd06
ToppCell	5'-Adult-Appendix-Neuronal-Glial_mature-Adult_Glia\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC25A27 L1CAM RGS11 SRCIN1 BMPR1B MOXD1 CNTN1	2.30e-06	181	146	7	997ba1be2824b00d684f2163d0114656ed11fa53
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 PDGFRB TNC RGS11 MOXD1 AEBP1 C1S	2.30e-06	181	146	7	c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCell	5'-Adult-Appendix-Neuronal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC25A27 L1CAM RGS11 SRCIN1 BMPR1B MOXD1 CNTN1	2.30e-06	181	146	7	e6b7e8dd5c13cc10ba22f2f5a8c669486f934bdc
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 PDGFRB TNC RGS11 MOXD1 AEBP1 C1S	2.30e-06	181	146	7	c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCell	E15.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MUC16 CAV1 TST AEBP1 LRRN4 RCN3 PLCE1	2.47e-06	183	146	7	274f274cf60daa30d6a4cd603a3af7823bfb8016
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D231\|Adult / Lineage, Cell type, age group and donor	BOC PDGFRB PTGIS TMEM132C MOXD1 AEBP1 C1S	2.66e-06	185	146	7	fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BOC PDGFRB DLK1 PTGIS AEBP1 C1S ANKFN1	2.75e-06	186	146	7	7582b5154d8e5a4434817b5ab77a10b789ea2288
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB ADAM23 DLK1 PTGIS AEBP1 C1S RCN3	3.06e-06	189	146	7	544d95df910f1b276995624509a7e41b219baca0
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Neuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	GALK2 PGGHG L1CAM CAV1 HMOX1 DUSP26 ADSS2	3.06e-06	189	146	7	3717d1148e26ac78a26aea0ca1dbfbb9d3668877
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	FLNB PTGIS TMEM132C BMPR1B ADAMTS9 DGKI NOS3	3.06e-06	189	146	7	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC25A27 PDGFRB TNC TMEM132C MOXD1 AEBP1 C1S	3.06e-06	189	146	7	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB TNC PTGIS BMPR1B MOXD1 AEBP1 CNTN1	3.06e-06	189	146	7	c734e5693808a0333139e87bd5be2597a9252afe
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAM23 DLK1 CAV1 NT5DC2 CSPG4 CNTN1 MOCOS	3.06e-06	189	146	7	d0c7549be4f77520c23dddf4f94d0fcad0081e37
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 PDGFRB MOXD1 C1S NEURL1B ANKFN1 CNTN1	3.28e-06	191	146	7	a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NPHS1 SELENBP1 MUC16 CAV1 PTGIS AEBP1 LRRN4	3.28e-06	191	146	7	5343a527de6b0f852f45020a91f5b4869e78f13a
ToppCell	COVID-19-kidney-vSMC/Pericyte\|kidney / Disease (COVID-19 only), tissue and cell type	PDGFRB ITGA5 AEBP1 ADAMTS9 CSPG4 NEURL1B PLCE1	3.28e-06	191	146	7	fad8eaa536001b911d05ae2b12150c2398cc6f88
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NPHS1 SELENBP1 MUC16 CAV1 PTGIS AEBP1 LRRN4	3.28e-06	191	146	7	a25a5f9a380031fdaf57677a079f97a90f0550c0
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB TNC PTGIS BMPR1B MOXD1 AEBP1 CNTN1	3.28e-06	191	146	7	806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 PDGFRB TNC PTGIS MOXD1 AEBP1 CNTN1	3.28e-06	191	146	7	107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 PDGFRB TNC PTGIS MOXD1 AEBP1 CNTN1	3.28e-06	191	146	7	bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 PDGFRB MOXD1 C1S NEURL1B ANKFN1 CNTN1	3.28e-06	191	146	7	8f6d592edc32fdb901af30501d4360512334e8c2
ToppCell	droplet-Lung-21m-Mesenchymal\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BOC SELENBP1 PTGIS AEBP1 NT5DC2 C1S RCN3	3.28e-06	191	146	7	10a9db1caa0fdb51ace8537f42b2c66f7c97e0f5
ToppCell	droplet-Lung-1m-Mesenchymal\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BOC SELENBP1 PTGIS AEBP1 NT5DC2 C1S RCN3	3.40e-06	192	146	7	01433bd4794b8bcc51fe4249124a0f4289b9d6e2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BOC NID2 PDGFRB MOXD1 AEBP1 C1S CNTN1	3.40e-06	192	146	7	5105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BOC NID2 PDGFRB MOXD1 AEBP1 C1S CNTN1	3.40e-06	192	146	7	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell\|Adult / Lineage, Cell type, age group and donor	BOC PDGFRB NLGN1 PTGIS AEBP1 C1S ANKFN1	3.40e-06	192	146	7	d21f0f577156f17c899b08871046a26b88aea011
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NID2 PDGFRB CAV1 NT5DC2 CSPG4 CNTN1 MOCOS	3.51e-06	193	146	7	47d189bac0ef4df2f5c6dd987e46aca85bd7e2af
ToppCell	droplet-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM23 TNC PTGIS MOXD1 AEBP1 C1S RCN3	3.51e-06	193	146	7	2d891c00b8f0aace17d4c300b63e2341dcffa199
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NID2 PDGFRB TNC MOXD1 AEBP1 C1S RCN3	3.51e-06	193	146	7	5bee7abc550ddaa28cbb3b9ecaf6b924ab175de0
ToppCell	facs-Lung-nan-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC PDGFRB PTGIS TMEM132C AEBP1 C1S RCN3	3.51e-06	193	146	7	d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DOCK11 DLK1 PTGIS MOXD1 C1S RCN3 PLCE1	3.51e-06	193	146	7	adc9fc94f9ec686a417d08c0b8b7b7ab687afec0
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CPAMD8 AOC1 ADAM23 L1CAM KSR2 BMPR1B MOCOS	3.51e-06	193	146	7	e7012f7b53971972299db34fa51ff51a4e4987fe
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BOC PDGFRB NLGN1 PTGIS TMEM132C AEBP1 C1S	3.51e-06	193	146	7	9ab47b360bee1d4f1092c2269e58acebe9584021
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BOC NID2 PDGFRB PTGIS AEBP1 C1S CNTN1	3.64e-06	194	146	7	c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BOC NID2 PDGFRB MOXD1 AEBP1 C1S RCN3	3.64e-06	194	146	7	02b8102be9414d6964cd71019613edff6d88b893
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB SYNPO PTGIS CSPG4 C1S RCN3 PLCE1	3.64e-06	194	146	7	80be44e9ddd9f6ddd9dff7cba0eb457431204c2d
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Nnat_(Presubiculum,_Col5a2+)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NPHS1 TEX14 LRRN4 ANKFN1 IQCM	3.68e-06	71	146	5	3f7ab70a5451043019f6e56c16ab95182ff44a15
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Nnat_(Presubiculum,_Col5a2+)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NPHS1 TEX14 LRRN4 ANKFN1 IQCM	3.68e-06	71	146	5	f0af76191cb0e29abf6e7d1a6f5a0df1ad837ce7
ToppCell	COVID-19-kidney-PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	BOC ROBO4 SMCHD1 SYNPO ITGA5 NEURL1B NOS3	3.76e-06	195	146	7	a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PDGFRB NLGN1 PTGIS TMEM132C MOXD1 AEBP1 C1S	3.76e-06	195	146	7	ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
ToppCell	facs-Bladder-nan-3m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM23 TNC MOXD1 AEBP1 ADAMTS9 C1S RCN3	3.76e-06	195	146	7	18b01ab63ee1deae3cf29669d66fff9ca4efc5c4
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	BOC ROBO4 FLNB SYNPO ITGA5 ADAMTS9 NOS3	3.76e-06	195	146	7	818bc18c5834238e5f733cac6fe928ed0788f57d
ToppCell	Endothelial-A-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	ROBO4 SYNPO CAV1 ITGA5 PTGIS ADAMTS9 NOS3	3.76e-06	195	146	7	c3a0aa34b672c99cb3a2a4e9218412dbd19da3ca
ToppCell	Bronchial_Biopsy-Mesenchymal-Fibroblasts\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	PDGFRB RGS11 PTGIS TMEM132C MOXD1 AEBP1 RCN3	3.76e-06	195	146	7	5870b2956d50d6550a3174a220a6cc70c5538d70
ToppCell	(3)_Chondrocytes-(34)_Chondro-progen\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	BOC DLK1 SRCIN1 PTGIS ANKH MOXD1 KLC3	3.76e-06	195	146	7	d00cb2fab25f2026a9668a7f0686938a2e7155e2
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB TNC BMPR1B MOXD1 AEBP1 C1S CNTN1	3.89e-06	196	146	7	a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCell	droplet-Limb_Muscle-nan-24m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC TNC PTGIS TXNRD1 AEBP1 C1S RCN3	3.89e-06	196	146	7	61bee32ca299219f31a30b57124e44e85b798e9f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	BOC ROBO4 CPAMD8 SYNPO ITGA5 ADAMTS9 NOS3	3.89e-06	196	146	7	4cd1e6b7a791e11a40b19f971b7011bd11fe6273
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	BOC ROBO4 CPAMD8 SYNPO ITGA5 ADAMTS9 NOS3	3.89e-06	196	146	7	d37f714d4fb57e958f3738fdda085560813e5bb5
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB TNC BMPR1B MOXD1 AEBP1 C1S CNTN1	3.89e-06	196	146	7	3e6803587d8566fd08cb8b290be3b6461743d79c
ToppCell	15-Trachea-Mesenchymal-Mesenchyme_SERPINF1-high\|Trachea / Age, Tissue, Lineage and Cell class	BOC NID2 PDGFRB DLK1 AEBP1 C1S RCN3	3.89e-06	196	146	7	54aefcebf13704f51de84379e2e22ec0734b9461
Drug	4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid	NPHS1 HMOX1 FASN NOS3	2.42e-06	16	141	4	ctd:C524106
Drug	AC1L1HQG	TNC CAV1 HMOX1 PTGIS CLCN3 LNPEP NOS3 SMAD4	2.96e-06	142	141	8	CID000004246
Disease	Hereditary Diffuse Gastric Cancer	SELENBP1 CAV1 HMOX1 ITGA5 NBAS CLCN3 NOS3 SMAD4 PLCE1	1.24e-05	293	141	9	C1708349
Disease	Stomach Neoplasms	SELENBP1 CAV1 HMOX1 ITGA5 NBAS CLCN3 NOS3 SMAD4 PLCE1	1.38e-05	297	141	9	C0038356
Disease	Malignant neoplasm of stomach	SELENBP1 CAV1 HMOX1 ITGA5 NBAS CLCN3 NOS3 SMAD4 PLCE1	1.49e-05	300	141	9	C0024623
Disease	NEPHROTIC SYNDROME, TYPE 3	NPHS1 PLCE1	2.27e-05	2	141	2	C1853124
Disease	pulmonary hypertension (biomarker_via_orthology)	TNC CAV1 HMOX1 NOS3 SMAD4	4.18e-05	80	141	5	DOID:6432 (biomarker_via_orthology)
Disease	Idiopathic pulmonary arterial hypertension	CAV1 BMPR1B SMAD4	5.71e-05	16	141	3	C3203102
Disease	lean body mass	GLYAT GPAM DLK1 ADGRV1 MOXD1 DGKI PLEC NOS3 PLCE1	9.13e-05	379	141	9	EFO_0004995
Disease	HbA1c measurement	CPAMD8 RGS11 DLK1 NLGN1 ITGAD ITGAX ANKH TFR2 AEBP1 C1S MYO15A MAP4K2	1.01e-04	675	141	12	EFO_0004541
Disease	pulmonary hypertension (implicated_via_orthology)	TNC HMOX1 PTGIS NOS3	1.31e-04	54	141	4	DOID:6432 (implicated_via_orthology)
Disease	ileus (biomarker_via_orthology)	HMOX1 NOS3	2.25e-04	5	141	2	DOID:8440 (biomarker_via_orthology)
Disease	renal hypertension (implicated_via_orthology)	HMOX1 NOS3	2.25e-04	5	141	2	DOID:1073 (implicated_via_orthology)
Disease	limb ischemia (implicated_via_orthology)	HMOX1 NOS3	2.25e-04	5	141	2	DOID:0050852 (implicated_via_orthology)
Disease	pulmonary hypertension (is_marker_for)	TNC CAV1 BMPR1B NOS3	2.54e-04	64	141	4	DOID:6432 (is_marker_for)
Disease	leiomyoma (is_marker_for)	CAV1 LNPEP NOS3	3.21e-04	28	141	3	DOID:127 (is_marker_for)
Disease	acute chest syndrome (is_implicated_in)	HMOX1 NOS3	3.36e-04	6	141	2	DOID:1584 (is_implicated_in)
Disease	hepatopulmonary syndrome (biomarker_via_orthology)	HMOX1 NOS3	3.36e-04	6	141	2	DOID:900 (biomarker_via_orthology)
Disease	hydrocephalus (is_implicated_in)	L1CAM TRIM71	3.36e-04	6	141	2	DOID:10908 (is_implicated_in)
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	AOC1 DNAH10 ACO2 SMCHD1 NLGN1 EML3 HTT PLCE1	3.79e-04	364	141	8	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	Colorectal Neoplasms	BOC CPAMD8 SELENBP1 TXNRD1 MLH3 SESN2 SMAD4	3.86e-04	277	141	7	C0009404
Disease	endoplasmic reticulum aminopeptidase 1 measurement	ERAP1 LNPEP	4.69e-04	7	141	2	EFO_0008119
Disease	fructosamine measurement	MAP4K2 RCN3	4.69e-04	7	141	2	EFO_0009303
Disease	endometrial carcinoma (is_marker_for)	ERAP1 NOS3 SMAD4	5.73e-04	34	141	3	DOID:2871 (is_marker_for)
Disease	body fat percentage	DMXL2 AOC1 DNAH10 ACO2 SMCHD1 NLGN1 EML3 HTT PLCE1	5.87e-04	488	141	9	EFO_0007800
Disease	Eczema, allergic rhinitis	TNC ANKH PTPRK CD200R1L NOS3 SMAD4	6.04e-04	215	141	6	EFO_0005854, HP_0000964
Disease	severe pre-eclampsia (is_marker_for)	ERAP1 LNPEP	6.23e-04	8	141	2	DOID:13129 (is_marker_for)
Disease	brain ischemia (implicated_via_orthology)	HMOX1 PTGIS NOS3	6.25e-04	35	141	3	DOID:2316 (implicated_via_orthology)
Disease	Nonsyndromic Deafness	TNC TPRN ADGRV1 MYO15A	6.25e-04	81	141	4	C3711374
Disease	Cardiomegaly	AOC1 CAV1 HMOX1 NOS3	6.55e-04	82	141	4	C0018800
Disease	Cardiac Hypertrophy	AOC1 CAV1 HMOX1 NOS3	6.55e-04	82	141	4	C1383860
Disease	Idiopathic pulmonary hypertension	BMPR1B SMAD4	7.98e-04	9	141	2	C0152171
Disease	waist-hip ratio	NID2 CPAMD8 DMXL2 DNAH10 ADAM23 SMCHD1 HMGXB4 TM6SF2 PTGIS BMPR1B P4HTM ADAMTS9 NEURL1B HTT PLCE1	8.00e-04	1226	141	15	EFO_0004343
Disease	autism spectrum disorder (implicated_via_orthology)	PDGFRB NLGN1 PKP2 NLGN2 MOCOS	8.37e-04	152	141	5	DOID:0060041 (implicated_via_orthology)
Disease	Paroxysmal atrial fibrillation	USP34 DNAH10 CAV1 PKP2 NOS3	9.40e-04	156	141	5	C0235480
Disease	familial atrial fibrillation	USP34 DNAH10 CAV1 PKP2 NOS3	9.40e-04	156	141	5	C3468561
Disease	Persistent atrial fibrillation	USP34 DNAH10 CAV1 PKP2 NOS3	9.40e-04	156	141	5	C2585653
Disease	Essential hypertension	PTGIS NOS3	9.95e-04	10	141	2	cv:C0085580
Disease	Essential hypertension, genetic	PTGIS NOS3	9.95e-04	10	141	2	cv:CN305331
Disease	HYPERTENSION, ESSENTIAL	PTGIS NOS3	9.95e-04	10	141	2	145500
Disease	Pulmonary arterial hypertension	CAV1 SMAD4	9.95e-04	10	141	2	C2973725
Disease	Atrial Fibrillation	USP34 DNAH10 CAV1 PKP2 NOS3	1.05e-03	160	141	5	C0004238
Disease	myocardial infarction (biomarker_via_orthology)	TNC HMOX1 TXNRD1 NOS3 SMAD4	1.05e-03	160	141	5	DOID:5844 (biomarker_via_orthology)
Disease	colitis (biomarker_via_orthology)	SI HMOX1 NOS3	1.07e-03	42	141	3	DOID:0060180 (biomarker_via_orthology)
Disease	liver fat measurement	GPAM TM6SF2 PLEC	1.15e-03	43	141	3	EFO_0010821
Disease	Gastric Adenocarcinoma	PDGFRB TEX14 BMPR1B	1.31e-03	45	141	3	C0278701
Disease	Essential Hypertension	PTGIS NOS3	1.45e-03	12	141	2	C0085580
Disease	type 2 diabetes mellitus (implicated_via_orthology)	FEM1B ADAMTS9 LNPEP RHEBL1	1.64e-03	105	141	4	DOID:9352 (implicated_via_orthology)
Disease	ocular hypertension, response to triamcinolone acetonide	VWA8 TEX14 TMEM132C	1.68e-03	49	141	3	EFO_0006954, EFO_1001069
Disease	juvenile polyposis syndrome (implicated_via_orthology)	BMPR1B SMAD4	1.71e-03	13	141	2	DOID:0050787 (implicated_via_orthology)
Disease	Leishmaniasis, Visceral	HMOX1 SLC11A1	1.71e-03	13	141	2	C0023290
Disease	Streptozotocin Diabetes	GPAM CAV1 HMOX1 NOS3	1.82e-03	108	141	4	C0038433
Disease	Diabetes Mellitus, Experimental	GPAM CAV1 HMOX1 NOS3	1.82e-03	108	141	4	C0011853
Disease	Alloxan Diabetes	GPAM CAV1 HMOX1 NOS3	1.82e-03	108	141	4	C0002152
Disease	2-oxo-hept-3-ene-1,7-dioate hydratase activity	CAV1 SMAD4	1.99e-03	14	141	2	C1150929
Disease	Autosomal recessive limb-girdle muscular dystrophy	POMGNT1 PLEC	1.99e-03	14	141	2	cv:C2931907
Disease	HMG CoA reductase inhibitor use measurement	GLYAT TM6SF2 BMPR1B PLEC NOS3	2.19e-03	189	141	5	EFO_0009932
Disease	Hypertensive disease	AOC1 ERAP1 CAV1 HMOX1 NOS3	2.24e-03	190	141	5	C0020538
Disease	high grade glioma (biomarker_via_orthology)	TNC CAV1	2.29e-03	15	141	2	DOID:3070 (biomarker_via_orthology)
Disease	ovarian cancer (is_implicated_in)	MUC16 NOS3 SMAD4	2.46e-03	56	141	3	DOID:2394 (is_implicated_in)
Disease	Diabetic Angiopathies	HMOX1 NOS3	2.60e-03	16	141	2	C0011875
Disease	transferrin saturation measurement	TFR2 ERFE	2.60e-03	16	141	2	EFO_0006333
Disease	Microangiopathy, Diabetic	HMOX1 NOS3	2.60e-03	16	141	2	C0025945
Disease	Blood Coagulation Disorders	HMOX1 SMAD4	2.60e-03	16	141	2	C0005779
Disease	Pre-Eclampsia	HMOX1 NOS3	2.60e-03	16	141	2	C0032914
Disease	cortical thickness	FLNB CPAMD8 GALK2 ABCF3 AS3MT ADGRV1 ADAMTS9 NT5DC2 DGKI PLEC PLCH1 ANKFN1 PLCE1	2.68e-03	1113	141	13	EFO_0004840
Disease	Familial primary pulmonary hypertension	CAV1 SMAD4	2.94e-03	17	141	2	C0340543
Disease	Adenocarcinoma of lung (disorder)	GRWD1 FBL KSR2 ARG1 FASN	3.17e-03	206	141	5	C0152013
Disease	asthma (is_marker_for)	TNC HMOX1 ARG1 BMPR1B	3.19e-03	126	141	4	DOID:2841 (is_marker_for)
Disease	essential hypertension (is_implicated_in)	PTGIS NOS3	3.30e-03	18	141	2	DOID:10825 (is_implicated_in)
Disease	Tourette syndrome, schizophrenia	DNAH10 NSD3	3.30e-03	18	141	2	EFO_0004895, MONDO_0005090
Disease	renal cell carcinoma (is_marker_for)	PDGFRB CAV1 LNPEP SMAD4	3.37e-03	128	141	4	DOID:4450 (is_marker_for)
Disease	Calcium channel blocker use measurement	USP34 ERAP1 AS3MT NOS3 PLCE1	3.66e-03	213	141	5	EFO_0009930
Disease	portal hypertension (implicated_via_orthology)	HMOX1 NOS3	3.68e-03	19	141	2	DOID:10762 (implicated_via_orthology)
Disease	osteochondrodysplasia (is_implicated_in)	FLNB BMPR1B	3.68e-03	19	141	2	DOID:2256 (is_implicated_in)
Disease	polycystic kidney disease (biomarker_via_orthology)	TNC NOS3	3.68e-03	19	141	2	DOID:0080322 (biomarker_via_orthology)
Disease	ovarian neoplasm	SELENBP1 MUC16 CAV1 FASN	3.97e-03	134	141	4	C0919267
Disease	Fetal Growth Retardation	DLK1 NOS3	4.07e-03	20	141	2	C0015934
Disease	schizophrenia (implicated_via_orthology)	PDGFRB NCSTN NLGN2	4.27e-03	68	141	3	DOID:5419 (implicated_via_orthology)
Disease	Malignant neoplasm of ovary	SELENBP1 MUC16 CAV1 FASN	4.30e-03	137	141	4	C1140680
Disease	Lung Injury	TNC HMOX1	4.49e-03	21	141	2	C0273115
Disease	Chronic Lung Injury	TNC HMOX1	4.49e-03	21	141	2	C2350344
Disease	cataract	CPAMD8 PKD1L1 NT5DC2 PLCE1	4.76e-03	141	141	4	MONDO_0005129

Protein segments in the cluster

Peptide	Gene	Start	Entry
IYVGDGYVVHLAPAS	PLAAT2	26	Q9NWW9
GIIHQIILENYAYPG	ACO2	171	Q99798
GEIIPTSFYHQGRVI	ADAM23	676	O75077
NLEPGYDFLHIYDGR	CSMD2	1491	Q7Z408
EAAYRLIQGPQYGHL	CSPG4	1976	Q6UVK1
YHGYVEGVPESLVAL	ADAM20	111	O43506
LNPGEYRVTAHAEGY	AEBP1	946	Q8IUX7
PEEEYRHQLGRYGIS	ABCF3	586	Q9NUQ8
PVVRLHGTYGYVTAD	ADGRV1	4421	Q8WXG9
EDPFGVYHVNLEGVI	ADPRM	286	Q3LIE5
YGPAYFGQEHARVLS	DMXL2	1501	Q8TDJ6
PYLVAVGHYDGNVAI	DNAI1	396	Q9UI46
YVEGYFLHPTGLELL	AOC1	206	P19801
YGAEIRPSLESLGYH	ANGEL2	226	Q5VTE6
GYGLAYRLTPGVHEL	DLK1	261	P80370
SGGIVEEYQLPYHDL	BMPR1B	416	O00238
GHLYTVPIREQGNIY	CAV1	11	Q03135
ADGYGYPRGRHILSV	CERS5	36	Q8N5B7
FIGYVGEELIYLDPH	ATG4B	266	Q9Y4P1
YIGLRDVDPGEHYIL	ARG1	176	P05089
QALLGTEHGDYYSPR	C17orf113	161	A0A1B0GUU1
SEPLQVVRYGEGGHY	P4HTM	311	Q9NXG6
EELRNATYGHYAPGE	RCN3	136	Q96D15
EYSILPYSFIIGVHG	RHEBL1	66	Q8TAI7
GDVPEARYGHSINVV	RAG2	131	P55895
GAVLVQHGYIYPLRD	RGS11	76	O94810
GEEGYRYIVNGHPAL	IQCM	456	A0A1B0GVH7
GSTDLVLIGAPHYYE	ITGAX	471	P20702
VLIGAPHYYEQTRGG	ITGAX	476	P20702
DLRSYLGDGPLQHYI	NCSTN	541	Q92542
PGLYYVDEHGTRLSG	PSMB8	181	P28062
EHYILTFPNGYGRSI	OSBPL9	551	Q96SU4
IYHATGPLEERQIAY	MAP4K2	101	Q12851
VFITGHRGQPYTYDA	RADX	466	Q6NSI4
YPGNYHTLFGVRNEE	ANO7	616	Q6IWH7
GPYTLDRHSLYVNGF	MUC16	13426	Q8WXI7
RYEALGTPGFHYVDV	NPHS1	976	O60500
HAVIDINAFPGYEGV	ITPK1	291	Q13572
GTYVVSYRPQLEGEH	TRIM71	546	Q2Q1W2
VEYPAGDLSGHLLAY	DOLPP1	21	Q86YN1
EEAYVLYHRAQTGAP	GRWD1	51	Q9BQ67
RLPSQYIYGFGETEH	MGAM2	1081	Q2M2H8
LHRYEEQEPYLAGLG	MYO15A	251	Q9UKN7
YTHVDRLTVDAYPGL	KSR2	221	Q6VAB6
AGTLPEYRLHGLVTY	GLYAT	231	Q6IB77
IDVSHPIIYRGAVYA	FEM1B	341	Q9UK73
QIRPVDTTHDGYYRG	CD200R1L	111	Q6Q8B3
DTTHDGYYRGIVVTP	CD200R1L	116	Q6Q8B3
VGLPYTVVIHYAGNL	ERAP1	141	Q9NZ08
EGLYAVDVTYDGHPV	FLNB	1011	O75369
YEQHRKYGALPDQGI	IGBP1	271	P78318
HRSTPELYGIYVINV	MLH3	296	Q9UHC1
LHELGVYYLPDAEGA	ERFE	221	Q4G0M1
VGPDGLVYAVEFSHR	FBL	181	P22087
FYVRAPGRVNIIGEH	GALK2	36	Q01415
EYAYHGQIAIVAPEA	LNPEP	236	Q9UIQ6
GVLTGYVLSYHPLDE	L1CAM	946	P32004
GYEYVVARPEQGALL	SLC11A1	211	P49279
YARALSIYEALGGPH	KLC3	356	Q6P597
EGALGPHVVTNLYLY	MOCOS	576	Q96EN8
PDFQGARYLYGHTLT	PGGHG	151	Q32M88
YRVTIVADHPGIDFG	HMGXB4	421	Q9UGU5
RYHIAFGPVIDGDVI	NLGN1	391	Q8N2Q7
GCRHLLETPGQYLVY	EXOC8	171	Q8IYI6
YIYPTIGGFDHERLQ	NBAS	1746	A2RRP1
AYRTQDGLGPLHYGV	NOS3	961	P29474
IRYAIGVGHAFQGPT	ITGAD	281	Q13349
LLEHYGGTPRDDQYV	NID2	1026	Q14112
EYLPEQRSHLYGITA	NID2	1351	Q14112
EVGRVYVYLQHPAGI	ITGA5	361	P08648
TVHYGYNTVVRIPAG	ADAMTS9	761	Q9P2N4
YIDHGDPQVRGATAI	HTT	756	P42858
RHEGSGRAPILYYVV	BOC	496	Q9BWV1
PESYIHGIAESQLRY	DOCK11	446	Q5JSL3
VHYAGYNVTRPEGDL	B4GALT6	301	Q9UBX8
PQRHDDGYIEVIGFT	DGKI	631	O75912
NGVGYYSHEVGRPVL	CPAMD8	271	Q8IZJ3
HLYVVSYVNPGEVTR	DPP8	551	Q6V1X1
TVTGYKVLYRPDGQH	CNTN1	936	Q12860
DIEVPEGYGIHLYFT	C1S	41	P09871
GYYKNIHDIIPDRSG	ANKH	211	Q9HCJ1
LRYYGCGLVIPEHLE	AS3MT	56	Q9HBK9
GVYFEVHTPGVYRDL	FBXO24	321	O75426
PELLVAHAYTRYLGD	HMOX1	126	P09601
VRYSPDGLYLAIGSH	EML3	686	Q32P44
HIADPSAYGIYILDR	GYS1	541	P13807
LRGYDYGPHFQGILE	FASN	996	P49327
EVFGLHPNAEIGYYT	DNAH10	4156	Q8IVF4
RTPEGIYRYGNHTGE	RNF103	291	O00237
GGRAVYDIVHFQPYS	DSEL	441	Q8IZU8
RYHIAFGPVVDGDVV	NLGN2	346	Q8NFZ4
HGRDTQYYFVLPAGE	PKD1L1	1241	Q8TDX9
VGVIYATARQHPLYG	LRRN4	626	Q8WUT4
VPYDHQRGFSGIFED	PDGFRB	171	P09619
IDGYQRPSHYIATQG	PTPRK	946	Q15262
IDPFHYNYQTLRIGG	FXYD6P3	26	P58550
TYPLRIYAGHLADVD	TAF5L	416	O75529
DHGYSLIQRLYPEGG	SESN2	346	P58004
SVHLYYLFPSLEEGG	DROSHA	981	Q9NRR4
GVVEGIIRYHPFLYD	SMCHD1	421	A6NHR9
VQRYGLHPDVNVYLG	TEX14	531	Q8IWB6
TDPSIYRIHAGDVYL	PRSS29P	121	A6NIE9
VELYYTVHPGNERGD	TMEM132C	226	Q8N3T6
YQEDGRYEGPTLAHA	PLCE1	1031	Q9P212
GYLTLYGIEALPRTH	PTGIS	176	Q16647
ASLYHGYLPENGVLR	SYNPO	786	Q8N3V7
RYIEHYTLQPETGAL	SAMD9L	176	Q8IVG5
VAEYGRYTGVRIIHP	SAMD9L	976	Q8IVG5
IIPDVSRSYHFGIVG	POMGNT1	491	Q8WZA1
PVGISYDRIIEGHYN	GPAM	351	Q9HCL2
YHYERVVSPGIDLSG	SMAD4	131	Q13485
PADVEAGLYGSHLYV	SELENBP1	216	Q13228
LPSEYIYGFGEVEHT	SI	1106	P14410
VRDGVYFLYEALHGP	ADSS2	231	P30520
VVEVYLHPGAVVFGR	SPG7	191	Q9UQ90
YEGLGIRYLGVEAHD	DUSP26	106	Q9BV47
VDDLYGTLYVPHDGT	SARDH	196	Q9UL12
RVHLGPGLYRYTSED	ROBO4	496	Q8WZ75
YEGLELPRVNYAHNG	BCO1	401	Q9HAY6
GTHNLGRVYYEPIKD	ANKFN1	526	Q8N957
PLYNFIRDGELQYHG	ANGEL1	441	Q9UNK9
REGIYEAHIRLNGYP	CLCN3	626	P51790
IYIDELYGGLQRPSE	CLASRP	136	Q8N2M8
VYENAYGQFIGPHRI	TXNRD1	276	Q16881
EAQYLRYHDIEPGAV	PDCD11	441	Q14690
YVLIGSGLYDEAIRH	TTC13	151	Q8NBP0
VVGGVAHGRPYLQDY	MOXD1	76	Q6UVY6
YADPYGLLHEGRLSL	SRCIN1	396	Q9C0H9
YRSHPVDVYAGFLIG	PLPPR3	256	Q6T4P5
HGRVFYSVNDGEPVL	NEURL1B	151	A8MQ27
EYLVVYTPTHEGGLE	TNC	651	P24821
VTPAIYRHVVYSGGR	SLC25A27	91	O95847
HGDPLSYYQTGDIIR	TTC14	176	Q96N46
VIELYGGTQHIPLYQ	NT5DC2	156	Q9H857
LGFHLPLEVAYQRGY	PLEC	3951	Q15149
GYHEALTRVQSYGPE	ZC3H12B	631	Q5HYM0
VHQGRVFPYVEGDKS	NSD3	1011	Q9BZ95
SLVPGYRHVYLEGLT	PLCH1	831	Q4KWH8
YPTVHEIEVIGGYLA	TPRN	546	Q4KMQ1
YTKEGEPYLRTAHGV	TM6SF2	96	Q9BZW4
DGGHYYSFIRDIVNP	USP34	2161	Q70CQ2
VVVYDGEHLGSFYAP	TST	96	Q16762
GPYRLDAGHTVYQVS	VWA8	1586	A3KMH1
PHRIGLYLHYEQGEL	TRIM50	411	Q86XT4
GRHLLIDANGVPYTY	ZNF580	51	Q9UK33
RLGHEPGLVQLVNYY	TTL	51	Q8NG68
LVHYVRGTIADYQPD	PKP2	586	Q99959
VTGELVYAHYGRPED	TFR2	241	Q9UP52
GESVEEVPLYGNLHY	SIT1	81	Q9Y3P8
EVPLYGNLHYLQTGR	SIT1	86	Q9Y3P8
YGLHVSPAYEGRVEQ	NECTIN4	86	Q96NY8