Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainPID_Shc-like

SHC1 SHC4 SHC2

1.19e-0641263IPR006019
DomainSH2

SHC1 SHC4 SLA SHC2 SOCS5 SOCS4 PLCG1

5.47e-061011267PF00017
DomainSH2

SHC1 SHC4 SLA SHC2 SOCS5 SOCS4 PLCG1

9.62e-061101267SM00252
DomainSH2

SHC1 SHC4 SLA SHC2 SOCS5 SOCS4 PLCG1

1.02e-051111267PS50001
DomainSH2

SHC1 SHC4 SLA SHC2 SOCS5 SOCS4 PLCG1

1.08e-051121267IPR000980
Domain-

SHC1 SHC4 SLA SHC2 SOCS5 SOCS4 PLCG1

1.08e-0511212673.30.505.10
DomainSOCS

SOCS5 SOCS4

4.52e-0521262PF12610
DomainSOCS4/SOCS5_dom

SOCS5 SOCS4

4.52e-0521262IPR022252
DomainTRP_channel

TRPV1 TRPC7 TRPC6

4.75e-05111263IPR004729
Domain-

RANBP2 MYO7B SHC1 SHC4 PLEKHH1 MTMR7 MTMR4 SHC2 PLCG1 PLD1

3.22e-04391126102.30.29.30
DomainFATC

SMG1 ATR

4.46e-0451262PF02260
DomainARM-like

SMG1 IPO7 ATR COPG2 XPO1 NCAPD2 STAG2 AGTPBP1

4.97e-042701268IPR011989
DomainPH_dom-like

RANBP2 MYO7B SHC1 SHC4 PLEKHH1 MTMR7 MTMR4 SHC2 PLCG1 PLD1

6.28e-0442612610IPR011993
DomainTRP_2

TRPC7 TRPC6

6.65e-0461262PF08344
DomainTRP_dom

TRPC7 TRPC6

6.65e-0461262IPR013555
DomainFAT

SMG1 ATR

6.65e-0461262PS51189
DomainFATC

SMG1 ATR

6.65e-0461262PS51190
DomainFATC_dom

SMG1 ATR

6.65e-0461262IPR003152
DomainPIK_FAT

SMG1 ATR

6.65e-0461262IPR014009
DomainFATC

SMG1 ATR

6.65e-0461262SM01343
DomainPID

SHC1 SHC4 SHC2

8.68e-04281263PF00640
DomainTRPC_channel

TRPC7 TRPC6

9.27e-0471262IPR002153
DomainEphrin

EFNA1 EFNA3

1.23e-0381262PF00812
DomainEphrin_RBD

EFNA1 EFNA3

1.23e-0381262IPR001799
DomainEphrin

EFNA1 EFNA3

1.23e-0381262PD002533
DomainEphrin

EFNA1 EFNA3

1.23e-0381262IPR031328
DomainEPHRIN_RBD_1

EFNA1 EFNA3

1.23e-0381262PS01299
DomainEphrin_CS

EFNA1 EFNA3

1.23e-0381262IPR019765
DomainEPHRIN_RBD_2

EFNA1 EFNA3

1.23e-0381262PS51551
DomainCH

CFAP47 SYNE1 LRCH1 DST

1.28e-03701264PF00307
DomainHEAT_REPEAT

SMG1 ATR COPG2 XPO1

1.28e-03701264PS50077
DomainPID

SHC1 SHC4 SHC2

1.29e-03321263PS01179
Domain-

CFAP47 SYNE1 LRCH1 DST

1.35e-037112641.10.418.10
DomainCH

CFAP47 SYNE1 LRCH1 DST

1.50e-03731264PS50021
DomainMYTH4

MYO7B PLEKHH1

1.58e-0391262PS51016
DomainMyTH4

MYO7B PLEKHH1

1.58e-0391262SM00139
DomainMyTH4_dom

MYO7B PLEKHH1

1.58e-0391262IPR000857
DomainMyTH4

MYO7B PLEKHH1

1.58e-0391262PF00784
DomainCH-domain

CFAP47 SYNE1 LRCH1 DST

1.66e-03751264IPR001715
DomainARM-type_fold

SMG1 IPO7 ATR COPG2 XPO1 NCAPD2 STAG2 AGTPBP1

2.13e-033391268IPR016024
DomainPKD_channel

PKD1 MCOLN3

2.39e-03111262PF08016
DomainPKD1_2_channel

PKD1 MCOLN3

2.39e-03111262IPR013122
DomainPTB

SHC1 SHC4 SHC2

2.47e-03401263SM00462
DomainPTB/PI_dom

SHC1 SHC4 SHC2

2.65e-03411263IPR006020
DomainMyotubularin-like_Pase_dom

MTMR7 MTMR4

3.90e-03141262IPR010569
DomainIMPORTIN_B_NT

IPO7 XPO1

3.90e-03141262PS50166
Domain-

EFNA1 EFNA3

3.90e-031412622.60.40.420
DomainPPASE_MYOTUBULARIN

MTMR7 MTMR4

3.90e-03141262PS51339
DomainMyotubularin_fam

MTMR7 MTMR4

3.90e-03141262IPR030564
DomainMyotub-related

MTMR7 MTMR4

3.90e-03141262PF06602
Domain-

REXO5 POLA1 PIWIL2

3.92e-034712633.30.420.10
Domain-

IPO7 ATR COPG2 XPO1 NCAPD2 AGTPBP1

3.98e-0322212661.25.10.10
DomainClathrin/coatomer_adapt-like_N

COPG2 NCAPD2

4.48e-03151262IPR002553
DomainPI3/4_kinase_CS

SMG1 ATR

4.48e-03151262IPR018936
DomainAdaptin_N

COPG2 NCAPD2

4.48e-03151262PF01602
DomainIBN_N

IPO7 XPO1

4.48e-03151262PF03810
Domain-

SMG1 ATR

5.09e-031612621.10.1070.11
DomainIBN_N

IPO7 XPO1

5.09e-03161262SM00913
DomainPI3Kc

SMG1 ATR

5.09e-03161262SM00146
DomainQuinoprotein_ADH-like_supfam

WDR6 WDR87 CFAP57

5.49e-03531263IPR011047
DomainImportin-beta_N

IPO7 XPO1

5.75e-03171262IPR001494
DomainPI3_PI4_kinase

SMG1 ATR

6.44e-03181262PF00454
DomainPI3_4_KINASE_1

SMG1 ATR

6.44e-03181262PS00915
DomainPI3_4_KINASE_2

SMG1 ATR

6.44e-03181262PS00916
DomainPI3/4_kinase_cat_dom

SMG1 ATR

6.44e-03181262IPR000403
DomainPI3_4_KINASE_3

SMG1 ATR

6.44e-03181262PS50290
PathwayREACTOME_SIGNALLING_TO_ERKS

MAPKAPK2 SHC1 SHC2 MAP2K1 MAP2K2

1.05e-06261025MM14716
PathwayREACTOME_SIGNALLING_TO_ERKS

MAPKAPK2 SHC1 SHC2 MAP2K1 MAP2K2

4.23e-06341025M13881
PathwayKEGG_GLIOMA

SHC1 SHC4 SHC2 PLCG1 MAP2K1 MAP2K2

7.24e-06651026M1835
PathwayREACTOME_SIGNALING_BY_NTRKS

MAPKAPK2 SHC1 SHC2 PLCG1 MAP2K1 MAP2K2

1.66e-05751026MM14652
PathwayKEGG_VEGF_SIGNALING_PATHWAY

MAPKAPK2 SHC2 PLCG1 MAP2K1 MAP2K2 NOS3

1.80e-05761026M1749
PathwayWP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE

SHC1 SHC4 SHC2 PLCG1 MAP2K1 MAP2K2

3.19e-05841026M39839
PathwayBIOCARTA_PYK2_PATHWAY

SHC1 PLCG1 MAP2K1 MAP2K2

3.42e-05261024MM1431
PathwayKEGG_NEUROTROPHIN_SIGNALING_PATHWAY

MAPKAPK2 SHC1 SHC4 SHC2 PLCG1 MAP2K1 MAP2K2

3.52e-051261027M16763
PathwayKEGG_ERBB_SIGNALING_PATHWAY

SHC1 SHC4 SHC2 PLCG1 MAP2K1 MAP2K2

3.89e-05871026M12467
PathwayBIOCARTA_PYK2_PATHWAY

SHC1 PLCG1 MAP2K1 MAP2K2

3.99e-05271024M7739
PathwayREACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN_1_SIGNALING

TRPC7 TRPC6 PLCG1

4.25e-05101023M27330
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_PATHWAY_ADAPTOR_PROTEINS

SHC1 SHC4 SHC2

4.25e-05101023M47930
PathwayREACTOME_TRP_CHANNELS

TRPV1 TRPC7 TRPC6 MCOLN3

4.63e-05281024MM14943
PathwayREACTOME_TRP_CHANNELS

TRPV1 TRPC7 TRPC6 MCOLN3

4.63e-05281024M27241
PathwayWP_ERBB_SIGNALING

SHC1 SHC4 SHC2 PLCG1 MAP2K1 MAP2K2

5.34e-05921026M39715
PathwayBIOCARTA_BIOPEPTIDES_PATHWAY

SHC1 PLCG1 MAP2K1 MAP2K2

5.34e-05291024MM1356
PathwayBIOCARTA_BIOPEPTIDES_PATHWAY

SHC1 PLCG1 MAP2K1 MAP2K2

5.34e-05291024M13494
PathwayREACTOME_SIGNALLING_TO_RAS

MAPKAPK2 SHC1 SHC2

7.72e-05121023MM14657
PathwayWP_BDNFTRKB_SIGNALING

TRPC6 SHC1 PLCG1 MAP2K1

9.00e-05331024M39532
PathwayREACTOME_SIGNALING_BY_NTRK1_TRKA

MAPKAPK2 SHC1 SHC2 MAP2K1 MAP2K2

9.05e-05631025MM14714
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

SHC1 EFNA1 EFNA3 ST8SIA2 PLCG1 MAP2K1 MAP2K2 EPHA10 PLXNB1

1.14e-042611029MM15676
PathwayWP_BREAST_CANCER_PATHWAY

ATR SHC1 SHC4 FZD8 SHC2 MAP2K1 MAP2K2

1.26e-041541027M39739
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY

PLCG1 MAP2K1 MAP2K2

1.26e-04141023M47383
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY

PLCG1 MAP2K1 MAP2K2

1.26e-04141023M47384
PathwayPID_VEGFR1_2_PATHWAY

MAPKAPK2 PLCG1 MAP2K1 MAP2K2 NOS3

1.40e-04691025M237
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY

PLCG1 MAP2K1 MAP2K2

1.57e-04151023M47382
PathwayWP_KIT_RECEPTOR_SIGNALING_PATHWAY

SHC1 SOCS5 SOCS4 PLCG1 MAP2K1

1.60e-04711025MM15947
PathwayKEGG_CHRONIC_MYELOID_LEUKEMIA

SHC1 SHC4 SHC2 MAP2K1 MAP2K2

1.83e-04731025M321
PathwayWP_MAPK_PATHWAY_IN_CONGENITAL_THYROID_CANCER

SHC1 MAP2K1 MAP2K2

1.92e-04161023M39882
PathwayWP_LEPTIN_SIGNALING

SHC1 PLCG1 MAP2K1 MAP2K2 NOS3

2.21e-04761025M39491
PathwaySA_TRKA_RECEPTOR

SHC1 MAP2K1 MAP2K2

2.32e-04171023M18895
PathwayREACTOME_SIGNALING_BY_ALK

SHC1 PTPRZ1 PLCG1

2.32e-04171023MM14790
PathwayREACTOME_RND2_GTPASE_CYCLE

PRAG1 TXNL1 DST WDR6

2.57e-04431024M41827
PathwayREACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE

EFNA1 EFNA3 EPHA10

2.77e-04181023MM15023
PathwayREACTOME_RND2_GTPASE_CYCLE

PRAG1 TXNL1 DST WDR6

2.81e-04441024MM15678
PathwayWP_SEROTONIN_RECEPTOR_467_AND_NR3C_SIGNALING

MAPKAPK2 MAP2K1 MAP2K2

3.28e-04191023M39358
PathwayKEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY

PLCG1 MAP2K1 MAP2K2

3.28e-04191023M47596
PathwayBIOCARTA_EPO_PATHWAY

SHC1 PLCG1 MAP2K1

3.28e-04191023M12836
PathwayWP_RAS_SIGNALING

SHC1 SHC4 SHC2 PLCG1 PLD1 MAP2K1 MAP2K2

3.74e-041841027M39764
PathwayBIOCARTA_EPO_PATHWAY

SHC1 PLCG1 MAP2K1

3.83e-04201023MM1389
PathwayREACTOME_SIGNALLING_TO_RAS

MAPKAPK2 SHC1 SHC2

3.83e-04201023M12256
PathwayWP_SEROTONIN_RECEPTOR_2_AND_ELKSRFGATA4_SIGNALING

MAPKAPK2 MAP2K1 MAP2K2

3.83e-04201023M39485
PathwayBIOCARTA_NGF_PATHWAY

SHC1 PLCG1 MAP2K1

3.83e-04201023M7860
PathwayREACTOME_SIGNALING_BY_NTRKS

MAPKAPK2 SHC1 SHC2 PLCG1 MAP2K1 MAP2K2

4.21e-041341026M3574
PathwayKEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY

SHC1 SHC4 SHC2 PLCG1 MAP2K1 MAP2K2

4.73e-041371026M5669
PathwayKEGG_INSULIN_SIGNALING_PATHWAY

SHC1 SHC4 SHC2 SOCS4 MAP2K1 MAP2K2

4.73e-041371026M18155
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_BRAF_TO_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

5.11e-0451022M49016
PathwayBIOCARTA_NGF_PATHWAY

SHC1 PLCG1 MAP2K1

5.12e-04221023MM1440
PathwayWP_BRAINDERIVED_NEUROTROPHIC_FACTOR_BDNF_SIGNALING

SHC1 SHC4 SHC2 PLCG1 MAP2K1 MAP2K2

6.16e-041441026M39691
PathwayWP_IL1_SIGNALING

MAPKAPK2 PLCG1 MAP2K1 MAP2K2

6.64e-04551024M39346
PathwayPID_IL2_1PATHWAY

MAPKAPK2 SHC1 MAP2K1 MAP2K2

6.64e-04551024M122
PathwayBIOCARTA_TPO_PATHWAY

SHC1 PLCG1 MAP2K1

6.67e-04241023M11520
PathwayBIOCARTA_TPO_PATHWAY

SHC1 PLCG1 MAP2K1

7.53e-04251023MM1519
PathwayPID_SHP2_PATHWAY

SHC1 MAP2K1 MAP2K2 NOS3

7.60e-04571024M100
PathwayREACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY

MAP2K1 MAP2K2

7.63e-0461022M27559
PathwayREACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY

MAP2K1 MAP2K2

7.63e-0461022MM15273
PathwayKEGG_MEDICUS_PATHOGEN_YERSINIA_YOPP_J_TO_TLR2_4_MAPK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

7.63e-0461022M47636
PathwayWP_IL6_SIGNALING_PATHWAY

MAPKAPK2 SHC1 PLCG1 MAP2K1 MAP2K2

7.85e-041001025MM15826
PathwayBIOCARTA_AT1R_PATHWAY

SHC1 MAP2K1 MAP2K2

8.47e-04261023MM1346
PathwayPID_VEGFR1_PATHWAY

SHC2 PLCG1 NOS3

8.47e-04261023M226
PathwayWP_EPO_RECEPTOR_SIGNALING

SHC1 MAP2K1 MAP2K2

8.47e-04261023M39687
PathwayWP_EPO_RECEPTOR_SIGNALING

SHC1 MAP2K1 MAP2K2

8.47e-04261023MM15896
PathwayWP_KIT_RECEPTOR_SIGNALING

SHC1 PLCG1 MAP2K1 MAP2K2

8.66e-04591024M39350
PathwayPID_FCER1_PATHWAY

SHC1 PLCG1 MAP2K1 MAP2K2

9.23e-04601024M7
PathwayBIOCARTA_AT1R_PATHWAY

SHC1 MAP2K1 MAP2K2

9.48e-04271023M14899
PathwayBIOCARTA_ERK_PATHWAY

SHC1 MAP2K1 MAP2K2

9.48e-04271023M287
PathwayBIOCARTA_GH_PATHWAY

SHC1 PLCG1 MAP2K1

9.48e-04271023M9043
PathwayBIOCARTA_EGF_PATHWAY

SHC1 PLCG1 MAP2K1

9.48e-04271023M1909
PathwayBIOCARTA_VEGF_PATHWAY

SHC1 PLCG1 NOS3

9.48e-04271023M12975
PathwayPID_TRKR_PATHWAY

SHC1 SHC2 PLCG1 MAP2K1

9.83e-04611024M187
PathwayBIOCARTA_EGF_PATHWAY

SHC1 PLCG1 MAP2K1

1.06e-03281023MM1386
PathwayBIOCARTA_ERK_PATHWAY

SHC1 MAP2K1 MAP2K2

1.06e-03281023MM1391
PathwayBIOCARTA_PDGF_PATHWAY

SHC1 PLCG1 MAP2K1

1.06e-03281023M2529
PathwayPID_ENDOTHELIN_PATHWAY

TRPC6 GNA12 MAP2K1 MAP2K2

1.11e-03631024M8
PathwayWP_EGFEGFR_SIGNALING

SHC1 PLCG1 PLD1 MAP2K1 MAP2K2 NOS3

1.14e-031621026M39334
PathwayWP_PDGFRBETA_PATHWAY

SHC1 PLCG1 MAP2K1

1.17e-03291023M39616
PathwayREACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE

EFNA1 EFNA3 EPHA10

1.17e-03291023M27309
PathwayBIOCARTA_PDGF_PATHWAY

SHC1 PLCG1 MAP2K1

1.17e-03291023MM1452
PathwayWP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER

ATR MSH6 SMARCD1 MAP2K1 MAP2K2

1.21e-031101025M48043
PathwayREACTOME_SIGNALING_BY_ALK

SHC1 PTPRZ1 PLCG1

1.30e-03301023M42517
PathwayWP_PHYSICOCHEMICAL_FEATURES_AND_TOXICITYASSOCIATED_PATHWAYS

SHC1 FZD8 PLCG1 MAP2K1

1.32e-03661024M39642
PathwayPID_AR_NONGENOMIC_PATHWAY

PLCG1 MAP2K1 MAP2K2

1.43e-03311023M213
PathwayBIOCARTA_BCR_PATHWAY

SHC1 PLCG1 MAP2K1

1.57e-03321023MM1355
PathwayPID_NETRIN_PATHWAY

PLCG1 MAP2K1 MAP2K2

1.57e-03321023M108
PathwayPID_EPO_PATHWAY

TRPC6 SHC1 PLCG1

1.71e-03331023M233
PathwayBIOCARTA_BCR_PATHWAY

SHC1 PLCG1 MAP2K1

1.71e-03331023M9494
PathwayREACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS

RANBP2 XPO1 NUP155

1.71e-03331023M27016
PathwayBIOCARTA_GH_PATHWAY

SHC1 PLCG1 MAP2K1

1.71e-03331023MM1404
PathwayBIOCARTA_INTEGRIN_PATHWAY

SHC1 MAP2K1 MAP2K2

1.71e-03331023MM1426
PathwayWP_ETHANOL_METABOLISM_PRODUCTION_OF_ROS_BY_CYP2E1

MAP2K1 MAP2K2

1.81e-0391022M39481
PathwayBIOCARTA_INTEGRIN_PATHWAY

SHC1 MAP2K1 MAP2K2

1.87e-03341023M3342
PathwayPID_MAPK_TRK_PATHWAY

TRPV1 MAPKAPK2 MAP2K1

1.87e-03341023M270
PathwayREACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS

EFNA1 EFNA3 EPHA10

1.87e-03341023MM15025
PathwayPID_EPHA_FWDPATHWAY

EFNA1 EFNA3 PLCG1

1.87e-03341023M177
PathwayPID_PI3K_PLC_TRK_PATHWAY

TRPV1 SHC1 PLCG1

2.21e-03361023M271
PathwayPID_GMCSF_PATHWAY

SHC1 MAP2K1 MAP2K2

2.21e-03361023M22
PathwayBIOCARTA_MAPK_PATHWAY

MAPKAPK2 SHC1 MAP2K1 MAP2K2

2.22e-03761024MM1433
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

2.25e-03101022M47374
PathwayKEGG_MEDICUS_VARIANT_HRAS_OVEREXPRESSION_TO_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

2.25e-03101022M47420
PathwayWP_ETHANOL_METABOLISM_RESULTING_IN_PRODUCTION_OF_ROS_BY_CYP2E1

MAP2K1 MAP2K2

2.25e-03101022MM15821
Pubmed

Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum.

SHC1 SHC2 MAP2K1 MAP2K2

6.27e-09712949325171
Pubmed

Nerve growth factor signaling, neuroprotection, and neural repair.

MAPKAPK2 SHC1 SHC2 MAP2K1 MAP2K2

4.01e-0826129511520933
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

PCYT1A RANBP2 IPO7 ATR POLA1 SMARCAD1 XPO1 GPKOW CDC45 TXNL1 MSH6 NUP155 UBR5 PSMG1 NCAPD2 SMARCD1 STAG2 MED13

4.20e-0810141291832416067
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPV1 TRPC7 TRPC6 PKD1 MCOLN3

1.42e-0733129519834762
Pubmed

Expression patterns of ShcD and Shc family adaptor proteins during mouse embryonic development.

SHC1 SHC4 SHC2

1.99e-074129321117147
Pubmed

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.

SHC1 SHC4 SLA SHC2 SOCS5 PLCG1

3.22e-0773129624728074
Pubmed

Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.

SHC1 SHC4 SLA SHC2 SOCS5 PLCG1

4.43e-0777129622973453
Pubmed

The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells.

ATR SHC1 SHC2

4.96e-075129310749680
Pubmed

The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor.

SHC1 SHC4 SHC2

4.96e-075129324430869
Pubmed

Angiotensin II type 2 receptor-dependent increase in nitric oxide synthase activity in the endothelium of db/db mice is mediated via a MEK pathway.

MAP2K1 MAP2K2 NOS3

4.96e-075129322465219
Pubmed

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.

TRPV1 TRPC7 TRPC6 PKD1 MCOLN3

6.28e-0744129519322198
Pubmed

Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis.

EFNA1 EFNA3 EPHA10

9.89e-076129315777695
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

RANBP2 IPO7 MYO1D POLA1 COPG2 XPO1 MSH6 DST NUP155 UBR5 WDR6 NCAPD2 STAG2

1.03e-066531291322586326
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

PCYT1A IPO7 CNOT10 MRPL37 COPG2 XPO1 GPKOW CDC45 MSH6 NUP155 WDR6 NCAPD2

1.28e-065601291235241646
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

RANBP2 IPO7 ATR SHC1 COPG2 SMARCAD1 MSH6 OTULIN NUP155 NCAPD2 MAP2K2 STAG2

1.91e-065821291220467437
Pubmed

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.

TRPV1 TRPC7 TRPC6 MCOLN3

2.15e-0625129416382100
Pubmed

Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.

RANBP2 COPG2 XPO1 LRCH1 MSH6 NUP155 UBR5 STON2 NCAPD2 SMARCD1

2.58e-063991291037536630
Pubmed

An introduction to TRP channels.

TRPV1 TRPC7 TRPC6 MCOLN3

2.97e-0627129416460286
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

RANBP2 IPO7 SHC1 XPO1 CDC45 TXNL1 MSH6 SEPSECS MTMR7 MTMR4 NUP155 UBR5 WDR6 PLCG1 ZNF548

3.52e-069741291528675297
Pubmed

Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion.

TRPV1 TRPC7 TRPC6

4.12e-069129317480026
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

RANBP2 IPO7 ATR MYO1D POLA1 SYNE1 MRPL37 SMARCAD1 XPO1 OGDH CDC45 MSH6 NUP155 WDR6 HPRT1 NCAPD2 PLCG1 STAG2

5.62e-0614251291830948266
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

RANBP2 IPO7 MYO1D SHC1 COPG2 XPO1 MSH6 MTMR7 KMT2D MTMR4 NUP155 PTPRZ1 CRLF3 KLHL15 AGTPBP1

8.55e-0610491291527880917
Pubmed

Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.

MAP2K1 MAP2K2

1.37e-05212929563949
Pubmed

Activation of transient receptor potential vanilloid 1 by dietary capsaicin delays the onset of stroke in stroke-prone spontaneously hypertensive rats.

TRPV1 NOS3

1.37e-052129221852608
Pubmed

Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3.

MAPKAPK2 MAP2K2

1.37e-052129224304496
Pubmed

Mek2 is dispensable for mouse growth and development.

MAP2K1 MAP2K2

1.37e-052129212832465
Pubmed

Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity.

HPRT1 PKD1

1.37e-052129223064367
Pubmed

Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors.

MAP2K1 MAP2K2

1.37e-052129219014680
Pubmed

Synergistic cooperation between ABT-263 and MEK1/2 inhibitor: effect on apoptosis and proliferation of acute myeloid leukemia cells.

MAP2K1 MAP2K2

1.37e-052129226625317
Pubmed

Identification of polycystin-1 and Gα12 binding regions necessary for regulation of apoptosis.

PKD1 GNA12

1.37e-052129220837139
Pubmed

Gα12 is required for renal cystogenesis induced by Pkd1 inactivation.

PKD1 GNA12

1.37e-052129227505895
Pubmed

Distinct cellular functions of MK2.

MAPKAPK2 MAP2K2

1.37e-052129212052889
Pubmed

Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation.

MAP2K1 MAP2K2

1.37e-052129221699731
Pubmed

Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia.

MAP2K1 MAP2K2

1.37e-052129217419998
Pubmed

MEK1 and MEK2 differentially control the duration and amplitude of the ERK cascade response.

MAP2K1 MAP2K2

1.37e-052129223735655
Pubmed

TRPC6 Deletion Enhances eNOS Expression and Reduces LPS-Induced Acute Lung Injury.

TRPC6 NOS3

1.37e-052129238069081
Pubmed

The Predictive Value of MAP2K1/2 Mutations on Efficiency of Immunotherapy in Melanoma.

MAP2K1 MAP2K2

1.37e-052129235069558
Pubmed

Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry.

XPO1 AGTPBP1

1.37e-052129223242554
Pubmed

The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility.

MAP2K1 MAP2K2

1.37e-052129221527500
Pubmed

Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia.

MAP2K1 MAP2K2

1.37e-052129219383924
Pubmed

Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1.

TRPV1 NOS3

1.37e-052129221493704
Pubmed

MEK1 and MEK2, different regulators of the G1/S transition.

MAP2K1 MAP2K2

1.37e-052129215284233
Pubmed

Spectrum of MEK1 and MEK2 gene mutations in cardio-facio-cutaneous syndrome and genotype-phenotype correlations.

MAP2K1 MAP2K2

1.37e-052129219156172
Pubmed

The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.

SOCS5 SOCS4

1.37e-052129222423360
Pubmed

Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin-dependent kinase II.

TRPC7 TRPC6

1.37e-052129223529130
Pubmed

p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2.

MAP2K1 MAP2K2

1.37e-052129212839928
Pubmed

Ephrin-A1 is up-regulated by hypoxia in cancer cells and promotes angiogenesis of HUVECs through a coordinated cross-talk with eNOS.

EFNA1 NOS3

1.37e-052129224040255
Pubmed

MEK1/2 inhibition promotes Taxotere lethality in mammary tumors in vivo.

MAP2K1 MAP2K2

1.37e-052129216957420
Pubmed

T cell adhesion primes antigen receptor-induced calcium responses through a transient rise in adenosine 3',5'-cyclic monophosphate.

MAP2K1 MAP2K2

1.37e-052129219144315
Pubmed

Distinct genetic alterations in the mitogen-activated protein kinase pathway dictate sensitivity of thyroid cancer cells to mitogen-activated protein kinase kinase 1/2 inhibition.

MAP2K1 MAP2K2

1.37e-052129219500021
Pubmed

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.

MAP2K1 MAP2K2

1.37e-052129222197931
Pubmed

PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels.

TRPC7 TRPC6

1.37e-052129224470487
Pubmed

Allosteric MEK1/2 inhibitors including cobimetanib and trametinib in the treatment of cutaneous melanomas.

MAP2K1 MAP2K2

1.37e-052129227956260
Pubmed

Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options.

MAP2K1 MAP2K2

1.37e-052129217981815
Pubmed

Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells.

MAP2K1 MAP2K2

1.37e-052129228746311
Pubmed

Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases.

MAP2K1 MAP2K2

1.37e-052129230087384
Pubmed

Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity.

MAP2K1 MAP2K2

1.37e-052129222833572
Pubmed

ERK1/2 can feedback-regulate cellular MEK1/2 levels.

MAP2K1 MAP2K2

1.37e-052129226163823
Pubmed

Omics profiling identifies the regulatory functions of the MAPK/ERK pathway in nephron progenitor metabolism.

MAP2K1 MAP2K2

1.37e-052129236189831
Pubmed

Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial.

MAP2K1 MAP2K2

1.37e-052129222805292
Pubmed

Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial.

MAP2K1 MAP2K2

1.37e-052129222805291
Pubmed

MAPK-activated protein kinase 2 differentially regulates plasmodium falciparum glycosylphosphatidylinositol-induced production of tumor necrosis factor-{alpha} and interleukin-12 in macrophages.

MAPKAPK2 MAP2K2

1.37e-052129219359247
Pubmed

Biphasic regulation of osteoblast development via the ERK MAPK-mTOR pathway.

MAP2K1 MAP2K2

1.37e-052129235975983
Pubmed

Inhibitors of the mitogen-activated protein kinase kinase 1/2 signaling pathway clear prion-infected cells from PrPSc.

MAP2K1 MAP2K2

1.37e-052129216162927
Pubmed

Importin 7 and Nup358 promote nuclear import of the protein component of human telomerase.

RANBP2 IPO7

1.37e-052129224586428
Pubmed

Regulation of intracellular MEK1/2 translocation in mouse oocytes: cytoplasmic dynein/dynactin-mediated poleward transport and cyclin B degradation-dependent release from spindle poles.

MAP2K1 MAP2K2

1.37e-052129217507801
Pubmed

Activation of two isoforms of mitogen-activated protein kinase kinase in response to epidermal growth factor and nerve growth factor.

MAP2K1 MAP2K2

1.37e-05212928529659
Pubmed

Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product.

MAP2K1 MAP2K2

1.37e-05212921381507
Pubmed

[Mek1 and Mek2 functions in the formation of the blood placental barrier].

MAP2K1 MAP2K2

1.37e-052129222549869
Pubmed

The ERK1/2 pathway regulates testosterone synthesis by coordinately regulating the expression of steroidogenic genes in Leydig cells.

MAP2K1 MAP2K2

1.37e-052129223480967
Pubmed

MK2 signaling: lessons on tissue specificity in modulation of inflammation.

MAPKAPK2 MAP2K2

1.37e-052129220081887
Pubmed

Identification and characterization of a novel chemotype MEK inhibitor able to alter the phosphorylation state of MEK1/2.

MAP2K1 MAP2K2

1.37e-052129223237773
Pubmed

Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis.

IPO7 XPO1

1.37e-052129222284678
Pubmed

Cisplatin inhibits MEK1/2.

MAP2K1 MAP2K2

1.37e-052129226155939
Pubmed

Mek1/2 gene dosage determines tissue response to oncogenic Ras signaling in the skin.

MAP2K1 MAP2K2

1.37e-052129219198628
Pubmed

Characterization of the proline-rich region of mouse MAPKAP kinase 2: influence on catalytic properties and binding to the c-abl SH3 domain in vitro.

MAPKAPK2 MAP2K2

1.37e-05212928093038
Pubmed

Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo.

MAP2K1 MAP2K2

1.37e-052129215979847
Pubmed

WDR87 interacts with CFAP47 protein in the middle piece of spermatozoa flagella to participate in sperm tail assembly.

CFAP47 WDR87

1.37e-052129236571501
Pubmed

ERK (MAPK) does not phosphorylate tau under physiological conditions in vivo or in vitro.

MAP2K1 MAP2K2

1.37e-052129225491074
Pubmed

Distinct effects of knocking down MEK1 and MEK2 on replication of herpes simplex virus type 2.

MAP2K1 MAP2K2

1.37e-052129220172001
Pubmed

Chromosome mapping of the human genes encoding the MAP kinase kinase MEK1 (MAP2K1) to 15q21 and MEK2 (MAP2K2) to 7q32.

MAP2K1 MAP2K2

1.37e-052129210828601
Pubmed

Implication of MEK1 and MEK2 in the establishment of the blood-placenta barrier during placentogenesis in mouse.

MAP2K1 MAP2K2

1.37e-052129222561024
Pubmed

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.

MAP2K1 MAP2K2

1.37e-052129215543157
Pubmed

Somatic mutations in KMT2D and TET2 associated with worse prognosis in Epstein-Barr virus-associated T or natural killer-cell lymphoproliferative disorders.

TET2 KMT2D

1.37e-052129231311407
Pubmed

Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.

MAP2K1 MAP2K2

1.37e-052129218390968
Pubmed

Importin-β and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function.

RANBP2 XPO1

1.37e-052129228600321
Pubmed

Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

SHC1 SOCS5 SOCS4

1.39e-0513129323990909
Pubmed

Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.

IPO7 MYO1D COPG2 XPO1 MSH6 KCTD5 WDR6 HPRT1 MAP2K1

1.39e-05383129929331416
Pubmed

Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.

ATR COPG2 XPO1 MSH6 UBR5

1.88e-0587129517148452
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

SMG1 THSD7A SYNE1 LRCH1 DST ALMS1 UBR5

2.21e-05225129712168954
Pubmed

Aire's partners in the molecular control of immunological tolerance.

RANBP2 IPO7 XPO1 MSH6

2.39e-0545129420085707
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

RANBP2 IPO7 SMARCAD1 MSH6 UBR5 SMARCD1

2.39e-05153129626365490
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

SMG1 IPO7 MYO1D MRPL37 GPKOW PLEKHH1 RAD51AP2 KMT2D SMARCD1 MAP2K2 STAG2

2.74e-056381291131182584
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TET2 RANBP2 COPG2 TXNL1 KMT2D DST ALMS1 UBR5 WDR6

2.76e-05418129934709266
Pubmed

TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6.

EFNA1 EFNA3 PLCG1 PLXNB1

2.85e-0547129435462405
Pubmed

The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.

RANBP2 XPO1 MSH6 NUP155 WDR6 NCAPD2 PLCG1

3.08e-05237129729564676
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

MYO1D SYNE1 DST NUP155 SACS

3.87e-0510112959872452
Pubmed

Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation.

MAPKAPK2 MAP2K1 MAP2K2

3.91e-0518129321675959
Pubmed

Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector.

MAP2K1 MAP2K2

4.09e-053129210489373
Pubmed

The mouse dystonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1.

EFNA1 DST

4.09e-05312927670468
InteractionGAREM1 interactions

SHC1 SHC4 XPO1 EFNA1 PLCG1

5.66e-07271235int:GAREM1
Cytoband17q22-q23

MTMR4 MED13

1.17e-046129217q22-q23
GeneFamilySH2 domain containing

SHC1 SHC4 SLA SHC2 SOCS5 SOCS4 PLCG1

4.38e-07101847741
GeneFamilyTransient receptor potential cation channels

TRPV1 TRPC7 TRPC6 MCOLN3

8.15e-0628844249
GeneFamilyMitogen-activated protein kinase kinases

MAP2K1 MAP2K2

4.41e-047842653
GeneFamilyEphrins

EFNA1 EFNA3

5.86e-048842546
GeneFamilySH2 domain containing|Suppressors of cytokine signaling

SOCS5 SOCS4

5.86e-048842764
GeneFamilyMyotubularins|Phosphoinositide phosphatases

MTMR7 MTMR4

2.15e-0315842903
CoexpressionGSE27786_BCELL_VS_NKTCELL_UP

MMS22L LRCH1 CCNF RSBN1 MSH6 BST1 MED13 AGTPBP1

6.16e-062001278M4808
CoexpressionHE_LIM_SUN_FETAL_LUNG_C5_LARGE_PRE_B_CELL

MMS22L REXO5 IPO7 DCPS POLA1 CNOT10 TTC39C COPG2 XPO1 CDC45 CCNF TRMU MSH6 OTULIN NUP155 PSMG1 HPRT1 NCAPD2 SMARCD1 MAP2K2

8.97e-06136312720M45782
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

TET2 SMG1 CHDH TBCK NCAPD2 SMARCD1 MED13

2.86e-051801277M8239
CoexpressionHE_LIM_SUN_FETAL_LUNG_C4_CYCLING_T_CELL

MMS22L POLA1 CNOT10 BACH2 XPO1 NEMP2 CDC45 CCNF MSH6 NUP155 ALMS1 WDR6 PSMG1 NCAPD2 MED13

5.11e-0593912715M45768
CoexpressionGSE14308_TH1_VS_TH17_DN

SMG1 ZNF560 LRCH1 KMT2D UBR5 CRLF3 PKD1

5.59e-052001277M3374
CoexpressionGSE17721_CTRL_VS_GARDIQUIMOD_8H_BMDC_DN

RANBP2 MAPKAPK2 TTC39C KCNE1 CRLF3 PLCG1 OSGIN2

5.59e-052001277M3790
CoexpressionGSE6259_DEC205_POS_DC_VS_CD4_TCELL_DN

MRPL37 NUP155 SACS PKD1 PLCG1 PLD1 MAP2K2

5.59e-052001277M6774
CoexpressionABRAMSON_INTERACT_WITH_AIRE

RANBP2 IPO7 XPO1 MSH6

6.14e-05441274M2536
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

RANBP2 IPO7 ATR XPO1 RSBN1 MSH6 DST SACS UBR5 SOCS5 UGCG MAP2K1 STAG2 MED13

7.19e-0585612714M4500
CoexpressionAtlasdev gonad_e11.5_F_PrimGermCell_Oct_k-means-cluster#3_top-relative-expression-ranked_1000

MMS22L POLA1 PIWIL2 CDC45 CCNF MSH6 MTMR7 UBR5 CRLF3 NCAPD2 OSGIN2 PRMT7

1.76e-0546312412gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_k3_1000
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

MMS22L POLA1 XPO1 CDC45 CCNF CRLF3 NCAPD2

1.39e-061901297d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCellSepsis-Int-URO-Lymphocyte-T/NK-dn_T|Int-URO / Disease, condition lineage and cell class

POLA1 MRPL37 LRCH1 UBR5 TBCK GNA12 DTHD1

1.95e-062001297020439d9e70fff7246650ab0e9105236688c3ec3
ToppCellfacs|World / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IPO7 CYP20A1 COPG2 EFNA3 GNA12 PLCG1

1.10e-051721296a2d0a64ebf09d219a07d6bbad1056bad6d46b9be
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

COPG2 CDC45 CCNF SACS KLHL15 AGTPBP1

1.14e-05173129620889aa85e36ad3bafdb91b91e43964493c949f9
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

COPG2 CDC45 CCNF SACS KLHL15 AGTPBP1

1.14e-05173129646e601b7938b1dd0aa3df7aa056c4bd07b1620c1
ToppCellCV-Severe-7|Severe / Virus stimulation, Condition and Cluster

SMG1 MMS22L CDC45 DST UBR5 TBCK

1.30e-05177129682fdd6185b368f54f03de389427cbe3071d21a99
ToppCelldroplet-Heart-nan-3m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHLD2 COL16A1 CYP20A1 PTPRZ1 TBCK PLXNB1

1.43e-051801296da723df348d7b8449bb1124f23fe6fa706412adb
ToppCelldroplet-Heart-nan-3m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHLD2 COL16A1 CYP20A1 PTPRZ1 TBCK PLXNB1

1.43e-0518012965b146a94708b3c3610542a4d0925f3f7a2b19185
ToppCelldroplet-Heart-nan-3m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHLD2 COL16A1 CYP20A1 PTPRZ1 TBCK PLXNB1

1.43e-05180129650758b1e7be2e43f83c10ab106900c067e61f5f7
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

MMS22L XPO1 KMT2D NUP155 KLHL15 AGTPBP1

1.67e-051851296a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

MMS22L XPO1 MSH6 NUP155 KLHL15 AGTPBP1

1.72e-0518612968571956890fc9894d766ba294a28e376b4aba428
ToppCelldroplet-Fat-SCAT-30m-Epithelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IPO7 POLA1 CHDH PKD1 STON2 PLXNB1

1.77e-0518712965fada3c5a58c1890029ccbfff2608b33f8cd2df7
ToppCelldroplet-Fat-SCAT-30m-Epithelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IPO7 POLA1 CHDH PKD1 STON2 PLXNB1

1.77e-051871296766e808138fc2cd623c2e6d57fcb5c7378da0e03
ToppCelldroplet-Fat-SCAT-30m-Epithelial-epithelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IPO7 POLA1 CHDH PKD1 STON2 PLXNB1

1.77e-051871296f49d06600060deeb2fc1b1da5b93496535f20104
ToppCellIPF-Epithelial-Basal|Epithelial / Disease state, Lineage and Cell class

BACH2 TRPC6 LRCH1 DST PTPRZ1 STON2

1.94e-0519012964f15842b424eefadbfe451875e517cf70e29607f
ToppCell10x3'2.3-week_14-16-Myeloid_DC-DC-pDC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

DCPS MAPKAPK2 SLC12A3 KCTD5 UGCG STAMBPL1

2.12e-0519312962c35aadc397e7e365c3daf8017ae1d3bd045f305
ToppCellPSB-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CFAP47 SYNE1 KCNE1 TEKT1 CFAP57 DTHD1

2.38e-0519712966865f4831eb23794fb88a8649d48d497bbae3f44
ToppCellNS-moderate-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CFAP47 SYNE1 KCNE1 TEKT1 CFAP57 DTHD1

2.38e-05197129671fea4aa6ce96c7693fa94792d08770622873850
ComputationalNucleotide metabolism.

POLA1 CDC45 NUP155 ALMS1 HPRT1 NCAPD2

5.98e-0664776MODULE_337
ComputationalNuclear pore complex.

RANBP2 IPO7 XPO1

2.24e-0417773MODULE_352
Diseasegastric adenocarcinoma (is_implicated_in)

XPO1 KMT2D UBR5

1.11e-05111223DOID:3717 (is_implicated_in)
Diseasesmall intestine adenocarcinoma (is_implicated_in)

MAP2K1 MAP2K2

5.07e-0531222DOID:4906 (is_implicated_in)
Diseaseperitonsillar abscess

TET2 PRAG1 GNA12

5.38e-05181223EFO_0007429
Diseasefamilial hyperlipidemia (biomarker_via_orthology)

SHC1 SMARCD1 NOS3

6.37e-05191223DOID:1168 (biomarker_via_orthology)
DiseaseInfiltrating duct carcinoma of female breast

SMG1 ATR EPHA10

8.69e-05211223C3165106
Diseasebreast cancer (is_marker_for)

TET2 AKR1A1 KMT2D PLCG1 MAP2K1 MAP2K2

1.24e-041851226DOID:1612 (is_marker_for)
DiseaseSezary Syndrome

TET2 KMT2D PLCG1

1.88e-04271223C0036920
Diseasecorpus callosum mid-anterior volume measurement

TTC39C SLA SEPSECS

1.88e-04271223EFO_0010297
DiseaseNeoplasm of uncertain or unknown behavior of ovary

ATR MSH6 MAP2K1

2.33e-04291223C0496920
DiseaseOvarian Carcinoma

ATR MSH6 MAP2K1

2.58e-04301223C0029925
Diseasefacial emotion recognition measurement

THSD7A MYO1D FAR2

4.10e-04351223EFO_0008329
Diseaselung adenocarcinoma (is_marker_for)

AKR1A1 XPO1 PLCG1 MAP2K1

4.35e-04851224DOID:3910 (is_marker_for)
Diseasecentronuclear myopathy X-linked (implicated_via_orthology)

MTMR7 MTMR4

5.99e-0491222DOID:0111225 (implicated_via_orthology)
DiseaseRASopathy (implicated_via_orthology)

MAP2K1 MAP2K2

5.99e-0491222DOID:0080690 (implicated_via_orthology)
Diseasemigraine (is_implicated_in)

TRPV1 NOS3

5.99e-0491222DOID:6364 (is_implicated_in)
DiseaseCutaneous Melanoma

MAP2K1 MAP2K2 STAG2

6.55e-04411223C0151779
DiseaseAdenocarcinoma of large intestine

MSH6 UBR5 TBCK MAP2K1

6.89e-04961224C1319315
Diseaserenal cell carcinoma

MYO7B PLD1 MAP2K1

7.04e-04421223EFO_0000681
DiseaseWNT1-inducible-signaling pathway protein 1 measurement

SLA SEPSECS

7.47e-04101222EFO_0008321
Diseasecorpus callosum volume measurement

TTC39C XPO1 SLA SEPSECS

8.03e-041001224EFO_0010299
DiseaseNoonan Syndrome 1

MAP2K1 MAP2K2

9.10e-04111222C4551602
DiseaseTurner Syndrome, Male

MAP2K1 MAP2K2

9.10e-04111222C0041409
DiseaseFemale Pseudo-Turner Syndrome

MAP2K1 MAP2K2

9.10e-04111222C1527404
Diseasecesarean section, intelligence

C6orf89 BACH2

1.09e-03121222EFO_0004337, EFO_0009636
Diseasenicotine dependence (implicated_via_orthology)

TRPC7 TRPC6

1.09e-03121222DOID:0050742 (implicated_via_orthology)
Diseaseintracranial aneurysm (is_implicated_in)

KMT2D PKD1

1.09e-03121222DOID:10941 (is_implicated_in)
DiseaseTourette syndrome

THSD7A EFNA1 CD276

1.17e-03501223EFO_0004895
Diseaseeosinophil count

TET2 DCPS ATR C6orf89 BACH2 SHC1 XPO1 SLA SEPSECS WDR6 PDE8B GNA12 PLD1 MAP2K2 EPHA10

1.25e-03148812215EFO_0004842
DiseaseLiver Cirrhosis, Experimental

TRPV1 RDH10 SLA PLEKHH1 FZD8 MTMR7 GPR68 UGCG NOS3 CD276

1.43e-0377412210C0023893
DiseasePneumoconiosis

ATR PTPRZ1

1.49e-03141222C0032273
DiseaseBagassosis

ATR PTPRZ1

1.49e-03141222C0004681
DiseaseMalignant Neoplasms

TRPV1 ATR MAP2K1 NOS3

2.00e-031281224C0006826
DiseaseBenign neoplasm of stomach

ATR UBR5

2.21e-03171222C0153943
DiseaseVitiligo

BACH2 SLA

2.21e-03171222C0042900
DiseaseNeoplasm of uncertain or unknown behavior of stomach

ATR UBR5

2.21e-03171222C0496905
DiseaseNecrotizing Enterocolitis

AKR1A1 NOS3

2.21e-03171222C0520459
DiseaseCarcinoma in situ of stomach

ATR UBR5

2.21e-03171222C0154060
Diseaseoral squamous cell carcinoma (is_marker_for)

TET2 KMT2D PLCG1

2.29e-03631223DOID:0050866 (is_marker_for)
Diseaseessential hypertension (is_implicated_in)

SLC12A3 NOS3

2.48e-03181222DOID:10825 (is_implicated_in)
DiseaseMalignant neoplasm of endometrium

ATR MSH6

2.48e-03181222C0007103
DiseaseCarcinoma in situ of endometrium

ATR MSH6

2.48e-03181222C0346191
Diseasebreast carcinoma (is_marker_for)

MSH6 KMT2D PLCG1

2.61e-03661223DOID:3459 (is_marker_for)
Diseaselung non-small cell carcinoma (is_implicated_in)

TET2 XPO1 KMT2D PLCG1

2.70e-031391224DOID:3908 (is_implicated_in)
DiseaseBladder Neoplasm

TRPV1 GSTO2 KMT2D STAG2

2.77e-031401224C0005695
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

MAP2K1 MAP2K2

2.77e-03191222C3501846
DiseaseNoonan syndrome-like disorder with loose anagen hair

MAP2K1 MAP2K2

2.77e-03191222C1843181
DiseaseCardio-facio-cutaneous syndrome

MAP2K1 MAP2K2

2.77e-03191222C1275081
DiseaseCostello syndrome (disorder)

MAP2K1 MAP2K2

2.77e-03191222C0587248
DiseaseMalignant neoplasm of urinary bladder

TRPV1 GSTO2 KMT2D STAG2

2.84e-031411224C0005684
Diseasestomach cancer (is_marker_for)

TET2 XPO1 KMT2D UBR5

2.91e-031421224DOID:10534 (is_marker_for)
DiseaseStomach Carcinoma

ATR UBR5

3.38e-03211222C0699791
Diseaseesophagus squamous cell carcinoma (is_marker_for)

TET2 XPO1 KMT2D

3.61e-03741223DOID:3748 (is_marker_for)
DiseaseLEOPARD Syndrome

MAP2K1 MAP2K2

3.71e-03221222C0175704
DiseaseATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)

NUP155 KCNE1

3.71e-03221222C1843687
Diseaseunipolar depression, bipolar disorder, schizophrenia, sex interaction measurement

C6orf89 SHC4 GNA12

3.89e-03761223EFO_0003761, EFO_0008343, MONDO_0004985, MONDO_0005090
DiseaseRenal glomerular disease

TRPC6 SLC12A3

4.05e-03231222C0268731
DiseaseGlomerulopathy Assessment

TRPC6 SLC12A3

4.05e-03231222C4521256

Protein segments in the cluster

PeptideGeneStartEntry
NDYRPVKLLQCVDHS

BST1

261

Q10588
DIQSPEQIQALHRYC

BACH2

716

Q9BYV9
PAVQYCNLARDLHLE

ARHGEF37

316

A1IGU5
DLQQVHIYCDPELVL

COL16A1

221

Q07092
CPAQVELQSLYVDVH

FCRL4

441

Q96PJ5
YDKENRTPLIQAVHC

ANKRD20A5P

96

A0PJZ0
QRELFEQCKAPYVDH

ALMS1

2926

Q8TCU4
YSCLVRNPVLQQDAH

CD276

436

Q5ZPR3
HNPQQIYFRKDVLCE

AGTPBP1

866

Q9UPW5
VIENLECDPRHYQQR

DCPS

301

Q96C86
DHLEIYIQQACTRPI

CHDH

336

Q8NE62
IIRELQVLHECNSPY

MAP2K1

111

Q02750
IRELQVLHECNSPYI

MAP2K2

116

P36507
HIFEDLCNVRQQAIP

RAD51AP2

781

Q09MP3
EIHPEICRLYIQLQC

RGS7BP

116

Q6MZT1
REQVLKICANHYISP

RANBP2

1236

P49792
NVIDHYLCDVLPLLQ

OR8B4

171

Q96RC9
VCPNVHEKIRAIYAD

FAR2

71

Q96K12
HRDCAQYLREVAQPV

ESPNL

316

Q6ZVH7
EICYTAVVVPHILAN

OR10W1

61

Q8NGF6
ASQCPHIVRIVDVYE

MAPKAPK2

111

P49137
NLQTVRHQELPDCYD

MCOLN3

226

Q8TDD5
DAYRVCQILDIPFHQ

TRMU

56

O75648
QLIIPQERDCHDVYI

MTMR7

81

Q9Y216
VPQLFYCLHEIREEA

NLRP8

606

Q86W28
DDIICPQVVARYLSH

MMS22L

776

Q6ZRQ5
AGYILECENLLRQHV

DST

431

Q03001
DLHNCVAYIQEPRLL

CFAP57

1056

Q96MR6
EEHCLNPENTERIYQ

FSIP2

6406

Q5CZC0
VQHCRYVDEVVRNAP

PCYT1A

136

P49585
PCLTKHVLRENQDYV

PLXNB1

1851

O43157
YTIPEEDRHCIRENI

IPO7

81

O95373
ACYNELIQIEHGEVR

PDE8B

246

O95263
RIVYIAERHNCQYPE

NEMP2

81

A6NFY4
VLHIDPNVDYQFRVC

CRLF3

236

Q8IUI8
LAACREHQRAPEVYV

EEF2KMT

266

Q96G04
HIPVLETSQCQLIYE

GSTO2

71

Q9H4Y5
NLYHNCIRVIPEAIV

LRCH1

126

Q9Y2L9
PRENQVVELHYDAIC

GPKOW

451

Q92917
EHDRPIRTYQVCNVL

EPHA10

66

Q5JZY3
QDDYVLEVRHFQCPK

PTPRZ1

2176

P23471
PLCNHYAINDRLDAI

MSH6

781

P52701
PIIDLHECNIYDVKN

MRPL37

261

Q9BZE1
YLAQQIHPVVARICE

POLA1

1211

P09884
DPVLVCNSCYEHIQV

MTMR4

1161

Q9NYA4
CIHVLLIRYVENPSQ

NUP155

1326

O75694
LFCIPNHYAEDLERV

HPRT1

21

P00492
NLCDPHRYNILEDVA

NOS3

366

P29474
IVHDLPAAVLSYCQV

PSMG1

211

O95456
VVVDLVCYRRNGHNE

OGDH

501

Q02218
DDRHYNIPVRVCEET

OTULIN

336

Q96BN8
AVLCAYNSNIPVIHV

OSGIN2

316

Q9Y236
VVVACLFYEQHNRPR

FZD8

546

Q9H461
CYDRAIQLEPDQIIH

ATR

1721

Q13535
FVCDTHRPVNVVNVY

CDC45

96

O75419
QVCNLHFPDYVLDEV

KLHL15

586

Q96M94
VQVNVNDYLDIYCPH

EFNA3

51

P52797
LDVTVVYLNPEQHCC

CCNF

636

P41002
LVEHEEYQLCQPQSK

EFNA1

71

P20827
CEAVPHRATVYAQLV

PRMT7

171

Q9NVM4
RAVYAPQNIYCVHVD

GCNT3

151

O95395
PHRLEDVQRYLVQCF

GNA12

321

Q03113
QEALLPVVDYEHCSR

CELA3B

176

P08861
YEVLLCVQDHDDPAI

UGCG

81

Q16739
VIYEAASAIIHLPNC

COPG2

266

Q9UBF2
PSYVLQQLECRIINH

DTHD1

191

Q6ZMT9
QVPVKHVYRVLQCQE

KCTD5

151

Q9NXV2
CYVVENHLAIEQPNT

KCNE1

106

P15382
TPEKIEQLRYCQHVL

CYP20A1

316

Q6UW02
LEEEIQHFLCQYPEA

C6orf89

191

Q6UWU4
YTAEHQDIVCLLQPI

SACS

2246

Q9NZJ4
PEEYLHNCLIIVNTL

CFAP47

1821

Q6ZTR5
PEATVEHVYLRAQNC

PKD1

1256

P98161
AIDRLVAICNPLHYD

OR1L6

156

Q8NGR2
ENQHRVCFEHYPIQA

GPR68

166

Q15743
PRLTFQCLEDLVNHY

SLA

146

Q13239
CDNDIYFIPRNVIHQ

RSBN1

671

Q5VWQ0
ANVVILHDIDCNPYN

SMARCAD1

941

Q9H4L7
TQIDYIHCLVPDLLQ

SOCS5

361

O75159
PHEREFVICDKYLQQ

SMARCD1

331

Q96GM5
LDHVNQAQVYEVVPC

THSD7A

1076

Q9UPZ6
LQSVLEEIHCYEPQL

SYNE1

3216

Q8NF91
VFRCLPNDEVHNLIQ

PLD1

1001

Q13393
EVNHCLPEKIVVYRD

PIWIL2

801

Q8TC59
NHPEVYVRQSICNLL

SMG1

1831

Q96Q15
TQIDYVHCLVPDLLQ

SOCS4

266

Q8WXH5
RECVPTEYHEIQNQC

SHLD2

196

Q86V20
VIRCNLAPVQEYARD

ST8SIA2

181

Q92186
THRPNVELCRDVAQY

TEKT1

321

Q969V4
QRDIAYVVLCPENEA

MED13

1366

Q9UHV7
NPIIYCLRNHEVKAA

OR6Y1

291

Q8NGX8
EEEILPHCNLQVFTY

RDH10

101

Q8IZV5
LEICHEISEPRLQNY

STON2

476

Q8WXE9
AVLQVECHPYLAQNE

AKR1A1

181

P14550
PQDYRLAQQVCHAIA

NCAPD2

806

Q15021
ECLIEAVQVYHANPR

CNOT10

376

Q9H9A5
YVAKDPVNQRACHIL

SHC4

306

Q6S5L8
IICDLQPQQVHTFYE

XPO1

621

O14980
YVAKDPINQRACHIL

SHC2

266

P98077
AYILQREIQEPECRH

TRPV1

351

Q8NER1
QFETNDQCRPYHRIL

SLC26A2

41

P50443
PEQIVIHALQCTHYV

STAG2

726

Q8N3U4
FVLETRQPHLCIQYE

REXO5

536

Q96IC2
RQPHLCIQYEVLEAA

REXO5

541

Q96IC2
VEKLPNHRDYQQCAV

STAMBPL1

86

Q96FJ0
HVYCVDNILVRLADP

UAP1L1

251

Q3KQV9
AFVCDIRPEIHENYR

ATP6V1G1

101

O75348
ITHYQQVPLRCNEFE

PLCG1

636

P19174
LNEVEDHIKNYRPQC

SLC12A3

631

P55017
TDRQIEVDIPRCHQY

TBCK

501

Q8TEA7
QEVILRCVPISNHLY

TRBV2

36

A0A1B0GX68
QLRVLEEYSVPCAHA

WDR6

1031

Q9NNW5
HQAEPEAYERRVCFL

PRAG1

1111

Q86YV5
VCLVHPELQSEIYCQ

PLEKHH1

886

Q9ULM0
AEVPIIDRQACEQLY

PRSS48

171

Q7RTY5
IYICEAELFQHPKQQ

ZNF548

111

Q8NEK5
EELAVICANYDIPHI

SEPSECS

236

Q9HD40
TPIILAAHCQEYEIV

TRPC6

221

Q9Y210
VDQREIQHVCLYEIG

TTC39C

346

Q8N584
NNQIEYEHRAPECRL

TET2

1346

Q6N021
IYLQCNLHAPQRELE

WDR87

801

Q6ZQQ6
YVAKDPVNQRACHIL

SHC1

276

P29353
AVNVETHIIKNPYEC

ZNF560

336

Q96MR9
QTVARQTVEHCQYRP

UBR5

1281

O95071
TPIILAAHCQEYEIV

TRPC7

166

Q9HCX4
EPFVLHVQCRQLQDA

TYW3

101

Q6IPR3
YPQAVFLEVDVHQCQ

TXNL1

51

O43396
HAPYVEEDLLIQCRH

KMT2D

1511

O14686
CRHQVEYLGLLENVR

MYO1D

606

O94832
RVCRQAPEERNYHIF

MYO7B

241

Q6PIF6
LQHPALQDEVYCQIL

MYO7B

1701

Q6PIF6