Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCA4 CFTR ABCC2 ABCA10	9.25e-06	49	54	4	GO:0140359
GeneOntologyMolecularFunction	glycine N-acyltransferase activity	GLYAT GLYATL2	7.14e-05	5	54	2	GO:0047961
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	CFTR HCN3 AQP1	9.63e-05	33	54	3	GO:0005217
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCA4 CFTR ABCC2 ABCA10	2.15e-04	109	54	4	GO:0042626
GeneOntologyMolecularFunction	ATPase-coupled inorganic anion transmembrane transporter activity	CFTR ABCC2	3.19e-04	10	54	2	GO:0043225
GeneOntologyMolecularFunction	intracellularly cyclic nucleotide-activated monoatomic cation channel activity	HCN3 AQP1	5.49e-04	13	54	2	GO:0005221
GeneOntologyMolecularFunction	cyclic nucleotide-activated monoatomic ion channel activity	HCN3 AQP1	5.49e-04	13	54	2	GO:0043855
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ABCA4 CFTR ABCC2 ABCA10	1.36e-03	178	54	4	GO:0015399
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	CFTR HCN3 NMUR2 AQP1	1.83e-03	193	54	4	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	CFTR HCN3 NMUR2 AQP1	1.98e-03	197	54	4	GO:0022834
GeneOntologyMolecularFunction	gated channel activity	CFTR HCN3 TMC8 NMUR2 AQP1	2.05e-03	334	54	5	GO:0022836
GeneOntologyMolecularFunction	lysine-acetylated histone binding	PSME4 ZZEF1	2.97e-03	30	54	2	GO:0070577
GeneOntologyMolecularFunction	acetylation-dependent protein binding	PSME4 ZZEF1	3.17e-03	31	54	2	GO:0140033
GeneOntologyBiologicalProcess	cellular response to cAMP	CFTR HCN3 EEF2K AQP1	1.04e-05	53	53	4	GO:0071320
GeneOntologyBiologicalProcess	transepithelial water transport	CFTR AQP1	3.87e-05	4	53	2	GO:0035377
Domain	ABC_transporter_CS	ABCA4 CFTR ABCC2 ABCA10	5.53e-06	42	52	4	IPR017871
Domain	ABC_tran	ABCA4 CFTR ABCC2 ABCA10	9.49e-06	48	52	4	PF00005
Domain	ABC_TRANSPORTER_2	ABCA4 CFTR ABCC2 ABCA10	9.49e-06	48	52	4	PS50893
Domain	ABC_TRANSPORTER_1	ABCA4 CFTR ABCC2 ABCA10	1.03e-05	49	52	4	PS00211
Domain	ABC_transporter-like	ABCA4 CFTR ABCC2 ABCA10	1.12e-05	50	52	4	IPR003439
Domain	Glycine_N-acyltransferase_C	GLYAT GLYATL2	4.55e-05	4	52	2	IPR013652
Domain	Glycine_N-acyltransferase_N	GLYAT GLYATL2	4.55e-05	4	52	2	IPR015938
Domain	Gly_acyl_tr_C	GLYAT GLYATL2	4.55e-05	4	52	2	PF08444
Domain	Gly_acyl_tr_N	GLYAT GLYATL2	4.55e-05	4	52	2	PF06021
Domain	Glycine_N-acyltransferase	GLYAT GLYATL2	4.55e-05	4	52	2	IPR010313
Domain	ABC_A	ABCA4 ABCA10	4.93e-04	12	52	2	IPR026082
Domain	AAA+_ATPase	ABCA4 CFTR ABCC2 ABCA10	6.88e-04	144	52	4	IPR003593
Domain	AAA	ABCA4 CFTR ABCC2 ABCA10	6.88e-04	144	52	4	SM00382
Domain	ABC_membrane	CFTR ABCC2	2.02e-03	24	52	2	PF00664
Domain	ABC_TM1F	CFTR ABCC2	2.74e-03	28	52	2	PS50929
Domain	ABC1_TM_dom	CFTR ABCC2	2.74e-03	28	52	2	IPR011527
Domain	-	GLYAT GLYATL2	5.54e-03	40	52	2	3.40.630.30
Domain	Acyl_CoA_acyltransferase	GLYAT GLYATL2	6.97e-03	45	52	2	IPR016181
Pathway	KEGG_ABC_TRANSPORTERS	ABCA4 CFTR ABCC2 ABCA10	6.27e-06	44	39	4	M11911
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	ABCA4 PSME4 CFTR ABCC2 ABCA10	8.93e-06	103	39	5	M758
Pathway	REACTOME_CONJUGATION_OF_BENZOATE_WITH_GLYCINE	GLYAT GLYATL2	1.11e-04	6	39	2	M27037
Pathway	WP_LINOLEIC_ACID_METABOLISM_AFFECTED_BY_SARSCOV2	FADS1 ACOT2	1.11e-04	6	39	2	M42575
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	ABCA4 PSME4 CFTR ABCC2	1.56e-04	99	39	4	MM14986
Pathway	REACTOME_ASPIRIN_ADME	GLYAT GLYATL2 ABCC2	2.40e-04	44	39	3	M45014
Pathway	REACTOME_AMINO_ACID_CONJUGATION	GLYAT GLYATL2	2.65e-04	9	39	2	M26968
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	FADS1 ACOT2	6.65e-04	14	39	2	M39780
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	FADS1 ACOT2	6.65e-04	14	39	2	MM15840
Pathway	WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS	FADS1 ACOT2	7.65e-04	15	39	2	M39789
Pathway	WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS	FADS1 ACOT2	8.73e-04	16	39	2	MM15813
Pubmed	Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity.	BECN1 LEPR	2.37e-06	2	54	2	29898399
Pubmed	Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation.	CFTR BECN1	2.37e-06	2	54	2	25350163
Pubmed	Cysteamine re-establishes the clearance of Pseudomonas aeruginosa by macrophages bearing the cystic fibrosis-relevant F508del-CFTR mutation.	CFTR BECN1	2.37e-06	2	54	2	28079883
Pubmed	The renal TGF-beta system in the db/db mouse model of diabetic nephropathy.	RBPJ LEPR	2.37e-06	2	54	2	9639038
Pubmed	DNA methyltransferase 1 may be a therapy target for attenuating diabetic nephropathy and podocyte injury.	LEPR DNMT1	2.37e-06	2	54	2	28318634
Pubmed	Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage.	PTGER3 LEPR	2.37e-06	2	54	2	34626853
Pubmed	Absence of leptin signaling allows fat accretion in cystic fibrosis mice.	CFTR LEPR	2.37e-06	2	54	2	30118352
Pubmed	A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR.	CFTR BECN1	2.37e-06	2	54	2	27035618
Pubmed	The Importance of Aquaporin 1 in Pancreatitis and Its Relation to the CFTR Cl- Channel.	CFTR AQP1	2.37e-06	2	54	2	30050452
Pubmed	Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.	ABCA4 ABCC2 ABCA10	5.34e-06	22	54	3	8894702
Pubmed	Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma.	GLYAT GLYATL2	7.09e-06	3	54	2	22475485
Pubmed	Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells.	ABCA4 CFTR	7.09e-06	3	54	2	22572847
Pubmed	Escherichia coli alpha-hemolysin triggers shrinkage of erythrocytes via K(Ca)3.1 and TMEM16A channels with subsequent phosphatidylserine exposure.	CFTR AQP1	7.09e-06	3	54	2	20231275
Pubmed	CFTR-associated ligand is a negative regulator of Mrp2 expression.	CFTR ABCC2	7.09e-06	3	54	2	27834195
Pubmed	Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas.	CFTR AQP1	1.42e-05	4	54	2	12801959
Pubmed	C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins.	CFTR ABCC2	2.36e-05	5	54	2	12615054
Pubmed	Growth deficits in cystic fibrosis mice begin in utero prior to IGF-1 reduction.	CFTR AQP1	3.54e-05	6	54	2	28384265
Pubmed	Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production.	ABCA4 AQP1 LEPR	3.62e-05	41	54	3	25810521
Pubmed	Autophagy protects the retina from light-induced degeneration.	ABCA4 BECN1	4.94e-05	7	54	2	23341467
Pubmed	Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.	HCN3 DNMT1	4.94e-05	7	54	2	27956497
Pubmed	Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.	ANKFY1 ZZEF1	6.59e-05	8	54	2	24039173
Pubmed	Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition.	CFTR BECN1	6.59e-05	8	54	2	20711182
Pubmed	Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity.	LEPR DNMT1	1.55e-04	12	54	2	38512414
Pubmed	Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate.	ANKFY1 DNMT1	3.17e-04	17	54	2	21628590
Pubmed	The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.	CFTR AQP1	3.17e-04	17	54	2	16472605
Pubmed	Generalized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth.	LEPR DNMT1	3.56e-04	18	54	2	23085235
Pubmed	Hrd1-mediated ACLY ubiquitination alleviate NAFLD in db/db mice.	ANKFY1 LEPR	3.98e-04	19	54	2	32888949
Pubmed	Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation.	ZNF844 ZIC1	4.42e-04	20	54	2	12447396
Pubmed	AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis.	TGM3 RBPJ	4.88e-04	21	54	2	18824566
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DMXL2 PSME4 PFAS ZZEF1 PBXIP1 DNMT1	5.02e-04	650	54	6	38777146
Pubmed	Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice†.	CFTR AQP1	6.39e-04	24	54	2	37471646
Pubmed	Meis homeobox genes control progenitor competence in the retina.	AQP1 ZIC1	6.94e-04	25	54	2	33723039
Pubmed	Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.	FADS1 LEPR	7.51e-04	26	54	2	19060910
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DMXL2 STAG1 IFT172 ANKRD6 BECN1 PBXIP1 DNMT1 LGI1	7.80e-04	1285	54	8	35914814
Pubmed	HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.	RBPJ DNMT1	1.14e-03	32	54	2	11748221
Pubmed	Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.	DMXL2 LGI1	1.21e-03	33	54	2	26025364
Pubmed	Genome-wide association study of smoking behaviours among Bangladeshi adults.	TENM3 ARHGAP39	1.29e-03	34	54	2	24665060
Cytoband	10q24	ABCC2 LGI1	7.88e-04	35	54	2	10q24
GeneFamily	ATP binding cassette subfamily C	CFTR ABCC2	3.13e-04	13	37	2	807
GeneFamily	ATP binding cassette subfamily A	ABCA4 ABCA10	3.65e-04	14	37	2	805
ToppCell	metastatic_Lymph_Node-Fibroblasts-COL14A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	EEF2K ABCC2 AQP1 ABCA10 LEPR	3.07e-06	186	54	5	6259f0f2d5bc863782d09a901d6be2f387d1f074
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-BMP_responsible_cell\|6m / Sample Type, Dataset, Time_group, and Cell type.	ABCA4 PBXIP1 LEPR ZIC1 LGI1	4.37e-06	200	54	5	5fb90118d3abc28d72bc483e68317255090a04c7
Disease	Choledochal Cyst, Type II	CFTR AQP1	3.04e-05	5	52	2	C1257796
Disease	Choledochal Cyst, Type III	CFTR AQP1	3.04e-05	5	52	2	C1257797
Disease	Choledochal Cyst, Type IV	CFTR AQP1	3.04e-05	5	52	2	C1257798
Disease	Choledochal Cyst, Type V	CFTR AQP1	3.04e-05	5	52	2	C1257799
Disease	Choledochal Cyst, Type I	CFTR AQP1	3.04e-05	5	52	2	C0009439
Disease	Choledochal Cyst	CFTR AQP1	3.04e-05	5	52	2	C0008340
Disease	Autosomal Recessive Polycystic Kidney Disease	CFTR AQP1	1.09e-04	9	52	2	C0085548
Disease	Colorectal Neoplasms	ABCA4 FADS1 CFTR ABCC2 ABCA10	1.27e-04	277	52	5	C0009404
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	CFTR AQP1	1.66e-04	11	52	2	DOID:0110861 (biomarker_via_orthology)
Disease	X-24588 measurement	ACOT2 ABCC2	2.35e-04	13	52	2	EFO_0800898
Disease	hypertrophic cardiomyopathy (is_marker_for)	BECN1 DNMT1	4.07e-04	17	52	2	DOID:11984 (is_marker_for)
Disease	non-alcoholic fatty liver disease (is_implicated_in)	ABCC2 LEPR	4.58e-04	18	52	2	DOID:0080208 (is_implicated_in)
Disease	hypertension (biomarker_via_orthology)	FADS1 CHST12 AQP1 BECN1	6.91e-04	227	52	4	DOID:10763 (biomarker_via_orthology)
Disease	status epilepticus (biomarker_via_orthology)	ABCC2 AQP1 BECN1	7.40e-04	100	52	3	DOID:1824 (biomarker_via_orthology)
Disease	congestive heart failure (biomarker_via_orthology)	DIO3 BECN1 DNMT1	9.00e-04	107	52	3	DOID:6000 (biomarker_via_orthology)
Disease	C-reactive protein measurement	DMXL2 FADS1 IFT172 HID1 ZZEF1 GK5 SSPOP LEPR	1.16e-03	1206	52	8	EFO_0004458
Disease	Colorectal Carcinoma	ABCA4 FADS1 CFTR DHRS2 ABCC2 ABCA10	1.43e-03	702	52	6	C0009402
Disease	C-reactive protein measurement, high density lipoprotein cholesterol measurement	FADS1 STAG1	1.65e-03	34	52	2	EFO_0004458, EFO_0004612
Disease	Drug Allergy	ABCC2 PTGER3	1.75e-03	35	52	2	C0013182

Protein segments in the cluster

Peptide	Gene	Start	Entry
HSWHQATFRLNVAGS	ACTL10	36	Q5JWF8
HWIHNGSLLNFSDAK	CEACAM18	266	A8MTB9
TLFHKALNLHTANWF	CFTR	1076	P13569
SSNGQMFHAHWFCAG	DNMT1	786	P26358
FFLKSSFWSKHQNTH	ABCA10	346	Q8WWZ4
NKGWHALVSFLNVAH	ABCA4	1621	P78363
SFGSAVITHNFSNHW	AQP1	196	P29972
WKQLQTFFHKHLGGH	ACOT2	461	P49753
LLHQGVSTCHFAWAF	DMXL2	1591	Q8TDJ6
ALHEASWHGFSQSAK	ANKRD6	111	Q9Y2G4
ENWAHYNSSTVKAHG	RAD51AP2	721	Q09MP3
NWASKHFNKHTQGLF	ARHGAP39	696	Q9C0H5
FLATNGAHVNHRNKW	ANKFY1	476	Q9P2R3
FASFSQLTWLHLDHN	LRRTM2	81	O43300
NAARAGASFFSWIQH	MAGED4	726	Q96JG8
AAFQNVISSFHKQWH	NMUR2	336	Q9GZQ4
AVWHGQKLDFFKQAH	DIO3	116	P55073
THAHLVNKFWHFGGN	GLYAT	176	Q6IB77
KTNVFNATFHIWHSG	BECN1	266	Q14457
TNQHLGTHTWKQFFL	FBXW12	56	Q6X9E4
SSHNWGNLFFASAFA	PTGER3	221	P43115
HHSFKGRLDNWSFLQ	GXYLT1	156	Q4G148
GNHTKFTFLWTEQAH	LEPR	696	P48357
KQHSLHSAQWFAGAF	TUBGCP2	666	Q9BSJ2
AHFWSAFGFVHASNI	ABCC2	1041	Q92887
NHSWGRQYSHALFKA	HCN3	291	Q9P1Z3
QGGANAHKHVAYLWA	IFT172	1081	Q9UG01
FGHLSVFSTSKWNHL	FADS1	181	O60427
VHKSAFNDWFSGHLN	FADS1	366	O60427
FITWNKKTGNHFHNF	GK5	101	Q6ZS86
KKTGNHFHNFISWQD	GK5	106	Q6ZS86
ANSFHFKEAWKHAIQ	EEF2K	76	O00418
FHGNESLWKNFKEHH	DHRS2	226	Q13268
FLHFHSVTFWVGNAK	HPD	16	P32754
SSFSLQFSSNGLHWH	SSPOP	2151	A2VEC9
TWFLFSAAQNHHLVF	HID1	516	Q8IV36
WQTAFNRQAHHTDKF	TGM3	11	Q08188
HVHNASAHLTFNKFW	CHST12	206	Q9NRB3
GKAFSQSSHLNVHWR	ZNF671	431	Q8TAW3
FHNQLWHVLTGRAFT	TMC8	166	Q8IU68
AFNWSSDFNKHKRIH	ZNF826P	156	Q6ZT77
ASKAWHQKSHFQNSR	PBXIP1	456	Q96AQ6
NSEHSRHWFFKGQLH	PFAS	226	O15067
AVAFHSVKNHYNWGE	ZNF256	201	Q9Y2P7
ASSQAAVSARFGHWH	STXBP2	506	Q15833
KWLTEHFFHASTQGI	TMPRSS12	311	Q86WS5
FHNAHDLTKWDLFGN	STAG1	701	Q8WVM7
VNSWLVTFGFHLHNA	TENM3	2406	Q9P273
LQFQGSHKHEFDSRW	PSME4	901	Q14997
HASSQQWGAFFIHLL	RBPJ	211	Q06330
CGKAFRWFHSFQIHE	ZNF844	286	Q08AG5
HTAGHSALSSNFNEW	ZIC1	431	Q15915
LQFLFHSDSSHNEWG	ZZEF1	1171	O43149
KGFSWSSHLQAHQRV	ZNF233	571	A6NK53
SHAGLVNEHWAFGKN	GLYATL2	171	Q8WU03
KWNGNGFYSHQSLHA	LGI1	361	O95970