Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRho-dependent protein serine/threonine kinase activity

ROCK2 ROCK1

5.19e-062462GO:0072518
GeneOntologyMolecularFunctiongamma-aminobutyric acid:sodium:chloride symporter activity

SLC6A6 SLC6A8

7.74e-056462GO:0005332
GeneOntologyMolecularFunctiongamma-aminobutyric acid transmembrane transporter activity

SLC6A6 SLC6A8

1.85e-049462GO:0015185
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1A GRIA3 TRPC7 RYR1

2.20e-04129464GO:0005262
GeneOntologyMolecularFunctionhistone deacetylase binding

MTA2 MTA1 MTA3 AKAP8L

3.62e-04147464GO:0042826
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1A GRIA3 TRPC7 RYR1

4.01e-04151464GO:0015085
GeneOntologyMolecularFunctionmonocarboxylate:sodium symporter activity

SLC6A6 SLC6A8

5.35e-0415462GO:0140161
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC6A6 CACNA1A SLC6A8 GRIA3 TRPC7 RYR1

6.57e-04465466GO:0046873
GeneOntologyMolecularFunctionsodium:chloride symporter activity

SLC6A6 SLC6A8

6.91e-0417462GO:0015378
GeneOntologyMolecularFunctionRNA helicase activity

DHX29 SNRNP200 MOV10L1

7.71e-0478463GO:0003724
GeneOntologyMolecularFunctionATP-dependent activity, acting on RNA

DHX29 SNRNP200 MOV10L1

8.30e-0480463GO:0008186
GeneOntologyMolecularFunctionsecondary active monocarboxylate transmembrane transporter activity

SLC6A6 SLC6A8

8.66e-0419462GO:0015355
GeneOntologyMolecularFunctionmonoatomic anion:sodium symporter activity

SLC6A6 SLC6A8

8.66e-0419462GO:0015373
GeneOntologyMolecularFunctionmyosin V binding

RAB3A RAB3B

9.61e-0420462GO:0031489
GeneOntologyMolecularFunctiontau-protein kinase activity

ROCK2 ROCK1

1.16e-0322462GO:0050321
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC6A6 SLC6A8

1.27e-0323462GO:0015377
GeneOntologyMolecularFunctionamino acid:sodium symporter activity

SLC6A6 SLC6A8

1.27e-0323462GO:0005283
GeneOntologyMolecularFunctionGTP-dependent protein binding

RAB3A RAB3B

1.39e-0324462GO:0030742
GeneOntologyMolecularFunctionprotein serine kinase activity

ROCK2 PRKCB ROCK1 CSNK1A1L BCR

1.44e-03363465GO:0106310
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC6A6 SLC6A8

1.63e-0326462GO:0015296
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC6A6 SLC6A8 GRIA3

1.82e-03105463GO:0015171
GeneOntologyMolecularFunctionamino acid:monoatomic cation symporter activity

SLC6A6 SLC6A8

2.03e-0329462GO:0005416
GeneOntologyMolecularFunctionligand-gated calcium channel activity

GRIA3 RYR1

2.31e-0331462GO:0099604
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC6A6 SLC6A8

2.94e-0335462GO:0005343
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC6A6 CACNA1A SLC6A8 GRIA3 TRPC7 RYR1

3.01e-03627466GO:0022890
GeneOntologyMolecularFunctionodorant binding

OR5M11 OR8B2 OR8B3

3.12e-03127463GO:0005549
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

ROCK2 PRKCB ROCK1 CSNK1A1L BCR

3.51e-03446465GO:0004674
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC6A6 CACNA1A SLC6A8 GRIA3 TRPC7 RYR1

3.99e-03664466GO:0008324
GeneOntologyMolecularFunctiontau protein binding

ROCK2 ROCK1

5.04e-0346462GO:0048156
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1A RYR1

5.04e-0346462GO:0005245
GeneOntologyMolecularFunctiontranscription coactivator activity

MTA2 PRKCB MTA1 MTA3

5.14e-03303464GO:0003713
GeneOntologyMolecularFunctionhelicase activity

DHX29 SNRNP200 MOV10L1

5.75e-03158463GO:0004386
GeneOntologyMolecularFunctionchannel activity

CACNA1A GRIA3 GJB2 TRPC7 RYR1

6.95e-03525465GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1A GRIA3 GJB2 TRPC7 RYR1

7.01e-03526465GO:0022803
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC6A6 CACNA1A SLC6A8 GRIA3 TRPC7 RYR1

7.54e-03758466GO:0015318
GeneOntologyBiologicalProcessneurotransmitter transport

SLC6A6 CACNA1A SLC6A8 PRKCB RAB3A RAB3B DDC

1.37e-06259457GO:0006836
GeneOntologyBiologicalProcessamine transport

CACNA1A PRKCB RAB3A RAB3B DDC

1.19e-05137455GO:0015837
GeneOntologyBiologicalProcesssynaptic vesicle cycle

CACNA1A PRKCB ROCK1 RAB3A RAB3B DDC

2.23e-05264456GO:0099504
GeneOntologyBiologicalProcessregulation of angiotensin-activated signaling pathway

ROCK2 ROCK1

2.78e-054452GO:0110061
GeneOntologyBiologicalProcessgamma-aminobutyric acid transport

SLC6A6 CACNA1A SLC6A8

3.06e-0528453GO:0015812
GeneOntologyBiologicalProcessregulation of cell fate specification

MTA2 MTA1 MTA3

3.41e-0529453GO:0042659
GeneOntologyBiologicalProcessvesicle-mediated transport in synapse

CACNA1A PRKCB ROCK1 RAB3A RAB3B DDC

6.62e-05321456GO:0099003
GeneOntologyBiologicalProcessnegative regulation of bicellular tight junction assembly

ROCK2 ROCK1

9.71e-057452GO:1903347
GeneOntologyBiologicalProcessregulation of exocytosis

CACNA1A PRKCB BCR RAB3A RAB3B

1.49e-04233455GO:0017157
GeneOntologyBiologicalProcessregulation of amine transport

CACNA1A PRKCB RAB3A RAB3B

1.58e-04125454GO:0051952
GeneOntologyBiologicalProcessregulation of cell fate commitment

MTA2 MTA1 MTA3

2.11e-0453453GO:0010453
GeneOntologyBiologicalProcessregulation of neurotransmitter transport

CACNA1A PRKCB RAB3A RAB3B

2.51e-04141454GO:0051588
GeneOntologyBiologicalProcessdopamine transport

PRKCB RAB3A RAB3B

2.61e-0457453GO:0015872
GeneOntologyBiologicalProcessestablishment of endothelial barrier

ROCK2 ROCK1 PTPRS

2.75e-0458453GO:0061028
GeneOntologyBiologicalProcesspositive regulation of connective tissue replacement

ROCK2 ROCK1

3.58e-0413452GO:1905205
GeneOntologyBiologicalProcessnuclear membrane disassembly

PRKCB AKAP8L

3.58e-0413452GO:0051081
GeneOntologyBiologicalProcessmembrane disassembly

PRKCB AKAP8L

4.17e-0414452GO:0030397
GeneOntologyBiologicalProcessRho protein signal transduction

ROCK2 ROCK1 CSNK1A1L BCR

4.45e-04164454GO:0007266
GeneOntologyBiologicalProcessregulation of regulated secretory pathway

CACNA1A PRKCB BCR RAB3A

4.56e-04165454GO:1903305
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

SLC6A6 CACNA1A PRKCB GRIA3 BCR RAB3A PTPRS

5.38e-04663457GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

SLC6A6 CACNA1A PRKCB GRIA3 BCR RAB3A PTPRS

5.43e-04664457GO:0099177
GeneOntologyCellularComponentCHD-type complex

MTA2 MTA1 MTA3

6.64e-0617463GO:0090545
GeneOntologyCellularComponentNuRD complex

MTA2 MTA1 MTA3

6.64e-0617463GO:0016581
GeneOntologyCellularComponentSWI/SNF superfamily-type complex

MTA2 MTA1 SF3B1 MTA3

5.88e-0596464GO:0070603
GeneOntologyCellularComponentpresynapse

ROCK2 CACNA1A PRKCB GRIA3 OPN1SW RAB3A RAB3B PTPRS DDC

1.14e-04886469GO:0098793
GeneOntologyCellularComponentATPase complex

MTA2 MTA1 SF3B1 MTA3

1.85e-04129464GO:1904949
GeneOntologyCellularComponentpresynaptic active zone

ROCK2 CACNA1A GRIA3 RAB3A

2.60e-04141464GO:0048786
GeneOntologyCellularComponentSchaffer collateral - CA1 synapse

ROCK2 ROCK1 BCR PTPRS

3.72e-04155464GO:0098685
GeneOntologyCellularComponentaxon

PRKCB GRIA3 N4BP3 OPN1SW BCR RAB3A PTPRS DDC

6.52e-04891468GO:0030424
GeneOntologyCellularComponentcell body

SLC6A6 CACNA1A GRIA3 GJB2 SERPINI1 OPN1SW PTPRS DDC

8.57e-04929468GO:0044297
GeneOntologyCellularComponenthistone deacetylase complex

MTA2 MTA1 MTA3

8.68e-0485463GO:0000118
GeneOntologyCellularComponentaxon terminus

PRKCB GRIA3 OPN1SW RAB3A

1.16e-03210464GO:0043679
GeneOntologyCellularComponentterminal bouton

GRIA3 OPN1SW RAB3A

1.23e-0396463GO:0043195
GeneOntologyCellularComponentperikaryon

CACNA1A GRIA3 SERPINI1 PTPRS

1.45e-03223464GO:0043204
GeneOntologyCellularComponentpostsynapse

ROCK2 SLC6A6 CACNA1A SLC6A8 GRIA3 BCR RAB3A PTPRS

1.54e-031018468GO:0098794
GeneOntologyCellularComponentneuron projection terminus

PRKCB GRIA3 OPN1SW RAB3A

1.70e-03233464GO:0044306
GeneOntologyCellularComponentpostsynaptic membrane

SLC6A6 CACNA1A SLC6A8 GRIA3 PTPRS

1.90e-03405465GO:0045211
GeneOntologyCellularComponentdistal axon

PRKCB GRIA3 OPN1SW RAB3A PTPRS

2.59e-03435465GO:0150034
DomainMyb_DNA-binding

MTA2 MTA1 SNAPC4 MTA3

1.59e-0635464PF00249
DomainMYB_LIKE

MTA2 MTA1 SNAPC4 MTA3

2.24e-0638464PS50090
DomainBAH

MTA2 MTA1 MTA3

2.28e-0611463SM00439
DomainBAH

MTA2 MTA1 MTA3

2.28e-0611463PF01426
DomainBAH_dom

MTA2 MTA1 MTA3

2.28e-0611463IPR001025
DomainBAH

MTA2 MTA1 MTA3

2.28e-0611463PS51038
DomainZnF_GATA

MTA2 MTA1 MTA3

3.03e-0612463SM00401
DomainELM2

MTA2 MTA1 MTA3

3.93e-0613463SM01189
DomainELM2

MTA2 MTA1 MTA3

3.93e-0613463PF01448
DomainELM2

MTA2 MTA1 MTA3

3.93e-0613463PS51156
DomainELM2_dom

MTA2 MTA1 MTA3

3.93e-0613463IPR000949
DomainRho_Binding

ROCK2 ROCK1

5.93e-062462PF08912
DomainRho-bd_dom

ROCK2 ROCK1

5.93e-062462IPR015008
DomainROCK1/ROCK2

ROCK2 ROCK1

5.93e-062462IPR020684
DomainZnf_GATA

MTA2 MTA1 MTA3

6.23e-0615463IPR000679
DomainGATA

MTA2 MTA1 MTA3

6.23e-0615463PF00320
DomainSANT

MTA2 MTA1 SNAPC4 MTA3

6.83e-0650464SM00717
DomainGATA_ZN_FINGER_1

MTA2 MTA1 MTA3

7.66e-0616463PS00344
DomainGATA_ZN_FINGER_2

MTA2 MTA1 MTA3

7.66e-0616463PS50114
DomainSANT/Myb

MTA2 MTA1 SNAPC4 MTA3

7.99e-0652464IPR001005
DomainSANT_dom

MTA2 MTA1 MTA3

3.49e-0526463IPR017884
DomainSANT

MTA2 MTA1 MTA3

4.39e-0528463PS51293
DomainPkinase_C

ROCK2 PRKCB ROCK1

1.02e-0437463IPR017892
DomainPkinase_C

ROCK2 PRKCB ROCK1

1.50e-0442463PF00433
DomainHR1

ROCK2 ROCK1

1.65e-048462PF02185
DomainAGC-kinase_C

ROCK2 PRKCB ROCK1

3.54e-0456463IPR000961
DomainAGC_KINASE_CTER

ROCK2 PRKCB ROCK1

3.54e-0456463PS51285
DomainS_TK_X

ROCK2 PRKCB ROCK1

3.54e-0456463SM00133
DomainZF_DAG_PE_1

ROCK2 PRKCB ROCK1

5.24e-0464463PS00479
DomainZF_DAG_PE_2

ROCK2 PRKCB ROCK1

5.24e-0464463PS50081
DomainC1

ROCK2 PRKCB ROCK1

5.49e-0465463SM00109
DomainPE/DAG-bd

ROCK2 PRKCB ROCK1

5.74e-0466463IPR002219
DomainNA_NEUROTRAN_SYMP_2

SLC6A6 SLC6A8

8.85e-0418462PS00754
DomainNA_NEUROTRAN_SYMP_3

SLC6A6 SLC6A8

9.88e-0419462PS50267
DomainSNF

SLC6A6 SLC6A8

9.88e-0419462PF00209
DomainNa/ntran_symport

SLC6A6 SLC6A8

9.88e-0419462IPR000175
DomainNA_NEUROTRAN_SYMP_1

SLC6A6 SLC6A8

9.88e-0419462PS00610
DomainIon_trans_dom

CACNA1A TRPC7 RYR1

2.78e-03114463IPR005821
DomainIon_trans

CACNA1A TRPC7 RYR1

2.78e-03114463PF00520
Domain-

PRKCB BCR SNRNP200

5.77e-031484632.60.40.150
DomainC2_dom

PRKCB BCR SNRNP200

7.65e-03164463IPR000008
DomainC1_1

ROCK2 PRKCB

8.69e-0357462PF00130
DomainHomeodomain-like

MTA2 MTA1 SNAPC4 MTA3

8.90e-03332464IPR009057
Domain-

DSEL RAB3A DHX29 RAB3B SNRNP200 MOV10L1

9.56e-037464663.40.50.300
DomainSer/Thr_kinase_AS

ROCK2 PRKCB ROCK1 CSNK1A1L

1.14e-02357464IPR008271
DomainS_TKc

ROCK2 PRKCB ROCK1 CSNK1A1L

1.16e-02359464SM00220
DomainPROTEIN_KINASE_ST

ROCK2 PRKCB ROCK1 CSNK1A1L

1.19e-02362464PS00108
PathwayWP_AIRWAY_SMOOTH_MUSCLE_CELL_CONTRACTION

ROCK2 ROCK1 RYR1

9.88e-0616383M40060
PathwayKEGG_LONG_TERM_DEPRESSION

CACNA1A PRKCB GRIA3 RYR1

3.62e-0570384M8232
PathwayREACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION

MTA2 MTA1 MTA3

5.05e-0527383MM15537
PathwayREACTOME_POTENTIAL_THERAPEUTICS_FOR_SARS

MTA2 ROCK2 ROCK1 MTA1 MTA3

5.47e-05154385M39007
PathwayKEGG_MEDICUS_PATHOGEN_ESCHERICHIA_MAP_TO_LPA_GNA12_13_RHOA_SIGNALING_PATHWAY

ROCK2 ROCK1

7.04e-055382M49031
PathwayREACTOME_RHO_GTPASES_ACTIVATE_ROCKS

ROCK2 ROCK1

7.04e-055382MM15221
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_BROWN_AND_BEIGE_ADIPOCYTE_DIFFERENTIATION

MTA2 MTA1 MTA3

7.71e-0531383M48258
PathwayWP_EFFECT_OF_PROGERIN_ON_GENES_INVOLVED_IN_PROGERIA

MTA2 MTA1 MTA3

1.32e-0437383M39756
PathwayREACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION

MTA2 MTA1 SF3B1 MTA3

1.77e-04105384M27425
PathwayPID_THROMBIN_PAR1_PATHWAY

ROCK2 PRKCB ROCK1

2.07e-0443383M238
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNA12_13_RHO_SIGNALING_PATHWAY

ROCK2 ROCK1

2.52e-049382M47546
PathwayREACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_INITIATION

MTA2 MTA1 MTA3

2.70e-0447383M1095
PathwayREACTOME_RNA_POLYMERASE_I_TRANSCRIPTION

MTA2 MTA1 MTA3

2.70e-0447383MM15428
PathwayREACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE

ROCK2 ROCK1

3.83e-0411382MM15046
PathwayKEGG_MEDICUS_PATHOGEN_SHIGELLA_IPAA_TO_ITGA_B_RHOGEF_RHOA_SIGNALING_PATHWAY

ROCK2 ROCK1

3.83e-0411382M47721
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1A RYR1

3.83e-0411382M47958
PathwayBIOCARTA_MYOSIN_PATHWAY

PRKCB ROCK1

3.83e-0411382M7014
PathwayREACTOME_HDACS_DEACETYLATE_HISTONES

MTA2 MTA1 MTA3

4.30e-0455383MM14932
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNA12_13_RHO_SIGNALING_PATHWAY

ROCK2 ROCK1

5.42e-0413382M47547
PathwayKEGG_MEDICUS_REFERENCE_LPA_GNA12_13_RHOA_SIGNALING_PATHWAY

ROCK2 ROCK1

5.42e-0413382M47731
PathwayREACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION

MTA2 MTA1 SF3B1 MTA3 AKAP8L

5.64e-04254385M27131
PathwayREACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION

MTA2 MTA1 MTA3

5.84e-0461383M27811
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1A PRKCB GJB2 RYR1

6.36e-04147384MM15854
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1A PRKCB GJB2 RYR1

7.03e-04151384M39329
PathwayKEGG_WNT_SIGNALING_PATHWAY

ROCK2 PRKCB ROCK1 CSNK1A1L

7.03e-04151384M19428
PathwayPID_THROMBIN_PAR4_PATHWAY

ROCK2 ROCK1

7.27e-0415382M138
PathwayREACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING

ROCK2 ROCK1

7.27e-0415382MM15037
PathwayREACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS

PRKCB GRIA3

8.29e-0416382MM15048
PathwayREACTOME_RHOB_GTPASE_CYCLE

ROCK2 ROCK1 BCR

8.37e-0469383MM15596
PathwayREACTOME_RHOB_GTPASE_CYCLE

ROCK2 ROCK1 BCR

8.73e-0470383M41806
PathwayREACTOME_RHOC_GTPASE_CYCLE

ROCK2 ROCK1 BCR

8.73e-0470383MM15597
PathwayREACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS

PRKCB GRIA3

9.38e-0417382M5488
PathwayREACTOME_RHOC_GTPASE_CYCLE

ROCK2 ROCK1 BCR

1.03e-0374383M41807
PathwayBIOCARTA_MTA3_PATHWAY

MTA1 MTA3

1.05e-0318382M225
PathwayREACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION

MTA2 MTA1 MTA3

1.07e-0375383M27343
PathwayBIOCARTA_CCR3_PATHWAY

ROCK2 PRKCB

1.18e-0319382MM1361
PathwayBIOCARTA_PAR1_PATHWAY

PRKCB ROCK1

1.18e-0319382MM1514
PathwayBIOCARTA_PAR1_PATHWAY

PRKCB ROCK1

1.18e-0319382M3494
PathwayREACTOME_RHO_GTPASES_ACTIVATE_ROCKS

ROCK2 ROCK1

1.18e-0319382M27493
PathwayBIOCARTA_CCR3_PATHWAY

ROCK2 PRKCB

1.18e-0319382M9152
PathwayWP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY

MTA2 ROCK2 ROCK1 MTA1 PTPRS

1.21e-03301385MM15983
PathwayREACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE

ROCK2 ROCK1

1.30e-0320382M18415
PathwayREACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES

GRIA3 PTPRS

1.30e-0320382MM15485
PathwayBIOCARTA_MTA3_PATHWAY

MTA1 MTA3

1.30e-0320382MM1383
PathwayREACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES

GRIA3 PTPRS

1.44e-0321382M27736
PathwayKEGG_MEDICUS_REFERENCE_MICROTUBULE_RHOA_SIGNALING_PATHWAY

ROCK2 ROCK1

1.44e-0321382M47767
PathwayWP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA

CACNA1A GRIA3

1.58e-0322382M39795
PathwayREACTOME_RHOBTB1_GTPASE_CYCLE

ROCK2 ROCK1

1.73e-0323382M41817
PathwayREACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING

ROCK2 ROCK1

1.88e-0324382M2243
PathwayWP_EFFECTS_OF_MFN2_MUTATION

RAB3A RAB3B

1.88e-0324382M48308
PathwayREACTOME_NEURONAL_SYSTEM

CACNA1A PRKCB GRIA3 RAB3A PTPRS

1.94e-03335385MM14503
PathwayREACTOME_RHOBTB1_GTPASE_CYCLE

ROCK2 ROCK1

2.04e-0325382MM15608
PathwayREACTOME_HDACS_DEACETYLATE_HISTONES

MTA2 MTA1 MTA3

2.05e-0394383M27230
PathwayREACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS_BY_PIWI_INTERACTING_RNAS_PIRNAS

MTA2 MTA1 MTA3

2.24e-0397383M48262
PathwayREACTOME_PTEN_REGULATION

MTA2 MTA1 MTA3

2.30e-0398383MM15348
PathwayWP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY

ROCK2 PRKCB ROCK1

2.37e-0399383MM15905
PathwayWP_INTRACELLULAR_TRAFFICKING_PROTEINS_INVOLVED_IN_CMT_NEUROPATHY

RAB3A RAB3B

2.38e-0327382M39899
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

CACNA1A PRKCB GRIA3 RAB3A

2.42e-03211384MM14502
PathwayREACTOME_SIGNALING_BY_VEGF

ROCK2 PRKCB ROCK1

2.65e-03103383MM14752
PathwayWP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY

ROCK2 PRKCB ROCK1

2.73e-03104383M39625
PathwayREACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE

ROCK2 ROCK1

2.74e-0329382M27309
PathwayREACTOME_TRAFFICKING_OF_AMPA_RECEPTORS

PRKCB GRIA3

2.74e-0329382MM15028
PathwayREACTOME_SIGNALING_BY_VEGF

ROCK2 PRKCB ROCK1

2.88e-03106383M27077
PathwayREACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS_BY_KRAB_ZFP_PROTEINS

MTA2 MTA1 MTA3

2.96e-03107383M48260
PathwayREACTOME_TRAFFICKING_OF_AMPA_RECEPTORS

PRKCB GRIA3

3.13e-0331382M7223
PathwayREACTOME_ADIPOGENESIS

MTA2 MTA1 MTA3

3.20e-03110383M48259
PathwayREACTOME_RNA_POLYMERASE_I_TRANSCRIPTION

MTA2 MTA1 MTA3

3.20e-03110383M27696
PathwayBIOCARTA_INTEGRIN_PATHWAY

ROCK1 BCR

3.54e-0333382MM1426
PathwayKEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION

ROCK2 PRKCB ROCK1

3.62e-03115383M9387
PathwayKEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION

ROCK2 PRKCB ROCK1

3.71e-03116383M2164
PathwayBIOCARTA_INTEGRIN_PATHWAY

ROCK1 BCR

3.76e-0334382M3342
PathwaySIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES

ROCK2 ROCK1

3.98e-0335382M16801
PathwayREACTOME_RHOBTB_GTPASE_CYCLE

ROCK2 ROCK1

3.98e-0335382M41738
PathwayREACTOME_RHOH_GTPASE_CYCLE

ROCK2 ROCK1

4.21e-0336382MM15603
PathwayREACTOME_RHOH_GTPASE_CYCLE

ROCK2 ROCK1

4.44e-0337382M41813
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

ROCK2 ROCK1

4.44e-0337382MM15022
PathwayREACTOME_RHOBTB_GTPASE_CYCLE

ROCK2 ROCK1

4.44e-0337382MM15683
PathwayREACTOME_NEURONAL_SYSTEM

CACNA1A PRKCB GRIA3 RAB3A PTPRS

4.67e-03411385M735
PathwayWP_G13_SIGNALING

ROCK2 ROCK1

4.68e-0338382M39606
PathwayWP_G13_SIGNALING_PATHWAY

ROCK2 ROCK1

4.92e-0339382MM15898
PathwayWP_COMMON_PATHWAYS_UNDERLYING_DRUG_ADDICTION

PRKCB GRIA3

5.43e-0341382M39655
Pubmed

Identification and characterization of metastasis-associated gene/protein 1 (MTA1).

MTA2 MTA1 MTA3

2.17e-09346325315816
Pubmed

Structure, expression and functions of MTA genes.

MTA2 MTA1 MTA3

2.17e-09346326869315
Pubmed

The Nucleosome Remodelling and Deacetylation complex suppresses transcriptional noise during lineage commitment.

MTA2 MTA1 MTA3

2.16e-08546331036553
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

ROCK2 CACNA1A PRKCB GRIA3 ROCK1 CSNK1A1L SF3B1 BCR RAB3A RAB3B PTPRS

3.81e-08963461128671696
Pubmed

The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex.

MTA2 MTA1 MTA3

1.21e-07846318067919
Pubmed

Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis.

MTA2 MTA1 MTA3

1.81e-07946326028330
Pubmed

RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene.

MTA2 MTA1 MTA3

1.81e-07946322926524
Pubmed

PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.

MTA2 MTA1 MTA3

2.58e-071046334180153
Pubmed

NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.

MTA2 MTA1 MTA3

4.72e-071246322560079
Pubmed

Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development.

MTA2 MTA1 MTA3

4.72e-071246320720167
Pubmed

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer.

MTA2 MTA1 MTA3

6.14e-071346319703393
Pubmed

The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.

MTA2 MTA1 MTA3

6.14e-071346312920132
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

ROCK2 MTA1 SF3B1 SNAPC4 FBXO4 DHX29 SNRNP200 AKAP8L USP47

6.74e-0777446915302935
Pubmed

MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

MTA2 MTA1 MTA3

7.80e-071446316428440
Pubmed

NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.

MTA2 MTA1 MTA3

7.80e-071446325150861
Pubmed

The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1.

MTA2 MTA1 MTA3

9.74e-071546325247294
Pubmed

NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development.

MTA2 MTA1 MTA3

9.74e-071546319927129
Pubmed

ROCK 1 and 2 affect the spatial architecture of 3D spheroids derived from human corneal stromal fibroblasts in different manners.

ROCK2 ROCK1

1.71e-06246235523828
Pubmed

Inhibition of Rho kinase protects against colitis in mice by attenuating intestinal epithelial barrier dysfunction via MLC and the NF-κB pathway.

ROCK2 ROCK1

1.71e-06246229115372
Pubmed

Investigation of the Rho-kinase Gene Polymorphism in Primary Open-angle Glaucoma.

ROCK2 ROCK1

1.71e-06246224617500
Pubmed

[Ouabain induces Rho-dependent rock activation and membrane blebbing incultured endothelial cells].

ROCK2 ROCK1

1.71e-06246225916120
Pubmed

Sulfide induces apoptosis and Rho kinase-dependent cell blebbing in Jurkat cells.

ROCK2 ROCK1

1.71e-06246223479079
Pubmed

Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension.

ROCK2 ROCK1

1.71e-06246219590140
Pubmed

Rho-GTPase effector ROCK phosphorylates cofilin in actin-meditated cytokinesis during mouse oocyte meiosis.

ROCK2 ROCK1

1.71e-06246224429217
Pubmed

Rocks: multifunctional kinases in cell behaviour.

ROCK2 ROCK1

1.71e-06246212778124
Pubmed

Rho kinases regulate corneal epithelial wound healing.

ROCK2 ROCK1

1.71e-06246218495812
Pubmed

ROCK inhibitor Y-27632 inhibits the growth, migration, and invasion of Tca8113 and CAL-27 cells in tongue squamous cell carcinoma.

ROCK2 ROCK1

1.71e-06246226468018
Pubmed

ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens.

ROCK2 ROCK1

1.71e-06246228035042
Pubmed

ROCK1 and ROCK2 regulate epithelial polarisation and geometric cell shape.

ROCK2 ROCK1

1.71e-06246222462535
Pubmed

The metastasis-associated genes MTA1 and MTA3 are abundantly expressed in human placenta and chorionic carcinoma cells.

MTA1 MTA3

1.71e-06246219363681
Pubmed

Distinct Roles For ROCK1 and ROCK2 in the Regulation of Oxldl-Mediated Endothelial Dysfunction.

ROCK2 ROCK1

1.71e-06246230165352
Pubmed

The Role of ROCK in Platelet-Monocyte Collaborative Induction of Thromboinflammation during Acute Coronary Syndrome.

ROCK2 ROCK1

1.71e-06246232877952
Pubmed

Distinct and complementary functions of rho kinase isoforms ROCK1 and ROCK2 in prefrontal cortex structural plasticity.

ROCK2 ROCK1

1.71e-06246230196430
Pubmed

Toll-like receptor signaling in macrophages is regulated by extracellular substrate stiffness and Rho-associated coiled-coil kinase (ROCK1/2).

ROCK2 ROCK1

1.71e-06246229800294
Pubmed

Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts.

ROCK2 ROCK1

1.71e-06246218668558
Pubmed

Role of Rho-kinase in regulation of insulin action and glucose homeostasis.

ROCK2 ROCK1

1.71e-06246216098829
Pubmed

Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth.

ROCK2 ROCK1

1.71e-06246228709411
Pubmed

ROCK1 and ROCK2 Are Down-regulated in Aggressive and Advanced Skin Melanomas - A Clinicopathological Perspective.

ROCK2 ROCK1

1.71e-06246232234882
Pubmed

Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice.

ROCK2 ROCK1

1.71e-06246215096457
Pubmed

Small molecule inhibition of cytoskeletal dynamics in melanoma tumors results in altered transcriptional expression patterns of key genes involved in tumor initiation and progression.

ROCK2 ROCK1

1.71e-06246221471517
Pubmed

Rho kinase inhibitors block melanoma cell migration and inhibit metastasis.

ROCK2 ROCK1

1.71e-06246225840982
Pubmed

ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression.

ROCK2 ROCK1

1.71e-06246222934846
Pubmed

ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo.

ROCK2 ROCK1

1.71e-06246216098146
Pubmed

Functional role of Rho-kinase in ameloblast differentiation.

ROCK2 ROCK1

1.71e-06246221792909
Pubmed

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.

ROCK2 ROCK1

1.71e-06246220803696
Pubmed

Role of Rho Kinase and Fasudil on Synaptic Plasticity in Multiple Sclerosis.

ROCK2 ROCK1

1.71e-06246226481340
Pubmed

Inhibition of ROCK activity allows InlF-mediated invasion and increased virulence of Listeria monocytogenes.

ROCK2 ROCK1

1.71e-06246218331468
Pubmed

The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis.

ROCK2 ROCK1

1.71e-06246229211497
Pubmed

The connection between the cardiac glycoside-induced senescent cell morphology and Rho/Rho kinase pathway.

ROCK2 ROCK1

1.71e-06246230369081
Pubmed

Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice.

ROCK2 ROCK1

1.71e-06246229987023
Pubmed

ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice.

ROCK2 ROCK1

1.71e-0624628772201
Pubmed

ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells.

ROCK2 ROCK1

1.71e-06246219131646
Pubmed

Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors.

ROCK2 ROCK1

1.71e-06246231302146
Pubmed

Role of rho-kinase gene polymorphisms and protein expressions in colorectal cancer development.

ROCK2 ROCK1

1.71e-06246223328676
Pubmed

The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer.

ROCK2 ROCK1

1.71e-06246218695890
Pubmed

Rho kinases regulate the renewal and neural differentiation of embryonic stem cells in a cell plating density-dependent manner.

ROCK2 ROCK1

1.71e-06246220169147
Pubmed

Overexpression of MTA1 inhibits the metastatic ability of ZR-75-30 cells in vitro by promoting MTA2 degradation.

MTA2 MTA1

1.71e-06246230642362
Pubmed

Assignment of the metastasis-associated gene (Mta1) to mouse chromosome band 12F and the metastasis-associated gene 2 (Mta2) to mouse chromosome band 19B by fluorescence in situ hybridization.

MTA2 MTA1

1.71e-06246211856890
Pubmed

Opposing signaling of ROCK1 and ROCK2 determines the switching of substrate specificity and the mode of migration of glioblastoma cells.

ROCK2 ROCK1

1.71e-06246224170433
Pubmed

Rho-associated kinases play an essential role in cardiac morphogenesis and cardiomyocyte proliferation.

ROCK2 ROCK1

1.71e-06246212508221
Pubmed

ROCK2 Regulates Monocyte Migration and Cell to Cell Adhesion in Vascular Endothelial Cells.

ROCK2 ROCK1

1.71e-06246230884801
Pubmed

Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts.

ROCK2 ROCK1

1.71e-06246218695640
Pubmed

Rho-associated kinases play a role in endocardial cell differentiation and migration.

ROCK2 ROCK1

1.71e-06246215464581
Pubmed

Investigation of the esophageal Rho-kinase expression in patients with Barrett's esophagus.

ROCK2 ROCK1

1.71e-06246223789633
Pubmed

Role of Rho-Associated Coiled-Coil Forming Kinase Isoforms in Regulation of Stiffness-Induced Myofibroblast Differentiation in Lung Fibrosis.

ROCK2 ROCK1

1.71e-06246228225294
Pubmed

Remnant lipoproteins from patients with sudden cardiac death enhance coronary vasospastic activity through upregulation of Rho-kinase.

ROCK2 ROCK1

1.71e-06246215044207
Pubmed

ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.

ROCK2 ROCK1

1.71e-06246218414683
Pubmed

ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in mice.

ROCK2 ROCK1

1.71e-06246231914704
Pubmed

Differential regulation of adhesion complex turnover by ROCK1 and ROCK2.

ROCK2 ROCK1

1.71e-06246222348083
Pubmed

Function and regulation of MTA1 and MTA3 in malignancies of the female reproductive system.

MTA1 MTA3

1.71e-06246225319202
Pubmed

ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness.

ROCK2 ROCK1

1.71e-06246230771534
Pubmed

Rho-associated kinase is a therapeutic target in neuroblastoma.

ROCK2 ROCK1

1.71e-06246228739902
Pubmed

Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2.

ROCK2 ROCK1

1.71e-06246226826790
Pubmed

ROCK inhibition prevents early mouse embryo development.

ROCK2 ROCK1

1.71e-06246224562870
Pubmed

Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both In Vitro and In Vivo.

ROCK2 ROCK1

1.71e-06246225934709
Pubmed

Common variants of ROCKs and the risk of hypertension, and stroke: Two case-control studies and a follow-up study in Chinese Han population.

ROCK2 ROCK1

1.71e-06246229246448
Pubmed

ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice.

ROCK2 ROCK1

1.71e-06246226276827
Pubmed

Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction.

ROCK2 ROCK1

1.71e-06246228679962
Pubmed

Fasudil, an inhibitor of Rho-associated coiled-coil kinase, improves cognitive impairments induced by smoke exposure.

ROCK2 ROCK1

1.71e-06246227791202
Pubmed

ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease.

ROCK2 ROCK1

1.71e-06246238199985
Pubmed

Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation.

ROCK2 ROCK1

1.71e-06246217167780
Pubmed

ROCK in CNS: Different Roles of Isoforms and Therapeutic Target for Neurodegenerative Disorders.

ROCK2 ROCK1

1.71e-06246227033194
Pubmed

Association of Rho-kinase Gene Polymorphisms with Respiratory Distress Syndrome in Preterm Neonates.

ROCK2 ROCK1

1.71e-06246227269648
Pubmed

Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma.

ROCK2 ROCK1

1.71e-06246225755711
Pubmed

Hyperoxia increases the elastic modulus of alveolar epithelial cells through Rho kinase.

ROCK2 ROCK1

1.71e-06246224289040
Pubmed

Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma.

ROCK2 ROCK1

1.71e-06246233278350
Pubmed

Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment.

ROCK2 ROCK1

1.71e-06246223392171
Pubmed

Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout.

ROCK2 ROCK1

1.71e-06246223250919
Pubmed

Up-regulation of Rho-associated kinase 1/2 by glucocorticoids promotes migration, invasion and metastasis of melanoma.

ROCK2 ROCK1

1.71e-06246228923399
Pubmed

Rho kinase in the regulation of cell death and survival.

ROCK2 ROCK1

1.71e-06246217347801
Pubmed

Ser1333 phosphorylation indicates ROCKI activation.

ROCK2 ROCK1

1.71e-06246224168723
Pubmed

Distinct distribution and localization of Rho-kinase in mouse epithelial, muscle and neural tissues.

ROCK2 ROCK1

1.71e-06246222986902
Pubmed

Dissecting the roles of ROCK isoforms in stress-induced cell detachment.

ROCK2 ROCK1

1.71e-06246223598717
Pubmed

Activation of Rho kinase isoforms in lung endothelial cells during inflammation.

ROCK2 ROCK1

1.71e-06246219201893
Pubmed

ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs.

ROCK2 ROCK1

1.71e-06246229044117
Pubmed

Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation.

ROCK2 ROCK1

1.71e-06246219997641
Pubmed

Inhibition of MTA2 and MTA3 induces mesendoderm specification of human embryonic stem cells.

MTA2 MTA3

1.71e-06246233744762
Pubmed

Role of Rho kinase isoforms in murine allergic airway responses.

ROCK2 ROCK1

1.71e-06246221565918
Pubmed

Inhibitors of Rho kinase (ROCK) signaling revert the malignant phenotype of breast cancer cells in 3D context.

ROCK2 ROCK1

1.71e-06246227203208
Pubmed

Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization.

ROCK2 ROCK1

1.71e-06246222355071
InteractionZBTB2 interactions

MTA2 ROCK2 ROCK1 MTA1 SF3B1 MTA3 SNRNP200 AKAP8L

5.08e-06450448int:ZBTB2
InteractionFOXK2 interactions

MTA2 MTA1 SF3B1 MTA3 SNRNP200 USP47

8.97e-06225446int:FOXK2
InteractionMLNR interactions

TBC1D15 RAB3A RAB3B VPS8

1.45e-0568444int:MLNR
InteractionH3C7 interactions

MTA2 MTA1 MTA3 RAB3B

1.93e-0573444int:H3C7
InteractionRNU11 interactions

SF3B1 SNRNP200 TOE1

3.06e-0528443int:RNU11
InteractionZFPM2 interactions

MTA2 MTA1 MTA3

3.06e-0528443int:ZFPM2
InteractionZNF827 interactions

MTA2 MTA1 MTA3

3.41e-0529443int:ZNF827
InteractionTCF19 interactions

MTA2 MTA1 MTA3

4.61e-0532443int:TCF19
InteractionKDM5B interactions

MTA2 CACNA1A SNAPC4 MTA3

6.65e-05100444int:KDM5B
InteractionSTAG1 interactions

MTA2 MTA1 SF3B1 SNRNP200

7.75e-05104444int:STAG1
InteractionMBD3L2 interactions

MTA2 MTA1 MTA3

9.77e-0541443int:MBD3L2
InteractionHMG20B interactions

MTA2 MTA1 SF3B1 MTA3

1.44e-04122444int:HMG20B
InteractionNACC2 interactions

MTA2 MTA1 MTA3

1.57e-0448443int:NACC2
InteractionCDK2AP2 interactions

MTA2 MTA1 MTA3

1.67e-0449443int:CDK2AP2
InteractionFAM219A interactions

MTA2 MTA1 MTA3

1.77e-0450443int:FAM219A
InteractionLIN52 interactions

MTA2 MTA1 MTA3

1.88e-0451443int:LIN52
InteractionGATA4 interactions

MTA2 MTA1 SF3B1 MTA3 SNRNP200 AKAP8L

2.54e-04411446int:GATA4
GeneFamilyPHD finger proteins|NuRD complex

MTA2 MTA1 MTA3

1.10e-06123231305
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

MTA2 MTA1 SNAPC4 MTA3

2.23e-0653324532
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

MTA2 MTA1 MTA3

2.26e-061532382
GeneFamilyOlfactory receptors, family 8

OR8B2 OR8B3

3.39e-0349322155
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ROCK2 ROCK1 BCR

5.67e-03206323682
GeneFamilyRAB, member RAS oncogene GTPases

RAB3A RAB3B

5.89e-0365322388
CoexpressionGSE10325_BCELL_VS_LUPUS_BCELL_UP

SLC6A8 GRIA3 RAB3A PGC BTBD7

1.62e-05194435M3094
ToppCell5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EECs|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A GRIA3 DSEL RAB3B

2.90e-05171464dd37e1693a5cfc42e40992d504f92048a8038b52
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A TRPC7 RAB3B DDC

2.97e-051724642651dece87c3e3d2d6370f5274ebae357474b825
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A TRPC7 RAB3B DDC

3.47e-05179464d70791d2a0db35a6b013fa7ed2f9f39364581eff
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRIA3 GJB2 SERPINI1 VPS8

3.47e-05179464e880c507f11ce75d104593a4ca29f0295f8125e8
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A TRPC7 RAB3B DDC

3.47e-05179464ec7c38464863ac3744a8d4880f49421914892339
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A TRPC7 RAB3B DDC

3.55e-051804646b1606238417490e0d9930870a7827419d1c3737
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A TRPC7 RAB3B DDC

3.86e-051844641e6f86f9e379cd9f453f6b7185f681b44eb63e09
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A TRPC7 RAB3B DDC

3.95e-05185464eb78614c4acf8d2ce7874d7e51e16997b76127ef
ToppCellfacs-Pancreas-Endocrine|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRKCB RAB3A RAB3B DDC

4.65e-0519346415c86e20b97b6983410b36d308cddff56d141c98
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GRIA3 DSEL PTPRS ACSS3

4.75e-051944648b81f039f5b25d35a4d5a41b27d4d9360ba22f15
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A6 CACNA1A PRKCB DDC

4.84e-051954643e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A6 CACNA1A PRKCB DDC

4.84e-051954647796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell(08)_PNEC|World / shred by cell type and Timepoint

CACNA1A RAB3A RAB3B DDC

4.94e-051964642ee37155c03cd5009427a4bffe6c80ed2ac6939e
ToppCellControl-PLT_4|Control / Disease Group and Platelet Clusters

TBC1D15 DHX29 VPS13B TOE1

5.14e-05198464387fd3037fd52e4d4c42de0588767e58af228b59
Drug6-methylenetestosterone acetate

MTA2 MTA1 MTA3

1.54e-076463CID000159323
DrugAC1L1JG6

ROCK2 CACNA1A ROCK1

2.77e-0614463CID000005026
DrugBrinzolamide [138890-62-7]; Up 200; 10.4uM; MCF7; HT_HG-U133A

SLC6A6 CACNA1A PRKCB MTA1 RAB3B PTPRS

2.89e-061994663230_UP
DrugRockout

ROCK2 ROCK1

3.99e-062462CID000644354
Drug3,3-dimethylacryloyl chloride

ROCK2 ROCK1

3.99e-062462CID000102394
DrugNSC-114340

ROCK2 ROCK1 RYR1

4.24e-0616463CID000004598
Drug2-aminoethyl diphenylborinate

ROCK2 PRKCB ROCK1 TRPC7 RYR1

5.69e-06127465CID000001598
Drugaescine

ROCK2 PRKCB ROCK1 RYR1

6.54e-0660464CID004555259
DrugAC1L1JVU

ROCK2 PRKCB ROCK1 RYR1

1.36e-0572464CID000005229
Drugnifedipine

ROCK2 CACNA1A PRKCB ROCK1 PGC CYP7A1 RYR1

1.84e-05415467CID000004485
DrugGDP-b-S

ROCK2 CACNA1A PRKCB ROCK1 RAB3A

1.86e-05162465CID000643998
DrugFura-2AM

ROCK2 PRKCB ROCK1 RYR1

1.96e-0579464CID000105091
Drugvanilpyruvic acid

CACNA1A DDC

2.39e-054462CID000014124
Drugdiguanosine pentaphosphate

ROCK2 ROCK1

2.39e-054462CID004577574
Drug8-bromoguanosine 3',5'-cyclic monophosphate

ROCK2 CACNA1A PRKCB ROCK1 PGC RYR1

3.47e-05308466CID000001915
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

SLC6A8 SERPINI1 SNAPC4 RAB3A RAB3B

3.60e-051864657499_UP
Drugtetrahydrooxazine

ROCK2 ROCK1

3.98e-055462CID000449101
DrugA61603

ROCK2 CACNA1A ROCK1

4.04e-0533463CID004038180
DrugCP-319743 [172078-87-4]; Up 200; 10uM; MCF7; HT_HG-U133A

ROCK2 SLC6A8 PRKCB GRIA3 BTBD7

4.09e-051914657486_UP
DrugAC1NSKHR

ROCK2 PRKCB ROCK1

4.42e-0534463CID005311362
DrugAminopurine, 6-benzyl [1214-39-7]; Down 200; 17.8uM; MCF7; HT_HG-U133A

MTA2 SLC6A6 MTA1 N4BP3 BTBD7

4.51e-051954652313_DN
DrugMexiletine hydrochloride [5370-01-4]; Down 200; 18.6uM; MCF7; HT_HG-U133A

MTA2 SLC6A6 SLC6A8 SNAPC4 RAB3B

4.74e-051974653862_DN
DrugIsoxicam [34552-84-6]; Up 200; 12uM; MCF7; HT_HG-U133A

MTA2 PRKCB N4BP3 BTBD7 AKAP8L

4.74e-051974651698_UP
DrugCanrenoic acid potassium salt [2181-04-6]; Down 200; 10uM; MCF7; HT_HG-U133A

SLC6A6 CACNA1A SLC6A8 N4BP3 BTBD7

4.74e-051974652228_DN
DrugN-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; MCF7; HT_HG-U133A

MTA2 SLC6A6 CACNA1A SNAPC4 VPS13B

4.74e-051974653930_DN
DrugVincamine [1617-90-9]; Down 200; 11.2uM; MCF7; HT_HG-U133A

MTA2 MTA1 RAB3A PTPRS BTBD7

4.74e-051974652327_DN
DrugCiprofloxacin hydrochloride [93107-08-5]; Up 200; 10.8uM; MCF7; HT_HG-U133A

CACNA1A RAB3B BTBD7 VPS13B RYR1

4.85e-051984651522_UP
DrugBromocryptine mesylate [22260-51-1]; Up 200; 5.4uM; MCF7; HT_HG-U133A

MTA2 MTA1 RAB3A RAB3B PTPRS

4.85e-051984651507_UP
DrugRisperidone [106266-06-2]; Up 200; 9.8uM; HL60; HT_HG-U133A

MTA1 SNRNP200 BTBD7 VPS13B RYR1

4.85e-051984652947_UP
Drugbrazilein

ROCK2 ROCK1

5.96e-056462CID006453902
Druglevormeloxifene

ROCK2 ROCK1

5.96e-056462ctd:C108255
DrugAC1L1CTF

ROCK2 ROCK1

5.96e-056462CID000002056
Drug12-deoxyphorbol 13-isobutyrate

ROCK2 PRKCB ROCK1

6.70e-0539463CID000107855
Drugdopamine

CACNA1A PRKCB GRIA3 OPN1SW BCR RAB3A DDC RYR1

8.25e-05715468CID000000681
Drug6-BME

ROCK2 ROCK1

8.33e-057462CID005748218
DrugAC1L2VEC

ROCK2 ROCK1

8.33e-057462CID000129320
DrugS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (3S)-3-hydroxy-3-methyl-5-oxohexanethioate

CYP7A1 RYR1

1.11e-048462CID016061173
DrugGGTI-297

ROCK2 ROCK1

1.11e-048462CID009956145
Drugheptenoic acid

ROCK2 ROCK1

1.11e-048462CID000029373
DrugN-palmitoyl-serine

ROCK2 ROCK1

1.11e-048462CID000085997
Drugoxethazaine

ROCK2 ROCK1

1.11e-048462CID000004621
DrugSC-46275

ROCK2 ROCK1

1.11e-048462CID005311427
DrugY-26763

ROCK2 ROCK1

1.11e-048462CID000121878
Drugpimozide

CACNA1A TRPC7 DDC RYR1

1.26e-04127464CID000016362
DrugD-myo-inositol-1,4,5-triphosphate

CACNA1A PRKCB TRPC7 BCR RAB3A RAB3B RYR1

1.33e-04568467CID000000806
DrugP6Chol

ROCK2 ROCK1

1.42e-049462CID000126085
DrugGTP[S]

ROCK2 CACNA1A PRKCB ROCK1 OPN1SW RAB3A RYR1

1.70e-04591467CID000001764
Drugnicardipine

ROCK2 CACNA1A ROCK1 RYR1

2.09e-04145464CID000004473
DrugMCI-154

ROCK2 ROCK1

2.17e-0411462CID000123941
Drugleys

CACNA1A DDC

2.17e-0411462CID000484683
Drugcytosine

MTA2 MTA1 SERPINI1 PPAT BCR DDC

2.48e-04441466CID000000597
Drugoxanol

ROCK2 ROCK1

2.60e-0412462CID000136505
DrugDMEP

ROCK2 ROCK1

2.60e-0412462CID000008344
DrugFeTMPyP

PRKCB DDC

2.60e-0412462CID009853416
DrugU46619

ROCK2 CACNA1A PRKCB ROCK1 RYR1

2.67e-04285465CID000005618
Diseasenicotine dependence (implicated_via_orthology)

TRPC7 DDC

1.49e-0412452DOID:0050742 (implicated_via_orthology)
Diseasealcohol use disorder (implicated_via_orthology)

PRKCB RAB3A RAB3B RYR1

2.23e-04195454DOID:1574 (implicated_via_orthology)
Diseaseextrahepatic cholestasis (biomarker_via_orthology)

GJB2 CYP7A1

3.05e-0417452DOID:13619 (biomarker_via_orthology)
DiseaseBipolar Disorder

CACNA1A GRIA3 TRPC7 BCR DDC

7.75e-04477455C0005586
Diseaseretinitis pigmentosa (implicated_via_orthology)

SLC6A6 SNRNP200

7.79e-0427452DOID:10584 (implicated_via_orthology)
Diseaseemphysema imaging measurement

OR8B2 RAB3A OR8B3

1.45e-03146453EFO_0007626

Protein segments in the cluster

PeptideGeneStartEntry
GYRMEMSIFYVVYFV

CACNA1A

1481

O00555
YRAFVDNYGVAMEMA

BCR

591

P11274
YYFSGECQEVYMAMR

CDCP2

251

Q5VXM1
VTDGAFFDYMAVYRM

FBXO4

131

Q9UKT5
FEAAFMYVFYVMYDG

GJB2

146

P29033
MYVFYVMYDGFSMQR

GJB2

151

P29033
FRMYTRERFEGFMDY

DHX29

991

Q7Z478
YMANYMEGIEGRQVY

DDC

16

P20711
PEMEMAYEGQYDAYR

AKAP8L

151

Q9ULX6
MAANMYRVGDYVYFE

MTA2

1

O94776
YYRGAMGFILMYDIT

RAB3A

91

P20336
YYRGAMGFILMYDIT

RAB3B

91

P20337
FYMLAAMAYDRYVAI

OR5M11

111

Q96RB7
RYCSDYGMIDDMIYF

MOV10L1

46

Q9BXT6
MFGWFAMVIAYVVYY

LRRC3

211

Q9BY71
RGVYAIFGFYDQMSM

GRIA3

96

P42263
REMAFRTEMGLYYSY

DPY19L1

56

Q2PZI1
LYFVMEYVNGGDLMY

PRKCB

416

P05771
RDDMESLGYVFMYFN

CSNK1A1L

201

Q8N752
ECYMLTSMAYDRYVA

OR8B3

111

Q8NGG8
RYQYFVVDPMAEYNM

PTPRS

1801

Q13332
DMRGLFDYMCYYDVV

BTBD7

236

Q9P203
MYSFCYRVMFEAGYL

CYP7A1

171

P22680
LDEDYLYMAYADIMA

RYR1

3716

P21817
ENMVYYFLEESTGYM

RYR1

4626

P21817
AFEFVLEYMDRMVGY

DSEL

141

Q8IZU8
ECYMLTSMAYDRYVA

OR8B2

111

Q96RD0
MMYQQGEFYYGEFSD

SERPINI1

216

Q99574
CYVPYAAFAMYMVNN

OPN1SW

261

P03999
MAANMYRVGDYVYFE

MTA3

1

Q9BTC8
MVTEGGMYVFQLFDY

SLC6A6

446

P31641
NRLYDAMIYVYNRGM

VPS8

676

Q8N3P4
MVTDGGMYVFQLFDY

SLC6A8

461

P48029
MAANMYRVGDYVYFE

MTA1

1

Q13330
DTMDAGYMDEEGYLY

ACSS3

536

Q9H6R3
GYMDEEGYLYVMSRV

ACSS3

541

Q9H6R3
VTYEPMAYMDAAYFG

PGC

61

P20142
LMDAEYANYYTREVM

SF3B1

756

O75533
YFARPDSMFEDQMVY

PPAT

286

Q06203
RGEMQYMYFKAEPYA

USP47

1026

Q96K76
FYAFQDDRYLYMVME

ROCK2

156

O75116
MTYCMYDFDLGYVQG

TBC1D15

441

Q8TC07
YAFQDDRYLYMVMEY

ROCK1

141

Q13464
LYFMSDAYMGCDQEY

SNRNP200

2106

O75643
EIAGMQRFGAFYMDY

VPS13B

526

Q7Z7G8
QRFGAFYMDYLYTME

VPS13B

531

Q7Z7G8
VYYMEGRDSMQLIYR

SNAPC4

376

Q5SXM2
GFDAFMTGYVMAYVE

TOE1

441

Q96GM8
VAFMIGMFNLYSYYR

TRPC7

591

Q9HCX4
LRYQREIQGGYMDMY

N4BP3

501

O15049