Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone acetyltransferase binding	KANSL1 MYOCD MED1	7.25e-05	29	56	3	GO:0035035
GeneOntologyMolecularFunction	histone binding	KDM5B BRD2 BAZ1B CHD6 L3MBTL3 PHIP	9.61e-05	265	56	6	GO:0042393
GeneOntologyBiologicalProcess	protein-DNA complex organization	KDM5B MED19 KANSL1 BRD2 SETBP1 BAZ1B FAM47C MYOCD CHD6 REST DOT1L MED1 L3MBTL3	2.02e-06	999	56	13	GO:0071824
GeneOntologyBiologicalProcess	chromatin organization	KDM5B KANSL1 BRD2 SETBP1 BAZ1B FAM47C MYOCD CHD6 REST DOT1L L3MBTL3	2.42e-05	896	56	11	GO:0006325
GeneOntologyBiologicalProcess	chromatin remodeling	KDM5B BRD2 SETBP1 BAZ1B FAM47C MYOCD CHD6 REST DOT1L L3MBTL3	2.69e-05	741	56	10	GO:0006338
GeneOntologyBiologicalProcess	nuclear polyadenylation-dependent rRNA catabolic process	EXOSC9 EXOSC10	1.51e-04	7	56	2	GO:0071035
GeneOntologyBiologicalProcess	TRAMP-dependent tRNA surveillance pathway	EXOSC9 EXOSC10	1.51e-04	7	56	2	GO:0071038
Domain	-	MRTFB MYOCD SF3B2	3.10e-05	21	55	3	1.10.720.30
Domain	SAP	MRTFB MYOCD SF3B2	3.58e-05	22	55	3	PF02037
Domain	SAP	MRTFB MYOCD SF3B2	4.10e-05	23	55	3	SM00513
Domain	LRRC37AB_C	LRRC37A3 LRRC37A2	5.09e-05	4	55	2	PF14914
Domain	K_chnl_volt-dep_Kv3	KCNC2 KCNC3	5.09e-05	4	55	2	IPR003974
Domain	LRRC37_N	LRRC37A3 LRRC37A2	5.09e-05	4	55	2	IPR032754
Domain	LRRC37AB_C	LRRC37A3 LRRC37A2	5.09e-05	4	55	2	IPR029423
Domain	LRRC37	LRRC37A3 LRRC37A2	5.09e-05	4	55	2	PF15779
Domain	LRRC37A/B-like	LRRC37A3 LRRC37A2	5.09e-05	4	55	2	IPR015753
Domain	SAP	MRTFB MYOCD SF3B2	5.31e-05	25	55	3	PS50800
Domain	SAP_dom	MRTFB MYOCD SF3B2	5.31e-05	25	55	3	IPR003034
Domain	Bromodomain_CS	BRD2 BAZ1B PHIP	5.99e-05	26	55	3	IPR018359
Domain	BROMODOMAIN_1	BRD2 BAZ1B PHIP	1.75e-04	37	55	3	PS00633
Domain	RPEL	MRTFB MYOCD	1.77e-04	7	55	2	PS51073
Domain	RPEL	MRTFB MYOCD	1.77e-04	7	55	2	PF02755
Domain	RPEL	MRTFB MYOCD	1.77e-04	7	55	2	SM00707
Domain	RPEL_repeat	MRTFB MYOCD	1.77e-04	7	55	2	IPR004018
Domain	Bromodomain	BRD2 BAZ1B PHIP	1.89e-04	38	55	3	PF00439
Domain	-	IGHMBP2 ZFAND4	2.36e-04	8	55	2	4.10.1110.10
Domain	zf-AN1	IGHMBP2 ZFAND4	2.36e-04	8	55	2	PF01428
Domain	ZF_AN1	IGHMBP2 ZFAND4	2.36e-04	8	55	2	PS51039
Domain	Znf_AN1	IGHMBP2 ZFAND4	2.36e-04	8	55	2	IPR000058
Domain	ZnF_AN1	IGHMBP2 ZFAND4	2.36e-04	8	55	2	SM00154
Domain	BROMODOMAIN_2	BRD2 BAZ1B PHIP	2.38e-04	41	55	3	PS50014
Domain	BROMO	BRD2 BAZ1B PHIP	2.56e-04	42	55	3	SM00297
Domain	Bromodomain	BRD2 BAZ1B PHIP	2.56e-04	42	55	3	IPR001487
Domain	-	BRD2 BAZ1B PHIP	2.56e-04	42	55	3	1.20.920.10
Domain	Ubiquitin	RPS27A ZFAND4	4.60e-04	11	55	2	IPR019956
Domain	-	KDM5B ARID5B	8.72e-04	15	55	2	1.10.150.60
Domain	BRIGHT	KDM5B ARID5B	8.72e-04	15	55	2	SM00501
Domain	ARID_dom	KDM5B ARID5B	8.72e-04	15	55	2	IPR001606
Domain	ARID	KDM5B ARID5B	8.72e-04	15	55	2	PS51011
Domain	ARID	KDM5B ARID5B	8.72e-04	15	55	2	PF01388
Domain	AT_hook	SETBP1 DOT1L	9.95e-04	16	55	2	PF02178
Domain	Apc4_WD40_dom	GEMIN5 WDR53	1.56e-03	20	55	2	IPR024977
Domain	ANAPC4_WD40	GEMIN5 WDR53	1.56e-03	20	55	2	PF12894
Domain	K_chnl_volt-dep_Kv	KCNC2 KCNC3	2.85e-03	27	55	2	IPR003968
Domain	AT_hook	SETBP1 DOT1L	2.85e-03	27	55	2	SM00384
Domain	AT_hook_DNA-bd_motif	SETBP1 DOT1L	2.85e-03	27	55	2	IPR017956
Domain	HMGI/Y_DNA-bd_CS	SETBP1 DOT1L	3.75e-03	31	55	2	IPR000637
Domain	DEXDc	IGHMBP2 CHD6 DHX30	4.07e-03	109	55	3	SM00487
Domain	Helicase_ATP-bd	IGHMBP2 CHD6 DHX30	4.17e-03	110	55	3	IPR014001
Domain	VG_K_chnl	KCNC2 KCNC3	4.24e-03	33	55	2	IPR028325
Domain	DNA/RNA_helicase_DEAH_CS	CHD6 DHX30	4.76e-03	35	55	2	IPR002464
Domain	UBIQUITIN_1	RPS27A ZFAND4	5.31e-03	37	55	2	PS00299
Domain	DEAH_ATP_HELICASE	CHD6 DHX30	5.59e-03	38	55	2	PS00690
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	EXOSC9 EXOSC10 MED19 BRD2 RSL1D1 BAZ1B AFDN GPATCH4 RPS27A MED1 L3MBTL3 PHIP SF3B2	4.63e-09	954	58	13	36373674
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	EXOSC10 KANSL1 BRD2 USP42 RSL1D1 ARID5B BAZ1B GPATCH4 CHD6 RPS27A REST MED1 L3MBTL3 SF3B2	1.99e-08	1294	58	14	30804502
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KANSL1 BRD2 USP42 RSL1D1 BAZ1B GEMIN5 AFDN REST MED1 SF3B2 SPICE1	5.43e-08	774	58	11	15302935
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	KDM5B EXOSC10 AFAP1 BRD2 USP42 MRPL40 CHD6 HS1BP3 RPS27A MED1 SF3B2 DHX30	1.84e-07	1082	58	12	38697112
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EXOSC10 RIOK1 MRTFB RSL1D1 BAZ1B GEMIN5 GPATCH4 RPS27A MED1 SF3B2 DHX30	3.55e-07	934	58	11	33916271
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	EXOSC10 BRD2 RSL1D1 BEND7 BAZ1B GPATCH4 RPS27A SF3B2 DHX30	6.85e-07	605	58	9	28977666
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EXOSC9 MED19 AFAP1 MRTFB BRD2 IGHMBP2 BAZ1B GEMIN5 AFDN GPATCH4 CHD6 MED1 DHX30	8.54e-07	1497	58	13	31527615
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	KDM5B EXOSC9 BRD2 USP42 CHD6 REST L3MBTL3 PHIP	1.09e-06	469	58	8	27634302
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	RIOK1 MED19 BRD2 RSL1D1 CHD6 MED1 L3MBTL3 PHIP SPICE1	1.16e-06	645	58	9	25281560
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	RIOK1 MED19 USP42 RSL1D1 BAZ1B GEMIN5 GPATCH4 CHD6 RPS27A PHIP SF3B2 DHX30	1.48e-06	1318	58	12	30463901
Pubmed	Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA.	KDM5B ARID5B	2.73e-06	2	58	2	11478881
Pubmed	PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome.	EXOSC9 EXOSC10	2.73e-06	2	58	2	14872500
Pubmed	Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells.	EXOSC9 EXOSC10	2.73e-06	2	58	2	16455498
Pubmed	Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs.	KDM5B ARID5B	2.73e-06	2	58	2	11483573
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	EXOSC9 EXOSC10 RSL1D1 IGHMBP2 BAZ1B GPATCH4 MED1 L3MBTL3 DHX30	4.39e-06	759	58	9	35915203
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	EXOSC9 EXOSC10 MRTFB BAZ1B MED1 SF3B2	7.81e-06	283	58	6	30585729
Pubmed	Structure and localization of mouse Pmscl1 and Pmscl2 genes.	EXOSC9 EXOSC10	8.19e-06	3	58	2	10708524
Pubmed	Kv3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons.	KCNC2 KCNC3	8.19e-06	3	58	2	22673617
Pubmed	Myocardin-related transcription factors: critical coactivators regulating cardiovascular development and adaptation.	MRTFB MYOCD	8.19e-06	3	58	2	17363709
Pubmed	Myocardin-related transcription factor contributes to renal fibrosis through the regulation of extracellular microenvironment surrounding fibroblasts.	MRTFB MYOCD	8.19e-06	3	58	2	37289107
Pubmed	Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1.	KCNC2 KCNC3	8.19e-06	3	58	2	1740329
Pubmed	Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.	AFDN DOT1L	8.19e-06	3	58	2	23361907
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	EXOSC10 BRD2 RSL1D1 BAZ1B GEMIN5 RPS27A SF3B2 DHX30	1.09e-05	641	58	8	36057605
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	EXOSC10 RSL1D1 BAZ1B GEMIN5 AFDN PHIP SF3B2 DHX30	1.24e-05	653	58	8	22586326
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	RSL1D1 GEMIN5 GPATCH4 CHD6 RPS27A SF3B2 DHX30 SPICE1	1.27e-05	655	58	8	35819319
Pubmed	STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.	EXOSC10 RIOK1 RSL1D1 IGHMBP2 GPATCH4 DHX30	1.46e-05	316	58	6	31665637
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	EXOSC10 RIOK1 RSL1D1 GEMIN5 GPATCH4 RPS27A SF3B2 DHX30	1.63e-05	678	58	8	30209976
Pubmed	The histone demethylase, Jmjd1a, interacts with the myocardin factors to regulate SMC differentiation marker gene expression.	MRTFB MYOCD	1.64e-05	4	58	2	17991879
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A3 LRRC37A2	1.64e-05	4	58	2	22419166
Pubmed	Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease.	KCNC2 KCNC3	1.64e-05	4	58	2	21912965
Pubmed	Potentiation of serum response factor activity by a family of myocardin-related transcription factors.	MRTFB MYOCD	1.64e-05	4	58	2	12397177
Pubmed	Localization of Shaw-related K+ channel genes on mouse and human chromosomes.	KCNC2 KCNC3	1.64e-05	4	58	2	8111118
Pubmed	Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation.	MRTFB MYOCD	1.64e-05	4	58	2	16204380
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	RSL1D1 BAZ1B GPATCH4 PHIP SF3B2 DHX30	1.86e-05	330	58	6	33301849
Pubmed	Tagging genes with cassette-exchange sites.	KDM5B BAZ1B GEMIN5 AFDN REST DHX30	2.03e-05	335	58	6	15741177
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	KDM5B BRD2 IGHMBP2 BAZ1B AFDN REST ZFAND4 PHIP	2.24e-05	709	58	8	22988430
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	EXOSC9 EXOSC10 RSL1D1 GEMIN5 MRPL40 GPATCH4 SF3B2 DHX30	2.33e-05	713	58	8	29802200
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	EXOSC10 RSL1D1 BAZ1B GPATCH4 PHIP DHX30	2.55e-05	349	58	6	25665578
Pubmed	Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein.	BRD2 MED1	2.72e-05	5	58	2	12145330
Pubmed	Thymine DNA glycosylase represses myocardin-induced smooth muscle cell differentiation by competing with serum response factor for myocardin binding.	MRTFB MYOCD	2.72e-05	5	58	2	18945672
Pubmed	Brain dopamine receptor plasticity: testing a diathesis-stress hypothesis in an animal model.	KCNC2 KCNC3	2.72e-05	5	58	2	9266612
Pubmed	Muscle-specific signaling mechanism that links actin dynamics to serum response factor.	MRTFB MYOCD	2.72e-05	5	58	2	15798203
Pubmed	Frap, FKBP12 rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene.	EXOSC9 EXOSC10	2.72e-05	5	58	2	14634209
Pubmed	Steroid receptor coactivator 3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation.	MRTFB MYOCD	2.72e-05	5	58	2	17360478
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	CHD6 RPS27A PHIP DHX30	3.40e-05	109	58	4	33554859
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	EXOSC10 MRTFB BAZ1B GEMIN5 AFDN DOT1L MED1	3.52e-05	549	58	7	38280479
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	EXOSC9 EXOSC10 BRD2 USP42 RSL1D1 BAZ1B RPS27A SF3B2 DHX30	3.58e-05	989	58	9	36424410
Pubmed	Nuclear organization of nucleotide excision repair is mediated by RING1B dependent H2A-ubiquitylation.	EXOSC10 RSL1D1 SF3B2 DHX30	3.78e-05	112	58	4	28416769
Pubmed	Genetics of rheumatoid arthritis contributes to biology and drug discovery.	CD40 ARID5B MED1 CEP57	3.78e-05	112	58	4	24390342
Pubmed	The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases.	EXOSC9 EXOSC10	4.08e-05	6	58	2	10465791
Pubmed	C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing.	EXOSC9 EXOSC10	4.08e-05	6	58	2	17412707
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	EXOSC9 EXOSC10 BRD2 RSL1D1 BAZ1B AFDN PHIP SF3B2 DHX30	4.68e-05	1024	58	9	24711643
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	KDM5B EXOSC9 BRD2 RSL1D1 ARID5B AFDN CHD6 RPS27A SF3B2 DHX30	4.75e-05	1285	58	10	35914814
Pubmed	Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways.	EXOSC9 EXOSC10	5.71e-05	7	58	2	17545563
Pubmed	DNA-binding properties of ARID family proteins.	KDM5B ARID5B	5.71e-05	7	58	2	15640446
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	EXOSC10 BRD2 RSL1D1 BAZ1B GPATCH4 SF3B2 DHX30	6.23e-05	601	58	7	33658012
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	BRD2 BAZ1B GPATCH4 CHD6 DOT1L MED1 PHIP	6.70e-05	608	58	7	36089195
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	KDM5B MRTFB ARID5B GEMIN5 CHD6 L3MBTL3	6.94e-05	418	58	6	34709266
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	EXOSC10 KANSL1 RSL1D1 BAZ1B GEMIN5 AFDN GPATCH4 PHIP SF3B2 DHX30	7.30e-05	1353	58	10	29467282
Pubmed	WSTF acetylation by MOF promotes WSTF activities and oncogenic functions.	KANSL1 BAZ1B	7.60e-05	8	58	2	32518374
Pubmed	Autoantibodies directed to novel components of the PM/Scl complex, the human exosome.	EXOSC9 EXOSC10	7.60e-05	8	58	2	11879549
Pubmed	RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.	EXOSC10 RIOK1 RSL1D1 RPS27A SF3B2 DHX30	7.61e-05	425	58	6	21081503
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	EXOSC9 EXOSC10 RSL1D1 BAZ1B GPATCH4 DOT1L SF3B2 DHX30	7.82e-05	847	58	8	35850772
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	EXOSC9 EXOSC10 RSL1D1 GEMIN5 MED1 DHX30	9.20e-05	440	58	6	34244565
Pubmed	Nuclear Functions of Nucleolin through Global Proteomics and Interactomic Approaches.	EXOSC9 EXOSC10 RSL1D1 DHX30	1.03e-04	145	58	4	27049334
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	EXOSC9 RIOK1 RSL1D1 BAZ1B GEMIN5 AFDN GPATCH4 PHIP SF3B2 DHX30	1.12e-04	1425	58	10	30948266
Pubmed	Human transcription factor protein interaction networks.	KANSL1 BRD2 RSL1D1 ARID5B BAZ1B GPATCH4 CHD6 DOT1L L3MBTL3 DHX30	1.15e-04	1429	58	10	35140242
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	RSL1D1 GEMIN5 MRPL40 CHD6 RPS27A REST MED1 SF3B2 DHX30	1.16e-04	1153	58	9	29845934
Pubmed	Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.	EXOSC9 EXOSC10	1.22e-04	10	58	2	36241425
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A3 LRRC37A2	1.22e-04	10	58	2	23064749
Pubmed	The functional interactome landscape of the human histone deacetylase family.	ARID5B BAZ1B CEP57 PHIP SF3B2	1.22e-04	289	58	5	23752268
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	EXOSC10 KANSL1 RSL1D1 CHD6 PHIP DHX30	1.40e-04	475	58	6	31040226
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	KDM5B BAZ1B CHD6 REST	1.40e-04	157	58	4	30186101
Pubmed	Reconstitution, activities, and structure of the eukaryotic RNA exosome.	EXOSC9 EXOSC10	1.49e-04	11	58	2	17174896
Pubmed	The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus.	EXOSC9 EXOSC10	1.49e-04	11	58	2	12788944
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	EXOSC9 EXOSC10 RSL1D1 GPATCH4 RPS27A DHX30	1.53e-04	483	58	6	36912080
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	EXOSC9 EXOSC10 RSL1D1 IGHMBP2 GPATCH4 DHX30	1.58e-04	486	58	6	30940648
Pubmed	Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.	EXOSC9 EXOSC10	1.78e-04	12	58	2	12419256
Pubmed	A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction.	MED19 MED1	1.78e-04	12	58	2	23563140
Pubmed	Three novel components of the human exosome.	EXOSC9 EXOSC10	1.78e-04	12	58	2	11110791
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	USP42 RSL1D1 RPS27A MED1 SRRM3 SF3B2 DHX30	1.95e-04	723	58	7	34133714
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	EXOSC9 RIOK1 KANSL1 RSL1D1 BAZ1B MRPL40 SF3B2 DHX30	2.00e-04	971	58	8	33306668
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	EXOSC9 EXOSC10 RSL1D1 GPATCH4 RPS27A SF3B2 DHX30	2.09e-04	731	58	7	29298432
Pubmed	Serum Response Factor Is Essential for Maintenance of Podocyte Structure and Function.	MRTFB MYOCD	2.11e-04	13	58	2	29114040
Pubmed	Protein-protein interactions of hCsl4p with other human exosome subunits.	EXOSC9 EXOSC10	2.11e-04	13	58	2	11812149
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KDM5B KANSL1	2.11e-04	13	58	2	21502505
Pubmed	Dis3-like 1: a novel exoribonuclease associated with the human exosome.	EXOSC9 EXOSC10	2.11e-04	13	58	2	20531389
Pubmed	The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.	EXOSC9 EXOSC10	2.11e-04	13	58	2	21255825
Pubmed	Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding.	BAZ1B RPS27A SF3B2	2.42e-04	72	58	3	31248990
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	EXOSC10 BRD2 RSL1D1 L3MBTL3 SF3B2	2.56e-04	339	58	5	30415952
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	MRTFB RSL1D1 BAZ1B MED1 SF3B2	2.63e-04	341	58	5	32971831
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	BRD2 BAZ1B PHIP	2.73e-04	75	58	3	25593309
Pubmed	A protein interaction framework for human mRNA degradation.	EXOSC9 EXOSC10 IGHMBP2 MRPL40 DHX30	2.85e-04	347	58	5	15231747
Pubmed	Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF).	EXOSC10 RSL1D1 BAZ1B DHX30	2.97e-04	191	58	4	21907836
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	EXOSC9 EXOSC10 RIOK1 RPS27A SF3B2 DHX30	3.10e-04	551	58	6	34728620
Pubmed	Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression.	MRTFB MYOCD	3.66e-04	17	58	2	21704027
Pubmed	Exosome complex components 1 and 2 are vital for early mammalian development.	EXOSC9 EXOSC10	4.11e-04	18	58	2	37940010
Pubmed	AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.	EXOSC9 EXOSC10	4.11e-04	18	58	2	11719186
Pubmed	The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L.	EXOSC9 EXOSC10	4.11e-04	18	58	2	20531386
Pubmed	Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse.	REST SRRM3	4.11e-04	18	58	2	33087486
Interaction	LYAR interactions	RIOK1 BRD2 RSL1D1 BEND7 BAZ1B GPATCH4 REST DOT1L DHX30	9.51e-07	373	57	9	int:LYAR
Interaction	CHD3 interactions	KDM5B RIOK1 BRD2 RSL1D1 BEND7 BAZ1B GPATCH4 CHD6 RPS27A DOT1L SF3B2 DHX30	1.08e-06	757	57	12	int:CHD3
Interaction	SMC5 interactions	EXOSC9 EXOSC10 MED19 BRD2 RSL1D1 BAZ1B AFDN GPATCH4 RPS27A MED1 L3MBTL3 PHIP SF3B2	3.27e-06	1000	57	13	int:SMC5
Interaction	ZNF330 interactions	EXOSC9 EXOSC10 RIOK1 BRD2 RSL1D1 BAZ1B GPATCH4 L3MBTL3 PHIP	4.12e-06	446	57	9	int:ZNF330
Interaction	H2BC8 interactions	EXOSC9 EXOSC10 RIOK1 BRD2 ARID5B BAZ1B GPATCH4 CHD6 L3MBTL3 PHIP	4.34e-06	576	57	10	int:H2BC8
Interaction	MEN1 interactions	EXOSC9 EXOSC10 MRTFB KANSL1 RSL1D1 SETBP1 BAZ1B AFDN GPATCH4 DOT1L MED1 SF3B2 DHX30	4.47e-06	1029	57	13	int:MEN1
Interaction	NOL12 interactions	BRD2 RSL1D1 BEND7 GPATCH4 DOT1L SF3B2	4.58e-06	153	57	6	int:NOL12
Interaction	RPS16 interactions	EXOSC9 EXOSC10 RIOK1 RSL1D1 GEMIN5 RPS27A REST DOT1L CEP57 SF3B2 DHX30	4.87e-06	724	57	11	int:RPS16
Interaction	H3C1 interactions	EXOSC9 EXOSC10 RIOK1 BRD2 RSL1D1 BAZ1B MYH15 GPATCH4 RPS27A L3MBTL3 PHIP SF3B2	6.53e-06	901	57	12	int:H3C1
Interaction	FBL interactions	EXOSC10 RIOK1 RSL1D1 CD40 BAZ1B GPATCH4 REST DOT1L PHIP DHX30	1.08e-05	639	57	10	int:FBL
Interaction	NSD2 interactions	BRD2 RSL1D1 BAZ1B GEMIN5 GPATCH4 RPS27A SF3B2	1.29e-05	278	57	7	int:NSD2
Interaction	DNAJC9 interactions	EXOSC10 RIOK1 BRD2 RSL1D1 BAZ1B RPS27A DOT1L	1.94e-05	296	57	7	int:DNAJC9
Interaction	TTN interactions	EXOSC10 BRD2 RSL1D1 AFDN RPS27A CEP57 TRDN	2.07e-05	299	57	7	int:TTN
Interaction	H2BC21 interactions	KDM5B RIOK1 MRTFB BRD2 USP42 BAZ1B RPS27A REST L3MBTL3 PHIP	2.25e-05	696	57	10	int:H2BC21
Interaction	RPL35 interactions	RIOK1 RSL1D1 MRPL40 GPATCH4 RPS27A REST DOT1L SF3B2 DHX30	2.47e-05	558	57	9	int:RPL35
Interaction	NR2C2 interactions	RIOK1 MED19 USP42 RSL1D1 BAZ1B GEMIN5 AFDN GPATCH4 CHD6 RPS27A DOT1L PHIP SF3B2 DHX30	2.65e-05	1403	57	14	int:NR2C2
Interaction	KMT2A interactions	KDM5B KANSL1 SETBP1 GEMIN5 AFDN RPS27A DOT1L	2.83e-05	314	57	7	int:KMT2A
Interaction	RPS6 interactions	EXOSC10 RIOK1 RSL1D1 MRPL40 GPATCH4 CHD6 RPS27A REST DOT1L PHIP DHX30	2.84e-05	874	57	11	int:RPS6
Interaction	RPL18A interactions	EXOSC10 RIOK1 RSL1D1 GPATCH4 RPS27A REST DOT1L DHX30	3.51e-05	447	57	8	int:RPL18A
Interaction	HDAC4 interactions	KDM5B EXOSC10 KANSL1 RSL1D1 MYOCD CHD6 RPS27A REST PHIP DHX30	3.97e-05	744	57	10	int:HDAC4
Interaction	TENT4B interactions	EXOSC10 GPATCH4 CHD6 DOT1L SF3B2	4.40e-05	138	57	5	int:TENT4B
Interaction	RPL5 interactions	EXOSC9 EXOSC10 RIOK1 RSL1D1 IGHMBP2 RPS27A REST DOT1L DHX30	4.70e-05	606	57	9	int:RPL5
Interaction	RPL30 interactions	RIOK1 RSL1D1 GPATCH4 RPS27A REST DOT1L CEP57 DHX30	5.31e-05	474	57	8	int:RPL30
Interaction	KDM1A interactions	KDM5B RIOK1 MRTFB KANSL1 ARID5B GEMIN5 CHD6 CEP57 L3MBTL3 SF3B2 SPICE1	5.56e-05	941	57	11	int:KDM1A
Interaction	RCOR1 interactions	KDM5B MRTFB ARID5B GEMIN5 CHD6 REST L3MBTL3 PHIP	7.09e-05	494	57	8	int:RCOR1
Interaction	ZCCHC8 interactions	EXOSC9 EXOSC10 RIOK1 DOT1L SF3B2	7.42e-05	154	57	5	int:ZCCHC8
Interaction	NAA40 interactions	EXOSC10 RIOK1 MRTFB RSL1D1 BAZ1B GEMIN5 GPATCH4 RPS27A MED1 SF3B2 DHX30	7.87e-05	978	57	11	int:NAA40
Interaction	H2AZ1 interactions	RIOK1 KANSL1 BRD2 ARID5B BAZ1B MYH15 PHIP	8.11e-05	371	57	7	int:H2AZ1
Interaction	RPL11 interactions	RIOK1 USP42 RSL1D1 GPATCH4 RPS27A REST DOT1L CEP57 DHX30	8.25e-05	652	57	9	int:RPL11
Interaction	CENPA interactions	BRD2 BAZ1B GPATCH4 CHD6 DOT1L L3MBTL3 PHIP	8.97e-05	377	57	7	int:CENPA
Interaction	KRR1 interactions	RIOK1 RSL1D1 BAZ1B RPS27A DOT1L SF3B2 DHX30	9.27e-05	379	57	7	int:KRR1
Interaction	REXO4 interactions	RIOK1 RSL1D1 BAZ1B DOT1L SF3B2 DHX30	9.30e-05	261	57	6	int:REXO4
Interaction	SRSF3 interactions	RIOK1 RSL1D1 GEMIN5 MRPL40 REST DOT1L SF3B2 DHX30	1.04e-04	522	57	8	int:SRSF3
Interaction	GRWD1 interactions	EXOSC10 RIOK1 RSL1D1 DOT1L CEP57 SF3B2 DHX30	1.11e-04	390	57	7	int:GRWD1
Interaction	FBXW7 interactions	EXOSC10 RIOK1 MED19 BRD2 RSL1D1 BAZ1B GPATCH4 CHD6 REST MED1 SF3B2 DHX30	1.23e-04	1215	57	12	int:FBXW7
Interaction	COIL interactions	RIOK1 BRD2 RSL1D1 GPATCH4 CHD6 DOT1L L3MBTL3 DHX30	1.53e-04	552	57	8	int:COIL
Interaction	IFI16 interactions	EXOSC10 RIOK1 RSL1D1 IGHMBP2 BAZ1B GPATCH4 DOT1L PHIP DHX30	1.64e-04	714	57	9	int:IFI16
Interaction	DDX21 interactions	RIOK1 RSL1D1 BAZ1B GEMIN5 GPATCH4 RPS27A REST DOT1L DHX30	1.71e-04	718	57	9	int:DDX21
Interaction	SNRPN interactions	RIOK1 GEMIN5 REST DOT1L SF3B2	1.80e-04	186	57	5	int:SNRPN
Interaction	ABT1 interactions	RIOK1 RSL1D1 IGHMBP2 GPATCH4 DOT1L SRRM3 DHX30	1.83e-04	423	57	7	int:ABT1
Interaction	RPS10 interactions	RIOK1 RSL1D1 BAZ1B RPS27A REST DOT1L SF3B2 DHX30	1.83e-04	567	57	8	int:RPS10
Interaction	SURF6 interactions	RIOK1 RSL1D1 IGHMBP2 GPATCH4 DOT1L SF3B2 DHX30	1.91e-04	426	57	7	int:SURF6
Interaction	SRSF4 interactions	RIOK1 USP42 RSL1D1 MRPL40 DOT1L SF3B2	1.99e-04	300	57	6	int:SRSF4
Interaction	UTP23 interactions	BRD2 RSL1D1 BAZ1B GPATCH4 SF3B2	2.04e-04	191	57	5	int:UTP23
Interaction	MECP2 interactions	KDM5B EXOSC10 AFAP1 BRD2 USP42 MRPL40 CHD6 HS1BP3 RPS27A MED1 SF3B2 DHX30	2.11e-04	1287	57	12	int:MECP2
Interaction	SUMO1P1 interactions	SETBP1 L3MBTL3 FAM118B	2.12e-04	41	57	3	int:SUMO1P1
Interaction	SNRPE interactions	RIOK1 BRD2 GEMIN5 REST DOT1L SF3B2	2.17e-04	305	57	6	int:SNRPE
Interaction	ZNF354A interactions	RSL1D1 MYOCD GPATCH4	2.28e-04	42	57	3	int:ZNF354A
Interaction	SUPT16H interactions	RIOK1 BRD2 RSL1D1 BAZ1B MED1 PHIP SPICE1	2.39e-04	442	57	7	int:SUPT16H
Interaction	CHD4 interactions	EXOSC10 BRD2 RSL1D1 BAZ1B GEMIN5 RPS27A DOT1L PHIP SF3B2 DHX30	2.68e-04	938	57	10	int:CHD4
Interaction	RPL7L1 interactions	RIOK1 RSL1D1 BAZ1B GPATCH4 DOT1L	2.70e-04	203	57	5	int:RPL7L1
Interaction	RPL4 interactions	EXOSC10 RIOK1 RSL1D1 BEND7 GEMIN5 GPATCH4 RPS27A REST DHX30	2.71e-04	764	57	9	int:RPL4
Interaction	PSIP1 interactions	BRD2 IGHMBP2 SETBP1 REST DOT1L	2.83e-04	205	57	5	int:PSIP1
Interaction	EXOSC1 interactions	EXOSC9 EXOSC10 BAZ1B DOT1L	2.85e-04	112	57	4	int:EXOSC1
Interaction	RUVBL2 interactions	EXOSC10 RIOK1 BRD2 IGHMBP2 GEMIN5 RPS27A REST DOT1L	3.21e-04	616	57	8	int:RUVBL2
Interaction	RPS7 interactions	RIOK1 RSL1D1 RPS27A REST DOT1L CEP57 SF3B2	3.29e-04	466	57	7	int:RPS7
Interaction	SRSF5 interactions	RIOK1 RSL1D1 BEND7 REST DOT1L SF3B2 DHX30	3.65e-04	474	57	7	int:SRSF5
Interaction	HECTD1 interactions	EXOSC9 EXOSC10 MED19 RSL1D1 IGHMBP2 BAZ1B GPATCH4 MED1 L3MBTL3 DHX30	3.92e-04	984	57	10	int:HECTD1
Interaction	BRD7 interactions	EXOSC9 EXOSC10 BRD2 RSL1D1 IGHMBP2 GEMIN5 GPATCH4 DHX30	4.02e-04	637	57	8	int:BRD7
Interaction	RPL19 interactions	RIOK1 RSL1D1 MRPL40 RPS27A REST DOT1L SF3B2 DHX30	4.06e-04	638	57	8	int:RPL19
Interaction	MTF1 interactions	EXOSC10 RSL1D1 SF3B2 DHX30	4.06e-04	123	57	4	int:MTF1
Interaction	HBP1 interactions	RSL1D1 BAZ1B PHIP DHX30	4.06e-04	123	57	4	int:HBP1
Interaction	RNF151 interactions	RSL1D1 GPATCH4 SF3B2 DHX30	4.06e-04	123	57	4	int:RNF151
Interaction	POLR2H interactions	MED19 CD40 DOT1L MED1 CEP57	4.16e-04	223	57	5	int:POLR2H
Interaction	SRSF9 interactions	RIOK1 BRD2 REST DOT1L SF3B2	4.24e-04	224	57	5	int:SRSF9
Interaction	SUZ12 interactions	BRD2 USP42 RSL1D1 REST CEP57 L3MBTL3 SF3B2 DHX30	4.32e-04	644	57	8	int:SUZ12
Interaction	ADARB1 interactions	EXOSC10 RSL1D1 BEND7 RPS27A MED1 SF3B2 DHX30	4.39e-04	489	57	7	int:ADARB1
Interaction	RBM7 interactions	EXOSC9 EXOSC10 DOT1L SF3B2	4.45e-04	126	57	4	int:RBM7
Interaction	RPS8 interactions	RIOK1 RSL1D1 MRPL40 GPATCH4 RPS27A REST DOT1L SF3B2	4.55e-04	649	57	8	int:RPS8
Interaction	H3C3 interactions	RIOK1 BRD2 BAZ1B GPATCH4 CHD6 MED1 PHIP	4.73e-04	495	57	7	int:H3C3
Interaction	DAXX interactions	BRD2 RSL1D1 BAZ1B GPATCH4 DOT1L SF3B2	4.73e-04	353	57	6	int:DAXX
Interaction	H1-4 interactions	RIOK1 BRD2 RSL1D1 BAZ1B RPS27A DOT1L SF3B2 DHX30	4.88e-04	656	57	8	int:H1-4
Interaction	RPS2 interactions	RIOK1 RSL1D1 BAZ1B RPS27A REST DOT1L SF3B2 DHX30	4.93e-04	657	57	8	int:RPS2
Interaction	GPATCH4 interactions	BRD2 RSL1D1 GPATCH4 DOT1L DHX30	4.98e-04	232	57	5	int:GPATCH4
Interaction	H2AC17 interactions	ARID5B BAZ1B MRPL40 GPATCH4 DHX30	4.98e-04	232	57	5	int:H2AC17
Interaction	PRR11 interactions	RSL1D1 GPATCH4 SF3B2 DHX30	5.01e-04	130	57	4	int:PRR11
Interaction	PYHIN1 interactions	EXOSC9 EXOSC10 RSL1D1 BAZ1B PHIP SF3B2	5.10e-04	358	57	6	int:PYHIN1
Interaction	SOX2 interactions	KDM5B EXOSC9 EXOSC10 RSL1D1 KSR2 ARID5B BAZ1B CHD6 RPS27A MED1 L3MBTL3 DHX30	5.25e-04	1422	57	12	int:SOX2
Interaction	C1D interactions	EXOSC9 EXOSC10 DOT1L	5.35e-04	56	57	3	int:C1D
Interaction	H1-2 interactions	RIOK1 BRD2 RSL1D1 BAZ1B MRPL40 RPS27A REST DOT1L	5.39e-04	666	57	8	int:H1-2
Interaction	HNRNPU interactions	EXOSC10 RIOK1 RSL1D1 IGHMBP2 BAZ1B MRPL40 REST DOT1L CEP57 DHX30	5.83e-04	1035	57	10	int:HNRNPU
Interaction	PSPC1 interactions	EXOSC9 EXOSC10 RSL1D1 GEMIN5 DOT1L SF3B2 DHX30	5.98e-04	515	57	7	int:PSPC1
Interaction	RC3H1 interactions	EXOSC10 RIOK1 RSL1D1 GEMIN5 GPATCH4 RPS27A SF3B2 DHX30	6.01e-04	677	57	8	int:RC3H1
Interaction	RPL7A interactions	RIOK1 RSL1D1 GPATCH4 RPS27A REST TRDN SF3B2 DHX30	6.13e-04	679	57	8	int:RPL7A
Interaction	RPL31 interactions	EXOSC9 EXOSC10 RIOK1 BRD2 RSL1D1 GPATCH4 RPS27A REST	6.19e-04	680	57	8	int:RPL31
Interaction	TOP2A interactions	BRD2 BAZ1B DOT1L L3MBTL3 SF3B2 DHX30 SPICE1	6.33e-04	520	57	7	int:TOP2A
Interaction	SSRP1 interactions	EXOSC10 BRD2 RSL1D1 GEMIN5 DOT1L PHIP FAM118B SPICE1	6.49e-04	685	57	8	int:SSRP1
Interaction	GEMIN8 interactions	CD40 GEMIN5 DOT1L	6.87e-04	61	57	3	int:GEMIN8
Interaction	RNF113A interactions	RSL1D1 GEMIN5 GPATCH4 CHD6 RPS27A SF3B2 DHX30 SPICE1	6.94e-04	692	57	8	int:RNF113A
Interaction	ZBTB47 interactions	RSL1D1 BEND7 SF3B2 DHX30	7.36e-04	144	57	4	int:ZBTB47
Interaction	RPL13 interactions	RIOK1 RSL1D1 BEND7 MRPL40 GPATCH4 RPS27A REST DHX30	7.48e-04	700	57	8	int:RPL13
Interaction	RPL10 interactions	RIOK1 BAZ1B MRPL40 GPATCH4 RPS27A REST PHIP DHX30	7.62e-04	702	57	8	int:RPL10
Interaction	GIGYF2 interactions	EXOSC9 EXOSC10 DOT1L CEP57 SF3B2	8.77e-04	263	57	5	int:GIGYF2
Interaction	OBSL1 interactions	EXOSC9 EXOSC10 BRD2 RSL1D1 BAZ1B AFDN PHIP SF3B2 DHX30	9.02e-04	902	57	9	int:OBSL1
Interaction	RPL3 interactions	RIOK1 RSL1D1 GPATCH4 RPS27A REST DOT1L SF3B2 DHX30	9.14e-04	722	57	8	int:RPL3
Interaction	KCNC1 interactions	KCNC2 KCNC3	9.19e-04	16	57	2	int:KCNC1
Interaction	TOP2B interactions	BRD2 BAZ1B GPATCH4 DOT1L SPICE1	9.23e-04	266	57	5	int:TOP2B
Interaction	RPS15A interactions	RIOK1 RSL1D1 RPS27A REST DOT1L CEP57	9.45e-04	403	57	6	int:RPS15A
Interaction	HMGN5 interactions	KDM5B BAZ1B RPS27A PHIP	9.46e-04	154	57	4	int:HMGN5
Interaction	HDAC1 interactions	KDM5B RIOK1 MRTFB ARID5B GEMIN5 RPS27A REST DOT1L L3MBTL3 SF3B2	9.86e-04	1108	57	10	int:HDAC1
GeneFamily	Zinc fingers AN1-type\|UPF1 like RNA helicases	IGHMBP2 ZFAND4	8.98e-05	8	33	2	63
GeneFamily	Exosome complex	EXOSC9 EXOSC10	2.11e-04	12	33	2	817
GeneFamily	AT-rich interaction domain containing	KDM5B ARID5B	3.34e-04	15	33	2	418
GeneFamily	Cyclins\|Mediator complex	MED19 MED1	1.65e-03	33	33	2	1061
GeneFamily	Potassium voltage-gated channels	KCNC2 KCNC3	2.41e-03	40	33	2	274
GeneFamily	PHD finger proteins	KDM5B BAZ1B	1.17e-02	90	33	2	88
GeneFamily	WD repeat domain containing	GEMIN5 PHIP WDR53	1.19e-02	262	33	3	362
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MRTFB KCNC2 SETBP1 KSR2 SRRM3	5.66e-06	196	58	5	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MRTFB KCNC2 SETBP1 KSR2 SRRM3	5.95e-06	198	58	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MRTFB KCNC2 SETBP1 KSR2 SRRM3	5.95e-06	198	58	5	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MRTFB KCNC2 SETBP1 KSR2 SRRM3	5.95e-06	198	58	5	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	MRTFB KCNC2 SETBP1 KSR2 SRRM3	6.25e-06	200	58	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	367C-Myeloid-Monocyte-CD16+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SLCO5A1 LRRC37A2 GEMIN5 HS1BP3	6.19e-05	164	58	4	1aff83fc73b4e41e6f0d4b04dbca153bcc7a3518
ToppCell	367C-Myeloid-Monocyte-CD16+_Monocyte\|Monocyte / Donor, Lineage, Cell class and subclass (all cells)	SLCO5A1 LRRC37A2 GEMIN5 HS1BP3	7.45e-05	172	58	4	fb8ab2576b5c38db63573a3bf46b8d9d634c4999
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet-Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNC3 SETBP1 KSR2 DOT1L	8.32e-05	177	58	4	e1e45956887371b1c18f1eb479dd930031497520
ToppCell	Control_saline-Hematopoietic_Myeloid-Dendritic_cells-mDC\|Control_saline / Treatment groups by lineage, cell group, cell type	SLCO5A1 CD40 DOT1L FAM118B	9.07e-05	181	58	4	818ac31a718e9b29feb4c4eecbc339e6af45254a
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RIOK1 SETBP1 CD40 AFDN	1.09e-04	190	58	4	0db545a4cba7534bad2693e0d565cde7dbc7a586
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	KCNC2 KSR2 PTCHD4 SRRM3	1.12e-04	191	58	4	5d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCell	Entopeduncular-Neuronal-Inhibitory\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	KCNC2 KSR2 PTCHD4 SRRM3	1.12e-04	191	58	4	73dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	KANSL1 AFDN CHD6 PHIP	1.14e-04	192	58	4	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-B_mem-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SETBP1 CD40 ARID5B RPS27A	1.14e-04	192	58	4	185dd150d3345cd29625052a46f3ed89f2a9a8f6
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-B_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SETBP1 CD40 ARID5B RPS27A	1.14e-04	192	58	4	0bda96d8f223e8fa9caf935079ab202fc5c812ee
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-IPC_like\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	SLCO5A1 ARID5B AFDN RPS27A	1.16e-04	193	58	4	f24bae40f5cbcfece04fbefe4e3de1b88ac90de4
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-B_lymphocytic\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SETBP1 CD40 ARID5B RPS27A	1.16e-04	193	58	4	ddc06227f2580774d9f34729dff912d6a9155f9c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SETBP1 CD40 ARID5B AFDN	1.16e-04	193	58	4	9f798a1bbd9f076c3122d02ed28418c18bb7a369
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	KANSL1 AFDN CHD6 PHIP	1.16e-04	193	58	4	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-IPC_like-IPCs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	SLCO5A1 ARID5B AFDN RPS27A	1.16e-04	193	58	4	2088f1d210c73f74685492c63065c62ac3f553e9
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-B_mem\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SETBP1 CD40 ARID5B RPS27A	1.19e-04	194	58	4	9657aef9f11d02d2f0e5cd4b4d8ba23eb2750d92
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-IPC_like-IPCs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	SLCO5A1 ARID5B AFDN RPS27A	1.21e-04	195	58	4	da8680a91648843901e456b5faef5e85039ade15
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-B_mem-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SETBP1 CD40 ARID5B RPS27A	1.21e-04	195	58	4	a4a3dc54b88bcdd82966ee0d5f7be00f227f5457
ToppCell	severe_COVID-19-B_memory\|severe_COVID-19 / disease group, cell group and cell class (v2)	SETBP1 CD40 ARID5B AFDN	1.23e-04	196	58	4	c6e00cb59a88b9903cca233cefe05f80c5ea4153
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MRTFB SETBP1 KSR2 SRRM3	1.28e-04	198	58	4	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KCNC2 SETBP1 KSR2 SRRM3	1.28e-04	198	58	4	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Striatum-Macroglia-ASTROCYTE-Gja1-Sparc-Astrocyte.Gja1.Sparc-Car2_(Car2)-\|Striatum / BrainAtlas - Mouse McCarroll V32	FAM47C MYH15 PKD1L3	1.29e-04	75	58	3	162b69b9934da4623ee378b0e8206c4e4917351b
ToppCell	Striatum-Macroglia-ASTROCYTE-Gja1-Sparc-Astrocyte.Gja1.Sparc-Car2_(Car2)\|Striatum / BrainAtlas - Mouse McCarroll V32	FAM47C MYH15 PKD1L3	1.29e-04	75	58	3	98807389b7735b90024ba5e71be60cf95416c077
ToppCell	Striatum-Macroglia-ASTROCYTE-Gja1-Sparc\|Striatum / BrainAtlas - Mouse McCarroll V32	FAM47C MYH15 PKD1L3	1.29e-04	75	58	3	15505f3e7a25b3ae51f0917335e92d6279e6d06d
ToppCell	Sepsis-Int-URO-Lymphocyte-B-B_memory\|Int-URO / Disease, condition lineage and cell class	SLCO5A1 CD40 ARID5B RPS27A	1.31e-04	199	58	4	7cddf15aeb65df17f737bb3144d6579ec5a1ea27
ToppCell	Neuronal-Inhibitory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	AFAP1 KCNC2 PTCHD4 ZFAND4	1.33e-04	200	58	4	9ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCell	Sepsis-Bac-SEP-Lymphocyte-B-B_memory\|Bac-SEP / Disease, condition lineage and cell class	SETBP1 CD40 ARID5B RPS27A	1.33e-04	200	58	4	7578fc9b6b8519a04c4c08fdfd3224b3df8057a2
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Neuronal-Neuron\|2m / Sample Type, Dataset, Time_group, and Cell type.	SLCO5A1 KDM5B AFAP1 AFDN	1.33e-04	200	58	4	a581f1704a87b0390e1e2ff85053367d85247755
Disease	B-cell lymphoma (is_implicated_in)	BRD2 CD40	7.12e-05	7	55	2	DOID:707 (is_implicated_in)
Disease	dilated cardiomyopathy (implicated_via_orthology)	MYH15 MYOCD MED1	4.55e-04	80	55	3	DOID:12930 (implicated_via_orthology)
Disease	systemic lupus erythematosus	KSR2 CD40 ARID5B STMND1 DOT1L MED1 L3MBTL3	6.81e-04	799	55	7	MONDO_0007915
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	KCNC2 BEND7 STIMATE SETBP1 CD40 ARID5B REST	6.92e-04	801	55	7	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	reaction time measurement	KANSL1 KCNC2 LRRC37A2 ARID5B MYH15 CHD6	1.38e-03	658	55	6	EFO_0008393
Disease	apolipoprotein B measurement	BAZ1B HS1BP3 PKD1L3 SRRM3 L3MBTL3 FAM118B	1.43e-03	663	55	6	EFO_0004615
Disease	bowel opening frequency	SNX24 MRPL40	1.44e-03	30	55	2	EFO_0600084
Disease	vital capacity	KANSL1 SNX24 ARID5B DOT1L MED1 PKD1L3 L3MBTL3 SF3B2	1.96e-03	1236	55	8	EFO_0004312
Disease	Mental Retardation, Psychosocial	KANSL1 SETBP1 PHIP	2.24e-03	139	55	3	C0025363
Disease	Profound Mental Retardation	KANSL1 SETBP1 PHIP	2.24e-03	139	55	3	C0020796
Disease	Mental deficiency	KANSL1 SETBP1 PHIP	2.24e-03	139	55	3	C0917816
Disease	dilated cardiomyopathy (is_marker_for)	CD40 TRDN	2.42e-03	39	55	2	DOID:12930 (is_marker_for)
Disease	risk-taking behaviour	KCNC2 STIMATE CD40 ARID5B REST PKD1L3	2.91e-03	764	55	6	EFO_0008579
Disease	Mammary Carcinoma, Human	SFRP5 SETBP1 LRRC37A2 CD40 L3MBTL3	2.93e-03	525	55	5	C4704874

Protein segments in the cluster

Peptide	Gene	Start	Entry
IPKKTKKHLEGKTPK	AFDN	351	P55196
PSPSAKQHKKAKKRK	C16orf86	146	Q6ZW13
AKKPGKHSDKPLKAK	BAZ1B	391	Q9UIG0
IPKDSKKKKHELKIT	AFAP1	206	Q8N556
ARRIKKKKSKPPEKK	CEP57	256	Q86XR8
VKKPSPSKARKKKLN	DOT1L	386	Q8TEK3
GPKKKKVTLHIKWPK	DHX30	81	Q7L2E3
DPKCSRKKKPKLSLK	L3MBTL3	166	Q96JM7
PQADPKSRKKKLLKK	FAM47C	86	Q5HY64
SKKPPLRKDKKEKSN	REST	811	Q13127
KQKLPRKRKKHIPPA	KCNC2	486	Q96PR1
HRTPKVKKSPKVRKK	LRRC37A3	1316	O60309
HRTPKVKKSPKVRKK	LRRC37A2	1316	A6NM11
HESIPGKAKKPKVKK	IMUP	76	Q9GZP8
HTPKAKKKSKPLNLK	KSR2	326	Q6VAB6
QSESKPPKKKKKKRR	GPATCH4	196	Q5T3I0
EKAPSKKPVKRRKKK	EXOSC9	421	Q06265
KHRSKKCKDPKPRVK	MRTFB	276	Q9ULH7
KCKDPKPRVKKLKYH	MRTFB	281	Q9ULH7
KIKPPKKLSLKHRAP	KANSL1	696	Q7Z3B3
RTPKKKKIKLSHPKD	KDM5B	1431	Q9UGL1
SKNRHKKPKDPKPKV	MYOCD	246	Q8IZQ8
KKRLKISKKPKDPEP	EXOSC10	796	Q01780
KPKKHPKVAVKAKPS	HS1BP3	211	Q53T59
RKAKEPKKAKEHKEP	CHD6	131	Q8TD26
KPHDPDSQKKLRKKS	CFAP126	116	Q5VTH2
EKLSEKKKKVKPPRT	DNAAF11	276	Q86X45
KKPRKLLPSLKTKKP	FAM118B	26	Q9BPY3
VSRKRNKKKKVPPKT	BEND7	211	Q8N7W2
KTKKKKSSRLPPEKP	MED1	686	Q15648
KEKKKKKNRHSPDHP	MED19	216	A0JLT2
PKHVKKRKEKTAKTK	RIOK1	551	Q9BRS2
RSEPLRKKKKVDPKK	MRPL40	46	Q9NQ50
SSPLRKKKKSVKKHR	SRRM3	196	A6NNA2
KKKLLKPGPLKRKDT	SFRP5	226	Q5T4F7
KSVHLQKPKPDKKKF	MYH15	571	Q9Y2K3
PPSKKHHKKKKRAKR	PTCHD4	811	Q6ZW05
TKHPERTLKKKKLFK	PKD1L3	1266	Q7Z443
FTFPKKLPPRHKKKK	SLCO5A1	366	Q9H2Y9
DSKKTKKRPPPVEKK	CCT8L1P	536	A6NM43
KVKRKPNLHALSKPK	SPICE1	296	Q8N0Z3
PISKPKRKREKKEKK	BRD2	541	P25440
TKRIKHEIPKSKKEK	ARID5B	441	Q14865
EKKPEAPKLSKKKLR	SF3B2	441	Q13435
PLEEPKAKKHKKSKK	USP42	1186	Q9H9J4
SPKKKKPKERKQKRL	PHIP	911	Q8WWQ0
HKKLKKCIKTPEIPS	SNX24	46	Q9Y343
RKASHTPKKWPKKPK	RSL1D1	471	O76021
LPEKKKKKAKGHPAT	IGHMBP2	861	P38935
PKKKKKPTLRTPVKL	GEMIN5	741	Q8TEQ6
RLTPLKPVKKKKHRF	STIMATE	276	Q86TL2
KKQKSPTKRTHRKKP	WDR53	276	Q7Z5U6
PPLRKKEIHKDKTEK	TRDN	136	Q13061
EKTAKPKPTKKAEHR	TRDN	571	Q13061
KKRKKPATCKQELPK	ZNF75D	336	P51815
RKPPSRLKKLKIKKQ	STMND1	146	H3BQB6
LSKKPKKAVKIKPHP	ZFAND4	236	Q86XD8
ESLKKPKHKRKRKSL	SETBP1	931	Q9Y6X0
TTPKKNKHKRKKVKL	RPS27A	86	P62979
KKVAKKPTNKAPHPK	CD40	216	P25942
AKQKLPKKKNKHIPR	KCNC3	551	Q14003