Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DUF1220	NBPF3 NBPF15 NBPF9 NBPF1	3.35e-09	9	44	4	SM01148
Domain	NBPF	NBPF3 NBPF15 NBPF9 NBPF1	8.73e-09	11	44	4	PS51316
Domain	DUF1220	NBPF3 NBPF15 NBPF9 NBPF1	8.73e-09	11	44	4	PF06758
Domain	NBPF_dom	NBPF3 NBPF15 NBPF9 NBPF1	8.73e-09	11	44	4	IPR010630
Domain	IQ	SCN10A MYO18A MYH10	6.23e-04	71	44	3	PF00612
Domain	Myosin_tail_1	MYO18A MYH10	8.10e-04	18	44	2	PF01576
Domain	Myosin_tail	MYO18A MYH10	8.10e-04	18	44	2	IPR002928
Domain	Myosin-like_IQ_dom	MYO18A MYH10	9.04e-04	19	44	2	IPR027401
Domain	-	MYO18A MYH10	9.04e-04	19	44	2	4.10.270.10
Domain	Synaptotagmin	DOC2A RPH3A	1.00e-03	20	44	2	IPR001565
Domain	IQ_motif_EF-hand-BS	SCN10A MYO18A MYH10	1.24e-03	90	44	3	IPR000048
Domain	IQ	SCN10A MYO18A MYH10	1.37e-03	93	44	3	PS50096
Domain	MYOSIN_MOTOR	MYO18A MYH10	3.61e-03	38	44	2	PS51456
Domain	Myosin_head	MYO18A MYH10	3.61e-03	38	44	2	PF00063
Domain	Myosin_head_motor_dom	MYO18A MYH10	3.61e-03	38	44	2	IPR001609
Domain	MYSc	MYO18A MYH10	3.61e-03	38	44	2	SM00242
Domain	RmlC-like_jellyroll	RIOX2 CENPC	6.43e-03	51	44	2	IPR014710
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF3 NBPF10 NBPF19 NBPF15 NBPF9 NBPF1	2.67e-13	21	48	6	16079250
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF15 NBPF9 NBPF1	2.94e-07	10	48	3	22973535
Pubmed	Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia.	SCN10A TRPA1	5.59e-06	3	48	2	29505031
Pubmed	MYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance.	MYH10 USP45	1.12e-05	4	48	2	36929633
Pubmed	Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling.	SCN10A TRPA1	1.12e-05	4	48	2	22850668
Pubmed	Homeostatic pruning and activity of epidermal nerves are dysregulated in barrier-impaired skin during chronic itch development.	SCN10A TRPA1	1.12e-05	4	48	2	31197234
Pubmed	Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain.	SCN10A TRPA1	1.12e-05	4	48	2	32687056
Pubmed	Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism.	DOC2A RPH3A	1.86e-05	5	48	2	21521611
Pubmed	Involvement of TRPV1 and TDAG8 in Pruriception Associated with Noxious Acidosis.	SCN10A TRPA1	1.86e-05	5	48	2	27566399
Pubmed	Ca2+ sensor proteins in spontaneous release and synaptic plasticity: Limited contribution of Doc2c, rabphilin-3a and synaptotagmin 7 in hippocampal glutamatergic neurons.	DOC2A RPH3A	2.79e-05	6	48	2	33753311
Pubmed	An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.	SCN10A TRPA1	2.79e-05	6	48	2	23711479
Pubmed	Significant determinants of mouse pain behaviour.	SCN10A TRPA1	5.19e-05	8	48	2	25101983
Pubmed	Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis.	SCN10A TRPA1	6.67e-05	9	48	2	28658621
Pubmed	USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses.	MYH10 USP45	8.33e-05	10	48	2	25538220
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	NBPF10 CRACD NBPF9 NBPF1	9.07e-05	170	48	4	23314748
Pubmed	Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation.	SCN10A TRPA1	1.02e-04	11	48	2	34338291
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	MYO18A CRACD MYH10	1.11e-04	67	48	3	29254152
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	DOC2A KPNA4 MYO18A NFE2L3 INTU MYH10 CENPC FAM186A PRRC2B	1.37e-04	1442	48	9	35575683
Pubmed	Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia.	SCN10A TRPA1	1.44e-04	13	48	2	35263589
Pubmed	Etv4 regulates nociception by controlling peptidergic sensory neuron development and peripheral tissue innervation.	SCN10A TRPA1	1.44e-04	13	48	2	35904071
Pubmed	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	DOC2A HIPK3 MYH10 ACVR1	1.48e-04	193	48	4	20677014
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CRACD INTU MYH10 DOCK9 PRRC2B	2.42e-04	407	48	5	12693553
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	SCN10A KPNA4 NBPF19 ANKRD62 NBPF9	3.12e-04	430	48	5	35044719
Pubmed	Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation.	SCN10A TRPA1	3.49e-04	20	48	2	33789102
Pubmed	ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.	SCN10A TRPA1	3.85e-04	21	48	2	25369838
Pubmed	Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain.	SCN10A TRPA1	4.63e-04	23	48	2	16446141
Pubmed	Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex.	NFE2L3 CHD8	4.63e-04	23	48	2	37071993
Pubmed	A human MAP kinase interactome.	KPNA4 MYO18A HIPK3 CHD8 MYH10	5.45e-04	486	48	5	20936779
Pubmed	Role of prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty.	NR5A1 ACVR1	6.40e-04	27	48	2	16384867
Pubmed	Stage- and subunit-specific functions of polycomb repressive complex 2 in bladder urothelial formation and regeneration.	MYH10 CYP26A1	7.39e-04	29	48	2	28049658
Pubmed	Direction selectivity in the retina is established independent of visual experience and cholinergic retinal waves.	SCN10A TRPA1	1.08e-03	35	48	2	18498732
Pubmed	Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons.	SCN10A TRPA1	1.20e-03	37	48	2	18498735
GeneFamily	Neuroblastoma breakpoint family	NBPF3 NBPF10 NBPF19 NBPF15 NBPF9 NBPF1	1.50e-12	23	31	6	662
GeneFamily	Synaptotagmin like tandem C2 proteins	DOC2A RPH3A	1.27e-04	10	31	2	822
Disease	body weights and measures, body height	ATAD5 CABLES1	2.15e-04	15	43	2	EFO_0004324, EFO_0004339
Disease	body weights and measures	ATAD5 CABLES1	1.41e-03	38	43	2	EFO_0004324
Disease	uric acid measurement	ZNF816 INTU ACVR1 RPH3A PRRC2B	1.87e-03	610	43	5	EFO_0004761
Disease	blood phosphate measurement	NBPF3 ZNF816 PARP9	2.09e-03	174	43	3	EFO_0010972
Disease	monocyte percentage of leukocytes	NFE2L3 LRRC8B LRRC31 CYP26A1 DCAF12	4.07e-03	731	43	5	EFO_0007989
Disease	cardiomyopathy (implicated_via_orthology)	DOC2A RPH3A	4.84e-03	71	43	2	DOID:0050700 (implicated_via_orthology)
Disease	interleukin 18 measurement	SCN10A NFE2L3	5.52e-03	76	43	2	EFO_0004581
Disease	forced expiratory volume	ATAD5 C3orf49 DOCK9 PRRC2B CABLES1	5.61e-03	789	43	5	EFO_0004314
Disease	Mechanical Allodynia	SCN10A TRPA1	6.70e-03	84	43	2	C2936719
Disease	Hyperalgesia	SCN10A TRPA1	6.70e-03	84	43	2	C0020429
Disease	Allodynia	SCN10A TRPA1	6.70e-03	84	43	2	C0458247
Disease	Hyperalgesia, Secondary	SCN10A TRPA1	6.70e-03	84	43	2	C0751212
Disease	Hyperalgesia, Primary	SCN10A TRPA1	6.70e-03	84	43	2	C0751211
Disease	Hyperalgesia, Thermal	SCN10A TRPA1	6.70e-03	84	43	2	C0751214
Disease	Tactile Allodynia	SCN10A TRPA1	6.70e-03	84	43	2	C0751213

Protein segments in the cluster

Peptide	Gene	Start	Entry
GNKKNNFLLCEQTKQ	TDRD1	61	Q9BXT4
NQKKLQCLNDVLGKK	ATAD5	766	Q96QE3
QRCKKNNKAELNCLG	CHD8	2366	Q9HCK8
DLKSKNILVKKNGQC	ACVR1	336	Q04771
QGKKKLCNLRFILQQ	ANKRD62	476	A6NC57
CKNKRVGKQLASQKI	DGCR8	666	Q8WYQ5
GKQICNLKCSNLKFQ	RAD51AP2	96	Q09MP3
DQKKQFEKCGLQVLK	PARP9	656	Q8IXQ6
KNAKLKNCNLRGATL	KCTD9	331	Q7L273
CRVQKGQLEKQKKFK	MTIF2	646	P46199
LAIRCVQKNIKKNKG	MYO18A	1216	Q92614
VQKCKIQKVRFQGKC	NEK5	296	Q6P3R8
GKNKVAAQNCRKRKL	NFE2L3	586	Q9Y4A8
KLGKKAVNKCLDLNN	LRRC31	81	Q6UY01
LKSQGKNCKKLAKNL	NRDE2	756	Q9H7Z3
KKNKQCQNRGILVKL	HIPK3	761	Q9H422
AEKKQQFRNLKEKCF	NBPF1	571	Q3BBV0
AAEAFKQLNQRKKGK	EPS8L2	276	Q9H6S3
LFQCKKLQCLLLGKN	LRRC8B	721	Q6P9F7
KRLLPKRCNKKNSND	INTU	121	Q9ULD6
ENKQQFRNLKQKCLV	NBPF3	86	Q9H094
QCRRFQQLKKKNGSF	C3orf49	21	Q96BT1
GACKANKLKTKTQRN	DOC2A	136	Q14183
KVLKNAKQACQRLGQ	DOCK9	506	Q9BZ29
KGKLNKQNRKLCAGA	CABLES1	551	Q8TDN4
NIGKVNKKSNKKRIC	CENPC	786	Q03188
DNCKVRALAFNNKNK	DCAF12	251	Q5T6F0
LRFNCDQQAEQKKKK	CRACD	856	Q6ZU35
KLGKCIIINNKNFDK	CASP7	66	P55210
KSKGLLCKSNQDNKL	CYP26A1	331	O43174
KQKSLGQKRNQCLKK	FAM186A	2211	A6NE01
KRFKANLEKNKQGLE	MYH10	1216	P35580
KQQKKAQIRANGFKL	NR5A1	106	Q13285
LKKLKPNQRKNFNIC	RPH3A	501	Q9Y2J0
EKKQQFRNLKEKCFL	NBPF9	301	P0DPF3
EKKQQFRNLKEKCFL	NBPF10	301	Q6P3W6
KKQQFRNLKEKCFLT	NBPF15	31	Q8N660
KKQQFRNLKEKCFLT	NBPF19	31	A0A087WUL8
RKKRKKNKCSGHNNS	CIR1	291	Q86X95
KFVGQQLKCNACRKL	ZIM3	161	Q96PE6
GLQNFNKQKKLKRCD	TRPA1	46	O75762
NNKLLCENCTKNKQK	USP45	636	Q70EL2
QLFKGNLKNKCVKND	SCN10A	266	Q9Y5Y9
AAKLKQLDQKCKQAR	PRRC2B	526	Q5JSZ5
NVCRCVNGKKKVLNK	RIOX2	101	Q8IUF8
KCNKCAKVFNQKGIL	ZNF816	566	Q0VGE8
DFGIKQAKSKRKLQN	WDR64	246	B1ANS9
KLDNQRLKNFKNKGR	KPNA4	6	O00629