Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

NFYA NFYC SOX5 CCAR1 BPTF SP1 SP2 GTF2A1 SP4 FOXP4 RFX2 CTCF

3.79e-0614593512GO:0000977
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

NFYA NFYC SOX5 CCAR1 BPTF SP1 SP2 SP4 FOXP4 RFX2 CTCF

5.46e-0612443511GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

NFYA NFYC SOX5 CCAR1 BPTF SP1 SP2 SP4 FOXP4 RFX2 CTCF

6.70e-0612713511GO:0000987
GeneOntologyMolecularFunctiontranscription factor binding

NFYA BPTF SP1 GTF2A1 NCOA6 TAF4 TAF4B CTCF

3.75e-05753358GO:0008134
GeneOntologyMolecularFunctionRNA polymerase II general transcription initiation factor activity

GTF2A1 TAF4 TAF4B

1.03e-0452353GO:0016251
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

NFYA NFYC SOX5 SP1 SP2 SP4 FOXP4 RFX2 CTCF YLPM1

1.08e-0414123510GO:0000981
GeneOntologyMolecularFunctiongeneral transcription initiation factor activity

GTF2A1 TAF4 TAF4B

2.29e-0468353GO:0140223
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

SP1 GTF2A1 NCOA6 TAF4 TAF4B CTCF

4.72e-04582356GO:0140297
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

SP1 GTF2A1 NCOA6 TAF4 TAF4B

7.51e-04417355GO:0061629
GeneOntologyMolecularFunctiontranscription coregulator binding

NFYA SP1 CTCF

1.87e-03140353GO:0001221
GeneOntologyMolecularFunctionmolecular adaptor activity

CCAR1 SUPT20HL1 SP1 NCOA6 SUPT20HL2 GTF2A1L CTCF SYNE1

2.00e-031356358GO:0060090
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

SP2 FOXP4 CTCF YLPM1

2.29e-03320354GO:0001227
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

SP2 FOXP4 CTCF YLPM1

2.45e-03326354GO:0001217
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

NFYA NFYC SP1 RFX2 CTCF

2.76e-03560355GO:0001228
GeneOntologyMolecularFunctiontranscription coregulator activity

CCAR1 SUPT20HL1 NCOA6 SUPT20HL2 GTF2A1L

2.80e-03562355GO:0003712
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

NFYA NFYC SP1 RFX2 CTCF

2.89e-03566355GO:0001216
GeneOntologyMolecularFunctionATP-dependent activity

BPTF TOMM20 CHD8 LONP2 MYO1F

4.09e-03614355GO:0140657
GeneOntologyMolecularFunctioncore promoter sequence-specific DNA binding

GTF2A1 TAF4

4.18e-0355352GO:0001046
GeneOntologyMolecularFunctionprotein heterodimerization activity

NFYC GTF2A1 TAF4 TAF4B

5.00e-03398354GO:0046982
GeneOntologyMolecularFunctionnuclear receptor coactivator activity

CCAR1 NCOA6

5.12e-0361352GO:0030374
GeneOntologyMolecularFunctionmodification-dependent protein binding

BPTF CHD8 RAD23A

5.55e-03206353GO:0140030
GeneOntologyMolecularFunctionbasal RNA polymerase II transcription machinery binding

GTF2A1 SCAF8

5.97e-0366352GO:0001099
GeneOntologyMolecularFunctionbasal transcription machinery binding

GTF2A1 SCAF8

5.97e-0366352GO:0001098
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

CCAR1 RNF216 MAGEL2 NEURL4

9.11e-03473354GO:0004842
GeneOntologyMolecularFunctionmethylated histone binding

BPTF CHD8

9.95e-0386352GO:0035064
GeneOntologyMolecularFunctionmethylation-dependent protein binding

BPTF CHD8

1.04e-0288352GO:0140034
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

CCAR1 RNF216 MAGEL2 NEURL4

1.19e-02512354GO:0019787
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

NFYA NFYC SUPT20HL1 BPTF SP1 GTF2A1 NCOA6 CHD8 SUPT20HL2 TAF4 TAF4B MBTPS2 RFX2 CTCF

2.26e-0813903514GO:0045944
GeneOntologyBiologicalProcessDNA-templated transcription initiation

GTF2A1 NCOA6 TAF4 TAF4B GTF2A1L

4.16e-05231355GO:0006352
GeneOntologyBiologicalProcessin utero embryonic development

SOX5 BPTF SP1 SP2 NCOA6 CHD8 CTCF

5.40e-05596357GO:0001701
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

SOX5 CCAR1 BPTF SP2 CHD8 FOXP4 MAGEL2 CTCF SCAF8 YLPM1

7.64e-0513993510GO:0045892
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

SOX5 CCAR1 BPTF SP2 CHD8 FOXP4 MAGEL2 CTCF SCAF8 YLPM1

8.31e-0514133510GO:1902679
GeneOntologyBiologicalProcessmRNA transcription by RNA polymerase II

SP1 TAF4 TAF4B

9.34e-0552353GO:0042789
GeneOntologyBiologicalProcessembryo development

SOX5 SUPT20HL1 BPTF SP1 SP2 NCOA6 CHD8 FOXP4 SUPT20HL2 CTCF

9.57e-0514373510GO:0009790
GeneOntologyBiologicalProcessmRNA transcription

SP1 TAF4 TAF4B

1.23e-0457353GO:0009299
GeneOntologyBiologicalProcesspositive regulation of transcription initiation by RNA polymerase II

GTF2A1 TAF4 TAF4B

2.27e-0470353GO:0060261
GeneOntologyBiologicalProcessRNA polymerase II preinitiation complex assembly

GTF2A1 TAF4 TAF4B

2.36e-0471353GO:0051123
GeneOntologyBiologicalProcesstranscription initiation at RNA polymerase II promoter

GTF2A1 TAF4 TAF4B GTF2A1L

2.69e-04186354GO:0006367
GeneOntologyBiologicalProcesspositive regulation of DNA-templated transcription initiation

GTF2A1 TAF4 TAF4B

3.00e-0477353GO:2000144
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

BPTF SP2 CHD8 FOXP4 MAGEL2 CTCF SCAF8 YLPM1

3.08e-041053358GO:0000122
GeneOntologyBiologicalProcessregulation of transcription initiation by RNA polymerase II

GTF2A1 TAF4 TAF4B

3.49e-0481353GO:0060260
GeneOntologyBiologicalProcesstranscription preinitiation complex assembly

GTF2A1 TAF4 TAF4B

4.02e-0485353GO:0070897
GeneOntologyBiologicalProcessregulation of DNA-templated transcription initiation

GTF2A1 TAF4 TAF4B

4.91e-0491353GO:2000142
GeneOntologyBiologicalProcesschordate embryonic development

SOX5 BPTF SP1 SP2 NCOA6 CHD8 CTCF

7.05e-04906357GO:0043009
GeneOntologyBiologicalProcessembryo development ending in birth or egg hatching

SOX5 BPTF SP1 SP2 NCOA6 CHD8 CTCF

8.17e-04929357GO:0009792
GeneOntologyBiologicalProcessDNA damage response

SUPT20HL1 NCOA6 SUPT20HL2 TAF4 MBTPS2 NEURL4 RAD23A

9.85e-04959357GO:0006974
GeneOntologyBiologicalProcessembryonic placenta development

BPTF SP1 NCOA6

1.07e-03119353GO:0001892
GeneOntologyCellularComponentchromatin

NFYA NFYC SOX5 SUPT20HL1 BPTF SP1 SP2 SP4 CHD8 FOXP4 SUPT20HL2 TOX4 TAF4 RFX2

4.22e-0814803514GO:0000785
GeneOntologyCellularComponenttranscription regulator complex

NFYA NFYC SOX5 SP1 GTF2A1 NCOA6 TAF4 TAF4B GTF2A1L

4.27e-07596359GO:0005667
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

NFYA NFYC GTF2A1 TAF4 TAF4B GTF2A1L

5.43e-06272356GO:0090575
GeneOntologyCellularComponentnuclear protein-containing complex

NFYA NFYC BPTF GTF2A1 NCOA6 CHD8 TAF4 TAF4B GTF2A1L SCAF8 SYNE1

9.31e-0613773511GO:0140513
GeneOntologyCellularComponentRNA polymerase II, holoenzyme

GTF2A1 TAF4 TAF4B GTF2A1L

1.45e-0589354GO:0016591
GeneOntologyCellularComponenttranscription factor TFIIA complex

GTF2A1 GTF2A1L

2.71e-055352GO:0005672
GeneOntologyCellularComponentnuclear DNA-directed RNA polymerase complex

GTF2A1 TAF4 TAF4B GTF2A1L

3.72e-05113354GO:0055029
GeneOntologyCellularComponentSAGA-type complex

SUPT20HL1 SUPT20HL2 TAF4

3.77e-0539353GO:0070461
GeneOntologyCellularComponentCCAAT-binding factor complex

NFYA NFYC

4.07e-056352GO:0016602
GeneOntologyCellularComponentDNA-directed RNA polymerase complex

GTF2A1 TAF4 TAF4B GTF2A1L

4.13e-05116354GO:0000428
GeneOntologyCellularComponentRNA polymerase complex

GTF2A1 TAF4 TAF4B GTF2A1L

4.56e-05119354GO:0030880
GeneOntologyCellularComponenttranscription factor TFIID complex

GTF2A1 TAF4 TAF4B

6.63e-0547353GO:0005669
GeneOntologyCellularComponenttransferase complex

SUPT20HL1 GTF2A1 NCOA6 CHD8 SUPT20HL2 TAF4 TAF4B GTF2A1L

1.53e-04963358GO:1990234
GeneOntologyCellularComponenthistone methyltransferase complex

NCOA6 CHD8 TAF4

2.67e-0475353GO:0035097
GeneOntologyCellularComponentmale germ cell nucleus

TAF4 GTF2A1L CTCF

4.00e-0486353GO:0001673
GeneOntologyCellularComponenthistone acetyltransferase complex

SUPT20HL1 SUPT20HL2 TAF4

5.19e-0494353GO:0000123
GeneOntologyCellularComponentprotein acetyltransferase complex

SUPT20HL1 SUPT20HL2 TAF4

6.97e-04104353GO:0031248
GeneOntologyCellularComponentmethyltransferase complex

NCOA6 CHD8 TAF4

7.78e-04108353GO:0034708
GeneOntologyCellularComponentSAGA complex

SUPT20HL1 SUPT20HL2

7.97e-0425352GO:0000124
GeneOntologyCellularComponentacetyltransferase complex

SUPT20HL1 SUPT20HL2 TAF4

7.99e-04109353GO:1902493
GeneOntologyCellularComponentgerm cell nucleus

TAF4 GTF2A1L CTCF

8.87e-04113353GO:0043073
GeneOntologyCellularComponentintracellular protein-containing complex

SUPT20HL1 GTF2A1 SUPT20HL2 TAF4 TAF4B GTF2A1L RAD23A

9.86e-04972357GO:0140535
GeneOntologyCellularComponentMLL1 complex

CHD8 TAF4

1.31e-0332352GO:0071339
GeneOntologyCellularComponentMLL1/2 complex

CHD8 TAF4

1.39e-0333352GO:0044665
GeneOntologyCellularComponentpeptidase complex

SUPT20HL1 SUPT20HL2 RAD23A

1.42e-03133353GO:1905368
GeneOntologyCellularComponenttransferase complex, transferring phosphorus-containing groups

GTF2A1 TAF4 TAF4B GTF2A1L

2.29e-03335354GO:0061695
HumanPhenoMotor delay

SOX5 BPTF CHD8 QRICH1 MAGEL2 TAF4 MBTPS2 CTCF SYNE1

6.03e-051018129HP:0001270
HumanPhenoClinodactyly

SOX5 BPTF RNF216 QRICH1 MAGEL2 TAF4 CTCF

1.06e-04574127HP:0030084
HumanPhenoPica

CHD8 TAF4

1.41e-048122HP:0011856
HumanPhenoOpen mouth

SOX5 CHD8 MAGEL2 CTCF

1.42e-04124124HP:0000194
HumanPhenoAbnormal internal genitalia

SOX5 BPTF RNF216 EYS MAGEL2 TAF4 TAF4B MBTPS2 CTCF SYNE1

1.68e-0414981210HP:0000812
HumanPhenoFeeding difficulties

SOX5 BPTF CHD8 QRICH1 MAGEL2 TAF4 MBTPS2 CTCF SYNE1

1.89e-041168129HP:0011968
HumanPhenoPremature adrenarche

MAGEL2 TAF4

2.27e-0410122HP:0012412
HumanPhenoMacrotia

QRICH1 TAF4 MBTPS2 CTCF SYNE1

2.39e-04271125HP:0000400
HumanPhenoRadial deviation of finger

BPTF RNF216 QRICH1 MAGEL2 TAF4 CTCF

2.61e-04448126HP:0009466
HumanPhenoRadial deviation of the hand or of fingers of the hand

BPTF RNF216 QRICH1 MAGEL2 TAF4 CTCF

2.88e-04456126HP:0009485
HumanPhenoAbnormality of upper lip vermillion

BPTF CHD8 QRICH1 MAGEL2 TAF4 CTCF

3.17e-04464126HP:0011339
HumanPhenoThick eyebrow

BPTF MAGEL2 TAF4 CTCF

3.29e-04154124HP:0000574
HumanPhenoAbnormality of refraction

SOX5 BPTF MAGEL2 TAF4 MBTPS2 CTCF SYNE1

4.12e-04709127HP:0000539
HumanPhenoAbnormal pinna morphology

SOX5 BPTF CHD8 QRICH1 MAGEL2 TAF4 MBTPS2 CTCF SYNE1

4.53e-041299129HP:0000377
HumanPhenoAbnormality of the philtrum

BPTF CHD8 QRICH1 MAGEL2 TAF4 CTCF SYNE1

4.78e-04726127HP:0000288
HumanPhenoAbnormal 5th finger morphology

BPTF RNF216 QRICH1 TAF4 MBTPS2 CTCF

5.28e-04509126HP:0004207
HumanPhenoKyphosis

SOX5 MAGEL2 TAF4 MBTPS2 CTCF SYNE1

5.33e-04510126HP:0002808
HumanPhenoSlanting of the palpebral fissure

SOX5 BPTF CHD8 QRICH1 MAGEL2 TAF4 CTCF

5.35e-04739127HP:0200006
HumanPhenoAggressive behavior

SOX5 BPTF CHD8 MAGEL2 TAF4 CTCF

5.69e-04516126HP:0000718
HumanPhenoAbnormal aggressive, impulsive or violent behavior

SOX5 BPTF CHD8 MAGEL2 TAF4 CTCF

5.69e-04516126HP:0006919
HumanPhenoAbnormality of the outer ear

SOX5 BPTF CHD8 QRICH1 MAGEL2 TAF4 MBTPS2 CTCF SYNE1

5.72e-041337129HP:0000356
HumanPhenoUpslanted palpebral fissure

BPTF QRICH1 MAGEL2 TAF4 CTCF

6.26e-04333125HP:0000582
HumanPhenoDeviation of finger

BPTF RNF216 QRICH1 MAGEL2 TAF4 CTCF

7.07e-04537126HP:0004097
HumanPhenoAbnormal finger morphology

SOX5 BPTF RNF216 QRICH1 MAGEL2 TAF4 MBTPS2 CTCF SYNE1

7.61e-041385129HP:0001167
MousePhenoabnormal primitive streak morphology

SUPT20HL1 BPTF CHD8 SUPT20HL2 YLPM1

7.33e-05201315MP:0002231
MousePhenoabnormal left-right axis symmetry of the somites

SUPT20HL1 SUPT20HL2

1.32e-048312MP:0005224
MousePhenoabnormal mesoderm morphology

SUPT20HL1 BPTF CHD8 SUPT20HL2

1.69e-04127314MP:0014141
MousePhenoabnormal gastrulation movements

SUPT20HL1 SUPT20HL2

2.12e-0410312MP:0002174
MousePhenoabnormal germ layer development

SUPT20HL1 BPTF CHD8 SUPT20HL2

2.74e-04144314MP:0001674
MousePhenoabnormal fibroblast apoptosis

NFYA NCOA6 TAF4

3.42e-0462313MP:0013500
MousePhenoabnormal head fold morphology

SUPT20HL1 SUPT20HL2 YLPM1

3.75e-0464313MP:0011257
MousePhenoabnormal germ layer morphology

SUPT20HL1 BPTF CHD8 SUPT20HL2

4.19e-04161314MP:0014138
MousePhenoabnormal gastrulation

SUPT20HL1 BPTF SP2 CHD8 SUPT20HL2 YLPM1

4.98e-04469316MP:0001695
MousePhenoembryonic lethality during organogenesis

BPTF SP1 SP2 NCOA6 CHD8 FOXP4 TAF4 CTCF

4.98e-04876318MP:0006207
MousePhenoabnormal embryo development

SUPT20HL1 BPTF SP2 TOMM20 NCOA6 CHD8 SUPT20HL2 TOX4 CTCF YLPM1

5.11e-0413703110MP:0001672
MousePhenoabnormal fibroblast proliferation

NFYA SP2 NCOA6 TAF4

5.73e-04175314MP:0011702
MousePhenoabnormal sexual maturation

SP4 MAGEL2 TAF4B

5.75e-0474313MP:0001937
MousePhenoembryonic lethality during organogenesis, complete penetrance

BPTF SP1 SP2 NCOA6 CHD8 TAF4 CTCF

7.02e-04700317MP:0011098
DomainSp1_fam

SP1 SP2 SP4

6.56e-0710343IPR030450
DomainTFIIA_asu/bsu

GTF2A1 GTF2A1L

3.22e-062342IPR004855
DomainTFIIA

GTF2A1 GTF2A1L

3.22e-062342SM01371
DomainTFIIA_asu_N

GTF2A1 GTF2A1L

3.22e-062342IPR013028
DomainTAF4

TAF4 TAF4B

3.22e-062342PF05236
DomainTFIIA

GTF2A1 GTF2A1L

3.22e-062342PF03153
Domain-

GTF2A1 GTF2A1L

3.22e-0623421.10.287.100
DomainTAF4

TAF4 TAF4B

3.22e-062342IPR007900
Domain-

GTF2A1 GTF2A1L

9.64e-0633422.30.18.10
DomainTFIIA_b-brl

GTF2A1 GTF2A1L

9.64e-063342IPR009088
DomainTFIIA_a-hlx

GTF2A1 GTF2A1L

1.93e-054342IPR009083
DomainTAFH

TAF4 TAF4B

3.21e-055342PS51119
DomainTAFH

TAF4 TAF4B

3.21e-055342SM00549
DomainTAFH

TAF4 TAF4B

3.21e-055342PF07531
DomainTAFH_NHR1

TAF4 TAF4B

3.21e-055342IPR003894
Domain-

NFYC TAF4 TAF4B

2.66e-04693431.10.20.10
DomainHistone-fold

NFYC TAF4 TAF4B

4.58e-0483343IPR009072
DomainHMG_box

SOX5 TOX4

4.18e-0353342PF00505
DomainHMG_BOX_2

SOX5 TOX4

4.34e-0354342PS50118
DomainHMG

SOX5 TOX4

4.34e-0354342SM00398
Domain-

SOX5 TOX4

4.50e-03553421.10.30.10
DomainHMG_box_dom

SOX5 TOX4

6.23e-0365342IPR009071
DomainZINC_FINGER_C2H2_2

SP1 SP2 SP4 FOXP4 CTCF

1.24e-02775345PS50157
DomainZINC_FINGER_C2H2_1

SP1 SP2 SP4 FOXP4 CTCF

1.26e-02777345PS00028
PathwayREACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF

NFYA NFYC SP1 NCOA6 MBTPS2

3.01e-0855245M27001
PathwayBIOCARTA_TERC_PATHWAY

NFYA NFYC SP1

8.64e-086243MM1564
PathwayBIOCARTA_TERC_PATHWAY

NFYA NFYC SP1

8.64e-086243M22047
PathwayKEGG_BASAL_TRANSCRIPTION_FACTORS

GTF2A1 TAF4 TAF4B GTF2A1L

3.27e-0735244M4864
PathwayREACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP

NFYA NFYC SP1 NCOA6

6.93e-0742244M27172
PathwayREACTOME_ATF6_ATF6_ALPHA_ACTIVATES_CHAPERONES

NFYA NFYC MBTPS2

9.44e-0712243M794
PathwayREACTOME_METABOLISM_OF_STEROIDS

NFYA NFYC SP1 NCOA6 MBTPS2

5.24e-06154245M27832
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

NFYA NFYC SP1 NCOA6

4.36e-05118244M27316
PathwayREACTOME_HIV_TRANSCRIPTION_INITIATION

GTF2A1 TAF4 TAF4B

6.69e-0547243M29568
PathwayREACTOME_RNA_POLYMERASE_II_PROMOTER_ESCAPE

GTF2A1 TAF4 TAF4B

7.13e-0548243MM15424
PathwayREACTOME_ATF6_ATF6_ALPHA_ACTIVATES_CHAPERONE_GENES

NFYA NFYC

1.24e-0410242M801
PathwayWP_SIDS_SUSCEPTIBILITY_PATHWAYS

NFYA SP1 CTCF

1.32e-0459243MM15838
PathwayPID_MYC_REPRESS_PATHWAY

NFYA NFYC SP1

1.61e-0463243M254
PathwayREACTOME_TRANSCRIPTION_OF_THE_HIV_GENOME

GTF2A1 TAF4 TAF4B

2.20e-0470243M27008
PathwayWP_STEROL_REGULATORY_ELEMENTBINDING_PROTEINS_SREBP_SIGNALING

NFYA SP1 MBTPS2

2.30e-0471243M39395
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES

NFYA NFYC

3.29e-0416242M27940
PathwayREACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS

GTF2A1 TAF4 TAF4B

3.39e-0481243M865
PathwayREACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS

GTF2A1 TAF4 TAF4B

3.64e-0483243MM15314
PathwayREACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR

NFYA NFYC MBTPS2

5.09e-0493243M10294
PathwayREACTOME_ATF4_ACTIVATES_GENES_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS

NFYA NFYC

9.50e-0427242M796
PathwayWP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY

SP1 NCOA6

1.25e-0331242M39476
PathwayREACTOME_PERK_REGULATES_GENE_EXPRESSION

NFYA NFYC

1.34e-0332242M792
PathwayPID_P53_DOWNSTREAM_PATHWAY

NFYA NFYC SP1

1.57e-03137243M145
PathwayWP_ENDODERM_DIFFERENTIATION

BPTF SP4 TAF4B

1.77e-03143243M39591
PathwayREACTOME_HIV_LIFE_CYCLE

GTF2A1 TAF4 TAF4B

1.99e-03149243M4076
PathwayWP_SUDDEN_INFANT_DEATH_SYNDROME_SIDS_SUSCEPTIBILITY_PATHWAYS

NFYA SP1 CTCF

2.39e-03159243M39373
PathwayWP_MECP2_AND_ASSOCIATED_RETT_SYNDROME

SP1 CTCF

2.75e-0346242MM15949
PathwayKEGG_HUNTINGTONS_DISEASE

SP1 TAF4 TAF4B

3.51e-03182243M13486
PathwayREACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION

SP1 GTF2A1

5.09e-0363242MM15613
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

NFYA NFYC SOX5 CCAR1 BPTF SP1 SP2 GTF2A1 SP4 TOX4 RFX2 CTCF

1.71e-11808361220412781
Pubmed

Human transcription factor protein interaction networks.

NFYA NFYC SOX5 CCAR1 BPTF SP1 SP2 NCOA6 CHD8 FOXP4 TAF4 CTCF SCAF8 YLPM1

5.96e-111429361435140242
Pubmed

Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.

SP1 SP2 SP4

4.07e-09436327889927
Pubmed

Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases.

SP1 SP2 SP4

4.07e-09436315788387
Pubmed

Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter.

SP1 SP2 SP4

1.02e-08536310547281
Pubmed

A census of human transcription factors: function, expression and evolution.

NFYA NFYC SOX5 SP1 SP2 SP4 FOXP4 TOX4 RFX2 CTCF

1.92e-08908361019274049
Pubmed

Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system.

SP1 SP2 SP4

2.03e-08636314576192
Pubmed

Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells.

SP1 SP2 SP4

2.03e-08636316201967
Pubmed

Core promoter binding by histone-like TAF complexes.

GTF2A1 TAF4 TAF4B

5.68e-08836315601843
Pubmed

Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.

SP1 GTF2A1 TAF4 TAF4B

1.53e-07463648849451
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

SP1 CHD8 QRICH1 TOX4 CTCF LONP2 YLPM1

1.87e-0741036726949251
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

BPTF GTF2A1 NCOA6 CHD8 TOX4 YLPM1

4.37e-0728336630585729
Pubmed

A human MAP kinase interactome.

NFYA NFYC SP1 GTF2A1 CHD8 TOX4 SYNE1

5.86e-0748636720936779
Pubmed

Architecture of TAF11/TAF13/TBP complex suggests novel regulation properties of general transcription factor TFIID.

GTF2A1 TAF4 TAF4B

8.22e-071836329111974
Pubmed

Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex.

GTF2A1 TAF4 TAF4B

9.76e-07193638764062
Pubmed

CTCF and Sp1 interact with the Murine gammaherpesvirus 68 internal repeat elements.

SP1 CTCF

1.04e-06236222706977
Pubmed

O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y.

NFYA SP1

1.04e-06236219302979
Pubmed

CTCF-dependent chromatin insulator is linked to epigenetic remodeling.

CHD8 CTCF

1.04e-06236216949368
Pubmed

Increased SP4 and SP1 transcription factor expression in the postmortem hippocampus of chronic schizophrenia.

SP1 SP4

1.04e-06236225175639
Pubmed

Structural changes in TAF4b-TFIID correlate with promoter selectivity.

TAF4 TAF4B

1.04e-06236218206971
Pubmed

Identification of heteromolecular binding sites in transcription factors Sp1 and TAF4 using high-resolution nuclear magnetic resonance spectroscopy.

SP1 TAF4

1.04e-06236228857320
Pubmed

Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators.

SP1 TAF4

1.04e-0623629742090
Pubmed

Interaction between intrinsically disordered regions in transcription factors Sp1 and TAF4.

SP1 TAF4

1.04e-06236227515574
Pubmed

Reduced expression of SP1 and SP4 transcription factors in peripheral blood mononuclear cells in first-episode psychosis.

SP1 SP4

1.04e-06236223941741
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

BPTF NCOA6 CHD8 TOX4 TAF4 AMOTL2 YLPM1

1.32e-0654936738280479
Pubmed

Interaction network of human early embryonic transcription factors.

SOX5 BPTF NCOA6 CHD8 FOXP4 TAF4

1.53e-0635136638297188
Pubmed

Mammalian SP/KLF transcription factors: bring in the family.

SP1 SP2 SP4

2.31e-062536315820306
Pubmed

An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.

NFYC SP1 AMOTL2 RFX2

2.42e-069136420362542
Pubmed

Functional interactions between NURF and Ctcf regulate gene expression.

BPTF CTCF

3.12e-06336225348714
Pubmed

Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions.

NFYA SP1

3.12e-06336210446910
Pubmed

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.

SP1 TAF4

3.12e-06336211988536
Pubmed

A transcription factor IIA-binding site differentially regulates RNA polymerase II-mediated transcription in a promoter context-dependent manner.

GTF2A1 TAF4

3.12e-06336228539359
Pubmed

Epigenetic role of CCAAT box-binding transcription factor NF-Y on ID gene family in human embryonic carcinoma cells.

NFYA NFYC

3.12e-06336226509926
Pubmed

Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox.

NFYA NFYC

3.12e-0633628910521
Pubmed

TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3.

TAF4 TAF4B

3.12e-06336224498316
Pubmed

Analysis of Sp transcription factors in the postmortem brain of chronic schizophrenia: a pilot study of relationship to negative symptoms.

SP1 SP4

3.12e-06336223540600
Pubmed

Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes.

NFYA SP1

3.12e-06336218654640
Pubmed

Nuclear factor Y (NF-Y) and cellular senescence.

NFYA NFYC

3.12e-06336210585259
Pubmed

Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1.

NFYA SP1

3.12e-06336210393239
Pubmed

Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells.

SP1 SP4

3.12e-06336226967243
Pubmed

Curcumin decreases specificity protein expression in bladder cancer cells.

SP1 SP4

3.12e-06336218593936
Pubmed

Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.

SP1 SP4

3.12e-06336221919647
Pubmed

O-GlcNAc modification of Sp3 and Sp4 transcription factors negatively regulates their transcriptional activities.

SP2 SP4

3.12e-06336226431879
Pubmed

The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5.

SUPT20HL1 SUPT20HL2

3.12e-06336224220028
Pubmed

Synergistic regulation of human cystathionine-beta-synthase-1b promoter by transcription factors NF-YA isoforms and Sp1.

NFYA SP1

3.12e-06336212427542
Pubmed

Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins.

SP1 SP4

3.12e-06336215345676
Pubmed

Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination.

NFYA NFYC

3.12e-06336223332751
Pubmed

Frequent disruption of chromodomain helicase DNA-binding protein 8 (CHD8) and functionally associated chromatin regulators in prostate cancer.

CHD8 CTCF

3.12e-06336225499215
Pubmed

Zinc finger independent genome-wide binding of Sp2 potentiates recruitment of histone-fold protein Nf-y distinguishing it from Sp1 and Sp3.

SP1 SP2

3.12e-06336225793500
Pubmed

Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene.

SP1 SP4

3.12e-06336211532028
Pubmed

Histone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors.

NFYA NFYC

3.12e-06336225132174
Pubmed

The molecular biology of the CCAAT-binding factor NF-Y.

NFYA NFYC

3.12e-06336210571030
Pubmed

Gene expression of the tumour suppressor LKB1 is mediated by Sp1, NF-Y and FOXO transcription factors.

NFYC SP1

3.12e-06336222412893
Pubmed

Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3.

SP1 SP4

3.12e-0633627559627
Pubmed

The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.

SUPT20HL1 SUPT20HL2 TAF4

3.28e-062836319114550
Pubmed

A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.

SUPT20HL1 SUPT20HL2 TAF4

4.06e-063036318206972
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

CCAR1 BPTF NCOA6 CHD8 TOX4 TAF4 CTCF YLPM1

4.76e-0695436836373674
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

SP1 NCOA6 SP4 MAGEL2 NEURL4 YLPM1

4.91e-0643036635044719
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

CCAR1 BPTF SP1 SP2 NCOA6 TOX4 TAF4 CTCF YLPM1

5.04e-06129436930804502
Pubmed

Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.

SUPT20HL1 SUPT20HL2 TAF4

5.44e-063336311564863
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

CCAR1 BPTF CHD8 TOX4 CTCF

5.91e-0625136531076518
Pubmed

Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx.

SP1 SP4

6.24e-06436215781457
Pubmed

Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response.

NFYA NFYC

6.24e-06436211158310
Pubmed

NF-Y binding is required for transactivation of neuronal aromatic L-amino acid decarboxylase gene promoter by the POU-domain protein Brn-2.

NFYA NFYC

6.24e-06436211311976
Pubmed

NF-Y recruits Ash2L to impart H3K4 trimethylation on CCAAT promoters.

NFYA NFYC

6.24e-06436221445285
Pubmed

Transcription factor NF-Y is a functional regulator of the transcription of core clock gene Bmal1.

NFYA SP1

6.24e-06436224030830
Pubmed

SP1-mediated upregulation of lncRNA ILF3-AS1 functions a ceRNA for miR-212 to contribute to osteosarcoma progression via modulation of SOX5.

SOX5 SP1

6.24e-06436230819403
Pubmed

TAF4/4b x TAF12 displays a unique mode of DNA binding and is required for core promoter function of a subset of genes.

TAF4 TAF4B

6.24e-06436219635797
Pubmed

A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation.

SP1 YLPM1

6.24e-06436215511642
Pubmed

Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y).

NFYA NFYC

6.24e-0643629388234
Pubmed

Transcriptional modulation of the pre-implantation embryo-specific Rnf35 gene by the Y-box protein NF-Y/CBF.

NFYA NFYC

6.24e-06436215516209
Pubmed

Curcumin ameliorates PRMT5-MEP50 arginine methyltransferase expression by decreasing the Sp1 and NF-YA transcription factors in the A549 and MCF-7 cells.

NFYA SP1

6.24e-06436230392062
Pubmed

NF-Y affects histone acetylation and H2A.Z deposition in cell cycle promoters.

NFYA NFYC

6.24e-06436221304275
Pubmed

Transcriptional regulation of the Alström syndrome gene ALMS1 by members of the RFX family and Sp1.

SP1 RFX2

6.24e-06436220381594
Pubmed

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.

BPTF NCOA6 TOX4 RAD23A

7.05e-0611936423508102
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

SOX5 SP1 SP2 GTF2A1 FOXP4 QRICH1 TOX4

7.09e-0670936722988430
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

CCAR1 BPTF CHD8 QRICH1 TAF4 CTCF YLPM1 RAD23A

7.44e-06101436832416067
Pubmed

The general transcription factors of RNA polymerase II.

GTF2A1 TAF4 TAF4B

9.07e-06393638946909
Pubmed

Three transitions in the RNA polymerase II transcription complex during initiation.

GTF2A1 TAF4 TAF4B

9.07e-06393639405375
Pubmed

Abortive initiation is increased only for the weakest members of a set of down mutants of the adenovirus 2 major late promoter.

GTF2A1 TAF4 TAF4B

9.80e-06403631939271
Pubmed

ATP activates transcription initiation from promoters by RNA polymerase II in a reversible step prior to RNA synthesis.

GTF2A1 TAF4 TAF4B

9.80e-06403632449431
Pubmed

Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function.

NFYA NFYC

1.04e-05536212482752
Pubmed

Bone morphogenetic protein 2 mediates dentin sialophosphoprotein expression and odontoblast differentiation via NF-Y signaling.

NFYA NFYC

1.04e-05536218424784
Pubmed

TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general transcription factors during spermatogenesis in the mouse.

GTF2A1 GTF2A1L

1.04e-05536211159353
Pubmed

Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.

NFYA NFYC

1.04e-05536215831478
Pubmed

Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors.

SP1 SP4

1.04e-05536212560508
Pubmed

Developmental and cell type-specific regulation of core promoter transcription factors in germ cells of frogs and mice.

GTF2A1 GTF2A1L

1.04e-05536216412700
Pubmed

Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.

SP1 SP4

1.04e-05536220538607
Pubmed

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response.

NFYA NFYC

1.04e-05536211256944
Pubmed

Transcriptional regulation of N-acetylglutamate synthase.

NFYA SP1

1.04e-05536222383952
Pubmed

Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis.

GTF2A1 GTF2A1L

1.04e-05536210364255
Pubmed

NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.

BPTF CHD8

1.04e-05536226626481
Pubmed

ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1.

SP1 TAF4

1.04e-05536212771217
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

CCAR1 BPTF NCOA6 SP4 CHD8 QRICH1 TAF4 RAD23A

1.37e-05110336834189442
Pubmed

p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y.

NFYA NFYC

1.56e-05636214586402
Pubmed

Differential intranuclear organization of transcription factors Sp1 and Sp3.

SP1 SP2

1.56e-05636215987735
Pubmed

Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway.

NFYA NFYC

1.56e-05636212857729
Pubmed

Positive and negative TAF(II) functions that suggest a dynamic TFIID structure and elicit synergy with traps in activator-induced transcription.

GTF2A1 TAF4

1.56e-05636211564872
Pubmed

The transcription factor Sp1 modulates RNA polymerase III gene transcription by controlling BRF1 and GTF3C2 expression in human cells.

SP1 GTF2A1

1.56e-05636232115405
Pubmed

Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex.

NFYA SP1

1.56e-05636215647279
InteractionGTF2A1 interactions

NFYA SP1 SP2 GTF2A1 NCOA6 SP4 TAF4 TAF4B

8.02e-12104358int:GTF2A1
InteractionSRF interactions

NFYA NFYC BPTF SP1 SP2 NCOA6 FOXP4

3.65e-09139357int:SRF
InteractionSP2 interactions

NFYC SP1 SP2 GTF2A1 QRICH1

6.47e-0939355int:SP2
InteractionTBP interactions

NFYA NFYC SP1 GTF2A1 NCOA6 TAF4 TAF4B GTF2A1L

9.70e-09253358int:TBP
InteractionNFYC interactions

NFYA NFYC SP1 SP2 SP4 TAF4 MBTPS2

1.96e-08177357int:NFYC
InteractionPOU5F1 interactions

NFYC SOX5 BPTF SP1 FOXP4 TOX4 AMOTL2 RFX2 SCAF8

4.88e-07584359int:POU5F1
InteractionNFYA interactions

NFYA NFYC SP1 GTF2A1 QRICH1

1.00e-06105355int:NFYA
InteractionMKI67 interactions

SP1 NCOA6 CHD8 FOXP4 QRICH1 TOX4 CTCF LONP2 YLPM1

1.16e-06648359int:MKI67
InteractionSP4 interactions

NFYC SP1 GTF2A1 SP4

1.18e-0646354int:SP4
InteractionFEV interactions

SOX5 SP2 NCOA6 FOXP4 TAF4 CTCF

1.23e-06203356int:FEV
InteractionTAF11 interactions

NFYA NFYC TAF4 TAF4B

1.80e-0651354int:TAF11
InteractionELF1 interactions

NFYA NFYC BPTF SP1 TAF4

2.46e-06126355int:ELF1
InteractionSP1 interactions

NFYA NFYC SP1 SP2 GTF2A1 SP4 TAF4

2.62e-06365357int:SP1
InteractionFHL2 interactions

NFYC CCAR1 SP1 SP2 SP4 QRICH1 MAGEL2

4.49e-06396357int:FHL2
InteractionCREB1 interactions

NFYA SP1 GTF2A1 CHD8 TOX4 TAF4

4.51e-06254356int:CREB1
InteractionCRX interactions

NFYC SOX5 SP1 SP4 FOXP4 QRICH1

4.51e-06254356int:CRX
InteractionPOGZ interactions

NFYA NFYC SOX5 SP1 SP4 QRICH1

5.76e-06265356int:POGZ
InteractionYY1 interactions

BPTF SP1 CHD8 FOXP4 TOX4 TAF4 CTCF

1.10e-05454357int:YY1
InteractionGTF2A2 interactions

GTF2A1 TAF4 GTF2A1L

1.21e-0526353int:GTF2A2
InteractionSP7 interactions

SOX5 CCAR1 NCOA6 FOXP4 SCAF8 YLPM1

1.26e-05304356int:SP7
InteractionSMG7 interactions

CCAR1 TOMM20 NCOA6 CHD8 SCAF8 YLPM1

1.65e-05319356int:SMG7
InteractionKLF8 interactions

SOX5 BPTF SP1 FOXP4 TAF4 CTCF

1.97e-05329356int:KLF8
InteractionTAF12 interactions

NFYA NFYC TAF4 TAF4B

2.66e-05100354int:TAF12
InteractionPAX6 interactions

NFYC SOX5 BPTF NCOA6 QRICH1 CTCF

3.58e-05366356int:PAX6
InteractionTAF7 interactions

GTF2A1 CHD8 TAF4 TAF4B

3.59e-05108354int:TAF7
InteractionPRR20A interactions

NFYC SOX5 GTF2A1 SP4

3.73e-05109354int:PRR20A
InteractionELK3 interactions

SP2 SP4 FOXP4 TAF4

5.43e-05120354int:ELK3
InteractionTRB interactions

NCOA6 CTCF

6.12e-057352int:TRB
InteractionTAF6 interactions

NFYA NFYC SOX5 GTF2A1 TAF4

6.14e-05245355int:TAF6
InteractionTAF1 interactions

GTF2A1 CHD8 FOXP4 TAF4 TAF4B

8.14e-05260355int:TAF1
InteractionASH2L interactions

SP1 NCOA6 CHD8 TAF4 C21orf58

8.90e-05265355int:ASH2L
InteractionTBPL1 interactions

GTF2A1 TAF4 GTF2A1L

9.44e-0551353int:TBPL1
InteractionQRICH1 interactions

NFYA SP2 QRICH1 TOX4

9.88e-05140354int:QRICH1
InteractionNKX3-1 interactions

SP1 SP2 SP4

1.00e-0452353int:NKX3-1
InteractionSMAD3 interactions

NFYC BPTF SP1 NCOA6 CHD8 CTCF

1.08e-04447356int:SMAD3
InteractionRFXANK interactions

NFYC BPTF FOXP4 QRICH1

1.16e-04146354int:RFXANK
InteractionKLF15 interactions

NFYC SP2 FOXP4 TAF4 CTCF

1.36e-04290355int:KLF15
InteractionSF3A1 interactions

CCAR1 SP1 TOX4 TAF4 SYNE1 YLPM1

1.44e-04471356int:SF3A1
InteractionTAF4 interactions

NFYC SP1 GTF2A1 TAF4

1.50e-04156354int:TAF4
InteractionXRCC6 interactions

NFYA NFYC BPTF GTF2A1 NCOA6 CHD8 TOX4 YLPM1

1.52e-04928358int:XRCC6
InteractionTBPL2 interactions

NFYC GTF2A1

1.60e-0411352int:TBPL2
InteractionNFYB interactions

NFYA NFYC SP1

1.95e-0465353int:NFYB
InteractionPHAX interactions

NFYA CHD8 CTCF RAD23A

1.95e-04167354int:PHAX
InteractionCEBPA interactions

NFYA CCAR1 BPTF NCOA6 SP4 CHD8 QRICH1 TAF4 RAD23A

2.08e-041245359int:CEBPA
InteractionSETD1A interactions

NFYC NCOA6 CHD8 CTCF

2.09e-04170354int:SETD1A
InteractionATF6B interactions

NFYA NFYC MBTPS2

2.23e-0468353int:ATF6B
InteractionPOU2F1 interactions

NFYA SOX5 SP1 SP4

2.33e-04175354int:POU2F1
InteractionMAP7D2 interactions

TOMM20 LONP2 NEURL4

2.43e-0470353int:MAP7D2
InteractionFOXP2 interactions

SOX5 SP4 FOXP4

2.43e-0470353int:FOXP2
InteractionSMC5 interactions

CCAR1 BPTF NCOA6 CHD8 TOX4 TAF4 CTCF YLPM1

2.54e-041000358int:SMC5
InteractionGATA3 interactions

CCAR1 SP1 TOX4 CTCF

3.00e-04187354int:GATA3
InteractionKPNA1 interactions

CCAR1 BPTF CHD8 CTCF YLPM1

3.29e-04351355int:KPNA1
InteractionTERF2IP interactions

CCAR1 BPTF NCOA6 CHD8 TAF4 CTCF

3.39e-04552356int:TERF2IP
InteractionFOXJ2 interactions

NFYC QRICH1 RFX2

3.73e-0481353int:FOXJ2
InteractionARID4B interactions

NFYC SOX5 BPTF SP1

3.80e-04199354int:ARID4B
InteractionE2F1 interactions

SP1 SP2 NCOA6 SP4

3.87e-04200354int:E2F1
InteractionRETNLB interactions

LONP2 NEURL4

3.92e-0417352int:RETNLB
InteractionUSF1 interactions

NFYA BPTF CHD8

4.30e-0485353int:USF1
InteractionSPATA25 interactions

TAF4 TAF4B

4.41e-0418352int:SPATA25
InteractionDNAAF6 interactions

CCAR1 QRICH1

4.41e-0418352int:DNAAF6
InteractionTAF5 interactions

NFYC GTF2A1 TAF4

4.45e-0486353int:TAF5
InteractionPCGF1 interactions

SOX5 CCAR1 CTCF YLPM1

4.49e-04208354int:PCGF1
InteractionTLE3 interactions

CCAR1 RNF216 QRICH1 TAF4 SCAF8

4.51e-04376355int:TLE3
InteractionPRR20B interactions

NFYC GTF2A1 SP4

5.08e-0490353int:PRR20B
InteractionPRR20C interactions

NFYC GTF2A1 SP4

5.08e-0490353int:PRR20C
InteractionPRR20D interactions

NFYC GTF2A1 SP4

5.08e-0490353int:PRR20D
InteractionCEP76 interactions

NFYC EP400P1 NEURL4 RAD23A

5.36e-04218354int:CEP76
InteractionPOU3F2 interactions

NFYA NFYC

5.46e-0420352int:POU3F2
InteractionSOX2 interactions

SOX5 BPTF SP2 NCOA6 CHD8 FOXP4 AMOTL2 CTCF YLPM1

5.57e-041422359int:SOX2
InteractionNFIX interactions

SOX5 BPTF QRICH1 TAF4

6.24e-04227354int:NFIX
InteractionKLF3 interactions

SOX5 BPTF FOXP4 TAF4

6.34e-04228354int:KLF3
InteractionPRR20E interactions

NFYC GTF2A1 SP4

7.12e-04101353int:PRR20E
InteractionTAF4B interactions

GTF2A1 TAF4B

7.25e-0423352int:TAF4B
InteractionWWTR1 interactions

BPTF NCOA6 CHD8 TOX4 AMOTL2

7.60e-04422355int:WWTR1
InteractionNUP35 interactions

NCOA6 QRICH1 SCAF8 SYNE1 YLPM1

7.77e-04424355int:NUP35
InteractionHOXC11 interactions

SP1 GTF2A1L

7.90e-0424352int:HOXC11
InteractionCDC23 interactions

NFYC SOX5 TOMM20 TAF4

7.93e-04242354int:CDC23
InteractionBRD2 interactions

BPTF CHD8 TAF4 TAF4B CTCF

8.19e-04429355int:BRD2
InteractionEMX1 interactions

GTF2A1 GTF2A1L

8.57e-0425352int:EMX1
InteractionPML interactions

SP1 RNF216 SP2 TOMM20 CHD8 QRICH1 TAF4

9.61e-04933357int:PML
InteractionCIC interactions

NFYC SOX5 CCAR1 CHD8 TAF4 CTCF

9.63e-04673356int:CIC
InteractionMAFA interactions

TOMM20 NCOA6

1.00e-0327352int:MAFA
InteractionELF4 interactions

BPTF SP2 TAF4

1.04e-03115353int:ELF4
InteractionKLHDC7B interactions

NFYC QRICH1

1.08e-0328352int:KLHDC7B
InteractionTAF7L interactions

TAF4 TAF4B

1.08e-0328352int:TAF7L
InteractionATF6 interactions

NFYA NFYC SP1

1.09e-03117353int:ATF6
InteractionTOP1 interactions

NFYA NFYC CCAR1 NCOA6 TOX4 YLPM1

1.15e-03696356int:TOP1
InteractionSPANXN3 interactions

SP4 RAD23A

1.16e-0329352int:SPANXN3
InteractionHNF4A interactions

BPTF SP1 NCOA6 TAF4

1.27e-03275354int:HNF4A
InteractionBANP interactions

NFYA SP2 SP4 TOX4

1.31e-03277354int:BANP
InteractionBRMS1L interactions

SOX5 BPTF AMOTL2

1.32e-03125353int:BRMS1L
InteractionPROSER1 interactions

SOX5 TOMM20

1.32e-0331352int:PROSER1
InteractionPAX9 interactions

NCOA6 FOXP4 GTF2A1L

1.48e-03130353int:PAX9
InteractionZBTB7A interactions

SP1 SP4 CHD8

1.51e-03131353int:ZBTB7A
InteractionBRD3 interactions

BPTF CHD8 TAF4 TAF4B CTCF

1.53e-03494355int:BRD3
InteractionPARP1 interactions

NFYA NFYC BPTF SP1 NCOA6 QRICH1 CTCF RAD23A

1.56e-031316358int:PARP1
InteractionTLX3 interactions

SP1 NCOA6 FOXP4 GTF2A1L

1.57e-03291354int:TLX3
InteractionHSFY1 interactions

NFYC QRICH1

1.59e-0334352int:HSFY1
InteractionHCFC1 interactions

SP1 NCOA6 CHD8 TAF4

1.61e-03293354int:HCFC1
InteractionSOX13 interactions

SOX5 FOXP4

1.68e-0335352int:SOX13
CytobandXp22.11

SUPT20HL1 SUPT20HL2

1.24e-0421362Xp22.11
CytobandEnsembl 112 genes in cytogenetic band chrXp22

SUPT20HL1 SUPT20HL2 MBTPS2

9.97e-04250363chrXp22
CytobandEnsembl 112 genes in cytogenetic band chr6q25

SCAF8 SYNE1

7.38e-03164362chr6q25
Cytoband14q11.2

CHD8 TOX4

8.82e-0318036214q11.2
GeneFamilyZinc fingers C2H2-type|Sp transcription factors

SP1 SP2 SP4

6.93e-089183755
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

SP1 SP2 SP4 CTCF

4.84e-0371818428
CoexpressionGSE9988_LOW_LPS_VS_CTRL_TREATED_MONOCYTE_DN

SP1 NCOA6 CHD8 QRICH1 CTCF

7.65e-06200365M5870
CoexpressionKRAS.DF.V1_DN

SP1 SP2 TAF4 SYNE1

1.40e-04193364M2861
CoexpressionGSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN

NCOA6 CHD8 CTCF MYO1F

1.51e-04197364M5877
CoexpressionGSE11924_TFH_VS_TH1_CD4_TCELL_UP

SP1 CHD8 NEURL4 SCAF8

1.57e-04199364M3151
CoexpressionGSE6259_DEC205_POS_DC_VS_CD4_TCELL_DN

NFYA CCAR1 TOMM20 LONP2

1.60e-04200364M6774
CoexpressionGSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN

NCOA6 CHD8 CTCF MYO1F

1.60e-04200364M5851
CoexpressionGSE9988_LPS_VS_CTRL_TREATED_MONOCYTE_DN

NCOA6 CHD8 CTCF MYO1F

1.60e-04200364M5859
CoexpressionGSE27786_CD4_TCELL_VS_MONO_MAC_UP

NFYC TAF4B CTCF NEURL4

1.60e-04200364M4833
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000

SOX5 SP1 SP4 CHD8 TAF4B MBTPS2 CTCF RAD23A

3.14e-05806348gudmap_developingGonad_e12.5_epididymis_1000
ComputationalGenes in the cancer module 123.

NFYA SOX5 SP4 TOX4 TAF4 RFX2

2.73e-05247276MODULE_123
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

NFYC BPTF NCOA6 QRICH1 CTCF SCAF8

2.35e-071783467245_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

NFYC BPTF NCOA6 QRICH1 CTCF SCAF8

2.35e-071783461112_DN
DrugSP 0

SP1 SP2 SP4

3.62e-0710343CID002742752
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A_EA

BPTF NCOA6 AMOTL2 CTCF SCAF8

5.41e-061723451072_DN
DrugADP-ribosylarginine

SP1 SP2 SP4

6.84e-0625343CID000126311
DrugCamptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A

NFYA QRICH1 TAF4 CTCF SCAF8

7.12e-061823453887_DN
DrugTrazodone hydrochloride [25332-39-2]; Down 200; 9.8uM; MCF7; HT_HG-U133A

NFYC GTF2A1 AMOTL2 MBTPS2 YLPM1

1.13e-052003457410_DN
Drugaaptamine

SP1 SYNE1

1.30e-054342CID000122826
DrugSp 1 (pharmaceutical)

NFYC SP1 GTF2A1 SP4 TAF4 TAF4B CTCF

1.38e-05548347CID000099040
Drug3-(2-carboxyindol-3-yl)propionic acid

SP1 SP2 SP4

3.60e-0543343CID000169313
Drug2-pentene

SP2 SYNE1

7.74e-059342CID000012585
Drugcumulene

SP2 SYNE1

7.74e-059342CID006324998
Drugbis(hexamethylene)triamine

NFYA SP1 RFX2

7.99e-0556343CID000008924
DrugHBF4

SP2 SYNE1

9.67e-0510342CID000028118
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

NFYC BPTF CTCF SCAF8

9.93e-051633447453_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

BPTF NCOA6 CTCF SCAF8

1.17e-041703441050_DN
Drug1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane

SP1 SP4

1.18e-0411342ctd:C492909
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

NFYC QRICH1 CTCF SCAF8

1.19e-041713441234_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

NFYC BPTF CTCF SCAF8

1.25e-041733444665_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

NFYC BPTF CTCF SCAF8

1.25e-041733445950_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

NFYC QRICH1 CTCF SCAF8

1.28e-041743447105_DN
DrugSAHA; Down 200; 10uM; MCF7; HT_HG-U133A_EA

BPTF NCOA6 CTCF SCAF8

1.31e-041753441058_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

NFYC AMOTL2 CTCF SCAF8

1.34e-041763447499_DN
Drugtrichostatin A ; Down 200; 1uM; MCF7; HT_HG-U133A_EA

BPTF TAF4 AMOTL2 CTCF

1.34e-04176344981_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

BPTF NCOA6 CTCF SCAF8

1.34e-041763446932_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

BPTF SP2 CTCF SCAF8

1.36e-041773446340_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

NFYC BPTF QRICH1 CTCF

1.39e-04178344992_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

NFYC BPTF CTCF SCAF8

1.39e-041783445086_DN
DrugAC1L2HAX

SP1 SYNE1

1.42e-0412342CID000020942
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

NFYC BPTF CTCF SCAF8

1.46e-041803441793_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HG-U133A

BPTF NCOA6 CTCF SCAF8

1.52e-041823441891_DN
DrugGW8510; Down 200; 10uM; PC3; HT_HG-U133A

CHD8 TAF4 AMOTL2 CTCF

1.52e-041823447085_DN
DrugThioguanosine [85-31-4]; Up 200; 12.6uM; MCF7; HT_HG-U133A

SP1 SP2 AMOTL2 YLPM1

1.52e-041823444989_UP
DrugCamptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A

BPTF TAF4 CTCF SCAF8

1.58e-041843442321_DN
DrugPrimaquine diphosphate [63-45-6]; Down 200; 8.8uM; MCF7; HT_HG-U133A

NFYA TOX4 LONP2 YLPM1

1.65e-041863443279_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

BPTF NCOA6 CTCF SCAF8

1.83e-041913447503_DN
DrugCorynanthine hydrochloride [66634-44-4]; Down 200; 10.2uM; MCF7; HT_HG-U133A

NFYA RNF216 GTF2A1 TOX4

1.83e-041913444811_DN
Drughaloperidol; Down 200; 10uM; MCF7; HT_HG-U133A

NFYC GTF2A1 CHD8 RAD23A

1.83e-041913445200_DN
DrugAC1L1B35

SP1 SP2 SP4

1.83e-0474343CID000001263
DrugPindolol [13523-86-9]; Down 200; 16.2uM; PC3; HT_HG-U133A

NFYA MBTPS2 SYNE1 MYO1F

1.86e-041923444496_DN
Drug2-propylpentanoic acid; Down 200; 1000uM; MCF7; HT_HG-U133A

NFYA NFYC GTF2A1 MYO1F

1.86e-041923445206_DN
DrugColchicine [64-86-8]; Down 200; 10uM; MCF7; HT_HG-U133A

NFYA TOX4 MBTPS2 LONP2

1.90e-041933443213_DN
Drug(-)-Quinpirole hydrochloride [85760-74-3]; Down 200; 15.6uM; MCF7; HT_HG-U133A

NFYA MBTPS2 YLPM1 MYO1F

1.94e-041943447481_DN
DrugSimvastatin [79902-63-9]; Down 200; 9.6uM; PC3; HT_HG-U133A

SP1 GTF2A1 SYNE1 MYO1F

1.94e-041943444244_DN
DrugHydrastinine hydrochloride [4884-68-8]; Down 200; 16.4uM; PC3; HT_HG-U133A

NFYA SP1 TOX4 MBTPS2

1.94e-041943445075_DN
Drugacetoacetic ester

SP2 SYNE1

1.95e-0414342CID000008868
DrugPiribedil hydrochloride [78213-63-5]; Down 200; 12uM; HL60; HT_HG-U133A

NFYA SP1 TAF4B MBTPS2

2.02e-041963442951_DN
DrugGabexate mesilate [56974-61-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A

SP1 TOX4 TAF4B MBTPS2

2.02e-041963447357_DN
DrugBuspirone hydrochloride [33386-08-2]; Up 200; 9.4uM; HL60; HT_HG-U133A

NFYC SP1 TOX4 MBTPS2

2.06e-041973441282_UP
DrugTelenzepine dihydrochloride [147416-96-4]; Up 200; 9uM; MCF7; HT_HG-U133A

NFYA SP1 MBTPS2 LONP2

2.06e-041973447419_UP
DrugAtractyloside potassium salt [102130-43-8]; Down 200; 5uM; MCF7; HT_HG-U133A

RNF216 GTF2A1 LONP2 MYO1F

2.06e-041973444717_DN
DrugAC1L97MU

SP1 TAF4 GTF2A1L

2.06e-0477343CID000414413
DrugDihydroergocristine mesylate [24730-10-7]; Down 200; 5.6uM; PC3; HT_HG-U133A

NFYA RNF216 SP2 TOX4

2.10e-041983447275_DN
DrugMeropenem [96036-03-2]; Down 200; 10.4uM; MCF7; HT_HG-U133A

RNF216 MBTPS2 YLPM1 MYO1F

2.14e-041993443564_DN
Drugalpha-estradiol; Down 200; 0.01uM; PC3; HT_HG-U133A

NFYA RNF216 SYNE1 YLPM1

2.14e-041993441210_DN
Drug8-azaguanine

SP1 SP4 NEURL4

2.14e-0478343CID000008646
DrugStallimycin

NFYA SP1 GTF2A1

2.31e-0480343CID000003115
Drug2-methyleneglutarate

SP2 SYNE1

2.56e-0416342CID000095155
Drugbenzyl bromide

SP2 SYNE1

2.90e-0417342CID000007498
DrugDimethyl C7

SP1 SP4

3.26e-0418342CID000123994
Drugtrabectedin

NFYA NFYC

3.64e-0419342ctd:C099150
DiseaseIntellectual Disability

BPTF CHD8 QRICH1 CTCF SYNE1

2.00e-04447365C3714756
Diseasemood instability measurement

EYS QRICH1 YLPM1

5.13e-04128363EFO_0008475
Diseaseurate measurement, bone density

EYS QRICH1 TOX4 TAF4B SYNE1

8.80e-04619365EFO_0003923, EFO_0004531
DiseaseMalignant neoplasm of breast

NFYC GTF2A1 NCOA6 FOXP4 RFX2 SYNE1

1.75e-031074366C0006142
Diseasevery low density lipoprotein cholesterol measurement

BPTF SP4 MYO1F

3.90e-03260363EFO_0008317
Diseasebody weight

SOX5 BPTF CHD8 EYS TOX4 GTF2A1L

3.90e-031261366EFO_0004338
Diseasepulmonary function measurement

NFYC EP400P1

4.00e-0377362EFO_0003892
DiseaseAutism Spectrum Disorders

SOX5 CHD8

4.85e-0385362C1510586
Diseaseeye color

SOX5 EYS

5.42e-0390362EFO_0003949
Diseasemultisite chronic pain

SOX5 SP4

6.02e-0395362EFO_0010100

Protein segments in the cluster

PeptideGeneStartEntry
ILQAQVPPVFLQQQQ

AMOTL2

246

Q9Y2J4
QLQVQQPQQKIQIVP

CHD8

341

Q9HCK8
QPINIGELQLVQVPV

CTCF

106

P49711
QPLLQQPQQKAGLLQ

CCAR1

266

Q8IX12
RPQLQIQQPQPQVIA

BPTF

2546

Q12830
IQQPQPQVIAVPQLQ

BPTF

2551

Q12830
PQVIAVPQLQQQVQV

BPTF

2556

Q12830
QSGVPQQIKLQLPIQ

BPTF

2586

Q12830
QVIQQNPALLPALLQ

RAD23A

246

P54725
QPIQVQVQIQGQAPQ

QRICH1

131

Q2TAL8
LEQHGLTPQQIQIPQ

LONP2

531

Q86WA8
PQAQPLILQIQSQVI

MAGEL2

331

Q9UJ55
NQAVPQICPLQIQLG

EYS

71

Q5T1H1
IQGQLVQQQQVLQGP

EP400P1

261

Q6ZTU2
ILSPPQLQALLQQQQ

FOXP4

121

Q8IVH2
TTIQPGQIIIAQPQQ

NFYC

171

Q13952
PQGQVLLQQNPMIEQ

NCOA6

701

Q14686
IIQQLPQQPLIAQIP

C21orf58

211

P58505
QVLQVVVPGINLPVN

MBTPS2

141

O43462
LIQTLQIQQQKPQPS

SCAF8

206

Q9UPN6
QIQQQKPQPSILQAL

SCAF8

211

Q9UPN6
IVVINQPLVPQLLVQ

NEURL4

1161

Q96JN8
LQQIQLVPPGQIQIQ

NFYA

101

P23511
IPQAVQVKQLVVQQP

TAF4B

521

Q92750
QQIQLNPLQPVPVVK

TAF4

781

O00268
QVIPQLQTVEGQQIQ

SP4

166

Q02446
NSLQQVQIVGQPILQ

SP4

391

Q02446
VQIVGQPILQQIQIQ

SP4

396

Q02446
QPILQQIQIQQPQQQ

SP4

401

Q02446
QQGVQLPSVLRQQQP

SUPT20HL1

711

Q3ZLR7
IPLGPQNKQLLQQQA

SYNE1

1406

Q8NF91
LPRVQQVPQQVQPVQ

RFX2

51

P48378
LNQQPREITNQVVPQ

RNF216

181

Q9NWF9
QQQILIQPQLVQGGQ

SP1

396

P08047
LLLQPQPQPQQIQLQ

SUPT20HL2

756

P0C7V6
QPQPQQIQLQTQPLR

SUPT20HL2

761

P0C7V6
QIQLQTQPLRVLQQP

SUPT20HL2

766

P0C7V6
FQPQQSVVLQQQVIP

GTF2A1

176

P52655
LQHPIQQVFQQLGQP

GTF2A1L

151

Q9UNN4
IQVQPNLTNQIQIIP

SP2

146

Q02086
LQQYQQIIQPPPHIQ

YLPM1

416

P49750
QQQIQVQGQLPPLMI

SOX5

266

P35711
GQPQQLLQVLQQTLP

TOMM20

101

Q15388
TQQQVTILQQPPPLQ

TOX4

456

O94842
QVIGIPPSIQQLVLQ

MYO1F

261

O00160