Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	TRP_dom	TRPC4 TRPC5	4.11e-04	6	99	2	IPR013555
Domain	NUC	ENPP1 ENPP3	4.11e-04	6	99	2	SM00477
Domain	TRP_2	TRPC4 TRPC5	4.11e-04	6	99	2	PF08344
Domain	Endonuclease_NS	ENPP1 ENPP3	4.11e-04	6	99	2	SM00892
Domain	DNA/RNA_non-sp_Endonuclease	ENPP1 ENPP3	4.11e-04	6	99	2	IPR001604
Domain	-	ENPP1 ENPP3	4.11e-04	6	99	2	3.40.570.10
Domain	Endonuclease_NS	ENPP1 ENPP3	4.11e-04	6	99	2	PF01223
Domain	Extracellular_endonuc_su_A	ENPP1 ENPP3	4.11e-04	6	99	2	IPR020821
Domain	E-NPP	ENPP1 ENPP3	5.74e-04	7	99	2	IPR024873
Domain	TRPC_channel	TRPC4 TRPC5	5.74e-04	7	99	2	IPR002153
Domain	Somatomedin_B	ENPP1 ENPP3	7.63e-04	8	99	2	PF01033
Domain	SO	ENPP1 ENPP3	9.77e-04	9	99	2	SM00201
Domain	Somatomedin_B_dom	ENPP1 ENPP3	1.22e-03	10	99	2	IPR001212
Domain	SMB_1	ENPP1 ENPP3	1.22e-03	10	99	2	PS00524
Domain	SMB_2	ENPP1 ENPP3	1.22e-03	10	99	2	PS50958
Domain	Phosphodiest	ENPP1 ENPP3	1.22e-03	10	99	2	PF01663
Domain	HAT	SART3 ZFC3H1	1.22e-03	10	99	2	IPR003107
Domain	HAT	SART3 ZFC3H1	1.22e-03	10	99	2	SM00386
Domain	Phosphodiest/P_Trfase	ENPP1 ENPP3	1.22e-03	10	99	2	IPR002591
Domain	TRP_channel	TRPC4 TRPC5	1.48e-03	11	99	2	IPR004729
Domain	DOCK_C	DOCK4 DOCK10	1.48e-03	11	99	2	IPR010703
Domain	DHR-1_domain	DOCK4 DOCK10	1.48e-03	11	99	2	IPR027007
Domain	DHR_2	DOCK4 DOCK10	1.48e-03	11	99	2	PS51651
Domain	DHR_1	DOCK4 DOCK10	1.48e-03	11	99	2	PS51650
Domain	DOCK-C2	DOCK4 DOCK10	1.48e-03	11	99	2	PF14429
Domain	DHR-2	DOCK4 DOCK10	1.48e-03	11	99	2	IPR027357
Domain	DHR-2	DOCK4 DOCK10	1.48e-03	11	99	2	PF06920
Domain	DOCK	DOCK4 DOCK10	1.48e-03	11	99	2	IPR026791
Domain	-	PLA2R1 IGF2R	2.09e-03	13	99	2	2.10.10.10
Domain	FN_type2_col-bd	PLA2R1 IGF2R	2.43e-03	14	99	2	IPR000562
Domain	FN2_2	PLA2R1 IGF2R	2.43e-03	14	99	2	PS51092
Domain	fn2	PLA2R1 IGF2R	2.43e-03	14	99	2	PF00040
Domain	FN2_1	PLA2R1 IGF2R	2.43e-03	14	99	2	PS00023
Domain	FN2	PLA2R1 IGF2R	2.43e-03	14	99	2	SM00059
Pathway	REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM	ENPP1 ENPP3 FASN	1.10e-04	20	67	3	M538
Pathway	REACTOME_VLDL_ASSEMBLY	APOB P4HB	2.20e-04	5	67	2	M27760
Pathway	REACTOME_DISINHIBITION_OF_SNARE_FORMATION	STXBP3 PRKCG	2.20e-04	5	67	2	M26920
Pathway	REACTOME_VLDL_ASSEMBLY	APOB P4HB	2.20e-04	5	67	2	MM15505
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	SART3 MYBBP1A RPP30 KIF16B CCDC18 ZFC3H1 SIRT1 MPRIP PTPN13 IGF2R STXBP3 TIAM1 P4HB N4BP2 EIF2S3 EIF2A	7.71e-06	1487	103	16	33957083
Pubmed	Genomic structure and promoter analysis of the ecto-phosphodiesterase I gene (PDNP3) expressed in glial cells.	ENPP1 ENPP3	8.69e-06	2	103	2	10524196
Pubmed	Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors.	ENPP1 ENPP3	8.69e-06	2	103	2	21090681
Pubmed	Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes.	ENPP1 ENPP3	8.69e-06	2	103	2	9344668
Pubmed	Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-1 (E-NPP1/PC-1) and -3 (E-NPP3/CD203c/PD-Ibeta/B10/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases.	ENPP1 ENPP3	8.69e-06	2	103	2	15072822
Pubmed	[Effects of baicalin against oxidative stress injury of SH-SY5Y cells by up-regulating SIRT1].	CASP3 SIRT1	8.69e-06	2	103	2	22121772
Pubmed	C-reactive protein-bound enzymatically modified low-density lipoprotein does not transform macrophages into foam cells.	APOB CRP	8.69e-06	2	103	2	18322245
Pubmed	SIRT1-NOX4 signaling axis regulates cancer cachexia.	NOX4 SIRT1	8.69e-06	2	103	2	32441762
Pubmed	Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels.	TRPC4 TRPC5	8.69e-06	2	103	2	22457348
Pubmed	Conserved gating elements in TRPC4 and TRPC5 channels.	TRPC4 TRPC5	8.69e-06	2	103	2	23677990
Pubmed	Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells.	TRPC4 TRPC5	8.69e-06	2	103	2	32033274
Pubmed	Co-delivery of siPTPN13 and siNOX4 via (myo)fibroblast-targeting polymeric micelles for idiopathic pulmonary fibrosis therapy.	NOX4 PTPN13	8.69e-06	2	103	2	33537085
Pubmed	The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.	TRPC4 TRPC5	8.69e-06	2	103	2	17624425
Pubmed	Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation.	TRPC4 TRPC5	8.69e-06	2	103	2	34899056
Pubmed	Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain.	TRPC4 TRPC5	8.69e-06	2	103	2	17593972
Pubmed	Identification of hydrolytically stable and selective P2Y(1) receptor agonists.	ENPP1 ENPP3	8.69e-06	2	103	2	18760862
Pubmed	C-reactive protein levels are inversely correlated with the apolipoprotein B-48-containing triglyceride-rich lipoprotein production rate in insulin resistant men.	APOB CRP	8.69e-06	2	103	2	28183448
Pubmed	Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice.	TRPC4 TRPC5	8.69e-06	2	103	2	26317356
Pubmed	A novel capacitative calcium entry channel expressed in excitable cells.	TRPC4 TRPC5	8.69e-06	2	103	2	9687496
Pubmed	Ectonucleotide pyrophosphatase/phosphodiesterase activity in Neuro-2a neuroblastoma cells: changes in expression associated with neuronal differentiation.	ENPP1 ENPP3	8.69e-06	2	103	2	24947519
Pubmed	Capsaicin inhibits cell proliferation by enhancing oxidative stress and apoptosis through SIRT1/NOX4 signaling pathways in HepG2 and HL-7702 cells.	NOX4 SIRT1	8.69e-06	2	103	2	34939720
Pubmed	A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination.	PPP2R5A BRCA2	8.69e-06	2	103	2	34593815
Pubmed	Differential role of SIRT1/MAPK pathway during cerebral ischemia in rats and humans.	CASP3 SIRT1	8.69e-06	2	103	2	33737560
Pubmed	Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility.	CFAP47 CFAP65	8.69e-06	2	103	2	33472045
Pubmed	Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts.	SIRT1 IGF2R	8.69e-06	2	103	2	27167200
Pubmed	TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.	TRPC4 TRPC5	8.69e-06	2	103	2	30038709
Pubmed	Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion.	APOB FASN P4HB	1.37e-05	16	103	3	38042368
Pubmed	Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains.	LRRC8C DGKQ APOB	1.66e-05	17	103	3	17496333
Pubmed	Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory.	TRPC4 TRPC5	2.60e-05	3	103	2	28790178
Pubmed	A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression.	SIRT1 CRP	2.60e-05	3	103	2	21176092
Pubmed	Differential PI(4,5)P2 sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels.	TRPC4 TRPC5	2.60e-05	3	103	2	30755645
Pubmed	SIRT1 associates with eIF2-alpha and regulates the cellular stress response.	SIRT1 EIF2A	2.60e-05	3	103	2	22355666
Pubmed	Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes.	ENPP1 ENPP3	2.60e-05	3	103	2	10513816
Pubmed	A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease.	TRPC5 NOX4	2.60e-05	3	103	2	29793963
Pubmed	Prognostic utility of apoB/AI, total cholesterol/HDL, non-HDL cholesterol, or hs-CRP as predictors of clinical risk in patients receiving statin therapy after acute coronary syndromes: results from PROVE IT-TIMI 22.	APOB CRP	2.60e-05	3	103	2	19122170
Pubmed	Radiation enhances caspase 3 cleavage of Rad51 in BRCA2-defective cells.	CASP3 BRCA2	2.60e-05	3	103	2	18439040
Pubmed	C-reactive protein promotes tongue squamous cell carcinoma chemoresistance by inhibiting the activation of caspase-3/9 via the CD64/AKT/mTOR pathway.	CASP3 CRP	2.60e-05	3	103	2	34019244
Pubmed	Metabolic syndrome and carotid intima-media thickness in young adults: roles of apolipoprotein B, apolipoprotein A-I, C-reactive protein, and secretory phospholipase A2: the cardiovascular risk in young Finns study.	APOB CRP	2.60e-05	3	103	2	20539018
Pubmed	Regulation of TRPC1 and TRPC4 cation channels requires an alpha1-syntrophin-dependent complex in skeletal mouse myotubes.	TRPC4 SNTA1	2.60e-05	3	103	2	19812031
Pubmed	Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma.	TRPC4 TRPC5	2.60e-05	3	103	2	34199280
Pubmed	Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein Function.	APOB P4HB	2.60e-05	3	103	2	26224785
Pubmed	GDF11 OVEREXPRESSION ALLEVIATES SEPSIS-INDUCED LUNG MICROVASCULAR ENDOTHELIAL BARRIER DAMAGE BY ACTIVATING SIRT1/NOX4 SIGNALING TO INHIBIT FERROPTOSIS.	NOX4 SIRT1	2.60e-05	3	103	2	38920138
Pubmed	miR‑195 promotes LPS‑mediated intestinal epithelial cell apoptosis via targeting SIRT1/eIF2a.	SIRT1 EIF2A	2.60e-05	3	103	2	31894250
Pubmed	Loss of angiotensin II receptor expression in dopamine neurons in Parkinson's disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation.	CASP3 NOX4	2.60e-05	3	103	2	25645462
Pubmed	Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia.	APOB CRP	2.60e-05	3	103	2	17702862
Pubmed	The protective effect of small peptides from Periplaneta americana on hydrogen peroxide-induced apoptosis of granular cells.	CASP3 SIRT1	2.60e-05	3	103	2	34155600
Pubmed	TRPC1/4/5 channels contribute to morphine-induced analgesic tolerance and hyperalgesia by enhancing spinal synaptic potentiation and structural plasticity.	TRPC4 TRPC5	2.60e-05	3	103	2	32359120
Pubmed	Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion.	APOB P4HB	2.60e-05	3	103	2	38211723
Pubmed	Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase activity.	CASP3 NEK5	2.60e-05	3	103	2	23727203
Pubmed	Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.	TRPC4 TRPC5	2.60e-05	3	103	2	28325835
Pubmed	Dual action of the Gαq-PLCβ-PI(4,5)P2 pathway on TRPC1/4 and TRPC1/5 heterotetramers.	TRPC4 TRPC5	2.60e-05	3	103	2	30108272
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	SART3 MYBBP1A RPP30 CASP3 DHX33 LAP3 FASN SUGP2 EIF2S3 EIF2A	4.71e-05	704	103	10	29955894
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DOCK4 CCDC18 MPRIP STOX2 PTPN13 TIAM1 STARD9 N4BP2 RABGAP1L PRKCG OTOG	5.06e-05	861	103	11	36931259
Pubmed	Interaction with dopamine D2 receptor enhances expression of transient receptor potential channel 1 at the cell surface.	TRPC4 TRPC5	5.19e-05	4	103	2	18261457
Pubmed	The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5.	TRPC4 TRPC5	5.19e-05	4	103	2	20164195
Pubmed	Novel missense MTTP gene mutations causing abetalipoproteinemia.	APOB P4HB	5.19e-05	4	103	2	25108285
Pubmed	NMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells.	TRPC4 TRPC5	5.19e-05	4	103	2	22539836
Pubmed	Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis.	TRPC4 TRPC5	5.19e-05	4	103	2	32110987
Pubmed	Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms.	TRPC4 TRPC5	5.19e-05	4	103	2	23188715
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	CNNM2 TNPO2 VPS26C LAP3 PTPN13 IGF2R STXBP3 SUGP2 P4HB CHPF2	8.32e-05	754	103	10	33060197
Pubmed	Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle.	ENPP1 ENPP3	8.64e-05	5	103	2	21490328
Pubmed	Formation of novel TRPC channels by complex subunit interactions in embryonic brain.	TRPC4 TRPC5	8.64e-05	5	103	2	12857742
Pubmed	Enhanced capacitative calcium entry and TRPC channel gene expression in human LES smooth muscle.	TRPC4 TRPC5	8.64e-05	5	103	2	12736151
Pubmed	Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF.	TRPC4 TRPC5	8.64e-05	5	103	2	10980202
Pubmed	TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling.	TRPC4 TRPC5	8.64e-05	5	103	2	20458742
Pubmed	The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration.	SIRT1 TIAM1	8.64e-05	5	103	2	24362520
Pubmed	Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157.	SART3 RNF157	8.64e-05	5	103	2	25342469
Pubmed	Macrophage-specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP-9 pathways.	NOX4 SIRT1	8.64e-05	5	103	2	25116588
Pubmed	Regulation of PERK-eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes.	CASP3 FASN EIF2A	1.29e-04	33	103	3	27416896
Pubmed	Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression.	CASP3 BRCA2	1.29e-04	6	103	2	21404276
Pubmed	Calcium Channels Formed by Mammalian Trp Homologues.	TRPC4 TRPC5	1.29e-04	6	103	2	11390792
Pubmed	trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.	TRPC4 TRPC5	1.29e-04	6	103	2	8646775
Pubmed	TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses.	TRPC4 TRPC5	1.29e-04	6	103	2	31536487
Pubmed	TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.	TRPC4 TRPC5	1.29e-04	6	103	2	32414784
Pubmed	Acetylation of alpha-fetoprotein promotes hepatocellular carcinoma progression.	CASP3 SIRT1	1.29e-04	6	103	2	31811908
Pubmed	Alteration of DNA Damage Response Causes Cleft Palate.	CASP3 BRCA2	1.29e-04	6	103	2	33854442
Pubmed	TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation.	TRPC4 TRPC5	1.29e-04	6	103	2	29373286
Pubmed	Endoplasmic Reticulum-associated Degradation of Pca1p, a Polytopic Protein, via Interaction with the Proteasome at the Membrane.	ENPP1 HMGB2	1.29e-04	6	103	2	27226596
Pubmed	Transient receptor potential channels and their role in modulating radial glial-neuronal interaction: a signaling pathway involving mGluR5.	TRPC4 TRPC5	1.29e-04	6	103	2	25347706
Pubmed	RNF41 interacts with the VPS52 subunit of the GARP and EARP complexes.	ASB6 VPS53	1.29e-04	6	103	2	28542518
Pubmed	Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice.	TRPC4 TRPC5	1.29e-04	6	103	2	36476978
Pubmed	CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development.	CASP3 P4HB EIF2A	1.68e-04	36	103	3	30635284
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	SART3 MYBBP1A MPRIP FASN SUGP2 EIF2S3	1.71e-04	274	103	6	34244482
Pubmed	MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.	TRPC4 TRPC5	1.81e-04	7	103	2	15757897
Pubmed	Mechanism of stretch-induced activation of the mechanotransducer zyxin in vascular cells.	TRPC4 TRPC5	1.81e-04	7	103	2	23233529
Pubmed	TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis.	TRPC4 TRPC5	1.81e-04	7	103	2	36592529
Pubmed	Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models.	TRPC4 TRPC5	1.81e-04	7	103	2	15336983
Pubmed	HIV gp120- and methamphetamine-mediated oxidative stress induces astrocyte apoptosis via cytochrome P450 2E1.	CASP3 NOX4	1.81e-04	7	103	2	24113184
Pubmed	RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways.	TRPC4 TRPC5	1.81e-04	7	103	2	32350291
Pubmed	TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer.	TRPC4 TRPC5	1.81e-04	7	103	2	38835669
Pubmed	Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes.	TRPC4 TRPC5	1.81e-04	7	103	2	36257322
Pubmed	Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency.	SIRT1 BRCA2	1.81e-04	7	103	2	34750509
Pubmed	Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.	TM9SF3 SIRT1 P4HB SCPEP1 CHPF2 NXPH4	2.00e-04	282	103	6	35007762
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DOCK4 DOCK10 RNF157 SUGP2 STARD9 RABGAP1L CHPF2	2.16e-04	407	103	7	12693553
Pubmed	Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells.	CASP3 HMGB2	2.40e-04	8	103	2	17008916
Pubmed	Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels.	TRPC4 TRPC5	2.40e-04	8	103	2	25471572
Pubmed	Association of immunophilins with mammalian TRPC channels.	TRPC4 TRPC5	2.40e-04	8	103	2	15199065
Pubmed	Subunit composition of mammalian transient receptor potential channels in living cells.	TRPC4 TRPC5	2.40e-04	8	103	2	12032305
Pubmed	The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis.	SIRT1 IGF2R	2.40e-04	8	103	2	12482959
Pubmed	FBXL6 degrades phosphorylated p53 to promote tumor growth.	MYBBP1A FASN	2.40e-04	8	103	2	33568778
Drug	adenosine diphosphoribose	ENPP1 ENPP3 TRPC4 TRPC5 CASP3 SIRT1	3.85e-06	92	103	6	CID000030243
Drug	NSC285223	ENPP1 ENPP3 LAP3	1.05e-05	10	103	3	CID000323607
Drug	ethyl gallate	ENPP1 ENPP3 BCO1	1.92e-05	12	103	3	CID000013250
Drug	pinicolic acid	ENPP1 ENPP3	2.03e-05	2	103	2	CID005320604
Drug	isodApdC	ENPP1 ENPP3	2.03e-05	2	103	2	CID000477021
Drug	5-iodoindoxyl-3-phenylphosphonate	ENPP1 ENPP3	2.03e-05	2	103	2	CID000126064
Disease	Diabetic Retinopathy	CASP3 SIRT1 CRP	5.93e-06	11	99	3	C0011884
Disease	cardiovascular system disease (is_marker_for)	APOB CRP	4.93e-04	10	99	2	DOID:1287 (is_marker_for)
Disease	Congestive heart failure	NOX4 SIRT1 CRP FASN	5.24e-04	110	99	4	C0018802
Disease	Heart failure	NOX4 SIRT1 CRP FASN	5.24e-04	110	99	4	C0018801
Disease	Left-Sided Heart Failure	NOX4 SIRT1 CRP FASN	5.24e-04	110	99	4	C0023212
Disease	Heart Failure, Right-Sided	NOX4 SIRT1 CRP FASN	5.24e-04	110	99	4	C0235527
Disease	Heart Decompensation	NOX4 SIRT1 CRP FASN	5.24e-04	110	99	4	C1961112
Disease	Myocardial Failure	NOX4 SIRT1 CRP FASN	5.24e-04	110	99	4	C1959583
Disease	Kidney Failure, Chronic	NOX4 CRP FASN	5.68e-04	48	99	3	C0022661
Disease	Obesity	ENPP1 HMGB2 SIRT1 CRP FASN	6.50e-04	205	99	5	C0028754
Disease	nicotine dependence (implicated_via_orthology)	TRPC4 TRPC5	7.20e-04	12	99	2	DOID:0050742 (implicated_via_orthology)
Disease	amyotrophic lateral sclerosis (biomarker_via_orthology)	CASP3 IGF2R	8.48e-04	13	99	2	DOID:332 (biomarker_via_orthology)
Disease	nephroblastoma (is_implicated_in)	IGF2R BRCA2	9.88e-04	14	99	2	DOID:2154 (is_implicated_in)
Disease	rostral middle frontal gyrus volume measurement	ARRDC1 PLA2R1	9.88e-04	14	99	2	EFO_0010328
Disease	Hypertriglyceridemia	APOB CRP	1.14e-03	15	99	2	C0020557
Disease	breast carcinoma (is_marker_for)	CASP3 CRP IGF2R	1.44e-03	66	99	3	DOID:3459 (is_marker_for)
Disease	emphysema imaging measurement	KIF16B CCDC18 TIAM1 ZNF770	1.50e-03	146	99	4	EFO_0007626
Disease	Liver carcinoma	HMGB2 RNF157 CRP FAM111B RND3 FASN IGF2R	1.62e-03	507	99	7	C2239176
Disease	food allergy measurement, parental genotype effect measurement	DCHS2 EML6	1.65e-03	18	99	2	EFO_0005939, EFO_0007016
Disease	thrombin activatable fibrinolysis inhibitor activation peptide measurement	DOCK10 SLC5A12	1.84e-03	19	99	2	EFO_0008582
Disease	atherosclerosis (biomarker_via_orthology)	CASP3 SIRT1	2.04e-03	20	99	2	DOID:1936 (biomarker_via_orthology)
Disease	Metabolic Syndrome X	SIRT1 CRP	2.24e-03	21	99	2	C0524620
Disease	impotence (biomarker_via_orthology)	CASP3 SIRT1	2.46e-03	22	99	2	DOID:1875 (biomarker_via_orthology)
Disease	body weight loss	PKHD1 SLC38A6	2.46e-03	22	99	2	EFO_0005245

Protein segments in the cluster

Peptide	Gene	Start	Entry
SNKECSFLHVKPAFK	CPSF4L	106	A6NMK7
HSFRKVTLTKPTFCH	DGKQ	61	P52824
SLTHICLKSFKLHFP	ASB6	261	Q9NWX5
ICFKHSKFSLLSVNP	ANGEL2	256	Q5VTE6
SFRAPNHTKFSCKFT	ATP4B	141	P51164
SFDATFHAKKQIPCI	CASP3	251	P42574
HTPRFSKDHKCSLVF	ARRDC1	116	Q8N5I2
EFEEALFCHTKSFPI	ABHD15	316	Q6UXT9
LKSFHKPVTSYQEAC	POLL	286	Q9UGP5
TLSKHTICEFSPFFK	KIF16B	1291	Q96L93
AKPFKVICIFVSFLS	NXPH4	271	O95158
TKEFNFLKCSVPLHS	PCDHGB6	761	Q9Y5F9
HKPKCFSDFIELLTL	SLC7A8	471	Q9UHI5
KQSVHCFKESLPTYE	PLA2G2C	116	Q5R387
ACTAAAFLKEFVTHP	LAP3	461	P28838
LSFIDFCHSTVITPK	OR8G1	66	Q15617
LSFIDFCHSTVITPK	OR8G5	101	Q8NG78
TTDPAFFCKLHFIKG	MIR7-3HG	96	Q8N6C7
APLFSLTEESFKACH	LRRC55	236	Q6ZSA7
KFSLCILTPEKEHFI	MPRIP	116	Q6WCQ1
KFLHKVFCSVTILSF	GPR176	121	Q14439
AFFLFCSEHRPKIKS	HMGB2	101	P26583
KFCFDAISHTSPVTL	GALNT10	521	Q86SR1
KKCVSVFFHPKTLDT	CFAP65	421	Q6ZU64
EKVDLHPQLCFKFSF	IL17RE	331	Q8NFR9
NLISTDFSPKLHFKF	ISM2	511	Q6H9L7
KAFEKLHCPEAGFST	NEK5	631	Q6P3R8
VPLKTQCTFIKFFLH	DNAH12	1756	Q6ZR08
LIPTHFFIVLTSCKD	ENPP1	826	P22413
HKFTARFFKQPTFCS	PRKCG	36	P05129
KVHSFPTLKFFPASA	P4HB	436	P07237
ARFCLFHSFFVTKKP	MYBBP1A	476	Q9BQG0
SKPAEFTQHKFVKIC	NOX4	256	Q9NPH5
LTLFTAKFPLCMVFH	RABGAP1L	701	Q5R372
LSFVDICFSFTTVPK	OR1F1	66	O43749
HSPKSDSKFASCTVF	DCHS2	2961	Q6V1P9
CFFSGSTPINSKKHI	SCYL3	466	Q8IZE3
KLTSFKAVHFSPVSS	GLYATL3	126	Q5SZD4
SLPDFKELCTISHIF	APOB	3316	P04114
KHVFASLRLFVCKFP	DOCK10	1536	Q96BY6
IFPSSYVHLKNACVK	DOCK4	56	Q8N1I0
DKSVVCGSLFHTPKF	BRCA2	156	P51587
VQDPKFAKCFHTSFS	CCDC18	1331	Q5T9S5
FVVLTSCKNKSHTPE	ENPP3	781	O14638
KPLKAFTVCLHFYTE	CRP	46	P02741
FAKTILMSPKFHCTE	DHX33	506	Q9H6R0
CTKPLHQVFASFTRK	CENPO	276	Q9BU64
VKLFDFPCTEKFAKH	EML6	1906	Q6ZMW3
HSFDLLKAVCLEFSP	EIF2A	71	Q9BY44
PLKCLPSDSHFKITF	FAM111B	146	Q6SJ93
ISKTFCPAHKSYIIA	FASN	1876	P49327
HKLFISGLPFSCTKE	SART3	801	Q15020
CHLSFKSSKPVSFFT	CFAP47	1381	Q6ZTR5
KSSKPVSFFTNLLFC	CFAP47	1386	Q6ZTR5
NCAPSFSYVKHLVKL	PTPN13	161	Q12923
KTALLHVFAKDCFPE	RND3	36	P61587
KETFPGVTALFCKAH	MR1	211	Q95460
PFDFVGACKVHLVKS	OTOG	1001	Q6ZRI0
IKHFFCDTQPVLKLS	OR1L6	211	Q8NGR2
LSFIDFCHSTVITPK	OR8G3P	66	P0DMU2
FPKTEKLFHIACTHL	RPP30	106	P78346
KTKSVSSTIFFHCDP	IGF2R	2236	P11717
TFEKHTDGTFCVKPL	RNF157	221	Q96PX1
SCPKTIVFIIHSFLS	SNTA1	481	Q13424
LKTFFSCHKEFQTVP	SCPEP1	146	Q9HB40
FHEAKAAKSSTFLPT	NEXMIF	776	Q5QGS0
ISNVTDDCKPKLFHF	SLC38A6	231	Q8IZM9
PEKVLKHFCSITSLF	SHOC1	1086	Q5VXU9
FQPSLCHKFIALSDK	SIRT1	321	Q96EB6
SCTFKFSKAQTPIVH	PKHD1	126	P08F94
LFDIHKACKSQTPSE	POMK	306	Q9H5K3
PFICHSSSSEIIEKK	STARD9	2691	Q9P2P6
KLACSHDFTFEIIPA	OR5P3	186	Q8WZ94
ITPTSKSVDCFLHDF	STXBP3	81	O00186
EPGLASCFKVFHSEK	PLA2R1	671	Q13018
PLFKQISKCVSSSHF	PPP2R5A	351	Q15172
PCKNIFSKAFSYLSH	BCO1	101	Q9HAY6
DKSKITVPFLKHGFC	CCDC110	221	Q8TBZ0
SKKHPVDTLFFLTTV	CHPF2	581	Q9P2E5
VSFNFSTVHKSCPAK	CLECL1	106	Q8IZS7
DDCTPLKTITKFYNH	CNNM2	506	Q9H8M5
IFKTPKELSCTHVFC	RNF223	61	E7ERA6
VVKSCAQTFPKLDTF	ZNF341	476	Q9BYN7
PECGKFFSHKSTLSQ	ZNF33B	556	Q06732
LYSAFCASHTKVPKV	TIAM1	1141	Q13009
KLFHSTDTKSVVCPI	RNF114	161	Q9Y508
EIFSKDTLFKPLHST	STOX2	696	Q9P2F5
KFLQFFKHCSPKIRS	TNPO2	176	O14787
CFFTIKFLKHSALKT	SUGP2	381	Q8IX01
SFHKFPLTRPSLCKE	THAP1	21	Q9NVV9
ANSFIPKFITHLFKC	VPS53	671	Q5VIR6
ICFKHFETPSKLARH	ZNF770	31	Q6IQ21
FSLPFCVGSKKSISH	TM9SF3	61	Q9HD45
VKSFHCSGPVKFTIV	TMEM87B	76	Q96K49
KKPFIKFICHTASYL	TRPC5	361	Q9UL62
FPTAEVLLSAFHICK	ZSWIM1	161	Q9BR11
NVTKFTKLHCFPLLE	SLC9A7	346	Q96T83
FEDFVKSCFPHLSDK	SLC5A12	361	Q1EHB4
FYLSCVPKTQHSKTL	ZFC3H1	1846	O60293
QFFHPCKKLFSSSVS	XK	371	P51811
KPFIKFICHTASYLT	TRPC4	361	Q9UBN4
TCEFIVHSAPQKGKF	VPS26C	136	O14972
TLVHKFACKFSEPVY	TRIM16L	301	Q309B1
CKPIFSKIVSLFAEH	EIF2S3	311	P41091
FKFPGSSSKIEHFIS	LRRC8C	146	Q8TDW0
PSHSVLNESKCFIKD	N4BP2	216	Q86UW6