Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-tRNA ligase activity	CARS1 CARS2	2.38e-05	2	98	2	GO:0004817
GeneOntologyMolecularFunction	axon guidance receptor activity	EPHB2 PTK7 HMCN2	3.16e-05	13	98	3	GO:0008046
GeneOntologyMolecularFunction	phospholipase D activator activity	ARF1 ARF4	7.13e-05	3	98	2	GO:1990583
GeneOntologyMolecularFunction	beta-catenin binding	DACT2 CHD8 KDM6B AJAP1 NOS3	3.14e-04	120	98	5	GO:0008013
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM5C KDM5D KDM6B	3.44e-04	28	98	3	GO:0141052
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5C KDM5D	3.53e-04	6	98	2	GO:0034647
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	CYP8B1 KDM5C KDM5D KDM6B MICAL2 NOS3	3.91e-04	194	98	6	GO:0016705
GeneOntologyMolecularFunction	histone demethylase activity	KDM5C KDM5D KDM6B	4.66e-04	31	98	3	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	KDM5C KDM5D KDM6B	5.13e-04	32	98	3	GO:0140457
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5C KDM5D	6.55e-04	8	98	2	GO:0032453
GeneOntologyMolecularFunction	microfilament motor activity	MYO1A MYH7B MYO1B	8.54e-04	38	98	3	GO:0000146
GeneOntologyMolecularFunction	ligase activity, forming carbon-oxygen bonds	EPRS1 CARS1 CARS2	1.15e-03	42	98	3	GO:0016875
GeneOntologyMolecularFunction	aminoacyl-tRNA ligase activity	EPRS1 CARS1 CARS2	1.15e-03	42	98	3	GO:0004812
GeneOntologyMolecularFunction	demethylase activity	KDM5C KDM5D KDM6B	1.31e-03	44	98	3	GO:0032451
GeneOntologyMolecularFunction	NAD(P)H oxidase H2O2-forming activity	NOX1 MICAL2	1.52e-03	12	98	2	GO:0016174
Domain	ARF	ARF1 ARF3 ARF4 ARF5	1.47e-05	29	97	4	PS51417
Domain	Small_GTPase_ARF	ARF1 ARF3 ARF4 ARF5	1.47e-05	29	97	4	IPR024156
Domain	Arf	ARF1 ARF3 ARF4 ARF5	1.93e-05	31	97	4	PF00025
Domain	Small_GTPase_ARF/SAR	ARF1 ARF3 ARF4 ARF5	2.49e-05	33	97	4	IPR006689
Domain	Cys-tRNA-ligase	CARS1 CARS2	2.67e-05	2	97	2	IPR015803
Domain	Cys-tRNA/MSH_ligase	CARS1 CARS2	2.67e-05	2	97	2	IPR024909
Domain	tRNA-synt_1_cat_dom	CARS1 CARS2	2.67e-05	2	97	2	IPR032678
Domain	-	KDM5C KDM5D ARID2	5.91e-05	15	97	3	1.10.150.60
Domain	BRIGHT	KDM5C KDM5D ARID2	5.91e-05	15	97	3	SM00501
Domain	ARID_dom	KDM5C KDM5D ARID2	5.91e-05	15	97	3	IPR001606
Domain	ARID	KDM5C KDM5D ARID2	5.91e-05	15	97	3	PS51011
Domain	ARID	KDM5C KDM5D ARID2	5.91e-05	15	97	3	PF01388
Domain	Ig_I-set	ROBO4 OBSCN OBSL1 IGDCC3 PTK7 HMCN2 CD22	5.99e-05	190	97	7	IPR013098
Domain	I-set	ROBO4 OBSCN OBSL1 IGDCC3 PTK7 HMCN2 CD22	5.99e-05	190	97	7	PF07679
Domain	tRNA-synt_1e	CARS1 CARS2	7.98e-05	3	97	2	PF01406
Domain	AA_TRNA_LIGASE_I	EPRS1 CARS1 CARS2	1.24e-04	19	97	3	PS00178
Domain	Lys_sp_deMease-like_dom	KDM5C KDM5D	1.59e-04	4	97	2	IPR013637
Domain	PLU-1	KDM5C KDM5D	1.59e-04	4	97	2	PF08429
Domain	IGc2	ROBO4 OBSCN OBSL1 IGDCC3 PTK7 HMCN2 CD22	2.24e-04	235	97	7	SM00408
Domain	Ig_sub2	ROBO4 OBSCN OBSL1 IGDCC3 PTK7 HMCN2 CD22	2.24e-04	235	97	7	IPR003598
Domain	JmjC	KDM5C KDM5D KDM6B	2.54e-04	24	97	3	PF02373
Domain	zf-C5HC2	KDM5C KDM5D	2.64e-04	5	97	2	PF02928
Domain	Znf_C5HC2	KDM5C KDM5D	2.64e-04	5	97	2	IPR004198
Domain	Myosin_TH1	MYO1A MYO1B	5.51e-04	7	97	2	PF06017
Domain	Myosin_TH1	MYO1A MYO1B	5.51e-04	7	97	2	IPR010926
Domain	TH1	MYO1A MYO1B	5.51e-04	7	97	2	PS51757
Domain	JMJC	KDM5C KDM5D KDM6B	6.04e-04	32	97	3	PS51184
Domain	JmjC_dom	KDM5C KDM5D KDM6B	6.04e-04	32	97	3	IPR003347
Domain	JmjC	KDM5C KDM5D KDM6B	6.62e-04	33	97	3	SM00558
Domain	IQ	MYO1A MYH7B OBSCN MYO1B	8.38e-04	81	97	4	SM00015
Domain	Myosin_head_motor_dom	MYO1A MYH7B MYO1B	1.00e-03	38	97	3	IPR001609
Domain	MYOSIN_MOTOR	MYO1A MYH7B MYO1B	1.00e-03	38	97	3	PS51456
Domain	Myosin_head	MYO1A MYH7B MYO1B	1.00e-03	38	97	3	PF00063
Domain	MYSc	MYO1A MYH7B MYO1B	1.00e-03	38	97	3	SM00242
Domain	JmjN	KDM5C KDM5D	1.17e-03	10	97	2	SM00545
Domain	JmjN	KDM5C KDM5D	1.17e-03	10	97	2	PF02375
Domain	JMJN	KDM5C KDM5D	1.17e-03	10	97	2	PS51183
Domain	JmjN	KDM5C KDM5D	1.17e-03	10	97	2	IPR003349
Domain	PHD	TCF20 KDM5C CHD3 KDM5D	1.19e-03	89	97	4	SM00249
Domain	IQ_motif_EF-hand-BS	MYO1A MYH7B OBSCN MYO1B	1.24e-03	90	97	4	IPR000048
Domain	Znf_PHD	TCF20 KDM5C CHD3 KDM5D	1.29e-03	91	97	4	IPR001965
Domain	IQ	MYO1A MYH7B OBSCN MYO1B	1.40e-03	93	97	4	PS50096
Domain	Rossmann-like_a/b/a_fold	EPRS1 CARS1 CARS2	1.44e-03	43	97	3	IPR014729
Domain	-	EPRS1 CARS1 CARS2	1.44e-03	43	97	3	3.40.50.620
Domain	ZF_PHD_2	TCF20 KDM5C CHD3 KDM5D	1.52e-03	95	97	4	PS50016
Domain	fn3	EPHB2 ROBO4 OBSCN OBSL1 IGDCC3	1.57e-03	162	97	5	PF00041
Domain	IG	MPZ ROBO4 OBSCN OBSL1 IGDCC3 PTK7 HMCN2 CD22	1.57e-03	421	97	8	SM00409
Domain	Ig_sub	MPZ ROBO4 OBSCN OBSL1 IGDCC3 PTK7 HMCN2 CD22	1.57e-03	421	97	8	IPR003599
Domain	ZF_PHD_1	TCF20 KDM5C CHD3 KDM5D	1.58e-03	96	97	4	PS01359
Domain	PROTEIN_KINASE_TYR	EPHB2 OBSCN SRMS PTK7	1.64e-03	97	97	4	PS00109
Domain	Tyr_kinase_AS	EPHB2 OBSCN SRMS PTK7	1.64e-03	97	97	4	IPR008266
Domain	tRNAsynth_Ia_anticodon-bd	CARS1 CARS2	2.68e-03	15	97	2	IPR009080
Domain	FN3	EPHB2 ROBO4 OBSCN OBSL1 IGDCC3	2.79e-03	185	97	5	SM00060
Domain	Hemopexin_CS	HPX MMP16	3.45e-03	17	97	2	IPR018486
Domain	FN3	EPHB2 ROBO4 OBSCN OBSL1 IGDCC3	3.81e-03	199	97	5	PS50853
Domain	aa-tRNA-synth_I_CS	EPRS1 CARS1	3.87e-03	18	97	2	IPR001412
Domain	IG_LIKE	MPZ ROBO4 OBSCN OBSL1 IGDCC3 PTK7 HMCN2 CD22	4.04e-03	491	97	8	PS50835
Domain	Fd_Rdtase_FAD-bd	NOX1 NOS3	4.31e-03	19	97	2	IPR017927
Domain	FAD_FR	NOX1 NOS3	4.31e-03	19	97	2	PS51384
Domain	Pyr_redox_2	ETFDH MICAL2	4.31e-03	19	97	2	PF07992
Domain	Riboflavin_synthase-like_b-brl	NOX1 NOS3	4.31e-03	19	97	2	IPR017938
Domain	Ig-like_dom	MPZ ROBO4 OBSCN OBSL1 IGDCC3 PTK7 HMCN2 CD22	4.66e-03	503	97	8	IPR007110
Domain	FN3_dom	EPHB2 ROBO4 OBSCN OBSL1 IGDCC3	4.69e-03	209	97	5	IPR003961
Domain	Zinc_finger_PHD-type_CS	KDM5C CHD3 KDM5D	4.70e-03	65	97	3	IPR019786
Pubmed	ADP-ribosylation factor is functionally and physically associated with the Golgi complex.	ARF1 ARF3 ARF4 ARF5	3.48e-10	5	102	4	2105501
Pubmed	Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells.	ARF1 ARF3 ARF4 ARF5	4.84e-09	8	102	4	8195219
Pubmed	Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6).	ARF1 ARF3 ARF4 ARF5	4.84e-09	8	102	4	8947846
Pubmed	Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors.	ARF1 ARF3 ARF4 ARF5	1.44e-08	10	102	4	10828067
Pubmed	Human and Giardia ADP-ribosylation factors (ARFs) complement ARF function in Saccharomyces cerevisiae.	ARF3 ARF4 ARF5	2.45e-08	3	102	3	1447192
Pubmed	ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus.	ARF1 ARF3 ARF4	2.45e-08	3	102	3	23783033
Pubmed	Two distinct populations of ARF bound to Golgi membranes.	ARF3 ARF4 ARF5	9.78e-08	4	102	3	8491770
Pubmed	Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes.	ARF1 ARF3 ARF5	2.44e-07	5	102	3	9038142
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	KDM5C CHD8 CHD3 KDM5D KDM6B EPOP ARID2	4.31e-07	157	102	7	30186101
Pubmed	An Arf/Rab cascade controls the growth and invasiveness of glioblastoma.	ARF1 ARF4 ARF5	4.87e-07	6	102	3	33443570
Pubmed	WLS retrograde transport to the endoplasmic reticulum during Wnt secretion.	ARF3 ARF4 ARF5	4.87e-07	6	102	3	24768165
Pubmed	GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.	ARF1 ARF3 ARF5	8.50e-07	7	102	3	11950392
Pubmed	Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol.	ARF3 ARF4 ARF5	1.36e-06	8	102	3	8355790
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SDSL SPOUT1 OBSCN CHD8 KDM6B ARSG MYORG DIP2A PWWP2B EPOP IL17RE DTX2 HERC1 EVI5L	4.35e-06	1105	102	14	35748872
Pubmed	GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation.	ARF1 ARF3 ARF5	5.29e-06	12	102	3	30631079
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EPRS1 KDM5C CHD8 CHD3 XPO1 ARF3 ARF4 ARID2	6.38e-06	332	102	8	32786267
Pubmed	Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin.	ARF1 ARF3	8.52e-06	2	102	2	1577740
Pubmed	Assignment of human ADP ribosylation factor (ARF) genes ARF1 and ARF3 to chromosomes 1q42 and 12q13, respectively.	ARF1 ARF3	8.52e-06	2	102	2	8661066
Pubmed	Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin.	ARF1 ARF3	8.52e-06	2	102	2	2474826
Pubmed	Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins.	ARF1 ARF4	8.52e-06	2	102	2	1899243
Pubmed	Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling.	NOX1 NOS3	8.52e-06	2	102	2	20639222
Pubmed	CYLD downregulates Livin and synergistically improves gemcitabine chemosensitivity and decreases migratory/invasive potential in bladder cancer: the effect is autophagy-associated.	CYLD BIRC7	8.52e-06	2	102	2	27448305
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	8.52e-06	2	102	2	10441747
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	8.52e-06	2	102	2	16416087
Pubmed	Class II ADP-ribosylation factors are required for efficient secretion of dengue viruses.	ARF4 ARF5	8.52e-06	2	102	2	22105072
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5C KDM5D	8.52e-06	2	102	2	32081420
Pubmed	p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins.	ARF1 HERC1	8.52e-06	2	102	2	8861955
Pubmed	ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway.	ARF1 ARF3	8.52e-06	2	102	2	22971977
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5C KDM5D	8.52e-06	2	102	2	9060413
Pubmed	Myosin 1b functions as an effector of EphB signaling to control cell repulsion.	EPHB2 MYO1B	8.52e-06	2	102	2	26195670
Pubmed	Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: regulation of PTH1R nuclear-cytoplasmic shuttling by importin-alpha/beta and chromosomal region maintenance 1/exportin 1.	XPO1 PTH1R	8.52e-06	2	102	2	17317770
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5C KDM5D	8.52e-06	2	102	2	7524912
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	CLASP1 KDM5C OBSCN XPO1 DIP2A ARID2 HPX TSEN34 HERC1	1.63e-05	497	102	9	36774506
Pubmed	Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments.	ARF4 ARF5	2.55e-05	3	102	2	31201232
Pubmed	Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family.	MYO1A MYO1B	2.55e-05	3	102	2	8449986
Pubmed	GBF1-Arf-COPI-ArfGAP-mediated Golgi-to-ER transport involved in regulation of lipid homeostasis.	ARF4 ARF5	2.55e-05	3	102	2	22185782
Pubmed	Effects of 5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine (BAY 41-2272) on smooth muscle tone, soluble guanylyl cyclase activity, and NADPH oxidase activity/expression in corpus cavernosum from wild-type, neuronal, and endothelial nitric-oxide synthase null mice.	NOX1 NOS3	2.55e-05	3	102	2	17596536
Pubmed	Interaction of calcium-dependent activator protein for secretion 1 (CAPS1) with the class II ADP-ribosylation factor small GTPases is required for dense-core vesicle trafficking in the trans-Golgi network.	ARF4 ARF5	2.55e-05	3	102	2	20921225
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5C KDM5D	2.55e-05	3	102	2	7544442
Pubmed	ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5.	ARF1 ARF5	2.55e-05	3	102	2	22573888
Pubmed	Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism.	OBSCN OBSL1	2.55e-05	3	102	2	31098411
Pubmed	Identification of arfophilin, a target protein for GTP-bound class II ADP-ribosylation factors.	ARF4 ARF5	2.55e-05	3	102	2	10593962
Pubmed	Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis.	ARF1 ARF3	2.55e-05	3	102	2	26330566
Pubmed	[Influence of polymorphism's of endothelial nitric oxide synthase gene and polymorphism of NADPH oxidase gene on development of complications of arterial hypertension].	NOX1 NOS3	2.55e-05	3	102	2	18429753
Pubmed	Myosin I can act as a molecular force sensor.	MYO1A MYO1B	2.55e-05	3	102	2	18599791
Pubmed	Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking.	ARF1 ARF4	2.55e-05	3	102	2	17956946
Pubmed	ADP ribosylation factors 1 and 4 and group VIA phospholipase A₂ regulate morphology and intraorganellar traffic in the endoplasmic reticulum-Golgi intermediate compartment.	ARF1 ARF4	2.55e-05	3	102	2	20881058
Pubmed	Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex.	OBSCN OBSL1	2.55e-05	3	102	2	20133654
Pubmed	Vascular endothelial growth factor receptor-2 activates ADP-ribosylation factor 1 to promote endothelial nitric-oxide synthase activation and nitric oxide release from endothelial cells.	ARF1 NOS3	2.55e-05	3	102	2	20529868
Pubmed	Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target.	NOX1 NOS3	2.55e-05	3	102	2	25317947
Pubmed	Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors.	ARF1 ARF3	2.55e-05	3	102	2	10623590
Pubmed	Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.	OBSCN OBSL1	2.55e-05	3	102	2	27989621
Pubmed	Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin.	OBSCN OBSL1	2.55e-05	3	102	2	20489725
Pubmed	Large-scale concatenation cDNA sequencing.	OBSL1 COX11 ZNF691 ARF1 AJAP1 MICAL2 CHRD HERC1 MMP16	4.62e-05	568	102	9	9110174
Pubmed	A "double adaptor" method for improved shotgun library construction.	OBSL1 COX11 ZNF691 ARF1 AJAP1 MICAL2 CHRD HERC1 MMP16	5.01e-05	574	102	9	8619474
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5C KDM5D	5.09e-05	4	102	2	16541399
Pubmed	The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.	KDM5C KDM5D	5.09e-05	4	102	2	17320160
Pubmed	The arf6 GAP centaurin alpha-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton.	ARF1 ARF5	5.09e-05	4	102	2	15679100
Pubmed	Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation.	ARF1 ARF5	5.09e-05	4	102	2	10589680
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM5C KDM5D	5.09e-05	4	102	2	32732223
Pubmed	Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency.	CHD3 ARID2	5.09e-05	4	102	2	22140357
Pubmed	A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.	KDM5C KDM5D	5.09e-05	4	102	2	7951230
Pubmed	Accelerated atherosclerosis development in C57Bl6 mice by overexpressing AAV-mediated PCSK9 and partial carotid ligation.	NOX1 NOS3	5.09e-05	4	102	2	28504688
Pubmed	Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.	CHD8 ARF1 ARF4 ARF5	5.83e-05	71	102	4	36305789
Pubmed	Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach.	XPO1 ARF3 ARF4 ARF5	6.50e-05	73	102	4	23464991
Pubmed	A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration.	ARF1 ARF5	8.47e-05	5	102	2	10749932
Pubmed	Munc18 interacting proteins: ADP-ribosylation factor-dependent coat proteins that regulate the traffic of beta-Alzheimer's precursor protein.	ARF3 ARF4	8.47e-05	5	102	2	12842896
Pubmed	Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking.	ARF4 ARF5	8.47e-05	5	102	2	22111578
Pubmed	Bone Morphogenic Protein 4 Mediates NOX1-Dependent eNOS Uncoupling, Endothelial Dysfunction, and COX2 Induction in Type 2 Diabetes Mellitus.	NOX1 NOS3	8.47e-05	5	102	2	26121233
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	EPRS1 CMTR1 PIGK ETFDH CHD8 XPO1 ARF3 ARF4 PTK7 NRP2 ARF5 ZBP1 PRKCSH CARS2	8.73e-05	1451	102	14	30550785
Pubmed	DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.	EPHB2 CARS1 BCAT1 CHD3 KYAT1 APOBEC4 MICAL2	1.02e-04	364	102	7	31391242
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CYLD KDM5C OBSL1 CHD8 CHD3 PWWP2B HMCN2 SLC25A43 PRPF4 ARID2 MGA EVI5L	1.07e-04	1116	102	12	31753913
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	OBSCN OBSL1 IGDCC3 PTK7 CD22	1.19e-04	162	102	5	25826454
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	KDM5C KDM5D KDM6B	1.25e-04	33	102	3	26864203
Pubmed	Exploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes.	NRP2 NOS3	1.27e-04	6	102	2	18785001
Pubmed	Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.	XPO1 ARF1 ARF4 ARF5 HERC1 MGA	1.53e-04	271	102	6	25737280
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	EPRS1 TCF20 CHD8 CHD3 XPO1 ARID2 PRKCSH	1.67e-04	394	102	7	27248496
Pubmed	Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.	CHD8 CHD3	1.77e-04	7	102	2	26816381
Pubmed	Association of polymorphisms of angiogenesis genes with breast cancer.	NRP2 NOS3	1.77e-04	7	102	2	17891484
Pubmed	TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis.	PLPPR3 PRKCSH	1.77e-04	7	102	2	22337885
Pubmed	Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.	KDM5C KDM6B	1.77e-04	7	102	2	28262558
Pubmed	Identification of a new Pyk2 target protein with Arf-GAP activity.	ARF1 ARF5	1.77e-04	7	102	2	10022920
Pubmed	Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development.	MPZ ARF1	1.77e-04	7	102	2	23012656
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	EPHB2 TCF20 CLASP1 PIGK CHD8 XPO1 ZNF691 PTK7 ARF5 MICAL2 FAM20B MGA	2.14e-04	1203	102	12	29180619
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	OBSCN CHD8 KIAA1614 ARID2	2.29e-04	101	102	4	10997877
Pubmed	Transcriptional and subcellular regulation of the TRIP-Br family.	XPO1 SERTAD1	2.36e-04	8	102	2	17141982
Pubmed	The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development.	EPHB2 NRP2	2.36e-04	8	102	2	25953347
Pubmed	Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry.	NRP2 SLC17A7	2.36e-04	8	102	2	19620975
Pubmed	The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus.	NRP2 SLC17A7	2.36e-04	8	102	2	22726444
Pubmed	Development of the somatosensory cortex, the cerebellum, and the main olfactory system in Semaphorin 3F knockout mice.	NRP2 SLC17A7	2.36e-04	8	102	2	20006658
Pubmed	A genome-wide association study of the Protein C anticoagulant pathway.	MYH7B DNAJC6	2.36e-04	8	102	2	22216198
Pubmed	Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3.	ARF1 ARF5	2.36e-04	8	102	2	11926829
Pubmed	Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development.	ARF1 ARF3	2.36e-04	8	102	2	38227057
Pubmed	The autism-associated protein CHD8 is required for cerebellar development and motor function.	CHD8 SLC17A7	3.03e-04	9	102	2	33826902
Pubmed	Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation.	WNT3 SLC17A7	3.03e-04	9	102	2	18986540
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	TCF20 OBSL1 CHD8 MGA	3.06e-04	109	102	4	33554859
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	EPRS1 SPOUT1 OBSCN IGDCC3 ARF5 DIP2A TBC1D14 CHRD POTEA	3.22e-04	736	102	9	29676528
Pubmed	Physical map of 17p13 and the genes adjacent to p53.	CHD3 KDM6B	3.77e-04	10	102	2	10662545
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	EPHB2 PTK7 NRP2 SLC17A7	4.01e-04	117	102	4	17145500
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KDM5C KDM5D KDM6B	4.09e-04	49	102	3	34368113
Interaction	DENND1B interactions	XPO1 ARF1 ARF4 ARF5	2.95e-06	21	98	4	int:DENND1B
Interaction	AP4E1 interactions	XPO1 ARF1 ARF3 ARF4 ARF5	6.42e-06	54	98	5	int:AP4E1
Cytoband	9q34.11	SPOUT1 KYAT1 HMCN2	2.30e-04	53	102	3	9q34.11
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	ARF1 ARF3 ARF4 ARF5	4.73e-06	31	66	4	357
GeneFamily	AT-rich interaction domain containing	KDM5C KDM5D ARID2	2.05e-05	15	66	3	418
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ROBO4 OBSCN OBSL1 IGDCC3 PTK7 HMCN2	2.65e-05	161	66	6	593
GeneFamily	Aminoacyl tRNA synthetases, Class I	EPRS1 CARS1 CARS2	4.32e-05	19	66	3	131
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5C KDM5D KDM6B	8.90e-05	24	66	3	485
GeneFamily	Myosins, class I	MYO1A MYO1B	3.62e-04	8	66	2	1097
GeneFamily	Fibronectin type III domain containing	EPHB2 ROBO4 OBSCN IGDCC3	2.78e-03	160	66	4	555
GeneFamily	PHD finger proteins	KDM5C CHD3 KDM5D	4.35e-03	90	66	3	88
ToppCell	LPS_only-Epithelial_alveolar-AT_1-2_Progenitor-AT2_Progenitor\|LPS_only / Treatment groups by lineage, cell group, cell type	SDSL DACT2 OBSL1 BCAT1 ARF3 TGDS SERTAD1	3.86e-07	199	102	7	7b21447bb39cdba37539a12cb475f463010fc23f
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2-AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SDSL DACT2 OBSL1 ARF3 TGDS SERTAD1	6.38e-06	198	102	6	d499dced27b0c0e21acfda2c20fa5c114f605085
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SDSL DACT2 OBSL1 BCAT1 ARF3 TGDS	6.38e-06	198	102	6	aa80315395cb5dffc25927c8a77cd2037aea8772
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DACT2 OBSL1 BCAT1 ARF3 NRP2 TGDS	6.76e-06	200	102	6	e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCell	Striatum-Macroglia-ASTROCYTE-Gja1\|Striatum / BrainAtlas - Mouse McCarroll V32	SDSL ERV3-1 BIRC7 MYORG HPX	8.07e-06	119	102	5	d47880ef1cff036192c43646a04fa8598dd7e1f4
ToppCell	Striatum-Macroglia-ASTROCYTE\|Striatum / BrainAtlas - Mouse McCarroll V32	SDSL ERV3-1 BIRC7 MYORG HPX	8.07e-06	119	102	5	0583387cc4497cf991fa42a81f2f66d9c6b774eb
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	OBSCN NRP2 NOX1 MMP16 NOS3	4.50e-05	170	102	5	af8b56555cbd5a1016ab9ec2ce88225c58c89648
ToppCell	E15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IGDCC3 NRP2 NOX1 MMP16 NOS3	4.63e-05	171	102	5	3112d15f2a28cf4a71992db4971d960716dc1264
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	OBSCN NRP2 NOX1 MMP16 NOS3	4.76e-05	172	102	5	9a1743abcd5fbd38253ea84d88ad716cfb71de36
ToppCell	Control-Myeloid-MoAM2,_CCL18\|Myeloid / Condition, Lineage and Cell class	EPHB2 BCAT1 MYO1B NRP2 HPX	5.45e-05	177	102	5	470f54fe2b21c7350ea471e02039461a3808f700
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM186 MYO1B DNAJC6 PTH1R PTK7	5.45e-05	177	102	5	7c3d46ebd7e8726be6871aa9763e281fc0ec6ac8
ToppCell	droplet-Limb_Muscle-nan-21m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB2 PTH1R AJAP1 EPOP EVI5L	5.45e-05	177	102	5	291231b1520c135e92739e201495fe1935efa927
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NRP2 CLCA2 HPX MMP16 NOS3	5.45e-05	177	102	5	6f6cf93893daac6ae228df36219ee3acf8de8f97
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM186 MYO1B DNAJC6 PTH1R PTK7	5.45e-05	177	102	5	e7b1f3092e6b8d0d580f82648035f5ad12be6961
ToppCell	E17.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	OBSCN IGDCC3 NOX1 MMP16 NOS3	5.60e-05	178	102	5	0139b42494c1186390b12106dea7957e2b6717c2
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CYP8B1 BIRC7 MICAL2 PLIN5 PPP1R16B	5.75e-05	179	102	5	ab3d08b51cd7a37582305615ee221c7a2af83b40
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CYP8B1 BIRC7 MICAL2 PLIN5 PPP1R16B	5.75e-05	179	102	5	35fe9961e228ce255e3317fc244efa35b5adbf8b
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SDSL DACT2 OBSL1 BCAT1 TGDS	6.38e-05	183	102	5	5f2db95d44b7de68779de098892892af540fd431
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(Neuron.Gad1Gad2-Th.Nr4a2)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DNHD1 SDSL NOX1 PLIN5	6.49e-05	94	102	4	c73e99890431750b74f984de5c82e33533ab708b
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(Neuron.Gad1Gad2-Th.Nr4a2)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DNHD1 SDSL NOX1 PLIN5	6.49e-05	94	102	4	1bda61101f45f5c4a68453087b880fdc6d9acfca
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(Neuron.Gad1Gad2-Th.Nr4a2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DNHD1 SDSL NOX1 PLIN5	6.49e-05	94	102	4	9664f74bc0168c92fb8a68cad628323c476f6103
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 NRP2 MICAL2 PLIN5 PPP1R16B	6.72e-05	185	102	5	fb84fcf7f51f53489bcb3962fa9cb483e48257ed
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Tuft\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRHDE OBSL1 MYO1B APOBEC4 PLCG2	6.72e-05	185	102	5	686ed7550c6acd18e71e0076936ec5b07389adbd
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-double_negative_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPZ KDM6B ARF3 ARF5 PPP1R16B	6.89e-05	186	102	5	11929e36d8c9b4c4bc2f5e912f139f474f91ab00
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 NRP2 MICAL2 PLIN5 PPP1R16B	6.89e-05	186	102	5	9d250d5ae7cf9129be05b41d70cb6c3a046c5f1e
ToppCell	COVID_vent-Myeloid-Monocytic-SC_&_Eosinophil\|COVID_vent / Disease condition, Lineage, Cell class and subclass	ROBO4 OBSL1 BCAT1 FREM1 PTK7	7.43e-05	189	102	5	2157a2d40613f7d5ce2e7dbd266df441e449cdaf
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CYP8B1 NRP2 PLIN5 PPP1R16B NOS3	7.43e-05	189	102	5	55a1776a4ce049959b3f13a43744c7314bc1f00a
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT3 KDM5C KDM6B CLCA2 SERTAD1	7.62e-05	190	102	5	3639eb9b887a2d76949cad4a2586524fe0e1015f
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-double_negative_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHD3 KDM6B ARF3 ARF5 PPP1R16B	7.62e-05	190	102	5	84265be128170cbb08d76e824aa108e07da9c3e5
ToppCell	wk_08-11-Endothelial-Lymph_endothelial\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ROBO4 NRP2 MICAL2 PLIN5 PPP1R16B	7.62e-05	190	102	5	d7f1dc032d161529559e01832d1a3112c6f6cc1a
ToppCell	facs-Heart-LA-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 MYO1B NRP2 PPP1R16B NOS3	7.81e-05	191	102	5	a15f0fb4bd7dd77ef5f931b6fc9d68697deec1d1
ToppCell	facs-Heart-LA-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 MYO1B NRP2 PPP1R16B NOS3	7.81e-05	191	102	5	827be47d3574c6c5b021c6f1c1670834344f10cb
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 NRP2 MICAL2 PLIN5 PPP1R16B	8.00e-05	192	102	5	fa0ef05a32c661bdd59b5a9b6f75fd647ee937f3
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 NRP2 MICAL2 PLIN5 PPP1R16B	8.00e-05	192	102	5	4e63d95f75fe6eb3f817e84528883e95093c5bbd
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPRS1 FREM1 NRP2 HMCN2 MMP16	8.20e-05	193	102	5	7cd9671e0ac64f7f3607f564485c63abbb7e7a63
ToppCell	COVID-19-kidney-PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	ROBO4 NRP2 PPP1R16B PLCG2 NOS3	8.61e-05	195	102	5	a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NRP2 METTL24 HMCN2 MICAL2 MMP16	8.82e-05	196	102	5	1522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-B\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ZBP1 CD22 PPP1R16B PLCG2 IGHV4-31	8.82e-05	196	102	5	fc67d8aad1ec4d7f98ffe44fb103e230b9b42c35
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NRP2 METTL24 HMCN2 MICAL2 MMP16	8.82e-05	196	102	5	1c8294014713684b50885e638668f2ce75f357f0
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DACT2 OBSL1 BCAT1 ARF3 TGDS	9.03e-05	197	102	5	1485933986921ff45669d9b7501c8d17050b3e97
ToppCell	AT2_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	BCAT1 MYO1B CHD3 PTK7 MICAL2	9.03e-05	197	102	5	42e49a8ce3118db6c2fd620d70c480b75143c828
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	DACT2 OBSL1 BCAT1 ARF3 TGDS	9.03e-05	197	102	5	1a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCell	LPS_only-Epithelial_alveolar-AT_2\|LPS_only / Treatment groups by lineage, cell group, cell type	DACT2 OBSL1 BCAT1 ARF3 TGDS	9.25e-05	198	102	5	d087e738d69ca9853553fde46d4e7a8906439d32
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ROBO4 CYP8B1 NRP2 PPP1R16B MMP16	9.25e-05	198	102	5	9ab0db78394e730f6866b2db80047149024ad5f6
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DACT2 OBSL1 BCAT1 ARF3 TGDS	9.25e-05	198	102	5	c4e7512f0e1d115f2be8acae6048eda8b6b640b2
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ROBO4 CYP8B1 NRP2 PPP1R16B MMP16	9.25e-05	198	102	5	e47d0e2c6353315c85d7007742bb16b0f05795ed
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-2_Progenitor-AT2_Progenitor\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SDSL DACT2 ARF3 TGDS SERTAD1	9.69e-05	200	102	5	b6cfe5e205ade8bcb75555564f3f57f03f6e40be
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Macroglial-Glia_progenitor_cell\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	BIRC7 ARSG TGDS DTX2 PLCG2	9.69e-05	200	102	5	0b91c8da21ba488109f15c9b927c1dcaf8c6b0ae
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5C KDM5D	6.26e-05	4	96	2	DOID:0060809 (implicated_via_orthology)
Disease	irritable bowel syndrome (implicated_via_orthology)	EPHB2 NOS3	1.04e-04	5	96	2	DOID:9778 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	TCF20 KDM5C CHD8 KDM5D NRP2	1.42e-04	152	96	5	DOID:0060041 (implicated_via_orthology)
Disease	2-hydroxyphenylacetate measurement	SPOUT1 KYAT1	2.90e-04	8	96	2	EFO_0800131
Disease	Macrocephaly	CHD8 CHD3	5.65e-04	11	96	2	C0221355
Disease	Intellectual Disability	TCF20 KDM5C CHD8 CHD3 KDM6B RNASET2 TSEN34	6.54e-04	447	96	7	C3714756
Disease	3-formylindole measurement	SPOUT1 KYAT1	7.98e-04	13	96	2	EFO_0801025
Disease	Mental Retardation, Psychosocial	KDM5C CHD8 KDM6B TSEN34	1.12e-03	139	96	4	C0025363
Disease	Profound Mental Retardation	KDM5C CHD8 KDM6B TSEN34	1.12e-03	139	96	4	C0020796
Disease	Mental deficiency	KDM5C CHD8 KDM6B TSEN34	1.12e-03	139	96	4	C0917816
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C KDM5D	1.22e-03	16	96	2	DOID:0050888 (implicated_via_orthology)
Disease	Tourette syndrome, schizophrenia	TCF20 DNAH10OS	1.55e-03	18	96	2	EFO_0004895, MONDO_0005090
Disease	Paroxysmal atrial fibrillation	WNT3 XPO1 HERC1 NOS3	1.71e-03	156	96	4	C0235480
Disease	familial atrial fibrillation	WNT3 XPO1 HERC1 NOS3	1.71e-03	156	96	4	C3468561
Disease	Persistent atrial fibrillation	WNT3 XPO1 HERC1 NOS3	1.71e-03	156	96	4	C2585653
Disease	Atrial Fibrillation	WNT3 XPO1 HERC1 NOS3	1.88e-03	160	96	4	C0004238
Disease	congenital diaphragmatic hernia (biomarker_via_orthology)	FREM1 NOS3	2.76e-03	24	96	2	DOID:3827 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EPWEPWTQLRLSGHL	TRHDE	131	Q9UKU6
WQAHLARGGRWKESP	EVI5L	536	Q96CN4
RGITIGDWKDNEWPP	ERV3-1	471	Q14264
PKWWEPVRHDGELLR	CHD8	1921	Q9HCK8
EWSSEFGWEKPHIKP	BCAT1	61	P54687
PHSWGIKAHGLRPPW	DNAH10OS	76	P0CZ25
WPRVVLSPISGGIWH	APOBEC4	181	Q8WW27
WDVGGQDKIRPLWRH	ARF5	66	P84085
WPGRPLGSHAWILIA	AJAP1	16	Q9UKB5
SGEWIWESLFHPPRK	ARID2	261	Q68CP9
RGDDPWTEHAKWFPS	BIRC7	136	Q96CA5
WDVGGQDKIRPLWRH	ARF3	66	P61204
TWEGGHRVPALAYWP	ARSG	336	Q96EG1
GLVWPWKSHPIAGIL	DNHD1	646	Q96M86
VARPAWLGPKAWHEC	DNHD1	3976	Q96M86
PKKGPEIQGDWWSHG	C2orf73	71	Q8N5S3
WWSHGKALEPVFLPP	C2orf73	81	Q8N5S3
KFEGHPPESWKWILA	NOX1	261	Q9Y5S8
GKPEPEIEWHWEGRP	OBSL1	271	O75147
WEPWPRLAQHEGGFK	IGDCC3	541	Q8IVU1
SWIRQHPGKGLEWIG	IGHV4-31	56	P0DP07
WWEPSGKAEPHVLGR	MGA	141	Q8IWI9
WPHWNGGDREGVEKV	MYO1A	646	Q9UBC5
PQHSAPGRGVVWEWL	DTX2	101	Q86UW9
LGTWGSWIGPDHDKF	PRKCSH	446	P14314
GVPTPSLRWWKDGVA	HMCN2	1836	Q8NDA2
HWVSALAWPEEGPAT	HERC1	3526	Q15751
LWEGRHVARVGPLPW	IL17RE	526	Q8NFR9
LHWGEPKTWYGVPSL	KDM5D	516	Q9BY66
LWSTLHGDAWGPERK	KDM6B	281	O15054
GHRWSKKAEAELPWG	KIAA1614	656	Q5VZ46
AELGWMVHPPSGWEE	EPHB2	31	P29323
VHTIPWDGKKRVWVP	MYH7B	66	A7E2Y1
HSTWEKGIWHLLPPG	FREM1	1866	Q5H8C1
DWLDIWDGIPHVGPL	NRP2	211	O60462
WDGPDGKPVIYHGWT	PLCG2	361	P16885
IHNVSKEPGGWWKGD	PLCG2	796	P16885
LKDWHPPGGFILGLW	PIGK	361	Q92643
KARGGCPADWAWIVP	NOS3	436	P29474
HFIVWEGAPGARMPW	OBSCN	5901	Q5VST9
PRGWKPSVTHAYWGI	NPY6R	141	Q99463
HGVRVDVKDWDGWEP	PPP1R16B	251	Q96T49
WKPGRVDHTVGWPLD	ETFDH	286	Q16134
VGGEDARPHSWPWQI	CTRC	31	Q99895
SLEWDPAHWPTGRGG	DACT2	531	Q5SW24
KVGTERWWLDGPLVH	GLT6D1	136	Q7Z4J2
RWWLDGPLVHVKSLG	GLT6D1	141	Q7Z4J2
GWAPDGLKHLWAPTG	EPOP	81	A6NHQ4
KILHWRWGEPPVAVP	CHD3	511	Q12873
GWRWIHPGSPTRAAE	COX11	16	Q9Y6N1
IQPDVSGGWDWHAKP	DNAJC6	631	O75061
KLWSIGRWVPLGPAE	C19orf67	281	A6NJJ6
WDVGGQDKIRPLWRH	ARF1	66	P84077
KGWPPLSWLVIDGKH	DIP2A	476	Q14689
PKDLPDWDWRHGCIP	CYLD	841	Q9NQC7
GKIHGFPWWPARVLD	PWWP2B	496	Q6NUJ5
KIRLWHDSRGPSPGW	PKD1L1	1861	Q8TDX9
VTRYEWKPHGAWEEP	CD22	451	P20273
WKPHGAWEEPSLGVL	CD22	456	P20273
GPGEHGQRIEWRKWK	SPOUT1	11	Q5T280
WEWGDGIRVHDSQKP	CMTR1	801	Q8N1G2
WEPPLDKGTVPWLGH	CYP8B1	31	Q9UNU6
RDPHPIWGKDRSWTG	MICAL2	1391	O94851
LGKLHRAAWWGEVPR	POTEA	66	Q6S8J7
KGPRWHIDLQPWAGS	METTL24	106	Q5JXM2
ATWTELPWPHEKVDG	HPX	391	P02790
WGPGRPGWHIECSAI	CARS2	246	Q9HA77
PGWKFNHWELKGVPI	EPRS1	1351	P07814
PWGKGRPGWHIECSA	CARS1	336	P49589
IWTHPGWSPLKTLAG	PRPF4	476	O43172
PELRTHAQAKGWWDG	SCRN2	206	Q96FV2
ATGWKVGWVLGPDHI	KYAT1	251	Q16773
WEAWPRGPGGHSCLV	SH2D5	271	Q6ZV89
PPGLELFRWQWHEVE	SLC9A5	31	Q14940
HGIWSKWAPPLERSR	SLC17A7	191	Q9P2U7
GPWATGHRVWRAEGL	SLC25A43	51	Q8WUT9
SPRQGWEGAKAVAPW	SEBOX	136	Q9HB31
WDKIWPAGGEPDHGT	SRMS	16	Q9H3Y6
KEPLAVDSWWLDPGH	SERTAD1	16	Q9UHV2
WENVPPFDHPLIWKG	SDSL	136	Q96GA7
WWKDGKPLALQPGRH	ROBO4	171	Q8WZ75
WDVGGQDRIRPLWKH	ARF4	66	P18085
TASLWIPGTAKPGHW	CLCA2	561	Q9UQC9
SWRAAGTRWHPVVPP	CHRD	791	Q9H2X0
RLWGWSADGLAKHPP	CLASP1	1126	Q7Z460
DLWWQGIPPSVRGKV	TBC1D14	396	Q9P2M4
SEKIHGLGWRPKVPW	TGDS	306	O95455
RDPPDYWTIHGLWPD	RNASET2	56	O00584
EWPKHWPTFISDIVG	XPO1	141	O14980
GKPWRVDDSEGSWIP	ZNF691	51	Q5VV52
TWGTLVDPWGPQDIH	ZBP1	241	Q9H171
GSGIPPHGIDSAIWW	MMP16	431	P51512
PHGIDSAIWWEDVGK	MMP16	436	P51512
EWDHILCWPLGAPGE	PTH1R	111	Q03431
PVVHLSAGGAPWEWK	PLPPR3	591	Q6T4P5
DHKGELPRGWNWVDV	RWDD4	161	Q6NW29
DWRVQSKDWPHAGRP	TSEN34	201	Q9BSV6
PDVWPLQKHRHPWGR	FAM20B	226	O75063
FRGKAVWERPLHGLW	TMEM186	11	Q96B77
CDSHHKGPPGEGWKW	WNT3	141	P56703
EAILPWGPTDIDHWK	ZBED10P	86	Q96FA7
KSIGSLLENPHWGPW	TCF20	806	Q9UGU0
LLENPHWGPWERKSS	TCF20	811	Q9UGU0
ELVSPHEWEQGAGWP	TEX13A	146	Q9BXU3
GHGAVRSWGPWKVVA	nan	121	Q6ZS52
PGKVHELWGEWGQRP	PLIN5	256	Q00G26
PKGLPEPSVWWEHAG	PTK7	346	Q13308
EPSVWWEHAGVRLPT	PTK7	351	Q13308
LHWGEPKTWYGVPSL	KDM5C	526	P41229
QTWPHWKGPARSGVE	MYO1B	651	O43795
PLWWIAPGDETAHRI	MYORG	636	Q6NSJ0
WVGDPRWKDGSIVIH	MPZ	101	P25189