Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	WD40_repeat_CS	AAAS LLGL1 CDC40 PRPF4 TEP1 WDR17 HIRA	3.55e-06	164	73	7	IPR019775
Domain	-	AAAS LLGL1 CDC40 TECPR2 PRPF4 TEP1 WDR17 HIRA SEMA4C	5.82e-06	333	73	9	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	AAAS LLGL1 CDC40 TECPR2 PRPF4 TEP1 WDR17 HIRA SEMA4C	6.11e-06	335	73	9	IPR015943
Domain	WD40	AAAS LLGL1 CDC40 TECPR2 PRPF4 TEP1 WDR17 HIRA	9.72e-06	268	73	8	SM00320
Domain	WD40_repeat	AAAS LLGL1 CDC40 TECPR2 PRPF4 TEP1 WDR17 HIRA	1.08e-05	272	73	8	IPR001680
Domain	WD_REPEATS_1	AAAS LLGL1 CDC40 TECPR2 PRPF4 TEP1 WDR17 HIRA	1.27e-05	278	73	8	PS00678
Domain	WD_REPEATS_2	AAAS LLGL1 CDC40 TECPR2 PRPF4 TEP1 WDR17 HIRA	1.30e-05	279	73	8	PS50082
Domain	WD_REPEATS_REGION	AAAS LLGL1 CDC40 TECPR2 PRPF4 TEP1 WDR17 HIRA	1.30e-05	279	73	8	PS50294
Domain	WD40_repeat_dom	AAAS LLGL1 CDC40 TECPR2 PRPF4 TEP1 WDR17 HIRA	2.04e-05	297	73	8	IPR017986
Domain	Ald_DH_CS_CYS	ALDH1L2 ALDH9A1 ALDH6A1	3.75e-05	17	73	3	IPR016160
Domain	ALDEHYDE_DEHYDR_GLU	ALDH1L2 ALDH9A1 ALDH6A1	4.48e-05	18	73	3	PS00687
Domain	ALDEHYDE_DEHYDR_CYS	ALDH1L2 ALDH9A1 ALDH6A1	4.48e-05	18	73	3	PS00070
Domain	Ppantetheine_attach_site	FASN ALDH1L2	4.51e-05	3	73	2	IPR006162
Domain	Ald_DH_C	ALDH1L2 ALDH9A1 ALDH6A1	5.31e-05	19	73	3	IPR016163
Domain	Ald_DH_N	ALDH1L2 ALDH9A1 ALDH6A1	5.31e-05	19	73	3	IPR016162
Domain	Ald_DH/histidinol_DH	ALDH1L2 ALDH9A1 ALDH6A1	5.31e-05	19	73	3	IPR016161
Domain	-	ALDH1L2 ALDH9A1 ALDH6A1	5.31e-05	19	73	3	3.40.605.10
Domain	Aldedh	ALDH1L2 ALDH9A1 ALDH6A1	5.31e-05	19	73	3	PF00171
Domain	Aldehyde_DH_dom	ALDH1L2 ALDH9A1 ALDH6A1	5.31e-05	19	73	3	IPR015590
Domain	-	ALDH1L2 ALDH9A1 ALDH6A1	5.31e-05	19	73	3	3.40.309.10
Domain	WD40	AAAS LLGL1 CDC40 PRPF4 TEP1 WDR17 HIRA	6.79e-05	259	73	7	PF00400
Domain	-	FASN ALDH1L2	1.50e-04	5	73	2	1.10.1200.10
Domain	PP-binding	FASN ALDH1L2	1.50e-04	5	73	2	PF00550
Domain	ACP_DOMAIN	FASN ALDH1L2	1.50e-04	5	73	2	PS50075
Domain	PHOSPHOPANTETHEINE	FASN ALDH1L2	1.50e-04	5	73	2	PS00012
Domain	PP-bd_ACP	FASN ALDH1L2	2.24e-04	6	73	2	IPR009081
Domain	Arm	TNPO2 APC KPNA1	2.38e-04	31	73	3	PF00514
Domain	Armadillo	TNPO2 APC KPNA1	8.21e-04	47	73	3	IPR000225
Domain	N2O_reductase_N	AAAS WDR17	1.53e-03	15	73	2	IPR011045
Domain	Ald_DH_CS_GLU	ALDH1L2 ALDH9A1	1.75e-03	16	73	2	IPR029510
Domain	-	MTOR TNPO2 RTTN APC KPNA1	1.77e-03	222	73	5	1.25.10.10
Domain	ARM-type_fold	FOCAD MTOR TNPO2 RTTN APC KPNA1	2.10e-03	339	73	6	IPR016024
Pubmed	The CTRB1-CTRB2 risk allele for chronic pancreatitis discovered in European populations does not contribute to disease risk variation in the Chinese population due to near allele fixation.	CTRB2 CTRB1	4.59e-06	2	75	2	28951524
Pubmed	Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.	CTRB2 CTRB1	4.59e-06	2	75	2	28754779
Pubmed	Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA.	CTRB2 CTRB1	4.59e-06	2	75	2	2917002
Pubmed	Genomic cloning and partial characterization of human chymotrypsinogen gene.	CTRB2 CTRB1	4.59e-06	2	75	2	8186414
Pubmed	The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy.	MTOR DGKZ	4.59e-06	2	75	2	24302719
Pubmed	Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid.	MTOR DGKZ	4.59e-06	2	75	2	15632115
Pubmed	Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer.	FASN APC	4.59e-06	2	75	2	35742953
Pubmed	Regulation of karyopherin α1 and nuclear import by mammalian target of rapamycin.	MTOR KPNA1	4.59e-06	2	75	2	22399302
Pubmed	Chymotrypsin Reduces the Severity of Secretagogue-Induced Pancreatitis in Mice.	CTRB2 CTRB1	4.59e-06	2	75	2	30076839
Pubmed	Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish.	MTOR APC	4.59e-06	2	75	2	24092877
Pubmed	Sequencing of the complex CTRB1-CTRB2 locus in chronic pancreatitis.	CTRB2 CTRB1	4.59e-06	2	75	2	33036922
Pubmed	Evolutionary relationships between laboratory mice and subspecies of Mus musculus based on the restriction fragment length variants of the chymotrypsin gene at the Prt-2 locus.	CTRB2 CTRB1	4.59e-06	2	75	2	2565717
Pubmed	Association of PINX1 but not TEP1 Polymorphisms with Progression to Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B Virus Infection.	PINX1 TEP1	4.59e-06	2	75	2	27221889
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	CEP68 CEP85L MTOR TNPO2 PEX3 MRPS5 ALDH9A1 NEURL4 ATP2B4 KPNA1	5.03e-06	754	75	10	33060197
Pubmed	USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity.	MTOR APC	1.37e-05	3	75	2	31527800
Pubmed	Overexpression of Fatty Acid Synthase Upregulates Glutamine-Fructose-6-Phosphate Transaminase 1 and O-Linked N-Acetylglucosamine Transferase to Increase O-GlcNAc Protein Glycosylation and Promote Colorectal Cancer Growth.	FASN APC	1.37e-05	3	75	2	38732103
Pubmed	Decreased ZMIZ1 suppresses melanogenesis in vitiligo by regulating mTOR/AKT/GSK-3β-mediated glucose uptake.	MTOR ZMIZ1	1.37e-05	3	75	2	38117454
Pubmed	Genetic study of pancreatic proteinase in mice (Mus musculus): linkage of the Prt-2 locus on chromosome 8.	CTRB2 CTRB1	1.37e-05	3	75	2	1016231
Pubmed	Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia.	LLGL1 MTOR	1.37e-05	3	75	2	37587260
Pubmed	Protein kinase C and P2Y12 take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets.	MTOR F2	1.37e-05	3	75	2	24612393
Pubmed	Evolutionary expansion of polyaspartate motif in the activation peptide of mouse cationic trypsinogen limits autoactivation and protects against pancreatitis.	CTRB2 CTRB1	1.37e-05	3	75	2	34643096
Pubmed	Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice.	CTRB2 CTRB1	1.37e-05	3	75	2	32678161
Pubmed	LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription.	BRIP1 REG3A	1.37e-05	3	75	2	31767869
Pubmed	Secretagogue-induced pancreatitis in mice devoid of chymotrypsin.	CTRB2 CTRB1	1.37e-05	3	75	2	38981616
Pubmed	Genetic study of pancreatic proteinase in mice (Mus musculus): genetic variants of trypsin and chymotrypsin.	CTRB2 CTRB1	1.37e-05	3	75	2	1008801
Pubmed	Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems.	ALDH1L2 ALDH9A1 ALDH6A1	1.65e-05	23	75	3	18971422
Pubmed	High-fructose corn syrup enhances intestinal tumor growth in mice.	FASN APC	2.75e-05	4	75	2	30898933
Pubmed	Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma.	MTOR APC	2.75e-05	4	75	2	21062985
Pubmed	Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma.	MTOR APC	2.75e-05	4	75	2	28759045
Pubmed	Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombin.	DGKZ F2	2.75e-05	4	75	2	11309392
Pubmed	Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.	FASN MTOR	2.75e-05	4	75	2	17631500
Pubmed	A tectorin-based matrix and planar cell polarity genes are required for normal collagen-fibril orientation in the developing tectorial membrane.	TECTB OTOG	2.75e-05	4	75	2	28935705
Pubmed	Large-scale concatenation cDNA sequencing.	JTB GLS2 CEP85L ABHD3 APC ZMIZ1 TAPBP KPNA1	3.11e-05	568	75	8	9110174
Pubmed	A "double adaptor" method for improved shotgun library construction.	JTB GLS2 CEP85L ABHD3 APC ZMIZ1 TAPBP KPNA1	3.35e-05	574	75	8	8619474
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MTOR NPEPPS SYNE2 DOCK7 APC DGKZ NEURL4 ATP2B4 HIRA KPNA1	4.11e-05	963	75	10	28671696
Pubmed	Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse.	CTRB2 CTRB1	4.57e-05	5	75	2	6589791
Pubmed	Genetic study of pancreatic proteinase and alpha-amylase in mice (Mus musculus).	CTRB2 CTRB1	4.57e-05	5	75	2	4461036
Pubmed	Obesity promotes PhIP-induced small intestinal carcinogenesis in hCYP1A-db/db mice: involvement of mutations and DNA hypermethylation of Apc.	DOCK7 APC	4.57e-05	5	75	2	27207656
Pubmed	Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1.	CTRB2 CTRB1	4.57e-05	5	75	2	1820020
Pubmed	IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation.	TNPO2 KPNA1	6.84e-05	6	75	2	26060253
Pubmed	Negative regulation of mTOR activation by diacylglycerol kinases.	MTOR DGKZ	6.84e-05	6	75	2	21310925
Pubmed	Genetic mosaic dissection of candidate genes in mice using mosaic analysis with double markers.	LLGL1 APC	6.84e-05	6	75	2	34825212
Pubmed	Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop.	CTRB2 CTRB1	6.84e-05	6	75	2	23814066
Pubmed	Identification of proteins that interact with alpha A-crystallin using a human proteome microarray.	FASN CDC40 ALDH1L2 RAB29	1.27e-04	118	75	4	24453475
Pubmed	mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis.	MTOR APC	1.27e-04	8	75	2	29275959
Pubmed	Mapping of transcription start sites of human retina expressed genes.	WDR17 RS1 CNGA3	1.28e-04	45	75	3	17286855
Pubmed	DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.	CEP68 KBTBD4 DOCK7 CNGA3 HIRA SEMA4C	1.38e-04	364	75	6	31391242
Pubmed	Generation of Mice with Hepatocyte-Specific Conditional Deletion of Notum.	GLS2 APC	1.64e-04	9	75	2	26974334
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	MSRB2 AAAS NPEPPS DGKZ ATP2B4 SEMA4C	1.70e-04	378	75	6	34315543
Pubmed	Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.	SYNE2 GREB1 HIRA	2.33e-04	55	75	3	18570454
Pubmed	Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.	FASN MTOR	2.99e-04	12	75	2	27307439
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	PRPF4 CEP85L NPEPPS DOCK7 APC TUT1 ALDH9A1 NEURL4 KPNA1	3.09e-04	1005	75	9	19615732
Pubmed	Characterization of a novel gene, sperm-tail-associated protein (Stap), in mouse post-meiotic testicular germ cells.	CTRB2 CTRB1	3.52e-04	13	75	2	11468771
Pubmed	Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.	AAAS ALDH1L2 MRPS5 TRMT5 ALDH6A1 NEURL4	3.73e-04	438	75	6	32628020
Pubmed	A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.	LLGL1 MTOR APC	3.82e-04	65	75	3	27453043
Pubmed	The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination.	APC KPNA1	5.40e-04	16	75	2	27213272
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	TECTB OTOG	6.11e-04	17	75	2	20856818
Pubmed	Gene mapping on mouse chromosome 8 by interspecific crosses: new data on a linkage group conserved on human chromosome 16q.	CTRB2 CTRB1	7.66e-04	19	75	2	2571576
Pubmed	Disruption of Nectin-like 1 cell adhesion molecule leads to delayed axonal myelination in the CNS.	CADM3 APC	7.66e-04	19	75	2	19036974
Pubmed	Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14.	CEP68 OTX1	7.66e-04	19	75	2	12174196
Pubmed	Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.	CA11 PINX1	7.66e-04	19	75	2	21060863
Pubmed	A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation.	CTRB2 CTRB1	7.66e-04	19	75	2	16844427
Pubmed	An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies.	GLS2 APC ATP2B4	8.10e-04	84	75	3	15123239
Pubmed	Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.	DOCK7 APC	8.50e-04	20	75	2	32294449
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	MED24 FASN AAAS MTOR SCAMP2 TAPBP ATP2B4 SEMA4C	9.56e-04	942	75	8	31073040
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	FASN MTOR DOCK7 NEURL4	9.73e-04	202	75	4	33005030
Pubmed	Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.	DGKZ F2	1.03e-03	22	75	2	20694011
Pubmed	Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors.	CA11 JTB BRIP1 LLGL1 NPEPPS	1.09e-03	359	75	5	35559673
Pubmed	Rheb1 is required for mTORC1 and myelination in postnatal brain development.	MTOR APC	1.33e-03	25	75	2	21238928
Pubmed	High-resolution mapping of a linkage group on mouse chromosome 8 conserved on human chromosome 16Q.	CTRB2 CTRB1	1.44e-03	26	75	2	9069116
Pubmed	Retinoic acid deficiency impairs the vestibular function.	OTX1 OTOG	1.44e-03	26	75	2	23536097
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	LLGL1 MTOR DOCK7 SCAMP2 ATP2B4 SEMA4C	1.45e-03	569	75	6	30639242
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	MED24 PRPF4 DOCK7 TUT1 KPNA1	1.57e-03	390	75	5	17643375
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	SYNE2 RS1 CNGA3 EPG5	1.64e-03	233	75	4	32290105
Pubmed	SOSTDC1 promotes invasion and liver metastasis in colorectal cancer via interaction with ALCAM/CD166.	MTOR DOCK7	1.67e-03	28	75	2	32801337
Pubmed	Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.	TECTB OTOG	1.67e-03	28	75	2	22808246
Pubmed	Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells.	OTX1 KCNIP3	1.92e-03	30	75	2	25804738
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	MED24 CDC40 DOCK7 HIRA KPNA1	1.95e-03	410	75	5	26949251
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	FOCAD MED24 RNF130 NPEPPS SCAMP2 TUT1 ATP2B4 SEMA4C	2.03e-03	1061	75	8	33845483
Cytoband	Ensembl 112 genes in cytogenetic band chr2q11	MRPS5 KCNIP3 CNGA3 SEMA4C	1.20e-04	153	75	4	chr2q11
Cytoband	16q23.1	CTRB2 CTRB1	1.27e-03	32	75	2	16q23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr11p11	KBTBD4 DGKZ F2	2.06e-03	153	75	3	chr11p11
GeneFamily	WD repeat domain containing	AAAS LLGL1 CDC40 PRPF4 TEP1 WDR17 HIRA	7.27e-06	262	50	7	362
GeneFamily	Aldehyde dehydrogenases	ALDH1L2 ALDH9A1 ALDH6A1	1.87e-05	19	50	3	398
GeneFamily	Armadillo repeat containing\|Importins	TNPO2 KPNA1	1.11e-03	18	50	2	596
Drug	Bio-Phe-CH2Cl	CTRB2 CTRB1 F2	1.82e-06	8	74	3	CID000083924
Drug	Bio-Arg-CH2Cl	CTRB2 CTRB1 F2	1.82e-06	8	74	3	CID000083923
Drug	pyrenebutyl methylphosphonofluoridate	FASN CTRB2 CTRB1	2.73e-06	9	74	3	CID000125653
Drug	FK-401	CTRB2 CTRB1 F2	2.73e-06	9	74	3	CID000135041
Drug	tlmE	CTRB2 CTRB1 F2	2.73e-06	9	74	3	CID000188322
Drug	resorufin acetate	CTRB2 ALDH9A1 CTRB1	3.89e-06	10	74	3	CID003080579
Drug	phenyl 4-guanidinobenzoate	CTRB2 CTRB1 F2	9.21e-06	13	74	3	CID003015798
Drug	Pd-Ti	CTRB2 CTRB1 TG	9.21e-06	13	74	3	CID006452040
Drug	Lga-afc	GLS2 CTRB2 CTRB1	9.21e-06	13	74	3	CID003081120
Drug	BOCPheONP	CTRB2 CTRB1	1.04e-05	2	74	2	CID000111308
Drug	MPM-06	CTRB2 CTRB1	1.04e-05	2	74	2	CID000161546
Drug	NSC-374899	CTRB2 CTRB1	1.04e-05	2	74	2	CID000435726
Drug	methylbenzenebutanoate	CTRB2 CTRB1	1.04e-05	2	74	2	CID000281254
Drug	Asp-Arg-Val-Tyr-Val-His-Pro-Phe-His-Leu	CTRB2 CTRB1	1.04e-05	2	74	2	CID004418081
Drug	c189	CTRB2 CTRB1	1.04e-05	2	74	2	CID000248048
Drug	dansyl-D-arginine methyl ester	CTRB2 CTRB1	1.04e-05	2	74	2	CID000191369
Drug	methyl 6-phenylhexanoate	CTRB2 CTRB1	1.04e-05	2	74	2	CID011820300
Drug	L-NAPAMP	F2 TAPBP	1.04e-05	2	74	2	CID003083488
Drug	5-aminotetrazole	CTRB2 CTRB1	1.04e-05	2	74	2	CID000020467
Drug	2-bromoisobutyric acid	CTRB2 CTRB1	1.04e-05	2	74	2	CID000074924
Drug	p-toluamidine	CTRB2 CTRB1	1.04e-05	2	74	2	CID000122753
Drug	N-acetyl-alpha-azaphenylalanine phenyl ester	CTRB2 CTRB1	1.04e-05	2	74	2	CID000191275
Drug	isobutyl sulfide	CTRB2 CTRB1	1.04e-05	2	74	2	CID000011607
Drug	ONO-3307	CTRB2 CTRB1 F2	1.46e-05	15	74	3	CID000127139
Drug	ogen	APC CTRB2 CTRB1 F2	1.51e-05	46	74	4	CID000023703
Drug	Harmine hydrochloride [343-27-1]; Down 200; 16uM; MCF7; HT_HG-U133A	PEX3 ABHD3 DSCC1 ATP2B4 HIRA SEMA4C	2.92e-05	183	74	6	2750_DN
Drug	N-acetylbenzotriazole	CTRB2 CTRB1	3.12e-05	3	74	2	CID000087784
Drug	photophor	CTRB2 CTRB1	3.12e-05	3	74	2	CID000014780
Drug	dibutyl iodomethaneboronate	CTRB2 CTRB1	3.12e-05	3	74	2	CID000098591
Drug	zinc;dipicolinate	CTRB2 CTRB1	3.12e-05	3	74	2	CID004309911
Drug	2-oxobut-3-ynoate	CTRB2 CTRB1	3.12e-05	3	74	2	CID000171547
Drug	AFMeq	CTRB2 CTRB1	3.12e-05	3	74	2	CID000194069
Drug	Bz-Cti-otbu	CTRB2 CTRB1	3.12e-05	3	74	2	CID006452691
Drug	n-(2-oxoethyl)benzamide	CTRB2 CTRB1	3.12e-05	3	74	2	CID000188995
Drug	AC1L49DM	CTRB2 CTRB1	3.12e-05	3	74	2	CID000152933
Drug	c140	CTRB2 CTRB1	3.12e-05	3	74	2	CID002783250
Drug	Benzamidomethaneboronic acid	CTRB2 CTRB1	3.12e-05	3	74	2	CID000127677
Drug	phenyl hippurate	CTRB2 CTRB1	3.12e-05	3	74	2	CID000076323
Drug	FK-386	CTRB2 CTRB1	3.12e-05	3	74	2	CID000135044
Drug	FK-375	CTRB2 CTRB1	3.12e-05	3	74	2	CID000135042
Drug	carbostyril-124	CTRB2 CTRB1	3.12e-05	3	74	2	CID000088277
Drug	N-trifluoroacetyl-4-fluorophenylalanine	CTRB2 CTRB1	3.12e-05	3	74	2	CID000328214
Drug	C18 4	CTRB2 CTRB1	3.12e-05	3	74	2	CID000077248
Drug	taraxastane	CTRB2 CTRB1	3.12e-05	3	74	2	CID006429404
Drug	Phe-phe-ome	CTRB2 CTRB1	3.12e-05	3	74	2	CID000151728
Drug	phenylethaneboronic acid	CTRB2 CTRB1	3.12e-05	3	74	2	CID000065389
Drug	3-amino-2-pyridone	CTRB2 CTRB1	3.12e-05	3	74	2	CID000322353
Drug	ASA-BMPA	CTRB2 CTRB1	3.12e-05	3	74	2	CID003035649
Drug	p-nitrophenyl benzoate	CTRB2 CTRB1	3.12e-05	3	74	2	CID000070396
Drug	Z-Phe-OMe	CTRB2 CTRB1	3.12e-05	3	74	2	CID003082435
Drug	3-methylcoumarin	CTRB2 CTRB1	3.12e-05	3	74	2	CID000017130
Drug	2-propyl methylphosphonochloridate	CTRB2 CTRB1	3.12e-05	3	74	2	CID000102124
Drug	FK-316	CTRB2 CTRB1	3.12e-05	3	74	2	CID000133688
Drug	AC1L19T8	CTRB2 CTRB1	3.12e-05	3	74	2	CID000000694
Drug	Marinostatin D	CTRB2 CTRB1	3.12e-05	3	74	2	CID000132206
Drug	1FD7	CTRB2 CTRB1	3.12e-05	3	74	2	CID000445579
Drug	Glt-leu-phe-nh-meq	CTRB2 CTRB1	3.12e-05	3	74	2	CID000194914
Drug	AC1L4Z4F	CTRB2 CTRB1	3.12e-05	3	74	2	CID000194913
Drug	Glt-Phe-NH-FMeq	CTRB2 CTRB1	3.12e-05	3	74	2	CID000194912
Drug	diacetyl trimer	CTRB2 CTRB1	3.12e-05	3	74	2	CID000193527
Drug	FK-448	CTRB2 CTRB1	3.12e-05	3	74	2	CID006917869
Drug	Ac-Phe-OMe	CTRB2 CTRB1	3.12e-05	3	74	2	CID000097805
Drug	thiobenzyl N-heptafluorobutyrylanthranilate	CTRB2 CTRB1	3.12e-05	3	74	2	CID000133906
Drug	Triprolidine hydrochloride [550-70-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A	MTOR TNPO2 APC ATP2B4 HIRA KPNA1	3.94e-05	193	74	6	7008_DN
Drug	geldanamycin; Down 200; 1uM; MCF7; HT_HG-U133A	CEP68 TWSG1 DSCC1 RAB29 HIRA SEMA4C	3.94e-05	193	74	6	6946_DN
Drug	Piromidic acid [19562-30-2]; Down 200; 13.8uM; MCF7; HT_HG-U133A	GLS2 APC TEP1 RAB29 ALDH6A1 HIRA	4.17e-05	195	74	6	4398_DN
Drug	Meprylcaine hydrochloride [956-03-6]; Down 200; 14.8uM; MCF7; HT_HG-U133A	CEP68 AAAS APC TUT1 MOCS1 HIRA	4.42e-05	197	74	6	3544_DN
Drug	fludrocortisone acetate; Up 200; 1uM; MCF7; HG-U133A	CA11 LLGL1 KBTBD4 TNPO2 KPNA1 TG	4.42e-05	197	74	6	281_UP
Drug	azathioprine, USP; Down 200; 100uM; MCF7; HG-U133A	CA11 CADM3 ZIC4 LLGL1 KBTBD4 TECPR2	4.81e-05	200	74	6	338_DN
Drug	Benzoyl-dl-leucine	CTRB2 CTRB1	6.23e-05	4	74	2	CID000294887
Drug	Acafcek	CTRB2 CTRB1	6.23e-05	4	74	2	CID000197677
Drug	B-1,3-od	CTRB2 CTRB1	6.23e-05	4	74	2	CID011971053
Drug	dehydromerodesmosine	CTRB2 CTRB1	6.23e-05	4	74	2	CID006443540
Drug	alpha-amyrin palmitate	CTRB2 CTRB1	6.23e-05	4	74	2	CID000185477
Drug	poly-THIQ	CTRB2 CTRB1	6.23e-05	4	74	2	CID006453487
Drug	N-(4-carboxycyclohexylmethyl)-maleimide	CTRB2 CTRB1	6.23e-05	4	74	2	CID011548799
Drug	G2505_sigma	CTRB2 CTRB1	6.23e-05	4	74	2	CID000111098
Drug	p-fluorobenzenesulfonyl chloride	CTRB2 CTRB1	6.23e-05	4	74	2	CID000009588
Drug	gallium phosphide	GLS2 REG3A	6.23e-05	4	74	2	CID000082901
Drug	BSSDA	CTRB2 CTRB1	6.23e-05	4	74	2	CID003081106
Drug	AC1L2HV6	CTRB2 CTRB1	6.23e-05	4	74	2	CID000047328
Drug	AC1L4X1Z	CTRB2 CTRB1	6.23e-05	4	74	2	CID000193815
Drug	NSC-676827	CTRB2 CTRB1	6.23e-05	4	74	2	CID000385555
Drug	6-amino-1,2-benzopyrone	CTRB2 CTRB1	6.23e-05	4	74	2	CID000046152
Drug	nitrophenylethanol	CTRB2 CTRB1	6.23e-05	4	74	2	CID000097851
Drug	Ac-Trp-OEt	CTRB2 CTRB1	1.04e-04	5	74	2	CID000304749
Drug	apne	CTRB2 CTRB1	1.04e-04	5	74	2	CID000098192
Drug	7-chloro-4-nitrobenzofuran	CTRB2 CTRB1	1.04e-04	5	74	2	CID000130782
Drug	Z-Phe-Leu	CTRB2 CTRB1	1.04e-04	5	74	2	CID000333351
Drug	5'-FSBAzA	CTRB2 CTRB1	1.04e-04	5	74	2	CID000130430
Drug	AC1L3F57	CTRB2 CTRB1	1.04e-04	5	74	2	CID000139565
Drug	3,5-dimethylpyrazole-1-carboxamidine	CTRB2 CTRB1	1.04e-04	5	74	2	CID000097525
Drug	Maap-borov	CTRB2 CTRB1	1.04e-04	5	74	2	CID005486914
Drug	2-amino-4,6-dichlorotriazine	CTRB2 CTRB1	1.04e-04	5	74	2	CID000013615
Drug	AC1O52A0	CTRB2 CTRB1	1.04e-04	5	74	2	CID006475891
Drug	allysine aldol	CTRB2 CTRB1	1.04e-04	5	74	2	CID000191270
Drug	C37H40N2O6	RNF130 APC TWSG1	1.13e-04	29	74	3	CID000010170
Drug	AC1L3JHX	LLGL1 MTOR CTRB2 TWSG1 CTRB1	1.14e-04	146	74	5	CID000090206
Drug	octyl isocyanate	CTRB2 CTRB1	1.55e-04	6	74	2	CID000076616
Drug	N-benzoyltyrosine butylamide	CTRB2 CTRB1	1.55e-04	6	74	2	CID000125261
Disease	level of chymotrypsinogen B2 in blood serum	CTRB2 CTRB1	6.20e-06	2	74	2	OBA_2041192
Disease	chymotrypsinogen B measurement	CTRB2 CTRB1	1.86e-05	3	74	2	EFO_0801477
Disease	prothrombin measurement	DGKZ F2	3.71e-05	4	74	2	EFO_0020692
Disease	retinitis pigmentosa (implicated_via_orthology)	EYS PRPF4 EPG5	4.24e-05	27	74	3	DOID:10584 (implicated_via_orthology)
Disease	trypsin-2 measurement	CTRB2 CTRB1	3.36e-04	11	74	2	EFO_0008305
Disease	end stage renal disease (implicated_via_orthology)	MTOR F2	1.14e-03	20	74	2	DOID:783 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	FASN BRIP1 LLGL1 CEP85L MTOR SYNE2 ZMIZ1 KCNIP3 EPG5	1.44e-03	1074	74	9	C0006142
Disease	ankylosing spondylitis	FASN NPEPPS ZMIZ1	1.57e-03	91	74	3	EFO_0003898
Disease	systemic mastocytosis	EYS MOCS1	1.79e-03	25	74	2	MONDO_0016586
Disease	gamma-glutamyltyrosine measurement	BRIP1 ZMIZ1	2.09e-03	27	74	2	EFO_0021144
Disease	glutamate measurement	BRIP1 OTOG	2.41e-03	29	74	2	EFO_0010487

Protein segments in the cluster

Peptide	Gene	Start	Entry
FLTWLPESLSCNKAL	TWSG1	16	Q9GZX9
AALPLLSNAECKKSW	CTRB2	176	Q6GPI1
SAEQLLSPECWKATL	EPG5	1841	Q9HCE0
WKPLSASVLAVACQS	AAAS	201	Q9NRG9
QIASWKSAPALACGN	ALDH9A1	161	P49189
SCLSQWKSVLSPGSA	CEP68	176	Q76N32
LAWKSAACLAAGNTL	ALDH1L2	601	Q3SY69
TFACSESLEKPLNWL	ABHD3	251	Q8WU67
NAAWSLCAVGKRQSP	CA11	56	O75493
NCQSSGSKPAARLTW	CADM3	151	Q8N126
SLETLALTNNPWKCT	CHAD	291	O15335
GKPFSCTSLSLSQWL	ATP2B4	1016	P23634
LLLANKCDLSPWAVS	RAB29	121	O14966
ALLTCSLWPARADNA	RNF130	16	Q86XS8
FTDFLCLPAKSSANW	NIBAN3	631	Q86XR2
CLPAKSSANWILAAS	NIBAN3	636	Q86XR2
TCSAHVASVPAKLWA	LLGL1	396	Q15334
CKRAFPAWADTSVLS	ALDH6A1	86	Q02252
ISNTCLLPQNSSWKA	C22orf46	156	C9J442
DPALAQIAKAWASNC	GLIPR1	61	P48060
LLFWKRGICPNSSSA	EYS	301	Q5T1H1
LPWLASLAASSCNDS	GREB1	501	Q4ZG55
SSSWINKDGSKPLLC	PEX3	221	P56589
LRGPCWDQSSKASAQ	PINX1	261	Q96BK5
QSPFDAALCSAWKQR	GDPGP1	56	Q6ZNW5
LAKSNPDLWGVSLCT	GLS2	186	Q9UI32
LLIDPKNSCSSSRQW	NPEPPSL1	331	A6NEC2
DANSKCLSPGSWASA	MOCS1	456	Q9NZB8
AASSAWKLNFNSPDC	OTX1	326	P32242
KPTLVCSSALGSWSN	PCDHA1	736	Q9Y5I3
LLCSALAWQQSLSGK	BRIP1	56	Q9BX63
SESWSFGKVPLNTCL	DSCC1	216	Q9BVC3
TPRGSWACSIFDLKN	DOCK7	186	Q96N67
AKSTTSAWACPLILR	GGT6	391	Q6P531
WSSLSKLTAPDNCGQ	CEP85L	156	Q5SZL2
ELPSSLCGWNKISSL	BPESC1	71	Q9GZL8
LSPKWCFLDATTASR	DGKZ	711	Q13574
CFNPSLSTWNLVSDK	HIRA	846	P54198
DSSRPVWLKAINCAT	FASN	1436	P49327
CLVKWILSSTAPQGS	KCNIP3	46	Q9Y2W7
LLIDPKNSCSSSRQW	NPEPPS	331	P55786
AALPLLSNAECKKSW	CTRB1	176	P17538
LNFPASACALKRAAW	NEURL4	1201	Q96JN8
STWNALSPKLSCDTR	FOCAD	646	Q5VW36
LFGNSWKTLSACSPL	OTOG	676	Q6ZRI0
LLKDSSSPSLRSCWA	MTOR	1291	P42345
APWASLGLSAKTCNN	GPR132	21	Q9UNW8
SICSKIWKSAQASPL	RTTN	596	Q86VV8
QCSLNTLPAASILAW	MRPS5	26	P82675
LSPKSWTDADLACQK	REG3A	56	Q06141
LSAFKWLLDGQPCSS	TRMT5	396	Q32P41
WLKSAERTAACPNSS	SYNE2	6151	Q8WXH0
LASCAADGSVKLWSL	PRPF4	296	O43172
NAVWALSNLCRGKSP	KPNA1	231	P52294
SSAPSLWKIASCNGS	KBTBD4	461	Q9NVX7
AVTLSPNGKWLACQS	CDC40	466	O60508
GTALAKLAVWCALSS	MED24	806	O75448
NLLACLAWFSGNSSK	SCAMP2	166	O15127
RFKVVLNSCWATPSA	TECTB	196	Q96PL2
SAAASVQCLAWVPSA	WDR17	266	Q8IZU2
TTFLKARLACSAPNW	SEMA4C	276	Q9C0C4
KSVLSALWNLSAHCT	APC	586	P25054
WLKLPSIGAASCTAQ	CLEC20A	111	Q6ZU45
RSAWPLAKCNTNTSN	CNGA3	131	Q16281
ASSDGILWNLAKCSP	TEP1	2481	Q99973
SLATCELPLAKSEWQ	MSRB2	41	Q9Y3D2
KGASLPSSASWRCAL	TUT1	756	Q9H6E5
ASAKWASGLTPAQNC	TAPBP	101	O15533
ALSDWNLRKCSAAAL	TNPO2	366	O14787
APTKEGSFLWLCQSS	TECPR2	1131	O15040
KWLAADGTATPSLCS	ZIC4	131	Q8N9L1
SQAAWRTLLTALCFP	nan	26	Q5W150
GLPCLAWASAQAKAL	F2	231	P00734
PNALWSAGATSLDCI	RS1	46	O15537
LLSSPSVLLCNVKDW	TG	1751	P01266
LSSPWALTKQDSACF	ZNF891	6	A8MT65
DKFTPKSAALLSSWC	ZMIZ1	86	Q9ULJ6
EEKLSASTSNLPCWL	JTB	36	O76095
PDRWASLVTAACAKA	MYO7B	1366	Q6PIF6