Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	KLF16 ZNF311 STOX2 ZNF28 ZNF530 ZNF425 ZNF837 ZNF316 ZNF611 ZNF816 ZNF696 ZNF888 ZNF701 ZNF543 ZNF418 ZNF583 CASZ1 ZNF697	2.64e-07	1459	62	18	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	KLF16 ZNF311 ZNF28 ZNF530 ZNF425 ZNF837 ZNF316 ZNF611 ZNF816 ZNF696 ZNF888 ZNF701 ZNF543 ZNF418 ZNF583 CASZ1 ZNF697	8.76e-07	1412	62	17	GO:0000981
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1B CACNB2 CACNA1I	1.01e-05	14	62	3	GO:0008331
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	KLF16 ZNF311 ZNF28 ZNF530 ZNF837 ZNF316 ZNF611 ZNF816 ZNF888 ZNF701 ZNF543 ZNF418 ZNF583 ZNF697	2.13e-05	1244	62	14	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	KLF16 ZNF311 ZNF28 ZNF530 ZNF837 ZNF316 ZNF611 ZNF816 ZNF888 ZNF701 ZNF543 ZNF418 ZNF583 ZNF697	2.71e-05	1271	62	14	GO:0000987
GeneOntologyMolecularFunction	sodium:bicarbonate symporter activity	SLC4A7 SLC4A10	1.41e-04	6	62	2	GO:0008510
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1B CACNB2	3.37e-04	9	62	2	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1B CACNB2	3.37e-04	9	62	2	GO:0099626
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1B CACNB2 CACNA1I	3.93e-04	46	62	3	GO:0005245
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1B CACNB2 SLC4A7 PKD1 SCN9A SLC4A10 CACNA1I	5.78e-04	465	62	7	GO:0046873
GeneOntologyMolecularFunction	calcium channel activity	CACNA1B CACNB2 PKD1 CACNA1I	6.94e-04	129	62	4	GO:0005262
GeneOntologyMolecularFunction	monoatomic cation:bicarbonate symporter activity	SLC4A7 SLC4A10	7.24e-04	13	62	2	GO:0140410
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1B CACNB2 PKD1 CACNA1I	1.25e-03	151	62	4	GO:0015085
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC4A7 SCN9A SLC4A10 CACNA1I	1.97e-03	171	62	4	GO:0015081
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN9A CACNA1I	2.94e-03	26	62	2	GO:0005248
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	CACNA1B CACNB2 SLC4A7 PKD1 SCN9A SLC4A10 CACNA1I	3.21e-03	627	62	7	GO:0022890
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1B CACNB2 PKD1 SCN9A CACNA1I	4.22e-03	343	62	5	GO:0005261
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	CACNA1B CACNB2 SLC4A7 PKD1 SCN9A SLC4A10 CACNA1I	4.39e-03	664	62	7	GO:0008324
GeneOntologyMolecularFunction	bicarbonate transmembrane transporter activity	SLC4A7 SLC4A10	4.43e-03	32	62	2	GO:0015106
GeneOntologyMolecularFunction	solute:inorganic anion antiporter activity	SLC4A7 SLC4A10	4.43e-03	32	62	2	GO:0005452
GeneOntologyCellularComponent	calcium channel complex	CACNA1B CACNB2 PKD1 CACNA1I	5.76e-05	73	60	4	GO:0034704
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1B CACNB2 CACNA1I	3.13e-04	46	60	3	GO:0005891
GeneOntologyCellularComponent	transcription elongation factor complex	ELOA CDK12 CCNL1	5.59e-04	56	60	3	GO:0008023
GeneOntologyCellularComponent	cation channel complex	CACNA1B CACNB2 PKD1 SCN9A CACNA1I	5.68e-04	235	60	5	GO:0034703
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN9A CACNA1I	1.07e-03	17	60	2	GO:0001518
GeneOntologyCellularComponent	photoreceptor ribbon synapse	CACNB2 RIMS2	1.20e-03	18	60	2	GO:0098684
GeneOntologyCellularComponent	nuclear protein-containing complex	SNIP1 ELOA SNRNP48 AKAP17A CDK12 DROSHA CCNL1 MEPCE FIP1L1 CHD8 PRPF38A	1.68e-03	1377	60	11	GO:0140513
Domain	zf-C2H2	KLF16 ZNF311 PRDM9 ZNF28 ZNF530 ZNF425 ZNF837 ZNF316 ZNF611 ZNF816 ZNF696 ZNF701 ZNF543 ZNF418 ZNF583 CASZ1 ZNF697	3.44e-11	693	60	17	PF00096
Domain	ZINC_FINGER_C2H2_2	KLF16 ZNF311 PRDM9 ZNF28 ZNF530 ZNF425 ZNF837 ZNF316 ZNF611 ZNF816 ZNF696 ZNF701 ZNF543 ZNF418 ZNF583 CASZ1 ZNF697	1.95e-10	775	60	17	PS50157
Domain	ZINC_FINGER_C2H2_1	KLF16 ZNF311 PRDM9 ZNF28 ZNF530 ZNF425 ZNF837 ZNF316 ZNF611 ZNF816 ZNF696 ZNF701 ZNF543 ZNF418 ZNF583 CASZ1 ZNF697	2.03e-10	777	60	17	PS00028
Domain	-	KLF16 ZNF311 PRDM9 ZNF28 ZNF530 ZNF425 ZNF837 ZNF316 ZNF611 ZNF816 ZNF696 ZNF701 ZNF543 ZNF418 ZNF583 ZNF697	2.63e-10	679	60	16	3.30.160.60
Domain	Znf_C2H2-like	KLF16 ZNF311 PRDM9 ZNF28 ZNF530 ZNF425 ZNF837 ZNF316 ZNF611 ZNF816 ZNF696 ZNF701 ZNF543 ZNF418 ZNF583 CASZ1 ZNF697	2.95e-10	796	60	17	IPR015880
Domain	Znf_C2H2	KLF16 ZNF311 PRDM9 ZNF28 ZNF530 ZNF425 ZNF837 ZNF316 ZNF611 ZNF816 ZNF696 ZNF701 ZNF543 ZNF418 ZNF583 CASZ1 ZNF697	3.51e-10	805	60	17	IPR007087
Domain	Znf_C2H2/integrase_DNA-bd	KLF16 ZNF311 PRDM9 ZNF28 ZNF530 ZNF425 ZNF837 ZNF316 ZNF611 ZNF816 ZNF696 ZNF701 ZNF543 ZNF418 ZNF583 ZNF697	3.62e-10	694	60	16	IPR013087
Domain	ZnF_C2H2	KLF16 ZNF311 PRDM9 ZNF28 ZNF530 ZNF425 ZNF837 ZNF316 ZNF611 ZNF816 ZNF696 ZNF701 ZNF543 ZNF418 ZNF583 CASZ1 ZNF697	3.71e-10	808	60	17	SM00355
Domain	KRAB	ZNF311 PRDM9 ZNF28 ZNF530 ZNF425 ZNF316 ZNF611 ZNF816 ZNF701 ZNF543 ZNF418 ZNF583	1.25e-09	358	60	12	PF01352
Domain	KRAB	ZNF311 PRDM9 ZNF28 ZNF530 ZNF425 ZNF316 ZNF611 ZNF816 ZNF701 ZNF543 ZNF418 ZNF583	1.77e-09	369	60	12	SM00349
Domain	KRAB	ZNF311 PRDM9 ZNF28 ZNF530 ZNF425 ZNF316 ZNF611 ZNF816 ZNF701 ZNF543 ZNF418 ZNF583	1.82e-09	370	60	12	IPR001909
Domain	KRAB	ZNF311 ZNF28 ZNF530 ZNF425 ZNF316 ZNF611 ZNF816 ZNF701 ZNF543 ZNF418 ZNF583	1.63e-08	358	60	11	PS50805
Domain	zf-C2H2_6	ZNF311 PRDM9 ZNF530 ZNF425 ZNF316 ZNF611 ZNF816 ZNF701 ZNF543 ZNF418	5.60e-08	314	60	10	PF13912
Domain	Anion_exchange	SLC4A7 SLC4A10	1.01e-04	5	60	2	IPR001717
Domain	ANION_EXCHANGER_2	SLC4A7 SLC4A10	2.11e-04	7	60	2	PS00220
Domain	ANION_EXCHANGER_1	SLC4A7 SLC4A10	2.11e-04	7	60	2	PS00219
Domain	Band3_cytoplasmic_dom	SLC4A7 SLC4A10	3.60e-04	9	60	2	IPR013769
Domain	Band_3_cyto	SLC4A7 SLC4A10	3.60e-04	9	60	2	PF07565
Domain	-	SLC4A7 SLC4A10	3.60e-04	9	60	2	3.40.1100.10
Domain	PTrfase/Anion_transptr	SLC4A7 SLC4A10	4.49e-04	10	60	2	IPR016152
Domain	VDCCAlpha1	CACNA1B CACNA1I	4.49e-04	10	60	2	IPR002077
Domain	HCO3_cotransp	SLC4A7 SLC4A10	4.49e-04	10	60	2	PF00955
Domain	HCO3_transpt_euk	SLC4A7 SLC4A10	4.49e-04	10	60	2	IPR003020
Domain	HCO3_transpt_C	SLC4A7 SLC4A10	4.49e-04	10	60	2	IPR011531
Domain	Krueppel-associated_box-rel	PRDM9 ZNF425	7.74e-04	13	60	2	IPR003655
Domain	Channel_four-helix_dom	CACNA1B SCN9A CACNA1I	8.15e-04	57	60	3	IPR027359
Domain	-	CACNA1B SCN9A CACNA1I	8.15e-04	57	60	3	1.20.120.350
Domain	Chromo_domain	CHD8 CHD1	2.68e-03	24	60	2	IPR023780
Domain	Chromo	CHD8 CHD1	3.14e-03	26	60	2	PF00385
Domain	CHROMO_2	CHD8 CHD1	3.64e-03	28	60	2	PS50013
Domain	CHROMO_1	CHD8 CHD1	3.64e-03	28	60	2	PS00598
Domain	SNF2_N	CHD8 CHD1	4.73e-03	32	60	2	PF00176
Domain	SNF2_N	CHD8 CHD1	4.73e-03	32	60	2	IPR000330
Domain	Chromodomain-like	CHD8 CHD1	4.73e-03	32	60	2	IPR016197
Domain	CHROMO	CHD8 CHD1	5.03e-03	33	60	2	SM00298
Domain	Chromo/shadow_dom	CHD8 CHD1	5.03e-03	33	60	2	IPR000953
Domain	DNA/RNA_helicase_DEAH_CS	CHD8 CHD1	5.64e-03	35	60	2	IPR002464
Domain	Ion_trans_dom	CACNA1B SCN9A CACNA1I	5.89e-03	114	60	3	IPR005821
Domain	Ion_trans	CACNA1B SCN9A CACNA1I	5.89e-03	114	60	3	PF00520
Domain	DEAH_ATP_HELICASE	CHD8 CHD1	6.62e-03	38	60	2	PS00690
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ELOA ZNF311 ZNF28 ZNF530 CDK12 ZNF425 ZNF611 ZNF696 FIP1L1 ZNF701 ZNF543 ZNF418 ZNF583 ZNF697	3.76e-05	1387	43	14	M734
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1B CACNB2 CACNA1I	5.80e-05	25	43	3	M47948
Pathway	REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS_BY_KRAB_ZFP_PROTEINS	ZNF28 ZNF425 ZNF816 ZNF418	3.08e-04	107	43	4	M48260
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A7 SLC4A10	4.03e-04	10	43	2	M27335
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A7 SLC4A10	4.03e-04	10	43	2	MM15073
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1B CACNB2	4.91e-04	11	43	2	MM14498
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1B CACNB2	4.91e-04	11	43	2	M26913
Pathway	REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS	ZNF28 ZNF425 ZNF816 ZNF418	8.98e-04	142	43	4	M48257
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SNIP1 SNRNP48 AKAP17A CDK12 ZC3H13 FIP1L1 CHD8 PRPF38A NCOA5	6.69e-10	251	62	9	31076518
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	SNIP1 ELOA ZNF28 SLC4A7 USP42 CDK12 CCNL1 ZNF316 MEPCE ZNF696 CHD8 CHD1 CASZ1 ZNF697	2.01e-08	1203	62	14	29180619
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF311 ZNF316 ZNF611 ZNF701 ZNF543 ZNF583 ZNF697	3.56e-08	181	62	7	37372979
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	USP36 SNIP1 SLC4A7 AKAP17A CDK12 DROSHA CCNL1 ELAPOR1 ANKRD11 CHD8 CHD1 PRPF38A CASZ1	1.91e-06	1497	62	13	31527615
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CEP350 STOX2 VPS13D SLC4A7 MEPCE ANKRD11 FIP1L1 PLEKHA5 CBARP FAM117B	2.76e-06	861	62	10	36931259
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	VANGL2 ELOA SNRNP48 AKAP17A USP42 CDK12 DROSHA ZC3H13 FIP1L1 PRPF38A NCOA5	2.99e-06	1082	62	11	38697112
Pubmed	The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis.	SNIP1 DROSHA	3.13e-06	2	62	2	18632581
Pubmed	Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain.	SLC4A7 SLC4A10	3.13e-06	2	62	2	17928512
Pubmed	Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma.	VANGL2 PRICKLE1	3.13e-06	2	62	2	27036398
Pubmed	Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.	CEP350 VPS13D TMCC2 OTUD3	3.14e-06	56	62	4	9455484
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	USP36 SNIP1 CDK12 ZC3H13 FIP1L1 PLEKHA5 PRPF38A	3.69e-06	361	62	7	26167880
Pubmed	Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis.	VANGL2 PRICKLE1 PKD1	8.11e-06	22	62	3	27582005
Pubmed	The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8.	USP36 DROSHA	9.37e-06	3	62	2	36950067
Pubmed	NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.	SCN9A SLC4A10 PLEKHA5	1.53e-05	27	62	3	23359859
Pubmed	A SCL4A10 gene product maps selectively to the basolateral plasma membrane of choroid plexus epithelial cells.	SLC4A7 SLC4A10	1.87e-05	4	62	2	14592810
Pubmed	Immunocytochemical identification of electroneutral Na⁺-coupled HCO₃⁻ transporters in freshly dissociated mouse medullary raphé neurons.	SLC4A7 SLC4A10	3.12e-05	5	62	2	23500099
Pubmed	Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium.	VANGL2 PKD1	3.12e-05	5	62	2	26245976
Pubmed	Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.	CACNA1B CACNB2	3.12e-05	5	62	2	16787652
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	VANGL2 USP36 STOX2 CDK12 PLEKHA5 CHD8 RIMS2	4.32e-05	529	62	7	14621295
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1B CACNB2 CACNA1I	4.35e-05	38	62	3	30786075
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	USP36 ELOA CDK12 ZC3H13 ATAD2B ANKRD11 FIP1L1 CHD8 CHD1	4.67e-05	954	62	9	36373674
Pubmed	Analysis of PRICKLE1 in human cleft palate and mouse development demonstrates rare and common variants involved in human malformations.	VANGL2 PRICKLE1	4.67e-05	6	62	2	24689077
Pubmed	Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice.	SLC4A7 SLC4A10	4.67e-05	6	62	2	31001720
Pubmed	Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis.	CACNA1B CACNB2	4.67e-05	6	62	2	8756350
Pubmed	beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain.	CACNA1B CACNB2	4.67e-05	6	62	2	10328888
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	ZNF28 PRICKLE1 ZC3H13 PKD1 ZNF316 CHD8 CHD1 FAM117B RIMS2 NCOA5	5.38e-05	1215	62	10	15146197
Pubmed	Rebuilding essential active zone functions within a synapse.	CACNA1B RIMS2	6.53e-05	7	62	2	35176221
Pubmed	Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear.	VANGL2 PRICKLE1	6.53e-05	7	62	2	17376975
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1B CACNA1I	8.69e-05	8	62	2	28330839
Pubmed	Mouse histamine N-methyltransferase: cDNA cloning, expression, gene cloning and chromosomal localization.	CACNA1B CACNB2	8.69e-05	8	62	2	11475331
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	USP36 SNIP1 KLF16 USP42 ZC3H13 ANKRD11 FIP1L1 PRPF38A CASZ1 NCOA5	9.07e-05	1294	62	10	30804502
Pubmed	A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.	CACNA1B CACNB2	1.12e-04	9	62	2	28130356
Pubmed	Prickle1 stunts limb growth through alteration of cell polarity and gene expression.	VANGL2 PRICKLE1	1.12e-04	9	62	2	23913870
Pubmed	Expression of planar cell polarity genes during development of the mouse CNS.	VANGL2 PRICKLE1	1.12e-04	9	62	2	16487141
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1B CACNA1I	1.12e-04	9	62	2	16382099
Pubmed	Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes.	VANGL2 PRICKLE1	1.12e-04	9	62	2	20534871
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	SLC4A7 AKAP17A CDK12 CCNL1 ANKRD11	1.20e-04	269	62	5	29511261
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	VANGL2 USP36 SNIP1 AKAP17A DROSHA ZNF316 MEPCE FIP1L1 CHD8	1.54e-04	1116	62	9	31753913
Pubmed	Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a.	VANGL2 PRICKLE1	1.70e-04	11	62	2	25190059
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	USP36 CDK12 CCNL1 PLEKHA5 CHD8 CHD1	1.96e-04	472	62	6	38943005
Pubmed	A high-density association screen of 155 ion transport genes for involvement with common migraine.	CACNB2 SCN9A	2.04e-04	12	62	2	18676988
Pubmed	Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene).	SLC4A7 SLC4A10	2.04e-04	12	62	2	21705333
Pubmed	Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity.	VANGL2 PRICKLE1	2.04e-04	12	62	2	19706528
Pubmed	Microtubules enable the planar cell polarity of airway cilia.	VANGL2 PRICKLE1	2.04e-04	12	62	2	23122850
Pubmed	The protein interaction landscape of the human CMGC kinase group.	CEP350 CDK12 DROSHA MEPCE FIP1L1 FAM117B PRPF38A	2.34e-04	695	62	7	23602568
Pubmed	Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.	VANGL2 PRICKLE1	2.41e-04	13	62	2	21246654
Pubmed	Blood pressure and hypertension are associated with 7 loci in the Japanese population.	CACNB2 CASZ1	2.41e-04	13	62	2	20479155
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CEP350 VPS13D TMCC2 ELAPOR1 CASZ1 NCOA5	2.47e-04	493	62	6	15368895
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	VPS13D KIF19 SCN9A MEPCE ANKRD11 PLEKHA5	2.58e-04	497	62	6	36774506
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	SNIP1 ELOA CDK12 ZC3H13 MEPCE FIP1L1 PRPF38A	2.73e-04	713	62	7	29802200
Pubmed	Deficiency of the planar cell polarity protein Vangl2 in podocytes affects glomerular morphogenesis and increases susceptibility to injury.	VANGL2 PRICKLE1	2.81e-04	14	62	2	25145929
Pubmed	Genetic mapping of the mouse genes encoding the voltage-sensitive calcium channel subunits.	CACNA1B CACNB2	2.81e-04	14	62	2	7490102
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	AKAP17A MEPCE FIP1L1 ZNF701	3.19e-04	182	62	4	32239614
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	CEP350 ELOA SLC4A7 CDK12 FIP1L1 PLEKHA5 CHD1	3.23e-04	733	62	7	34672954
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1B CACNB2	3.23e-04	15	62	2	20188150
Pubmed	Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects.	VANGL2 PRICKLE1	3.23e-04	15	62	2	26883626
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1B CACNB2	3.23e-04	15	62	2	24453333
Pubmed	The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate.	VANGL2 PRICKLE1	3.23e-04	15	62	2	29636380
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	USP36 USP42 CDK12 CCNL1	3.47e-04	186	62	4	33637726
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	USP36 ELOA KLF16 USP42 MEPCE FIP1L1 CHD1 NCOA5	3.61e-04	989	62	8	36424410
Pubmed	The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled.	VANGL2 PRICKLE1	3.69e-04	16	62	2	22771245
Pubmed	Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance.	VANGL2 PRICKLE1	4.18e-04	17	62	2	21316586
Pubmed	A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.	VANGL2 PRICKLE1	4.18e-04	17	62	2	28292423
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ELOA USP42 CDK12 ZC3H13 CCNL1 FIP1L1 PRPF38A	4.47e-04	774	62	7	15302935
Pubmed	A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.	CACNA1B CACNB2 RIMS2	4.80e-04	85	62	3	23055939
Pubmed	Genome-wide association study of blood pressure and hypertension.	CACNB2 CASZ1	5.24e-04	19	62	2	19430479
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	AKAP17A DROSHA ZC3H13 MEPCE FIP1L1 PRPF38A NCOA5	5.73e-04	807	62	7	22681889
Pubmed	Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo.	VANGL2 PRICKLE1	6.42e-04	21	62	2	18701545
Pubmed	T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration.	VANGL2 PRICKLE1	6.42e-04	21	62	2	17119020
Pubmed	Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.	SLC4A7 CASZ1	6.42e-04	21	62	2	25249183
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	CEP350 SNIP1 ELOA KLF16 AKAP17A CDK12 DROSHA FIP1L1 PRPF38A	6.92e-04	1371	62	9	36244648
Pubmed	USP39 is essential for mammalian epithelial morphogenesis through upregulation of planar cell polarity components.	VANGL2 PRICKLE1	7.06e-04	22	62	2	35440748
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CDK12 TMCC2 PLEKHA5 CHD8	7.09e-04	225	62	4	12168954
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ELOA ATAD2B CCNL1 CHD8 CHD1 CASZ1	7.47e-04	608	62	6	36089195
Pubmed	Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.	USP36 USP42	7.72e-04	23	62	2	14715245
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	VANGL2 ZC3H13 CHD8	7.94e-04	101	62	3	26949739
Pubmed	Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis.	VANGL2 PRICKLE1	8.41e-04	24	62	2	22333836
Pubmed	The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.	AKAP17A CDK12 CCNL1	8.64e-04	104	62	3	31365120
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	VANGL2 CACNB2 SLC4A7 PLEKHA5 CBARP	9.32e-04	421	62	5	36976175
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	MEPCE CHD1 PRPF38A NCOA5	1.06e-03	251	62	4	28077445
Pubmed	Conditionals by inversion provide a universal method for the generation of conditional alleles.	DROSHA SCN9A	1.07e-03	27	62	2	23918385
Pubmed	Genetic mapping of eight SH3 domain genes on seven mouse chromosomes.	CACNA1B CACNB2	1.15e-03	28	62	2	10087302
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	USP36 SNIP1 FIP1L1 PRPF38A	1.19e-03	259	62	4	30404004
Pubmed	Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.	CACNB2 SLC4A7	1.23e-03	29	62	2	21909115
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	VANGL2 STOX2 FIP1L1 PLEKHA5	1.26e-03	263	62	4	34702444
Pubmed	Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling.	VANGL2 PRICKLE1	1.32e-03	30	62	2	20630950
Pubmed	Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis.	VANGL2 PRICKLE1	1.50e-03	32	62	2	23177622
Pubmed	OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.	USP42 OTUD3	1.50e-03	32	62	2	33669244
Pubmed	A human MAP kinase interactome.	CEP350 SYNPO2 PLEKHA5 CHD8 ZNF418	1.76e-03	486	62	5	20936779
Interaction	IFI27L1 interactions	USP36 SNIP1 ELOA CDK12 ZC3H13 PRPF38A NCOA5	1.11e-09	65	62	7	int:IFI27L1
Interaction	LINC02910 interactions	USP36 SNIP1 ELOA CDK12 ZC3H13 PRPF38A NCOA5	1.65e-08	95	62	7	int:LINC02910
Interaction	DHX8 interactions	USP36 SNIP1 ELOA AKAP17A CDK12 ZC3H13 FIP1L1 CHD1 PRPF38A CASZ1	1.93e-08	292	62	10	int:DHX8
Interaction	DHX40 interactions	USP36 ELOA DROSHA ZC3H13 MEPCE ANKRD11 FIP1L1 CHD1 NCOA5	6.66e-08	249	62	9	int:DHX40
Interaction	ANAPC15 interactions	USP36 SNIP1 ELOA CDK12 ZC3H13 PRPF38A NCOA5	1.30e-07	128	62	7	int:ANAPC15
Interaction	DVL3 interactions	VANGL2 SNIP1 AKAP17A PRICKLE1 CCNL1 ZNF837 ZNF696 PRPF38A ZNF697	1.81e-07	280	62	9	int:DVL3
Interaction	SAA1 interactions	USP36 SNIP1 CDK12 ZC3H13 PRPF38A	6.58e-07	54	62	5	int:SAA1
Interaction	RAD18 interactions	SNIP1 ELOA SNRNP48 AKAP17A CDK12 ZC3H13 FIP1L1 CHD1 PRPF38A NCOA5	1.22e-06	457	62	10	int:RAD18
Interaction	H2AJ interactions	USP36 SNIP1 ELOA CDK12 MEPCE PRPF38A	2.56e-06	127	62	6	int:H2AJ
Interaction	SNRNP40 interactions	USP36 SNIP1 AKAP17A USP42 CDK12 ZC3H13 ATAD2B ZNF316 MEPCE CHD1 NCOA5	3.39e-06	637	62	11	int:SNRNP40
Interaction	YWHAG interactions	CEP350 SNIP1 STOX2 SYNPO2 VPS13D SLC4A7 AKAP17A CDK12 ZC3H13 MEPCE ANKRD11 FIP1L1 PLEKHA5 CBARP FAM117B	4.09e-06	1248	62	15	int:YWHAG
Interaction	PSENEN interactions	USP36 SNIP1 ELOA ZC3H13 PRPF38A	5.01e-06	81	62	5	int:PSENEN
Interaction	TRIM28 interactions	USP36 ELOA ZNF311 ZNF28 CDK12 ZNF316 MEPCE ZNF611 ZNF816 ZNF888 ZNF701 PRPF38A ZNF543 ZNF418 ZNF583 ZNF697	6.73e-06	1474	62	16	int:TRIM28
Interaction	NKTR interactions	SNIP1 ZNF311 ZNF816 ZNF543 ZNF418	8.41e-06	90	62	5	int:NKTR
Interaction	PEA15 interactions	SNIP1 ELOA ZC3H13 ANKRD11 PRPF38A	8.41e-06	90	62	5	int:PEA15
Interaction	EZH1 interactions	SNIP1 ELOA CDK12 ZC3H13 PRPF38A	9.36e-06	92	62	5	int:EZH1
Interaction	DDX23 interactions	USP36 ELOA AKAP17A CDK12 ZC3H13 MEPCE ANKRD11 FIP1L1 CHD1	1.51e-05	480	62	9	int:DDX23
Interaction	RNF4 interactions	SNIP1 ELOA ZNF28 SLC4A7 AKAP17A USP42 CDK12 CCNL1 ZNF316 MEPCE ZNF696 CHD8 CHD1 CASZ1 ZNF697	1.81e-05	1412	62	15	int:RNF4
Interaction	UQCR11 interactions	SNIP1 CDK12 ZC3H13 PRPF38A	2.12e-05	53	62	4	int:UQCR11
Interaction	IFI6 interactions	SNIP1 CDK12 ZC3H13 PRPF38A	2.29e-05	54	62	4	int:IFI6
Interaction	CLK2 interactions	SNIP1 ZNF837 MEPCE FIP1L1 PRPF38A NCOA5	2.98e-05	195	62	6	int:CLK2
Interaction	CACNA1D interactions	CACNA1B CACNB2 SCN9A	5.36e-05	24	62	3	int:CACNA1D
Interaction	CACNB1 interactions	CACNA1B CACNB2 CBARP	6.08e-05	25	62	3	int:CACNB1
Interaction	ZCCHC10 interactions	VANGL2 SNIP1 AKAP17A USP42 CDK12 PRPF38A	8.60e-05	236	62	6	int:ZCCHC10
Interaction	CACNB3 interactions	CACNA1B CACNB2 CBARP	1.29e-04	32	62	3	int:CACNB3
Interaction	PRPF38A interactions	SNIP1 CCNL1 MEPCE FIP1L1 PRPF38A	1.37e-04	161	62	5	int:PRPF38A
Interaction	KRTAP10-6 interactions	SNIP1 ZNF696 ZNF543 ZNF418	1.56e-04	88	62	4	int:KRTAP10-6
Interaction	GAGE2E interactions	USP36 ZC3H13 PRPF38A	1.84e-04	36	62	3	int:GAGE2E
Interaction	SRRM4 interactions	SNIP1 AKAP17A PRPF38A	2.00e-04	37	62	3	int:SRRM4
Interaction	CACNA1B interactions	CACNA1B CACNB2 SCN9A	2.00e-04	37	62	3	int:CACNA1B
Interaction	TMEM14B interactions	SNIP1 ELOA CDK12 ZC3H13 PRPF38A NCOA5	2.14e-04	279	62	6	int:TMEM14B
Interaction	PPP1R10 interactions	SNIP1 ELOA MEPCE FIP1L1 PRPF38A	2.25e-04	179	62	5	int:PPP1R10
Interaction	TMSB4Y interactions	ZC3H13 PRPF38A NCOA5	2.34e-04	39	62	3	int:TMSB4Y
Interaction	KRTAP10-7 interactions	ZNF425 ZNF837 ZNF696 ZNF543 ZNF418 ZNF697	2.79e-04	293	62	6	int:KRTAP10-7
Interaction	MFAP1 interactions	SNIP1 KLF16 CCNL1 MEPCE FIP1L1 PRPF38A	2.89e-04	295	62	6	int:MFAP1
Interaction	SRSF4 interactions	SNIP1 AKAP17A USP42 CDK12 MEPCE PRPF38A	3.16e-04	300	62	6	int:SRSF4
Interaction	RNPS1 interactions	SNIP1 AKAP17A USP42 CDK12 CCNL1 FIP1L1 PRPF38A	3.20e-04	425	62	7	int:RNPS1
Interaction	SRPK2 interactions	USP36 SNIP1 AKAP17A CDK12 DROSHA ZC3H13 FIP1L1 PLEKHA5 PRPF38A	3.26e-04	717	62	9	int:SRPK2
Interaction	GPALPP1 interactions	SNIP1 ZNF311 ZNF816	3.36e-04	44	62	3	int:GPALPP1
Interaction	BRD2 interactions	VANGL2 SNIP1 KLF16 AKAP17A MEPCE CHD8 CYP4F12	3.38e-04	429	62	7	int:BRD2
Interaction	C1orf35 interactions	SNIP1 AKAP17A CCNL1 MEPCE FIP1L1 PRPF38A	3.39e-04	304	62	6	int:C1orf35
Interaction	ANKRD50 interactions	SNIP1 CDK12 ZC3H13 PRPF38A	3.43e-04	108	62	4	int:ANKRD50
Interaction	TPX2 interactions	SNIP1 KLF16 CDK12 PRPF38A NCOA5	4.10e-04	204	62	5	int:TPX2
Interaction	MECP2 interactions	VANGL2 ELOA SNRNP48 AKAP17A USP42 CDK12 DROSHA ZC3H13 MEPCE FIP1L1 PRPF38A NCOA5	4.80e-04	1287	62	12	int:MECP2
Interaction	YWHAH interactions	CEP350 STOX2 VPS13D SLC4A7 ZC3H13 MEPCE ANKRD11 PLEKHA5 CBARP FAM117B RIMS2	4.84e-04	1102	62	11	int:YWHAH
Interaction	GAGE5 interactions	SNIP1 ELOA ZC3H13	5.50e-04	52	62	3	int:GAGE5
Interaction	CENPB interactions	ZNF311 ZNF816 ZNF543 ZNF418	5.78e-04	124	62	4	int:CENPB
Interaction	NUP43 interactions	USP36 CDK12 ZC3H13 ATAD2B ZNF316 ANKRD11 CHD8 CHD1	6.32e-04	625	62	8	int:NUP43
Interaction	JPH3 interactions	SNIP1 PRPF38A NCOA5	6.49e-04	55	62	3	int:JPH3
Interaction	AIF1 interactions	USP36 SNIP1	7.11e-04	13	62	2	int:AIF1
Cytoband	19q13.41	ZNF28 ZNF611 ZNF816 ZNF888 ZNF701	8.09e-08	78	63	5	19q13.41
Cytoband	19q13.43	ZNF530 ZNF837 ZNF543 ZNF418 ZNF583	1.40e-07	87	63	5	19q13.43
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF28 ZNF530 ZNF837 ZNF611 ZNF816 ZNF888 ZNF701 ZNF543 ZNF418 ZNF583	4.92e-06	1192	63	10	chr19q13
Cytoband	1p36.22	VPS13D CASZ1	1.20e-03	37	63	2	1p36.22
Cytoband	7p22.1	USP42 ZNF316	1.93e-03	47	63	2	7p22.1
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	KLF16 ZNF311 PRDM9 ZNF28 ZNF530 ZNF425 ZNF837 ZNF316 ZNF611 ZNF816 ZNF696 ZNF888 ZNF701 ZNF543 ZNF418 ZNF583 CASZ1 ZNF697	7.08e-15	718	42	18	28
GeneFamily	Calcium voltage-gated channel subunits	CACNA1B CACNB2 CACNA1I	2.92e-05	26	42	3	253
GeneFamily	Ubiquitin specific peptidases	USP36 USP42	7.49e-03	56	42	2	366
Coexpression	ZHONG_PFC_C3_ASTROCYTE	CACNA1B STOX2 SLC4A7 ATAD2B PKD1 ZNF316 SCN9A ZNF611	3.25e-06	389	61	8	M39102
Coexpression	GSE22935_24H_VS_48H_MBOVIS_BCG_STIM_MYD88_KO_MACROPHAGE_UP	PRDM9 ATAD2B CCNL1 FIP1L1 PRPF38A NCOA5	6.97e-06	199	61	6	M7756
Coexpression	FAN_EMBRYONIC_CTX_EX_4_EXCITATORY_NEURON	CACNA1B PKD1 SCN9A SLC4A10 CACNA1I	4.28e-05	166	61	5	M39026
Coexpression	HE_LIM_SUN_FETAL_LUNG_C1_GHRL_POS_NE_PRECURSOR_CELL	KLF16 CACNB2 KIF19 PKD1 ELAPOR1 RIMS2 CASZ1	6.10e-05	429	61	7	M45694
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	VANGL2 CACNA1B ELAPOR1 SLC4A10 RIMS2	3.92e-06	167	63	5	c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B PKD1 SLC4A10 PLEKHA5 RIMS2	8.54e-06	196	63	5	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B PKD1 SLC4A10 PLEKHA5 RIMS2	8.97e-06	198	63	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	CEP350 VPS13D ZC3H13 ANKRD11 CHD1	8.97e-06	198	63	5	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	CACNA1B PKD1 SLC4A10 PLEKHA5 RIMS2	9.41e-06	200	63	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CEP350 ATAD2B CCNL1 ANKRD11 CHD1	9.41e-06	200	63	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF28 ATAD2B ZNF611 ZNF583	5.32e-05	145	63	4	e808502fa52baf1c400f3c9b918a167127e78af9
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D122\|Adult / Lineage, Cell type, age group and donor	CACNB2 SYNPO2 TMCC2 CBARP	7.42e-05	158	63	4	410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-7\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	CACNA1B ENTPD3 SCN9A FAM117B	8.57e-05	164	63	4	81c41e1b5535b7969bcf6fa2456f828e8e8e2ff7
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|390C / Donor, Lineage, Cell class and subclass (all cells)	USP36 SLC4A7 ZNF611 ZNF583	9.63e-05	169	63	4	cfc9ff103d13a2d5eacc457e800f53fdd29f7738
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIF19 ELAPOR1 CYP4F12 RIMS2	1.08e-04	174	63	4	3503c7dec498597f76a86dbd5e4bb2311e743bde
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-9\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CACNB2 ZNF888 ZNF543 PGBD2	1.15e-04	177	63	4	ae55773c531099a9e94f44f01ba48b5e71dddc53
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	VANGL2 ZNF530 ZNF316 NCOA5	1.23e-04	180	63	4	c3d1521ac90f2e3fc31158e6e61907e05c37af39
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	CEP350 CDK12 CCNL1 CHD8	1.31e-04	183	63	4	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 CCNL1 ANKRD11 CHD1	1.34e-04	184	63	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	343B-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ZNF28 FAM117B ZNF418 NCOA5	1.36e-04	185	63	4	02cbf492bc40abebaa93a3a208888afae72fbe06
ToppCell	343B-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ZNF28 FAM117B ZNF418 NCOA5	1.36e-04	185	63	4	1b8e3ddb91797f84e4b15d2457b0c008e5be50db
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRICKLE1 TMCC2 PLEKHA5 OTUD3	1.39e-04	186	63	4	60830822d3de3147816693404fd03392e04c2b8e
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRICKLE1 TMCC2 PLEKHA5 OTUD3	1.39e-04	186	63	4	37860daeecd6d412bd3797f30496a56da667fbd1
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRICKLE1 TMCC2 PLEKHA5 OTUD3	1.39e-04	186	63	4	baebeffdd426ce767190ddefc857cc78e6a58d36
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	CEP350 VPS13D CDK12 ZC3H13	1.39e-04	186	63	4	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	droplet-Bladder-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDK12 CCNL1 ANKRD11 CHD1	1.42e-04	187	63	4	663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell	PCW_10-12-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KIF19 ELAPOR1 SLC4A10 RIMS2	1.42e-04	187	63	4	98477ba04a42a8da80a72f41a182429f46283595
ToppCell	droplet-Tongue-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDK12 CCNL1 ANKRD11 CHD1	1.45e-04	188	63	4	d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCell	RA-14._Fibroblast_III\|RA / Chamber and Cluster_Paper	USP36 SLC4A7 CCNL1 CHD1	1.48e-04	189	63	4	46e9a58aacd79db5a02898a8c7244e1884adcfd1
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	CACNB2 SYNPO2 PLEKHA5 CASZ1	1.48e-04	189	63	4	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	RA-14._Fibroblast_III\|World / Chamber and Cluster_Paper	USP36 SLC4A7 CCNL1 CHD1	1.48e-04	189	63	4	b6e12d24d2b0735730bdc625f8318c1c9c2a9b3b
ToppCell	facs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRICKLE1 TMCC2 CASZ1 ZNF697	1.51e-04	190	63	4	52213cd2a6a20772d4f49ba9ac0407abafa528db
ToppCell	Globus_pallidus-Neuronal\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CACNA1B ELAPOR1 SLC4A10 CBARP	1.51e-04	190	63	4	416de85d8841dac883faa6f5339b2fb461a09e82
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	CACNB2 SYNPO2 PLEKHA5 CASZ1	1.51e-04	190	63	4	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CACNA1B ELAPOR1 SLC4A10 RIMS2	1.51e-04	190	63	4	b5c6f3248c0c2f648e1578457c6a729ca22bf0da
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KIF19 SCN9A ELAPOR1 RIMS2	1.64e-04	194	63	4	b30379f8dc41c86c746af9930541fbb4819d8fa0
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SYNPO2 SLC4A10 PLEKHA5 RIMS2	1.67e-04	195	63	4	2e1df01bf6e4e98e6cd9fb50926e34c5077b8666
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	CEP350 ZC3H13 CCNL1 RIMS2	1.74e-04	197	63	4	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B SLC4A10 PLEKHA5 RIMS2	1.77e-04	198	63	4	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B SLC4A10 PLEKHA5 RIMS2	1.77e-04	198	63	4	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B SLC4A10 PLEKHA5 RIMS2	1.77e-04	198	63	4	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B SLC4A10 PLEKHA5 RIMS2	1.77e-04	198	63	4	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SLC4A7 ATAD2B CCNL1 ANKRD11	1.80e-04	199	63	4	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	CEP350 VPS13D ZC3H13 ANKRD11	1.80e-04	199	63	4	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	Transverse-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	KLF16 ZNF530 SCN9A ZNF697	1.80e-04	199	63	4	fd75dccb37d96448edf72b7d042b06833d4ead24
ToppCell	lymphoid-NK_cell-NK_cell\|NK_cell / Lineage, cell class and subclass	USP36 ANKRD11 CHD1 CASZ1	1.80e-04	199	63	4	945fbf5845403a8b22d04963f50ad69c414b6153
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CACNA1B ENTPD3 SLC4A10 CACNA1I	1.84e-04	200	63	4	2f481e2fd248c02a5aa2e0248c16808df142fed2
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CACNA1B ENTPD3 SLC4A10 CACNA1I	1.84e-04	200	63	4	dc674124475edf83908b51a4e1454bc2dc4f06fa
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CACNA1B ENTPD3 SLC4A10 CACNA1I	1.84e-04	200	63	4	bd4b9f6b37f4a3c960c4149cf0cfd2caf3327d2d
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Intermediate\|6m / Sample Type, Dataset, Time_group, and Cell type.	SYNPO2 ZC3H13 CCNL1 SCN9A	1.84e-04	200	63	4	7c261e39ac30b318511373ab7302aa53b8b81b9c
Drug	mibefradil	CACNA1B CACNB2 PKD1 SCN9A CACNA1I	8.56e-07	64	62	5	CID000060662
Drug	CNS 1145	CACNA1B CACNB2 PKD1 CACNA1I	1.92e-06	33	62	4	CID000190902
Drug	IHC-64	CACNA1B CACNB2 PKD1 CACNA1I	1.92e-06	33	62	4	CID000162753
Drug	isradipine	CACNA1B CACNB2 PKD1 SCN9A CACNA1I	7.84e-06	100	62	5	CID000003784
Drug	Verapamil	CACNA1B CACNB2 CACNA1I	1.05e-05	16	62	3	DB00661
Drug	lamotrigine	CACNA1B CACNB2 PKD1 SCN9A CACNA1I	1.62e-05	116	62	5	CID000003878
Drug	Cinildipine	CACNA1B CACNB2 PKD1 CACNA1I	1.65e-05	56	62	4	CID000002752
Drug	rapamycin; Up 200; 0.1uM; HL60; HG-U133A	VPS13D ZC3H13 TMCC2 ELAPOR1 CACNA1I RIMS2	1.69e-05	199	62	6	362_UP
Drug	nilvadipine	CACNA1B CACNB2 PKD1 CACNA1I	2.17e-05	60	62	4	CID000004494
Drug	IAA-94	CACNA1B CACNB2 PKD1 CACNA1I	2.32e-05	61	62	4	CID000003667
Drug	bepridil	CACNA1B CACNB2 PKD1 SCN9A CACNA1I	2.41e-05	126	62	5	CID000002351
Drug	lercanidipine	CACNA1B CACNB2 PKD1 CACNA1I	2.63e-05	63	62	4	CID000065866
Drug	gallopamil	CACNA1B CACNB2 PKD1 CACNA1I	3.36e-05	67	62	4	CID000001234
Drug	lanthanum	CACNA1B CACNB2 ENTPD3 PKD1 CACNA1I	3.48e-05	136	62	5	CID000023926
Drug	AC1L2AC7	CACNA1B CACNB2 PKD1 CACNA1I	3.77e-05	69	62	4	CID000068733
Drug	isovalerate	CACNA1B CACNB2 PKD1 CACNA1I NCOA5	4.42e-05	143	62	5	CID000010430
Drug	CAS 298-57-7	CACNA1B CACNB2 PKD1 CACNA1I	4.71e-05	73	62	4	CID000002761
Drug	ethosuximide	CACNA1B CACNB2 PKD1 CACNA1I	4.97e-05	74	62	4	CID000003291
Drug	procaine	CACNA1B CACNB2 PKD1 SCN9A CACNA1I	6.10e-05	153	62	5	CID000004914
Drug	nisoldipine	CACNA1B CACNB2 PKD1 CACNA1I	6.11e-05	78	62	4	CID000004499
Drug	N-cyclopentyl-N-cyclobutylformamide	CACNA1B CACNB2 PKD1 CACNA1I	6.43e-05	79	62	4	CID005287890
Drug	gabapentin	CACNA1B CACNB2 PKD1 SCN9A CACNA1I	9.76e-05	169	62	5	CID000003446
Drug	felodipine	CACNA1B CACNB2 PKD1 CACNA1I CYP4F12	9.76e-05	169	62	5	CID000003333
Drug	3,4-dihydroquinazoline	CACNA1B CACNA1I	1.09e-04	6	62	2	CID000583065
Drug	riluzole	CACNA1B CACNB2 PKD1 SCN9A CACNA1I	1.12e-04	174	62	5	CID000005070
Drug	AC1NUZ8M	CACNA1B CACNB2 PKD1 CACNA1I	1.16e-04	92	62	4	CID000073211
Drug	manidipine	CACNA1B CACNB2 PKD1 CACNA1I	1.32e-04	95	62	4	CID000004008
Drug	NSC7524	CACNA1B CACNB2 PKD1 SCN9A CACNA1I	1.38e-04	182	62	5	CID000005657
Drug	isotetrandrine	CACNA1B CACNB2 PKD1 CACNA1I	1.43e-04	97	62	4	CID000005422
Drug	nitrendipine	CACNA1B CACNB2 PKD1 CACNA1I	1.49e-04	98	62	4	CID000004507
Drug	Amlodipine	CACNA1B CACNB2	1.52e-04	7	62	2	DB00381
Drug	cytochalasin B; Down 200; 20.8uM; MCF7; HT_HG-U133A_EA	ELOA SLC4A7 CDK12 MEPCE ZNF611	1.57e-04	187	62	5	1122_DN
Drug	Tolazamide [1156-19-0]; Up 200; 12.8uM; MCF7; HT_HG-U133A	USP36 CACNB2 SLC4A7 CACNA1I RIMS2	1.82e-04	193	62	5	2842_UP
Drug	Minaprine dihydrochloride [25953-17-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A	USP36 ZC3H13 ATAD2B ZNF696 RIMS2	1.91e-04	195	62	5	4814_UP
Drug	loperamide	CACNA1B CACNB2 PKD1 CACNA1I	1.94e-04	105	62	4	CID000003954
Drug	pyraclofos	CACNA1B CACNB2 SCN9A CACNA1I	2.01e-04	106	62	4	CID000093460
Drug	Talampicillin hydrochloride [39878-70-1]; Up 200; 7.8uM; MCF7; HT_HG-U133A	USP36 ZC3H13 ZNF611 CACNA1I RIMS2	2.05e-04	198	62	5	3515_UP
Drug	amiloride	CACNA1B CACNB2 SLC4A7 PKD1 SCN9A CACNA1I	2.14e-04	315	62	6	CID000016230
Drug	Gentamicine sulfate [1405-41-0]; Down 200; 2.6uM; PC3; HT_HG-U133A	CEP350 SNIP1 VPS13D OTUD3 CASZ1	2.14e-04	200	62	5	5883_DN
Disease	cryptic phenotype measurement	CACNB2 SLC4A7 CASZ1	1.10e-04	47	58	3	EFO_0021487
Disease	systolic blood pressure, alcohol consumption measurement	CACNB2 SLC4A7 CASZ1	1.10e-04	47	58	3	EFO_0006335, EFO_0007878
Disease	autism spectrum disorder (implicated_via_orthology)	PRICKLE1 CHD8 CHD1 RIMS2	2.31e-04	152	58	4	DOID:0060041 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP36 USP42 CHD8	3.44e-04	69	58	3	DOID:1682 (implicated_via_orthology)
Disease	pulse pressure measurement, alcohol drinking	CACNB2 SLC4A7 CASZ1	3.59e-04	70	58	3	EFO_0004329, EFO_0005763
Disease	anemia (implicated_via_orthology)	SLC4A7 SLC4A10	3.92e-04	15	58	2	DOID:2355 (implicated_via_orthology)
Disease	hippocampal tail volume	STOX2 SLC4A10	6.36e-04	19	58	2	EFO_0009398
Disease	Epilepsy	SCN9A SLC4A10 ANKRD11	1.31e-03	109	58	3	C0014544
Disease	Beta blocking agent use measurement	CACNB2 SLC4A7 CASZ1	1.48e-03	114	58	3	EFO_0009929
Disease	response to angiotensin receptor blocker	CACNB2 STOX2	1.59e-03	30	58	2	EFO_0010735
Disease	mean arterial pressure, unipolar depression	CACNB2 CASZ1	1.81e-03	32	58	2	EFO_0003761, EFO_0006340
Disease	systolic blood pressure, alcohol drinking	CACNB2 SLC4A7 CASZ1	2.07e-03	128	58	3	EFO_0004329, EFO_0006335
Disease	mean arterial pressure	USP36 CACNB2 SLC4A7 SLC4A10 CASZ1	2.97e-03	499	58	5	EFO_0006340
Disease	smoking status measurement, systolic blood pressure	CACNB2 SLC4A7 CASZ1	3.61e-03	156	58	3	EFO_0006335, EFO_0006527
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP36 USP42	3.72e-03	46	58	2	DOID:5426 (implicated_via_orthology)
Disease	smoking status measurement, diastolic blood pressure	CACNB2 SLC4A7 CASZ1	3.81e-03	159	58	3	EFO_0006336, EFO_0006527
Disease	epilepsy (implicated_via_orthology)	CACNA1B PRICKLE1 SCN9A	4.09e-03	163	58	3	DOID:1826 (implicated_via_orthology)
Disease	mean reticulocyte volume	CEP350 KLF16 ATAD2B TMCC2 ZNF888 CHD1	4.74e-03	799	58	6	EFO_0010701
Disease	pulse pressure measurement	USP36 CACNB2 PRDM9 SLC4A7 ATAD2B PKD1 ANKRD11 CASZ1	5.65e-03	1392	58	8	EFO_0005763
Disease	heart failure	USP36 CACNB2 PKD1	5.81e-03	185	58	3	EFO_0003144

Protein segments in the cluster

Peptide	Gene	Start	Entry
HSRSSRKHRDRRDRH	VANGL2	16	Q9ULK5
AARHRARAHPHARKQ	CBARP	566	Q8N350
DDERPRSRRHDRHHA	CHD8	1426	Q9HCK8
NSRERHRLVSKHKRH	CDK12	31	Q9NYV4
GSDRSDRLHKHRHHQ	CDK12	101	Q9NYV4
DRLHKHRHHQHRRSR	CDK12	106	Q9NYV4
HRHHQHRRSRDLLKA	CDK12	111	Q9NYV4
HRDRHADGLLRHHRD	ANKRD11	1476	Q6UB99
RHHRDELLRHHRDEQ	ANKRD11	1486	Q6UB99
TSHKRKHERRHIRSS	CASZ1	686	Q86V15
KKHRHERGHHRDRRE	CCNL1	486	Q9UK58
ARRHRARHKAQPAHE	CACNA1B	976	Q00975
REKHRKLDDHRSRDH	CHD1	1601	O14646
GSSDHRHRESRHRSR	CACNB2	596	Q08289
ATRRKRHSEHAFDHA	ENTPD3	511	O75355
FTRSDHLAKHARRHP	KLF16	196	Q9BXK1
LKTGRKRHRHRGQHH	MEPCE	256	Q7L2J0
RRSHIRRKKHAIHSS	ATAD2B	321	Q9ULI0
HSHHLSARVRGRTER	ELAPOR1	6	Q6UXG2
RDHRHSRDLRDHRDS	NCOA5	61	Q9HCD5
RHESEEGDSHRRHKH	FIP1L1	551	Q6UN15
RHRHKALESRGSHRD	OTUD3	361	Q5T2D3
SHALLRDGALRHRHE	KIF19	581	Q2TAC6
IHAEVSRARHERRHS	RIMS2	386	Q9UQ26
GFRDKSHLLRHQRTH	PRDM9	756	Q9NQV7
HHHRRRRSRKSRSDN	PRICKLE1	671	Q96MT3
EGRERDHELRHRRHH	MUC7	21	Q8TAX7
VSHGHERRDERKRCH	ELOA	171	Q14241
QRSKHSSRHHRDKER	FAM117B	291	Q6P1L5
LAHRHRHHRRTLSLD	CACNA1I	1046	Q9P0X4
HDGRRFHRACRLVHD	CYP4F12	251	Q9HCS2
ESHRRFNMEKRRGHH	CEP350	1631	Q5VT06
RERRENGRHTHRHTH	FAM27D1	101	Q5T7N8
HRHLDGDRAFHRNSL	PKD1	3151	P98161
RKSSHHRKAGESHRR	GARIN3	441	Q8TC56
HRKAGESHRRRAGDK	GARIN3	446	Q8TC56
HSHGRGERHRSLDRR	DROSHA	236	Q9NRR4
RNSDRDRHRGHSHQR	SNIP1	136	Q8TAD8
FSKESRRRHRHRGHK	SLC4A7	51	Q9Y6M7
GHGLKHLFHSRRRSR	TMCC2	81	O75069
HLFHSRRRSREREHQ	TMCC2	86	O75069
RKSFHLGVEGHRRAH	SCN9A	511	Q15858
PDHTRSRRSHSKDRH	AKAP17A	641	Q02040
DSHHHLVADAIRRDR	PGBD2	206	Q6P3X8
RHQKTHSAERHRRGP	ZNF837	316	Q96EG3
ARESRSKTEGHRHRR	USP42	966	Q9H9J4
RRSLGRCSHHHSRHR	USP42	1011	Q9H9J4
SEKDHSRPHKHRARH	SYNPO2	341	Q9UMS6
KVHRSHSHTQDRRSR	STOX2	466	Q9P2F5
SHRRHRHRGHKHRKR	SLC4A10	61	Q6U841
RHRGHKHRKRDRERD	SLC4A10	66	Q6U841
RSDAAKHRRTHTGER	ZNF696	221	Q9H7X3
RDRRHRSRSKSPGHH	PRPF38A	271	Q8NAV1
SRHRGDKPAHRRFHR	ZNF697	151	Q5TEC3
SRKSHLERHRRIHTG	ZNF888	476	P0CJ79
GSHLARHRRTHTGER	ZNF316	731	A6NFI3
TRRSAHFKHQRLHTR	ZNF418	601	Q8TF45
RRSHLTRHQRIHSGE	ZNF543	266	Q08ER8
FRCKSHLERHRRIHT	ZNF28	476	P17035
SRKSHMERHRRIHTG	ZNF28	561	P17035
RSSLHCHRRLHSGEK	ZNF611	606	Q8N823
RHRKAHGRTRTHECS	ZNF530	256	Q6P9A1
FSRKSHLERHRRIHT	ZNF701	401	Q9NV72
QRGDVTIDRRHRAHH	PLEKHA5	571	Q9HAU0
RRRAHLTEHTRLHSG	ZNF425	536	Q6IV72
RKERDGERHHSHKRR	SNRNP48	321	Q6IEG0
RKSFRQRAHLAHHER	ZNF583	526	Q96ND8
DGHHASSRKRRRKGA	USP36	906	Q9P275
REKGRHDHERTSQSH	ZC3H13	396	Q5T200
SRRENLARHHRLHAG	ZNF816	491	Q0VGE8
RHNCKRRAHEREHTG	ZNF311	481	Q5JNZ3
RGKLRHRHTHDLRIH	VPS13D	2956	Q5THJ4