Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeletal protein binding	DIP2B MYH3 KATNAL2 MYH10 ABL1 EML6 ESPNL NCKIPSD NUMA1 EEF2 TTBK1 PDCD5 FES PLEC TRAPPC14 NOS2 DMTN	2.00e-05	1099	97	17	GO:0008092
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR1 ITPR3	6.98e-05	3	97	2	GO:0005220
GeneOntologyMolecularFunction	actin filament binding	MYH3 MYH10 ABL1 ESPNL EEF2 PLEC DMTN	1.21e-04	227	97	7	GO:0051015
GeneOntologyBiologicalProcess	cell morphogenesis	DIP2B ASXL1 MYH10 ABL1 BBS1 SPG11 NIBAN2 CHRNB2 ITPR1 CSNK1A1L HMCN2 CELSR3 PLPPR4 CSNK1A1 FES FGD5 SCRIB PLEC NOTCH1 DMTN	8.17e-07	1194	99	20	GO:0000902
GeneOntologyCellularComponent	platelet dense tubular network membrane	ITPR1 ITPR3 DMTN	7.97e-06	9	97	3	GO:0031095
GeneOntologyCellularComponent	platelet dense tubular network	ITPR1 ITPR3 DMTN	1.56e-05	11	97	3	GO:0031094
GeneOntologyCellularComponent	neuronal cell body	DIP2B MYH10 CAD ABL1 MAOB PCLO NUMA1 SEZ6L2 ITPR1 ITPR3 RIN1 TTBK1 HMCN2	1.26e-04	835	97	13	GO:0043025
GeneOntologyCellularComponent	somatodendritic compartment	DIP2B MYH10 CAD ABL1 MAOB PCLO NUMA1 SPG11 MAGEE1 SEZ6L2 ITPR1 ITPR3 RIN1 TTBK1 HMCN2 PLEC	1.60e-04	1228	97	16	GO:0036477
GeneOntologyCellularComponent	sarcoplasm	MYH10 ITPR1 ITPR3 JPH1 PLEC	1.91e-04	114	97	5	GO:0016528
GeneOntologyCellularComponent	cell body	DIP2B MYH10 CAD ABL1 MAOB PCLO NUMA1 SEZ6L2 ITPR1 ITPR3 RIN1 TTBK1 HMCN2	3.56e-04	929	97	13	GO:0044297
GeneOntologyCellularComponent	perinuclear region of cytoplasm	ABL1 UACA PCLO SEC31A MAGEE1 ITPR1 ITPR3 OSBP TTBK1 SBF1 PLEC NOS2 DMTN	3.75e-04	934	97	13	GO:0048471
GeneOntologyCellularComponent	dendrite	DIP2B MYH10 ABL1 MAOB PCLO NUMA1 SPG11 MAGEE1 ITPR1 ITPR3 RIN1 PLEC	6.12e-04	858	97	12	GO:0030425
GeneOntologyCellularComponent	dendritic tree	DIP2B MYH10 ABL1 MAOB PCLO NUMA1 SPG11 MAGEE1 ITPR1 ITPR3 RIN1 PLEC	6.25e-04	860	97	12	GO:0097447
GeneOntologyCellularComponent	postsynapse	MYH10 ABL1 RNF19A PCLO MAGEE1 PCDH17 CHRNB2 ITPR1 CELSR3 PLPPR4 SCRIB NOTCH1 DMTN	8.40e-04	1018	97	13	GO:0098794
GeneOntologyCellularComponent	supramolecular fiber	MYH3 KATNAL2 MYH10 EML6 NCKIPSD NUMA1 MYOM3 RIBC1 JPH1 CSNK1A1L CSNK1A1 PLEC DMTN SMTNL2	1.06e-03	1179	97	14	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	MYH3 KATNAL2 MYH10 EML6 NCKIPSD NUMA1 MYOM3 RIBC1 JPH1 CSNK1A1L CSNK1A1 PLEC DMTN SMTNL2	1.13e-03	1187	97	14	GO:0099081
GeneOntologyCellularComponent	beta-catenin destruction complex	CSNK1A1L CSNK1A1	1.61e-03	13	97	2	GO:0030877
Domain	InsP3_rcpt-bd	ITPR1 ITPR3	8.15e-05	3	98	2	IPR000493
Domain	RIH_assoc-dom	ITPR1 ITPR3	4.03e-04	6	98	2	IPR013662
Domain	Ins145_P3_rec	ITPR1 ITPR3	4.03e-04	6	98	2	PF08709
Domain	RIH_assoc	ITPR1 ITPR3	4.03e-04	6	98	2	PF08454
Domain	RIH_dom	ITPR1 ITPR3	4.03e-04	6	98	2	IPR000699
Domain	Ins145_P3_rcpt	ITPR1 ITPR3	4.03e-04	6	98	2	IPR014821
Domain	Ryanodine_recept-rel	ITPR1 ITPR3	4.03e-04	6	98	2	IPR015925
Domain	-	ITPR1 ITPR3	4.03e-04	6	98	2	1.25.10.30
Domain	RYDR_ITPR	ITPR1 ITPR3	4.03e-04	6	98	2	PF01365
Domain	FYVE	RUFY1 ZFYVE28 FGD5	4.64e-04	29	98	3	PF01363
Domain	FYVE	RUFY1 ZFYVE28 FGD5	4.64e-04	29	98	3	SM00064
Domain	Znf_FYVE-rel	RUFY1 ZFYVE28 FGD5	7.45e-04	34	98	3	IPR017455
Domain	Znf_FYVE	RUFY1 ZFYVE28 FGD5	1.03e-03	38	98	3	IPR000306
Domain	MIR	ITPR1 ITPR3	1.19e-03	10	98	2	PF02815
Domain	MIR_motif	ITPR1 ITPR3	1.19e-03	10	98	2	IPR016093
Domain	MIR	ITPR1 ITPR3	1.19e-03	10	98	2	PS50919
Domain	MIR	ITPR1 ITPR3	1.19e-03	10	98	2	SM00472
Domain	ZF_FYVE	RUFY1 ZFYVE28 FGD5	1.20e-03	40	98	3	PS50178
Domain	Quinoprotein_ADH-like_supfam	NWD1 EML6 BBS1	2.71e-03	53	98	3	IPR011047
Domain	Myosin_N	MYH3 MYH10	2.74e-03	15	98	2	PF02736
Domain	Myosin_N	MYH3 MYH10	2.74e-03	15	98	2	IPR004009
Domain	Myosin_tail_1	MYH3 MYH10	3.95e-03	18	98	2	PF01576
Domain	Myosin_tail	MYH3 MYH10	3.95e-03	18	98	2	IPR002928
Domain	Myosin-like_IQ_dom	MYH3 MYH10	4.40e-03	19	98	2	IPR027401
Domain	-	MYH3 MYH10	4.40e-03	19	98	2	4.10.270.10
Domain	Apc4_WD40_dom	NWD1 EML6	4.87e-03	20	98	2	IPR024977
Domain	ANAPC4_WD40	NWD1 EML6	4.87e-03	20	98	2	PF12894
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	MYH10 CAD UACA SMCHD1 NUMA1 PRPF8 ITPR3 SBF1 PLEC	7.58e-09	202	100	9	33005030
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	ASXL1 ABL1 RNF19A EML6 NUMA1 PRPF8 SBF1 AMOTL1 SCRIB PLEC	4.44e-08	332	100	10	37433992
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	MYH10 CAD UACA SMCHD1 NUMA1 PRPF8 ARHGEF11 ITPR3 KIAA1671 CSNK1A1 SCRIB PLEC	4.53e-07	660	100	12	32780723
Pubmed	Aerobic glycolysis tunes YAP/TAZ transcriptional activity.	MYH10 CAD WWC3 NUMA1 PRPF8 PSMD6 AMOTL1	4.65e-07	162	100	7	25796446
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TMEM120B ABL1 MYOM3 ARHGEF11 CTDSP2 ITPR3 FANCA CELSR3 SBF1 PLEC HERC1 SIPA1L2 ANKRD33B ABTB2 NOTCH1	6.28e-07	1105	100	15	35748872
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	MYH10 CAD PCLO NCKIPSD ARHGEF11 ELP3 PSMD6 RIN1 EEF2 CSNK1A1L SBF1 PLPPR4 CSNK1A1 SCRIB PLEC SIPA1L2 DMTN	6.62e-07	1431	100	17	37142655
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DIP2B MYH10 CAD UACA USP28 NUMA1 SEC31A ARHGEF11 EEF2 CSNK1A1L SBF1 PLPPR4 CSNK1A1 SCRIB	6.88e-07	963	100	14	28671696
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DIP2B ABL1 NCKIPSD ALPK1 KIAA1671 SBF1 CSNK1A1 SCRIB PLEC TRAPPC14 SIPA1L2 ABTB2 DMTN	1.17e-06	861	100	13	36931259
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	DIP2B MYH10 SMCHD1 PCLO NUMA1 PRPF8 CSNK1A1 SCRIB ILVBL PLIN3	1.81e-06	498	100	10	36634849
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	MYH10 CAD SMCHD1 NUMA1 PRPF8 EEF2 SCRIB	2.04e-06	202	100	7	24639526
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	KATNAL2 MYH10 CAD UACA NUMA1 PRPF8 ITPR1 ITPR3 JPH1 EEF2 CSNK1A1 SCRIB PLEC	3.41e-06	949	100	13	36574265
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	CAD NUMA1 GON4L PRPF8 EEF2 PLEC HERC1	5.37e-06	234	100	7	36243803
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	SIKE1 NCKIPSD KIAA1671 AMOTL1 TRAPPC14 SIPA1L2 ILVBL NOTCH1 DMTN	5.87e-06	446	100	9	24255178
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	SIKE1 CAD UACA PRPF8 ELP3 PSMD6 INTS13 PDCD5 HERC1 ILVBL	6.25e-06	573	100	10	28330616
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	TMEM120B UACA NIBAN2 SEC31A ELP3 FANCA KIAA1671 RIN1 FADS3 SCRIB HERC1	7.30e-06	719	100	11	35337019
Pubmed	Localization of the cellular oncogenes ABL, SIS, and FES on human germ-line chromosomes.	ABL1 FES	8.18e-06	2	100	2	6323103
Pubmed	Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells.	CSNK1A1L CSNK1A1	8.18e-06	2	100	2	23354688
Pubmed	The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change.	ITPR1 ITPR3	8.18e-06	2	100	2	15890645
Pubmed	Tissue-specific distribution of mouse casein kinase I alpha mRNA.	CSNK1A1L CSNK1A1	8.18e-06	2	100	2	9522121
Pubmed	CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling.	CSNK1A1L CSNK1A1	8.18e-06	2	100	2	37723657
Pubmed	Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.	CSNK1A1L CSNK1A1	8.18e-06	2	100	2	36929849
Pubmed	The Giant HECT E3 Ubiquitin Ligase HERC1 Is Aberrantly Expressed in Myeloid Related Disorders and It Is a Novel BCR-ABL1 Binding Partner.	ABL1 HERC1	8.18e-06	2	100	2	33477751
Pubmed	Class III β-Tubulin Expression Is of Value in Selecting nab -Paclitaxel and Gemcitabine as First-Line Therapy in Unresectable Pancreatic Cancer.	CSNK1A1L CSNK1A1	8.18e-06	2	100	2	35695793
Pubmed	Exploring the role of casein kinase 1α splice variants across cancer cell lines.	CSNK1A1L CSNK1A1	8.18e-06	2	100	2	38852281
Pubmed	Casein kinase 1 alpha regulates chromosome congression and separation during mouse oocyte meiotic maturation and early embryo development.	CSNK1A1L CSNK1A1	8.18e-06	2	100	2	23690993
Pubmed	Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells.	ITPR1 ITPR3	8.18e-06	2	100	2	7559486
Pubmed	Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.	ITPR1 ITPR3	8.18e-06	2	100	2	20843799
Pubmed	Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis.	NOS2 NOTCH1	8.18e-06	2	100	2	15887117
Pubmed	Knockdown of Csnk1a1 results in preimplantation developmental arrest in mice.	CSNK1A1L CSNK1A1	8.18e-06	2	100	2	36542875
Pubmed	Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor.	ITPR1 ITPR3	8.18e-06	2	100	2	8663526
Pubmed	Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism.	CSNK1A1L CSNK1A1	8.18e-06	2	100	2	25994086
Pubmed	ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice.	ABL1 NOTCH1	8.18e-06	2	100	2	32171747
Pubmed	Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.	ITPR1 ITPR3	8.18e-06	2	100	2	1374893
Pubmed	Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening.	ITPR1 ITPR3	8.18e-06	2	100	2	20813840
Pubmed	Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma.	CSNK1A1L CSNK1A1	8.18e-06	2	100	2	34216174
Pubmed	Casein Kinase 1α as a Novel Factor Affects Thyrotropin Synthesis via PKC/ERK/CREB Signaling.	CSNK1A1L CSNK1A1	8.18e-06	2	100	2	37108197
Pubmed	Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.	ABL1 FES	8.18e-06	2	100	2	18775312
Pubmed	Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling.	ITPR1 ITPR3	8.18e-06	2	100	2	14707143
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MYH10 CAD NIBAN2 ELP3 CTDSP2 ITPR1 ITPR3 KIAA1671 PSMD6 SBF1 SCRIB HERC1 NOTCH1	9.99e-06	1049	100	13	27880917
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	UACA GON4L VAT1L MAGEE1 ZFYVE28	1.13e-05	101	100	5	10997877
Pubmed	Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment.	MYH10 CAD SMCHD1 SEC31A PRPF8 EEF2 CSNK1A1 SCRIB PLEC	1.26e-05	491	100	9	22623428
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	UACA ITPR1 FANCA AMOTL1 ARMC6	1.30e-05	104	100	5	31240132
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	MYH10 CAD UACA SMCHD1 NUMA1 PRPF8 ITPR3 KIAA1671 EEF2 CSNK1A1 AMOTL1 SCRIB PLEC DMTN	1.47e-05	1257	100	14	36526897
Pubmed	Identification of FBXO25-interacting proteins using an integrated proteomics approach.	MYH10 CAD UACA PSMD6 EEF2	1.87e-05	112	100	5	20473970
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	MYH10 GNE NUMA1 PRPF8 ELP3 PSMD6 OSBP EEF2 SCRIB ARMC6	1.93e-05	653	100	10	33742100
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR1 ITPR3	2.45e-05	3	100	2	10874040
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR1 ITPR3	2.45e-05	3	100	2	20395455
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR1 ITPR3	2.45e-05	3	100	2	17437169
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR1 ITPR3	2.45e-05	3	100	2	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR1 ITPR3	2.45e-05	3	100	2	36350267
Pubmed	The versatility and universality of calcium signalling.	ITPR1 ITPR3	2.45e-05	3	100	2	11413485
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR3	2.45e-05	3	100	2	26009177
Pubmed	Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.	CSNK1A1L CSNK1A1	2.45e-05	3	100	2	24616378
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR1 ITPR3	2.45e-05	3	100	2	1693919
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR1 ITPR3	2.45e-05	3	100	2	23955339
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR1 ITPR3	2.45e-05	3	100	2	31979185
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR1 ITPR3	2.45e-05	3	100	2	24904548
Pubmed	Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.	CSNK1A1L CSNK1A1	2.45e-05	3	100	2	25242043
Pubmed	Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.	CSNK1A1L CSNK1A1	2.45e-05	3	100	2	28655862
Pubmed	Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.	ITPR1 ITPR3	2.45e-05	3	100	2	18250332
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR1 ITPR3	2.45e-05	3	100	2	9858485
Pubmed	A secreted protein promotes cleavage furrow maturation during cytokinesis.	MYH10 HMCN2	2.45e-05	3	100	2	21215633
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR1 ITPR3	2.45e-05	3	100	2	9808793
Pubmed	Nitric oxide is involved in Mycobacterium bovis bacillus Calmette-Guérin-activated Jagged1 and Notch1 signaling.	NOS2 NOTCH1	2.45e-05	3	100	2	20147635
Pubmed	Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney.	ITPR1 ITPR3	2.45e-05	3	100	2	22992961
Pubmed	CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation.	CSNK1A1L CSNK1A1	2.45e-05	3	100	2	28878021
Pubmed	Type I Interferons Control Proliferation and Function of the Intestinal Epithelium.	CSNK1A1L CSNK1A1	2.45e-05	3	100	2	26811327
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR1 ITPR3	2.45e-05	3	100	2	18194433
Pubmed	Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling.	USP28 NUMA1	2.45e-05	3	100	2	34962618
Pubmed	Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling.	CSNK1A1L CSNK1A1	2.45e-05	3	100	2	19805514
Pubmed	Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.	ITPR1 ITPR3	2.45e-05	3	100	2	12032348
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR1 ITPR3	2.45e-05	3	100	2	27777977
Pubmed	Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.	ITPR1 ITPR3	2.45e-05	3	100	2	17581770
Pubmed	Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.	ITPR1 ITPR3	2.45e-05	3	100	2	18241669
Pubmed	Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.	ITPR1 ITPR3	2.45e-05	3	100	2	19068129
Pubmed	Ubiquitination and proteasomal degradation of endogenous and exogenous inositol 1,4,5-trisphosphate receptors in alpha T3-1 anterior pituitary cells.	ITPR1 ITPR3	2.45e-05	3	100	2	12421829
Pubmed	Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR3	2.45e-05	3	100	2	17327232
Pubmed	Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.	ITPR1 ITPR3	2.45e-05	3	100	2	16014380
Pubmed	Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.	ITPR1 ITPR3	2.45e-05	3	100	2	17890015
Pubmed	Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.	ITPR1 ITPR3	2.45e-05	3	100	2	23983250
Pubmed	Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.	ITPR1 ITPR3	2.45e-05	3	100	2	20427533
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	CAD SMCHD1 NUMA1 RUFY1 KIAA1671 PDCD5 AMOTL1 SCRIB PLIN3	3.04e-05	549	100	9	38280479
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	ASXL1 MYH10 USP28 BBS1 NIBAN2 PRPF8 PSMD6 PDCD5 AMOTL1 SCRIB NUDCD1 PLEC	3.23e-05	1005	100	12	19615732
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	UACA NIBAN2 KIAA1671 EEF2 CSNK1A1 SCRIB PLEC PLIN3 NOTCH1	3.79e-05	565	100	9	25468996
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	CAD NUMA1 NIBAN2 SEC31A JPH1 PSMD6 EEF2 SCRIB PLIN3 NOTCH1	3.83e-05	708	100	10	39231216
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	NUMA1 NIBAN2 RUFY1 ITPR1 ITPR3 JPH1 FADS3 PDCD5 PLIN3	3.95e-05	568	100	9	37774976
Pubmed	TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis.	EEF2 CSNK1A1L CSNK1A1 ILVBL	4.29e-05	67	100	4	35670107
Pubmed	Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.	ITPR1 ITPR3	4.89e-05	4	100	2	25215520
Pubmed	The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic.	CSNK1A1L CSNK1A1	4.89e-05	4	100	2	32728212
Pubmed	The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage.	ITPR1 ITPR3	4.89e-05	4	100	2	23884412
Pubmed	Cloning, analysis, and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch.	ABL1 NOTCH1	4.89e-05	4	100	2	8449489
Pubmed	Regulation of p53-MDMX interaction by casein kinase 1 alpha.	CSNK1A1L CSNK1A1	4.89e-05	4	100	2	16024788
Pubmed	Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR3	4.89e-05	4	100	2	11163362
Pubmed	A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.	CSNK1A1L CSNK1A1	4.89e-05	4	100	2	30487124
Pubmed	Stabilization of cortical actin induces internalization of transient receptor potential 3 (Trp3)-associated caveolar Ca2+ signaling complex and loss of Ca2+ influx without disruption of Trp3-inositol trisphosphate receptor association.	ITPR1 ITPR3	4.89e-05	4	100	2	11524429
Pubmed	Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation.	CSNK1A1L CSNK1A1	4.89e-05	4	100	2	38147624
Pubmed	Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.	ITPR1 ITPR3	4.89e-05	4	100	2	21424589
Pubmed	Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.	ITPR1 ITPR3	4.89e-05	4	100	2	28615414
Pubmed	Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.	ITPR1 ITPR3	4.89e-05	4	100	2	10828023
Pubmed	Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.	ITPR1 ITPR3	4.89e-05	4	100	2	14685260
Interaction	LRRC31 interactions	MYH10 CAD UACA SMCHD1 NUMA1 PRPF8 ITPR3 SBF1 PLEC	8.37e-07	205	100	9	int:LRRC31
Interaction	YWHAZ interactions	ASXL1 MYH10 CAD ABL1 UACA NCKIPSD PRPF8 RUFY1 ITPR1 KIAA1671 RIN1 SBF1 CSNK1A1 SRSF8 AMOTL1 SCRIB PLEC SIPA1L2 NOS2 DMTN SMTNL2	1.62e-06	1319	100	21	int:YWHAZ
Interaction	EEF1AKMT3 interactions	SMCHD1 SPG11 NIBAN2 RUFY1 FANCA KIAA1671 RIN1 SBF1 PDCD5 HERC1 ARMC6	1.93e-06	364	100	11	int:EEF1AKMT3
Interaction	YWHAQ interactions	CAD ABL1 UACA NCKIPSD NUMA1 PRPF8 RUFY1 KIAA1671 EEF2 SBF1 CSNK1A1 FGD5 SCRIB PLEC SIPA1L2 NOS2 DMTN SMTNL2	8.74e-06	1118	100	18	int:YWHAQ
Interaction	PTGES3 interactions	DIP2B CAD ABL1 BBS1 PRPF8 ELP3 OSBP SBF1 CSNK1A1 FES NOS2	1.10e-05	437	100	11	int:PTGES3
Interaction	RNF213 interactions	UACA VSIG4 RUFY1 TRIM23 ITPR3 OSBP SCRIB	1.12e-05	153	100	7	int:RNF213
Interaction	MEX3A interactions	ASXL1 ABL1 RNF19A EML6 NUMA1 PRPF8 SBF1 AMOTL1 SCRIB PLEC	2.12e-05	384	100	10	int:MEX3A
Interaction	FLOT1 interactions	DIP2B CAD PCLO NIBAN2 JPH1 FGD5 SCRIB PLEC SIPA1L2 ILVBL NOTCH1	2.38e-05	475	100	11	int:FLOT1
Interaction	KRT18 interactions	CAD SMCHD1 BBS1 PRPF8 ITPR3 KIAA1671 FGD5 PLEC SIPA1L2 NOS2	4.43e-05	419	100	10	int:KRT18
Interaction	CAPZA2 interactions	ASXL1 MYH10 NCKIPSD NUMA1 ITPR1 ITPR3 KIAA1671 AMOTL1 NUDCD1 PLEC	5.51e-05	430	100	10	int:CAPZA2
Interaction	KIF20A interactions	MYH10 UACA PCLO EML6 NUMA1 PRPF8 ITPR1 KIAA1671 EEF2 CSNK1A1L CSNK1A1 SRSF8 PLEC HERC1 CCDC171 ILVBL	5.84e-05	1052	100	16	int:KIF20A
Interaction	HSP90AB1 interactions	ASXL1 NCKIPSD NUMA1 SPG11 SEC31A PRPF8 RUFY1 FANCA KIAA1671 EEF2 HYPK CSNK1A1 FGD5 NOS2 NOTCH1	7.55e-05	960	100	15	int:HSP90AB1
Interaction	CIT interactions	MYH10 CAD USP28 SMCHD1 PCLO NCKIPSD NUMA1 SEC31A PRPF8 ELP3 ITPR3 KIAA1671 EEF2 CSNK1A1L SRSF8 SCRIB PLEC HERC1 SMTNL2	8.24e-05	1450	100	19	int:CIT
Interaction	MCC interactions	MYH10 UACA MAGEE1 JPH1 CSNK1A1 ZNF648 SCRIB	9.86e-05	215	100	7	int:MCC
Interaction	YWHAH interactions	DIP2B ABL1 UACA NCKIPSD KIAA1671 RIN1 SBF1 CSNK1A1 SRSF8 SCRIB PLEC HERC1 TRAPPC14 SIPA1L2 DMTN SMTNL2	1.01e-04	1102	100	16	int:YWHAH
Interaction	PIP4K2B interactions	CAD PRPF8 CSNK1A1L CSNK1A1 SCRIB	1.16e-04	96	100	5	int:PIP4K2B
Interaction	YWHAG interactions	MYH10 CAD ABL1 UACA NCKIPSD KIAA1671 RIN1 TTBK1 SBF1 CSNK1A1 SRSF8 SCRIB TRAPPC14 SIPA1L2 NOS2 DMTN SMTNL2	1.30e-04	1248	100	17	int:YWHAG
Interaction	BRCA1 interactions	RPGRIP1 MYH10 CAD ABL1 USP28 SMCHD1 NUMA1 SEC31A RUFY1 ITPR1 FANCA PSMD6 EEF2 SAGE1 PLEC HERC1 PLIN3	1.31e-04	1249	100	17	int:BRCA1
Interaction	FBXW8 interactions	CAD PCLO VWA7 TTBK1 PDCD5 SIPA1L2	1.32e-04	157	100	6	int:FBXW8
Interaction	NUPR1 interactions	MYH10 CAD UACA SMCHD1 NUMA1 PRPF8 ARHGEF11 ITPR3 KIAA1671 CSNK1A1 SCRIB PLEC	1.43e-04	683	100	12	int:NUPR1
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR1 ITPR3	3.35e-05	3	61	2	297
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	RUFY1 ZFYVE28 FGD5	1.54e-04	31	61	3	81
GeneFamily	Myosin heavy chains	MYH3 MYH10	1.14e-03	15	61	2	1098
GeneFamily	Ankyrin repeat domain containing	UACA ESPNL ANKRD33B ABTB2 NOTCH1	1.33e-03	242	61	5	403
GeneFamily	PDZ domain containing	PCLO ARHGEF11 SCRIB SIPA1L2	1.73e-03	152	61	4	1220
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO CHRNB2 FANCA OSBP HERC1 ANKRD33B	2.71e-06	174	100	6	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH10 UACA EID2 PCLO SEZ6L2 TTBK1	3.98e-06	186	100	6	f5468e03321ea2083e223eb0d92c3a9307039569
ToppCell	(01)_Cycling_Basal_(homeostasis)-(1)_24hpi\|(01)_Cycling_Basal_(homeostasis) / shred by cell type and Timepoint	MAOB EML6 ESPNL DPEP2	1.99e-05	71	100	4	6aa56b0daaeb5e0ae30619f9c6945c8e42899b27
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_A\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DIP2B USP28 MAGEE1 AMOTL1 DMTN	2.80e-05	157	100	5	542944030cd9b3f3559e64f9f6598694d74003c0
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	UACA MYOM3 AHRR PLPPR4 FGD5	4.57e-05	174	100	5	18ab52d8bbca0507fee220e0c4fc765fc47dda34
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-early_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UACA KIAA1671 AMOTL1 ANKRD33B SMTNL2	4.82e-05	176	100	5	29cda51a99100ddd2928cadc92da40f001d7e1f4
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-early_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UACA KIAA1671 AMOTL1 ANKRD33B SMTNL2	4.82e-05	176	100	5	01774a86d7d92f31a056b753f9844f923038003e
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO VWA7 ITPR1 TTBK1 PLPPR4	5.09e-05	178	100	5	a74e5a390cbeaca9de1fdb7b2a0e50783bd202dd
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO VWA7 ITPR1 TTBK1 PLPPR4	5.09e-05	178	100	5	1bddbc083c36657bd6910f7466126ab325e88176
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO SEC31A CHRNB2 HERC1 ANKRD33B	5.09e-05	178	100	5	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	facs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM120B USP28 MYOM3 FADS3 SBF1	5.37e-05	180	100	5	7368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l19\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UACA PCDH17 KIAA1671 FGD5 NOTCH1	5.66e-05	182	100	5	840427d1c23d60482c943ff006b14007ed44d247
ToppCell	ILEUM-inflamed-(7)_Lymphatics\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	MYH10 UACA PCLO KIAA1671 DMTN	6.11e-05	185	100	5	d711dd2e91cfee723dae1ccb2b910b8cf3becc3b
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	UACA NIBAN2 KIAA1671 NOS2 NOTCH1	6.43e-05	187	100	5	25efb82afe863a853ecdd781ad89026c993aaa67
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	UACA PCDH17 KIAA1671 FGD5 NOTCH1	6.59e-05	188	100	5	366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NWD1 UACA PCDH17 AMOTL1 FGD5	6.59e-05	188	100	5	0aa8747c2931b0c91f6d78bb2db8fd8ede6dd559
ToppCell	Control-Endothelial-Endothelial-Alv_Gen_Intermediate\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	UACA PCDH17 KIAA1671 FGD5 SIPA1L2	6.76e-05	189	100	5	5d7ae1ead7f4fbaeec26f651833c9c2106e1e4d1
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PCDH17 KIAA1671 FGD5 ANKRD33B NOTCH1	6.76e-05	189	100	5	1e1afa66b32ae752c0a42b02b80f10205464569c
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NWD1 UACA PCDH17 AMOTL1 FGD5	6.93e-05	190	100	5	a08c5929b05a4969852e351a93c4e4deb4c8d5b6
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NWD1 UACA PCDH17 AMOTL1 FGD5	6.93e-05	190	100	5	25525fee1da8a808034d9c916159fd0b6b26bce8
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	UACA PCDH17 KIAA1671 FGD5 SIPA1L2	6.93e-05	190	100	5	a3c6eec6df052105ab78b7e3c78f94218d5912eb
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-C_(Myofibroblast)\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	MYH10 MAOB UACA PLPPR4 SMTNL2	6.93e-05	190	100	5	71e112dfb8c3190fe0286b45a046ea789eb6a8db
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PCDH17 KIAA1671 FGD5 SIPA1L2 NOS2	7.11e-05	191	100	5	1de0bdfd13bd930691564c2673f2e66393bc0255
ToppCell	droplet-Lung-1m-Endothelial-venous_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MAOB PCDH17 RIN1 AMOTL1 FGD5	7.28e-05	192	100	5	1990dc8a81594018a5bf596be99d0b5f0af0f58f
ToppCell	LPS-IL1RA+antiTNF-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	UACA PCDH17 KIAA1671 FGD5 SIPA1L2	7.28e-05	192	100	5	04f5a2e3dd6beff027b89d66eefdd92036e041af
ToppCell	Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|World / Lineage, Cell type, age group and donor	UACA PCDH17 FGD5 SIPA1L2 NOS2	7.28e-05	192	100	5	1e156bab5ecf64627890d2de9b27603d9a01f28d
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	UACA PCDH17 KIAA1671 FGD5 SIPA1L2	7.28e-05	192	100	5	c07d7b40b2aa4eb27ac85801c014a656e2fd01dc
ToppCell	droplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MAOB PCDH17 RIN1 AMOTL1 FGD5	7.28e-05	192	100	5	845cc9c18b4436b07dd3ce7980052683937546d2
ToppCell	droplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MAOB PCDH17 RIN1 AMOTL1 FGD5	7.28e-05	192	100	5	c72a082c93a8825adbfef37f889ba3a7052f201b
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	UACA PCDH17 KIAA1671 FGD5 SIPA1L2	7.46e-05	193	100	5	e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCell	Control-Endothelial-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	UACA PCDH17 KIAA1671 FGD5 SIPA1L2	7.46e-05	193	100	5	aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCell	Control-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	UACA PCDH17 KIAA1671 FGD5 SIPA1L2	7.46e-05	193	100	5	c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCell	Control-Endothelial-Endothelial-Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	UACA PCDH17 KIAA1671 FGD5 SIPA1L2	7.46e-05	193	100	5	e1d546165dcc2392f540162206852c4717d7306f
ToppCell	Hippocampus-Neuronal\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PCLO MAGEE1 CHRNB2 HERC1 DMTN	7.65e-05	194	100	5	8aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell	LPS-IL1RA-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	UACA PCDH17 KIAA1671 FGD5 SIPA1L2	7.65e-05	194	100	5	43f92b0533e26633dc94cce554045d641ef8fd76
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	UACA PCDH17 KIAA1671 FGD5 SIPA1L2	7.65e-05	194	100	5	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	LPS-IL1RA-Endothelial-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	UACA PCDH17 KIAA1671 FGD5 SIPA1L2	7.65e-05	194	100	5	1d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCell	COVID-19-lung-Capillary_Aerocytes\|COVID-19 / Disease (COVID-19 only), tissue and cell type	WWC3 UACA PCDH17 FGD5 SIPA1L2	8.03e-05	196	100	5	49cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYH10 PCLO EML6 ITPR1 PLPPR4	8.42e-05	198	100	5	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Caecum-(6)_Macrophage-(61)_LYVE1_Macrophage\|Caecum / shred on region, Cell_type, and subtype	NWD1 VSIG4 NIBAN2 ARHGEF11 SIPA1L2	8.42e-05	198	100	5	e684c3934c163aef4d284b69435832d2c9614f2a
ToppCell	Caecum-Macrophage-LYVE1_Macrophage\|Caecum / Region, Cell class and subclass	NWD1 VSIG4 NIBAN2 ARHGEF11 SIPA1L2	8.42e-05	198	100	5	a92c0cacb775aca6bbb302bd9e22c081a112a44d
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	UACA PCDH17 FGD5 SIPA1L2 NOS2	8.62e-05	199	100	5	dc88ce36cc066eb6c28cfd5b9b60fe07f8cc7b53
ToppCell	mLN-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	SMCHD1 NUMA1 SPG11 FES HERC1	8.83e-05	200	100	5	e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	UACA NIBAN2 PCDH17 KIAA1671 FGD5	8.83e-05	200	100	5	90061284a80d29a4ca6078f578e13d32b8cc80e1
Drug	AC1L1GFH	CSNK1A1L CSNK1A1 FES MMP1 NOS2	1.25e-06	43	100	5	CID000003660
Drug	Isocaffeine	ITPR1 ITPR3	1.91e-05	2	100	2	CID000001326
Drug	adenophostin B	ITPR1 ITPR3	1.91e-05	2	100	2	CID000656722
Drug	AC1L2K7M	MMP1 NOS2	1.91e-05	2	100	2	CID000073636
Drug	benzene 1,2,4-trisphosphate	ITPR1 ITPR3	1.91e-05	2	100	2	CID000192376
Drug	Esculin Hydrate [531-75-9]; Down 200; 11.8uM; PC3; HT_HG-U133A	TMEM120B NCKIPSD ARHGEF11 ELP3 SBF1 MMP1 NOTCH1	2.48e-05	195	100	7	6310_DN
Drug	Timolol maleate salt [26921-17-5]; Down 200; 9.2uM; MCF7; HT_HG-U133A	TMEM120B MAOB PCLO GON4L FANCA SBF1 DMTN	2.56e-05	196	100	7	5280_DN
Drug	Doxepin hydrochloride [1229-29-4]; Up 200; 12.6uM; MCF7; HT_HG-U133A	NUMA1 TRIM23 CHRNB2 RIN1 EXD3 FADS3 TRAPPC14	2.65e-05	197	100	7	7415_UP
Drug	Ritodrine hydrochloride [23239-51-2]; Down 200; 12.4uM; MCF7; HT_HG-U133A	RNF19A CYP27B1 ALPK1 ARHGEF11 TRIM23 FADS3 TRAPPC14	2.65e-05	197	100	7	2635_DN
Drug	Hydroquinine hydrobromide hydrate [304695-81-6]; Down 200; 9.4uM; MCF7; HT_HG-U133A	TMEM120B CYP27B1 ALPK1 CELSR3 SBF1 PLEC ARMC6	2.74e-05	198	100	7	2767_DN
Drug	Isocorydine (+) [475-67-2]; Down 200; 11.8uM; MCF7; HT_HG-U133A	GNE NCKIPSD ALPK1 CTDSP2 EXD3 SBF1 TRAPPC14	2.74e-05	198	100	7	6843_DN
Drug	Isoxsuprine hydrochloride [579-56-6]; Down 200; 11.8uM; MCF7; HT_HG-U133A	ASXL1 GNE PCLO GON4L CELSR3 SBF1 PLEC	2.92e-05	200	100	7	4789_DN
Disease	syndromic X-linked intellectual disability Najm type (implicated_via_orthology)	CSNK1A1L CSNK1A1	2.13e-04	7	95	2	DOID:0060807 (implicated_via_orthology)
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR1 ITPR3	6.63e-04	12	95	2	DOID:1441 (implicated_via_orthology)
Disease	retinopathy of prematurity (biomarker_via_orthology)	NOS2 NOTCH1	6.63e-04	12	95	2	DOID:13025 (biomarker_via_orthology)
Disease	obesity (implicated_via_orthology)	BBS1 ITPR1 ITPR3 PLIN3 NOTCH1	6.67e-04	215	95	5	DOID:9970 (implicated_via_orthology)
Disease	skin melanoma (is_implicated_in)	FANCA MMP1	9.10e-04	14	95	2	DOID:8923 (is_implicated_in)
Disease	Hypothermia, natural	CHRNB2 NOS2	9.10e-04	14	95	2	C0020672
Disease	myelodysplastic syndrome (implicated_via_orthology)	ASXL1 PRPF8	1.05e-03	15	95	2	DOID:0050908 (implicated_via_orthology)
Disease	Mammary Carcinoma, Human	ABL1 ELP3 EEF2 FGD5 MMP1 NOS2 NOTCH1	1.56e-03	525	95	7	C4704874
Disease	Mammary Neoplasms, Human	ABL1 ELP3 EEF2 FGD5 MMP1 NOS2 NOTCH1	1.56e-03	525	95	7	C1257931
Disease	Mammary Neoplasms	ABL1 ELP3 EEF2 FGD5 MMP1 NOS2 NOTCH1	1.59e-03	527	95	7	C1458155
Disease	Breast Carcinoma	ABL1 ELP3 EEF2 FGD5 MMP1 NOS2 NOTCH1	1.79e-03	538	95	7	C0678222
Disease	esophagus adenocarcinoma (is_implicated_in)	ABL1 MMP1	2.07e-03	21	95	2	DOID:4914 (is_implicated_in)
Disease	Malignant neoplasm of breast	ABL1 MAGEE1 ELP3 RUFY1 ADHFE1 EEF2 FGD5 MMP1 NOS2 NOTCH1	2.41e-03	1074	95	10	C0006142
Disease	chronic widespread pain	DIP2B SRSF8	2.48e-03	23	95	2	EFO_0010099
Disease	acute myeloid leukemia (is_implicated_in)	ASXL1 ABL1 FANCA	2.55e-03	84	95	3	DOID:9119 (is_implicated_in)
Disease	colon adenocarcinoma (is_marker_for)	EEF2 NOS2	2.93e-03	25	95	2	DOID:234 (is_marker_for)
Disease	glycerol measurement	PCLO SIPA1L2	3.17e-03	26	95	2	EFO_0010115

Protein segments in the cluster

Peptide	Gene	Start	Entry
DREEEQHRMLSRASG	AHRR	376	A9YTQ3
GAEALIMQARSAHRD	ARMC6	456	Q6NXE6
IMQARSAHRDCEDVA	ARMC6	461	Q6NXE6
RLEENIHDAESALRM	CCDC171	1121	Q6TFL3
DVDMDAAAEATRLHQ	ARHGEF11	636	O15085
EMELAAVRTASEDHR	AMOTL1	561	Q8IY63
LRDDAAMRAHAAALG	ADCK5	406	Q3MIX3
HRRGAMEFATEEALA	ATP8B3	671	O60423
RERLADGEFTHEMQV	ASXL1	321	Q8IXJ9
SEELENDREGRAMHS	ALPK1	626	Q96QP1
IRALMLAGADVHARD	ANKRD33B	206	A6NCL7
LDAMDDLDSVRHARR	NWD1	436	Q149M9
MARVFADVHSRASRD	PCDH17	1096	O14917
LALMESRHDSENAER	ITPR3	2001	Q14573
HEARTLLMENAERVG	INTS13	141	Q9NVM9
MGDVLSTHLDDARRQ	NIBAN2	1	Q96TA1
RDSAQCAAIAERLMH	NUDCD1	371	Q96RS6
ELEQLSRMVHRAGDE	ZFYVE28	341	Q9HCC9
EAGERAAREILHAMG	MAOB	441	P27338
RHVERREAEAAMRNG	CYP27B1	266	O15528
VCGDVRMARDVAHTL	NOS2	1081	P35228
RALDGMSALHAAAAR	ESPNL	201	Q6ZVH7
IRNRATDLDARMHDG	NOTCH1	1981	P46531
AMEDEANRADVGHRQ	MAGEE1	936	Q9HCI5
ANIREGLSIMHEARE	KIAA1671	1416	Q9BY89
AIMESRHDSENAERI	ITPR1	2106	Q14643
MRAEARAERAEGHLS	SLC2A7	256	Q6PXP3
EAGEARRHFQLTVME	HMCN2	3486	Q8NDA2
RLHEMDRQVAAVREG	HERC1	4691	Q15751
VDRAIEGAQRAAAMA	JPH1	356	Q9HDC5
ELRQAAEMEELHRSS	PCLO	1841	Q9Y6V0
DAAQQEAKHREAEMR	PDCD5	26	O14737
THQAREACEMRTEAR	KATNAL2	11	Q8IYT4
AVMRALDDMDHEGRD	FGD5	921	Q6ZNL6
LMVSGRRHNADDIVA	DIP2B	816	Q9P265
NAHLGIEQSRRDDME	CSNK1A1L	191	Q8N752
AAEAARMGRRIVELH	nan	96	B2RBV5
ARQRGHEAEESRVML	OSBP	666	P22059
DLFDELVAHEVARMR	SBF1	441	O95248
RHEVTAVFAADAMAR	ILVBL	96	A1L0T0
RLHTIVRGEDEAAMV	GNE	71	Q9Y223
MEHGSIITQARREDA	CTDSP2	1	O14595
AAIREEAFLHVAVDM	FANCA	1346	O15360
SIQEELRHMADGARE	GON4L	926	Q3T8J9
RRAAEHRDTTDVPEM	ABL1	536	P00519
LMEEAERIAREEHGS	ELP3	501	Q9H9T3
AAAAAREARMAEVAR	EID2	96	Q8N6I1
MVDLSHVSDAVARRA	DPEP2	256	Q9H4A9
ALCEENMRGVRFDVH	EEF2	691	P13639
DHALIARCNMEEAVR	EML6	356	Q6ZMW3
DLHIDGRRVDMAAFV	CELSR3	1696	Q9NYQ7
DQTLREREAGTAMHR	BBS1	436	Q8NFJ9
LVEDFRALHQAAEDM	FADS3	111	Q9Y5Q0
GVDRMRLERHLSAED	DMTN	361	Q08495
ERDQALAQLRAHMAD	CCDC153	136	Q494R4
DMRQRHATALEELSE	MYH10	1196	P35580
HRGDAAVRDELMAAV	PSMD6	31	Q15008
RRELAEAMAAQHTAE	NUMA1	786	Q14980
RAVRNPDDLEARSHM	ADHFE1	296	Q8IWW8
VVAIHREMAAAAARI	FES	241	P07332
RAAAALMQDRHTAAG	RIN1	366	Q13671
EASARLDIHQAMASE	RPGRIP1	696	Q96KN7
IAHLAQIEDDRAAMV	SMCHD1	1726	A6NHR9
RHASREEAELVQQMA	TMEM120B	66	A0PK00
QADIMISFVRGDHRD	MMP1	156	P03956
MEERLQHSERARQGA	RUFY1	501	Q96T51
NAHLGIEQSRRDDME	CSNK1A1	191	P48729
RERVASAREALDHMV	PLIN3	391	O60664
MADDTVAELDRHLAV	MRRF	241	Q96E11
AREREDTMEASRHPE	SIPA1L2	1166	Q9P2F8
DQSAALHRRVAAMRE	SIKE1	31	Q9BRV8
RRDLEEATLQHEAMV	MYH3	1176	P11055
HFERVSLDEDNDRLM	SEZ6L2	391	Q6UXD5
AQMLREAAEAGAEAR	SCRIB	1401	Q14160
AERSLREHMGNVVEA	HYPK	101	Q9NX55
RFHDRRDAQDAEAAM	SRSF8	61	Q9BRL6
AIDRAIEAVHNTAMR	NCKIPSD	66	Q9NZQ3
EAVDGVRFIADHMRS	CHRNB2	426	P17787
ENLVEEIRARVMASH	ABTB2	236	Q8N961
RVESHFDLELRAAVM	PRPF8	676	Q6P2Q9
SMCREIGENHEAAAR	SPG11	2226	Q96JI7
EDPVRRNASIHASMD	PLPPR4	426	Q7Z2D5
RGRSMQALAEEDLQH	TTBK1	596	Q5TCY1
AMDAQATHLARLEES	RIBC1	191	Q8N443
AGAQMQRDIEREAHR	MISP3	61	Q96FF7
HMDRIGAIRDNLSET	RNF19A	521	Q9NV58
ERRAMQAALDSVVCH	TRAPPC14	421	Q8WVR3
ATIAHNIREERMENG	SAGE1	106	Q9NXZ1
SNHIGRMAVAAREGD	MRPL2	166	Q5T653
EAALEGAVRALHEDM	SMTNL2	21	Q2TAL5
IQADGRDLNRMHEAT	USP28	116	Q96RU2
DGSHRLGDAQEMRAV	VAT1L	31	Q9HCJ6
RAHAREANDSGETMR	VSIG4	321	Q9Y279
VASMEEARRRQHEAE	PLEC	2686	Q15149
RAFAARMAEIGEHVA	CAD	516	P27708
DLQGRTALHDAAMAD	UACA	131	Q9BZF9
ACDREFAVASRMVEH	ZNF648	396	Q5T619
RQEEMALSVVDAHVR	TRIM23	301	P36406
HDNRMADAIILAIAG	SEC31A	591	O94979
HIRDVAAIVGESMAA	VWA7	486	Q9Y334
LDRLRAHASAMGDED	WWC3	496	Q9ULE0
GAETEAMLQRHIDRV	KIAA1522	226	Q9P206
DARMLGNGEDHRRAA	EXD3	651	Q8N9H8
ASELVVMGDHDAARR	MYOM3	461	Q5VTT5