Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	VPS72 RSF1 SMARCA2 CHD4 FANCM TOP2A TOP2B	1.99e-06	127	92	7	GO:0008094
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	VPS72 RSF1 SMARCA2 CHD4	2.48e-05	37	92	4	GO:0140658
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	VPS72 RSF1 SMARCA2 CHD4 FANCM TOP2A TOP2B PRIMPOL	2.84e-05	262	92	8	GO:0140097
GeneOntologyMolecularFunction	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	TOP2A TOP2B	1.25e-04	4	92	2	GO:0003918
GeneOntologyMolecularFunction	myosin light chain kinase activity	MYLK MYLK2	1.25e-04	4	92	2	GO:0004687
GeneOntologyMolecularFunction	histone binding	VPS72 SUPT6H RSF1 SMARCA2 CHD4 TAF1 SSRP1	2.25e-04	265	92	7	GO:0042393
GeneOntologyMolecularFunction	ATP-dependent activity	VPS72 MYO10 RSF1 SMARCA2 ATP9B CHD4 FANCM TOP2A TOP2B DDX10	5.26e-04	614	92	10	GO:0140657
GeneOntologyMolecularFunction	DNA topoisomerase activity	TOP2A TOP2B	5.77e-04	8	92	2	GO:0003916
GeneOntologyMolecularFunction	chromatin binding	SUPT6H SMARCA2 CHD4 TAF1 SSRP1 FANCM NCAPH TOP2A TOP2B PRIMPOL BAHCC1	5.82e-04	739	92	11	GO:0003682
GeneOntologyMolecularFunction	phosphatidylinositol-4-phosphate binding	OSBP WASHC2C WASHC2A	6.05e-04	36	92	3	GO:0070273
GeneOntologyMolecularFunction	phosphatidylinositol binding	PITPNM2 OSBP WASHC2C MYO10 SNX21 WASHC2A SNX2	6.46e-04	316	92	7	GO:0035091
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	EEF1B2 EEF1D RAB3GAP1 DOCK9 DOCK10 ARHGEF10L	6.99e-04	231	92	6	GO:0005085
GeneOntologyMolecularFunction	small GTPase binding	DMXL2 RAB3GAP1 DOCK9 DOCK10 IPO4 WASF1 CDC42EP1	7.08e-04	321	92	7	GO:0031267
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	VPS72 RSF1 XRN1 SMARCA2 CHD4 FANCM TOP2A TOP2B PRIMPOL DDX10	7.68e-04	645	92	10	GO:0140640
GeneOntologyMolecularFunction	retromer complex binding	WASHC2C WASHC2A	9.22e-04	10	92	2	GO:1905394
GeneOntologyMolecularFunction	phosphatidylinositol transfer activity	PITPNM2 PITPNM3	1.12e-03	11	92	2	GO:0008526
GeneOntologyMolecularFunction	GTPase binding	DMXL2 RAB3GAP1 DOCK9 DOCK10 IPO4 WASF1 CDC42EP1	1.38e-03	360	92	7	GO:0051020
GeneOntologyMolecularFunction	phosphatidylinositol-3-phosphate binding	WASHC2C SNX21 WASHC2A	1.41e-03	48	92	3	GO:0032266
GeneOntologyMolecularFunction	phosphatidylinositol-3,4,5-trisphosphate binding	WASHC2C MYO10 WASHC2A	1.50e-03	49	92	3	GO:0005547
GeneOntologyMolecularFunction	phosphatidylinositol phosphate binding	OSBP WASHC2C MYO10 SNX21 WASHC2A	2.28e-03	199	92	5	GO:1901981
GeneOntologyMolecularFunction	lipid transfer activity	PITPNM2 OSBP PITPNM3	2.31e-03	57	92	3	GO:0120013
GeneOntologyMolecularFunction	basal RNA polymerase II transcription machinery binding	CTR9 UVSSA TAF1	3.51e-03	66	92	3	GO:0001099
GeneOntologyMolecularFunction	basal transcription machinery binding	CTR9 UVSSA TAF1	3.51e-03	66	92	3	GO:0001098
GeneOntologyMolecularFunction	translation elongation factor activity	EEF1B2 EEF1D	3.78e-03	20	92	2	GO:0003746
GeneOntologyBiologicalProcess	positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	TOP2A TOP2B	1.88e-05	2	90	2	GO:0045870
GeneOntologyBiologicalProcess	resolution of meiotic recombination intermediates	FANCM TOP2A TOP2B	6.25e-05	18	90	3	GO:0000712
GeneOntologyBiologicalProcess	maturation of SSU-rRNA	BMS1 KRI1 NOL7 MPHOSPH10	9.75e-05	55	90	4	GO:0030490
GeneOntologyBiologicalProcess	ribosomal small subunit biogenesis	BMS1 KRI1 NOL7 LTV1 MPHOSPH10	1.11e-04	108	90	5	GO:0042274
GeneOntologyBiologicalProcess	ribosome biogenesis	BMS1 KRI1 NOL7 LTV1 MPHOSPH10 IPO4 ZNHIT3 DDX10	1.11e-04	336	90	8	GO:0042254
GeneOntologyBiologicalProcess	female meiosis chromosome separation	NCAPH TOP2A	1.12e-04	4	90	2	GO:0051309
GeneOntologyBiologicalProcess	rRNA metabolic process	BMS1 XRN1 KRI1 NOL7 MPHOSPH10 ZNHIT3 DDX10	2.02e-04	275	90	7	GO:0016072
GeneOntologyBiologicalProcess	DNA recombination	HROB VPS72 SUPT6H CHD4 SPIDR FANCM TOP2A TOP2B	2.07e-04	368	90	8	GO:0006310
GeneOntologyBiologicalProcess	cellular response to abiotic stimulus	EEF1D COPS9 RIPOR2 MYLK VPS13A PBK TAF1 SPIDR	2.18e-04	371	90	8	GO:0071214
GeneOntologyBiologicalProcess	cellular response to environmental stimulus	EEF1D COPS9 RIPOR2 MYLK VPS13A PBK TAF1 SPIDR	2.18e-04	371	90	8	GO:0104004
GeneOntologyCellularComponent	eukaryotic translation elongation factor 1 complex	EEF1B2 EEF1D	1.09e-04	4	90	2	GO:0005853
GeneOntologyCellularComponent	preribosome	BMS1 KRI1 NOL7 LTV1 MPHOSPH10	1.34e-04	114	90	5	GO:0030684
GeneOntologyCellularComponent	90S preribosome	BMS1 KRI1 MPHOSPH10	2.60e-04	29	90	3	GO:0030686
Domain	DNA_topoisoIV	TOP2A TOP2B	2.35e-05	2	91	2	PF00521
Domain	EF1_GNE	EEF1B2 EEF1D	2.35e-05	2	91	2	PF00736
Domain	Transl_elong_EF1B_B/D_CS	EEF1B2 EEF1D	2.35e-05	2	91	2	IPR001326
Domain	Topo_IIA_A/C_ab	TOP2A TOP2B	2.35e-05	2	91	2	IPR013758
Domain	Topo_IIA_A_a	TOP2A TOP2B	2.35e-05	2	91	2	IPR013757
Domain	Topo_IIA_cen_dom	TOP2A TOP2B	2.35e-05	2	91	2	IPR013759
Domain	-	TOP2A TOP2B	2.35e-05	2	91	2	3.40.50.670
Domain	DTHCT	TOP2A TOP2B	2.35e-05	2	91	2	IPR012542
Domain	TOP4c	TOP2A TOP2B	2.35e-05	2	91	2	SM00434
Domain	TOP2c	TOP2A TOP2B	2.35e-05	2	91	2	SM00433
Domain	Topo_IIA-like_dom	TOP2A TOP2B	2.35e-05	2	91	2	IPR013760
Domain	EF1_GNE	EEF1B2 EEF1D	2.35e-05	2	91	2	SM00888
Domain	Topo_IIA_bsu_dom2	TOP2A TOP2B	2.35e-05	2	91	2	IPR013506
Domain	DTHCT	TOP2A TOP2B	2.35e-05	2	91	2	PF08070
Domain	EF1BD_1	EEF1B2 EEF1D	2.35e-05	2	91	2	PS00824
Domain	EF1BD_2	EEF1B2 EEF1D	2.35e-05	2	91	2	PS00825
Domain	DNA_gyraseB	TOP2A TOP2B	2.35e-05	2	91	2	PF00204
Domain	-	TOP2A TOP2B	2.35e-05	2	91	2	1.10.268.10
Domain	EF-1_beta_acid	EEF1B2 EEF1D	2.35e-05	2	91	2	PF10587
Domain	TOPRIM_C	TOP2A TOP2B	2.35e-05	2	91	2	IPR031660
Domain	TOPRIM_C	TOP2A TOP2B	2.35e-05	2	91	2	PF16898
Domain	-	TOP2A TOP2B	2.35e-05	2	91	2	3.90.199.10
Domain	TopoIIA_CS	TOP2A TOP2B	2.35e-05	2	91	2	IPR018522
Domain	EF-1_beta_acid	EEF1B2 EEF1D	2.35e-05	2	91	2	SM01182
Domain	EF1B_bsu/dsu_GNE	EEF1B2 EEF1D	2.35e-05	2	91	2	IPR014038
Domain	EF-1_beta_acid_region_euk	EEF1B2 EEF1D	2.35e-05	2	91	2	IPR018940
Domain	FAM21	WASHC2C WASHC2A	2.35e-05	2	91	2	IPR027308
Domain	Topo_IIA_A/C	TOP2A TOP2B	2.35e-05	2	91	2	IPR002205
Domain	Topo_IIA	TOP2A TOP2B	2.35e-05	2	91	2	IPR001241
Domain	TOPOISOMERASE_II	TOP2A TOP2B	2.35e-05	2	91	2	PS00177
Domain	-	TOP2A TOP2B	7.02e-05	3	91	2	3.30.1360.40
Domain	Transl_elong_EF1B/ribosomal_S6	EEF1B2 EEF1D	7.02e-05	3	91	2	IPR014717
Domain	-	EEF1B2 EEF1D	7.02e-05	3	91	2	3.30.70.60
Domain	Arg_repress_C-like	TOP2A TOP2B	7.02e-05	3	91	2	IPR024946
Domain	FAM21/CAPZIP	WASHC2C WASHC2A	7.02e-05	3	91	2	IPR029341
Domain	CAP-ZIP_m	WASHC2C WASHC2A	7.02e-05	3	91	2	PF15255
Domain	Toprim_domain	TOP2A TOP2B	1.40e-04	4	91	2	IPR006171
Domain	Toprim	TOP2A TOP2B	1.40e-04	4	91	2	PF01751
Domain	TOPRIM	TOP2A TOP2B	1.40e-04	4	91	2	PS50880
Domain	-	PITPNM2 PHOSPHO1 PITPNM3 ATP9B	2.68e-04	64	91	4	3.40.50.1000
Domain	DUF3398	DOCK9 DOCK10	3.48e-04	6	91	2	PF11878
Domain	LNS2	PITPNM2 PITPNM3	3.48e-04	6	91	2	PF08235
Domain	LNS2	PITPNM2 PITPNM3	3.48e-04	6	91	2	IPR013209
Domain	PI_transfer	PITPNM2 PITPNM3	3.48e-04	6	91	2	IPR001666
Domain	LNS2	PITPNM2 PITPNM3	3.48e-04	6	91	2	SM00775
Domain	DDHD	PITPNM2 PITPNM3	3.48e-04	6	91	2	PF02862
Domain	DDHD	PITPNM2 PITPNM3	3.48e-04	6	91	2	PS51043
Domain	LNS2/PITP	PITPNM2 PITPNM3	3.48e-04	6	91	2	IPR031315
Domain	DDHD_dom	PITPNM2 PITPNM3	3.48e-04	6	91	2	IPR004177
Domain	DOCK_C/D_N	DOCK9 DOCK10	3.48e-04	6	91	2	IPR021816
Domain	DDHD	PITPNM2 PITPNM3	3.48e-04	6	91	2	SM01127
Domain	HAD-like_dom	PITPNM2 PHOSPHO1 PITPNM3 ATP9B	5.99e-04	79	91	4	IPR023214
Domain	RuvA_2-like	SUPT6H FANCM	8.27e-04	9	91	2	IPR010994
Domain	DOCK_C	DOCK9 DOCK10	1.25e-03	11	91	2	IPR010703
Domain	DHR-1_domain	DOCK9 DOCK10	1.25e-03	11	91	2	IPR027007
Domain	DHR_2	DOCK9 DOCK10	1.25e-03	11	91	2	PS51651
Domain	DHR_1	DOCK9 DOCK10	1.25e-03	11	91	2	PS51650
Domain	DOCK-C2	DOCK9 DOCK10	1.25e-03	11	91	2	PF14429
Domain	DHR-2	DOCK9 DOCK10	1.25e-03	11	91	2	IPR027357
Domain	DHR-2	DOCK9 DOCK10	1.25e-03	11	91	2	PF06920
Domain	DOCK	DOCK9 DOCK10	1.25e-03	11	91	2	IPR026791
Domain	Helicase_C	SMARCA2 CHD4 FANCM DDX10	1.86e-03	107	91	4	PF00271
Domain	HELICc	SMARCA2 CHD4 FANCM DDX10	1.86e-03	107	91	4	SM00490
Domain	Helicase_C	SMARCA2 CHD4 FANCM DDX10	1.92e-03	108	91	4	IPR001650
Domain	HELICASE_CTER	SMARCA2 CHD4 FANCM DDX10	1.99e-03	109	91	4	PS51194
Domain	HELICASE_ATP_BIND_1	SMARCA2 CHD4 FANCM DDX10	1.99e-03	109	91	4	PS51192
Domain	DEXDc	SMARCA2 CHD4 FANCM DDX10	1.99e-03	109	91	4	SM00487
Domain	Helicase_ATP-bd	SMARCA2 CHD4 FANCM DDX10	2.05e-03	110	91	4	IPR014001
Domain	-	OSBP MYO10 DOCK9 DOCK10 SSRP1 ARHGEF10L FRMD3	2.99e-03	391	91	7	2.30.29.30
Domain	HATPase_c	TOP2A TOP2B	3.41e-03	18	91	2	SM00387
Domain	HATPase_c	TOP2A TOP2B	3.80e-03	19	91	2	PF02518
Domain	-	TOP2A TOP2B	4.21e-03	20	91	2	3.30.565.10
Domain	-	TOP2A TOP2B	4.64e-03	21	91	2	3.30.230.10
Domain	HATPase_C	TOP2A TOP2B	4.64e-03	21	91	2	IPR003594
Domain	PH_dom-like	OSBP MYO10 DOCK9 DOCK10 SSRP1 ARHGEF10L FRMD3	4.78e-03	426	91	7	IPR011993
Pathway	REACTOME_SYNTHESIS_OF_PI	PITPNM2 PITPNM3	2.07e-04	5	65	2	MM14587
Pathway	REACTOME_EUKARYOTIC_TRANSLATION_ELONGATION	EEF1B2 EEF1D	2.07e-04	5	65	2	MM14603
Pathway	REACTOME_SYNTHESIS_OF_PI	PITPNM2 PITPNM3	2.07e-04	5	65	2	M26962
Pathway	REACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS	SUPT6H CTR9 TAF1 SSRP1	5.25e-04	81	65	4	M865
Pathway	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	MYLK WASF1 MYLK2	5.51e-04	35	65	3	M16801
Pathway	REACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS	SUPT6H CTR9 TAF1 SSRP1	5.76e-04	83	65	4	MM15314
Pathway	REACTOME_RAC3_GTPASE_CYCLE	DOCK10 WASF1 ERBIN CDC42EP1	8.84e-04	93	65	4	MM15609
Pathway	REACTOME_RAC3_GTPASE_CYCLE	DOCK10 WASF1 ERBIN CDC42EP1	9.20e-04	94	65	4	M41818
Pathway	BIOCARTA_DNAFRAGMENT_PATHWAY	TOP2A TOP2B	9.20e-04	10	65	2	M7239
Pathway	BIOCARTA_DNAFRAGMENT_PATHWAY	TOP2A TOP2B	1.12e-03	11	65	2	MM1349
Pathway	SIG_CHEMOTAXIS	MYLK WASF1 MYLK2	1.16e-03	45	65	3	M5193
Pathway	REACTOME_RAC1_GTPASE_CYCLE	DOCK9 DOCK10 WASF1 ERBIN CDC42EP1	1.26e-03	175	65	5	MM15599
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DMXL2 FRAS1 RAB3GAP1 SLC4A1AP CEBPZ CCDC47 SUPT6H CTR9 CWC15 ECD BMS1 CCSER2 VPS13A RCN2 KRI1 AKAP11 LTV1 CTNNA1 HNRNPUL1 SSRP1 IPO4 SEC63 WASHC2A ERBIN PBXIP1 SNX2 TOP2B PPM1G DDX10 CDC42EP1	7.34e-19	1487	92	30	33957083
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	EEF1B2 OSBP EEF1D SLC4A1AP SUPT6H RSF1 BMS1 LTV1 CHD4 MPHOSPH10 SSRP1 TOP2A	1.96e-14	163	92	12	22113938
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	EEF1B2 EEF1D RBM25 ZBTB33 VPS72 SLC4A1AP CEBPZ CWC15 RSF1 ZNF638 KRI1 NOL7 CHD4 MPHOSPH10 TAF1 HNRNPUL1 SSRP1 FANCM TOP2A TOP2B DDX10	5.84e-14	954	92	21	36373674
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	EEF1D RBM25 SLC4A1AP CEBPZ SUPT6H CTR9 BMS1 ZNF638 KRI1 NOL7 CHD4 MPHOSPH10 HNRNPUL1 SSRP1 IPO4 SEC63 ERBIN TOP2A TOP2B PPM1G DDX10	1.17e-13	989	92	21	36424410
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	ZBTB33 CEBPZ ZNF638 KRI1 CHD4 MPHOSPH10 HNRNPUL1 TOP2A TOP2B PPM1G DDX10	2.27e-13	148	92	11	32538781
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	EEF1B2 EEF1D RBM25 CEBPZ CCDC47 SUPT6H CTR9 RGS22 BMS1 RCN2 KRI1 NOL7 APLP2 LTV1 CHD4 HNRNPUL1 SSRP1 IPO4 SEC63 NCAPH TOP2A SNX2 TOP2B DDX10	2.30e-13	1425	92	24	30948266
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	EEF1B2 EEF1D RBM25 CEBPZ CCDC47 CTR9 CWC15 BMS1 SMARCA2 KRI1 NOL7 LTV1 CHD4 MPHOSPH10 HNRNPUL1 SSRP1 IPO4 SEC63 NCAPH TOP2A SNX2 TOP2B DDX10	3.87e-13	1318	92	23	30463901
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RBM25 CEBPZ SUPT6H RSF1 BMS1 XRN1 SMARCA2 ZNF638 KRI1 CUL9 CHD4 MPHOSPH10 CTNNA1 HNRNPUL1 IPO4 PPM1G DDX10	1.39e-12	653	92	17	22586326
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	SUPT6H CTR9 CWC15 KRI1 APLP2 EGFLAM LTV1 MPHOSPH10 SSRP1 TOP2A TOP2B PPM1G	3.34e-12	251	92	12	28077445
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	EEF1B2 EEF1D RAB3GAP1 CEBPZ CCDC47 CTR9 RSF1 BMS1 XRN1 SMARCA2 DOCK10 ZNF638 LTV1 CHD4 HNRNPUL1 SSRP1 IPO4 NCAPH ERBIN TOP2A TOP2B DDX10	5.51e-12	1353	92	22	29467282
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	EEF1B2 OSBP EEF1D FRAS1 RBM25 VPS72 SUPT6H CTR9 CFDP1 RSF1 RCN2 KRI1 SSRP1 IPO4 SEC63 PPM1G	1.67e-11	653	92	16	33742100
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	EEF1B2 OSBP RBM25 PDE4C WASHC2C SLC4A1AP CTR9 SMARCA2 ZNF638 CHD4 CTNNA1 HNRNPUL1 SSRP1 ERBIN TOP2A SNX2 TOP2B	2.02e-11	774	92	17	15302935
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EEF1B2 STRN VPS72 SLC4A1AP CEBPZ CCDC47 SUPT6H CTR9 BMS1 XRN1 SMARCA2 RCN2 NOL7 APLP2 MPHOSPH10 SSRP1 IPO4 SEC63 ERBIN PBXIP1 MYLK2 DDX10	3.89e-11	1497	92	22	31527615
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	EEF1B2 EEF1D RBM25 CEBPZ CWC15 ECD BMS1 RCN2 ZNF638 KRI1 LTV1 MPHOSPH10 CTNNA1 HNRNPUL1 SSRP1 IPO4 SEC63 NCAPH TOP2A PPM1G	8.76e-11	1257	92	20	36526897
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	EEF1B2 EEF1D RAB3GAP1 CEBPZ CCDC47 ECD BMS1 RCN2 KRI1 CHD4 CTNNA1 HNRNPUL1 SSRP1 IPO4 SEC63 NCAPH ERBIN PBXIP1 TOP2A TOP2B PPM1G	1.35e-10	1440	92	21	30833792
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	EEF1B2 EEF1D RBM25 ZBTB33 CEBPZ ZNF638 CHD4 SSRP1 TOP2A TOP2B DDX10	1.62e-10	271	92	11	32433965
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	ZBTB33 CFDP1 BMS1 ZNF638 KRI1 TAF1 SSRP1 TOP2A TOP2B PPM1G DDX10	2.56e-10	283	92	11	30585729
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EEF1B2 ZBTB33 WASHC2C CWC15 ECD CFDP1 RSF1 XRN1 ZNF638 LTV1 CHD4 HNRNPUL1 NCAPH ERBIN TOP2A TOP2B DDX10	3.64e-10	934	92	17	33916271
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	EEF1B2 EEF1D SLC4A1AP CEBPZ CCDC47 SUPT6H CTR9 ECD PBK ZNF638 KRI1 LTV1 CHD4 CTNNA1 HNRNPUL1 SSRP1 NCAPH TOP2A TOP2B PPM1G	6.90e-10	1415	92	20	28515276
Pubmed	Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.	RBM25 MYLK CEBPZ CWC15 BMS1 MPHOSPH10 CTNNA1 SSRP1 TOP2A PPM1G DDX10 CDC42EP1	7.84e-10	403	92	12	35253629
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	EEF1B2 EEF1D STRN MYLK CEBPZ CCDC47 CTR9 ECD RSF1 VPS13A XRN1 CHD4 MPHOSPH10 SSRP1 NCAPH ERBIN TOP2A TOP2B MYLK2 BAHCC1	9.55e-10	1442	92	20	35575683
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	OSBP EEF1D RAB3GAP1 VIPAS39 VPS72 CCDC47 CWC15 PBK APLP2 LTV1 HNRNPUL1 SSRP1 ERBIN PBXIP1 SNX2 YIPF3 CDC42EP1	1.13e-09	1007	92	17	34597346
Pubmed	Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.	RBM25 CHD4 CTNNA1 SSRP1 FANCM TOP2B	1.21e-09	41	92	6	15561718
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	RBM25 CEBPZ BMS1 XRN1 ZNF638 KRI1 MPHOSPH10 SSRP1 TOP2A TOP2B DDX10	1.37e-09	332	92	11	25693804
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SLC4A1AP SUPT6H CTR9 RSF1 ZNF638 CHD4 HNRNPUL1 SSRP1 TOP2A TOP2B	1.38e-09	251	92	10	31076518
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	STRN DOCK9 CCSER2 ZNF638 KRI1 AKAP11 LTV1 TOP2A	1.60e-09	125	92	8	29467281
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	VPS72 CEBPZ SUPT6H CTR9 CCSER2 SMARCA2 CHD4 MPHOSPH10 HNRNPUL1 SSRP1 TOP2A TOP2B	2.11e-09	440	92	12	34244565
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	EEF1B2 ZBTB33 CEBPZ RSF1 BMS1 RCN2 KRI1 CHD4 MPHOSPH10 PPM1G DDX10	2.31e-09	349	92	11	25665578
Pubmed	Human transcription factor protein interaction networks.	EEF1D RBM25 ZBTB33 VPS72 CFDP1 BMS1 XRN1 SMARCA2 RCN2 ZNF638 KRI1 CUL9 LTV1 TAF1 HNRNPUL1 WASHC2A ERBIN PPM1G DDX10	5.34e-09	1429	92	19	35140242
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	RBM25 CEBPZ SUPT6H CTR9 BMS1 SMARCA2 ZNF638 KRI1 CHD4 SSRP1 TOP2A TOP2B DDX10	7.47e-09	605	92	13	28977666
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	RBM25 CTR9 CHD4 CTNNA1 HNRNPUL1 SSRP1 IPO4 TOP2A SNX2 TOP2B PPM1G	9.49e-09	400	92	11	35013556
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	VIPAS39 SLC4A1AP CEBPZ CCDC47 CTR9 BMS1 VPS13A RCN2 ZNF638 KRI1 APLP2 CTNNA1 WASF1 ERBIN PPM1G CDC42EP1	1.54e-08	1049	92	16	27880917
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	VIPAS39 ZBTB33 BMS1 VPS13A XRN1 ZNF638 CHD4 HNRNPUL1 IPO4 NCAPH WASF1 ERBIN PPM1G CDC42EP1	1.73e-08	777	92	14	35844135
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	CEBPZ RSF1 BMS1 KRI1 LTV1 CHD4 SSRP1 TOP2A TOP2B DDX10	1.87e-08	330	92	10	33301849
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	CEBPZ SUPT6H CWC15 RSF1 ZNF638 CTNNA1 SSRP1 NCAPH HYDIN TOP2A TOP2B	4.81e-08	469	92	11	27634302
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	PITPNM2 EEF1B2 OSBP EEF1D DMXL2 STRN RAB3GAP1 VIPAS39 WASHC2C DOCK9 XRN1 PITPNM3 WASHC2A WASF1 ERBIN PPM1G	4.81e-08	1139	92	16	36417873
Pubmed	Intrinsically Disordered Protein TEX264 Mediates ER-phagy.	RAB3GAP1 RBM25 CTR9 ZNF638 AKAP11 HNRNPUL1 YIPF3	6.14e-08	131	92	7	31006538
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	EEF1B2 EEF1D RBM25 SUPT6H CTR9 CFDP1 RSF1 SMARCA2 CHD4 TAF1 SSRP1 NCAPH TOP2A TOP2B PPM1G	6.81e-08	1014	92	15	32416067
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	EEF1B2 EEF1D RBM25 CEBPZ SUPT6H ZNF638 NOL7 CHD4 CTNNA1 HNRNPUL1 SSRP1 TOP2A SNX2 TOP2B DDX10	7.73e-08	1024	92	15	24711643
Pubmed	Directed proteomic analysis of the human nucleolus.	CEBPZ BMS1 NOL7 CHD4 MPHOSPH10 TOP2A TOP2B DDX10	8.66e-08	208	92	8	11790298
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	EEF1B2 EEF1D ZBTB33 CCDC47 CWC15 CFDP1 BMS1 SMARCA2 CHD4 CTNNA1 HNRNPUL1 SSRP1 IPO4 NCAPH ERBIN TOP2A PPM1G	1.00e-07	1367	92	17	32687490
Pubmed	Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.	CTR9 SMARCA2 CHD4 TOP2A TOP2B	1.03e-07	43	92	5	26030138
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	CEBPZ BMS1 XRN1 KRI1 NOL7 LTV1 CHD4 MPHOSPH10 HNRNPUL1 SSRP1 TOP2A TOP2B DDX10	1.05e-07	759	92	13	35915203
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	ZBTB33 PEG3 RSF1 ZNF638 TOP2A TOP2B	1.15e-07	86	92	6	37253089
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FRAS1 RIPOR2 WASHC2C MYO10 DOCK9 PEG3 DOCK10 CUL9 WASHC2A ERBIN	1.33e-07	407	92	10	12693553
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	RBM25 ZBTB33 VPS72 CEBPZ XRN1 TAF1 SSRP1 NCAPH ERBIN TOP2A SNX2	2.33e-07	549	92	11	38280479
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	RBM25 ZBTB33 VPS72 RSF1 ZNF316 XRN1 SMARCA2 RCN2 CUL9 CHD4 TAF1 SSRP1 TOP2A BAHCC1 CDC42EP1	2.33e-07	1116	92	15	31753913
Pubmed	FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.	RBM25 KRI1 NOL7 CHD4 MPHOSPH10 HNRNPUL1 SSRP1 TOP2A	3.32e-07	248	92	8	27926873
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	RSF1 SMARCA2 CHD4 SSRP1 TOP2A TOP2B	3.38e-07	103	92	6	32744500
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	EEF1B2 EEF1D RAB3GAP1 CEBPZ CCDC47 SMARCA2 CHD4 SSRP1 IPO4 NCAPH TOP2A TOP2B	3.57e-07	704	92	12	29955894
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	EEF1B2 EEF1D RBM25 WASHC2C CEBPZ BMS1 ZNF638 KRI1 CHD4 MPHOSPH10 SSRP1 TOP2A TOP2B	3.67e-07	847	92	13	35850772
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	EEF1B2 EEF1D RBM25 SLC4A1AP SUPT6H ECD PBK SMARCA2 LTV1 CHD4 SSRP1 NCAPH PPM1G	3.67e-07	847	92	13	35235311
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	EEF1D ZBTB33 CFDP1 BMS1 CUL9 CHD4 SPIDR NCAPH WASF1 TOP2A SNX2 TOP2B ANKRD26P1	4.19e-07	857	92	13	25609649
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	VPS72 CWC15 ECD BMS1 NOL7 CHD4 SSRP1 DDX10	4.61e-07	259	92	8	30404004
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	RBM25 CEBPZ CTR9 CWC15 BMS1 KRI1 NOL7 CHD4 HNRNPUL1 SSRP1 TOP2A DDX10	5.31e-07	731	92	12	29298432
Pubmed	Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.	EEF1B2 STRN RBM25 CHD4 SSRP1 TOP2A TOP2B	5.35e-07	180	92	7	30110629
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	VIPAS39 ZBTB33 CEBPZ CCDC47 CWC15 XRN1 RCN2 ZNF638 SEC63 WASHC2A ERBIN YIPF3	5.47e-07	733	92	12	34672954
Pubmed	Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.	RBM25 SUPT6H CWC15 BMS1 CHD4 SSRP1 IPO4	5.76e-07	182	92	7	26527279
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	PITPNM2 HROB MYO10 CTR9 ECD XRN1 LTV1 SNX21 TYSND1 SSRP1 WASHC2A ERBIN ZNHIT3 CDC42EP1	5.91e-07	1038	92	14	26673895
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	CEBPZ BMS1 ZNF638 KRI1 NOL7 CHD4 MPHOSPH10 SSRP1 TOP2A DDX10	6.35e-07	483	92	10	36912080
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	SLC4A1AP CFDP1 RSF1 NOL7 CHD4 TAF1 SSRP1 TOP2A TOP2B PPM1G DDX10	6.37e-07	608	92	11	36089195
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	DMXL2 VIPAS39 WASHC2C CCDC47 VPS13A AKAP11 SEC63 WASHC2A SNX2 YIPF3	9.32e-07	504	92	10	34432599
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	OSBP RAB3GAP1 CCDC47 RSF1 VPS13A SMARCA2 PITPNM3 NOL7 LTV1 MPHOSPH10 WASF1	1.02e-06	638	92	11	31182584
Pubmed	CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism.	WASHC2C ECD LTV1 SSRP1 SEC63 PBXIP1 PPM1G	1.12e-06	201	92	7	34917906
Pubmed	A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.	EEF1B2 EEF1D CWC15 RCN2 CHD4 CTNNA1 HNRNPUL1 SSRP1 TOP2A SNX2 TOP2B PPM1G	1.13e-06	786	92	12	29128334
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	RBM25 RSF1 SMARCA2 RCN2 CHD4 TAF1 SSRP1 TOP2A TOP2B DDX10	1.54e-06	533	92	10	30554943
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	EEF1B2 CTR9 ECD BMS1 XRN1 RCN2 KRI1 APLP2 CTNNA1 IPO4 SEC63 SNX2 PPM1G	1.74e-06	974	92	13	28675297
Pubmed	Nucleolar proteome dynamics.	CEBPZ BMS1 NOL7 CHD4 MPHOSPH10 SSRP1 TOP2A TOP2B DDX10	1.76e-06	419	92	9	15635413
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	STRN WASHC2C CWC15 ECD CCSER2 SMARCA2 RCN2 LTV1 CTNNA1 HNRNPUL1 WASHC2A ZNHIT3 TOP2A TOP2B	2.07e-06	1155	92	14	20360068
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	STRN COPS9 ZBTB33 MYO10 SUPT6H BMS1 SMARCA2 KRI1 CHD4 TYSND1 IPO4 PPM1G DDX10	2.46e-06	1005	92	13	19615732
Pubmed	Genomic analysis of mouse retinal development.	PITPNM2 OSBP RAB3GAP1 VIPAS39 WASHC2C CCDC47 PBK PITPNM3 CUL9 NOL7 WASHC2A NCAPH ERBIN	2.48e-06	1006	92	13	15226823
Pubmed	A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation.	COPS9 RSF1 CHD4 SSRP1	2.53e-06	36	92	4	29089422
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	RBM25 ZBTB33 CCDC47 XRN1 RCN2 LTV1 CTNNA1 SEC63 ERBIN PPM1G CDC42EP1	2.78e-06	708	92	11	39231216
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	EEF1D RBM25 CEBPZ CCDC47 CWC15 PEG3 BMS1 RCN2 KRI1 NOL7 LTV1 CHD4 SSRP1 SEC63 DDX10	3.03e-06	1371	92	15	36244648
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	EEF1B2 EEF1D OTOF KRI1 LTV1 TOP2A TOP2B	3.08e-06	234	92	7	36243803
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	STRN WASHC2C VPS72 SUPT6H CTR9 CUL9 IPO4 CFAP44 WASHC2A PPM1G	3.68e-06	588	92	10	38580884
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	RAB3GAP1 ECD XRN1 AKAP11 LTV1 WASHC2A PPM1G	3.84e-06	242	92	7	34011540
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	EEF1B2 EEF1D CCDC47 RCN2 LTV1 CHD4 HNRNPUL1 SSRP1 TOP2A TOP2B	4.46e-06	601	92	10	33658012
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	EEF1B2 STRN SLC4A1AP CWC15 BMS1 SMARCA2 MPHOSPH10 WASHC2A ERBIN	4.64e-06	472	92	9	38943005
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	EEF1B2 EEF1D RBM25 CEBPZ XRN1 SMARCA2 RCN2 CHD4 MPHOSPH10 CTNNA1 HNRNPUL1 SSRP1 ERBIN TOP2A	5.01e-06	1247	92	14	27684187
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DMXL2 RBM25 SUPT6H BMS1 RCN2 ZNF638 APLP2 CHD4 HNRNPUL1 SSRP1 SEC63 PBXIP1 TOP2B	5.47e-06	1082	92	13	38697112
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	EEF1B2 OSBP EEF1D RAB3GAP1 CTR9 RCN2 LTV1 CTNNA1 HNRNPUL1 SSRP1 IPO4 WASHC2A NCAPH SNX2 PPM1G	6.20e-06	1455	92	15	22863883
Pubmed	Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.	EEF1B2 EEF1D RBM25 ZNF638 CHD4 TOP2B	6.29e-06	170	92	6	16159877
Pubmed	A novel tumor suppressor role of myosin light chain kinase splice variants through downregulation of the TEAD4/CD44 axis.	MYLK MYLK2	6.92e-06	2	92	2	34000008
Pubmed	DNA topoisomerase II is dispensable for oocyte meiotic resumption but is essential for meiotic chromosome condensation and separation in mice.	TOP2A TOP2B	6.92e-06	2	92	2	24048577
Pubmed	Association of immunophenotype with expression of topoisomerase II α and β in adult acute myeloid leukemia.	TOP2A TOP2B	6.92e-06	2	92	2	32218491
Pubmed	Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).	WASHC2C WASHC2A	6.92e-06	2	92	2	20827171
Pubmed	Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma.	MYLK MYLK2	6.92e-06	2	92	2	18828194
Pubmed	Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively.	TOP2A TOP2B	6.92e-06	2	92	2	1309226
Pubmed	Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.	TOP2A TOP2B	6.92e-06	2	92	2	19222228
Pubmed	Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells.	TOP2A TOP2B	6.92e-06	2	92	2	2555055
Pubmed	Involvement of human topoisomerase II isoforms in HIV-1 reverse transcription.	TOP2A TOP2B	6.92e-06	2	92	2	23399433
Pubmed	Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2.	TOP2A TOP2B	6.92e-06	2	92	2	30169847
Pubmed	Characterization of cDNA encoding the mouse DNA topoisomerase II that can complement the budding yeast top2 mutation.	TOP2A TOP2B	6.92e-06	2	92	2	1331984
Pubmed	Enhanced processing of UVA-irradiated DNA by human topoisomerase II in living cells.	TOP2A TOP2B	6.92e-06	2	92	2	15044480
Pubmed	C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo.	TOP2A TOP2B	6.92e-06	2	92	2	17526531
Pubmed	FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.	WASHC2C WASHC2A	6.92e-06	2	92	2	36717248
Pubmed	Doxorubicin-induced cardiotoxicity is maturation dependent due to the shift from topoisomerase IIα to IIβ in human stem cell derived cardiomyocytes.	TOP2A TOP2B	6.92e-06	2	92	2	31106979
Pubmed	A biochemical analysis of topoisomerase II alpha and beta kinase activity found in HIV-1 infected cells and virus.	TOP2A TOP2B	6.92e-06	2	92	2	16091284
Pubmed	The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues.	TOP2A TOP2B	6.92e-06	2	92	2	9155056
Interaction	POLR1G interactions	VPS72 SLC4A1AP CEBPZ SUPT6H CTR9 CFDP1 RSF1 BMS1 KRI1 MPHOSPH10 TAF1 SNX21 SSRP1 IPO4 TOP2A TOP2B PPM1G DDX10	5.75e-12	489	91	18	int:POLR1G
Interaction	PYHIN1 interactions	SUPT6H CTR9 CWC15 RSF1 RCN2 KRI1 APLP2 EGFLAM LTV1 CHD4 MPHOSPH10 SSRP1 TOP2A TOP2B PPM1G	6.67e-11	358	91	15	int:PYHIN1
Interaction	CSNK2A1 interactions	EEF1B2 OSBP EEF1D STRN VPS72 CCDC82 SLC4A1AP SUPT6H CTR9 ECD CFDP1 RSF1 BMS1 CUL9 LTV1 CHD4 MPHOSPH10 CTNNA1 TAF1 SSRP1 TOP2A	1.19e-09	956	91	21	int:CSNK2A1
Interaction	ZNF330 interactions	SLC4A1AP CEBPZ SUPT6H CTR9 CFDP1 RSF1 BMS1 KRI1 TAF1 SSRP1 IPO4 TOP2A TOP2B PPM1G DDX10	1.40e-09	446	91	15	int:ZNF330
Interaction	SMC5 interactions	EEF1B2 EEF1D RBM25 ZBTB33 VPS72 SLC4A1AP CEBPZ CWC15 RSF1 ZNF638 KRI1 NOL7 CHD4 MPHOSPH10 TAF1 HNRNPUL1 SSRP1 FANCM TOP2A TOP2B DDX10	2.66e-09	1000	91	21	int:SMC5
Interaction	SNRNP40 interactions	RBM25 VPS72 SLC4A1AP CEBPZ SUPT6H CWC15 ECD RSF1 ZNF316 BMS1 KRI1 CUL9 MPHOSPH10 HNRNPUL1 SSRP1 TOP2A TOP2B	3.31e-09	637	91	17	int:SNRNP40
Interaction	DDX23 interactions	RBM25 CEBPZ SUPT6H CTR9 CWC15 BMS1 ZNF638 KRI1 CHD4 MPHOSPH10 TAF1 SSRP1 TOP2A TOP2B DDX10	3.78e-09	480	91	15	int:DDX23
Interaction	SIRT7 interactions	RBM25 CEBPZ SUPT6H RSF1 BMS1 XRN1 SMARCA2 ZNF638 KRI1 CUL9 CHD4 MPHOSPH10 CTNNA1 HNRNPUL1 IPO4 TOP2A PPM1G DDX10	4.99e-09	744	91	18	int:SIRT7
Interaction	CIT interactions	EEF1B2 EEF1D RBM25 VPS72 CEBPZ SUPT6H CTR9 CWC15 RSF1 BMS1 SMARCA2 RCN2 ZNF638 KRI1 NOL7 CHD4 MPHOSPH10 CTNNA1 HNRNPUL1 SSRP1 TOP2A SNX2 TOP2B DDX10	1.68e-08	1450	91	24	int:CIT
Interaction	H2AB2 interactions	CEBPZ BMS1 KRI1 LTV1 MPHOSPH10 SSRP1 PPM1G DDX10	2.86e-08	107	91	8	int:H2AB2
Interaction	EP300 interactions	EEF1B2 OSBP EEF1D FRAS1 STRN RBM25 ZBTB33 VPS72 SUPT6H CTR9 CFDP1 RSF1 SMARCA2 RCN2 KRI1 CHD4 HNRNPUL1 SSRP1 IPO4 SEC63 TOP2A TOP2B PPM1G	4.18e-08	1401	91	23	int:EP300
Interaction	NR2C2 interactions	EEF1B2 EEF1D RBM25 CEBPZ CCDC47 CTR9 CWC15 BMS1 SMARCA2 KRI1 NOL7 LTV1 CHD4 MPHOSPH10 HNRNPUL1 SSRP1 IPO4 SEC63 NCAPH TOP2A SNX2 TOP2B DDX10	4.29e-08	1403	91	23	int:NR2C2
Interaction	RPL31 interactions	EEF1B2 CEBPZ CCDC47 SUPT6H UVSSA BMS1 KRI1 LTV1 CHD4 MPHOSPH10 TAF1 NCAPH TOP2A TOP2B PPM1G DDX10	5.86e-08	680	91	16	int:RPL31
Interaction	PARP1 interactions	RBM25 VPS72 CEBPZ SUPT6H CTR9 ECD RSF1 BMS1 SMARCA2 KRI1 CHD4 MPHOSPH10 CTNNA1 HNRNPUL1 SSRP1 IPO4 NCAPH TOP2A SNX2 TOP2B PPM1G DDX10	6.43e-08	1316	91	22	int:PARP1
Interaction	UTP4 interactions	CEBPZ BMS1 CCSER2 KRI1 NOL7 LTV1 MPHOSPH10 TAF1 PPM1G	7.58e-08	170	91	9	int:UTP4
Interaction	IFI16 interactions	RBM25 SLC4A1AP CEBPZ BMS1 XRN1 RCN2 ZNF638 KRI1 CHD4 MPHOSPH10 HNRNPUL1 SSRP1 TOP2A TOP2B PPM1G DDX10	1.14e-07	714	91	16	int:IFI16
Interaction	CENPA interactions	CEBPZ CCDC47 RSF1 BMS1 SMARCA2 KRI1 TAF1 SSRP1 IPO4 TOP2A TOP2B PPM1G	1.29e-07	377	91	12	int:CENPA
Interaction	E2F4 interactions	RAB3GAP1 RBM25 MYLK CEBPZ CWC15 BMS1 PBK MPHOSPH10 CTNNA1 SSRP1 TOP2A PPM1G DDX10 CDC42EP1	1.34e-07	540	91	14	int:E2F4
Interaction	H1-4 interactions	EEF1D CEBPZ CTR9 RSF1 BMS1 XRN1 ZNF638 KRI1 LTV1 CHD4 MPHOSPH10 HNRNPUL1 NCAPH TOP2B DDX10	2.31e-07	656	91	15	int:H1-4
Interaction	H2BC8 interactions	VPS72 SLC4A1AP CCDC47 CFDP1 RSF1 BMS1 AKAP11 CHD4 SSRP1 IPO4 TOP2A TOP2B PPM1G DDX10	2.93e-07	576	91	14	int:H2BC8
Interaction	ADARB1 interactions	EEF1B2 EEF1D RBM25 ZBTB33 CEBPZ BMS1 ZNF638 CHD4 MPHOSPH10 SSRP1 TOP2A TOP2B DDX10	2.95e-07	489	91	13	int:ADARB1
Interaction	RBM4B interactions	CEBPZ XRN1 ZNF638 KRI1 LTV1 MPHOSPH10 HNRNPUL1 TOP2A SNX2 DDX10	2.96e-07	262	91	10	int:RBM4B
Interaction	NAA40 interactions	EEF1B2 ZBTB33 WASHC2C CWC15 ECD CFDP1 RSF1 XRN1 ZNF638 LTV1 CHD4 HNRNPUL1 SSRP1 NCAPH ERBIN TOP2A TOP2B DDX10	3.14e-07	978	91	18	int:NAA40
Interaction	BIRC3 interactions	EEF1B2 EEF1D RBM25 CEBPZ CCDC47 SUPT6H CTR9 BMS1 RCN2 KRI1 NOL7 APLP2 CHD4 HNRNPUL1 SSRP1 IPO4 SEC63 TOP2A SNX2 TOP2B DDX10	3.72e-07	1334	91	21	int:BIRC3
Interaction	POLR1E interactions	VPS72 CEBPZ CTR9 BMS1 KRI1 MPHOSPH10 TAF1 HNRNPUL1 SSRP1 TOP2B PPM1G	5.08e-07	350	91	11	int:POLR1E
Interaction	RPS24 interactions	EEF1B2 CEBPZ BMS1 KRI1 LTV1 CHD4 MPHOSPH10 CTNNA1 NCAPH TOP2A TOP2B PPM1G DDX10	7.17e-07	529	91	13	int:RPS24
Interaction	H2BC9 interactions	FRAS1 VPS72 OTOF CEBPZ CFDP1 CUL9 NOL7 AKAP11 CHD4 SSRP1 CFAP44 TOP2A	7.74e-07	446	91	12	int:H2BC9
Interaction	H2AZ1 interactions	VPS72 CFDP1 RSF1 AKAP11 CHD4 SSRP1 NCAPH TOP2A TOP2B MYLK2 PPM1G	9.01e-07	371	91	11	int:H2AZ1
Interaction	RAD18 interactions	SLC4A1AP SUPT6H CTR9 RSF1 ZNF638 CHD4 CTNNA1 HNRNPUL1 SSRP1 ERBIN TOP2A TOP2B	9.99e-07	457	91	12	int:RAD18
Interaction	COIL interactions	CEBPZ MYO10 SUPT6H CTR9 UVSSA CFDP1 BMS1 CHD4 TAF1 SSRP1 IPO4 TOP2A TOP2B	1.15e-06	552	91	13	int:COIL
Interaction	H2AC8 interactions	CFDP1 RSF1 KRI1 LTV1 MPHOSPH10 SSRP1 MYLK2 PPM1G	1.38e-06	177	91	8	int:H2AC8
Interaction	NOP56 interactions	CEBPZ BMS1 SMARCA2 RCN2 KRI1 CHD4 MPHOSPH10 SSRP1 TOP2A TOP2B MYLK2 PPM1G DDX10	1.65e-06	570	91	13	int:NOP56
Interaction	HECTD1 interactions	RBM25 CEBPZ BMS1 XRN1 KRI1 NOL7 LTV1 CHD4 MPHOSPH10 TAF1 HNRNPUL1 SSRP1 NCAPH ZNHIT3 TOP2A TOP2B DDX10	1.68e-06	984	91	17	int:HECTD1
Interaction	DHX40 interactions	CEBPZ SUPT6H CTR9 BMS1 ZNF638 KRI1 MPHOSPH10 TAF1 DDX10	1.89e-06	249	91	9	int:DHX40
Interaction	H3C1 interactions	CTR9 CFDP1 RSF1 SMARCA2 ZNF638 KRI1 LTV1 CHD4 TAF1 SSRP1 IPO4 TOP2A TOP2B MYLK2 PPM1G DDX10	2.49e-06	901	91	16	int:H3C1
Interaction	H2BC21 interactions	VPS72 OTOF SUPT6H CTR9 CFDP1 RSF1 ZNF638 AKAP11 CHD4 SSRP1 TOP2A TOP2B PPM1G BAHCC1	2.75e-06	696	91	14	int:H2BC21
Interaction	SUPT16H interactions	RBM25 CCDC82 SUPT6H CTR9 RSF1 SMARCA2 KRI1 CHD4 SSRP1 TOP2B PPM1G	4.88e-06	442	91	11	int:SUPT16H
Interaction	CEBPB interactions	EEF1B2 EEF1D RBM25 ZBTB33 CCDC47 CTR9 RSF1 BMS1 XRN1 SMARCA2 RCN2 ZNF638 NOL7 CHD4 MPHOSPH10 HNRNPUL1 SSRP1 NCAPH TOP2A PPM1G	5.28e-06	1443	91	20	int:CEBPB
Interaction	DNAJC1 interactions	RAB3GAP1 CCDC47 ECD VPS13A RCN2 AKAP11 LTV1 SEC63 PBXIP1 PPM1G	5.33e-06	361	91	10	int:DNAJC1
Interaction	EFTUD2 interactions	EEF1B2 EEF1D CEBPZ CCDC47 CTR9 ECD PBK SMARCA2 ZNF638 KRI1 CUL9 LTV1 CHD4 CTNNA1 HNRNPUL1 SSRP1 NCAPH TOP2A TOP2B PPM1G	5.62e-06	1449	91	20	int:EFTUD2
Interaction	FBL interactions	CEBPZ ZNF316 BMS1 KRI1 NOL7 LTV1 CHD4 MPHOSPH10 SSRP1 ZNHIT3 TOP2A TOP2B DDX10	5.74e-06	639	91	13	int:FBL
Interaction	ZBTB2 interactions	CEBPZ RSF1 BMS1 PBK KRI1 LTV1 CHD4 SSRP1 TOP2A TOP2B DDX10	5.78e-06	450	91	11	int:ZBTB2
Interaction	TERF2IP interactions	VPS72 SLC4A1AP SUPT6H CWC15 CFDP1 RSF1 ZNF638 TAF1 SSRP1 TOP2A PPM1G DDX10	6.98e-06	552	91	12	int:TERF2IP
Interaction	RNF2 interactions	EEF1D ZBTB33 CEBPZ RSF1 BMS1 ZNF638 NOL7 CHD4 MPHOSPH10 HNRNPUL1 SSRP1 IPO4 NCAPH PBXIP1 TOP2A	7.22e-06	866	91	15	int:RNF2
Interaction	VAPB interactions	PITPNM2 OSBP RAB3GAP1 CEBPZ CCDC47 VPS13A PITPNM3 AKAP11 SEC63 WASHC2A SNX2	7.72e-06	464	91	11	int:VAPB
Interaction	RPL35 interactions	EEF1B2 CEBPZ BMS1 KRI1 LTV1 CHD4 MPHOSPH10 HNRNPUL1 NCAPH TOP2A TOP2B DDX10	7.78e-06	558	91	12	int:RPL35
Interaction	DNAJB6 interactions	MYO10 SUPT6H CTR9 BMS1 PBK KRI1 SSRP1 SNX2 PPM1G DDX10	8.16e-06	379	91	10	int:DNAJB6
Interaction	H3C6 interactions	RBM25 SUPT6H CWC15 BMS1 CHD4 SSRP1 IPO4 TOP2A	8.44e-06	226	91	8	int:H3C6
Interaction	DNAJC8 interactions	SLC4A1AP CTR9 BMS1 LTV1 SSRP1 TOP2B PPM1G DDX10	9.59e-06	230	91	8	int:DNAJC8
Interaction	H2AC17 interactions	CFDP1 BMS1 XRN1 KRI1 LTV1 SSRP1 PPM1G DDX10	1.02e-05	232	91	8	int:H2AC17
Interaction	USP36 interactions	CEBPZ BMS1 ZNF638 KRI1 NOL7 CHD4 MPHOSPH10 SSRP1 TOP2A PRIMPOL PPM1G DDX10	1.58e-05	599	91	12	int:USP36
Interaction	TCEANC2 interactions	SLC4A1AP CTR9 WASHC2A PPM1G	1.63e-05	34	91	4	int:TCEANC2
Interaction	EGLN3 interactions	DMXL2 HROB RAB3GAP1 ZBTB33 CCDC47 ECD CCSER2 XRN1 RCN2 AKAP11 LTV1 CTNNA1 IPO4 NCAPH ERBIN SNX2 PPM1G CDC42EP1	1.66e-05	1296	91	18	int:EGLN3
Interaction	CHD4 interactions	RBM25 SUPT6H CTR9 RSF1 BMS1 XRN1 SMARCA2 ZNF638 KRI1 CHD4 SSRP1 NCAPH TOP2A TOP2B DDX10	1.86e-05	938	91	15	int:CHD4
Interaction	H2BC26 interactions	VPS72 CEBPZ CFDP1 BMS1 KRI1 SSRP1 PPM1G	1.93e-05	183	91	7	int:H2BC26
Interaction	WWTR1 interactions	RBM25 ZBTB33 VPS72 CEBPZ XRN1 SSRP1 NCAPH ERBIN TOP2A SNX2	2.07e-05	422	91	10	int:WWTR1
Interaction	FGFBP1 interactions	CEBPZ BMS1 ZNF638 KRI1 LTV1 MPHOSPH10 SSRP1 DDX10	2.14e-05	257	91	8	int:FGFBP1
Interaction	RPS16 interactions	RBM25 CCDC47 BMS1 XRN1 KRI1 LTV1 CHD4 MPHOSPH10 HNRNPUL1 NCAPH TOP2A TOP2B DDX10	2.16e-05	724	91	13	int:RPS16
Interaction	NUP43 interactions	VPS72 CEBPZ SUPT6H RSF1 ZNF316 BMS1 CCSER2 KRI1 MPHOSPH10 SSRP1 TOP2A TOP2B	2.40e-05	625	91	12	int:NUP43
Interaction	SIRT6 interactions	VPS72 CEBPZ SUPT6H CTR9 CCSER2 SMARCA2 CHD4 MPHOSPH10 HNRNPUL1 SSRP1 TOP2A TOP2B	2.52e-05	628	91	12	int:SIRT6
Interaction	SRRM1 interactions	RBM25 CWC15 ZNF638 LTV1 CHD4 SSRP1 TOP2A TOP2B ARHGEF10L	2.78e-05	348	91	9	int:SRRM1
Interaction	H3-3A interactions	SLC4A1AP CFDP1 RSF1 CHD4 TAF1 SSRP1 IPO4 TOP2A SNX2 TOP2B MYLK2 PPM1G DDX10	3.08e-05	749	91	13	int:H3-3A
Interaction	UHRF2 interactions	ZBTB33 PEG3 RSF1 ZNF638 SSRP1 TOP2A TOP2B	3.42e-05	200	91	7	int:UHRF2
Interaction	ZC3H10 interactions	CEBPZ BMS1 XRN1 ZNF638 KRI1 MPHOSPH10 DDX10	3.42e-05	200	91	7	int:ZC3H10
Interaction	H2AB3 interactions	CEBPZ BMS1 ZNF638 KRI1 SSRP1 PPM1G	3.52e-05	136	91	6	int:H2AB3
Interaction	PRPF19 interactions	STRN RBM25 CWC15 ECD CHD4 CTNNA1 SSRP1 NCAPH ZNHIT3 TOP2A	3.57e-05	450	91	10	int:PRPF19
Interaction	RPL11 interactions	EEF1B2 EEF1D COPS9 CEBPZ BMS1 LTV1 CHD4 MPHOSPH10 SSRP1 NCAPH TOP2A DDX10	3.63e-05	652	91	12	int:RPL11
Interaction	HOOK3 interactions	STRN WASHC2C RCN2 KRI1 LTV1 WASHC2A SNX2	3.64e-05	202	91	7	int:HOOK3
Interaction	RPA4 interactions	EEF1B2 STRN RBM25 RIPOR2 ZNF638 SSRP1 SEC63 WASHC2A NCAPH TOP2A	3.70e-05	452	91	10	int:RPA4
Interaction	BAZ1B interactions	EEF1B2 SUPT6H RSF1 SMARCA2 CHD4 TOP2A TOP2B	3.88e-05	204	91	7	int:BAZ1B
Interaction	SNRNP200 interactions	EEF1D CWC15 ECD CUL9 LTV1 CHD4 SSRP1 IPO4 WASF1 TOP2B	4.29e-05	460	91	10	int:SNRNP200
Interaction	DNAJC25 interactions	FRAS1 RAB3GAP1 CCDC47 VPS13A RCN2 SEC63 PBXIP1 PPM1G	4.36e-05	284	91	8	int:DNAJC25
Interaction	H1-2 interactions	SLC4A1AP CEBPZ CTR9 RSF1 BMS1 XRN1 KRI1 APLP2 AKAP11 CHD4 MPHOSPH10 NCAPH	4.46e-05	666	91	12	int:H1-2
Interaction	MEN1 interactions	EEF1D RBM25 WASHC2C CEBPZ BMS1 ZNF638 KRI1 CHD4 MPHOSPH10 TAF1 SSRP1 ERBIN TOP2A TOP2B DDX10	5.40e-05	1029	91	15	int:MEN1
Interaction	DNAJC9 interactions	CEBPZ CTR9 BMS1 HNRNPUL1 SSRP1 IPO4 PPM1G DDX10	5.83e-05	296	91	8	int:DNAJC9
Interaction	SNRPA interactions	EEF1B2 RBM25 SUPT6H CTR9 CWC15 ZNF638 HNRNPUL1 SSRP1 TOP2A PPM1G	6.35e-05	482	91	10	int:SNRPA
Interaction	CDK8 interactions	SLC4A1AP CTR9 SMARCA2 TAF1 PBXIP1 PPM1G DDX10	6.62e-05	222	91	7	int:CDK8
Interaction	TOP1 interactions	RBM25 SUPT6H CTR9 CWC15 CFDP1 RSF1 ZNF638 CHD4 SSRP1 TOP2A TOP2B MYLK2	6.81e-05	696	91	12	int:TOP1
Interaction	ERCC6 interactions	SUPT6H CTR9 UVSSA SMARCA2 CHD4 TOP2A TOP2B	7.00e-05	224	91	7	int:ERCC6
Interaction	NLE1 interactions	CEBPZ RSF1 KRI1 MPHOSPH10 SSRP1 TOP2A TOP2B	7.82e-05	228	91	7	int:NLE1
Interaction	NPM1 interactions	EEF1B2 OSBP EEF1D CEBPZ BMS1 ZNF638 KRI1 AKAP11 CHD4 MPHOSPH10 SSRP1 NCAPH TOP2A TOP2B PPM1G DDX10	8.62e-05	1201	91	16	int:NPM1
Interaction	PHF14 interactions	CFDP1 APLP2 CHD4 SSRP1 PPM1G	9.02e-05	100	91	5	int:PHF14
Interaction	SRSF6 interactions	CEBPZ BMS1 XRN1 ZNF638 KRI1 LTV1 CHD4 MPHOSPH10 SSRP1 DDX10	9.03e-05	503	91	10	int:SRSF6
Interaction	HSF1 interactions	EEF1D RBM25 SUPT6H CWC15 RCN2 CHD4 TAF1 HNRNPUL1 SSRP1 NCAPH TOP2A	9.29e-05	609	91	11	int:HSF1
Interaction	KAT6A interactions	CEBPZ CCDC47 CTR9 RSF1 NOL7 LTV1 CHD4 MPHOSPH10 SSRP1 TOP2A	1.01e-04	510	91	10	int:KAT6A
Interaction	CUL7 interactions	EEF1B2 EEF1D RBM25 SUPT6H ZNF638 CUL9 NOL7 CHD4 CTNNA1 HNRNPUL1 SSRP1 TOP2A TOP2B	1.05e-04	845	91	13	int:CUL7
Interaction	SNRNP70 interactions	RAB3GAP1 RBM25 CWC15 BMS1 ZNF638 KRI1 LTV1 CHD4 MPHOSPH10 HNRNPUL1 SSRP1 TOP2A SNX2 TOP2B	1.27e-04	984	91	14	int:SNRNP70
Interaction	KLF16 interactions	ZBTB33 VPS72 CTR9 RCN2 KRI1 LTV1 TAF1 HNRNPUL1 DDX10	1.29e-04	425	91	9	int:KLF16
Interaction	FGF8 interactions	CEBPZ BMS1 XRN1 MPHOSPH10 DDX10	1.30e-04	108	91	5	int:FGF8
Interaction	KCNA3 interactions	RBM25 ZBTB33 CCDC47 VPS13A XRN1 DOCK10 RCN2 LTV1 CTNNA1 SEC63 ERBIN PPM1G CDC42EP1	1.42e-04	871	91	13	int:KCNA3
Interaction	RPS6 interactions	CEBPZ CFDP1 RSF1 BMS1 XRN1 KRI1 LTV1 CHD4 MPHOSPH10 NCAPH TOP2A TOP2B DDX10	1.47e-04	874	91	13	int:RPS6
Interaction	CHD3 interactions	RBM25 CEBPZ SUPT6H CTR9 SMARCA2 KRI1 CHD4 TAF1 SSRP1 TOP2A TOP2B DDX10	1.50e-04	757	91	12	int:CHD3
Interaction	CBX3 interactions	VPS72 SLC4A1AP CFDP1 RSF1 ZNF316 RCN2 CHD4 SSRP1 TOP2A TOP2B PPM1G	1.56e-04	646	91	11	int:CBX3
Interaction	H2BC1 interactions	VPS72 CFDP1 SMARCA2 CHD4 SSRP1 PPM1G	1.56e-04	178	91	6	int:H2BC1
Interaction	RPL8 interactions	EEF1B2 CEBPZ MYO10 BMS1 XRN1 CHD4 MPHOSPH10 NCAPH TOP2A DDX10	1.59e-04	539	91	10	int:RPL8
Interaction	PTGES3 interactions	OSBP MYLK PHOSPHO1 CTR9 ECD TOP2A TOP2B ARHGEF10L DDX10	1.59e-04	437	91	9	int:PTGES3
Interaction	RPL4 interactions	EEF1B2 CEBPZ BMS1 XRN1 ZNF638 KRI1 CHD4 MPHOSPH10 SEC63 NCAPH TOP2A DDX10	1.64e-04	764	91	12	int:RPL4
Interaction	H2BC10 interactions	VPS72 CFDP1 SSRP1 PPM1G	1.67e-04	61	91	4	int:H2BC10
Interaction	NAP1L1 interactions	OSBP WASHC2C CFDP1 LTV1 CTNNA1 SSRP1 MYLK2 PPM1G	1.68e-04	345	91	8	int:NAP1L1
Interaction	H2BC6 interactions	VPS72 CFDP1 SSRP1 PPM1G	1.78e-04	62	91	4	int:H2BC6
GeneFamily	Topoisomerases	TOP2A TOP2B	1.35e-04	6	55	2	1050
GeneFamily	WASH complex	WASHC2C WASHC2A	1.35e-04	6	55	2	1331
GeneFamily	Phosphatidylinositol transfer proteins	PITPNM2 PITPNM3	1.35e-04	6	55	2	1151
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	AKAP11 WASF1	3.50e-03	29	55	2	396
GeneFamily	Sorting nexins\|PX-BAR domain containing	SNX21 SNX2	3.50e-03	29	55	2	754
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OSBP MYO10 DOCK9 DOCK10	3.55e-03	206	55	4	682
Coexpression	HAMAI_APOPTOSIS_VIA_TRAIL_UP	SLC4A1AP CEBPZ MYO10 CCDC47 RSF1 PBK SMARCA2 DOCK10 RCN2 ZNF638 AKAP11 MPHOSPH10 SEC63 SNX2 TOP2B DDX10	1.07e-09	656	92	16	M18979
Coexpression	MENON_FETAL_KIDNEY_0_CAP_MESENCHYME_CELLS	RBM25 RSF1 CHD4 TOP2A TOP2B PPM1G	7.79e-07	90	92	6	M39250
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	DMXL2 RAB3GAP1 MYO10 DOCK9 CCSER2 VPS13A SMARCA2 ZNF638 AKAP11 SPIDR WASF1 TOP2A SNX2 DDX10	1.68e-06	856	92	14	M4500
Coexpression	PUJANA_ATM_PCC_NETWORK	EEF1B2 STRN RIPOR2 ZBTB33 CEBPZ CTR9 ECD BMS1 DOCK10 RCN2 CUL9 TAF1 ZNHIT3 TOP2A SNX2 TOP2B DDX10	6.28e-06	1394	92	17	M9585
Coexpression	GSE22432_MULTIPOTENT_VS_COMMON_DC_PROGENITOR_UP	CEBPZ CCDC47 LTV1 MPHOSPH10 TYSND1 WASHC2A PPM1G	6.64e-06	199	92	7	M7821
Coexpression	GSE22432_CDC_VS_COMMON_DC_PROGENITOR_DN	CFDP1 PBK APLP2 LTV1 WASHC2A TOP2B FRMD3	6.64e-06	199	92	7	M7824
Coexpression	HOUNKPE_HOUSEKEEPING_GENES	OSBP EEF1D RAB3GAP1 RBM25 SLC4A1AP CEBPZ CCDC47 SUPT6H CFDP1 NOL7 LTV1 MPHOSPH10 HNRNPUL1 SSRP1 YIPF3	8.67e-06	1129	92	15	M42508
Coexpression	SCIBETTA_KDM5B_TARGETS_DN	STRN PBK SMARCA2 NCAPH TOP2A	8.76e-06	79	92	5	M6787
Coexpression	HOUNKPE_HOUSEKEEPING_GENES	OSBP EEF1D RAB3GAP1 RBM25 SLC4A1AP CEBPZ CCDC47 SUPT6H CFDP1 NOL7 LTV1 MPHOSPH10 HNRNPUL1 SSRP1 YIPF3	1.17e-05	1158	92	15	MM1338
Coexpression	GCNP_SHH_UP_LATE.V1_UP	CFDP1 ZNF638 MPHOSPH10 FANCM TOP2A TOP2B	4.35e-05	181	92	6	M2641
Coexpression	ENK_UV_RESPONSE_KERATINOCYTE_DN	MYO10 SMARCA2 ZNF638 NOL7 AKAP11 CTNNA1 WASF1 TOP2A TOP2B	4.94e-05	481	92	9	M3898
Coexpression	CAIRO_HEPATOBLASTOMA_CLASSES_UP	EEF1B2 EEF1D CCDC47 PBK NOL7 SSRP1 IPO4 ZNHIT3 TOP2A DDX10	5.79e-05	612	92	10	M4772
Coexpression	GSE37534_UNTREATED_VS_ROSIGLITAZONE_TREATED_CD4_TCELL_PPARG1_AND_FOXP3_TRASDUCED_UP	DOCK9 VPS13A PITPNM3 ATP9B CHD4 BAHCC1	6.96e-05	197	92	6	M8983
Coexpression	FRASOR_RESPONSE_TO_SERM_OR_FULVESTRANT_UP	STRN RCN2 CD302	7.04e-05	23	92	3	M8108
Coexpression	GSE15139_GMCSF_TREATED_VS_UNTREATED_NEUTROPHILS_DN	CCDC82 UVSSA RCN2 CTNNA1 SEC63 PPM1G	7.36e-05	199	92	6	M7099
Coexpression	GSE22886_NAIVE_TCELL_VS_DC_UP	EEF1B2 EEF1D RIPOR2 DOCK9 RCN2 PBXIP1	7.36e-05	199	92	6	M4475
Coexpression	GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN	RIPOR2 CWC15 ZNF638 TYSND1 SNX2 DDX10	7.57e-05	200	92	6	M3628
Coexpression	GSE37301_MULTIPOTENT_PROGENITOR_VS_RAG2_KO_NK_CELL_DN	VPS72 CEBPZ CFDP1 NOL7 LTV1 SSRP1	7.57e-05	200	92	6	M8851
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HPROGM	PBK CFAP44 NCAPH PBXIP1 HYDIN TOP2A FRMD3	1.06e-04	307	92	7	M39058
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEBPZ RSF1 XRN1 DOCK10 ZNF638 CHD4 HNRNPUL1 ERBIN TOP2B	1.71e-10	184	92	9	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSF1 XRN1 DOCK10 ZNF638 CHD4 HNRNPUL1 ERBIN TOP2B	4.87e-09	185	92	8	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	EEF1D COPS9 RBM25 CFDP1 RSF1 ZNF638 KRI1 TOP2A	7.96e-09	197	92	8	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_1\|Classical_Monocyte / Disease condition and Cell class	COPS9 RIPOR2 WASHC2C OTOF WASHC2A ERBIN	1.72e-06	175	92	6	35ea2ed93538e6bf803029fcf7d9243f93e7733d
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PEG3 XRN1 ZNF638 HNRNPUL1 ERBIN TOP2B	1.78e-06	176	92	6	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_1\|COVID-19_Severe / Disease condition and Cell class	COPS9 RIPOR2 WASHC2C OTOF WASHC2A ERBIN	2.09e-06	181	92	6	0d07a67e8ee3bca687b378afbc4044434e63556d
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XRN1 DOCK10 ZNF638 HNRNPUL1 ERBIN TOP2B	2.16e-06	182	92	6	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APLP2 AKAP11 HNRNPUL1 MGAT4C ERBIN TOP2B	2.85e-06	191	92	6	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APLP2 AKAP11 HNRNPUL1 MGAT4C ERBIN TOP2B	2.85e-06	191	92	6	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APLP2 AKAP11 HNRNPUL1 MGAT4C ERBIN TOP2B	2.85e-06	191	92	6	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DMXL2 RIPOR2 WASHC2C APLP2 WASHC2A ERBIN	2.94e-06	192	92	6	b86476037ddf8904c1d8a6b3763af7242c031cf3
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	EEF1D RBM25 VPS13A KRI1 APLP2 TOP2A	2.94e-06	192	92	6	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMXL2 RIPOR2 WASHC2C OTOF APLP2 ERBIN	3.03e-06	193	92	6	4fb020f11fd7aff06952bfeaabc79b2c7b8873f6
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DMXL2 RIPOR2 WASHC2C OTOF APLP2 ERBIN	3.12e-06	194	92	6	885355ebe98e974f841cc59dce3b5228c642c5d0
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_3\|Classical_Monocyte / Disease condition and Cell class	COPS9 RIPOR2 WASHC2C APLP2 WASHC2A ERBIN	3.31e-06	196	92	6	15397ec27167bb2fb6fec120b68bf38fc71b2670
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_3\|COVID-19_Mild / Disease condition and Cell class	COPS9 RIPOR2 WASHC2C APLP2 WASHC2A ERBIN	3.31e-06	196	92	6	f245e929a286cb097130572e1027b4f01be8b04d
ToppCell	myeloid-pro-pDC\|myeloid / Lineage and Cell class	MYLK PBK NCAPH WASF1 TOP2A BAHCC1	3.31e-06	196	92	6	70daf4fabb68aecc5cc9f03d6f6495dd29b74a16
ToppCell	Control-Classical_Monocyte-cMono_2\|Classical_Monocyte / Disease condition and Cell class	DMXL2 COPS9 RIPOR2 APLP2 ERBIN SNX2	3.40e-06	197	92	6	eb7610c9496a95a5fd866e16abcbc39b83abe617
ToppCell	10x3'2.3-week_12-13-Lymphocytic_B-B_lineage-pre_pro_B_progenitor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PBK SSRP1 NCAPH TOP2A SNX2 TOP2B	3.61e-06	199	92	6	8e7f9312dec1e3a92b6a0ccc7baa2d46e89c11f3
ToppCell	MS-IIF-Lymphocyte-T/NK-dn_T\|IIF / Disease, condition lineage and cell class	CCSER2 PITPNM3 NCAPH PBXIP1 TOP2A PPM1G	3.71e-06	200	92	6	c34fff02992cba6bcc2308019cb00b94e1227300
ToppCell	IIF-Lymphocyte-T_NK-dnT\|IIF / Disease, Lineage and Cell Type	CCSER2 PITPNM3 NCAPH TOP2A PPM1G	1.32e-05	146	92	5	d0f361662db5f7be26104346e8431f7e30c5ce3a
ToppCell	Severe-B_naive-1\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RIPOR2 WASHC2C APLP2 WASHC2A ERBIN	1.99e-05	159	92	5	2881b054bbeb479221ee3c38bbd9b0815b123579
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK9 CCSER2 VPS13A DOCK10 PBXIP1	2.51e-05	167	92	5	83969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VPS13A XRN1 CHD4 ERBIN TOP2B	3.79e-05	182	92	5	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VPS13A XRN1 CHD4 ERBIN TOP2B	3.79e-05	182	92	5	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	COVID-19_Mild-NK_activated\|COVID-19_Mild / Disease condition and Cell class	COPS9 RIPOR2 WASHC2C WASHC2A ERBIN	3.89e-05	183	92	5	22bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCell	367C-Lymphocytic-NK_cells-Proliferating_NK_cell\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	HROB PBK CUL9 NCAPH TOP2A	3.89e-05	183	92	5	a716b446c2bf5aa294b8f580aa845098fae76354
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c11-MKI67-FOS\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PBK SSRP1 NCAPH TOP2A PPM1G	3.99e-05	184	92	5	7f8488dbb1ee41372cdbcd34a2e14b377218bf0f
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	RAB3GAP1 MYLK CCSER2 TAF1 ERBIN	4.21e-05	186	92	5	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HROB DOCK9 PBK NCAPH TOP2A	4.65e-05	190	92	5	31de1727822e9818652946dfb962daee77ffad68
ToppCell	facs-GAT-Fat-3m\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COPS9 PEG3 APLP2 CTNNA1 ERBIN	4.65e-05	190	92	5	1d92be1b41cff59e834a9d28868f554bd1f3e471
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMXL2 RIPOR2 WASHC2C APLP2 ERBIN	4.77e-05	191	92	5	c9f3bdb5c0a90268cab24a0fe4c3a8290fcedeb8
ToppCell	(1)_Control_(PBS)\|World / Stress and Cell class	MYLK MYO10 APLP2 CD302 SNX21	4.77e-05	191	92	5	b346e13259cb2d506b923ad44b894c21a3eee4c3
ToppCell	COVID-19-T_cells-CD4+_T_cells\|COVID-19 / group, cell type (main and fine annotations)	RIPOR2 DOCK9 CCSER2 DOCK10 PBXIP1	4.77e-05	191	92	5	0646cca78e24aeb6baa9934d3c439b797c567997
ToppCell	facs-BAT-Fat-3m-Endothelial-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO10 DOCK9 APLP2 CTNNA1 CDC42EP1	5.01e-05	193	92	5	e340064cd146deac03f2d0fd43e2e218bb6057c9
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	STRN ZBTB33 CTR9 RSF1 CD302	5.01e-05	193	92	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	facs-BAT-Fat-3m-Endothelial-endothelial_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO10 DOCK9 APLP2 CTNNA1 CDC42EP1	5.01e-05	193	92	5	a211b386fd0fb9da9937361d29d90925a72c9715
ToppCell	facs-BAT-Fat-3m-Endothelial\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO10 DOCK9 APLP2 CTNNA1 CDC42EP1	5.01e-05	193	92	5	3086c33f4d6fab66966818737f95ae4d6b2615b0
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYO10 SMARCA2 APLP2 CTNNA1 CDC42EP1	5.14e-05	194	92	5	6115c20ffe414378508f3879e67815b6062341a7
ToppCell	PND28-Endothelial-Endothelial_blood-vessel\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYO10 SMARCA2 APLP2 CTNNA1 CDC42EP1	5.14e-05	194	92	5	6317e9cdf96eb020f84d50bf41f803db5c9c04a0
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HNRNPUL1 SEC63 TOP2A SNX2 TOP2B	5.14e-05	194	92	5	8ef0b71fef5b84cfd04973f891215333e7035d1d
ToppCell	PND28-Endothelial\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYO10 SMARCA2 APLP2 CTNNA1 CDC42EP1	5.14e-05	194	92	5	b592c713204db7ae2f34a54f2d03d13834593c57
ToppCell	Control-Classical_Monocyte-cMono_2\|Control / Disease condition and Cell class	DMXL2 COPS9 RIPOR2 APLP2 ERBIN	5.26e-05	195	92	5	0fea64ee3eedf3929abb0dd9c5f5fc72f181eed9
ToppCell	BLOOD--(1)_Activated_T_cells\| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PBK NCAPH PBXIP1 TOP2A PPM1G	5.26e-05	195	92	5	45515d5da8a8c8242eb70a1bea24fe44eca5407b
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO10 PEG3 VPS13A XRN1 CHD4	5.26e-05	195	92	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_4\|COVID-19_Mild / Disease condition and Cell class	DMXL2 RBM25 RIPOR2 OTOF ERBIN	5.39e-05	196	92	5	3729d1444c65cad640377894decc64129bc3fd5b
ToppCell	B_cell_maturation-CD34+_pro-B\|World / Lineage and Cell class	MYLK SSRP1 TOP2A TOP2B BAHCC1	5.39e-05	196	92	5	4cb046883e56524963f6469ddb3b82c3c9853379
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FRAS1 RBM25 VPS13A XRN1 SMARCA2	5.52e-05	197	92	5	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	10x5'-GI_large-bowel-Lymphocytic_B-GC_B_(I)\|GI_large-bowel / Manually curated celltypes from each tissue	HROB PBK SSRP1 NCAPH TOP2A	5.52e-05	197	92	5	80a0cfbd454409594effead7082586b06c2f411a
ToppCell	normal_Lung-Fibroblasts-COL13A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	FRAS1 MYLK MYO10 APLP2 CD302	5.66e-05	198	92	5	e0e47cf65774191981840b22905b2094b95abe0f
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Stem_cells-Stem_cells\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	MYLK PBK NCAPH TOP2A MYLK2	5.66e-05	198	92	5	50f236ab7ef6f00721f6cd714e3eee183077beeb
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	RBM25 CCDC47 RSF1 SMARCA2 NOL7	5.66e-05	198	92	5	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Stem_cells\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	MYLK PBK NCAPH TOP2A MYLK2	5.66e-05	198	92	5	dc0c6189ff9dd76675f63acf1cbc7dda60e75f3f
ToppCell	(02)_MMP9/10+-(2)_GFP_FOXI1\|(02)_MMP9/10+ / shred by cell type by condition	MYLK RSF1 CCSER2 SMARCA2 SEC63	5.79e-05	199	92	5	18a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell	Non-neuronal-Dividing\|World / Primary Cells by Cluster	EEF1D MYO10 PBK NCAPH TOP2A	5.93e-05	200	92	5	50fa7b34a05f2c5ebbc7d113bd8e31326688a231
ToppCell	facs-Brain_Non-Myeloid-Hippocampus\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC47 DOCK10 APLP2 ERBIN CDC42EP1	5.93e-05	200	92	5	fc28f71ca1cd0fdae66009ae5afe175d22f2bd8c
ToppCell	Control-Control-Myeloid-immature_Neutrophil\|Control / Disease, condition lineage and cell class	DMXL2 ZBTB33 VPS13A NCAPH TOP2A	5.93e-05	200	92	5	118321ac443feb42aee171baccfc4610f00a8822
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PITPNM2 MYLK DOCK9 CTNNA1 CDC42EP1	5.93e-05	200	92	5	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	Non-neuronal-Dividing-IPC\|World / Primary Cells by Cluster	EEF1D MYO10 PBK NCAPH TOP2A	5.93e-05	200	92	5	971533181daa1bfac1f1b8c507d2013f891f9078
ToppCell	MS-IIF-Lymphocyte-T/NK-T/NK_proliferative\|IIF / Disease, condition lineage and cell class	HROB PBK SSRP1 NCAPH TOP2A	5.93e-05	200	92	5	c7c1806a1054b2b034a26a18aac93fc3bec4dbc8
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors_nGenesUnder4k\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	EEF1D PBK SSRP1 NCAPH TOP2A	5.93e-05	200	92	5	243c7f88befd402a57e9226706811c802b28e3fd
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-matrix_-_immature_4\|E18.5-samps / Age Group, Lineage, Cell class and subclass	RGS22 PBK NCAPH TOP2A	1.53e-04	130	92	4	169d88bffd7cd813a484d809defa638ceaca4bcb
ToppCell	LPS_only-Endothelial-Endothelial-FOXM1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RGS22 PBK NCAPH TOP2A	1.72e-04	134	92	4	4d8f7ddad02fe76a614771e115ebb8e04623ba85
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPPLY2 EGFLAM WASF1 HYDIN	1.97e-04	139	92	4	27dd36f5ef03fa97f0fdb19fbd259cb60e7962b3
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPPLY2 EGFLAM WASF1 HYDIN	1.97e-04	139	92	4	2a54627947f8c6597c041f4785f8a4e52d0edfba
ToppCell	Severe-B_naive-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RIPOR2 WASHC2C WASHC2A ERBIN	2.03e-04	140	92	4	683ee5e103f0c68cbbec019249404d381dbc39f3
ToppCell	Mild/Remission-B_naive-1\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RIPOR2 WASHC2C WASHC2A ERBIN	2.20e-04	143	92	4	bd3f5fbd4e9e4dc414682db5607494f3ce988deb
ToppCell	Control-B_intermediate-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RIPOR2 WASHC2C WASHC2A ERBIN	2.26e-04	144	92	4	984470ff6ddce4c743e2db78fa98dae055aaa273
ToppCell	Dividing_Macrophages-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	HROB PBK NCAPH TOP2A	2.51e-04	148	92	4	66b51aa6690bf8fbc90fa5a6f86191703e2d5046
ToppCell	368C-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	HROB ZNF316 PBK TOP2A	2.64e-04	150	92	4	c3ad5fa41eb636a5d691c0268c0f1c32cd0de658
ToppCell	368C-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	HROB ZNF316 PBK TOP2A	2.64e-04	150	92	4	78b8029e71d26f336a46274c8afef3435bf536b9
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_D2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	EEF1B2 PHOSPHO1 CD302 SNX21	2.92e-04	154	92	4	8dc8f02534c3ebda30bf9e702e36d0c53d89e5a5
ToppCell	Control-B_naive-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RIPOR2 WASHC2C WASHC2A ERBIN	2.99e-04	155	92	4	0a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCell	390C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|390C / Donor, Lineage, Cell class and subclass (all cells)	HROB PBK NCAPH TOP2A	3.29e-04	159	92	4	0fbfdb18b7ed4bde077add13f2b3636e144b254f
ToppCell	RV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	MYLK DOCK10 EGFLAM FRMD3	3.37e-04	160	92	4	29c9b4770d0e73d59cffc7937b179484c76b6dcc
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-Pre-B\|bone_marrow / Manually curated celltypes from each tissue	PITPNM2 PDE4C MYLK WASF1	3.54e-04	162	92	4	e088e66aabc307dde5d2b9aa295c34ef68155b1a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HROB PBK NCAPH TOP2A	3.62e-04	163	92	4	3f434015c0cbefb31eeda133c34f75384c5f7e22
ToppCell	390C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HROB PBK NCAPH TOP2A	3.62e-04	163	92	4	aa5ea367f787c1543afb7eb80a801432e1c44011
ToppCell	367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HROB PBK NCAPH TOP2A	3.70e-04	164	92	4	fb18b863152fb3109e2224c791c84c6371680a4e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HROB PBK NCAPH TOP2A	3.79e-04	165	92	4	eec2d327c94832d1390314c93ef6a2be4648478b
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_1\|COVID-19_Mild / Disease condition and Cell class	RIPOR2 WASHC2C WASHC2A ERBIN	3.79e-04	165	92	4	ef709c5d3231c65d351316e1e31b9c9eba721628
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FRAS1 STRN CUL9 EGFLAM	3.88e-04	166	92	4	bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCell	10x5'-Liver-Hematopoietic_progenitors\|Liver / Manually curated celltypes from each tissue	FANCM NCAPH TOP2A BAHCC1	3.88e-04	166	92	4	ae967570248cf86ca3ddf55e33bcbb3e4e3684bc
ToppCell	10x5'-Liver-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|Liver / Manually curated celltypes from each tissue	FANCM NCAPH TOP2A BAHCC1	3.88e-04	166	92	4	a176e87aa6eec81d1fb79a028f759182d11b567d
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FRAS1 STRN CUL9 EGFLAM	3.88e-04	166	92	4	5e3b998d740b24f790fad37350d704ca0ea10b77
ToppCell	Control-B_intermediate-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RIPOR2 WASHC2C WASHC2A ERBIN	3.97e-04	167	92	4	948504367ecf58144d9dd74d2ec531358fc4b309
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HROB PBK NCAPH TOP2A	3.97e-04	167	92	4	bc132b51dec4e8f1cd2b2cd89f83641976e09292
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|368C / Donor, Lineage, Cell class and subclass (all cells)	MYLK RIPPLY2 PRIMPOL FRMD3	4.06e-04	168	92	4	1bc6a1915d48f547385ed4f44e118bcc8a4a7b6c
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CCSER2 XRN1 DOCK10 PBXIP1	4.06e-04	168	92	4	5e721268f0baa51d3f640f7f4c41db769ebef210
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ZBTB33 RIPPLY2 PRIMPOL FRMD3	4.06e-04	168	92	4	c66a61d3ec711796313a2c6d2dc39aedbfc20afd
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	MYLK RIPPLY2 PRIMPOL FRMD3	4.06e-04	168	92	4	69f534de0f9a293047bea03cb1b78551087a8df5
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_1\|Classical_Monocyte / Disease condition and Cell class	RIPOR2 WASHC2C WASHC2A ERBIN	4.06e-04	168	92	4	d50078614f7af74dc2aa4081c1708a5156ac51cf
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ZBTB33 RIPPLY2 PRIMPOL FRMD3	4.06e-04	168	92	4	83b4f817d95daa15ae60668e789f97d8a3b2e6dd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HROB PBK NCAPH TOP2A	4.15e-04	169	92	4	0bc8ef341ce307b19018d4ac8de0a4d04254209d
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HROB PBK NCAPH TOP2A	4.15e-04	169	92	4	e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PBK SSRP1 NCAPH TOP2A	4.24e-04	170	92	4	21bfe070e63722672176052b386167ea4c3dc4e5
ToppCell	367C-Lymphocytic-NK_cells-Proliferating_NK_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	HROB PBK NCAPH TOP2A	4.34e-04	171	92	4	4ede6e916e593f208f2f8ccf82ef2335e061fc86
ToppCell	Control-B_naive-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RIPOR2 WASHC2C WASHC2A ERBIN	4.34e-04	171	92	4	d18855b24aadea38fd1e4592f945cf15b85e05f1
ToppCell	Control-PLT_5\|Control / Disease Group and Platelet Clusters	EEF1D COPS9 RIPOR2 SSRP1	4.43e-04	172	92	4	950d0a5b7908ee6ef8d30f123c9c7f7180dd4c26
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOF CTNNA1 SNX21 CDC42EP1	4.43e-04	172	92	4	7fb31ccbcd0204c3612986a6bc20d57ed6825e9c
Drug	psi-tectorigenin	MYLK TOP2B MYLK2	1.03e-05	11	92	3	CID005353911
Drug	Iproniazide phosphate [305-33-9]; Down 200; 14.4uM; MCF7; HT_HG-U133A	ZBTB33 DOCK9 VPS13A SMARCA2 CUL9 TAF1 CFAP44	1.49e-05	196	92	7	2288_DN
Drug	Diltiazem hydrochloride [33286-22-5]; Up 200; 8.8uM; PC3; HG-U133A	FAM174B KRI1 APLP2 HNRNPUL1 PBXIP1 ARHGEF10L CDC42EP1	1.54e-05	197	92	7	1948_UP
Drug	AC1LD6BO	MYLK MYLK2	1.62e-05	2	92	2	CID000612818
Drug	Dexrazoxane	TOP2A TOP2B	1.62e-05	2	92	2	DB00380
Drug	5-undecyloxolan-2-one	MYLK MYLK2	1.62e-05	2	92	2	CID000007785
Drug	F14512	TOP2A TOP2B	1.62e-05	2	92	2	ctd:C534191
Drug	Daunorubicin	TOP2A TOP2B	1.62e-05	2	92	2	DB00694
Drug	Vitamin K 3	RAB3GAP1 MYLK MYO10 CTR9 BMS1 FAM174B KRI1 NOL7 APLP2 LTV1 SNX21 SEC63 NCAPH ERBIN TOP2A TOP2B	3.72e-05	1249	92	16	ctd:D024483
Drug	Ps 9	MYLK MYLK2	4.83e-05	3	92	2	CID000066348
Drug	MS-444	MYLK MYLK2	4.83e-05	3	92	2	CID000132904
Disease	B cell deficiency (implicated_via_orthology)	TOP2A TOP2B	9.00e-06	2	89	2	DOID:2115 (implicated_via_orthology)
Disease	acute myeloid leukemia (implicated_via_orthology)	TOP2A TOP2B	5.82e-04	12	89	2	DOID:9119 (implicated_via_orthology)
Disease	QRS duration, response to sulfonylurea	DOCK9 ZNF638	2.18e-03	23	89	2	EFO_0005055, EFO_0007922
Disease	Sensorineural Hearing Loss (disorder)	DMXL2 RIPOR2	2.18e-03	23	89	2	C0018784

Protein segments in the cluster

Peptide	Gene	Start	Entry
HDDVFEESEELSSDE	ERBIN	591	Q96RT1
LLESFAVEEDFEFDD	BAHCC1	1856	Q9P281
FEFDDNSSFSEEEED	BAHCC1	1866	Q9P281
DEDLDSVVVEFDDGD	BAHCC1	2006	Q9P281
EFDDSDDEEDTSAAL	ARHGEF10L	36	Q9HCE6
DEGFEDDLDLDISFE	EGFLAM	261	Q63HQ2
ADFFNDFEDLFDDDD	COPS9	41	Q8WXC6
TDQDDDEDLVDTCAF	CD302	116	Q8IX05
LNEEDDEDEDSTVFD	FAM174B	141	Q3ZCQ3
EDSDSEVSEFFDSFD	AKAP11	346	Q9UKA4
ANEDFDFDTEEKATE	ANKRD26P1	281	Q6NSI1
DSDESIHSDEEDDAF	DMXL2	2476	Q8TDJ6
DFEEESDDDDTAALL	CWC15	116	Q9P013
FADSDDDLERSSAEE	BMS1	501	Q14692
LESDEDESESEDEVF	CFAP44	1521	Q96MT7
DESESEDEVFDDSIC	CFAP44	1526	Q96MT7
EDFECLDSDDDLDFE	ECD	511	O95905
DDEDDDIDLFGSDNE	EEF1D	151	P29692
IDFDENTALDDAEEE	RCN2	131	Q14257
VDSVFNKFEDEDSDD	RBM25	691	P49756
SEEEFFECLSDTEEL	RAB3GAP1	581	Q15042
LEDFTEAAVDEDDED	APLP2	246	Q06481
KDDDFEEESFDIPDN	MGAT4C	326	Q9UBM8
ATWDFDDEAFDEISD	MYLK	1676	Q15746
DDEAFDEISDDAKDF	MYLK	1681	Q15746
EEEEFEIALADASDN	FRAS1	2761	Q86XX4
DIVAALDDDFDFDDP	LTV1	141	Q96GA3
TDSDDDDDDVIFCSE	ZBTB33	186	Q86T24
EETEFAEADQDFSDE	ATP9B	566	O43861
FLDDEAELSEEDAEY	FANCM	1511	Q8IYD8
SVSEAKFDDFEDEED	CCDC47	16	Q96A33
FDEETFEAVSDEAKD	MYLK2	501	Q9H1R3
FQFELTLEEAEEEDE	PDE4C	656	Q08493
EDSEEDFDSRFDTDD	MYO10	1146	Q9HD67
EEDIDFFEDIDSDED	MPHOSPH10	231	O00566
KESFRAFVEDSEDED	KRI1	161	Q8N9T8
VEEEFEDEDFLSAVE	HROB	11	Q8N3J3
DSDESSDDEFFDAHE	PITPNM2	336	Q9BZ72
SDDEFFDAHEDLSDT	PITPNM2	341	Q9BZ72
SDEDDENEFFDAPEI	OSBP	351	P22059
EEEEEDEAAAAAAAA	PEG3	1356	Q9GZU2
DDEFDDEAPEELTFA	NOL7	56	Q9UMY1
SEDFSDDFIDIEDSN	CCSER2	411	Q9H7U1
EREDTDSFEDLEADE	FRMD3	476	A2A2Y4
DEELDSEEFDSDEEL	CCDC82	41	Q8N4S0
SEEFDSDEELDSDES	CCDC82	46	Q8N4S0
SDEELDSDESFENDE	CCDC82	51	Q8N4S0
MEEFDSEDFSTSEED	CFDP1	1	Q9UEE9
EEKDETDEFFEECIT	HYDIN	356	Q4G0P3
SFEIDHEDADKDEDT	DOCK10	151	Q96BY6
FTDSETDVEGFFEDE	DOCK9	1796	Q9BZ29
EELDDSDFETEDFDV	CTNNA1	636	P35221
NTFEFADAEEDDEVK	CDC42EP1	376	Q00587
EFDEFVNDDTDDDLP	CTR9	916	Q6PD62
ETFFFGDEEEDEDEA	CUL9	2501	Q8IWT3
TQFLDRDEEEEDADF	DDX10	621	Q13206
IDLFGSDDEEESEEA	EEF1B2	101	P24534
EDDDLDVESDFDDAS	CHD4	311	Q14839
DSESDFSDDFSDDFV	RSF1	1186	Q96T23
SFLLFDDESDGEEEE	IPO4	631	Q8TEX9
DEEFEELIDTFEDDN	CEBPZ	841	Q03701
FLFKEEEEFTTDEAD	PRIMPOL	471	Q96LW4
TDEVVLEDDDFFTGE	OTOF	1741	Q9HC10
EDEDDFDDTLVAIDT	HNRNPUL1	201	Q9BUJ2
TDFEDLEDGEDLFTS	SNX2	16	O60749
FLESAAADFSDEDED	STRN	236	O43815
SDEDEDSDLEEFVRS	UVSSA	281	Q2YD98
VVSDFDSDEEQDERE	SMARCA2	1566	P51531
TFDFSEEEDDDADDD	TOP2B	1371	Q02880
EEFEDSLATDDFLVD	RGS22	16	Q8NE09
EDEEDSEDFHSIAGD	TAF1	1851	P21675
FFEDSEDESDEAEEE	PPM1G	256	O15355
FLNTSDFDEEEDGDE	RIPOR2	666	Q9Y4F9
EEEEDVAEEFDSNAS	SSRP1	486	Q08945
QAADSDDEDLDDLFV	NCAPH	566	Q15003
ESFAFVDEDEDEDLS	CLCN1	706	P35523
SFDDRLEDDDFDLIE	SUPT6H	91	Q7KZ85
DEESDIDDFIVDDDG	SUPT6H	176	Q7KZ85
LPSVSEDDSEEEFFD	VPS13A	831	Q96RL7
GDDDEVDDFEDFIFS	PBXIP1	676	Q96AQ6
DSDRAEASDCDEFED	SPIDR	131	Q14159
FYEDSDSEDEIEDLT	RIPPLY2	111	Q5TAB7
LSFTSAEDDEDDEDE	SNX21	61	Q969T3
LEDETEDDDLFETEF	XRN1	416	Q8IZH2
FDFDETIVDENSDDS	PHOSPHO1	31	Q8TCT1
DSEGFEDSFEEEEEE	SEC63	741	Q9UGP8
GLFDDEDEESDLFTE	WASHC2C	366	Q9Y4E1
SLRDFVDDDDDDDLE	VIPAS39	41	Q9H9C1
DEDKTFDESDFDDEA	PBK	256	Q96KB5
DSVESSDDEFFDARE	PITPNM3	26	Q9BZ71
DSDEDFSDFDEKTDD	TOP2A	1331	P11388
FSDFDEKTDDEDFVP	TOP2A	1336	P11388
GLFDDEDEESDLFTE	WASHC2A	366	Q641Q2
EVDADAADAAAAEEE	YIPF3	61	Q9GZM5
DHEEEDDEDFLAEVA	ZNF316	246	A6NFI3
VEYSDSEDDSEFDEV	WASF1	541	Q92558
SDTEDEVDSDFDIDE	VPS72	51	Q15906
DDSIADFLNSDEEED	ZNHIT3	71	Q15649
LDEVTEEDEDSLADF	ZNF638	1751	Q14966
FSSAARDDEVSEDEE	TYSND1	161	Q2T9J0
EDFYDSDDDTFLDRT	SLC4A1AP	461	Q9BWU0