Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	symmetric, GABA-ergic, inhibitory synapse	NLGN4Y NLGN4X	2.32e-04	4	131	2	GO:0098983
GeneOntologyCellularComponent	glycinergic synapse	GPHN NLGN4Y NLGN4X	2.54e-04	20	131	3	GO:0098690
Domain	HECT	ITCH WWP1 NEDD4 HECW2	3.37e-05	27	129	4	PF00632
Domain	HECTc	ITCH WWP1 NEDD4 HECW2	3.37e-05	27	129	4	SM00119
Domain	HECT_dom	ITCH WWP1 NEDD4 HECW2	3.37e-05	27	129	4	IPR000569
Domain	HECT	ITCH WWP1 NEDD4 HECW2	3.37e-05	27	129	4	PS50237
Domain	NLGN4	NLGN4Y NLGN4X	4.73e-05	2	129	2	IPR030025
Domain	ATM/Tel1	SMG1 ATM	4.73e-05	2	129	2	IPR015519
Domain	C8	VWF MUC5B MUC6	6.77e-05	12	129	3	PF08742
Domain	TIL	VWF MUC5B MUC6	6.77e-05	12	129	3	PF01826
Domain	Unchr_dom_Cys-rich	VWF MUC5B MUC6	8.75e-05	13	129	3	IPR014853
Domain	C8	VWF MUC5B MUC6	8.75e-05	13	129	3	SM00832
Domain	TIL_dom	VWF MUC5B MUC6	1.11e-04	14	129	3	IPR002919
Domain	PI3/4_kinase_CS	SMG1 PIK3CA ATM	1.38e-04	15	129	3	IPR018936
Domain	VWF_type-D	VWF MUC5B MUC6	1.69e-04	16	129	3	IPR001846
Domain	-	SMG1 PIK3CA ATM	1.69e-04	16	129	3	1.10.1070.11
Domain	VWFD	VWF MUC5B MUC6	1.69e-04	16	129	3	PS51233
Domain	PI3Kc	SMG1 PIK3CA ATM	1.69e-04	16	129	3	SM00146
Domain	VWD	VWF MUC5B MUC6	1.69e-04	16	129	3	SM00216
Domain	VWD	VWF MUC5B MUC6	1.69e-04	16	129	3	PF00094
Domain	VWF_dom	VWF MUC5B THBS1 MUC6	1.98e-04	42	129	4	IPR001007
Domain	PI3_PI4_kinase	SMG1 PIK3CA ATM	2.43e-04	18	129	3	PF00454
Domain	PI3_4_KINASE_1	SMG1 PIK3CA ATM	2.43e-04	18	129	3	PS00915
Domain	PI3_4_KINASE_2	SMG1 PIK3CA ATM	2.43e-04	18	129	3	PS00916
Domain	PI3/4_kinase_cat_dom	SMG1 PIK3CA ATM	2.43e-04	18	129	3	IPR000403
Domain	PI3_4_KINASE_3	SMG1 PIK3CA ATM	2.43e-04	18	129	3	PS50290
Domain	VWC_out	VWF MUC5B MUC6	2.88e-04	19	129	3	SM00215
Domain	WW	ITCH WWP1 NEDD4 HECW2	3.08e-04	47	129	4	PF00397
Domain	WW	ITCH WWP1 NEDD4 HECW2	3.34e-04	48	129	4	SM00456
Domain	C2	ITCH WWP1 NEDD4 PIK3CA HECW2 PLCL1	3.79e-04	137	129	6	SM00239
Domain	WW_DOMAIN_1	ITCH WWP1 NEDD4 HECW2	4.22e-04	51	129	4	PS01159
Domain	WW_DOMAIN_2	ITCH WWP1 NEDD4 HECW2	4.22e-04	51	129	4	PS50020
Domain	CT	VWF MUC5B MUC6	4.50e-04	22	129	3	SM00041
Domain	WW_dom	ITCH WWP1 NEDD4 HECW2	4.55e-04	52	129	4	IPR001202
Domain	C2	ITCH WWP1 NEDD4 PIK3CA HECW2 PLCL1	4.59e-04	142	129	6	PS50004
Domain	Nlgn	NLGN4Y NLGN4X	4.67e-04	5	129	2	IPR000460
Domain	FATC	SMG1 ATM	4.67e-04	5	129	2	PF02260
Domain	-	ITCH WWP1 NEDD4 PIK3CA HECW2 PLCL1	5.72e-04	148	129	6	2.60.40.150
Domain	ARM-type_fold	IPO5 SMG1 ZNFX1 CUL7 PIK3CA NUP188 ATM CTNND1 HTT	5.85e-04	339	129	9	IPR016024
Domain	Cys_knot_C	VWF MUC5B MUC6	6.62e-04	25	129	3	IPR006207
Domain	CTCK_2	VWF MUC5B MUC6	6.62e-04	25	129	3	PS01225
Domain	FAT	SMG1 ATM	6.97e-04	6	129	2	PS51189
Domain	FATC	SMG1 ATM	6.97e-04	6	129	2	PS51190
Domain	FATC_dom	SMG1 ATM	6.97e-04	6	129	2	IPR003152
Domain	PIK_FAT	SMG1 ATM	6.97e-04	6	129	2	IPR014009
Domain	FATC	SMG1 ATM	6.97e-04	6	129	2	SM01343
Domain	THIOL_PROTEASE_CYS	CTSF CAPN2 CAPN10	7.45e-04	26	129	3	PS00139
Domain	THIOL_PROTEASE_ASN	CTSF CAPN2 CAPN10	8.34e-04	27	129	3	PS00640
Domain	THIOL_PROTEASE_HIS	CTSF CAPN2 CAPN10	8.34e-04	27	129	3	PS00639
Domain	Pept_cys_AS	CTSF CAPN2 CAPN10	9.29e-04	28	129	3	IPR000169
Domain	VWC	VWF MUC5B THBS1	9.29e-04	28	129	3	PF00093
Domain	C2_dom	ITCH WWP1 NEDD4 PIK3CA HECW2 PLCL1	9.78e-04	164	129	6	IPR000008
Domain	VWFC_1	VWF MUC5B THBS1	1.95e-03	36	129	3	PS01208
Domain	C2	ITCH WWP1 NEDD4 HECW2 PLCL1	2.16e-03	131	129	5	PF00168
Domain	VWFC_2	VWF MUC5B THBS1	2.28e-03	38	129	3	PS50184
Domain	VWC	VWF MUC5B THBS1	2.28e-03	38	129	3	SM00214
Domain	XK-related	XKR8 XKR3	2.50e-03	11	129	2	PF09815
Domain	XK_rel	XKR8 XKR3	2.50e-03	11	129	2	IPR018629
Domain	calpain_III	CAPN2 CAPN10	2.99e-03	12	129	2	SM00720
Domain	C2_III	CAPN2 CAPN10	2.99e-03	12	129	2	IPR033883
Domain	Calpain_III	CAPN2 CAPN10	2.99e-03	12	129	2	IPR022683
Domain	Carboxylesterase_B_CS	NLGN4Y NLGN4X	3.51e-03	13	129	2	IPR019819
Domain	Calpain_III	CAPN2 CAPN10	3.51e-03	13	129	2	PF01067
Domain	Calpain_domain_III	CAPN2 CAPN10	3.51e-03	13	129	2	IPR022682
Domain	CARBOXYLESTERASE_B_2	NLGN4Y NLGN4X	4.08e-03	14	129	2	PS00941
Domain	COesterase	NLGN4Y NLGN4X	4.08e-03	14	129	2	PF00135
Domain	Calpain_cysteine_protease	CAPN2 CAPN10	4.08e-03	14	129	2	IPR022684
Domain	CarbesteraseB	NLGN4Y NLGN4X	4.08e-03	14	129	2	IPR002018
Domain	Peptidase_C2	CAPN2 CAPN10	4.69e-03	15	129	2	PF00648
Domain	CysPc	CAPN2 CAPN10	4.69e-03	15	129	2	SM00230
Domain	Peptidase_C2_calpain_cat	CAPN2 CAPN10	4.69e-03	15	129	2	IPR001300
Domain	CALPAIN_CAT	CAPN2 CAPN10	4.69e-03	15	129	2	PS50203
Domain	LH2	PKD1L3 ALOX15B	6.74e-03	18	129	2	SM00308
Domain	CTCK_1	VWF MUC5B	6.74e-03	18	129	2	PS01185
Pathway	REACTOME_SIGNALING_BY_ERBB4	ITCH HBEGF WWP1 NEDD4 PIK3CA	3.29e-06	33	100	5	MM14523
Pathway	PID_ERBB4_PATHWAY	ITCH HBEGF WWP1 NEDD4 PIK3CA	6.77e-06	38	100	5	M13
Pathway	REACTOME_DOWNREGULATION_OF_ERBB4_SIGNALING	ITCH WWP1 NEDD4	2.82e-05	9	100	3	M26930
Pathway	REACTOME_DOWNREGULATION_OF_ERBB4_SIGNALING	ITCH WWP1 NEDD4	2.82e-05	9	100	3	MM14535
Pathway	REACTOME_SIGNALING_BY_ERBB4	ITCH HBEGF WWP1 NEDD4 PIK3CA	5.52e-05	58	100	5	M544
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	GALNT10 TPRA1 ITCH UBE4B NLGN4Y BICRA WWP1 TRPM2 TMC6 STAP2 TEP1 NPLOC4 HPS3 KLK4 JOSD2 SH3PXD2A USP40 SHPRH KNDC1 CHD6 GNAS CTNND1 RECK HTT	1.91e-09	1489	132	24	28611215
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ENGASE TPRA1 UBE4B BICRA WWP1 PIEZO1 TMC6 NSD1 TEP1 TBC1D16 TMEM129 CDK5R1 AATK NFKB2 A4GALT USP40 C19orf44 NUP188 ABCC10 HTT	7.43e-09	1105	132	20	35748872
Pubmed	Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.	TRPM2 PKD1L3 GFI1	2.13e-07	4	132	3	27196058
Pubmed	The Ubiquitin Ligase Itch and Ubiquitination Regulate BFRF1-Mediated Nuclear Envelope Modification for Epstein-Barr Virus Maturation.	ITCH WWP1 NEDD4	2.13e-07	4	132	3	27466427
Pubmed	A Tunable Brake for HECT Ubiquitin Ligases.	ITCH WWP1 NEDD4	5.31e-07	5	132	3	28475870
Pubmed	SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.	ITCH WWP1 NEDD4 HECW2	7.35e-07	19	132	4	21572392
Pubmed	Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.	ITCH WWP1 NEDD4 HECW2	1.13e-06	21	132	4	37005481
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	ITCH WWP1 NEDD4 HECW2	2.78e-06	26	132	4	26949039
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	ITCH WWP1 CUL7 NEDD4 LLGL1 HECW2 ATM GNAS CTNND1	3.33e-06	313	132	9	38270169
Pubmed	Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.	ITCH WWP1 NEDD4	6.29e-06	10	132	3	25092867
Pubmed	Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.	ITCH WWP1 NEDD4	8.62e-06	11	132	3	17996703
Pubmed	Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding.	ITCH WWP1 NEDD4	8.62e-06	11	132	3	21191027
Pubmed	USP11 augments TGFβ signalling by deubiquitylating ALK5.	ITCH WWP1 NEDD4	8.62e-06	11	132	3	22773947
Pubmed	Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.	ITCH WWP1 NEDD4	8.62e-06	11	132	3	25963657
Pubmed	NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.	ITCH WWP1 NEDD4	1.15e-05	12	132	3	24107629
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	GPHN DMXL2 UBE4B NLGN4Y NEDD4 NLGN4X PLCL1 GNAS	1.27e-05	281	132	8	28706196
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	IPO5 CAPN2 CUL7 THBS1 ZNF644 NIP7 CHD6 CTNND1	1.31e-05	282	132	8	23667531
Pubmed	Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1.	THBS1 HRG	1.43e-05	2	132	2	11134179
Pubmed	SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress.	SMG1 ATM	1.43e-05	2	132	2	31565865
Pubmed	Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.	ATM HTT	1.43e-05	2	132	2	25540325
Pubmed	A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.	KAT5 ATM	1.43e-05	2	132	2	16141325
Pubmed	hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress.	SMG1 ATM	1.43e-05	2	132	2	18332866
Pubmed	Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.	NLGN4Y NLGN4X	1.43e-05	2	132	2	23183221
Pubmed	Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.	NLGN4Y NLGN4X	1.43e-05	2	132	2	24855039
Pubmed	Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder.	NLGN4Y NLGN4X	1.43e-05	2	132	2	37001827
Pubmed	ATM kinase activity modulates ITCH E3-ubiquitin ligase activity.	ITCH ATM	1.43e-05	2	132	2	23435430
Pubmed	Role of thrombospondin-1 in control of von Willebrand factor multimer size in mice.	VWF THBS1	1.43e-05	2	132	2	14981081
Pubmed	Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.	ATM HTT	1.43e-05	2	132	2	28017939
Pubmed	Human cytomegalovirus UL42 protein inhibits the degradation of glycoprotein B through inhibition of Nedd4 family ubiquitin E3 ligases.	ITCH NEDD4	1.43e-05	2	132	2	34260096
Pubmed	Heparin-binding epidermal growth factor-like growth factor inhibits cytokine-induced NF-kappa B activation and nitric oxide production via activation of the phosphatidylinositol 3-kinase pathway.	HBEGF PIK3CA	1.43e-05	2	132	2	16034135
Pubmed	Thrombospondin 1 requires von Willebrand factor to modulate arterial thrombosis in mice.	VWF THBS1	1.43e-05	2	132	2	25343959
Pubmed	Mutations of the Huntington's disease protein impact on the ATM-dependent signaling and repair pathways of the radiation-induced DNA double-strand breaks: corrective effect of statins and bisphosphonates.	ATM HTT	1.43e-05	2	132	2	24277524
Pubmed	Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation.	PIK3CA ATM	1.43e-05	2	132	2	16728507
Pubmed	Relationship between thrombospondin gene variations, von Willebrand factor levels and the risk of coronary heart disease in an older population.	VWF THBS1	1.43e-05	2	132	2	21518247
Pubmed	Holliday junction recognition protein interacts with and specifies the centromeric assembly of CENP-T.	CENPT HJURP	1.43e-05	2	132	2	30459232
Pubmed	Suppression of cell migration by phospholipase C-related catalytically inactive protein-dependent modulation of PI3K signalling.	PIK3CA PLCL1	1.43e-05	2	132	2	28710365
Pubmed	Thrombospondin-1 in von Willebrand factor function.	VWF THBS1	1.43e-05	2	132	2	18855616
Pubmed	Unusually rapid evolution of Neuroligin-4 in mice.	NLGN4Y NLGN4X	1.43e-05	2	132	2	18434543
Pubmed	UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis.	ITCH UBE4B	1.43e-05	2	132	2	37957138
Pubmed	Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice.	NLGN4Y NLGN4X	1.43e-05	2	132	2	37080762
Pubmed	Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex.	NLGN4Y NLGN4X	1.43e-05	2	132	2	29106499
Pubmed	Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.	NLGN4Y NLGN4X	1.43e-05	2	132	2	26456829
Pubmed	ATM and KAT5 safeguard replicating chromatin against formaldehyde damage.	KAT5 ATM	1.43e-05	2	132	2	26420831
Pubmed	Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro.	NLGN4Y NLGN4X	1.43e-05	2	132	2	24104404
Pubmed	A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.	NLGN4Y NLGN4X	1.43e-05	2	132	2	32243781
Pubmed	Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.	NLGN4Y NLGN4X	1.43e-05	2	132	2	22989184
Pubmed	Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.	GPHN NLGN4Y NLGN4X	2.35e-05	15	132	3	18227507
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SMG1 DMXL2 DICER1 AATK RAB3GAP2 CACNA1G CHD6	2.57e-05	225	132	7	12168954
Pubmed	RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.	ITCH WWP1 NEDD4	3.50e-05	17	132	3	28292929
Pubmed	Wilms Tumor Predisposition	DIS3L2 NSD1 DICER1	4.18e-05	18	132	3	20301471
Pubmed	Association between variations in coagulation system genes and carotid plaque.	VWF THBS1	4.28e-05	3	132	2	22982001
Pubmed	Thrombospondin-1 and ADAMTS13 competitively bind to VWF A2 and A3 domains in vitro.	VWF THBS1	4.28e-05	3	132	2	20705333
Pubmed	Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases.	ITCH WWP1	4.28e-05	3	132	2	12450395
Pubmed	Ubiquitylation of a melanosomal protein by HECT-E3 ligases serves as sorting signal for lysosomal degradation.	ITCH NEDD4	4.28e-05	3	132	2	15703212
Pubmed	Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration: the role of p25/cyclin-dependent kinase 5.	CDK5R1 HTT	4.28e-05	3	132	2	18829967
Pubmed	Thymidylate kinase is critical for DNA repair via ATM-dependent Tip60 complex formation.	KAT5 ATM	4.28e-05	3	132	2	30199284
Pubmed	Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator.	THBS1 HRG	4.28e-05	3	132	2	6438154
Pubmed	Prostate Cancer-Associated Kallikrein-Related Peptidase 4 Activates Matrix Metalloproteinase-1 and Thrombospondin-1.	THBS1 KLK4	4.28e-05	3	132	2	27378148
Pubmed	Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.	NLGN4Y NLGN4X	4.28e-05	3	132	2	32011705
Pubmed	Evaluating von Willebrand factor and ADAMTS13 levels in thalassemia major patients and assessing a possible association with Thrombospondin-1.	VWF THBS1	4.28e-05	3	132	2	37438087
Pubmed	Ubiquitin ligase ITCH recruitment suppresses the aggregation and cellular toxicity of cytoplasmic misfolded proteins.	ITCH HTT	4.28e-05	3	132	2	24865853
Pubmed	Predictive Value of the TP53/PIK3CA/ATM Mutation Classifier for Patients With Bladder Cancer Responding to Immune Checkpoint Inhibitor Therapy.	PIK3CA ATM	4.28e-05	3	132	2	34421886
Pubmed	P-selectin can promote thrombus propagation independently of both von Willebrand factor and thrombospondin-1 in mice.	VWF THBS1	4.28e-05	3	132	2	27943541
Pubmed	Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein.	WWP1 NEDD4	4.28e-05	3	132	2	11779188
Pubmed	Analysis of the neuroligin 4Y gene in patients with autism.	NLGN4Y NLGN4X	4.28e-05	3	132	2	18628683
Pubmed	p120-Catenin Downregulation and PIK3CA Mutations Cooperate to Induce Invasion through MMP1 in HNSCC.	PIK3CA CTNND1	4.28e-05	3	132	2	28637905
Pubmed	Thrombospondin-1 Regulates Trophoblast Necroptosis via NEDD4-Mediated Ubiquitination of TAK1 in Preeclampsia.	NEDD4 THBS1	4.28e-05	3	132	2	38569496
Pubmed	The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.	KAT5 ATM	4.28e-05	3	132	2	16603769
Pubmed	Neurotoxicity induces cleavage of p35 to p25 by calpain.	CAPN2 CDK5R1	4.28e-05	3	132	2	10830966
Pubmed	The Vif protein of human immunodeficiency virus type 1 is posttranslationally modified by ubiquitin.	ITCH NEDD4	4.28e-05	3	132	2	15013426
Pubmed	The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways.	SMG1 ATM	4.28e-05	3	132	2	15279777
Pubmed	Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.	NLGN4Y NLGN4X	4.28e-05	3	132	2	21282647
Pubmed	Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth.	THBS1 HRG	4.28e-05	3	132	2	22808089
Pubmed	ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.	ITCH WWP1 NEDD4	6.76e-05	21	132	3	29416926
Pubmed	Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled.	ITCH WWP1	8.54e-05	4	132	2	26701932
Pubmed	Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.	KAT5 ATM	8.54e-05	4	132	2	19783983
Pubmed	Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.	MUC5B MUC6	8.54e-05	4	132	2	23807779
Pubmed	RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions.	DUT THBS1	8.54e-05	4	132	2	10087292
Pubmed	GLTSCR1, ATM, PPP1R13L and CD3EAP Genetic Variants and Lung Cancer Risk in a Chinese Population.	BICRA ATM	8.54e-05	4	132	2	30128886
Pubmed	Hypoxia-induced Nur77 activates PI3K/Akt signaling via suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition.	DICER1 PIK3CA	8.54e-05	4	132	2	33537093
Pubmed	The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.	SMG1 ATM	8.54e-05	4	132	2	15175154
Pubmed	HJURP involvement in de novo CenH3(CENP-A) and CENP-C recruitment.	CENPT HJURP	8.54e-05	4	132	2	25843710
Pubmed	Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.	NEDD4 PIK3CA	8.54e-05	4	132	2	25879670
Pubmed	WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response.	ITCH ATM	8.54e-05	4	132	2	25331887
Pubmed	NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex.	KAT5 ATM	8.54e-05	4	132	2	27524627
Pubmed	The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.	NEDD4 THBS1	8.54e-05	4	132	2	20026598
Pubmed	MGRN1-dependent pigment-type switching requires its ubiquitination activity but not its interaction with TSG101 or NEDD4.	ITCH NEDD4	8.54e-05	4	132	2	23253940
Pubmed	Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5.	ITCH WWP1	8.54e-05	4	132	2	19580544
Pubmed	Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.	NLGN4Y NLGN4X	8.54e-05	4	132	2	12669065
Pubmed	Homodimerization and isoform-specific heterodimerization of neuroligins.	NLGN4Y NLGN4X	8.54e-05	4	132	2	22671294
Pubmed	Ultrasonic vocalizations in mouse models for speech and socio-cognitive disorders: insights into the evolution of vocal communication.	NLGN4Y NLGN4X	8.54e-05	4	132	2	20579107
Pubmed	Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens.	CAPN2 CAPN10	8.54e-05	4	132	2	12634108
Pubmed	Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.	MUC5B MUC6	8.54e-05	4	132	2	17471237
Pubmed	A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.	THBS1 RAPGEF3	8.54e-05	4	132	2	19710505
Pubmed	The mouse secreted gel-forming mucin gene cluster.	MUC5B MUC6	8.54e-05	4	132	2	14984930
Pubmed	The ubiquitin-protein ligase Itch regulates p73 stability.	ITCH NEDD4	8.54e-05	4	132	2	15678106
Pubmed	Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin43.	ITCH NEDD4	8.54e-05	4	132	2	20522958
Pubmed	Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.	MUC5B MUC6	8.54e-05	4	132	2	29869461
Pubmed	Polymorphisms in MUC1, MUC2, MUC5B and MUC6 genes are not associated with the risk of chronic atrophic gastritis.	MUC5B MUC6	8.54e-05	4	132	2	21596555
Pubmed	Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein.	CDK5R1 AATK	8.54e-05	4	132	2	14521924
Interaction	PRRG1 interactions	ITCH WWP1 NEDD4 DCAF10 HECW2	2.32e-08	15	124	5	int:PRRG1
Interaction	ILDR1 interactions	ITCH WWP1 NEDD4 HECW2	4.36e-07	11	124	4	int:ILDR1
Interaction	TOP3B interactions	IPO5 ENGASE TPRA1 UBE4B BICRA WWP1 PIEZO1 TMC6 NSD1 TEP1 TBC1D16 TMEM129 CDK5R1 AATK FASTK TRIM56 NFKB2 A4GALT USP40 C19orf44 NUP188 GNAS ZNF598 ABCC10 HTT	2.80e-06	1470	124	25	int:TOP3B
Interaction	LDLRAD3 interactions	ITCH WWP1 NEDD4	7.82e-06	7	124	3	int:LDLRAD3
Interaction	FBXL15 interactions	ITCH WWP1 NEDD4 HECW2	2.88e-05	29	124	4	int:FBXL15
Cytoband	17q25.3	ENGASE TMC6 TBC1D16 AATK	2.15e-04	101	132	4	17q25.3
Cytoband	11p15.4	OR51S1 MRGPRG OR56A5 DCHS1 OR56B4	2.95e-04	200	132	5	11p15.4
GeneFamily	Olfactory receptors, family 56	OR56A5 OR56B4	7.17e-04	9	82	2	167
GeneFamily	Blood group antigens\|XK related family	XKR8 XKR3	1.09e-03	11	82	2	955
Coexpression	GSE15330_LYMPHOID_MULTIPOTENT_VS_GRANULOCYTE_MONOCYTE_PROGENITOR_IKAROS_KO_UP	GPHN TPRA1 TMC6 DUT NFKB2 SHPRH NUP188 ATM	6.80e-06	198	130	8	M7046
Disease	Sex Cord-Stromal Tumor	DICER1 GNAS	1.90e-05	2	129	2	C0206724
Disease	cancer (implicated_via_orthology)	IPO5 KAT5 DUT DHDDS LLGL1 ATM TBX2	1.84e-04	268	129	7	DOID:162 (implicated_via_orthology)
Disease	mean reticulocyte volume	ADGRG5 RETREG2 PIEZO1 BACH2 TMC6 NPLOC4 HPS3 TBC1D16 PIK3CA VPS13A ATM ABCC10	2.08e-04	799	129	12	EFO_0010701
Disease	hepatocyte growth factor activator measurement	DOK7 HTT	3.93e-04	7	129	2	EFO_0008152
Disease	arachidonate 15-lipoxygenase B measurement	GFI1 ALOX15B	3.93e-04	7	129	2	EFO_0801391
Disease	Pituitary Adenoma	DICER1 GNAS	6.69e-04	9	129	2	C0032000
Disease	obsolete_red blood cell distribution width	KAT5 PIEZO1 TMC6 DHDDS DCK GFI1 NPLOC4 TRMU HECW2 TRIM56 A4GALT MCUR1 VPS13A OR6Y1 SLC22A31	8.20e-04	1347	129	15	EFO_0005192
Disease	rheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement	TPRA1 BACH2 ZNF629 GFI1 PLCL1	9.26e-04	170	129	5	EFO_0000685, EFO_0007791, EFO_0007837
Disease	Neuroblastoma	CHD6 GNAS TBX2	1.15e-03	47	129	3	C0027819
Disease	lymphocyte measurement	PIEZO1 BACH2 TMC6 ZNF629	1.77e-03	117	129	4	EFO_0803546
Disease	Adenocarcinoma of lung (disorder)	IPO5 AATK PIK3CA FASTK ATM	2.16e-03	206	129	5	C0152013
Disease	Acute Myeloid Leukemia, M1	BACH2 CAPN2 NSD1 GFI1	2.25e-03	125	129	4	C0026998
Disease	Acute Myeloid Leukemia (AML-M2)	BACH2 CAPN2 NSD1 GFI1	2.25e-03	125	129	4	C1879321
Disease	Malignant Neoplasms	DICER1 PIK3CA ATM GNAS	2.45e-03	128	129	4	C0006826
Disease	Benign neoplasm of stomach	PIK3CA ATM	2.47e-03	17	129	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	PIK3CA ATM	2.47e-03	17	129	2	C0496905
Disease	Carcinoma in situ of stomach	PIK3CA ATM	2.47e-03	17	129	2	C0154060
Disease	cholangiocarcinoma (is_marker_for)	MUC5B THBS1 MUC6	2.80e-03	64	129	3	DOID:4947 (is_marker_for)
Disease	hip bone size	A4GALT PLCL1 ENTPD8	2.93e-03	65	129	3	EFO_0004844
Disease	anorectal malformation	TRPM2 MUC5B	3.09e-03	19	129	2	MONDO_0019938
Disease	platelet crit	ADGRG5 VWF KAT5 RETREG2 PIEZO1 BACH2 TMC6 THBS1 A4GALT DCHS1 ABCC10	3.13e-03	952	129	11	EFO_0007985
Disease	Profound Mental Retardation	NSD1 CAPN10 CACNA1G GNAS	3.29e-03	139	129	4	C0020796
Disease	Mental Retardation, Psychosocial	NSD1 CAPN10 CACNA1G GNAS	3.29e-03	139	129	4	C0025363
Disease	Mental deficiency	NSD1 CAPN10 CACNA1G GNAS	3.29e-03	139	129	4	C0917816
Disease	Intellectual Disability	NSD1 CAPN10 FCSK MED12L CACNA1G GNAS HTT	3.59e-03	447	129	7	C3714756
Disease	BREAST CANCER	PIK3CA ATM	3.77e-03	21	129	2	114480
Disease	Stomach Carcinoma	PIK3CA ATM	3.77e-03	21	129	2	C0699791
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	VWF TRIM56	3.77e-03	21	129	2	EFO_0004286, EFO_0004792
Disease	cholangiocarcinoma (is_implicated_in)	THBS1 GNAS	4.14e-03	22	129	2	DOID:4947 (is_implicated_in)
Disease	Granulomatous Slack Skin	NFKB2 ATM	4.14e-03	22	129	2	C0376407
Disease	rheumatoid arthritis	TPRA1 BACH2 ZNF629 GFI1 NEDD4 SH3PXD2A PLCL1	4.29e-03	462	129	7	EFO_0000685

Protein segments in the cluster

Peptide	Gene	Start	Entry
RIYHLNRNIDLFPPC	TDRD1	361	Q9BXT4
YLTAPDLARCPAQRA	ACOX2	476	Q99424
EQIQALHRYCPVLRP	BACH2	721	Q9BYV9
YCPLREPHRTLNFLA	CCDC116	291	Q8IYX3
RLQCPRVDLFYLHAP	AKR7L	101	Q8NHP1
RRCYRLKHLSPTDPV	CDK5R1	161	Q15078
RALLAQLHARYCPTT	A4GALT	331	Q9NPC4
RPELLCSFRHPGLYQ	EVX2	331	Q03828
PDPGRLLCQTRHERY	ACOT2	176	P49753
LLCQTRHERYFLPPG	ACOT2	181	P49753
YTERLLCHTRALPGA	CAPN10	331	Q9HC96
LQEPLLSCVPHRYAQ	CAPN10	596	Q9HC96
HRYAQEVSRLCLLPA	CAPN10	606	Q9HC96
HTCLLTSLPPLYRVQ	DMXL2	1576	Q8TDJ6
IGHINRYCARLPSDP	DICER1	631	Q9UPY3
SDHRVPRIYVPLKDC	DIS3L2	271	Q8IYB7
LHREYCLSPRNQPRR	HJURP	441	Q8NCD3
QQSPPLCHDYELRVL	MUC5B	1411	Q9HC84
PSCYIPLRRLQDLAS	NSD1	66	Q96L73
SRLKHLLQRAPDYCP	RECK	61	O95980
LSCDVKLDPRPEYHR	GPHN	661	Q9NQX3
LSVRHPEYNRPLLAN	KLK4	101	Q9Y5K2
YQRKSPVLARCTLHP	LLGL1	626	Q15334
RAHTCFNRLDLPPYP	HECW2	1536	Q9P2P5
LQLKCRTYEIPRHPG	RAB3GAP2	186	Q9H2M9
SCPRFLRYPRQHLIS	FASTK	211	Q14296
CRPLHSYEQQLELPC	MUC6	2396	Q6W4X9
DICRLPHRLQPTYLA	ABCC10	246	Q5T3U5
AAPLIRAERPHYVLT	DCHS1	1276	Q96JQ0
HCRQIGSVYRLPPLR	HRG	451	P04196
YHGPAPALVSCRREL	MCUR1	126	Q96AQ8
VLRRYHSCLILNPDQ	MED12L	886	Q86YW9
PRAHTCFNRLDLPPY	NEDD4	1281	P46934
DLRHLVQSYRPCGAL	GFI1	131	Q99684
RCAASPYLRPLTLHY	NUDT14	11	O95848
VAPRTDHPALYRDLL	TRMU	291	O75648
VQSRPAALLRHPCYL	ENTPD8	261	Q5MY95
RHPNCNSKRYLETLP	GALNT10	131	Q86SR1
TKCDLRHPPGNEIYR	KAT5	281	Q92993
PPTVYHERQRLELCA	JOSD2	11	Q8TAC2
ALAICRPLHYPALLT	OR51S1	131	Q8NGJ8
HTLNPRTCLPSYLRG	CUL7	1406	Q14999
RPVSPRCSLRLTHYI	DCAF10	451	Q5QP82
SRFRVPLLHCDLINP	RNASE3	101	P12724
IYRSRDPQLCRHGPL	NPLOC4	121	Q8TAT6
PLLLSRDPAQYCHAV	LMLN2	111	A0A1B0GTW7
RSLAHPERPQLCRYD	LIPH	416	Q8WWY8
EVLRHPECNLRYLGL	NLRP2	776	Q9NX02
RCPAPARLDVHALYT	AP5B1	731	Q2VPB7
PRPALCYHFLTSLLR	DUT	6	P33316
LFLQDPHPRVRYAAC	IPO5	406	O00410
IYIPDLPRAARLCLS	PIK3CA	391	P42336
RTLLPQRCGYTILHL	MARCHF9	306	Q86YJ5
LLCSEEPPRLHSNYQ	GPR149	216	Q86SP6
LLRNSACPLVCPRYH	MRGPRG	146	Q86SM5
PIPILSSRLRYCAGH	OR56A5	161	P0C7T3
CLRINHLGAPSPRYL	PCDHAC2	76	Q9Y5I4
LTIPVPILAAQRHYC	OR56B4	161	Q8NH76
PRSHTCFNRLDLPPY	ITCH	866	Q96J02
LQAHDTLRLTCPPDY	NLGN4Y	746	Q8NFZ3
AEYCLPSARLFPVLH	FCSK	481	Q8N0W3
QRHGERTPYVLRCLT	ATM	446	Q13315
IERYHIPRACPREVQ	FKBP10	46	Q96AY3
AELAHLVRPQKCRPY	HTT	191	P42858
APGSPYHRLLTCLRN	HTT	3121	P42858
AYIFPPQSRFRLLCH	CACNA1G	1256	O43497
PQLHERLQLCRPSLY	CHD6	1556	Q8TD26
EAKEYIRCHRPAPLT	C19orf44	631	Q9H6X5
PDVHDSVLYRLCLQP	FNDC10	136	F2Z333
ERHLPLEYRQLLIPC	CENPT	536	Q96BT3
RRARHNYNDLCPPIG	GNAS	11	O95467
FYRHGISRPLRPLCS	CTSF	411	Q9UBX1
RALQTRPEHPAYLCL	KNDC1	471	Q76NI1
RPEHPAYLCLDSVLV	KNDC1	476	Q76NI1
TPETCLHRIYLRGRN	DCK	181	P27707
LERYLPTHSICSLPF	ENGASE	386	Q8NFI3
LRAHYDTPRSLCLAP	DOK7	401	Q18PE1
ERCHGLSLPVENRLY	HBEGF	141	Q99075
HCPRLPLRKTYRENV	BICRA	1381	Q9NZM4
FLRHYSRLEICNLTP	CAPN2	331	P17655
CLYTNRSPHPDILIR	DHDDS	191	Q86SQ9
LYLARLELCDPPHRL	SLC22A31	201	A6NKX4
LQAHDTLRLTCPPDY	NLGN4X	746	Q8N0W4
CLLRNLSYQVHREIP	CTNND1	581	O60716
LLCLRYHLNLSPQRV	MFNG	21	O00587
EDPSRFRSLHCLLYP	MFNG	296	O00587
HLYCPLRLPAALQAA	FOXQ1	371	Q9C009
CEPLRYPLLLSHRVC	OR10C1	126	Q96KK4
IRRCHYLPKNFPVTD	ALOX15B	251	O15296
LERYPECGNLLLRPS	STAP2	166	Q9UGK3
RPHLQAYLCLAKARV	TMEM161A	331	Q9NX61
LLERCPEAVIPYANH	HPS3	911	Q969F9
YVPRHLCQLPSLNEL	LRRC28	171	Q86X40
GDHYPRRSLARDPLC	AATK	591	Q6ZMQ8
LLVDRPDGTYCFRLH	NIP7	26	Q9Y221
CRVAQDSPHLILYPA	SMG1	1846	Q96Q15
LAPHRPRCITKFAQY	SH2D5	16	Q6ZV89
GARPHLLSVPELCRY	RETREG2	146	Q8NC44
GLHLRRFSYICSPRP	PKD1L3	1401	Q7Z443
VCRLSLRQYQRPPHS	SPPL2C	301	Q8IUH8
LYPLLRLRQACCHPQ	SHPRH	971	Q149N8
DRHAAICRPLLYGQI	OR8S1	121	Q8NH09
IVPLLNPIIYCLRNH	OR6Y1	286	Q8NGX8
PRELRLICIYFSNTH	ADGRG5	126	Q8IZF4
FECLQPGYRHVPLRS	PLCL1	816	Q15111
PRSCSYQLLLEHQRP	RAPGEF3	51	O95398
APNISVPHRCLLLLY	TPRA1	21	Q86W33
KELANELRRPPLCYH	THBS1	306	P07996
DRYLAVCHPLRSLQQ	AVPR1B	131	P47901
FNSHLLPRPLRHLAC	AVPR1B	341	P47901
HKRIDLRPRPYVCSE	ZNF749	546	O43361
QPHVIALRRNYLPAL	VPS13A	2616	Q96RL7
HRAVSPLPYLRNCRY	VWF	596	P04275
IAAFLPACRPHLRRY	TEP1	311	Q99973
LPSLRLYEEHCKPER	TBX2	301	Q13207
THYRLPSVRLDRPCF	TRAPPC14	356	Q8WVR3
LPVAELRRPQSYGHC	KBTBD13	331	C9JR72
PIDEYCRALVRLPPH	SH3PXD2A	96	Q5TCZ1
HRPRCYLRDLQLLEA	TOMT	216	Q8WZ04
NARHLLYPNCPVTRF	TRPM2	1241	O94759
VDPTYIFHPRCRITL	UBE4B	706	O95155
YQFRLLPRIPCSLHD	TBC1D16	691	Q8TBP0
CERLPALYLARPENA	TMEM102	416	Q8N9M5
QDRYWCPPLLHRAAI	NUP188	971	Q5SRE5
CPEIARLLTPHIYQD	ZNFX1	1076	Q9P2E3
YRQLLQHECPRCPEL	ZNF598	111	Q86UK7
HLNVPRPYACRECGR	ZNF644	441	Q9H582
LLGPIVRCLHTIRNY	XKR3	106	Q5GH77
APYLCRVLAALEPHD	TMC6	486	Q7Z403
LRQLGLEHTRYPCLD	PIEZO1	501	Q92508
CHPLARTLALYALPQ	TMEM129	121	A0AVI4
RSHTCFNRLDLPPYK	WWP1	886	Q9H0M0
LPLEYRHVRLCARDA	TOR3A	336	Q9H497
LEHLRSPLGARPYRC	ZNF629	756	Q9UEG4
RANPRYGVPCHLLNE	USP40	491	Q9NVE5
EQLRAPKTLPCLHTY	TRIM56	26	Q9BRZ2
YHRALRTCLPSKPLL	XKR8	181	Q9H6D3
YILRPLASCPSLHAV	ZW10	251	O43264
HQRLLPREGPYVCSD	ZNF776	226	Q68DI1
LYPVHLAVRARSPEC	NFKB2	601	Q00653