Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionNADH oxidase H202-forming activity

DUOX2 DUOX1

2.69e-0521042GO:0106293
MousePhenoincreased circulating LDL cholesterol level

CT45A6 CT45A1 CT45A10 CT45A2 CT45A7 CT45A9 CT45A3

4.51e-0780837MP:0000182
MousePhenoincreased circulating HDL cholesterol level

CT45A6 CT45A1 CT45A10 ESR1 CT45A2 DUOX2 LRRK1 CT45A7 CT45A9 CT45A3

1.39e-062388310MP:0001556
MousePhenoabnormal circulating LDL cholesterol level

CT45A6 CT45A1 ABCA1 CT45A10 CT45A2 CT45A7 CT45A9 CT45A3

5.40e-06163838MP:0000181
MousePhenoabnormal circulating non-HDL cholesterol level

CT45A6 CT45A1 ABCA1 CT45A10 CT45A2 CT45A7 CT45A9 CT45A3

1.12e-05180838MP:0020151
MousePhenoabnormal circulating HDL cholesterol level

CT45A6 CT45A1 ABCA1 CT45A10 ESR1 CT45A2 DUOX2 LRRK1 CT45A7 CT45A9 CT45A3

8.28e-054608311MP:0000184
DomainINT_SG_DDX_CT_C

CT45A1 CT45A10 CT45A7 CT45A9 CT45A3

2.20e-1081005PF15300
DomainINT_SG_DDX_CT_C

CT45A1 CT45A10 CT45A7 CT45A9 CT45A3

2.20e-1081005IPR029307
DomainRmlC_Cupin

HGD CT45A1 CT45A2 CT45A3

1.34e-06161004IPR011051
DomainDUOX1

DUOX2 DUOX1

2.84e-0521002IPR029595
DomainV-ATPase_su_B/beta

ATP6V1B1 ATP6V1B2

2.84e-0521002IPR022879
DomainATPase_V1-cplx_bsu

ATP6V1B1 ATP6V1B2

2.84e-0521002IPR005723
Domain-

ARHGAP24 TRIO DAB2 PREX2 APPL2 NF2 ITSN2 ENAH ROCK1

2.50e-0439110092.30.29.30
DomainATP_synth_asu_C

ATP6V1B1 ATP6V1B2

2.81e-0451002IPR000793
DomainATP-synt_ab_N

ATP6V1B1 ATP6V1B2

2.81e-0451002PF02874
DomainRDM_domain_RFPL

RFPL4AL1 RFPL4A

2.81e-0451002IPR022723
DomainATPase_F1/V1/A1_a/bsu_N

ATP6V1B1 ATP6V1B2

2.81e-0451002IPR004100
DomainRDM

RFPL4AL1 RFPL4A

2.81e-0451002PF11002
DomainATPase_a/bsu_AS

ATP6V1B1 ATP6V1B2

2.81e-0451002IPR020003
DomainATP-synt_ab_C

ATP6V1B1 ATP6V1B2

2.81e-0451002PF00306
DomainATP-synt_ab

ATP6V1B1 ATP6V1B2

2.81e-0451002PF00006
DomainATPASE_ALPHA_BETA

ATP6V1B1 ATP6V1B2

2.81e-0451002PS00152
DomainATPase_F1/V1/A1_a/bsu_nucl-bd

ATP6V1B1 ATP6V1B2

4.20e-0461002IPR000194
DomainPH_dom-like

ARHGAP24 TRIO DAB2 PREX2 APPL2 NF2 ITSN2 ENAH ROCK1

4.68e-044261009IPR011993
DomainGlyco_trans_1

GLT1D1 GTDC1

5.86e-0471002IPR001296
DomainNAD_binding_6

DUOX2 DUOX1

5.86e-0471002PF08030
DomainGlycos_transf_1

GLT1D1 GTDC1

5.86e-0471002PF00534
DomainFAD_binding_8

DUOX2 DUOX1

5.86e-0471002PF08022
DomainFAD-bd_8

DUOX2 DUOX1

5.86e-0471002IPR013112
DomainFe_red_NAD-bd_6

DUOX2 DUOX1

5.86e-0471002IPR013121
DomainAn_peroxidase

DUOX2 DUOX1

1.24e-03101002PF03098
DomainHaem_peroxidase_animal

DUOX2 DUOX1

1.24e-03101002IPR019791
DomainHaem_peroxidase

DUOX2 DUOX1

1.24e-03101002IPR010255
DomainPEROXIDASE_3

DUOX2 DUOX1

1.24e-03101002PS50292
Domain-

DUOX2 DUOX1

1.24e-031010021.10.640.10
DomainPH

ARHGAP24 TRIO PREX2 APPL2 ITSN2 ROCK1

1.45e-032291006PF00169
DomainBTB-kelch_protein

KLHL2 KBTBD2 KLHL36

1.57e-03431003IPR017096
DomainFerric_reduct

DUOX2 DUOX1

1.81e-03121002PF01794
DomainFe3_Rdtase_TM_dom

DUOX2 DUOX1

1.81e-03121002IPR013130
DomainKelch

KLHL2 KBTBD2 KLHL36

3.71e-03581003SM00612
DomainPH

ARHGAP24 TRIO PREX2 APPL2 ITSN2 ROCK1

3.82e-032781006SM00233
DomainPH_DOMAIN

ARHGAP24 TRIO PREX2 APPL2 ITSN2 ROCK1

3.89e-032791006PS50003
DomainGal_Oxase/kelch_b-propeller

KLHL2 KBTBD2 KLHL36

3.90e-03591003IPR011043
DomainPH_domain

ARHGAP24 TRIO PREX2 APPL2 ITSN2 ROCK1

3.96e-032801006IPR001849
DomainBACK

KLHL2 KBTBD2 KLHL36

4.09e-03601003SM00875
DomainBACK

KLHL2 KBTBD2 KLHL36

4.28e-03611003IPR011705
DomainBACK

KLHL2 KBTBD2 KLHL36

4.28e-03611003PF07707
DomainFd_Rdtase_FAD-bd

DUOX2 DUOX1

4.57e-03191002IPR017927
DomainFAD_FR

DUOX2 DUOX1

4.57e-03191002PS51384
DomainRiboflavin_synthase-like_b-brl

DUOX2 DUOX1

4.57e-03191002IPR017938
DomainZF_DAG_PE_1

ROCK1 PRKCG UNC13C

4.90e-03641003PS00479
DomainZF_DAG_PE_2

ROCK1 PRKCG UNC13C

4.90e-03641003PS50081
DomainC1

ROCK1 PRKCG UNC13C

5.12e-03651003SM00109
DomainPE/DAG-bd

ROCK1 PRKCG UNC13C

5.34e-03661003IPR002219
Pubmed

Identification of cancer/testis-antigen genes by massively parallel signature sequencing.

CT45A6 CT45A1 CT45A10 CT45A2 CT45A7 CT45A9 CT45A8 CT45A3 CT45A5

8.62e-2015107915905330
Pubmed

Functional proteomics mapping of a human signaling pathway.

FLI1 TTF2 DAB2 PIAS2 FMNL2 EPG5 PHKA2 DCUN1D1 ROCK1 BRD1 EPAS1

2.21e-065911071115231748
Pubmed

A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.

CUL3 KLHL2 KBTBD2 VPS13D KLHL36

7.58e-0687107537495603
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

TTF2 ZC3H14 ACACA SMC4 HEATR1 NF2 SUB1 ENAH PRRC2B DCAF7

7.91e-065491071038280479
Pubmed

Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism.

DUOX2 DUOX1

9.38e-062107228633507
Pubmed

Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit.

ATP6V1B1 ATP6V1B2

9.38e-062107217392376
Pubmed

Changes in V-ATPase subunits of human urinary exosomes reflect the renal response to acute acid/alkali loading and the defects in distal renal tubular acidosis.

ATP6V1B1 ATP6V1B2

9.38e-062107229310826
Pubmed

Reactive oxygen species regulate the levels of dual oxidase (Duox1-2) in human neuroblastoma cells.

DUOX2 DUOX1

9.38e-062107222523549
Pubmed

Expression of dual oxidases and secreted cytokines in chronic rhinosinusitis.

DUOX2 DUOX1

9.38e-062107223281318
Pubmed

Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors.

EPHB2 GRIN2B

9.38e-062107211799243
Pubmed

Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice.

ATP6V1B1 ATP6V1B2

9.38e-062107217898041
Pubmed

Dual oxidase 1 and NADPH oxidase 2 exert favorable effects in cervical cancer patients by activating immune response.

DUOX2 DUOX1

9.38e-062107231706280
Pubmed

Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.

DUOX2 DUOX1

9.38e-062107215972824
Pubmed

Conserved cysteine residues provide a protein-protein interaction surface in dual oxidase (DUOX) proteins.

DUOX2 DUOX1

9.38e-062107223362256
Pubmed

Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation.

DUOX2 DUOX1

9.38e-062107219144650
Pubmed

Hyaluronate synthase-2 overexpression alters estrogen dependence and induces histone deacetylase inhibitor-like effects on ER-driven genes in MCF7 breast tumor cells.

ESR1 HAS2

9.38e-062107228137613
Pubmed

Expression of nicotinamide adenine dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid carcinomas.

DUOX2 DUOX1

9.38e-062107211762710
Pubmed

Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.

DUOX2 DUOX1

9.38e-062107211822874
Pubmed

FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration.

ARHGAP24 ROCK1

9.38e-062107223097497
Pubmed

Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease.

DUOX2 DUOX1

9.38e-062107218177232
Pubmed

Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense.

DUOX2 DUOX1

9.38e-062107212824283
Pubmed

Congenital Hypothyroidism due to Oligogenic Mutations in Two Sudanese Families.

DUOX2 DUOX1

9.38e-062107230375286
Pubmed

17β-Estradiol sensitizes ovarian surface epithelium to transformation by suppressing Disabled-2 expression.

ESR1 DAB2

9.38e-062107229196616
Pubmed

Presence of serum autoantibodies to vacuolar H+ -ATPase in patients with renal tubular acidosis.

ATP6V1B1 ATP6V1B2

9.38e-062107230821427
Pubmed

Systematic bioinformatic approaches reveal novel gene expression signatures associated with acquired resistance to EGFR targeted therapy in lung cancer.

ESR1 ELAVL1

9.38e-062107229758295
Pubmed

Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.

DUOX2 DUOX1

9.38e-062107210806195
Pubmed

Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.

DUOX2 DUOX1

9.38e-062107211514595
Pubmed

Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling.

DUOX2 DUOX1

9.38e-062107224161126
Pubmed

Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues.

DUOX2 DUOX1

9.38e-062107211443211
Pubmed

Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas.

DUOX2 DUOX1

9.38e-062107210601291
Pubmed

Overexpression of EphB2 in hippocampus rescues impaired NMDA receptors trafficking and cognitive dysfunction in Alzheimer model.

EPHB2 GRIN2B

9.38e-062107228358367
Pubmed

Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension.

CUL3 KLHL2

9.38e-062107226607111
Pubmed

The extracellular A-loop of dual oxidases affects the specificity of reactive oxygen species release.

DUOX2 DUOX1

9.38e-062107225586178
Pubmed

Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.

DUOX2 DUOX1

9.38e-062107216111680
Pubmed

RNA binding protein HuR regulates the expression of ABCA1.

ABCA1 ELAVL1

9.38e-062107224729624
Pubmed

Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases.

DUOX2 DUOX1

9.38e-062107211753072
Pubmed

Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer.

DUOX2 DUOX1

9.38e-062107218281478
Pubmed

Structural and functional characterization of the two human ThOX/Duox genes and their 5'-flanking regions.

DUOX2 DUOX1

9.38e-062107215062544
Pubmed

MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer.

MBD3 EPAS1

9.38e-062107227465550
Pubmed

Regulated hydrogen peroxide production by Duox in human airway epithelial cells.

DUOX2 DUOX1

9.38e-062107215677770
Pubmed

Mucosal reactive oxygen species are required for antiviral response: role of Duox in influenza a virus infection.

DUOX2 DUOX1

9.38e-062107224128054
Pubmed

Heterogeneity of vacuolar H(+)-ATPase: differential expression of two human subunit B isoforms.

ATP6V1B1 ATP6V1B2

9.38e-06210727945239
Pubmed

Mutant γPKC that causes spinocerebellar ataxia type 14 upregulates Hsp70, which protects cells from the mutant's cytotoxicity.

PRKCG HSPA4

9.38e-062107224021284
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

EPHB2 ACACA CCDC32 HEATR1 DNAJB9 MBD3 PREX2 SLC39A8 AZIN1 SERPINB6 NF2 SUB1 ELAVL1 BRD1 OBI1

1.37e-0513271071532694731
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

ZC3H14 ARHGAP24 TRIO SMC4 HEATR1 ECH1 MBD3 PREX2 SUB1 ITSN2 ENAH DCAF7

2.60e-059161071232203420
Pubmed

Repression of transcriptional activity of estrogen receptor alpha by a Cullin3/SPOP ubiquitin E3 ligase complex.

CUL3 ESR1

2.81e-053107218414007
Pubmed

Reciprocal activation of hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis.

SLC39A8 EPAS1

2.81e-053107226241779
Pubmed

pVHL-mediated degradation of HIF-2α regulates estrogen receptor α expression in normoxic breast cancer cells.

ESR1 EPAS1

2.81e-053107227323688
Pubmed

Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis.

CUL3 KLHL2

2.81e-053107221549840
Pubmed

FLI1 Exonic Circular RNAs as a Novel Oncogenic Driver to Promote Tumor Metastasis in Small Cell Lung Cancer.

FLI1 ROCK1

2.81e-053107230429198
Pubmed

Squamous cell carcinoma-related oncogene (SCCRO) neddylates Cul3 protein to selectively promote midbody localization and activity of Cul3KLHL21 protein complex during abscission.

CUL3 DCUN1D1

2.81e-053107228620047
Pubmed

miR-191/DAB2 axis regulates the tumorigenicity of estrogen receptor-positive breast cancer.

ESR1 DAB2

2.81e-053107229247596
Pubmed

NADPH oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomy.

DUOX2 DUOX1

2.81e-053107221915726
Pubmed

FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.

ARHGAP24 ROCK1

2.81e-053107216862148
Pubmed

Tissue specific expression of the splice variants of the mouse vacuolar proton-translocating ATPase a4 subunit.

ATP6V1B1 ATP6V1B2

2.81e-053107217971301
Pubmed

p67 isoform of mouse disabled 2 protein acts as a transcriptional activator during the differentiation of F9 cells.

DAB2 PIAS2

2.81e-053107211104669
Pubmed

NADPH oxidase-dependent acid production in airway epithelial cells.

DUOX2 DUOX1

2.81e-053107215210697
Pubmed

Role of nicotinamide adenine dinucleotide phosphate oxidase in mediating vesicant-induced interleukin-6 secretion in human airway epithelial cells.

DUOX2 DUOX1

2.81e-053107224164541
Pubmed

DUOX enzyme activity promotes AKT signalling in prostate cancer cells.

DUOX2 DUOX1

2.81e-053107223225414
Pubmed

Effect of folate deficiency on promoter methylation and gene expression of Esr1, Cav1, and Elavl1, and its influence on spermatogenesis.

ESR1 ELAVL1

2.81e-053107228445960
Pubmed

Association of duoxes with thyroid peroxidase and its regulation in thyrocytes.

DUOX2 DUOX1

2.81e-053107219952225
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

ZC3H14 CT45A6 CT45A1 OXR1 CT45A10 CT45A2 PIAS2 ATP8B2 CT45A7 ARSG CT45A9 APPL2 CT45A3 PRRC2B

2.81e-0512421071430973865
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

CUL3 FLI1 TTF2 ZC3H14 SMC4 MSH2 PPWD1 MBD3 SUB1 ELAVL1 HSPA4 PRRC2B DCAF7

3.52e-0511031071334189442
Pubmed

Identification of Modifier Genes in a Mouse Model of Gaucher Disease.

ATP6V1B2 GRIN2B NF2

4.18e-0522107327568557
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CUL3 ARHGAP24 TRIO GRIN2B MBD3 TMEM259 ENAH ELAVL1 ROCK1 PRKCG PRRC2B DCAF7

4.22e-059631071228671696
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

CT45A6 CT45A1 ABCA1 CT45A10 CT45A2 PREX2 CT45A7 CT45A9 CT45A3 MYPN

4.55e-056741071037196079
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

ACACA TRIO DAB2 CEP350 VPS13D MYPN

4.78e-05209107636779422
Pubmed

H+-ATPase B1 subunit localizes to thick ascending limb and distal convoluted tubule of rodent and human kidney.

ATP6V1B1 ATP6V1B2

5.60e-054107229993276
Pubmed

Ubiquitination and downregulation of ErbB2 and estrogen receptor-alpha by kinase inhibitor MP-412 in human breast cancer cells.

ESR1 HSPA4

5.60e-054107221503962
Pubmed

Soluble bovine galactose-binding lectin. cDNA cloning reveals the complete amino acid sequence and an antigenic relationship with the major encephalitogenic domain of myelin basic protein.

ATP8B2 MBD3

5.60e-05410722470348
Pubmed

The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA.

DUOX2 DUOX1

5.60e-054107222814254
Pubmed

Hippocampal Lnx1-NMDAR multiprotein complex mediates initial social memory.

EPHB2 GRIN2B

5.60e-054107231772302
Pubmed

Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF.

DUOX2 DUOX1

5.60e-054107227110716
Pubmed

FLI-1 functionally interacts with PIASxalpha, a member of the PIAS E3 SUMO ligase family.

FLI1 PIAS2

5.60e-054107216148010
Pubmed

The Role of Cysteine String Protein α Phosphorylation at Serine 10 and 34 by Protein Kinase Cγ for Presynaptic Maintenance.

PRKCG HSPA4

5.60e-054107229167402
Pubmed

hMutS alpha is protected from ubiquitin-proteasome-dependent degradation by atypical protein kinase C zeta phosphorylation.

MSH2 PRKCG

5.60e-054107215808853
Pubmed

SCCRO (DCUN1D1) promotes nuclear translocation and assembly of the neddylation E3 complex.

CUL3 DCUN1D1

5.60e-054107221247897
Pubmed

Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.

DUOX2 DUOX1

5.60e-054107219339556
Pubmed

V-ATPase expression in the mouse olfactory epithelium.

ATP6V1B1 ATP6V1B2

5.60e-054107218667600
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

CUL3 TTF2 ACACA TRIO KBTBD2 ECH1 CEP350 ITSN2 ENAH GARRE1 PRRC2B

6.61e-058531071128718761
Pubmed

Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.

DUOX2 LRRK1 DUOX1

6.99e-0526107333905568
Pubmed

Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation.

ATP6V1B1 ATP6V1B2 OXR1

7.85e-0527107326442671
Pubmed

A germline-specific class of small RNAs binds mammalian Piwi proteins.

HIRIP3 GPR63 HEATR1 ATP8B2 NF2 ITSN2 PRRC2B DCAF7

7.87e-05450107816751776
Pubmed

RhoBTB1 interacts with ROCKs and inhibits invasion.

CUL3 ROCK1

9.32e-055107231431478
Pubmed

Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation.

ROCK1 PRKCG

9.32e-055107221685893
Pubmed

Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy.

ATP6V1B1 ATP6V1B2

9.32e-055107227384406
Pubmed

Protease-activated receptor 1 inhibits cholesterol efflux and promotes atherogenesis via cullin 3-mediated degradation of the ABCA1 transporter.

CUL3 ABCA1

9.32e-055107229777060
Pubmed

Expression of TPO and ThOXs in human thyrocytes is downregulated by IL-1alpha/IFN-gamma, an effect partially mediated by nitric oxide.

DUOX2 DUOX1

9.32e-055107216478776
Pubmed

Distinct profile of HIF1α, PTCH, EphB2, or DNA repair protein expression and BRAF mutation in colorectal serrated adenoma.

EPHB2 MSH2

9.32e-055107224612059
Pubmed

The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer.

DAB2 PRKCG

9.32e-055107210542228
Pubmed

The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor alpha.

ESR1 MSH2

9.32e-055107215886699
Pubmed

Identification of a novel partner of duox: EFP1, a thioredoxin-related protein.

DUOX2 DUOX1

9.32e-055107215561711
Pubmed

Inhibitory actions of genistein in human breast cancer (MCF-7) cells.

ESR1 DAB2

9.32e-055107212853125
Pubmed

Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation.

DUOX2 DUOX1

9.32e-055107234784249
Pubmed

The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.

RFPL4AL1 RFPL4A

9.32e-055107211850190
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

TTF2 TRIO DAB2 MSH2 HEATR1 SRBD1 NF2 SLC4A1AP

1.09e-04472107838943005
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

FLI1 HIRIP3 MSH2 SRBD1 PIAS2 MBD3 SLC4A1AP SUB1 BRD1

1.13e-04608107936089195
Pubmed

Association of polymorphisms in genes involved in lipoprotein metabolism with plasma concentrations of remnant lipoproteins and HDL subpopulations before and after hormone therapy in postmenopausal women.

ABCA1 ESR1

1.40e-046107219489872
Pubmed

Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult.

DUOX2 DUOX1

1.40e-046107217332529
Pubmed

APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury.

DUOX2 DUOX1

1.40e-046107228165467
InteractionCSNK2A1 interactions

CUL3 BDP1 CT45A1 ABCA1 ACACA HIRIP3 ESR1 GRIN2B SRBD1 MBD3 BIK SLC4A1AP CT45A3 SUB1 CT45A5 ELAVL1 HSPA4 DCAF7

9.75e-0795610018int:CSNK2A1
InteractionGPBP1L1 interactions

ESR1 LRRK1 CT45A5 ELAVL1 GARRE1 DCAF7

4.38e-06861006int:GPBP1L1
InteractionRAB22A interactions

ATP6V1B1 ESR1 APPL2 ELAVL1

4.70e-06231004int:RAB22A
InteractionSIRT1 interactions

CUL3 ACACA ESR1 MBD3 CT45A5 ELAVL1 BRD1 HSPA4 OBI1 EPAS1 PRRC2B

6.33e-0641210011int:SIRT1
InteractionCT45A10 interactions

CT45A1 CT45A10 ESR1

6.52e-0681003int:CT45A10
InteractionSDCBP interactions

EPHB2 KLHL2 CT45A1 CT45A10 ESR1 MBD3 NF2 CT45A3 SUB1 CT45A5 ELAVL1

1.17e-0544010011int:SDCBP
InteractionLIN7C interactions

EPHB2 ABCA1 ESR1 GRIN2B NF2 ELAVL1

2.83e-051191006int:LIN7C
InteractionSEC23A interactions

EPHB2 CUL3 ARHGAP24 HIRIP3 MSH2 PIAS2 DCUN1D1 HSPA4

4.02e-052551008int:SEC23A
InteractionZNF91 interactions

CUL3 ARHGAP24 ELAVL1

4.15e-05141003int:ZNF91
InteractionPPP6R3 interactions

CUL3 ESR1 SMC4 ECH1 FMNL2 MBD3 ENAH ELAVL1

4.36e-052581008int:PPP6R3
InteractionACBD3 interactions

EPHB2 CUL3 ACACA RHBDF2 SMC4 SLC4A1AP ELAVL1 HSPA4

4.48e-052591008int:ACBD3
InteractionROCK1 interactions

EPHB2 CUL3 ARHGAP24 PHKA2 ITSN2 ROCK1 DCAF7

4.84e-051921007int:ROCK1
InteractionKPNA1 interactions

CUL3 ESR1 SRBD1 MBD3 SUB1 ELAVL1 BRD1 HSPA4 EPAS1

6.29e-053511009int:KPNA1
InteractionNET1 interactions

ESR1 HEATR1 ELAVL1 DCAF7

6.65e-05441004int:NET1
InteractionPSMD1 interactions

CUL3 BDP1 ARHGAP24 ACACA ESR1 SMC4 PPWD1 MBD3 SLC4A1AP EPAS1

6.93e-0544210010int:PSMD1
InteractionCNOT7 interactions

ESR1 ELAVL1 OBI1 GARRE1 EPAS1 PRRC2B

7.04e-051401006int:CNOT7
InteractionDPY30 interactions

CUL3 ARHGAP24 ESR1 MBD3 BRD1 EPAS1 PRRC2B

7.10e-052041007int:DPY30
InteractionZNF714 interactions

CUL3 ARHGAP24 ELAVL1

9.16e-05181003int:ZNF714
InteractionGSK3A interactions

ZC3H14 ACACA TRIO DAB2 SRBD1 ARSG CEP350 VPS13D MYPN PRKCG

1.03e-0446410010int:GSK3A
InteractionPRKAR2A interactions

CUL3 ACACA ESR1 SMC4 SLC4A1AP ELAVL1 HSPA4

1.04e-042171007int:PRKAR2A
CytobandEnsembl 112 genes in cytogenetic band chrXq26

CT45A6 CT45A1 CT45A10 CT45A2 CT45A7 CT45A9 CT45A8 CT45A3 CT45A5

2.93e-101711079chrXq26
CytobandXq26.3

CT45A6 CT45A1 CT45A2 CT45A3 CT45A5

5.39e-07671075Xq26.3
GeneFamilyGlycosyl transferases group 1 domain containing

GLT1D1 GTDC1

5.28e-0410632427
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_MYOFIBROBLAST_1_CELL

CT45A6 CT45A1 CT45A10 CT45A2 CT45A7 CT45A9 CT45A8 CT45A3 CT45A5

8.69e-12691059M45681
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_MYOFIBROBLAST_2_CELL

CT45A6 CT45A1 CT45A10 CT45A2 CT45A7 CT45A9 CT45A8 CT45A3 CT45A5

3.75e-101041059M45682
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

BDP1 SMC4 ADGRG1 MSH2 PPWD1 CEP350 DCUN1D1 SLC4A1AP ITSN2 ENAH HAS2 OBI1

1.28e-0565610512M18979
CoexpressionSENESE_HDAC3_TARGETS_UP

BDP1 TCN1 TRIO HEATR1 KBTBD2 GTDC1 FMNL2 TMEM259 HAS2 HSPA4

3.06e-0549510510M8451
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CT45A6 CT45A1 CT45A10 CT45A2 CT45A9 CT45A5 ENAH

1.00e-071571067b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CT45A6 CT45A1 CT45A10 CT45A2 CT45A9 CT45A5 ENAH

3.67e-071901067d24af6af3271e34afab744352afd28be8a7cc5c3
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CT45A6 CT45A1 CT45A10 CT45A2 CT45A9 CT45A5

3.32e-061701066fefb07a7e308b620f946b9ff2b01e1796446fe38
ToppCellfacs-SCAT|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA1 TRIO ESR1 HACD4 DUOX1 HAS2

4.62e-0618010666c70b6b7480507fa94625013222ad338ee7dd1d9
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_1|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CT45A6 CT45A1 CT45A10 CT45A2 CT45A9 CT45A5

6.30e-06190106671a00f63fdd4eb4cc6f190d37e7a0417cdaafacb
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CT45A6 CT45A1 CT45A10 CT45A2 CT45A9 CT45A5

6.89e-0619310662f203f6f0c2135acb046c9351a633c3b5b254a46
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

SMC4 ADGRG1 GALNT7 CEP350 VPS13D ROCK1

7.97e-06198106676d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_1|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CT45A6 CT45A1 CT45A10 CT45A2 CT45A9

4.05e-0516010655cd4fbbd2ce671a8377416eff94041a111375dee
ToppCellmetastatic_Lymph_Node-Myeloid_cells-CD141+_DCs|Myeloid_cells / Location, Cell class and cell subclass

PREX2 RFPL4AL1 BIK RFPL4A SUB1

5.26e-051691065a4204bdd75837f5fee9aaac459cb4c19ee2a7bf4
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic-CD1c-positive_myeloid_dendritic_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ATP6V1B2 ABCA1 RHBDF2 TRIO FMNL2

5.41e-051701065cc66ac6846c58be9493eb270644ee3ce0f86cfea
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l19|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

7.47e-051821065840427d1c23d60482c943ff006b14007ed44d247
ToppCelldroplet-Pancreas-Exocrine-18m-Endothelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 GLB1L3 DAB2 PREX2 EPAS1

7.47e-0518210653b4dbf61ca0fe50efe05449815630e301cb76630
ToppCelldroplet-Pancreas-Exocrine-18m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 GLB1L3 DAB2 PREX2 EPAS1

7.47e-051821065ab5761bf9af439231cd0f487b6467e372672a517
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TCN1 GLT1D1 HEATR1 SLC39A8 SERPINB10

7.86e-051841065a8c6028d745aaa6ee7842259238694cb50ce0526
ToppCelldroplet-Trachea-nan-3m-Endothelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

7.86e-051841065fa5c3020e75fdde1363393dea97ebd99f1eae9ff
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TCN1 GLT1D1 HEATR1 SLC39A8 SERPINB10

7.86e-051841065081d045f3bc98a36f342de7d50f39c9a888dd7eb
ToppCellControl-Myeloid_G-immature_Neutrophil|Control / Disease group, lineage and cell class

TCN1 GLT1D1 HEATR1 SLC39A8 SERPINB10

7.86e-05184106545f873236f7e90fb78c8e291d3b5b92d121acec9
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

TCN1 GLT1D1 HEATR1 SLC39A8 SERPINB10

7.86e-05184106584c20730cd92b9aaa50077d7b625e37e7f9e91d2
ToppCelldroplet-Trachea-3m-Endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

7.86e-051841065ad520ab6bb776b5303df505b7e1afb22484f18a7
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TCN1 GLT1D1 HEATR1 SLC39A8 SERPINB10

7.86e-051841065d31d4116d1d196633784863781fa45673607a421
ToppCelldroplet-Trachea-nan-3m-Endothelial-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

7.86e-0518410651d63cb75a89c5f3f3b9ebf7fce8cb0fd4a92b645
ToppCelldroplet-Trachea-nan-3m-Endothelial-endothelial_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

7.86e-05184106576caad53d55fff5acca27bf190a6de7b27437d9f
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

7.86e-0518410651fc1f0a3b4dbb085ebcc3960f67be24a108fe5b9
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

7.86e-0518410652467207aaea307873ab286f89cfc7668a227a694
ToppCellfacs-Aorta-Heart-3m-Endothelial-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

8.48e-051871065df0279b7e94e26f5541b0e2a0ce56befa96ec8ca
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

8.70e-05188106520072a2a3f9ecbe727c850629f19420cf60e4bc5
ToppCellfacs-Trachea-3m-Endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

8.70e-051881065dd817059e1b4225e84733559f7839cc973b7dfd6
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

8.70e-0518810656ab5ce8569f896a0fe7a76b8b4a83661e5499b8c
ToppCellfacs-Trachea-nan-3m-Endothelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

8.92e-051891065f60ac60ab9b317a0196f0cbbe520ef7dbd19ac11
ToppCellfacs-Trachea-nan-3m-Endothelial-endothelial_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

8.92e-051891065e3d65417997bdd3f9c312c0977dceb6eca061029
ToppCellfacs-Trachea-nan-3m-Endothelial-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

8.92e-0518910655559af03d9d612bb8dcf825e45744a9f8332bac8
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CUL3 HEATR1 LRRK1 PPWD1 BRD1

9.14e-05190106591ba66d4b56c59523485b17738e93f14bb00afa4
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

9.14e-05190106538a815abf0ac5cac6071737cadc54a514f62d37d
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

9.14e-051901065bb1476b44dd49e1dd52a636a91c4600b6d4fbe2e
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

9.14e-051901065d180205c70b5ca9bc5a01a2e6cb42fcebc7f630d
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

9.14e-0519010652655df8c0883dd811fa7617301f9c4b0a4dd55ec
ToppCellfacs-Heart-LA-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

9.37e-051911065a15f0fb4bd7dd77ef5f931b6fc9d68697deec1d1
ToppCellfacs-Heart-LA-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

9.37e-051911065827be47d3574c6c5b021c6f1c1670834344f10cb
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Endothelial-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

9.60e-0519210658f20d3511dcb44445592b17d005a53da0052ae56
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Endothelial-endothelial_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

9.60e-0519210650986b7900021efe2a4df84a935e7c9a0af1b0e57
ToppCell(1)_Control_(PBS)-(1)_VE-Cad+_vascular_cells|(1)_Control_(PBS) / Stress and Cell class

FLI1 DAB2 ADGRG1 PREX2 SLC39A8

9.60e-051921065e16e49b302019474232ef4cc0ff217d33afe34cf
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Endothelial|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

9.60e-051921065b28d294e42b303d1db6060231d84d7b9e4d9fccf
ToppCell(4)_Endothelial_cells|World / Cell class and subclass of bone marrow stroma cells in homeostatis

FLI1 ADGRG1 PREX2 BIK EPAS1

9.84e-051931065ae6ba13d4d9f2a700887cdda2790c32007b29ac8
ToppCellRV-09._Endothelium_I|World / Chamber and Cluster_Paper

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

9.84e-051931065e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V1B2 ABCA1 GLT1D1 SLC39A8 DDX60L

1.01e-0419410653ef9e88e66f2f2ae95dcc834ea605c40c60783fc
ToppCelldroplet-Fat-Scat-18m-Endothelial-Cd36+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

1.01e-041941065009b005a94a5c80f6e1fdda2a0c7881a9a0ce75b
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

1.03e-04195106598d79f6a8a5cc86a219efe8db9f9535d7ad4c5be
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

1.03e-041951065ea0627ffe1750dbdd48006d251c0ba4cadd32faf
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

1.03e-0419510653b95a989adb99591b44704ff4c496a1c6cb0bb18
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)|Adult / Lineage, Cell type, age group and donor

ATP6V1B2 ABCA1 GTDC1 FMNL2 DDX60L

1.03e-04195106555e25f702af19146a161861cfd15f40bbda1dc35
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAB2 ADGRG1 PREX2 SLC39A8 GARRE1

1.06e-04196106581900dcc9451ff6606ec940c16b559d73247590e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLI1 PREX2 SERPINB6 GARRE1 EPAS1

1.06e-041961065145fcf73deba9638b391a1af6c39fa205dc9829f
ToppCellmild_COVID-19_(asymptomatic)|World / disease group, cell group and cell class (v2)

EPHB2 HGD ABCA1 DAB2 DDX60L

1.06e-0419610658cb3dcb3e5732f4bb060c87ca339b8997a1a8cd4
ToppCellControl_saline-Endothelial-Endothelial-Activated_Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

FLI1 GRIN2B KBTBD2 RTL9 GARRE1

1.11e-0419810653c3a5d2555f6af4aa33f9ea778808315d0e39d86
ToppCellLPS_only|World / Treatment groups by lineage, cell group, cell type

ABCA1 RHBDF2 SLC39A8 AZIN1 HAS2

1.14e-041991065852cf595c2255983cff9045f2bb746d4391cf5ba
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

ATP6V1B1 GALNT7 CEP350 ITSN2 ROCK1

1.14e-041991065c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FLI1 TRIO PREX2 GARRE1 EPAS1

1.16e-042001065dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FLI1 ADGRG1 KBTBD2 PREX2 EPAS1

1.16e-0420010652d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCellControl-Control-Myeloid-immature_Neutrophil|Control / Disease, condition lineage and cell class

TCN1 GLT1D1 HEATR1 SLC39A8 SERPINB10

1.16e-042001065118321ac443feb42aee171baccfc4610f00a8822
ToppCellLPS_only-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

1.16e-04200106581e76508c9050d533853d5fd2f3097b27613d836
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Artery|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ADGRG1 PREX2 SERPINB6 GARRE1 EPAS1

1.16e-04200106577ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BDP1 CEP350 ITSN2 ROCK1 DDX60L

1.16e-04200106512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellControl_saline-Endothelial-Endothelial-Artery|Control_saline / Treatment groups by lineage, cell group, cell type

PREX2 AZIN1 ITSN2 GARRE1 EPAS1

1.16e-04200106565b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / Treatment groups by lineage, cell group, cell type

ADGRG1 PREX2 SERPINB6 GARRE1 EPAS1

1.16e-042001065b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

FLI1 ADGRG1 PREX2 GARRE1 EPAS1

1.16e-0420010654bb609a284d4e6066f17470a1736076aa4a1f84c
ComputationalGenes in the cancer module 243.

BDP1 CCDC32 ECH1 WDR19 DCUN1D1 APPL2 SUB1

5.77e-0781667MODULE_243
ComputationalNeighborhood of CDC2L5

ATP6V1B1 ESR1 PIAS2 CEP350 ROCK1 BRD1

2.26e-04142666MORF_CDC2L5
DrugIopamidol [60166-93-0]; Down 200; 5.2uM; PC3; HT_HG-U133A

EPHB2 TRIO ATP8B2 BIK CEP350 VPS13D NF2 KLHL36 PRRC2B

2.59e-0719910195832_DN
Drugretinoic acid; Up 200; 1uM; PC3; HT_HG-U133A

EPHB2 ABCA1 LRRK1 DNAJB9 VPS13D NF2 TMEM259 HAS2

2.20e-0619110181211_UP
DrugTiletamine hydrochloride; Down 200; 15.4uM; MCF7; HT_HG-U133A

RHBDF2 ESR1 SMC4 ADGRG1 DNAJB9 ATP8B2 TMEM259 GARRE1

2.29e-0619210186013_DN
DrugTriamterene [396-01-0]; Down 200; 15.8uM; HL60; HT_HG-U133A

CUL3 FLI1 GPR63 MBD3 VPS13D TMEM259 ITSN2 PRRC2B

2.67e-0619610181861_DN
Drug15(S)-15-methyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A

ATP6V1B1 ESR1 ADGRG1 LRRK1 DUOX1 TMEM259 HAS2

2.40e-0519210177489_UP
DrugChlorpromazine hydrochloride [69-09-0]; Up 200; 11.2uM; HL60; HT_HG-U133A

EPHB2 ABCA1 ACACA TCN1 DNAJB9 ATP8B2 KLHL36

2.48e-0519310171864_UP
DrugSulfamerazine [127-79-7]; Down 200; 15.2uM; MCF7; HT_HG-U133A

ESR1 SMC4 DNAJB9 ATP8B2 PREX2 VPS13D NF2

2.65e-0519510174740_DN
DrugLactobionic acid [96-82-2]; Down 200; 11.2uM; PC3; HT_HG-U133A

EPHB2 FLI1 DNAJB9 ATP8B2 CEP350 VPS13D TMEM259

2.73e-0519610176605_DN
DrugSTOCK1N-35696; Up 200; 15uM; PC3; HT_HG-U133A

TRIO SMC4 MBD3 KLHL36 BRD1 HSPA4 DCAF7

2.82e-0519710176564_UP
DrugBenzonatate [104-31-4]; Up 200; 6.6uM; HL60; HT_HG-U133A

TCN1 ATP8B2 MBD3 APPL2 NF2 GARRE1 DCAF7

2.82e-0519710171843_UP
DrugLevamisole hydrochloride [16595-80-5]; Down 200; 16.6uM; PC3; HT_HG-U133A

EPHB2 TCN1 ATP8B2 CEP350 VPS13D VPS35L BRD1

2.92e-0519810172094_DN
DrugFuraltadone hydrochloride [3759-92-0]; Down 200; 11uM; PC3; HT_HG-U133A

EPHB2 CUL3 FLI1 ARHGAP24 TRIO DNAJB9 NF2

3.01e-0519910174313_DN
Diseasephenylketonuria (implicated_via_orthology)

DUOX2 DUOX1

6.00e-054942DOID:9281 (implicated_via_orthology)
Diseaseblood platelet disease (is_implicated_in)

EPHB2 FLI1

9.98e-055942DOID:2218 (is_implicated_in)
Diseasefollicular lymphoma (implicated_via_orthology)

ATP6V1B1 ATP6V1B2

9.98e-055942DOID:0050873 (implicated_via_orthology)
Diseasehippocampus volume change measurement, age at assessment

LRRK1 DNAJB9 BIK

1.08e-0429943EFO_0008007, EFO_0021492
Diseaserenal tubular acidosis (implicated_via_orthology)

ATP6V1B1 ATP6V1B2

2.78e-048942DOID:14219 (implicated_via_orthology)
Diseaseprimary bacterial infectious disease (implicated_via_orthology)

DUOX2 DUOX1

3.56e-049942DOID:0050338 (implicated_via_orthology)
Diseasefetal genotype effect measurement, body weights and measures

ESR1 HSPA4 EPAS1

5.19e-0449943EFO_0004324, EFO_0007959
Diseasetotal blood protein measurement

FLI1 ESR1 DAB2 LRRK1 SLC39A8 BIK ROCK1

5.91e-04449947EFO_0004536
Diseasehypothyroidism (implicated_via_orthology)

DUOX2 DUOX1

7.65e-0413942DOID:1459 (implicated_via_orthology)
Diseasecongenital hypothyroidism (implicated_via_orthology)

DUOX2 DUOX1

8.91e-0414942DOID:0050328 (implicated_via_orthology)
Diseaseserum non-albumin protein measurement

FLI1 DAB2 LRRK1 SLC39A8 BIK NF2

1.06e-03361946EFO_0004568
Diseaseerythrocyte cadmium measurement

ATP6V1B2 SLC39A8

1.32e-0317942EFO_0007807
Diseaseamino acid measurement

EPHB2 GLB1L3 LRRK1 GRIN2B GTDC1 UNC13C HAS2 EPAS1

1.47e-03678948EFO_0005134
DiseaseUterine leiomyoma, estrogen-receptor positive breast cancer

ESR1 HSPA4

1.49e-0318942EFO_1000649, HP_0000131
Diseaseglaucoma

ABCA1 SRBD1 FMNL2 WDR19

1.51e-03154944MONDO_0005041
Diseaseepilepsy (biomarker_via_orthology)

GRIN2B NF2

2.03e-0321942DOID:1826 (biomarker_via_orthology)
Diseasevisual epilepsy (biomarker_via_orthology)

MSH2 MBD3 BRD1

3.01e-0390943DOID:11832 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
KMDSEEKQFSTMRSG

ADAM29

151

Q9UKF5
EKQFSTMRSGFMQNE

ADAM29

156

Q9UKF5
GDMIFLSENISKFMG

EPAS1

106

Q99814
DQMLMEAFFKVERGS

EPG5

2066

Q9HCE0
VSQSMFEFLMDRFEK

BRD1

181

O95696
KETDMFFLAISMVGT

BDP1

306

A6H8Y1
QDAGITSDSMMKNFF

AZIN1

416

O14977
EDGFNLTTSVSMMLF

ABCA1

816

O95477
SQIDDFTGFSKDGMM

CT45A5

71

P0DMU8
QRMGGMVSFRTFEDF

ACACA

1231

Q13085
KMASEGMRFVDFHAA

ARSG

66

Q96EG1
SFMDGFTTLKENIMR

BIK

106

Q13323
EDMEKMFSFSGFDST

DNAJB9

171

Q9UBS3
SQIDDFTGFSKDGMM

CT45A7

71

P0DMV0
EFSKQEFMDGMTELG

DCUN1D1

116

Q96GG9
MFASVGADGSVRMFD

DCAF7

191

P61962
DFQDMIGEDKNSFFM

CCNB3

551

Q8WWL7
REKMMDSSRSVGNGF

ATP8B2

736

P98198
QKRMAESGFLTEGEM

ITSN2

1236

Q9NZM3
QDMFVESMFSLADKD

DUOX1

816

Q9NRD9
LKSGVDQMDLFGDMS

DAB2

206

P98082
FNSMFTIGMREAFQK

KLHL36

71

Q8N4N3
MAREKEMQEFTRSFF

HIRIP3

1

Q9BW71
FMNDVDVSGTMNRGK

HSPA4

291

P34932
SMDLSTFDFRTGKML

MBD3

56

O95983
TNMTVRFFSFGKDSM

HACD4

36

Q5VWC8
DAMKNFSEFRQEASM

LRRK1

1296

Q38SD2
SQIDDFTGFSKDGMM

CT45A10

71

P0DMU9
SLEMKMSFFERLRSA

GLB1L3

546

Q8NCI6
MGSKDHAVFFREMTQ

DDX60L

1

Q5H9U9
DMFVESMFSLADKDG

DUOX2

821

Q9NRD8
ENGFLSKDEFFTMMR

DUOX2

871

Q9NRD8
MIITEFMENGSLDSF

EPHB2

696

P29323
SMKFRTDMAFVRGSS

GPATCH3

501

Q96I76
TSSRFRMMNLQGEEF

ESR1

431

P03372
MDKNQTEVMREFFLS

OR4Q2

1

P0C623
SQIDDFTGFSKDRMM

CT45A3

71

Q8NHU0
AFTARKMMADEALGS

ECH1

226

Q13011
QRFGSSLFKMSSEMH

OBI1

666

Q5W0B1
FRAMFMSGLSESKQT

KBTBD2

56

Q8IY47
SRNDFMGAMSFGVSE

PRKCG

251

P05129
FDEMVNMGKFILTFS

LRGUK

471

Q96M69
TMTQKDVEDMFSRFG

ELAVL1

116

Q15717
MRKFQVDMTFDVDTA

RFPL4A

91

A6NLU0
GSTESMLFAVMAFDL

OR12D2

106

P58182
SFDFKDTDMKRLSME

NF2

506

P35240
GDNMFFIKGDMDSLA

OXR1

811

Q8N573
MEKALSMFSDDFGSF

HSPB7

41

Q9UBY9
DMLQKEMEQFFSTFG

ARHGAP24

716

Q8N264
SQIDDFTGFSKDRMM

CT45A1

71

Q5HYN5
SQIDDFTGFSKDRMM

CT45A9

71

P0DMV2
EARFAVAFTESMKEM

GLT1D1

106

Q96MS3
KEFGFNMVASDMISL

GALNT7

171

Q86SF2
EMSAEFFQMESQKFL

CUL3

211

Q13618
FTSKLEGMFRDMSIS

CUL3

466

Q13618
SQIDDFTGFSKDRMM

CT45A2

71

Q5DJT8
KMLMELSAGAANFTD

GARRE1

141

O15063
LMEIDTSFFQNMDGK

FLI1

151

Q01543
MDIFSEVMGRDKSAT

HAS2

131

Q92819
GGQDSFSKFTMEMVR

CEP350

1671

Q5VT06
LTSVRFMGDMVSFEE

ADGRG1

216

Q9Y653
EMFSKRMDSFLSSVA

APPL2

216

Q8NEU8
NLSDEDRFMMQFSKI

FMNL2

761

Q96PY5
EELTMEMFGNSSIKF

TMEM259

156

Q4ZIN3
MKMFESADSTATRSG

CCDC32

1

Q9BV29
SQIDDFTGFSKDRMM

CT45A8

71

P0DMV1
QMSIDMGFKTRAFTT

GPR63

301

Q9BZJ6
IFTFMGANVMRLDDT

HEATR1

1326

Q9H583
FGSKEDANVFASAMM

ENAH

91

Q8N8S7
SRHKTMNFMSLEGTD

CCDC168

6461

Q8NDH2
SEKNQMDTFADFDTM

FAM135B

1176

Q49AJ0
SVFNMESFLTSMGKF

GTDC1

126

Q4AE62
DGKMMTIRTESSFQD

FABP9

46

Q0Z7S8
DFSKFQEMIETTLDM

MSH2

446

P43246
SQIDDFTGFSKDGMM

CT45A6

71

P0DMU7
EMKQMTRRFSADEQF

PHKA2

1006

P46019
MADFEELRNMVSSFR

PIAS2

1

O75928
IADGTMAFMFESSLS

HGD

391

Q93099
SFGNMMSKEKRDSIS

PANK1

496

Q8TE04
MKGFLDDSERMAFLV

RTL9

1176

Q8NET4
FAAMGVNMETARFFK

ATP6V1B2

231

P21281
AAMGVNMETARFFKS

ATP6V1B1

226

P15313
MRKFQVDMTFDVDTA

RFPL4AL1

91

F8VTS6
TGKLMRVFDESLSMF

PPWD1

311

Q96BP3
MTDAFELGKADFSGM

SERPINB6

291

P35237
SSSRDDNMFQIGKMR

SUB1

56

P53999
FFLMKMDDRTSAAES

WDR19

186

Q8NEZ3
RVEDMMKRSFSEFPS

SKIV2L

761

Q15477
SDAEKESVMMFGRNL

SRBD1

511

Q8N5C6
DSGLTTFFKMVSMRD

ULBP3

176

Q9BZM4
RAEFIATRSMDFIGM

VPS35L

436

Q7Z3J2
MFESMGGKELDSEAS

UNC13C

1811

Q8NB66
QKMNDTIFGFTMEER

TCN1

366

P20061
MSGEKEEASLRMFGA

TLE7

1

A0A1W2PR48
SMGSMFRQQSIEDKE

PRRC2B

471

Q5JSZ5
MGFSKSVNEARSKMD

SMC4

486

Q9NTJ3
FRFFSDEEMEGSNMK

PREX2

561

Q70Z35
MSTGDSFETRFEKMD

ROCK1

1

Q13464
EFASRQKSFMETAMD

UBR3

1196

Q6ZT12
RKTDFTFFMIQNAGM

SLC39A8

426

Q9C0K1
SSFFSKEEMSSMPDD

RHBDF2

291

Q6PJF5
FFRNNSEKMSMEDEN

ZC3H14

276

Q6PJT7
MSDAFSQSKADFSGM

SERPINB10

311

P48595
SRSSMEMEGIFNHKD

TRIO

1721

O75962
ADGHVTFTERSMMDK

TANGO2

246

Q6ICL3
GTFFKMELFEGMRES

TTF2

976

Q9UNY4
SMDELEENFRGMLKS

VPS13D

1306

Q5THJ4
FHAMFTGEMSESRAK

KLHL2

81

O95198
LDAFMSEMKSGSTLD

SLC4A1AP

536

Q9BWU0
GLDIFSAFSSMESTM

MYPN

1291

Q86TC9
SMIMADKDESSMFFQ

GRIN2B

131

Q13224