Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription coregulator activity

CBFA2T2 SMARCC2 WWTR1 MED13L BCL9 SRCAP ARID1A MAML3 TP53BP1

2.81e-05562579GO:0003712
GeneOntologyMolecularFunctiontranscription coactivator activity

SMARCC2 WWTR1 BCL9 SRCAP ARID1A MAML3

2.20e-04303576GO:0003713
GeneOntologyMolecularFunctionchromatin binding

DDX12P ANKRD17 SMARCC2 ISL1 MLLT10 MBD5 ARID1A MEF2C PRDM1

2.27e-04739579GO:0003682
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

AP2B1 CBFA2T2 DAB2 SMARCC2 WWTR1 MED13L BCL9 SRCAP ARID1A MAML3 TP53BP1

3.79e-0411605711GO:0030674
GeneOntologyCellularComponentbBAF complex

SMARCC2 ARID1A

3.36e-0410582GO:0140092
GeneOntologyCellularComponentnpBAF complex

SMARCC2 ARID1A

6.74e-0414582GO:0071564
GeneOntologyCellularComponentbrahma complex

SMARCC2 ARID1A

6.74e-0414582GO:0035060
GeneOntologyCellularComponentnBAF complex

SMARCC2 ARID1A

8.86e-0416582GO:0071565
HumanPhenoAbnormality of the hairline

HSPG2 TRIO ANKRD17 SMARCC2 MED13L SRCAP MBD5 ARID1A

7.67e-06294208HP:0009553
HumanPhenoCongenital abnormal hair pattern

HSPG2 TRIO ANKRD17 SMARCC2 MED13L SRCAP MBD5 ARID1A

1.69e-05327208HP:0011361
HumanPhenoAutistic behavior

HSPG2 SLITRK2 TRIO ANKRD17 SMARCC2 MED13L SRCAP MBD5 ARID1A MEF2C

8.58e-056782010HP:0000729
HumanPhenoAbnormal eating behavior

HSPG2 SMARCC2 MBD5 ARID1A ITPR3

1.06e-04128205HP:0100738
HumanPhenoLong eyelashes

HSPG2 SMARCC2 SRCAP MBD5 ARID1A

1.10e-04129205HP:0000527
HumanPhenoHyperactivity

HSPG2 SLITRK2 TRIO ANKRD17 SMARCC2 MED13L SRCAP MBD5 ARID1A

1.18e-04558209HP:0000752
HumanPhenoAbnormality of the frontal hairline

HSPG2 TRIO ANKRD17 SMARCC2 MED13L ARID1A

1.24e-04215206HP:0000599
HumanPhenoHirsutism

HSPG2 TRIO SMARCC2 SRCAP MBD5 ARID1A

1.28e-04216206HP:0001007
HumanPhenoAbnormality of the scalp hair

HSPG2 TRIO ANKRD17 SMARCC2 MED13L SRCAP MBD5 ARID1A

1.29e-04433208HP:0100037
HumanPhenoMacrostomia

TRIO SMARCC2 MED13L SRCAP MBD5 ARID1A

1.41e-04220206HP:0000181
HumanPhenoWide mouth

TRIO SMARCC2 MED13L SRCAP MBD5 ARID1A

1.41e-04220206HP:0000154
HumanPhenoClinodactyly

HSPG2 TRIO SMARCC2 MECOM MED13L SRCAP MBD5 ARID1A MEF2C

1.47e-04574209HP:0030084
HumanPhenoAbnormal scalp morphology

HSPG2 TRIO ANKRD17 SMARCC2 MED13L SRCAP MBD5 ARID1A

1.69e-04450208HP:0001965
HumanPhenoThin upper lip vermilion

TRIO ANKRD17 SMARCC2 SRCAP MBD5 ARID1A MEF2C

1.98e-04339207HP:0000219
HumanPhenoThin lips

TRIO ANKRD17 SMARCC2 SRCAP MBD5 ARID1A MEF2C

1.98e-04339207HP:0000213
HumanPhenoDiagnostic behavioral phenotype

HSPG2 SLITRK2 TRIO ANKRD17 SMARCC2 MED13L SRCAP MBD5 ARID1A MEF2C

1.98e-047472010HP:0025783
HumanPhenoLow anterior hairline

HSPG2 TRIO SMARCC2 MED13L ARID1A

2.04e-04147205HP:0000294
HumanPhenoAbnormal lower lip morphology

HSPG2 SMARCC2 MED13L SRCAP MBD5 ARID1A

2.39e-04242206HP:0000178
HumanPhenoThick eyebrow

TRIO SMARCC2 MBD5 ARID1A MEF2C

2.54e-04154205HP:0000574
HumanPhenoAbnormal 5th finger morphology

HSPG2 TRIO SMARCC2 MECOM SRCAP MBD5 ARID1A MEF2C

3.99e-04509208HP:0004207
HumanPhenoThick nasal alae

ANKRD17 SMARCC2 ARID1A

4.32e-0439203HP:0009928
HumanPhenoAggressive behavior

HSPG2 SLITRK2 TRIO SMARCC2 MED13L SRCAP MBD5 ARID1A

4.39e-04516208HP:0000718
HumanPhenoAbnormal aggressive, impulsive or violent behavior

HSPG2 SLITRK2 TRIO SMARCC2 MED13L SRCAP MBD5 ARID1A

4.39e-04516208HP:0006919
HumanPhenoAplasia/Hypoplasia involving the nose

TRIO SMARCC2 MED13L SRCAP MBD5 ARID1A MEF2C

5.59e-04401207HP:0009924
HumanPhenoPeriorbital fullness

TRIO ANKRD17 SRCAP

6.61e-0445203HP:0000629
HumanPhenoAbnormality of mouth size

HSPG2 TRIO SMARCC2 MED13L SRCAP MBD5 ARID1A

7.95e-04425207HP:0011337
MousePhenoabnormal prenatal growth/weight/body size

HSPG2 DDX12P ACACA ZNF296 AP2B1 TRIO ZC3H13 CBFA2T2 DAB2 ANKRD17 SMARCC2 MECOM PLAGL1 ISL1 MED13L BCL9 ARID1A MEF2C PRDM1

1.15e-0714934719MP:0004196
MousePhenoabnormal prenatal body size

HSPG2 DDX12P ACACA ZNF296 AP2B1 TRIO ZC3H13 CBFA2T2 DAB2 SMARCC2 MECOM PLAGL1 ISL1 BCL9 ARID1A PRDM1

3.43e-0711164716MP:0010866
MousePhenoabnormal embryonic growth/weight/body size

HSPG2 DDX12P ACACA ZNF296 AP2B1 TRIO ZC3H13 DAB2 ANKRD17 SMARCC2 MECOM ISL1 MED13L BCL9 ARID1A MEF2C PRDM1

4.55e-0712954717MP:0002088
MousePhenoabnormal embryo size

HSPG2 DDX12P ACACA ZNF296 AP2B1 TRIO ZC3H13 DAB2 SMARCC2 MECOM ISL1 BCL9 ARID1A PRDM1

1.81e-069564714MP:0001697
MousePhenodecreased primordial germ cell number

ZNF296 CBFA2T2 PRDM1

1.22e-0429473MP:0008392
MousePhenoeffusion

HSPG2 ANKRD17 MECOM ISL1 ARID1A

1.51e-04152475MP:0021205
MousePhenoabnormal primordial germ cell morphology

ZNF296 CBFA2T2 PRDM1

1.81e-0433473MP:0008391
DomainBiotin_lipoyl

ACACA DLAT

2.81e-049532PF00364
DomainBiotin_lipoyl

ACACA DLAT

3.50e-0410532IPR000089
DomainBIOTINYL_LIPOYL

ACACA DLAT

3.50e-0410532PS50968
DomainSingle_hybrid_motif

ACACA DLAT

5.12e-0412532IPR011053
DomainATP_grasp_subdomain_1

ACACA TTLL5

1.17e-0318532IPR013815
DomainBRCT_dom

SMARCC2 TP53BP1

2.85e-0328532IPR001357
DomainATP_grasp_subdomain_2

ACACA TTLL5

3.49e-0331532IPR013816
DomainCNMP_BINDING_1

KCNH6 CNBD1

3.71e-0332532PS00888
DomainCNMP_BINDING_2

KCNH6 CNBD1

3.71e-0332532PS00889
DomaincNMP_binding

KCNH6 CNBD1

4.18e-0334532PF00027
DomaincNMP-bd_dom

KCNH6 CNBD1

4.43e-0335532IPR000595
DomainCNMP_BINDING_3

KCNH6 CNBD1

4.43e-0335532PS50042
Domain-

RASAL3 TRIO DAB2 TNS4 SPATA13

4.93e-033915352.30.29.30
DomaincNMP-bd-like

KCNH6 CNBD1

5.20e-0338532IPR018490
DomainPTB

DAB2 TNS4

5.75e-0340532SM00462
DomainPTB/PI_dom

DAB2 TNS4

6.04e-0341532IPR006020
DomainPH_dom-like

RASAL3 TRIO DAB2 TNS4 SPATA13

7.05e-03426535IPR011993
Domain-

KCNH6 CNBD1

8.20e-03485322.60.120.10
DomainRmlC-like_jellyroll

KCNH6 CNBD1

9.22e-0351532IPR014710
DomainSH3_1

ABL2 TRIO SPATA13

1.13e-02164533PF00018
PathwayWP_KLEEFSTRA_SYNDROME

SMARCC2 MBD5 ARID1A

7.35e-0529403M48076
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

HIVEP3 HSPG2 RPAP1 ACACA ZNF296 TRIO MLLT10 MED13L BCL9 SRCAP MBD5 ARID1A SPATA13 ITPR3

2.71e-091105581435748872
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

FKBP15 AP2B1 TRIO PRR36 NHSL2 FAM120C ANKRD17 SMARCC2 BCL9 EMSY TP53BP1 SPATA13

5.24e-08963581228671696
Pubmed

Human transcription factor protein interaction networks.

HSPG2 NFYC DLAT ANKRD17 SMARCC2 MECOM MLLT10 BCL9 SRCAP ARID1A MEF2C EMSY TP53BP1 PRDM1

6.83e-081429581435140242
Pubmed

A human MAP kinase interactome.

ABL2 RASAL3 AP2B1 DAB2 NFYC ANKRD17 WWTR1 MBD5 MEF2C

1.10e-0748658920936779
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

RPAP1 ACACA ZC3H13 CBFA2T2 DAB2 ANKRD17 SMARCC2 BCL9 EMSY TP53BP1

5.60e-07774581015302935
Pubmed

Oct4 links multiple epigenetic pathways to the pluripotency network.

HSPG2 ANKRD17 SMARCC2 MLLT10 ARID1A TP53BP1

1.15e-0620358622083510
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

ACACA AP2B1 ZC3H13 DLAT ANKRD17 SMARCC2 ARID1A TP53BP1 ITPR3

1.29e-0665358922586326
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

CBFA2T2 NFYC ANKRD17 SMARCC2 MECOM WWTR1 ISL1 MEF2C EMSY TP53BP1

1.40e-06857581025609649
Pubmed

Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field.

ISL1 MEF2C ITPR3

1.58e-061458321382375
Pubmed

Enterovirus 71 VP1 promotes 5-HT release by upregulating the expression of ERICH3 and methyltransferase ZC3H13.

ERICH3 ZC3H13

2.73e-06258235660571
Pubmed

Classic bladder exstrophy and adenocarcinoma of the bladder: Methylome analysis provide no evidence for underlying disease-mechanisms of this association.

PLAGL1 ISL1

2.73e-06258231296310
Pubmed

Islet-1 may function as an assistant factor for histone acetylation and regulation of cardiac development-related transcription factor Mef2c expression.

ISL1 MEF2C

2.73e-06258224147056
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

HIVEP3 SOHLH2 ZNF296 ZC3H13 NFYC MLLT10 SRCAP ARID1A PRDM1

7.25e-0680858920412781
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

RASAL3 AP2B1 CBFA2T2 DAB2 MLLT10 BCL9 FAM186B

7.34e-0643058735044719
Pubmed

Identification of a novel GR-ARID1a-P53BP1 protein complex involved in DNA damage repair and cell cycle regulation.

ARID1A TP53BP1

8.19e-06358236344675
Pubmed

PRDM1/Blimp1 downregulates expression of germinal center genes LMO2 and HGAL.

GCSAM PRDM1

8.19e-06358221722313
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

ACACA ANKRD17 SMARCC2 SRCAP ARID1A TP53BP1 ITPR3

8.53e-0644058734244565
Pubmed

Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation.

WWTR1 ARID1A MEF2C

8.69e-062458337543677
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

FKBP15 SMARCC2 MED13L ARID1A EMSY

8.97e-0616758520362541
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

ACACA DAB2 MECOM WWTR1 BCL9

1.29e-0518058535198878
Pubmed

SWI/SNF protein component BAF250a regulates cardiac progenitor cell differentiation by modulating chromatin accessibility during second heart field development.

ISL1 ARID1A

1.64e-05458222621927
Pubmed

Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells.

DAB2 UNC13D

1.64e-05458218354201
Pubmed

Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages.

DAB2 WWTR1

1.64e-05458232651166
Pubmed

Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex.

SMARCC2 ARID1A

1.64e-05458217878164
Pubmed

Developmental diversification of cortical inhibitory interneurons.

PLAGL1 WWTR1 ISL1 MEF2C

1.67e-059158429513653
Pubmed

FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.

AP2B1 TRIO DAB2

1.91e-053158322323290
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

FAM120C SMARCC2 SRCAP ARID1A EMSY TP53BP1

2.24e-0534158632971831
Pubmed

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ.

WWTR1 ARID1A

2.72e-05558230401838
Pubmed

The HSA domain of BRG1 mediates critical interactions required for glucocorticoid receptor-dependent transcriptional activation in vivo.

SMARCC2 ARID1A

2.72e-05558218086889
Pubmed

Spatial and temporal changes in chondroitin sulfate distribution in the sclerotome play an essential role in the formation of migration patterns of mouse neural crest cells.

HSPG2 ISL1

2.72e-0555829915576
Pubmed

p300/CREB binding protein-related protein p270 is a component of mammalian SWI/SNF complexes.

SMARCC2 ARID1A

2.72e-0555829584200
Pubmed

Differential contribution of the two waves of cardiac progenitors and their derivatives to aorta and pulmonary artery.

ISL1 MEF2C

2.72e-05558230951706
Pubmed

Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation.

SMARCC2 ISL1 ARID1A

3.28e-053758324335282
Pubmed

Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.

AP2B1 TRIO DAB2 ANKRD17

3.65e-0511158422558309
Pubmed

Variations in the composition of mammalian SWI/SNF chromatin remodelling complexes.

SMARCC2 ARID1A

4.08e-05658219650111
Pubmed

Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex.

SMARCC2 ARID1A

4.08e-05658216940996
Pubmed

Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.

ISL1 MEF2C

4.08e-05658220691899
Pubmed

The p270 (ARID1A/SMARCF1) subunit of mammalian SWI/SNF-related complexes is essential for normal cell cycle arrest.

SMARCC2 ARID1A

4.08e-05658216230384
Pubmed

Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation.

HIVEP3 PLAGL1 MEF2C

4.49e-054158322147266
Pubmed

Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors.

ISL1 MEF2C

5.71e-05758224843018
Pubmed

Maternal epigenetic factors in embryonic and postnatal development.

MECOM MLLT10

5.71e-05758236906847
Pubmed

The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis.

SMARCC2 ARID1A

7.60e-05858236335117
Pubmed

Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development.

SMARCC2 ARID1A

7.60e-05858226986003
Pubmed

N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment.

ISL1 MEF2C

7.60e-05858225367124
Pubmed

Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development.

ISL1 MEF2C

7.60e-05858219035347
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

SMARCC2 MED13L BCL9 ARID1A EMSY

8.59e-0526858533640491
Pubmed

Coffin-Siris Syndrome

SMARCC2 ARID1A

9.77e-05958223556151
Pubmed

Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B.

SMARCC2 ARID1A

9.77e-05958220086098
Pubmed

The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds.

SMARCC2 ARID1A

9.77e-05958237805104
Pubmed

Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment.

ISL1 MEF2C

9.77e-05958224186978
Pubmed

Retinal ganglion cell axon sorting at the optic chiasm requires dystroglycan.

HSPG2 ISL1

9.77e-05958230149005
Pubmed

Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling.

SMARCC2 ARID1A

9.77e-0595829845365
Pubmed

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

SMARCC2 SRCAP ARID1A TP53BP1

1.18e-0415058428242625
Pubmed

Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.

SMARCC2 ARID1A

1.22e-041058212665591
Pubmed

A methylation-mediator complex in hormone signaling.

SMARCC2 ARID1A

1.22e-041058214729568
Pubmed

Cardiac neural crest and outflow tract defects in Lrp6 mutant mice.

ISL1 MEF2C

1.22e-041058219705442
Pubmed

Functional selectivity of recombinant mammalian SWI/SNF subunits.

SMARCC2 ARID1A

1.49e-041158211018012
Pubmed

Delta-like ligand 4-mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression.

ISL1 MEF2C

1.49e-041158232778568
Pubmed

Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors.

ISL1 MEF2C

1.49e-041158217576928
Pubmed

Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program.

SMARCC2 ARID1A

1.49e-041158218003620
Pubmed

Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development.

ISL1 MEF2C

1.49e-041158226489465
Pubmed

Developmental origin of the neuronal subtypes that comprise the amygdalar fear circuit in the mouse.

ISL1 MEF2C

1.78e-041258220484636
Pubmed

Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice.

ISL1 MEF2C

1.78e-041258228436940
Pubmed

PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation.

MECOM BCL9

1.78e-041258235132438
Pubmed

Hand1 regulates cardiomyocyte proliferation versus differentiation in the developing heart.

ISL1 MEF2C

1.78e-041258217050624
Pubmed

Kindlin-2 Is Essential for Preserving Integrity of the Developing Heart and Preventing Ventricular Rupture.

HSPG2 WWTR1

1.78e-041258230883226
Pubmed

SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones.

SMARCC2 ARID1A

1.78e-041258211734557
Pubmed

Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.

SMARCC2 ARID1A MEF2C

1.79e-046558326655900
Pubmed

Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo.

ISL1 PRDM1

2.11e-041358224821700
Pubmed

Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex.

SMARCC2 ARID1A

2.11e-041358211726552
Pubmed

Separation and Quantification of Some Alkaloids from Fumaria parviflora by Capillary Isotachophoresis1.

SMARCC2 ARID1A

2.11e-041358217340523
Pubmed

Global gene expression analysis in fetal mouse ovaries with and without meiosis and comparison of selected genes with meiosis in the testis.

RBPMS2 ANKRD17

2.11e-041358217431699
Pubmed

Graded mesoderm assembly governs cell fate and morphogenesis of the early mammalian heart.

ISL1 MEF2C

2.11e-041358236736300
Pubmed

Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.

NFYC SMARCC2 ARID1A TP53BP1

2.27e-0417858427637333
Pubmed

Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.

SMARCC2 ARID1A

2.46e-04145828895581
Pubmed

Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function.

ISL1 MEF2C

2.46e-041458236333314
Pubmed

Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways.

SMARCC2 ARID1A

2.83e-041558223785148
Pubmed

An essential switch in subunit composition of a chromatin remodeling complex during neural development.

SMARCC2 ARID1A

2.83e-041558217640523
Pubmed

The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression.

SMARCC2 ARID1A

2.83e-041558211263494
Pubmed

CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression.

ISL1 MEF2C

2.83e-041558237052590
Pubmed

Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation.

SMARCC2 ARID1A

2.83e-041558211175787
Pubmed

Trio controls the mature organization of neuronal clusters in the hindbrain.

TRIO ISL1

2.83e-041558217898204
Pubmed

PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes.

SMARCC2 ARID1A

2.83e-041558215985610
Pubmed

Regulation of dendritic development by neuron-specific chromatin remodeling complexes.

SMARCC2 ARID1A

2.83e-041558217920018
Pubmed

The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.

SOHLH2 WWTR1 ISL1 PRDM1

2.97e-0419158424146773
Pubmed

Interaction network of human early embryonic transcription factors.

SMARCC2 MECOM BCL9 ARID1A EMSY

3.01e-0435158538297188
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

ACACA WWTR1 SRCAP ARID1A EMSY TP53BP1

3.04e-0454958638280479
Pubmed

A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1.

SMARCC2 SRCAP

3.23e-041658211013263
Pubmed

Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development.

WWTR1 ISL1

3.23e-041658225433207
Pubmed

Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1).

SMARCC2 ARID1A

3.23e-041658211784859
Pubmed

Mutations in Hnrnpa1 cause congenital heart defects.

ISL1 MEF2C

3.23e-041658229367466
Pubmed

SWI/SNF complexes are required for retinal pigmented epithelium differentiation and for the inhibition of cell proliferation and neural differentiation programs.

SMARCC2 ISL1

3.23e-041658237522516
Pubmed

Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development.

ISL1 MEF2C

3.23e-041658215843409
Pubmed

A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.

ABL2 EMSY

3.23e-041658222036096
Pubmed

Identification of a polymorphic, neuron-specific chromatin remodeling complex.

SMARCC2 ARID1A

3.66e-041758212368262
Pubmed

Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein.

HSPG2 ISL1

3.66e-041758220970343
Pubmed

Identification of novel SHOX target genes in the developing limb using a transgenic mouse model.

ISL1 MEF2C

3.66e-041758224887312
Pubmed

The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.

SMARCC2 ARID1A

3.66e-041758211078522
Pubmed

Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with FoxA2 and Shh expression.

WWTR1 ISL1

3.66e-041758237315133
Pubmed

Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects.

ISL1 MEF2C

3.66e-041758219706423
InteractionTOP3B interactions

HIVEP3 HSPG2 RPAP1 ACACA ZNF296 TRIO FAM120C DLAT ANKRD17 MLLT10 MED13L BCL9 SRCAP MBD5 ARID1A TP53BP1 SPATA13 ITPR3

8.31e-0814705818int:TOP3B
InteractionPOU5F1 interactions

HSPG2 NFYC ANKRD17 SMARCC2 MLLT10 ARID1A EMSY TP53BP1 ITPR3 CC2D2B

5.77e-065845810int:POU5F1
InteractionETS1 interactions

SMARCC2 SRCAP ARID1A EMSY PRDM1

2.55e-05121585int:ETS1
InteractionSMG7 interactions

FAM120C ANKRD17 MECOM WWTR1 MLLT10 BCL9 ARID1A

3.51e-05319587int:SMG7
InteractionFAM193A interactions

FKBP15 AP2B1 FAM120C ANKRD17

5.20e-0571584int:FAM193A
InteractionKLHDC7B interactions

RBPMS2 NFYC TP53BP1

7.04e-0528583int:KLHDC7B
GeneFamilyZinc fingers C2H2-type|PR/SET domain family

MECOM PRDM1

5.44e-04173721197
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

ACACA TRIO MECOM MED13L MBD5 KIF13A MAML3

6.31e-091985771996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Mesenchymal|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

HSPG2 SLITRK2 DAB2 WWTR1 MEF2C ITPR3

1.74e-07193576e1de67ddada87229f5db0ec193a6da8745a86a64
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Mesenchymal-choroid_plexus/mesenchymal-like_cells|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

HSPG2 SLITRK2 DAB2 WWTR1 MEF2C ITPR3

1.74e-07193576b6f5a85210e60798205eaf5884cdb540f549d08a
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

HIVEP3 ACACA MECOM MED13L MBD5 MAML3

1.91e-07196576ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

ACACA TRIO MECOM MED13L MBD5 MAML3

2.09e-0719957694b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPG2 DAB2 MECOM WWTR1 MEF2C

4.82e-061935750f2967afbbf4e538b63f985c0acc2e5d9aab7589
ToppCellIPF-Endothelial-VE_Peribronchial|Endothelial / Disease state, Lineage and Cell class

HSPG2 ABL2 TRIO MECOM MEF2C

5.46e-06198575b8bd1ba268480f54451648e01631b615a3401144
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SPATC1 ZNF296 MAML3 GCSAM

3.21e-051415743fa3d2a8ebd9c285168ecea6db9cad74d3a3e85a
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SPATC1 ZNF296 MAML3 GCSAM

3.21e-05141574cabb5b8c0874813c713508af2ac620ab0d61ab6f
ToppCell3'-GW_trimst-1-LargeIntestine-Epithelial-neuro-epithelial-Progenitor_(NEUROG3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCNH6 ZNF296 PRR36 ISL1

4.41e-0515357420786807bba3bcd70ce744f8b6454e064199ed9f
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIVEP3 ACACA MBD5 KIF13A

5.00e-051585741d78578dc1f8ba43dacdccae1082c0b9d749f64d
ToppCelldroplet-Limb_Muscle-nan-24m-Myeloid-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIVEP3 KCNH6 PXT1 UNC13D

5.25e-05160574984990be02642a562f0c60ea99c01f005e7c02c2
ToppCellfacs-Marrow-KLS-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBPMS2 DAB2 ISL1 EMSY

5.65e-05163574b83a35c4426d66b5734a98fa6c72b345fe462030
ToppCellfacs-Marrow-KLS-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBPMS2 DAB2 ISL1 EMSY

5.65e-05163574c20ca9b6b4170ebcb0e66eef3e5d8ebff22b1a91
ToppCellfacs-Marrow-KLS-24m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBPMS2 DAB2 ISL1 EMSY

5.78e-05164574d2b5f51af7fcffddebe997ee302bacbd85d76852
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5|TCGA-Ovary / Sample_Type by Project: Shred V9

MBD5 ARID1A FAM186B MAML3

6.06e-0516657432d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NHSL2 MAML3 MEF2C CC2D2B

6.35e-05168574d60f7cd8269f373827f49c7785002cb38e4570a9
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NHSL2 MAML3 MEF2C CC2D2B

6.50e-05169574ccd98f9005aa0a88bd49f153be4e7200cc3dd0ac
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLITRK2 DLAT GCSAM PRDM1

6.50e-0516957401a24a8817628125bd004b2be68ffa62c7111f6e
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231|Adult / Lineage, Cell type, age group and donor

KCNH6 ACACA MECOM WWTR1

6.65e-05170574269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

HSPG2 MECOM WWTR1 MEF2C

8.12e-051795741ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCelldroplet-Liver-LIVER_HEP-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 MECOM ISL1 MEF2C

8.29e-05180574dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCelldroplet-Liver-LIVER_HEP|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 MECOM ISL1 MEF2C

8.29e-05180574423454e3390080ae03bb3cbb267255ebfe4df080
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SPATC1 OXER1 TRIO DAB2

8.84e-0518357436b194e366a14ebc4df187bf31c902be3797bfcc
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

TRIO ZC3H13 CBFA2T2 SPATA13

9.81e-0518857414bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCellCOVID-19-Heart-EC_(POSTN)|COVID-19 / Disease (COVID-19 only), tissue and cell type

HSPG2 NHSL2 MECOM WWTR1

1.00e-041895747346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCelldroplet-Tongue-nan-3m-Epithelial-filiform|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERICH3 ISL1 KIF13A SPATA13

1.02e-04190574251e3a33041023bfc4b547c7eb68cfb8f421636f
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-filiform|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERICH3 ISL1 KIF13A SPATA13

1.02e-041905748a53f4d3c9aca45b5826f53f7dcdfb8bc8280acb
ToppCellCOVID-19-Heart-EC_(POSTN)|Heart / Disease (COVID-19 only), tissue and cell type

HSPG2 NHSL2 MECOM WWTR1

1.06e-04192574c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

CBFA2T2 PLAGL1 MED13L MBD5

1.06e-04192574916fbec1c7ab7969bda711886ac88e877e30c280
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

TRIO ANKRD17 MED13L MBD5

1.06e-04192574e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 MECOM WWTR1 MEF2C

1.09e-04193574826b8dd801298b3e0cd76232feae5a14026b8806
ToppCellRV-10._Endothelium_II|RV / Chamber and Cluster_Paper

HSPG2 NHSL2 MECOM WWTR1

1.09e-0419357401c2df9206f1527c578e808978e58196c35e72f5
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TRIO ANKRD17 MED13L MAML3

1.09e-04193574779276e775cb2492e8dd36436295a536084a6415
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 MECOM WWTR1 MEF2C

1.09e-0419357487d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ABL2 MEF2C SPATA13 PRDM1

1.13e-04195574562e4c0e4e81f6303e57b846da71d1667fc35963
ToppCellwk_15-18-Epithelial-Distal_epithelial-type_II_pneumocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

HSPG2 PRR36 MECOM ITPR3

1.13e-041955740e3aac1b1a1fd483f5fb9a394eb90c0e1ce63542
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ABL2 MEF2C SPATA13 PRDM1

1.13e-04195574fa8ac154e5aebc26463ff84f0ad1038095770bc6
ToppCelldistal-Endothelial-Bronchial_Vessel_2-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HSPG2 MECOM WWTR1 MEF2C

1.17e-041975749fcfbfbe78e8fe90c76eb37a58ed9dc8ece652a1
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HIVEP3 ABL2 FAM186B MEF2C

1.22e-04199574b0a906586e58009f5ed9272fc29ba28e49c85ee6
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPG2 NHSL2 MECOM MEF2C

1.22e-04199574f0bf75bfae7b288ecb6801be458b03ebd0108ea7
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

HIVEP3 MED13L MAML3 MEF2C

1.24e-04200574a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellTCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

ABL2 AP2B1 TRIO BCL9

1.24e-042005741fa8422fd820d21e285a7e7c4c6fbd8b7277d2af
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

HIVEP3 MED13L MAML3 MEF2C

1.24e-04200574dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

HIVEP3 MED13L MAML3 MEF2C

1.24e-042005743bba5219453322198e8fdb0921d5f8c403598751
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

HIVEP3 MED13L MAML3 MEF2C

1.24e-0420057421bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

HIVEP3 MED13L MAML3 MEF2C

1.24e-04200574a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPG2 NHSL2 MECOM MEF2C

1.24e-0420057490061284a80d29a4ca6078f578e13d32b8cc80e1
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

HIVEP3 MED13L MAML3 MEF2C

1.24e-0420057433036d21c1c82109284473a515c4f890b33fdd5c
DrugVancomycin hydrochloride [1404-93-9]; Down 200; 2.6uM; MCF7; HT_HG-U133A

VPS9D1 HSPG2 TRIO CBFA2T2 WWTR1 ARID1A EMSY

6.53e-071965874423_DN
DrugLetrozole [112809-51-5]; Down 200; 14uM; MCF7; HT_HG-U133A

HIVEP3 PRR36 FAM120C TTLL5 ARID1A KIF13A EMSY

7.48e-072005874824_DN
DrugTiletamine hydrochloride; Down 200; 15.4uM; MCF7; HT_HG-U133A

HSPG2 ZC3H13 CBFA2T2 TTLL5 PLAGL1 EMSY

9.92e-061945866516_DN
DrugTrimeprazine tartrate [4330-99-8]; Up 200; 5.4uM; MCF7; HT_HG-U133A

HIVEP3 PRR36 PLAGL1 MLLT10 BCL9 EMSY

1.02e-051955863478_UP
DrugPramoxine hydrochloride [637-58-1]; Down 200; 12.2uM; MCF7; HT_HG-U133A

HIVEP3 HSPG2 RPAP1 PRR36 TTLL5 KIF13A

1.02e-051955864368_DN
DrugHexamethonium dibromide dihydrate [55-97-0]; Up 200; 10uM; MCF7; HT_HG-U133A

TRIO FAM120C ZC3H13 ISL1 SRCAP KIF13A

1.05e-051965864965_UP
DrugEsculin Hydrate [531-75-9]; Down 200; 11.8uM; MCF7; HT_HG-U133A

HSPG2 TRIO PLAGL1 WWTR1 SRCAP ARID1A

1.05e-051965863390_DN
DrugSulfamethizole [144-82-1]; Down 200; 14.8uM; PC3; HT_HG-U133A

HIVEP3 FKBP15 AP2B1 FAM120C MLLT10 BCL9

1.11e-051985865798_DN
DrugTetrahydroalstonine [6474-90-4]; Down 200; 11.4uM; HL60; HG-U133A

RPAP1 ANKRD17 SMARCC2 MED13L ARID1A MAML3

1.15e-051995861756_DN
Drug2-propylpentanoic acid; Up 200; 50uM; MCF7; HT_HG-U133A

VPS9D1 PRR36 ZC3H13 CBFA2T2 KIF13A PRDM1

1.15e-051995865219_UP
DrugMethylatropine nitrate [52-88-0]; Down 200; 11uM; MCF7; HT_HG-U133A

HIVEP3 HSPG2 AP2B1 FAM120C TTLL5 MECOM

1.15e-051995866495_DN
DrugDiphenylpyraline hydrochloride [132-18-3]; Down 200; 12.6uM; MCF7; HT_HG-U133A

VPS9D1 AP2B1 FAM120C ARID1A MEF2C EMSY

1.15e-051995864765_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

AP2B1 NFYC MED13L ARID1A EMSY

8.13e-051745857105_DN
DrugThioguanosine [85-31-4]; Up 200; 12.6uM; MCF7; HT_HG-U133A

TRIO ZC3H13 SRCAP MEF2C EMSY

1.00e-041825854989_UP
DrugThonzonium bromide [553-08-2]; Up 200; 6.8uM; MCF7; HT_HG-U133A

HIVEP3 VPS9D1 ABL2 SRCAP MEF2C

1.14e-041875855678_UP
DrugTubocurarine chloride pentahydrate (+) [6989-98-6]; Up 200; 5.2uM; MCF7; HT_HG-U133A

CBFA2T2 DAB2 MECOM PLAGL1 SRCAP

1.23e-041905852887_UP
Drugchlorpromazine hydrochloride; Down 200; 1uM; MCF7; HT_HG-U133A

TRIO CBFA2T2 TTLL5 MECOM PLAGL1

1.26e-041915855214_DN
Drug5707885; Down 200; 50uM; PC3; HT_HG-U133A

HIVEP3 PRR36 BCL9 SRCAP MEF2C

1.26e-041915856390_DN
Drughaloperidol; Down 200; 10uM; MCF7; HT_HG-U133A

AP2B1 TRIO TTLL5 NFYC EMSY

1.26e-041915855200_DN
DrugNaproxen [22204-53-1]; Down 200; 17.4uM; MCF7; HT_HG-U133A

RPAP1 TTLL5 WWTR1 BCL9 EMSY

1.26e-041915851706_DN
DrugAld1.1-H_000455; Up 200; 10uM; PC3; HT_HG-U133A

TRIO FAM120C SRCAP ARID1A EMSY

1.26e-041915857547_UP
DrugMidodrine hydrochloride [3092-17-9]; Down 200; 13.8uM; MCF7; HT_HG-U133A

AP2B1 TRIO TTLL5 BCL9 SRCAP

1.26e-041915852250_DN
DrugGSK-3 Inhibitor IX; Down 200; 0.5uM; PC3; HT_HG-U133A

AP2B1 SMARCC2 WWTR1 MED13L EMSY

1.29e-041925857106_DN
DrugSC 19220; Down 200; 10uM; PC3; HT_HG-U133A

HSPG2 CBFA2T2 TTLL5 SRCAP EMSY

1.29e-041925857065_DN
DrugClorgyline hydrochloride [17780-75-5]; Down 200; 13uM; PC3; HT_HG-U133A

HIVEP3 TRIO MLLT10 ARID1A MEF2C

1.29e-041925856659_DN
DrugC75; Down 200; 10uM; MCF7; HT_HG-U133A

VPS9D1 ABL2 AP2B1 TRIO BCL9

1.29e-041925856423_DN
DrugBeta-sistosterol [83-46-5]; Down 200; 9.6uM; MCF7; HT_HG-U133A

RPAP1 PRR36 CBFA2T2 BCL9 SRCAP

1.32e-041935854154_DN
DrugBromperidol [10457-90-6]; Up 200; 9.6uM; MCF7; HT_HG-U133A

HIVEP3 TRIO SRCAP ARID1A MEF2C

1.32e-041935852872_UP
Drugtrichostatin A; Down 200; 0.1uM; ssMCF7; HG-U133A

ACACA DAB2 MLLT10 MED13L ARID1A

1.32e-04193585413_DN
DrugMexiletine hydrochloride [5370-01-4]; Down 200; 18.6uM; MCF7; HT_HG-U133A

VPS9D1 PRR36 FAM120C CBFA2T2 SRCAP

1.32e-041935853973_DN
DrugCitalopram hydrobromide [59729-32-7]; Down 200; 1uM; MCF7; HT_HG-U133A

HIVEP3 VPS9D1 ABL2 SRCAP EMSY

1.36e-041945853903_DN
DrugEquilin [474-86-2]; Down 200; 15uM; MCF7; HT_HG-U133A

VPS9D1 TRIO PRR36 TTLL5 KIF13A

1.36e-041945853377_DN
DrugBetazole hydrochloride; Up 200; 27uM; PC3; HT_HG-U133A

ACACA AP2B1 MED13L BCL9 EMSY

1.36e-041945851812_UP
DrugDicumarol [66-76-2]; Down 200; 11.8uM; MCF7; HT_HG-U133A

HIVEP3 HSPG2 PRR36 CBFA2T2 SRCAP

1.39e-041955853941_DN
DrugPentamidine isethionate [140-64-7]; Down 200; 6.8uM; MCF7; HT_HG-U133A

HSPG2 ABL2 WWTR1 ARID1A EMSY

1.39e-041955854396_DN
DrugAmoxapine [14028-44-5]; Down 200; 12.8uM; MCF7; HT_HG-U133A

RPAP1 TRIO TTLL5 MLLT10 SRCAP

1.39e-041955854996_DN
DrugFlunisolide [3385-03-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A

AP2B1 TRIO PRR36 CBFA2T2 SRCAP

1.39e-041955853923_DN
Drug6-Furfurylaminopurine [525-79-1]; Up 200; 18.6uM; HL60; HT_HG-U133A

KCNH6 TTLL5 DAB2 MECOM WWTR1

1.42e-041965852511_UP
DrugIproniazide phosphate [305-33-9]; Down 200; 14.4uM; MCF7; HT_HG-U133A

HIVEP3 ABL2 FAM120C PLAGL1 SRCAP

1.42e-041965852288_DN
Drug(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Up 200; 11.8uM; MCF7; HT_HG-U133A

HIVEP3 WWTR1 MAML3 EMSY PRDM1

1.42e-041965856053_UP
DrugNadolol [42200-33-9]; Down 200; 13uM; MCF7; HT_HG-U133A

HIVEP3 VPS9D1 FAM120C TTLL5 SRCAP

1.42e-041965853359_DN
DrugNystatine [1400-61-9]; Up 200; 4.4uM; MCF7; HT_HG-U133A

KCNH6 FKBP15 TRIO CBFA2T2 ISL1

1.42e-041965854807_UP
DrugSolanine alpha [20562-02-1]; Up 200; 4.6uM; PC3; HT_HG-U133A

KCNH6 ZC3H13 MLLT10 SRCAP KIF13A

1.42e-041965854087_UP
DrugNefopam hydrochloride [23327-57-3]; Down 200; 13.8uM; MCF7; HT_HG-U133A

CBFA2T2 MLLT10 SRCAP KIF13A MEF2C

1.42e-041965854752_DN
DrugPregnenolone [145-13-1]; Down 200; 12.6uM; MCF7; HT_HG-U133A

HIVEP3 FAM120C TTLL5 MLLT10 BCL9

1.42e-041965854802_DN
DrugAmpyrone [83-07-8]; Down 200; 19.6uM; MCF7; HT_HG-U133A

AP2B1 TRIO TTLL5 SRCAP KIF13A

1.42e-041965852249_DN
DrugBenzonatate [104-31-4]; Down 200; 6.6uM; MCF7; HT_HG-U133A

RPAP1 PRR36 PLAGL1 WWTR1 BCL9

1.42e-041965851679_DN
DrugNS-398; Up 200; 10uM; MCF7; HT_HG-U133A

CBFA2T2 PLAGL1 WWTR1 MLLT10 KIF13A

1.42e-041965856911_UP
DrugEtilefrine hydrochloride [534-87-2]; Down 200; 18.4uM; MCF7; HT_HG-U133A

HIVEP3 ABL2 FAM120C CBFA2T2 SRCAP

1.42e-041965854415_DN
Drug6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine

DNHD1 ERICH3 PRR36 SRCAP

1.44e-04104584ctd:C000595015
DrugBetonicine [515-25-3]; Down 200; 25.2uM; MCF7; HT_HG-U133A

TRIO FAM120C ZC3H13 ARID1A EMSY

1.46e-041975854767_DN
DrugRiluzole hydrochloride; Up 200; 14.8uM; PC3; HT_HG-U133A

VPS9D1 AP2B1 TRIO ZC3H13 MLLT10

1.46e-041975853666_UP
Drugrosiglitazone; Up 200; 10uM; MCF7; HT_HG-U133A_EA

AP2B1 SMARCC2 MLLT10 ARID1A ITPR3

1.46e-041975851071_UP
DrugGlibenclamide [10238-21-8]; Down 200; 8uM; MCF7; HT_HG-U133A

CBFA2T2 MECOM PLAGL1 WWTR1 BCL9

1.46e-041975857202_DN
DrugKetoprofen [22071-15-4]; Down 200; 15.8uM; MCF7; HT_HG-U133A

ABL2 TTLL5 PLAGL1 BCL9 ARID1A

1.46e-041975854751_DN
DrugPrimidone [125-33-7]; Down 200; 18.4uM; HL60; HT_HG-U133A

VPS9D1 ABL2 TRIO WWTR1 ITPR3

1.46e-041975853065_DN
DrugC75; Down 200; 10uM; PC3; HT_HG-U133A

CBFA2T2 TTLL5 SMARCC2 MLLT10 SRCAP

1.46e-041975856428_DN
Drug15(S)-15-methyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A

HIVEP3 TRIO ZC3H13 TTLL5 PLAGL1

1.46e-041975857521_UP
DrugAmphotericin B [1397-89-3]; Up 200; 4.4uM; MCF7; HT_HG-U133A

VPS9D1 ZC3H13 CBFA2T2 PLAGL1 PRDM1

1.46e-041975853303_UP
DrugPiromidic acid [19562-30-2]; Down 200; 13.8uM; MCF7; HT_HG-U133A

HIVEP3 RPAP1 PRR36 PLAGL1 BCL9

1.46e-041975853335_DN
DrugEthamivan [304-84-7]; Up 200; 18uM; PC3; HT_HG-U133A

HIVEP3 AP2B1 FAM120C MAML3 EMSY

1.46e-041975857260_UP
Drug2-propylpentanoic acid; Down 200; 500uM; PC3; HT_HG-U133A

AP2B1 FAM120C NFYC WWTR1 MLLT10

1.46e-041975851240_DN
DrugChlorpheniramine maleate [113-92-8]; Up 200; 10.2uM; HL60; HG-U133A

SMARCC2 PLAGL1 MED13L SRCAP ARID1A

1.46e-041975851371_UP
DrugDienestrol [84-17-3]; Up 200; 15uM; PC3; HT_HG-U133A

KCNH6 ABL2 MLLT10 SRCAP MEF2C

1.49e-041985855727_UP
DrugProxyphylline [603-00-9]; Up 200; 16.8uM; MCF7; HT_HG-U133A

CBFA2T2 SRCAP ARID1A MEF2C ITPR3

1.49e-041985856494_UP
DrugDiphenylpyraline hydrochloride [132-18-3]; Up 200; 12.6uM; PC3; HT_HG-U133A

VPS9D1 KCNH6 ABL2 PRR36 SRCAP

1.49e-041985853743_UP
DrugNiridazole [61-57-4]; Up 200; 18.6uM; MCF7; HT_HG-U133A

HIVEP3 VPS9D1 ABL2 EMSY PRDM1

1.49e-041985855682_UP
DrugVitamin K2 [11032-49-8]; Down 200; 9uM; MCF7; HT_HG-U133A

HIVEP3 VPS9D1 FKBP15 FAM120C CBFA2T2

1.49e-041985853880_DN
DrugQuinic acid [86-68-0]; Down 200; 19.6uM; MCF7; HT_HG-U133A

ABL2 PLAGL1 ARID1A KIF13A EMSY

1.49e-041985853540_DN
DrugDO 897/99; Up 200; 8.2uM; MCF7; HT_HG-U133A

VPS9D1 TRIO FAM120C TTLL5 ITPR3

1.49e-041985857462_UP
DrugDL-PPMP; Up 200; 2uM; MCF7; HT_HG-U133A_EA

TRIO CBFA2T2 TTLL5 SMARCC2 MED13L

1.49e-041985851121_UP
DrugZidovudine, AZT [30516-87-1]; Up 200; 15uM; MCF7; HT_HG-U133A

HIVEP3 CBFA2T2 PLAGL1 SRCAP ARID1A

1.49e-041985853211_UP
Drugdiclofenac sodium; Down 200; 10uM; PC3; HG-U133A

ACACA TRIO SMARCC2 BCL9 MEF2C

1.49e-04198585445_DN
Drug11-deoxy-16,16-dimethyl Prostaglandin E2; Down 200; 10uM; PC3; HT_HG-U133A

HIVEP3 TTLL5 WWTR1 KIF13A EMSY

1.49e-041985857519_DN
DrugMetampicillin sodium salt [6489-61-8]; Down 200; 10.4uM; MCF7; HT_HG-U133A

VPS9D1 TRIO TTLL5 SRCAP KIF13A

1.49e-041985852286_DN
DrugDeltaline [6836-11-9]; Up 200; 7.8uM; MCF7; HT_HG-U133A

HIVEP3 HSPG2 TRIO DAB2 SRCAP

1.49e-041985853831_UP
DrugFolic acid [59-30-3]; Down 200; 9uM; PC3; HT_HG-U133A

HIVEP3 AP2B1 TRIO SMARCC2 ITPR3

1.53e-041995855844_DN
Drug3-aminobenzamide; Down 200; 10000uM; MCF7; HG-U133A

DLAT SMARCC2 WWTR1 SRCAP TP53BP1

1.53e-04199585590_DN
DrugOxalamine citrate salt [1949-20-8]; Down 200; 9.2uM; PC3; HT_HG-U133A

FKBP15 TRIO FAM120C CBFA2T2 BCL9

1.53e-041995856624_DN
DrugMoxisylyte hydrochoride [964-52-3]; Down 200; 12.6uM; MCF7; HT_HG-U133A

RPAP1 TTLL5 WWTR1 BCL9 SRCAP

1.56e-042005851682_DN
DrugPromazine hydrochloride [53-60-1]; Up 200; 12.4uM; MCF7; HT_HG-U133A

ZC3H13 CBFA2T2 MLLT10 SRCAP EMSY

1.56e-042005853833_UP
DrugThiamphenicol [15318-45-3]; Up 200; 11.2uM; MCF7; HT_HG-U133A

VPS9D1 PLAGL1 WWTR1 KIF13A EMSY

1.56e-042005851704_UP
DrugBendroflumethiazide [73-48-3]; Up 200; 9.4uM; MCF7; HT_HG-U133A

HIVEP3 CBFA2T2 SRCAP ITPR3 PRDM1

1.56e-042005853840_UP
DrugNifurtimox [23256-30-6]; Up 200; 14uM; MCF7; HT_HG-U133A

VPS9D1 TRIO CBFA2T2 TTLL5 SRCAP

1.56e-042005854953_UP
DrugSB 203580; Up 200; 1uM; MCF7; HT_HG-U133A

VPS9D1 RPAP1 PLAGL1 MLLT10 KIF13A

1.56e-042005856899_UP
Drug1,4-bis-(phenoxyacetyl)piperazine

AP2B1 DAB2 MECOM UNC13D MLLT10

2.70e-04225585CID001008511
DrugSuccimer

HIVEP3 ZNF296 ZC3H13 CBFA2T2 DAB2 DLAT MECOM MLLT10 MEF2C SPATA13 PRDM1

3.02e-0412645811ctd:D004113
DrugMagnetite Nanoparticles

HIVEP3 ZNF296 ZC3H13 CBFA2T2 DAB2 DLAT MECOM MLLT10 MEF2C SPATA13 PRDM1

4.10e-0413105811ctd:D058185
Drugirinotecan HCl; Down 200; 100uM; PC3; HT_HG-U133A

TRIO ANKRD17 MED13L MEF2C

9.50e-041715847535_DN
DrugI-Hg

CBFA2T2 GCSAM

1.06e-0319582CID000447029
DrugSTOCK1N-35215; Up 200; 10uM; PC3; HT_HG-U133A

FKBP15 ABL2 TRIO KIF13A

1.20e-031825846427_UP
Drug17-AAG; Up 200; 1uM; PC3; HT_HG-U133A

FKBP15 ABL2 MLLT10 EMSY

1.22e-031835841206_UP
DrugF0447-0125; Down 200; 10uM; PC3; HT_HG-U133A

CBFA2T2 TTLL5 WWTR1 MLLT10

1.25e-031845846429_DN
Drug0179445-0000 [211246-22-9]; Up 200; 10uM; MCF7; HT_HG-U133A

KCNH6 ABL2 FAM120C SRCAP

1.25e-031845844755_UP
DrugClomiphene citrate (Z,E) [50-41-9]; Up 200; 6.6uM; MCF7; HT_HG-U133A

VPS9D1 TRIO MECOM SRCAP

1.25e-031845844994_UP
DrugICI 182,780; Down 200; 1uM; MCF7; HT_HG-U133A

AP2B1 TRIO DLAT MED13L

1.27e-031855846965_DN
Drug17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A

FAM120C SMARCC2 MECOM BCL9

1.27e-031855845585_DN
DrugWithaferin A [5119-48-2]; Down 200; 1uM; MCF7; HT_HG-U133A

HIVEP3 FAM120C TTLL5 MECOM

1.30e-031865843902_DN
DrugTPGS

DLAT MLLT10

1.30e-0321582CID000071406
DrugLevonordefrin [829-74-3]; Up 200; 21.8uM; PC3; HT_HG-U133A

TRIO CBFA2T2 MLLT10 KIF13A

1.32e-031875845854_UP
DiseaseNeurodevelopmental Disorders

HIVEP3 TRIO MED13L SRCAP MEF2C

1.03e-0693575C1535926
DiseaseCoffin-Siris syndrome (implicated_via_orthology)

SMARCC2 ARID1A

1.31e-049572DOID:1925 (implicated_via_orthology)
Diseaseascending aortic diameter

HIVEP3 UNC13D MED13L MBD5

1.58e-04140574EFO_0021787
Diseaseadult onset asthma, body mass index

UNC13D PLAGL1

1.63e-0410572EFO_0004340, EFO_1002011
DiseaseCoffin-Siris syndrome

SMARCC2 ARID1A

2.82e-0413572C0265338
Diseaseliver volume

ARID1A TP53BP1

3.79e-0415572EFO_0600048
Diseasemonocyte percentage of leukocytes

RASAL3 MECOM PLAGL1 MED13L MBD5 ARID1A MEF2C

5.02e-04731577EFO_0007989
Diseaseeosinophil count

SPATC1 HIVEP3 RASAL3 UNC13D PLAGL1 MBD5 EMSY TP53BP1 GCSAM ITPR3

5.10e-0414885710EFO_0004842
Diseasemultisite chronic pain

MLLT10 MAML3 ITPR3

8.34e-0495573EFO_0010100
DiseaseAdenoid Cystic Carcinoma

SRCAP ARID1A MAML3

9.68e-04100573C0010606
Diseasemultiple myeloma

SOHLH2 MECOM SRCAP

1.34e-03112573EFO_0001378
Diseaseglomerular filtration rate, response to platinum based chemotherapy

WWTR1 BCL9

1.34e-0328572EFO_0004647, EFO_0005208
Diseaseadult onset asthma

UNC13D PLAGL1 EMSY

1.56e-03118573EFO_1002011
Diseaseseasonal allergic rhinitis

ABL2 EMSY

1.75e-0332572EFO_0003956
DiseaseAcute Myeloid Leukemia, M1

TRIO MECOM MLLT10

1.84e-03125573C0026998
DiseaseAcute Myeloid Leukemia (AML-M2)

TRIO MECOM MLLT10

1.84e-03125573C1879321
Diseasechronic obstructive pulmonary disease

RPAP1 MECOM BCL9 KIF13A MAML3 EMSY

2.08e-03688576EFO_0000341
Diseaseovarian neoplasm

MECOM BCL9 TP53BP1

2.24e-03134573C0919267
DiseaseMalignant neoplasm of ovary

MECOM BCL9 TP53BP1

2.39e-03137573C1140680
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

DNHD1 MLLT10 ARID1A

2.97e-03148573C0279702
Diseaseretinal vasculature measurement

HSPG2 TRIO TTLL5 MED13L MEF2C

3.21e-03517575EFO_0010554
DiseaseNeuroblastoma

ISL1 ARID1A

3.75e-0347572C0027819

Protein segments in the cluster

PeptideGeneStartEntry
RSVENNMPILSPHPP

ERICH3

111

Q5RHP9
PSTPLAIHTPLMPNQ

AP2B1

766

P63010
PPPVMRLLQHPSICS

ABL2

986

P42684
PSPHMPRPNQTILVD

BRICD5

71

Q6PL45
QFMLPTSHPNRGNIP

ACACA

1181

Q13085
ISSHFLQQPRPLMAP

GCSAM

156

Q8N6F7
SPSHPQPLSPEQMLQ

FAM186B

186

Q8IYM0
RPHLPMSPSTQQPAL

FAM186B

591

Q8IYM0
HSQATQPMLILLPPP

DNHD1

4081

Q96M86
PLSPARATNSPKPHM

ANKRD17

1931

O75179
NGLPLIPMPQSLRSS

CC2D2B

631

Q6DHV5
KLMATPNPSNVHPAL

RBPMS2

116

Q6ZRY4
VPMRLPLPPAQVHSS

RASAL3

746

Q86YV0
TIMRQPPVTHAPQPL

HSPG2

261

P98160
RLPNNHSTASPLGMP

ITPR3

2401

Q14573
SPLMTHPQILPATQD

MECOM

526

Q03112
PSMQNHIPQVSSPAP

ARID1A

1576

O14497
TQPPSMHSSLLVTPP

DAB2

606

P98082
NLNPMDSPHSPISPL

MED13L

541

Q71F56
LQRMFPTPPSLEQHP

MED13L

861

Q71F56
LPSNMPLPSASPLHQ

MAML3

206

Q96JK9
PELLQEMPPRHSPQS

KCNH6

796

Q9H252
APRHSPALTVPLMNP

CBFA2T2

266

O43439
HQKVPLPSLSPTMQA

DLAT

91

P10515
HPALPQMTSQAPQPS

FKBP15

416

Q5T1M5
PLAHPSLQRNSMSPG

MEF2C

171

Q06413
LPGMTSLSPLHPSQQ

NFYC

406

Q13952
PKQPMELHNLSSPSP

OXER1

36

Q8TDS5
LNPMAPPSRQGSELH

ERVK-10

251

P87889
NSRLSHMPPLPLNPS

BCL9

811

O00512
PSMLNPANVPTHLLL

FAM120C

751

Q9NX05
SQASVPQPASPLMHI

DDX12P

571

Q92771
MALGNSLHPNPPQSR

MBD5

801

Q9P267
QSIANSLPPHMSPVK

EMSY

246

Q7Z589
RPLLSQESMPPPQAH

KIF13A

1486

Q9H1H9
HSLTLSPPEQAAQPM

PLAGL1

261

Q9UM63
TLAMPPRSSIQHARP

NHSL2

901

Q5HYW2
SHSPQAPLSSLIMPP

PRR36

696

Q9H6K5
HVQRLSPTMNPALNP

SLITRK2

281

Q9H156
LPHPMLNPTSLPSSL

PRDM1

456

O75626
PLSPLHPARPLQMAA

ISL1

146

P61371
MQSSPSPAHPQLPVL

SRCAP

1

Q6ZRS2
PVSMANPLHPNLPAT

SMARCC2

1136

Q8TAQ2
NPLHPNLPATTTMPS

SMARCC2

1141

Q8TAQ2
MSQNPTPLTHTTVPP

MLLT10

926

P55197
LSHMTAINNVPPPPL

CNBD1

11

Q8NA66
LTQPASRPPMPAHQV

SPATA13

46

Q96N96
SRMHNSPTQNLPVPH

SPATC1

366

Q76KD6
RNPTLTMGQPRTPHS

TNS4

336

Q8IZW8
TAPPVPLLRSHSMPS

HIVEP3

531

Q5T1R4
HTIRQSQQPMKPISP

TP53BP1

1081

Q12888
PRELSTHPPQPLSMQ

RPAP1

706

Q9BWH6
THPPQPLSMQRIASL

RPAP1

711

Q9BWH6
RPSQSLHCMLSPPEP

VPS9D1

326

Q9Y2B5
TNQNISIHLPSAMPP

SOHLH2

381

Q9NX45
SQPVPAMSRNPDHNL

PXT1

46

Q8NFP0
MATLLSHPQQRPPFL

UNC13D

1

Q70J99
IPSAIPSMPHQPTIL

TTLL5

921

Q6EMB2
SPQRKQSPPRHRSPM

ZC3H13

381

Q5T200
PPMAIQQHSLLQPDS

TRIO

1871

O75962
MNLHPAVSSTPVPQR

WWTR1

166

Q9GZV5
HRQVPPQSPLMADTS

ZNF296

281

Q8WUU4