Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	hexokinase activity	HK1 HK2	1.38e-05	5	24	2	GO:0004396
GeneOntologyMolecularFunction	glucokinase activity	HK1 HK2	1.38e-05	5	24	2	GO:0004340
GeneOntologyMolecularFunction	fructokinase activity	HK1 HK2	1.38e-05	5	24	2	GO:0008865
GeneOntologyMolecularFunction	D-glucose binding	HK1 HK2	1.25e-04	14	24	2	GO:0005536
GeneOntologyMolecularFunction	carbohydrate kinase activity	HK1 HK2	2.87e-04	21	24	2	GO:0019200
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme activity	UBE2D2 UBE2D3	8.99e-04	37	24	2	GO:0061631
GeneOntologyMolecularFunction	ubiquitin-like protein conjugating enzyme activity	UBE2D2 UBE2D3	1.21e-03	43	24	2	GO:0061650
GeneOntologyMolecularFunction	carboxypeptidase activity	CPB1 PRCP	1.57e-03	49	24	2	GO:0004180
GeneOntologyMolecularFunction	monosaccharide binding	HK1 HK2	5.77e-03	95	24	2	GO:0048029
GeneOntologyMolecularFunction	carbohydrate binding	GBE1 HK1 HK2	5.89e-03	310	24	3	GO:0030246
GeneOntologyMolecularFunction	exopeptidase activity	CPB1 PRCP	7.67e-03	110	24	2	GO:0008238
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	TRIM69 UBE2D2 UBE2D3	9.71e-03	372	24	3	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	TRIM69 UBE2D2 UBE2D3	1.17e-02	398	24	3	GO:0061659
GeneOntologyBiologicalProcess	maintenance of protein location in mitochondrion	HK1 HK2	1.19e-05	5	23	2	GO:0072656
GeneOntologyBiologicalProcess	protein K29-linked ubiquitination	UBE2D2 UBE2D3	9.21e-05	13	23	2	GO:0035519
GeneOntologyBiologicalProcess	protein K27-linked ubiquitination	UBE2D2 UBE2D3	1.07e-04	14	23	2	GO:0044314
GeneOntologyBiologicalProcess	fructose 6-phosphate metabolic process	HK1 HK2	1.41e-04	16	23	2	GO:0006002
GeneOntologyBiologicalProcess	protein K6-linked ubiquitination	UBE2D2 UBE2D3	1.60e-04	17	23	2	GO:0085020
GeneOntologyBiologicalProcess	NADH regeneration	HK1 HK2	2.47e-04	21	23	2	GO:0006735
GeneOntologyBiologicalProcess	canonical glycolysis	HK1 HK2	2.47e-04	21	23	2	GO:0061621
GeneOntologyBiologicalProcess	glucose catabolic process to pyruvate	HK1 HK2	2.47e-04	21	23	2	GO:0061718
GeneOntologyBiologicalProcess	NAD catabolic process	HK1 HK2	3.51e-04	25	23	2	GO:0019677
GeneOntologyBiologicalProcess	carbohydrate phosphorylation	HK1 HK2	3.51e-04	25	23	2	GO:0046835
GeneOntologyBiologicalProcess	glycolytic process through glucose-6-phosphate	HK1 HK2	3.51e-04	25	23	2	GO:0061620
GeneOntologyBiologicalProcess	establishment of protein localization to mitochondrion	HK1 UBE2D3 HK2	4.22e-04	133	23	3	GO:0072655
GeneOntologyBiologicalProcess	glucose homeostasis	HK1 HK2 FOXA3 PRCP	4.90e-04	338	23	4	GO:0042593
GeneOntologyBiologicalProcess	carbohydrate homeostasis	HK1 HK2 FOXA3 PRCP	4.96e-04	339	23	4	GO:0033500
GeneOntologyBiologicalProcess	protein localization to mitochondrion	HK1 UBE2D3 HK2	5.01e-04	141	23	3	GO:0070585
GeneOntologyBiologicalProcess	glycolytic process through fructose-6-phosphate	HK1 HK2	5.42e-04	31	23	2	GO:0061615
GeneOntologyBiologicalProcess	glucose 6-phosphate metabolic process	HK1 HK2	5.78e-04	32	23	2	GO:0051156
GeneOntologyBiologicalProcess	glucose catabolic process	HK1 HK2	5.78e-04	32	23	2	GO:0006007
GeneOntologyBiologicalProcess	protein K11-linked ubiquitination	UBE2D2 UBE2D3	7.74e-04	37	23	2	GO:0070979
GeneOntologyBiologicalProcess	NADH metabolic process	HK1 HK2	9.97e-04	42	23	2	GO:0006734
GeneOntologyBiologicalProcess	maintenance of protein localization in organelle	HK1 HK2	1.25e-03	47	23	2	GO:0072595
GeneOntologyBiologicalProcess	lactation	FOXB1 HK2	1.30e-03	48	23	2	GO:0007595
GeneOntologyBiologicalProcess	hexose catabolic process	HK1 HK2	1.58e-03	53	23	2	GO:0019320
GeneOntologyBiologicalProcess	intracellular glucose homeostasis	HK1 HK2 FOXA3	1.76e-03	218	23	3	GO:0001678
GeneOntologyBiologicalProcess	monosaccharide catabolic process	HK1 HK2	1.83e-03	57	23	2	GO:0046365
Domain	Hexokinase_C	HK1 HK2	1.58e-05	5	24	2	IPR022673
Domain	Hexokinase_N	HK1 HK2	1.58e-05	5	24	2	IPR022672
Domain	Hexokinase_1	HK1 HK2	1.58e-05	5	24	2	PF00349
Domain	HEXOKINASE_2	HK1 HK2	1.58e-05	5	24	2	PS51748
Domain	Hexokinase_2	HK1 HK2	1.58e-05	5	24	2	PF03727
Domain	Hexokinase_BS	HK1 HK2	1.58e-05	5	24	2	IPR019807
Domain	HEXOKINASE_1	HK1 HK2	1.58e-05	5	24	2	PS00378
Domain	Hexokinase	HK1 HK2	2.37e-05	6	24	2	IPR001312
Domain	TF_fork_head_CS_2	FOXB1 FOXA3 FOXB2	2.73e-05	46	24	3	IPR030456
Domain	TF_fork_head_CS_1	FOXB1 FOXA3 FOXB2	2.91e-05	47	24	3	IPR018122
Domain	FORK_HEAD_3	FOXB1 FOXA3 FOXB2	3.30e-05	49	24	3	PS50039
Domain	FH	FOXB1 FOXA3 FOXB2	3.30e-05	49	24	3	SM00339
Domain	FORK_HEAD_1	FOXB1 FOXA3 FOXB2	3.30e-05	49	24	3	PS00657
Domain	FORK_HEAD_2	FOXB1 FOXA3 FOXB2	3.30e-05	49	24	3	PS00658
Domain	Forkhead	FOXB1 FOXA3 FOXB2	3.30e-05	49	24	3	PF00250
Domain	Fork_head_dom	FOXB1 FOXA3 FOXB2	3.30e-05	49	24	3	IPR001766
Domain	UBQ-conjugating_AS	UBE2D2 UBE2D3	4.66e-04	25	24	2	IPR023313
Domain	UQ_con	UBE2D2 UBE2D3	1.14e-03	39	24	2	PF00179
Domain	UBIQUITIN_CONJUGAT_1	UBE2D2 UBE2D3	1.20e-03	40	24	2	PS00183
Domain	UBIQUITIN_CONJUGAT_2	UBE2D2 UBE2D3	1.26e-03	41	24	2	PS50127
Domain	UBQ-conjugat_E2	UBE2D2 UBE2D3	1.26e-03	41	24	2	IPR000608
Domain	-	UBE2D2 UBE2D3	1.94e-03	51	24	2	3.10.110.10
Domain	UBQ-conjugating_enzyme/RWD	UBE2D2 UBE2D3	2.10e-03	53	24	2	IPR016135
Domain	-	FOXB1 FOXA3 FOXB2	2.65e-03	218	24	3	1.10.10.10
Domain	WHTH_DNA-bd_dom	FOXB1 FOXA3 FOXB2	3.56e-03	242	24	3	IPR011991
Pathway	WP_GLYCOGEN_SYNTHESIS_AND_DEGRADATION	GBE1 HK1 HK2	1.40e-05	40	17	3	M39595
Pathway	KEGG_MEDICUS_PATHOGEN_SHIGELLA_FIMA_TO_CROSSTALK_BETWEEN_EXTRINSIC_AND_INTRINSIC_APOPTOTIC_PATHWAYS	HK1 HK2	2.05e-05	6	17	2	M47654
Pathway	KEGG_STARCH_AND_SUCROSE_METABOLISM	GBE1 HK1 HK2	3.10e-05	52	17	3	M14171
Pathway	WP_UDPDERIVED_SUGARS_SYNTHESIS_IN_FIBROBLASTS	HK1 HK2	7.48e-05	11	17	2	M48094
Pathway	REACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING	UBE2D2 UBE2D3	2.07e-04	18	17	2	MM15680
Pathway	REACTOME_TICAM1_RIP1_MEDIATED_IKK_COMPLEX_RECRUITMENT	UBE2D2 UBE2D3	2.31e-04	19	17	2	M27020
Pathway	REACTOME_METABOLISM_OF_CARBOHYDRATES	GBE1 ST3GAL2 HK1 HK2	2.61e-04	271	17	4	MM15406
Pathway	REACTOME_SIGNALING_BY_CSF3_G_CSF	UBE2D2 UBE2D3	3.12e-04	22	17	2	MM15675
Pathway	REACTOME_METABOLISM_OF_CARBOHYDRATES	GBE1 ST3GAL2 HK1 HK2	3.29e-04	288	17	4	M16864
Pathway	REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1	UBE2D2 UBE2D3	3.41e-04	23	17	2	M1003
Pathway	REACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING	UBE2D2 UBE2D3	4.04e-04	25	17	2	M41829
Pathway	REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1	UBE2D2 UBE2D3	4.04e-04	25	17	2	MM15646
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	TRIM69 UBE2D2 UBE2D3 ASB15	4.25e-04	308	17	4	M1070
Pathway	KEGG_GALACTOSE_METABOLISM	HK1 HK2	4.37e-04	26	17	2	M4377
Pathway	REACTOME_SIGNALING_BY_CSF3_G_CSF	UBE2D2 UBE2D3	5.84e-04	30	17	2	M41825
Pathway	REACTOME_PINK1_PRKN_MEDIATED_MITOPHAGY	UBE2D2 UBE2D3	6.65e-04	32	17	2	M27419
Pathway	KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM	HK1 HK2	7.51e-04	34	17	2	M15898
Pathway	REACTOME_PINK1_PRKN_MEDIATED_MITOPHAGY	UBE2D2 UBE2D3	7.51e-04	34	17	2	MM15167
Pathway	REACTOME_NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING	UBE2D2 UBE2D3	7.96e-04	35	17	2	M985
Pathway	REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION	TRIM69 UBE2D2 UBE2D3 ASB15	9.45e-04	381	17	4	M1066
Pathway	REACTOME_MITOPHAGY	UBE2D2 UBE2D3	9.88e-04	39	17	2	M27418
Pathway	PID_ERBB1_INTERNALIZATION_PATHWAY	UBE2D2 UBE2D3	1.09e-03	41	17	2	M214
Pathway	REACTOME_MITOPHAGY	UBE2D2 UBE2D3	1.09e-03	41	17	2	MM15166
Pathway	WP_METABOLIC_REPROGRAMMING_IN_PANCREATIC_CANCER	HK1 HK2	1.15e-03	42	17	2	M45531
Pathway	KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM	HK1 HK2	1.26e-03	44	17	2	M8104
Pathway	WP_GLYCOLYSIS_AND_GLUCONEOGENESIS	HK1 HK2	1.31e-03	45	17	2	M39474
Pathway	REACTOME_E3_UBIQUITIN_LIGASES_UBIQUITINATE_TARGET_PROTEINS	UBE2D2 UBE2D3	1.31e-03	45	17	2	MM15508
Pathway	KEGG_TYPE_II_DIABETES_MELLITUS	HK1 HK2	1.43e-03	47	17	2	M19708
Pathway	REACTOME_REGULATION_OF_TNFR1_SIGNALING	UBE2D2 UBE2D3	1.43e-03	47	17	2	MM15179
Pathway	WP_GLYCOLYSIS_AND_GLUCONEOGENESIS	HK1 HK2	1.69e-03	51	17	2	MM15928
Pathway	REACTOME_TNF_SIGNALING	UBE2D2 UBE2D3	2.03e-03	56	17	2	MM15453
Pathway	WP_PROTEASOME_DEGRADATION	UBE2D2 UBE2D3	2.03e-03	56	17	2	MM15901
Pathway	REACTOME_TNF_SIGNALING	UBE2D2 UBE2D3	2.10e-03	57	17	2	M27713
Pathway	REACTOME_E3_UBIQUITIN_LIGASES_UBIQUITINATE_TARGET_PROTEINS	UBE2D2 UBE2D3	2.25e-03	59	17	2	M27763
Pathway	KEGG_GLYCOLYSIS_GLUCONEOGENESIS	HK1 HK2	2.48e-03	62	17	2	M11521
Pathway	WP_PROTEASOME_DEGRADATION	UBE2D2 UBE2D3	2.48e-03	62	17	2	M39639
Pathway	REACTOME_PEROXISOMAL_PROTEIN_IMPORT	UBE2D2 UBE2D3	2.56e-03	63	17	2	M27915
Pathway	REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS	ST3GAL2 HK1	2.64e-03	64	17	2	M892
Pathway	REACTOME_PROTEIN_UBIQUITINATION	UBE2D2 UBE2D3	2.72e-03	65	17	2	MM15490
Pathway	REACTOME_PEROXISOMAL_PROTEIN_IMPORT	UBE2D2 UBE2D3	2.72e-03	65	17	2	MM15628
Pathway	PID_HIF1_TFPATHWAY	HK1 HK2	2.81e-03	66	17	2	M255
Pathway	REACTOME_NEDDYLATION	UBE2D2 UBE2D3 ASB15	2.94e-03	245	17	3	M27822
Pathway	REACTOME_CELLULAR_RESPONSE_TO_HYPOXIA	UBE2D2 UBE2D3	3.06e-03	69	17	2	MM14522
Pathway	REACTOME_SELECTIVE_AUTOPHAGY	UBE2D2 UBE2D3	3.42e-03	73	17	2	MM15672
Pathway	REACTOME_CELLULAR_RESPONSE_TO_HYPOXIA	UBE2D2 UBE2D3	3.61e-03	75	17	2	M641
Pathway	REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN	ST3GAL2 HK1	3.80e-03	77	17	2	MM15118
Pathway	REACTOME_PROTEIN_UBIQUITINATION	UBE2D2 UBE2D3	3.99e-03	79	17	2	M27742
Pathway	REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN	ST3GAL2 HK1	3.99e-03	79	17	2	M897
Pathway	REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA	UBE2D2 UBE2D3	4.30e-03	82	17	2	M1002
Pathway	REACTOME_GLUCOSE_METABOLISM	HK1 HK2	4.30e-03	82	17	2	MM15394
Pathway	REACTOME_GLUCOSE_METABOLISM	HK1 HK2	4.61e-03	85	17	2	M1870
Pathway	WP_CLEAR_CELL_RENAL_CELL_CARCINOMA_PATHWAYS	HK1 HK2	4.71e-03	86	17	2	M39375
Pathway	REACTOME_SELECTIVE_AUTOPHAGY	UBE2D2 UBE2D3	5.15e-03	90	17	2	M29841
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	TRIM69 UBE2D2 UBE2D3	5.15e-03	299	17	3	MM15711
Pathway	WP_METABOLIC_EPILEPTIC_DISORDERS	HK1 HK2	5.26e-03	91	17	2	M48079
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	ST3GAL2 SGPL1	5.38e-03	92	17	2	MM15086
Pathway	REACTOME_PROTEIN_LOCALIZATION	UBE2D2 UBE2D3	6.69e-03	103	17	2	MM15653
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	ST3GAL2 SGPL1	7.21e-03	107	17	2	M14857
Pathway	WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING	HK2 WNT10B	7.34e-03	108	17	2	M48078
Pathway	REACTOME_MYD88_INDEPENDENT_TLR4_CASCADE	UBE2D2 UBE2D3	7.47e-03	109	17	2	M29565
Pathway	REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION	TRIM69 UBE2D2 UBE2D3	7.54e-03	343	17	3	MM15712
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_4_TLR4_CASCADE	UBE2D2 UBE2D3	9.28e-03	122	17	2	MM14640
Pathway	REACTOME_MACROAUTOPHAGY	UBE2D2 UBE2D3	1.05e-02	130	17	2	MM14627
Pathway	KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS	UBE2D2 UBE2D3	1.13e-02	135	17	2	M15247
Pathway	KEGG_INSULIN_SIGNALING_PATHWAY	HK1 HK2	1.16e-02	137	17	2	M18155
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	UBE2D2 UBE2D3	1.24e-02	142	17	2	MM15431
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	UBE2D2 UBE2D3	1.45e-02	154	17	2	M27697
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_CASCADES	UBE2D2 UBE2D3	1.47e-02	155	17	2	MM14665
Pathway	REACTOME_AUTOPHAGY	UBE2D2 UBE2D3	1.52e-02	158	17	2	M27935
Pathway	REACTOME_ADAPTIVE_IMMUNE_SYSTEM	TRIM69 UBE2D2 UBE2D3 ASB15	1.52e-02	828	17	4	M1058
Pathway	REACTOME_PROTEIN_LOCALIZATION	UBE2D2 UBE2D3	1.63e-02	164	17	2	M27932
Pubmed	Six members of the mouse forkhead gene family are developmentally regulated.	FOXB1 FOXA3 FOXB2	1.48e-07	15	25	3	7689224
Pubmed	The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia-reperfusion injury.	HK1 HK2	4.96e-07	2	25	2	21504994
Pubmed	Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury.	HK1 HK2	4.96e-07	2	25	2	24990892
Pubmed	Characterising the dynamics of placental glycogen stores in the mouse.	GBE1 HK1 HK2	1.18e-06	29	25	3	32798765
Pubmed	Structural and functional characterization of hMEX-3C Ring finger domain as an E3 ubiquitin ligase.	UBE2D2 UBE2D3	1.49e-06	3	25	2	30095198
Pubmed	Effect of Increased IL-1β on Expression of HK in Alzheimer's Disease.	HK1 HK2	1.49e-06	3	25	2	33525649
Pubmed	Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.	HK1 HK2	1.49e-06	3	25	2	19049977
Pubmed	[Evaluation of Gene Expression of Hexokinases in Colorectal Cancer with the Use of Bioinformatics Methods].	HK1 HK2	1.49e-06	3	25	2	26855992
Pubmed	Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress.	HK1 HK2	1.49e-06	3	25	2	21430642
Pubmed	A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis.	HK1 HK2	1.49e-06	3	25	2	20347420
Pubmed	Fubp1 supports the lactate-Akt-mTOR axis through the upregulation of Hk1 and Hk2.	HK1 HK2	1.49e-06	3	25	2	30871777
Pubmed	Identification of a family of closely related human ubiquitin conjugating enzymes.	UBE2D2 UBE2D3	1.49e-06	3	25	2	8530467
Pubmed	c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.	HK1 HK2	1.49e-06	3	25	2	28054552
Pubmed	Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity.	UBE2D2 UBE2D3	1.49e-06	3	25	2	11912157
Pubmed	Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1.	UBE2D2 UBE2D3	2.97e-06	4	25	2	9535861
Pubmed	Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4.	UBE2D2 UBE2D3	2.97e-06	4	25	2	20696396
Pubmed	Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.	HK1 HK2	2.97e-06	4	25	2	25904018
Pubmed	Physical and functional interactions between ZIP kinase and UbcH5.	UBE2D2 UBE2D3	2.97e-06	4	25	2	18515077
Pubmed	Hexokinase activity is required for recruitment of parkin to depolarized mitochondria.	HK1 HK2	2.97e-06	4	25	2	23962723
Pubmed	High 18F-FDG uptake in PMAH correlated with normal expression of Glut1, HK1, HK2, and HK3.	HK1 HK2	2.97e-06	4	25	2	25766729
Pubmed	The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity.	UBE2D2 UBE2D3	2.97e-06	4	25	2	31241013
Pubmed	Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program.	HK1 HK2	2.97e-06	4	25	2	32152094
Pubmed	Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.	UBE2D2 UBE2D3	4.95e-06	5	25	2	25327252
Pubmed	Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis.	UBE2D2 UBE2D3	4.95e-06	5	25	2	23509263
Pubmed	The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.	UBE2D2 UBE2D3	4.95e-06	5	25	2	14562029
Pubmed	Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak.	HK1 HK2	4.95e-06	5	25	2	15574336
Pubmed	E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1).	UBE2D2 UBE2D3	4.95e-06	5	25	2	15684077
Pubmed	Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.	UBE2D2 UBE2D3	4.95e-06	5	25	2	10329681
Pubmed	Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.	UBE2D2 UBE2D3	4.95e-06	5	25	2	26502057
Pubmed	Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism.	UBE2D2 UBE2D3	4.95e-06	5	25	2	23408431
Pubmed	The RING domain of mitochondrial E3 ubiquitin ligase 1 and its complex with Ube2D2: crystallization and X-ray diffraction.	UBE2D2 UBE2D3	4.95e-06	5	25	2	31929179
Pubmed	A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95.	UBE2D2 UBE2D3	4.95e-06	5	25	2	18313049
Pubmed	Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation.	UBE2D2 UBE2D3	4.95e-06	5	25	2	19741096
Pubmed	ADP-ribosylation factor domain protein 1 (ARD1), a multifunctional protein with ubiquitin E3 ligase, GAP, and ARF domains.	UBE2D2 UBE2D3	4.95e-06	5	25	2	16413270
Pubmed	Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.	UBE2D2 UBE2D3	4.95e-06	5	25	2	8090726
Pubmed	Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes.	UBE2D2 UBE2D3	7.43e-06	6	25	2	9990509
Pubmed	Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.	UBE2D2 UBE2D3	7.43e-06	6	25	2	27678051
Pubmed	NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway.	UBE2D2 UBE2D3	7.43e-06	6	25	2	33962630
Pubmed	Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.	UBE2D2 UBE2D3	7.43e-06	6	25	2	15280377
Pubmed	Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114.	UBE2D2 UBE2D3	7.43e-06	6	25	2	28625874
Pubmed	Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.	UBE2D2 UBE2D3	7.43e-06	6	25	2	22124327
Pubmed	h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes.	UBE2D2 UBE2D3	7.43e-06	6	25	2	16549277
Pubmed	The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2.	UBE2D2 UBE2D3	7.43e-06	6	25	2	25701873
Pubmed	Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons.	UBE2D2 UBE2D3	7.43e-06	6	25	2	22976837
Pubmed	Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation.	TRIM69 UBE2D3	7.43e-06	6	25	2	23131556
Pubmed	Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology.	UBE2D2 UBE2D3	7.43e-06	6	25	2	30404641
Pubmed	Genome-wide atlas of gene expression in the adult mouse brain.	FOXB1 FOXA3 FOXB2	7.94e-06	54	25	3	17151600
Pubmed	Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain.	FOXB1 FOXA3 FOXB2	9.36e-06	57	25	3	21122108
Pubmed	Measuring rates of ubiquitin chain formation as a functional readout of ligase activity.	UBE2D2 UBE2D3	1.04e-05	7	25	2	22350887
Pubmed	Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.	UBE2D2 UBE2D3	1.04e-05	7	25	2	11714696
Pubmed	In Vitro Analysis of E3 Ubiquitin Ligase Function.	UBE2D2 UBE2D3	1.04e-05	7	25	2	34057440
Pubmed	Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate.	UBE2D2 UBE2D3	1.04e-05	7	25	2	20347421
Pubmed	Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver.	HK1 HK2	1.04e-05	7	25	2	18165236
Pubmed	Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation.	UBE2D2 UBE2D3	1.04e-05	7	25	2	22613722
Pubmed	Bifunctional apoptosis regulator (BAR), an endoplasmic reticulum (ER)-associated E3 ubiquitin ligase, modulates BI-1 protein stability and function in ER Stress.	UBE2D2 UBE2D3	1.04e-05	7	25	2	21068390
Pubmed	The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.	UBE2D2 UBE2D3	1.04e-05	7	25	2	21685362
Pubmed	RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand.	UBE2D2 UBE2D3	1.04e-05	7	25	2	20553626
Pubmed	Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.	UBE2D2 UBE2D3	1.04e-05	7	25	2	20051513
Pubmed	Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.	UBE2D2 UBE2D3	1.04e-05	7	25	2	24831002
Pubmed	UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I.	UBE2D2 UBE2D3	1.04e-05	7	25	2	17719635
Pubmed	A ubiquitin ligase complex assembles linear polyubiquitin chains.	UBE2D2 UBE2D3	1.04e-05	7	25	2	17006537
Pubmed	The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu.	UBE2D2 UBE2D3	1.04e-05	7	25	2	25278022
Pubmed	Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.	UBE2D2 UBE2D3	1.04e-05	7	25	2	28322253
Pubmed	Analysis of the Zn-Binding Domains of TRIM32, the E3 Ubiquitin Ligase Mutated in Limb Girdle Muscular Dystrophy 2H.	UBE2D2 UBE2D3	1.04e-05	7	25	2	30884854
Pubmed	The E3 Ubiquitin Ligase NEDD4L Targets OGG1 for Ubiquitylation and Modulates the Cellular DNA Damage Response.	UBE2D2 UBE2D3	1.04e-05	7	25	2	33282879
Pubmed	MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.	UBE2D2 UBE2D3	1.39e-05	8	25	2	25207814
Pubmed	Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.	UBE2D2 UBE2D3	1.39e-05	8	25	2	15247280
Pubmed	E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.	UBE2D2 UBE2D3	1.39e-05	8	25	2	24446487
Pubmed	The mechanism of neural precursor cell expressed developmentally down-regulated 4-2 (Nedd4-2)/NEDD4L-catalyzed polyubiquitin chain assembly.	UBE2D2 UBE2D3	1.39e-05	8	25	2	28972136
Pubmed	Ube2W conjugates ubiquitin to α-amino groups of protein N-termini.	UBE2D2 UBE2D3	1.39e-05	8	25	2	23560854
Pubmed	Involvement of Rabring7 in EGF receptor degradation as an E3 ligase.	UBE2D2 UBE2D3	1.39e-05	8	25	2	17462600
Pubmed	Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.	UBE2D2 UBE2D3	1.39e-05	8	25	2	18838541
Pubmed	A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control.	UBE2D2 UBE2D3	1.39e-05	8	25	2	16682404
Pubmed	Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.	UBE2D2 UBE2D3	1.39e-05	8	25	2	14661060
Pubmed	The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins.	FOXB1 FOXA3	1.39e-05	8	25	2	8306889
Pubmed	Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase.	UBE2D2 UBE2D3	1.39e-05	8	25	2	28681414
Pubmed	Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7.	UBE2D2 UBE2D3	1.39e-05	8	25	2	29323787
Pubmed	The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.	UBE2D2 UBE2D3	1.39e-05	8	25	2	12670957
Pubmed	Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO.	UBE2D2 UBE2D3	1.78e-05	9	25	2	12525502
Pubmed	Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.	UBE2D2 UBE2D3	1.78e-05	9	25	2	17460044
Pubmed	Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma.	HK1 HK2	1.78e-05	9	25	2	19554504
Pubmed	Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice.	HK1 HK2	1.78e-05	9	25	2	21074528
Pubmed	Comparison of Cross-Regulation by Different OTUB1:E2 Complexes.	UBE2D2 UBE2D3	1.78e-05	9	25	2	32049508
Pubmed	TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase.	UBE2D2 UBE2D3	1.78e-05	9	25	2	17544371
Pubmed	Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181.	UBE2D2 UBE2D3	1.78e-05	9	25	2	26711259
Pubmed	E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP.	UBE2D2 UBE2D3	2.22e-05	10	25	2	21518764
Pubmed	Bag1 directly routes immature BCR-ABL for proteasomal degradation.	UBE2D2 UBE2D3	2.22e-05	10	25	2	20675402
Pubmed	Inflammasome activation and metabolic remodelling in p16-positive aging cells aggravates high-fat diet-induced lung fibrosis by inhibiting NEDD4L-mediated K48-polyubiquitin-dependent degradation of SGK1.	UBE2D2 UBE2D3	2.22e-05	10	25	2	37345264
Pubmed	Proteomics identifies the developmental regulation of HKDC1 in liver of pigs and mice.	HK1 HK2	2.22e-05	10	25	2	37545422
Pubmed	Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells.	UBE2D2 UBE2D3	2.22e-05	10	25	2	28757353
Pubmed	Tripartite motif containing 69 elicits ERK2-dependent EYA4 turnover to impart pancreatic tumorigenesis.	TRIM69 UBE2D3	2.22e-05	10	25	2	36741265
Pubmed	Mechanism and chain specificity of RNF216/TRIAD3, the ubiquitin ligase mutated in Gordon Holmes syndrome.	UBE2D2 UBE2D3	2.22e-05	10	25	2	31087003
Pubmed	Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib.	UBE2D2 UBE2D3	2.22e-05	10	25	2	33607208
Pubmed	A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing.	UBE2D2 UBE2D3	2.72e-05	11	25	2	36027913
Pubmed	Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates.	UBE2D2 UBE2D3	2.72e-05	11	25	2	24438103
Pubmed	Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase.	UBE2D2 UBE2D3	2.72e-05	11	25	2	22334663
Pubmed	Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination.	UBE2D2 UBE2D3	2.72e-05	11	25	2	19712108
Pubmed	The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.	UBE2D2 UBE2D3	3.26e-05	12	25	2	24211586
Pubmed	E1-E2 interactions in ubiquitin and Nedd8 ligation pathways.	UBE2D2 UBE2D3	3.26e-05	12	25	2	22069333
Pubmed	Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding.	UBE2D2 UBE2D3	3.26e-05	12	25	2	24905733
Interaction	HK3 interactions	FOXB1 HK1 HK2	6.25e-06	35	21	3	int:HK3
Interaction	FBXO2 interactions	UBE2D2 UBE2D3 HK2 PRCP WNT10B	5.35e-05	411	21	5	int:FBXO2
Interaction	MARCHF5 interactions	UBE2D2 HK1 UBE2D3 SGPL1	5.43e-05	205	21	4	int:MARCHF5
Interaction	ARK2C interactions	UBE2D2 UBE2D3	6.78e-05	12	21	2	int:ARK2C
Interaction	RNF146 interactions	UBE2D2 HK1 UBE2D3	6.79e-05	77	21	3	int:RNF146
Interaction	RNF122 interactions	UBE2D2 UBE2D3	1.23e-04	16	21	2	int:RNF122
Interaction	TOPORS interactions	UBE2D2 UBE2D3 ZNF786	1.31e-04	96	21	3	int:TOPORS
Interaction	UBE4A interactions	FOXB1 UBE2D2 UBE2D3	1.91e-04	109	21	3	int:UBE4A
Interaction	RNF150 interactions	UBE2D2 UBE2D3	1.94e-04	20	21	2	int:RNF150
Interaction	ZNRF4 interactions	UBE2D2 UBE2D3 SGPL1	1.96e-04	110	21	3	int:ZNRF4
Interaction	UBOX5 interactions	UBE2D2 UBE2D3	2.58e-04	23	21	2	int:UBOX5
Interaction	TOMM40 interactions	FOXB1 FOXA3 PRCP SGPL1	2.64e-04	309	21	4	int:TOMM40
Interaction	PYGL interactions	GBE1 HK1 HK2	2.86e-04	125	21	3	int:PYGL
Interaction	ST3GAL2 interactions	ST3GAL2 FOXA3	3.06e-04	25	21	2	int:ST3GAL2
Interaction	POLM interactions	UBE2D2 UBE2D3	3.31e-04	26	21	2	int:POLM
Interaction	AREL1 interactions	UBE2D2 UBE2D3	3.57e-04	27	21	2	int:AREL1
Interaction	HK2 interactions	FOXB1 HK1 HK2	3.58e-04	135	21	3	int:HK2
Interaction	RNF103 interactions	UBE2D2 UBE2D3	4.13e-04	29	21	2	int:RNF103
Interaction	CADPS2 interactions	UBE2D2 UBE2D3	4.42e-04	30	21	2	int:CADPS2
Interaction	WSB1 interactions	UBE2D2 UBE2D3	4.72e-04	31	21	2	int:WSB1
Interaction	UBA6 interactions	MTRR UBE2D2 UBE2D3	4.87e-04	150	21	3	int:UBA6
Interaction	TRIM62 interactions	UBE2D2 UBE2D3	5.03e-04	32	21	2	int:TRIM62
Interaction	BIRC8 interactions	UBE2D2 UBE2D3	5.03e-04	32	21	2	int:BIRC8
Interaction	TRIM45 interactions	UBE2D2 UBE2D3	5.36e-04	33	21	2	int:TRIM45
Interaction	TRIM17 interactions	UBE2D2 UBE2D3	5.69e-04	34	21	2	int:TRIM17
Interaction	DTX1 interactions	UBE2D2 UBE2D3	6.03e-04	35	21	2	int:DTX1
Interaction	ZNRF1 interactions	UBE2D2 UBE2D3	6.38e-04	36	21	2	int:ZNRF1
Interaction	UVSSA interactions	UBE2D2 UBE2D3	6.74e-04	37	21	2	int:UVSSA
Interaction	HECW1 interactions	UBE2D2 UBE2D3	6.74e-04	37	21	2	int:HECW1
Interaction	DDX39A interactions	C8orf76 GBE1 FOXB1 TRIM69 FOXA3 PRCP	7.45e-04	1114	21	6	int:DDX39A
Interaction	UBTD1 interactions	UBE2D2 UBE2D3	7.88e-04	40	21	2	int:UBTD1
Interaction	RNF220 interactions	UBE2D2 UBE2D3	8.68e-04	42	21	2	int:RNF220
Interaction	RNF25 interactions	UBE2D2 UBE2D3	9.10e-04	43	21	2	int:RNF25
Interaction	MARCHF3 interactions	UBE2D2 UBE2D3	9.10e-04	43	21	2	int:MARCHF3
Interaction	UBA52 interactions	UBE2D2 HK1 UBE2D3 PHF3	9.74e-04	437	21	4	int:UBA52
Interaction	FBXO4 interactions	UBE2D2 UBE2D3	1.04e-03	46	21	2	int:FBXO4
Interaction	TRIM38 interactions	UBE2D2 UBE2D3	1.09e-03	47	21	2	int:TRIM38
Interaction	ZNRF2 interactions	UBE2D2 UBE2D3	1.09e-03	47	21	2	int:ZNRF2
Interaction	UHRF2 interactions	UBE2D2 UBE2D3 PHF3	1.12e-03	200	21	3	int:UHRF2
Interaction	TRIM10 interactions	UBE2D2 UBE2D3	1.13e-03	48	21	2	int:TRIM10
Interaction	BFAR interactions	UBE2D2 UBE2D3	1.13e-03	48	21	2	int:BFAR
Interaction	TRIM50 interactions	UBE2D2 UBE2D3	1.18e-03	49	21	2	int:TRIM50
Interaction	RNF14 interactions	UBE2D2 UBE2D3	1.18e-03	49	21	2	int:RNF14
Interaction	RMND5B interactions	UBE2D2 UBE2D3	1.18e-03	49	21	2	int:RMND5B
Interaction	FOXA3 interactions	ST3GAL2 FOXA3	1.33e-03	52	21	2	int:FOXA3
Interaction	RNF216 interactions	UBE2D2 UBE2D3	1.33e-03	52	21	2	int:RNF216
Interaction	RNF125 interactions	UBE2D2 UBE2D3	1.38e-03	53	21	2	int:RNF125
Interaction	TRIM43 interactions	UBE2D2 UBE2D3	1.38e-03	53	21	2	int:TRIM43
Interaction	TRIM2 interactions	UBE2D2 UBE2D3	1.38e-03	53	21	2	int:TRIM2
Interaction	RNF167 interactions	UBE2D2 UBE2D3	1.43e-03	54	21	2	int:RNF167
Interaction	MYLIP interactions	UBE2D2 UBE2D3	1.54e-03	56	21	2	int:MYLIP
Interaction	RNF34 interactions	UBE2D2 UBE2D3	1.54e-03	56	21	2	int:RNF34
Interaction	BIRC7 interactions	UBE2D2 UBE2D3	1.59e-03	57	21	2	int:BIRC7
Interaction	SLC15A3 interactions	HK1 HK2 SGPL1	1.76e-03	234	21	3	int:SLC15A3
Interaction	CHFR interactions	UBE2D2 UBE2D3	1.77e-03	60	21	2	int:CHFR
Interaction	RNF26 interactions	UBE2D2 UBE2D3	1.77e-03	60	21	2	int:RNF26
Interaction	RNF13 interactions	UBE2D2 UBE2D3	1.77e-03	60	21	2	int:RNF13
Interaction	HIC2 interactions	FOXB1 FOXA3	1.82e-03	61	21	2	int:HIC2
Interaction	SKIC8 interactions	HK1 HK2 ASB15	1.87e-03	239	21	3	int:SKIC8
Interaction	MARCHF8 interactions	UBE2D3 HK2	1.88e-03	62	21	2	int:MARCHF8
Interaction	HEXB interactions	HK1 HK2	2.01e-03	64	21	2	int:HEXB
Interaction	PELI1 interactions	UBE2D2 UBE2D3	2.07e-03	65	21	2	int:PELI1
Interaction	CNOT4 interactions	UBE2D2 UBE2D3	2.07e-03	65	21	2	int:CNOT4
Interaction	DTX3L interactions	UBE2D2 UBE2D3	2.26e-03	68	21	2	int:DTX3L
Interaction	ESRRB interactions	HK1 PHF3 SGPL1	2.43e-03	262	21	3	int:ESRRB
Cytoband	Ensembl 112 genes in cytogenetic band chr10q22	HK1 SGPL1	5.72e-03	208	25	2	chr10q22
GeneFamily	Forkhead boxes	FOXB1 FOXA3 FOXB2	6.87e-06	43	16	3	508
GeneFamily	Carboxypeptidases	CPB1 PRCP	1.53e-04	21	16	2	1321
GeneFamily	Ubiquitin conjugating enzymes E2	UBE2D2 UBE2D3	5.90e-04	41	16	2	102
ToppCell	FLU-Healthy-4\|Healthy / Virus stimulation, Condition and Cluster	GBE1 TRIM69 HK1 HK2	4.37e-06	199	25	4	40061131e35131873192ca65c0e731a7b3045636
Computational	Genes in the cancer module 4.	UBE2D2 UBE2D3	2.80e-04	21	13	2	MODULE_4
Computational	Genes in the cancer module 233.	UBE2D2 UBE2D3	3.08e-04	22	13	2	MODULE_233
Computational	Genes in the cancer module 82.	UBE2D2 UBE2D3	3.67e-04	24	13	2	MODULE_82
Computational	Neighborhood of WBSCR22	ST3GAL2 WNT10B	8.31e-04	36	13	2	CAR_WBSCR22
Computational	Proteasome.	UBE2D2 UBE2D3	8.78e-04	37	13	2	MODULE_91
Computational	Neighborhood of MLANA	ST3GAL2 WNT10B	1.19e-03	43	13	2	CAR_MLANA
Computational	Genes upregulated in subsets of cells of a given type within various tumors	GBE1 HK2	1.60e-03	50	13	2	GAVISH_3CA_MALIGNANT_METAPROGRAM_METAPROGRAM_6_HYPOXIA
Drug	NSC 226836	CPB1 HK1 HK2	1.32e-06	20	25	3	CID000012600
Drug	N-bromoacetylglucosamine	HK1 HK2	6.94e-06	4	25	2	CID000152920
Drug	2,3-anhydro-D-allose	HK1 HK2	6.94e-06	4	25	2	CID000191595
Drug	1,5-anhydroglucitol 6-phosphate	HK1 HK2	6.94e-06	4	25	2	CID003081444
Drug	1-deoxy-D-manno-heptulose	HK1 HK2	6.94e-06	4	25	2	CID000193198
Drug	lofenal	HK1 HK2	6.94e-06	4	25	2	CID000159256
Drug	AC1L5VHN	HK1 HK2	6.94e-06	4	25	2	CID000235938
Drug	3-chloromethylthiochromone-1,1-dioxide	HK1 HK2	1.16e-05	5	25	2	CID000100620
Drug	2-fluoro-2-deoxy-6-phosphogluconate	HK1 HK2	1.16e-05	5	25	2	CID000127270
Drug	8-thiocyano-ATP	HK1 HK2	1.73e-05	6	25	2	CID000132196
Drug	glucitol-6-phosphate	HK1 HK2 SGPL1	2.08e-05	49	25	3	CID000000618
Drug	fructose-1,6-diphosphate sodium salt	GBE1 HK1 HK2 SGPL1	2.11e-05	151	25	4	CID000000718
Drug	glucose 6-arsenate	HK1 HK2	2.42e-05	7	25	2	CID000128033
Drug	AC1L5A5F	HK1 HK2	2.42e-05	7	25	2	CID000173497
Drug	Leucocianidol	GBE1 HK1	3.23e-05	8	25	2	CID000071629
Drug	AFDG	HK1 HK2	3.23e-05	8	25	2	CID000164297
Drug	tetrahydropyran-2-methanol	HK1 HK2	3.23e-05	8	25	2	CID000007524
Drug	ATP-EDC	HK1 HK2	5.18e-05	10	25	2	CID000195647
Drug	NSC-334019	CPB1 PRCP	6.33e-05	11	25	2	CID000100090
Drug	first rate	HK1 HK2	6.33e-05	11	25	2	CID000086453
Drug	Rotenone	MTRR UBE2D2 HK1 UBE2D3 HK2 PHF3 SGPL1	6.43e-05	978	25	7	ctd:D012402
Drug	AC1Q6SXM	HK1 HK2 SGPL1	8.75e-05	79	25	3	CID000000717
Drug	triethyltin bromide	HK1 HK2	8.96e-05	13	25	2	CID000017701
Drug	AC1Q6HGX	HK1 HK2	1.20e-04	15	25	2	CID000000600
Drug	galactosone	HK1 HK2	1.38e-04	16	25	2	CID000097398
Drug	AC1L9A1P	CPB1 HK1	1.38e-04	16	25	2	CID000440846
Drug	morpholine-citrate	HK1 HK2	1.75e-04	18	25	2	CID000173845
Drug	bromopyruvate	HK1 HK2	1.75e-04	18	25	2	ctd:C017092
Drug	alloxan	GBE1 HK1 HK2	2.04e-04	105	25	3	CID000005781
Drug	o-toluidine	HK1 HK2	2.17e-04	20	25	2	CID000007242
Drug	2-deoxy-D-glucose 6-phosphate	HK1 HK2	2.40e-04	21	25	2	CID000440992
Drug	AC1NDP1U	GBE1 HK1 HK2	2.66e-04	115	25	3	CID004629339
Drug	dimethyl-3,3'-dithiobispropionimidate	MTRR HK1	3.42e-04	25	25	2	CID000123988
Drug	2-deoxy-2-fluoro-D-talose	HK1 HK2	3.70e-04	26	25	2	CID000068614
Disease	obesity (is_implicated_in)	HK1 HK2 WNT10B	4.19e-05	91	22	3	DOID:9970 (is_implicated_in)
Disease	glucose metabolism disease (implicated_via_orthology)	HK1 HK2	1.98e-04	28	22	2	DOID:4194 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease	HK1 SGPL1	4.49e-04	42	22	2	cv:C0007959
Disease	acute lymphoblastic leukemia (is_implicated_in)	MTRR HK1	7.69e-04	55	22	2	DOID:9952 (is_implicated_in)
Disease	multiple myeloma (is_implicated_in)	MTRR HK1	8.85e-04	59	22	2	DOID:9538 (is_implicated_in)
Disease	sleep apnea measurement	HK1 ASB15	3.36e-03	116	22	2	EFO_0007817
Disease	Myocardial Ischemia	HK1 HK2	7.56e-03	176	22	2	C0151744

Protein segments in the cluster

Peptide	Gene	Start	Entry
FTGFGKCAGIWNHMD	AGPAT4-IT1	36	Q9H0P7
FDCMHGDIFGNSFVW	ASB15	446	Q8WXK1
MDSGCWLFGGEFEDS	C8orf76	1	Q96K31
FWALHPDCGDMFENG	FOXB2	86	Q5VYV0
HPDGNFGAMWLFFGC	MTRR	566	Q9UBK8
NMEWGAFGDNGCLDD	HK2	706	P52789
FCTNGVDDMFEPHSW	PRCP	371	P42785
NHDWPFGPGLCMFCF	GPR174	81	Q9BXC1
NMEWGAFGDNGCLDD	HK1	706	P19367
FWALHPSCGDMFENG	FOXB1	86	Q99853
LNFMGNEFGHPEWLD	GBE1	536	Q04446
MDCGFHAREWISPAF	CPB1	171	P15086
GLEDFHMWISGPFCS	OR52J3	21	Q8NH60
WALHPSSGNMFENGC	FOXA3	191	P55318
MGDAGASDWFDSHFD	ST3GAL2	76	Q16842
DRNGSWHPGFNCEFF	SHISA4	36	Q96DD7
SAACWAALMHFGENG	SGPL1	401	O95470
DWFRDPLMLSCGHNF	TRIM69	46	Q86WT6
CSAGPVGDDMFHWQA	UBE2D2	21	P62837
CGSDFYMAPEVWEGH	STK35	416	Q8TDR2
CSAGPVGDDMFHWQA	UBE2D3	21	P61077
FMVGCGRCDDWFHGD	PHF3	731	Q92576
DMHFDPGFEEQLFWG	ZNF786	86	Q8N393
PRCLMNGEWGYHFED	TM4SF5	116	O14894
WGGCNHDMDFGEKFS	WNT10B	196	O00744