Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionneurotransmitter receptor activity

HTR2A GRIK4 GRIN2C CHRM2 CHRM3

3.97e-05100765GO:0030594
GeneOntologyMolecularFunction3',5'-cyclic-AMP phosphodiesterase activity

PDE4B PDE4C PDE4D

7.75e-0522763GO:0004115
GeneOntologyMolecularFunctionG protein-coupled serotonin receptor activity

HTR2A CHRM2 CHRM3

7.75e-0522763GO:0004993
GeneOntologyMolecularFunction3',5'-cyclic-GMP phosphodiesterase activity

PDE4B PDE4C PDE4D

1.01e-0424763GO:0047555
GeneOntologyMolecularFunction3',5'-cyclic-nucleotide phosphodiesterase activity

PDE4B PDE4C PDE4D

1.15e-0425763GO:0004114
GeneOntologyMolecularFunctioncyclic-nucleotide phosphodiesterase activity

PDE4B PDE4C PDE4D

1.45e-0427763GO:0004112
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

GRIK4 GRIN2C CHRM2 CHRM3

1.92e-0475764GO:0098960
GeneOntologyMolecularFunctionnucleocytoplasmic carrier activity

IPO5 CSE1L XPO4

2.43e-0432763GO:0140142
GeneOntologyMolecularFunctionG protein-coupled acetylcholine receptor activity

CHRM2 CHRM3

2.97e-047762GO:0016907
GeneOntologyMolecularFunctionG protein-coupled amine receptor activity

HTR2A CHRM2 CHRM3

5.09e-0441763GO:0008227
GeneOntologyMolecularFunctionphosphoric diester hydrolase activity

PDE4B PDE4C PDE4D CHRM3

5.14e-0497764GO:0008081
GeneOntologyMolecularFunctionpyrimidine nucleotide-sugar transmembrane transporter activity

SLC35B4 SLC35A1

7.69e-0411762GO:0015165
GeneOntologyMolecularFunctionnuclear export signal receptor activity

CSE1L XPO4

9.21e-0412762GO:0005049
GeneOntologyMolecularFunctionarrestin family protein binding

CHRM2 FFAR4

9.21e-0412762GO:1990763
GeneOntologyMolecularFunctionG protein-coupled neurotransmitter receptor activity

CHRM2 CHRM3

1.09e-0313762GO:0099528
GeneOntologyMolecularFunctionnucleotide-sugar transmembrane transporter activity

SLC35B4 SLC35A1

1.26e-0314762GO:0005338
GeneOntologyMolecularFunctionglutamate-gated receptor activity

GRIK4 GRIN2C

1.87e-0317762GO:0004970
GeneOntologyMolecularFunctionacetylcholine receptor activity

CHRM2 CHRM3

3.43e-0323762GO:0015464
GeneOntologyBiologicalProcesscAMP catabolic process

PDE4B PDE4C PDE4D

3.10e-069703GO:0006198
GeneOntologyBiologicalProcesssmooth muscle contraction

PDE4B PDE4D HTR2A PIK3C2A CHRM2 CHRM3

6.00e-06133706GO:0006939
GeneOntologyBiologicalProcessnegative regulation of relaxation of cardiac muscle

PDE4B PDE4D

1.14e-052702GO:1901898
GeneOntologyBiologicalProcesscyclic nucleotide catabolic process

PDE4B PDE4C PDE4D

1.33e-0514703GO:0009214
GeneOntologyBiologicalProcessG protein-coupled serotonin receptor signaling pathway

HTR2A CHRM2 CHRM3

6.31e-0523703GO:0098664
GeneOntologyBiologicalProcesscAMP metabolic process

PDE4B PDE4C PDE4D

8.16e-0525703GO:0046058
GeneOntologyBiologicalProcessphospholipase C-activating G protein-coupled receptor signaling pathway

HTR2A CHRM2 CHRM3 CX3CR1 FFAR4

8.94e-05133705GO:0007200
GeneOntologyBiologicalProcessvascular associated smooth muscle contraction

HTR2A PIK3C2A CHRM3

1.57e-0431703GO:0014829
DomainPDEase

PDE4B PDE4C PDE4D

5.99e-0519763IPR023088
DomainARM-type_fold

IPO5 CSE1L UPF2 PIK3C2A HEATR4 PKP1 XPO4 LRBA

6.99e-05339768IPR016024
DomainPDEase_I

PDE4B PDE4C PDE4D

8.17e-0521763PF00233
DomainPDEASE_I

PDE4B PDE4C PDE4D

8.17e-0521763PS00126
DomainPDEase_CS

PDE4B PDE4C PDE4D

8.17e-0521763IPR023174
Domain-

PDE4B PDE4C PDE4D

9.43e-05227631.10.1300.10
DomainPDEase_catalytic_dom

PDE4B PDE4C PDE4D

1.08e-0423763IPR002073
DomainHDc

PDE4B PDE4C PDE4D

1.23e-0424763SM00471
DomainHD/PDEase_dom

PDE4B PDE4C PDE4D

1.23e-0424763IPR003607
DomainMusac_Ach_rcpt

CHRM2 CHRM3

1.62e-045762IPR000995
Domain-

CACNA2D2 ITIH6 ITGB7 ITIH1

2.35e-04747643.40.50.410
DomainITI_HC_C

ITIH6 ITIH1

2.43e-046762IPR010600
DomainITI_HC_C

ITIH6 ITIH1

2.43e-046762PF06668
Domain-

IPO5 CSE1L HEATR4 PKP1 XPO4 LRBA

2.88e-042227661.25.10.10
DomainVWFA

CACNA2D2 ITIH6 ITGB7 ITIH1

3.48e-0482764PS50234
DomainVWA

CACNA2D2 ITIH6 ITGB7 ITIH1

3.82e-0484764SM00327
DomainVIT

ITIH6 ITIH1

4.50e-048762PF08487
DomainVIT

ITIH6 ITIH1

4.50e-048762SM00609
DomainVWF_A

CACNA2D2 ITIH6 ITGB7 ITIH1

7.11e-0499764IPR002035
DomainVIT

ITIH6 ITIH1

7.20e-0410762PS51468
DomainVIT

ITIH6 ITIH1

7.20e-0410762IPR013694
DomainARM-like

IPO5 CSE1L HEATR4 PKP1 XPO4 LRBA

8.10e-04270766IPR011989
DomainIMPORTIN_B_NT

IPO5 CSE1L

1.44e-0314762PS50166
DomainVWA

CACNA2D2 ITIH6 ITIH1

1.54e-0356763PF00092
DomainImportin-beta_N

IPO5 CSE1L

2.14e-0317762IPR001494
DomainIontro_rcpt

GRIK4 GRIN2C

2.40e-0318762IPR001320
DomainLig_chan-Glu_bd

GRIK4 GRIN2C

2.40e-0318762PF10613
DomainIono_rcpt_met

GRIK4 GRIN2C

2.40e-0318762IPR001508
DomainGlu/Gly-bd

GRIK4 GRIN2C

2.40e-0318762IPR019594
DomainLig_chan-Glu_bd

GRIK4 GRIN2C

2.40e-0318762SM00918
DomainLig_chan

GRIK4 GRIN2C

2.40e-0318762PF00060
DomainPBPe

GRIK4 GRIN2C

2.40e-0318762SM00079
DomaintRNA-bd_arm

SOX6 KIF20B

4.26e-0324762IPR010978
DomainTIR

TICAM1 TLR7

4.26e-0324762PS50104
DomainTIR_dom

TICAM1 TLR7

4.61e-0325762IPR000157
DomainGPCR_Rhodpsn_7TM

HTR2A GPR37 GPR85 OR1G1 CHRM2 CHRM3 CX3CR1 FFAR4

5.80e-03670768IPR017452
Domain7tm_1

HTR2A GPR37 GPR85 OR1G1 CHRM2 CHRM3 CX3CR1 FFAR4

6.16e-03677768PF00001
DomainG_PROTEIN_RECEP_F1_1

HTR2A GPR37 GPR85 OR1G1 CHRM2 CHRM3 CX3CR1 FFAR4

6.60e-03685768PS00237
DomainG_PROTEIN_RECEP_F1_2

HTR2A GPR37 GPR85 OR1G1 CHRM2 CHRM3 CX3CR1 FFAR4

6.95e-03691768PS50262
DomainGPCR_Rhodpsn

HTR2A GPR37 GPR85 OR1G1 CHRM2 CHRM3 CX3CR1 FFAR4

7.00e-03692768IPR000276
DomainLRRCT

LRRN3 TLR7

7.49e-0332762PF01463
PathwayREACTOME_DARPP_32_EVENTS

PDE4B PDE4C PDE4D

3.04e-0516553MM14699
PathwayWP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION

PDE4B PDE4C PDE4D GRIN2C

6.10e-0555554M39763
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

HTR2A GPR37 GPR85 OR1G1 CHRM2 CHRM3 CX3CR1

6.38e-05260557M39397
PathwayWP_SILDENAFIL_TREATMENT

PDE4B PDE4C PDE4D

9.42e-0523553M46455
PathwayREACTOME_DARPP_32_EVENTS

PDE4B PDE4C PDE4D

1.07e-0424553M751
PathwayREACTOME_MUSCARINIC_ACETYLCHOLINE_RECEPTORS

CHRM2 CHRM3

1.48e-045552M27300
PathwayREACTOME_MUSCARINIC_ACETYLCHOLINE_RECEPTORS

CHRM2 CHRM3

1.48e-045552MM15006
PathwayWP_MONOAMINE_GPCRS

HTR2A CHRM2 CHRM3

2.82e-0433553M39585
PathwayWP_GPCRS_OTHER

HTR2A OR1G1 CHRM2 CHRM3

4.68e-0493554M39629
PathwayREACTOME_TRANSPORT_OF_NUCLEOTIDE_SUGARS

SLC35B4 SLC35A1

5.29e-049552M27688
PathwayREACTOME_TRANSPORT_OF_NUCLEOTIDE_SUGARS

SLC35B4 SLC35A1

5.29e-049552MM15421
PathwayREACTOME_AMINE_LIGAND_BINDING_RECEPTORS

HTR2A CHRM2 CHRM3

5.79e-0442553M5868
PathwayREACTOME_AMINE_LIGAND_BINDING_RECEPTORS

HTR2A CHRM2 CHRM3

5.79e-0442553MM14971
PathwayREACTOME_SIGNALING_BY_GPCR

PDE4B PDE4C PDE4D HTR2A GPR37 CHRM2 CHRM3 CX3CR1 FFAR4

8.09e-04646559MM14962
PathwayREACTOME_G_ALPHA_I_SIGNALLING_EVENTS

PDE4B PDE4C PDE4D GPR37 CHRM2 CX3CR1

8.79e-04289556MM15057
Pubmed

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.

PDE4B PDE4C PDE4D

4.17e-0847739371714
Pubmed

Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine.

PDE4B PDE4C PDE4D

4.17e-08477324732776
Pubmed

Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice.

PDE4B PDE4C PDE4D

4.17e-08477334943270
Pubmed

PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.

PDE4B PDE4C PDE4D

4.17e-08477332738081
Pubmed

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

PDE4B PDE4C PDE4D

4.17e-0847738413254
Pubmed

Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.

PDE4B PDE4C PDE4D

4.17e-08477322946044
Pubmed

Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.

PDE4B PDE4C PDE4D

4.17e-08477333609559
Pubmed

The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.

PDE4B PDE4C PDE4D

1.04e-07577333944911
Pubmed

A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons.

PDE4B PDE4C PDE4D

1.04e-0757738586960
Pubmed

Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum.

PDE4B PDE4C PDE4D

2.08e-07677318923023
Pubmed

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.

IPO5 FASN CSE1L KRT17 ZUP1

1.26e-068477529563501
Pubmed

Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury.

TICAM1 TLR7 CX3CR1

1.70e-061177323843525
Pubmed

Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.

PDE4B PDE4C PDE4D

2.94e-06137738009369
Pubmed

Roles of M2 and M3 muscarinic receptors in the generation of rhythmic motor activity in mouse small intestine.

CHRM2 CHRM3

4.84e-06277223889852
Pubmed

Effects of PDE4 gene polymorphisms on efficacy and adverse drug events of ritodrine therapy in preterm labor patients: a prospective observational study.

PDE4B PDE4D

4.84e-06277231324945
Pubmed

Overexpression of phosphodiesterase-4 subtypes involved in surgery-induced neuroinflammation and cognitive dysfunction in mice.

PDE4B PDE4D

4.84e-06277228235598
Pubmed

Muscarinic suppression of ATP-sensitive K+ channels mediated by the M3/Gq/11/phospholipase C pathway contributes to mouse ileal smooth muscle contractions.

CHRM2 CHRM3

4.84e-06277230001145
Pubmed

[Protective effects of HRD1 and 4-phenylbutyric acid against neuronal cell death].

GPR37 SYVN1

4.84e-06277215572843
Pubmed

M2 muscarinic receptors induce airway smooth muscle activation via a dual, Gbetagamma-mediated inhibition of large conductance Ca2+-activated K+ channel activity.

CHRM2 CHRM3

4.84e-06277218524769
Pubmed

Histological determination of the areas enriched in cholinergic terminals and M2 and M3 muscarinic receptors in the mouse central auditory system.

CHRM2 CHRM3

4.84e-06277220665816
Pubmed

Novel functions of ubiquitin ligase HRD1 with transmembrane and proline-rich domains.

GPR37 SYVN1

4.84e-06277218344614
Pubmed

Roles of M2 and M3 muscarinic receptors in cholinergic nerve-induced contractions in mouse ileum studied with receptor knockout mice.

CHRM2 CHRM3

4.84e-06277217099717
Pubmed

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain.

GPR37 CX3CR1

4.84e-06277230010619
Pubmed

Gastric body cholinergic contractile signal transduction in M2 and M3 receptor knockout mice.

CHRM2 CHRM3

4.84e-06277223786223
Pubmed

Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.

PDE4B PDE4D

4.84e-06277215003452
Pubmed

Retinal Microglial Activation Following Topical Application of Intracellular Toll-Like Receptor Ligands.

TLR7 CX3CR1

4.84e-06277226574796
Pubmed

CX3CR1 mediates motor dysfunction in mice through 5-HTR2a.

HTR2A CX3CR1

4.84e-06277238145872
Pubmed

[Acetylcholine induces human detrusor muscle cell proliferation: molecular and pharmacological characterization].

CHRM2 CHRM3

4.84e-06277222610841
Pubmed

PDE4D plays a critical role in the control of airway smooth muscle contraction.

PDE4B PDE4D

4.84e-06277214519662
Pubmed

Mice lacking M2 and M3 muscarinic acetylcholine receptors are devoid of cholinergic smooth muscle contractions but still viable.

CHRM2 CHRM3

4.84e-06277212486155
Pubmed

Functions of Muscarinic Receptor Subtypes in Gastrointestinal Smooth Muscle: A Review of Studies with Receptor-Knockout Mice.

CHRM2 CHRM3

4.84e-06277233477687
Pubmed

Muscarinic receptor-mediated bronchoconstriction is coupled to caveolae in murine airways.

CHRM2 CHRM3

4.84e-06277220023174
Pubmed

Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B).

PDE4B PDE4D

4.84e-06277217700644
Pubmed

Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors.

CHRM2 CHRM3

4.84e-06277214977875
Pubmed

Comparison of the pharmacological antagonism of M2 and M3 muscarinic receptors expressed in isolation and in combination.

CHRM2 CHRM3

4.84e-06277212694864
Pubmed

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.

PDE4B PDE4D

4.84e-06277217088426
Pubmed

Muscarinic receptor expression increases following exposure to intravesical pressures of < or =40 cm-H2O: a possible mechanism for pressure-induced cell proliferation.

CHRM2 CHRM3

4.84e-06277218563417
Pubmed

Muscarinic (M) receptors in coronary circulation: gene-targeted mice define the role of M2 and M3 receptors in response to acetylcholine.

CHRM2 CHRM3

4.84e-06277215130910
Pubmed

PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts.

PDE4B PDE4D

4.84e-06277221288894
Pubmed

Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.

PDE4B PDE4C

4.84e-06277217727341
Pubmed

Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.

PDE4B PDE4D

4.84e-06277229123207
Pubmed

Mutation screening of the muscarinic m2 and m3 receptor genes in asthmatics, outgrow subjects, and normal controls.

CHRM2 CHRM3

4.84e-06277212381439
Pubmed

Further characterization of the synergistic activation mechanism of cationic channels by M2 and M3 muscarinic receptors in mouse intestinal smooth muscle cells.

CHRM2 CHRM3

4.84e-06277231875697
Pubmed

A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.

GPR37 SYVN1

4.84e-06277217059562
Pubmed

The proto-oncogene SET interacts with muscarinic receptors and attenuates receptor signaling.

CHRM2 CHRM3

1.45e-05377217065150
Pubmed

Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria.

ITGB7 CX3CR1

1.45e-05377221333554
Pubmed

Three distinct muscarinic signalling pathways for cationic channel activation in mouse gut smooth muscle cells.

CHRM2 CHRM3

1.45e-05377217463038
Pubmed

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner.

SALL1 CX3CR1

1.45e-05377229275859
Pubmed

Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity.

CHRM2 CHRM3

1.45e-05377212713643
Pubmed

Role of muscarinic receptor subtypes in the constriction of peripheral airways: studies on receptor-deficient mice.

CHRM2 CHRM3

1.45e-05377214645675
Pubmed

Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.

PDE4B PDE4D

1.45e-05377215585880
Pubmed

Identifying the variables that drive tamoxifen-independent CreERT2 recombination: Implications for microglial fate mapping and gene deletions.

SALL1 CX3CR1

1.45e-05377231785096
Pubmed

Muscarinic receptor knockout mice: role of muscarinic acetylcholine receptors M(2), M(3), and M(4) in carbamylcholine-induced gallbladder contractility.

CHRM2 CHRM3

1.45e-05377211961069
Pubmed

Localization of muscarinic receptors M1R, M2R and M3R in the human colon.

CHRM2 CHRM3

1.45e-05377220146726
Pubmed

CHRM2 but not CHRM1 or CHRM3 polymorphisms are associated with asthma susceptibility in Mexican patients.

CHRM2 CHRM3

1.45e-05377224430298
Pubmed

Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury.

SALL1 CX3CR1

1.45e-05377232284604
Pubmed

Urinary Retention, Incontinence, and Dysregulation of Muscarinic Receptors in Male Mice Lacking Mras.

CHRM2 CHRM3

1.45e-05377226516777
Pubmed

Muscarinic M₃ receptors contribute to allergen-induced airway remodeling in mice.

CHRM2 CHRM3

1.45e-05377224156289
Pubmed

Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment.

HTR2A GRIK4

1.45e-05377219924111
Pubmed

Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect.

PDE4B PDE4D

1.45e-05377210213096
Pubmed

The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).

PDE4B PDE4D

1.45e-05377224555506
Pubmed

M2 and M3 muscarinic receptors are involved in enteric nerve-mediated contraction of the mouse ileum: Findings obtained with muscarinic-receptor knockout mouse.

CHRM2 CHRM3

1.45e-05377217008557
Pubmed

Cholinergic agonist-induced pepsinogen secretion from murine gastric chief cells is mediated by M1 and M3 muscarinic receptors.

CHRM2 CHRM3

1.45e-05377215933222
Pubmed

Proliferative actions of muscarinic receptors expressed in macrophages derived from normal and tumor bearing mice.

CHRM2 CHRM3

1.45e-05377218078830
Pubmed

SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity.

SALL1 CX3CR1

1.45e-05377237322178
Pubmed

Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.

PDE4B PDE4D

1.45e-05377218508768
Pubmed

Association of the Cholinergic Muscarinic M2 Receptor with Autonomic Nervous System Activity in Patients with Schizophrenia on High-Dose Antipsychotics.

CHRM2 CHRM3

1.45e-05377227923235
Pubmed

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.

PDE4B PDE4D

1.45e-05377217404263
Pubmed

Dual microglia effects on blood brain barrier permeability induced by systemic inflammation.

SALL1 CX3CR1

1.45e-05377231862977
Pubmed

Expression and distribution of cholinergic receptors in the human urothelium.

CHRM2 CHRM3

1.45e-05377217335853
Pubmed

Paradoxical sleep in mice lacking M3 and M2/M4 muscarinic receptors.

CHRM2 CHRM3

1.45e-05377216110248
Pubmed

Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.

PDE4B PDE4D

1.45e-05377216034090
Pubmed

Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene.

CHRM2 CHRM3

1.45e-0537722848036
Pubmed

Control of glycinergic input to spinal dorsal horn neurons by distinct muscarinic receptor subtypes revealed using knockout mice.

CHRM2 CHRM3

1.45e-05377217878406
Pubmed

Quantitative analysis of muscarinic acetylcholine receptor homo- and heterodimerization in live cells: regulation of receptor down-regulation by heterodimerization.

CHRM2 CHRM3

1.45e-05377216368694
Pubmed

M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes.

CHRM2 CHRM3

1.45e-05377217192665
Pubmed

Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice.

CHRM2 CHRM3

1.45e-05377223397297
Pubmed

M(2) and M(3) muscarinic receptor-mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice.

CHRM2 CHRM3

1.45e-05377215965495
Pubmed

Distinct mixtures of muscarinic receptor subtypes mediate inhibition of noradrenaline release in different mouse peripheral tissues, as studied with receptor knockout mice.

CHRM2 CHRM3

1.45e-05377215965496
Pubmed

Overview of PDEs and their regulation.

PDE4B PDE4C PDE4D

2.32e-052577317307970
Pubmed

Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice.

TICAM1 TLR7

2.89e-05477228724768
Pubmed

Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation.

SALL1 CX3CR1

2.89e-05477236228615
Pubmed

MAdCAM-1/α4β7 Integrin-Mediated Lymphocyte/Endothelium Interactions Exacerbate Acute Immune-Mediated Hepatitis in Mice.

ITGB7 CX3CR1

2.89e-05477233316453
Pubmed

Extracellular MicroRNAs Induce Potent Innate Immune Responses via TLR7/MyD88-Dependent Mechanisms.

TICAM1 TLR7

2.89e-05477228768728
Pubmed

Muscarinic receptor subtypes. Physiology and clinical implications.

CHRM2 CHRM3

2.89e-0547722674717
Pubmed

Differential regulation of mTOR-dependent S6 phosphorylation by muscarinic acetylcholine receptor subtypes.

CHRM2 CHRM3

2.89e-05477218348264
Pubmed

Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes.

CHRM2 CHRM3

2.89e-0547722739737
Pubmed

Ligation of Toll-like receptor 3 differentially regulates M2 and M3 muscarinic receptor expression and function in human airway smooth muscle cells.

CHRM2 CHRM3

2.89e-05477217851256
Pubmed

Donor pulmonary intravascular nonclassical monocytes recruit recipient neutrophils and mediate primary lung allograft dysfunction.

TICAM1 CX3CR1

2.89e-05477228615357
Pubmed

Muscarinic acetylcholine receptors activate expression of the EGR gene family of transcription factors.

CHRM2 CHRM3

2.89e-0547729603968
Pubmed

Identification of a family of muscarinic acetylcholine receptor genes.

CHRM2 CHRM3

2.89e-0547723037705
Pubmed

Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling.

CHRM2 CHRM3

2.89e-05477215147302
Pubmed

Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.

PDE4B PDE4D

2.89e-05477221670503
Pubmed

Comparative analysis of CreER transgenic mice for the study of brain macrophages: A case study.

SALL1 CX3CR1

2.89e-05477231762013
Pubmed

Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.

PDE4B PDE4D

2.89e-05477215644445
Pubmed

Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via Toll-like receptor 7 signaling.

TICAM1 TLR7

2.89e-05477226363072
Pubmed

Muscarinic acetylcholine receptors in the mouse esophagus: focus on intraganglionic laminar endings (IGLEs).

CHRM2 CHRM3

2.89e-05477223742744
Pubmed

Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C.

CHRM2 CHRM3

2.89e-0547728576254
Pubmed

β1/2 or M2/3 Receptors Are Required for Different Gastrointestinal Motility Responses Induced by Acupuncture at Heterotopic or Homotopic Acupoints.

CHRM2 CHRM3

2.89e-05477227978539
Pubmed

Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia.

PDE4B PDE4D

2.89e-05477211839681
Cytoband3p21.3

CACNA2D2 SLC38A3 CX3CR1

1.38e-04597733p21.3
Cytoband7q31

GPR37 GPR85

9.48e-04277727q31
CytobandEnsembl 112 genes in cytogenetic band chr7q31

LRRN3 GPR37 GPR85

1.72e-03140773chr7q31
Cytoband17q25

FASN GRIN2C

1.98e-033977217q25
CytobandEnsembl 112 genes in cytogenetic band chr3p21

CACNA2D2 SLC38A3 ITIH1 DNAH1

2.01e-03316774chr3p21
Cytoband3p21.1

ITIH1 DNAH1

2.29e-03427723p21.1
GeneFamilyPhosphodiesterases

PDE4B PDE4C PDE4D

6.36e-0524593681
GeneFamilyCholinergic receptors muscarinic

CHRM2 CHRM3

1.04e-045592180
GeneFamilyExportins

CSE1L XPO4

2.18e-047592547
CoexpressionGSE17721_PAM3CSK4_VS_CPG_12H_BMDC_UP

SLC12A6 CSE1L GPR85 SEC31A LRBA CX3CR1 BBLN

2.08e-06200777M3867
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC12A6 LRRN3 PDE4C AFF1 SYVN1 FAM43A

1.09e-06194776ad1aacff97beb76f4211942676e1d5e84087d44e
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC12A6 LRRN3 PDE4C AFF1 SYVN1 FAM43A

1.09e-06194776fdd59b1e036b2d6d8877e1a920a0e56a91a2a882
ToppCellMyeloid-Myeloid-C_(Cd16+_Monocyte)|Myeloid / shred on cell class and cell subclass (v4)

SLC12A6 GPR37 TLR7 CX3CR1 FAM43A

1.86e-06117775d1936e76a935216783a73ab414e4147fa48e68eb
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IPO5 CACNA2D2 GATA5 CHRM2 COL1A2

1.18e-0517177582de2885c8ce4fb7776da6a0207b3355c0910121
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IPO5 CACNA2D2 GATA5 CHRM2 COL1A2

1.18e-0517177509e653973962fb884878089d281f0947f7a285f6
ToppCellBronchial_Biopsy-Epithelial-Ionocytes|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

SALL1 CACNA2D2 CELF3 CHRM2 FAM43A

1.29e-051747757e7b13de916cd4fa0fa6fb06e6b4942877afa9fb
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GLT8D2 ANK1 CACNA2D2 GPR37 CHRM2

1.36e-051767754ed73c73972334f6dc4229920205547823252fa0
ToppCellfacs-Heart-RA-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK1 CACNA2D2 GRIN2C CHRM2 SLC38A3

1.92e-05189775e758b264c0a47127e33e66c395cf5a3224c7305b
ToppCellfacs-Heart-RA-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK1 CACNA2D2 GRIN2C CHRM2 SLC38A3

1.92e-05189775b98f60875b1a12b2ec9dc91889298ae57f98602f
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC12A6 LRRN3 AFF1 SYVN1 FAM43A

2.17e-0519477511709704079f24a730476572dc2f01e9d2226e2c
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC12A6 LRRN3 AFF1 SYVN1 FAM43A

2.17e-051947753a1f95639d5f239f001bd67d4213e8938e7f299d
ToppCellP28-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

GLT8D2 PDE4B GRIK4 GATA5 COL1A2

2.17e-051947753c661c6768c3f05d2aba03d329adb257ca201b2d
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KRT17 PKP1 CHST9 KIF20B BBLN

2.23e-051957755812b1615676f3b77eb4769216b98b360c417c0d
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX6 GLT8D2 SALL1 FAM43A COL1A2

2.40e-051987754a4566f86c9365a41b4cfd1609eac09bd73b3f34
ToppCelldistal-2-mesenchymal-Myofibroblast|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GLT8D2 HTR2A MTTP GATA5 COL1A2

2.46e-05199775b8f3cf5bcfde1066bdb49b14fdc842fe9692a6b7
ToppCelldistal-2-mesenchymal-Alveolar_Fibroblast|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GLT8D2 LRRN3 GRIK4 GATA5 COL1A2

2.52e-0520077512b705dabec1b3752a488a891eda1a5123fcdc41
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Sema3e_Kank4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SOX6 ANK1 CACNA2D2 FAM43A

5.25e-05118774d7dcffc0476a6e471debd83904a6569c6f27a594
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SOX6 ANK1 CACNA2D2 FFAR4

6.77e-0512677484dce108561d4b745d19250c2ac0667d9e4ea17d
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gpr149_Islr|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SOX6 ANK1 CACNA2D2 CHRM2

6.77e-051267743539a8fdbb52d191f36dce68c38798ad4d2b491a
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gabrg1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SOX6 CACNA2D2 CHRM2 FFAR4

1.02e-041407742c44e8cc5190226049be7ebc465d685393e701c4
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Itm2a|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SOX6 ANK1 CACNA2D2 FAM43A

1.14e-041447740bbe670454846cf9bc7464ae4e91488415c4111d
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SOX6 ANK1 CACNA2D2 CHRM2

1.17e-041457748b13b576fd2e6e33ccb146860a91a53cee0cdd4d
ToppCelldroplet-Liver-Hepatocytes-24m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC15A5 CHRM3 SLC38A3 ITIH1

1.40e-04152774c21e2152b0130485659051d8fb7fb4589d1ec997
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)-|343B / Donor, Lineage, Cell class and subclass (all cells)

ARHGAP40 KRT17 PKP1 CHST9

1.58e-04157774dd08dc19d434e94a194076c462ee273c682abf55
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)|343B / Donor, Lineage, Cell class and subclass (all cells)

ARHGAP40 KRT17 PKP1 CHST9

1.58e-0415777470fd6c46db4250c7de5c4686a9500689402737f6
ToppCell18-Distal-Epithelial-Basal_cell|Distal / Age, Tissue, Lineage and Cell class

SOX6 KRT17 PKP1 CHST9

1.62e-04158774183f445967e09e871c93d8e94781ed9fec894169
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE4B MTTP ZUP1 FAM43A

1.62e-041587741d78578dc1f8ba43dacdccae1082c0b9d749f64d
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gpr149_Islr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SOX6 ANK1 CACNA2D2 CHRM2

1.66e-04159774c64fff8d89f84d1f5a0cc432e31f56f741162505
ToppCellPaneth_cell|World / shred on cell type and cluster

CACNA2D2 PKP1 CHRM2 CX3CR1

1.70e-04160774d787b7cdb8c3f677ac9c4934a5df9cc194df3987
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)-|390C / Donor, Lineage, Cell class and subclass (all cells)

KRT17 CDKL3 PKP1 CHST9

1.70e-0416077418ae6822915d16699beb9047baeef9b006901a35
ToppCellC_07|World / shred on cell type and cluster

CACNA2D2 PKP1 CHRM2 CX3CR1

1.70e-04160774b7c5a8a1c85da92e1945721b6887b32fad7b76b8
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FASN MTTP SLC38A3 ITIH1

1.70e-04160774c42bcc6c7d113f0db43febb088b75ca4ac7cb7a3
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)|390C / Donor, Lineage, Cell class and subclass (all cells)

KRT17 CDKL3 PKP1 CHST9

1.70e-04160774830f17bad94de05612fe6d53d39e42a4b3f3e2f3
ToppCellfacs-Lung-Endomucin-24m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FASN KRT17 CHRM2 KIF20B

1.79e-04162774497ae9f86a5e7946d0fde932b35719a382a6b691
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC12A6 FAM111A CX3CR1 FFAR4

1.79e-0416277493bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCellfacs-Lung-Endomucin-24m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FASN KRT17 CHRM2 KIF20B

1.79e-041627747b2949eba2b4aea239d96ed82aafab13b07624eb
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SOX6 ANK1 CACNA2D2 FAM43A

1.83e-04163774db6b7ce6f7221bb73c5e650ac51cdd5d7ef00675
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Tpbg|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SOX6 ANK1 CACNA2D2 FAM43A

1.87e-04164774f0499e6c1b17c4df72b18b294e3b53ef723da2ac
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Tac1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SOX6 ANK1 CACNA2D2 FAM43A

1.92e-04165774d8df50f5a3b646e8ea13739fdc65ce6f39b4d4d2
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FASN MTTP SLC38A3 ITIH1

1.92e-04165774d449a568664a81d9b5538e8f409301448a32ac37
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Tpbg|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SOX6 ANK1 CACNA2D2 FAM43A

1.96e-04166774b4241f8d2a0aa910dbb0d0d5d3631a9b73453fe9
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L6_LHX6_GLP1R|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX6 ANK1 CACNA2D2 CHRM2

2.05e-041687742eed7dc1a2aff11be024823c4323c42bc94362f6
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FASN MTTP SLC38A3 ITIH1

2.05e-04168774b98af4043dfa5dfa4413e482879fad88de484675
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SOX6 ANK1 CACNA2D2 FAM43A

2.05e-041687742572a3dd4f3f619bd26a3cd6e60de43821d8bb64
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FASN MTTP SLC38A3 ITIH1

2.05e-04168774073b53d4cee6bc8c5c6fce51cf6cd9c316478f69
ToppCelldroplet-Liver-HEPATOCYTES|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FASN MTTP SLC38A3 ITIH1

2.10e-04169774f195467438c589f87224bde7da720dea072d110c
ToppCelldroplet-Marrow-BM-30m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX6 ANK1 FUT1 CX3CR1

2.10e-041697748e7a30eb546fc6fa184ebb76f54b74b278005a84
ToppCelldroplet-Liver-HEPATOCYTES-1m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FASN MTTP SLC38A3 ITIH1

2.10e-041697747785cab967a33560830c394c918d6ce625103858
ToppCellileum|World / shred on tissue and cell subclass

SOX6 MYO1A MTTP EPS8L3

2.15e-041707749f1211bd4287620e19a59f21e6ecdca3e42e0260
ToppCellmild_COVID-19_(asymptomatic)-RBC|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

CSE1L ANK1 CACNA2D2 EDRF1

2.20e-0417177478491478ba65bad45238fe114f5251b2adea323d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE4B MYO1A TLR7 CX3CR1

2.25e-04172774f6b4754a7e4b3e38030316a0ae00d932bfa87e41
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR FAM111A TLR7 CX3CR1

2.30e-04173774869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TICAM1 TLR7 KIF20B CX3CR1

2.30e-0417377412c6875f881cb0fbff09d753b53c1cce7a95527f
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR FAM111A TLR7 CX3CR1

2.30e-041737740672bd8a4a9d18af343d01f09253fb3388896c10
ToppCellfacs-Brain_Myeloid-Cerebellum-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR FAM111A TLR7 CX3CR1

2.30e-04173774870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KRT17 SLC15A5 CHRM2 ANGPTL5

2.35e-04174774912a9e892b29d945666fc37c986009c97c668ac8
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KRT17 GPR37 SLC15A5 ANGPTL5

2.35e-04174774e0de0a14319be1a115e5be05d6f9b562e7b32c4a
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FASN MTTP SLC38A3 ITIH1

2.40e-041757745c38d4b6c03473d841e6203a7efaa6dcb2d59386
ToppCellBronchial_Biopsy-Epithelial-Ionocytes|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

SALL1 CACNA2D2 CHRM2 FAM43A

2.40e-0417577413b8f7dc38c90b74d4a20a84a8705d8e2ec244f6
ToppCell5'-Adult-Distal_Rectal-Epithelial-goblet-BEST2+_Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FASN CACNA2D2 CELF3 FFAR4

2.40e-04175774019ea30ac55748463d7917abf3d3f0e804189bfd
ToppCellwk_08-11-Epithelial-Proximal_epithelial-SMG_basal_2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

KRT17 TICAM1 PKP1 CHST9

2.40e-041757744462000b22af227555413ba202a872868eecde6c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L6_LHX6_GLP1R|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX6 ANK1 CACNA2D2 CHRM2

2.50e-041777742b675840b7d2bb536c2c600936733bd9e97e7120
ToppCelldroplet-Liver-LIVER-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE4B ITGB7 CX3CR1 FFAR4

2.50e-0417777412f804438add5e016b65f066e8363921ba28f919
ToppCellwk_15-18-Mesenchymal-Chondrocyte-Resting_chondrocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SOX6 GLT8D2 ITIH6 SLC38A3

2.50e-04177774b01d7a6a78169962123ddfb0bb588f51d138ad02
ToppCelldroplet-Liver-LIVER-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE4B ITGB7 CX3CR1 FFAR4

2.50e-041777743b6b6a6a13458c5ffb8df8873372efad9fda6eee
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-5|TCGA-Skin / Sample_Type by Project: Shred V9

LIFR GLT8D2 GRIK4 CHRM3

2.56e-04178774ad5cd505ca1cef8ac29b2af7e2c3e01ebc140c14
ToppCell5'-Adult-Distal_Rectal-Epithelial-goblet|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FASN CACNA2D2 CELF3 FFAR4

2.56e-041787749099b47e0756d6a1b7ba1c6aa7b47c5425f649e0
ToppCellfacs-Marrow-B-cells-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SALL1 GPR37 SLC38A3 CX3CR1

2.67e-04180774c54af6fb11484dacd3efa1f10a487376ff820a5e
ToppCell3'_v3-bone_marrow-Hematopoietic_Erythro-Mega-Erythrocytic-Meg|bone_marrow / Manually curated celltypes from each tissue

HTR2A GATA5 FUT1 CHRM2

2.67e-0418077444ba37bead1ac39bce4d3eef00961063c50ced0d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SALL1 ANK1 CARMIL3 GRIK4

2.67e-04180774b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCellfacs-Marrow-B-cells-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SALL1 GPR37 SLC38A3 CX3CR1

2.67e-0418077407ac979b21be2425294d9818c48b5a1e6f014c19
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX6 ANK1 CACNA2D2 CHRM2

2.73e-04181774af92b8b7f455210dab502ef6964f3a0162180759
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PDE4D HTR2A XPO4 KIF20B

2.73e-04181774986c036e656f24fe374807e2711cec9e3c83c892
ToppCellfacs-Kidney-nan-3m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR KRT17 GPR37 CX3CR1

2.78e-041827744c5d14e33ebdf117b5aa9e2f57aaa89aa51f72bf
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX6 ANK1 CACNA2D2 CHRM2

2.84e-04183774121791ef84e7ce377ed6f5b7953af8865e04958e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX6 ANK1 CACNA2D2 GATA5

2.84e-04183774d2074b13b4831ec18c81273d9a1ff673c3f6a16d
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

LIFR PDE4D CACNA2D2 ZSWIM5

2.84e-041837746847c1252d6bb105524f812658112517fd351eab
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Proximal_secretory_progenitors|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SALL1 KRT17 MYO1A CHST9

2.90e-04184774fcb5dd4fb3fa79f3b6029fad32a474cacde35a3b
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-chondrocyte|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

GLT8D2 ITIH6 ANGPTL5 SLC38A3

3.02e-0418677480a0a42ca8585cdb1dda57a18c254316a126ee64
ToppCellfacs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK1 GRIN2C CHRM2 SLC38A3

3.02e-04186774337f768cc43db2db96ba6495b076006b1a5b0331
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT17 CEP250 CLUH COL1A2

3.02e-0418677415ab6666748a641226e42e6ca6eeaf186a501c95
ToppCellfacs-Heart-LA-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK1 GRIN2C CHRM2 SLC38A3

3.02e-04186774e378c82ef6d6cb24751515aa499a01372b3e7ccf
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

HTR2A GPR85 CHRM2 COL1A2

3.02e-041867748915436d09775f2828a7678af203b1082b36e21c
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT17 CEP250 CLUH COL1A2

3.02e-041867744ed1b97e2552f3c4134f25665d7513498ffac16c
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX6 GLT8D2 SALL1 COL1A2

3.02e-04186774360c3e9e5c3a943e68e6939b4a47821bfc75b553
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX6 ANK1 CACNA2D2 CHRM2

3.09e-04187774d413fb4b1531b297af5012a392b88128510c2de8
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SOX6 ANK1 MTTP ITIH1

3.09e-04187774edb0ab0154542b1c0b3a2c216c4a60f0f06290b3
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

LIFR PDE4D GRIK4 COL1A2

3.09e-04187774a9316e2818217ec5feae9cf8816f7249803caee6
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SALL1 UPF2 TLR7 CX3CR1

3.09e-04187774ba822dbceb47257129d6a8c9639c08d76de6d6a3
ToppCellfacs-Spleen-nan-3m-Lymphocytic-CD79a_B_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC12A6 FAM111A SYVN1 COL1A2

3.09e-04187774b51af2824e65734f333b1325117f4a2e88b17c23
ToppCellCOPD-Epithelial-ATII|Epithelial / Disease state, Lineage and Cell class

FASN PDE4C PDE4D CACNA2D2

3.09e-04187774030af361f8bdcd0aff4ec1922702833325cf74d8
ToppCellfacs-Spleen-nan-3m-Lymphocytic-B_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC12A6 FAM111A SYVN1 COL1A2

3.09e-041877743ca3954f45f167e98a230f2847f0582d74fcd32e
ToppCell10x3'2.3-week_12-13-Lymphocytic_NK-T_NK-ILC_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

PDE4D ZSWIM5 CHST9 CHRM3

3.09e-04187774f31d865ce2a21bdf64dbe29ee3e4505ab482604a
ToppCellCOVID-19-Epithelial_cells-Airway_basal|COVID-19 / group, cell type (main and fine annotations)

PDE4D KRT17 PKP1 CHST9

3.09e-041877748407a82e98f56a94ea26562bcb6bbe00a8f41661
ToppCellMesenchymal-chondrocyte|World / Lineage, Cell type, age group and donor

SOX6 GLT8D2 ITIH6 COL1A2

3.15e-041887747b1e3f8a941eaa68e89c562129a92314642eec66
ToppCellPericytes-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

GLT8D2 LRRN3 ITIH1 COL1A2

3.15e-0418877414c1c88a944c66f2eaac1ce7526815dcce1f5147
ToppCellfacs-Brain_Myeloid-Striatum-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR SALL1 TLR7 CX3CR1

3.21e-041897746dd4ec5ce4beb856f0d2d1654e3c4676d1d63736
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PDE4D XPO4 LRBA KIF20B

3.21e-04189774d05e043d0874b8563b9f5514f6c884b35c603e3a
ToppCellfacs-Brain_Myeloid-Striatum-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR SALL1 TLR7 CX3CR1

3.21e-041897743ae479ec7e00c57127cbe51a398329b10ca9848c
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SOX6 ANK1 MTTP ITIH1

3.21e-041897747899af78b273d9c7f029d52f7e0cf6df4da41f5e
DrugPiclamilast

PDE4B PDE4C PDE4D

1.43e-074763DB01791
DrugIbudilast

PDE4B PDE4C PDE4D

3.56e-075763DB05266
Drug1,7-naphthyridine

PDE4B PDE4C PDE4D

3.56e-075763CID000009209
DrugCyproheptadine

HTR2A CHRM2 CHRM3

7.10e-076763DB00434
DrugIloprost

PDE4B PDE4C PDE4D

1.24e-067763DB01088
DrugKetotifen

PDE4B PDE4C PDE4D

1.24e-067763DB00920
DrugParoxetine

HTR2A CHRM2 CHRM3

1.98e-068763DB00715
DrugDyphylline

PDE4B PDE4C PDE4D

1.98e-068763DB00651
Drugtrequinsin

PDE4B PDE4C PDE4D

2.96e-069763ctd:C035964
DrugRilapinum

HTR2A CHRM2 CHRM3

2.96e-069763CID006446980
DrugL-826,141

PDE4B PDE4C PDE4D

2.96e-069763ctd:C459562
Drugcanola oil

CUL1 LIFR PDE4B PDE4D MTTP TLR7

3.37e-06122766ctd:C061996
DrugNVP ABE171

PDE4B PDE4C PDE4D

4.22e-0610763ctd:C451724
DrugPromethazine

HTR2A CHRM2 CHRM3

4.22e-0610763DB01069
Drugtenilapine

HTR2A CHRM2 CHRM3

4.22e-0610763CID006450478
Drugolanzapine

PDE4B HTR2A MYO1A GPR85 CHRM2 CHRM3

4.65e-06129766CID000004585
DrugImipramine

HTR2A CHRM2 CHRM3

5.79e-0611763DB00458
Drugbenzotropine mesylate

HTR2A PIK3C2A CHRM2 CHRM3

6.96e-0637764CID000002344
DrugNortriptyline

HTR2A CHRM2 CHRM3

7.69e-0612763DB00540
DrugChlorprothixene

HTR2A CHRM2 CHRM3

7.69e-0612763DB01239
DrugDesipramine

HTR2A CHRM2 CHRM3

9.98e-0613763DB01151
DrugM 98

PDE4B PDE4D

1.10e-052762CID006420180
DrugV11294 Analogue 5f

PDE4B PDE4D

1.10e-052762CID011214587
DrugV11294 Analogue 5i

PDE4B PDE4D

1.10e-052762CID011376249
DrugV11294 Analogue 5t

PDE4B PDE4D

1.10e-052762CID011226695
DrugV11294 Analogue 5e

PDE4B PDE4D

1.10e-052762CID011443441
DrugV11294 Analogue 5d

PDE4B PDE4D

1.10e-052762CID011283750
DrugV11294 Analogue 5n

PDE4B PDE4D

1.10e-052762CID011238279
Drug3-cyclopentyloxy-4-methoxybenzoic acid

PDE4B PDE4D

1.10e-052762CID002779323
DrugV11294 Analogue 5v

PDE4B PDE4D

1.10e-052762CID011375325
DrugV11294 Analogue 5p

PDE4B PDE4D

1.10e-052762CID011478659
Drug3-cyclopentyloxy-4-methoxybenzaldehyde

PDE4B PDE4D

1.10e-052762CID002735893
DrugV11294 Analogue 5o

PDE4B PDE4D

1.10e-052762CID011249748
DrugV11294 Analogue 5c

PDE4B PDE4D

1.10e-052762CID011179896
DrugV11294 Analogue 5b

PDE4B PDE4D

1.10e-052762CID011443760
DrugCis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid

PDE4B PDE4D

1.10e-052762DB03849
DrugT-2585.HCl

PDE4B PDE4D

1.10e-052762CID006918355
DrugNp-V

PDE4B PDE4D

1.10e-052762CID009999276
DrugV11294 Analogue 5m

PDE4B PDE4D

1.10e-052762CID011477773
Drug(S)-Rolipram

PDE4B PDE4D

1.10e-052762DB03606
Drug1-((5-(1-aminoethyl)-2-(8-methoxy-2-(triflurormethyl)-5-quinolinyl)-4-oxazolyl) carbonyl)-4-((cyclopropylcarbonyl)amino)proline ethyl ester

PDE4B PDE4D

1.10e-052762ctd:C554440
DrugV11294 Analogue 8a

PDE4B PDE4D

1.10e-052762CID011442865
DrugV11294 Analogue 5r

PDE4B PDE4D

1.10e-052762CID011168555
DrugV11294 Analogue 5j

PDE4B PDE4D

1.10e-052762CID011433797
DrugV11294 Analogue 5q

PDE4B PDE4D

1.10e-052762CID011318772
DrugV11294 Analogue 5a

PDE4B PDE4D

1.10e-052762CID011386897
DrugV11294 Analogue 5k

PDE4B PDE4D

1.10e-052762CID011456440
DrugN-chloromethylbrucine

CHRM2 CHRM3

1.10e-052762ctd:C118330
DrugV11294 Analogue 5h

PDE4B PDE4D

1.10e-052762CID011306698
Drugcaracurine

CHRM2 CHRM3

1.10e-052762ctd:C006890
Drug3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester

PDE4B PDE4D

1.10e-052762DB01959
Drug4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone

PDE4B PDE4D

1.10e-052762DB01954
Drug(R)-Rolipram

PDE4B PDE4D

1.10e-052762DB04149
Drugpropiomazine

HTR2A CHRM2 CHRM3

1.27e-0514763CID000004940
DrugPromazine

HTR2A CHRM2 CHRM3

1.27e-0514763DB00420
DrugPropiomazine

HTR2A CHRM2 CHRM3

1.27e-0514763DB00777
DrugNSC172130

HTR2A CHRM2 CHRM3

1.58e-0515763CID000003155
DrugRoflumilast

PDE4B PDE4C PDE4D

1.94e-0516763ctd:C424423
Drugfelodipine

PDE4B PDE4C PDE4D CACNA2D2 AFF1 COL1A2

2.18e-05169766CID000003333
Drugrolipram

PDE4B PDE4C PDE4D GRIK4 GRIN2C LRBA CHRM2

2.19e-05253767CID000005092
DrugPGW5 compound

HTR2A CHRM2 CHRM3

2.35e-0517763ctd:C000593032
DrugAmitriptyline

HTR2A CHRM2 CHRM3

2.81e-0518763DB00321
DrugCilomilast

PDE4B PDE4C PDE4D

2.81e-0518763ctd:C433247
DrugRS 67333

PDE4B PDE4D HTR2A

2.81e-0518763CID000183782
DrugAnisotropine Methylbromide

CHRM2 CHRM3

3.29e-053762DB00517
DrugTridihexethyl

CHRM2 CHRM3

3.29e-053762DB00505
DrugOrg 4428

PDE4B PDE4D

3.29e-053762CID000166560
DrugMethylscopolamine

CHRM2 CHRM3

3.29e-053762DB00462
Drug1-Pyrrolidinebutanenitrile

PDE4B PDE4D

3.29e-053762CID000118838
DrugIpratropium bromide

CHRM2 CHRM3

3.29e-053762DB00332
DrugOxyphencyclimine

CHRM2 CHRM3

3.29e-053762DB00383
Drugbromomethane;[(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-propylpentanoate

CHRM2 CHRM3

3.29e-053762CID011954288
DrugTiotropium

CHRM2 CHRM3

3.29e-053762DB01409
DrugPipecuronium

CHRM2 CHRM3

3.29e-053762DB01338
DrugPancuronium

CHRM2 CHRM3

3.29e-053762DB01337
DrugDiphenidol

CHRM2 CHRM3

3.29e-053762DB01231
DrugPilocarpine

CHRM2 CHRM3

3.29e-053762DB01085
DrugOxybutynin

CHRM2 CHRM3

3.29e-053762DB01062
DrugBW A78U

PDE4B PDE4D

3.29e-053762CID000127779
Drug4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid

PDE4B PDE4D

3.29e-053762DB08299
Drug(1-(2,2-diphenyl-(1,3)dioxolan-4-yl)-ethyl)-dimethyl-amine

CHRM2 CHRM3

3.29e-053762ctd:C425227
Drugoxyphencyclimine

CHRM2 CHRM3

3.29e-053762CID000004642
Drugdarifenacin

CHRM2 CHRM3

3.29e-053762ctd:C101207
DrugMethotrimeprazine

HTR2A CHRM2 CHRM3

3.33e-0519763DB01403
Drugfemoxitine

HTR2A CHRM2 CHRM3

3.33e-0519763CID000043103
DrugRo-1724

PDE4B PDE4C PDE4D ACTL8 LRBA

3.38e-05110765CID000005087
Drugclozapine

PDE4B HTR2A GPR85 GRIK4 GRIN2C CHRM2 CHRM3

3.65e-05274767CID000002818
Drugbromperidol

HTR2A CHRM2 CHRM3

3.91e-0520763CID000002448
DrugDoxepin

HTR2A CHRM2 CHRM3

3.91e-0520763DB01142
DrugAA-2379

PDE4B PDE4C PDE4D

4.55e-0521763CID000128390
DrugPhenethicillin potassium salt [132-93-4]; Down 200; 10uM; PC3; HT_HG-U133A

LIFR PDE4C SALL1 FUT1 EDRF1 TIGD6

4.86e-051957665763_DN
DrugDiphenylpyraline hydrochloride [132-18-3]; Up 200; 12.6uM; MCF7; HT_HG-U133A

LRRN3 PDE4C GPR37 CEP250 EPS8L3 ITGB7

5.00e-051967666061_UP
DrugDehydrocholic acid [81-23-2]; Up 200; 9.6uM; MCF7; HT_HG-U133A

PDE4C ANK1 CELF3 PKP1 EPS8L3 COL1A2

5.14e-051977665681_UP
Drugsiguazodan

PDE4B PDE4C PDE4D

5.26e-0522763CID000072124
DrugHWA 153

PDE4B PDE4C PDE4D

5.26e-0522763CID000162797
DrugCX516

HTR2A GRIK4 GRIN2C

5.26e-0522763CID000148184
DrugProtriptyline hydrochloride [1225-55-4]; Down 200; 13.4uM; MCF7; HT_HG-U133A

IPO5 ACAD8 ACTL8 CACNA2D2 TICAM1 CEP250

5.29e-051987666498_DN
DrugSuccinylsulfathiazole [116-43-8]; Up 200; 11.2uM; MCF7; HT_HG-U133A

PDE4C ACTL8 CEP250 CDKL3 OR1G1 EDRF1

5.44e-051997664847_UP
DrugDeptropine citrate [2169-75-7]; Up 200; 7.6uM; MCF7; HT_HG-U133A

IPO5 PDE4B ACTL8 CDKL3 EDRF1 COL1A2

5.44e-051997665543_UP
Drugatherosperminine

PDE4B PDE4C PDE4D

6.03e-0523763CID000096918
DiseaseDepression, Bipolar

PDE4B HTR2A GRIK4 ITIH1

4.50e-0579734C0005587
Diseaseobesity (is_implicated_in)

HTR2A MTTP CX3CR1 FFAR4

7.83e-0591734DOID:9970 (is_implicated_in)
Diseaseectodermal dysplasia (is_implicated_in)

KRT17 PKP1

1.26e-047732DOID:2121 (is_implicated_in)
Diseaseamino acid measurement

SOX6 IPO5 PDE4D ACAD8 OR1G1 LRBA CHRM2 CHRM3

2.69e-04678738EFO_0005134
DiseaseSchizophrenia

IPO5 LIFR PDE4B PDE4D HTR2A GRIK4 GRIN2C CHRM2 ITIH1

3.23e-04883739C0036341
DiseaseManic Disorder

PDE4B HTR2A ITIH1

7.36e-0471733C0024713
Diseasemajor depressive disorder (is_implicated_in)

HTR2A CHRM2

8.02e-0417732DOID:1470 (is_implicated_in)
Diseaseurate measurement, bone density

SALL1 HTR2A SEC31A GRIN2C CHRM3 SLC38A3 DNAH1

8.51e-04619737EFO_0003923, EFO_0004531
Diseasevital capacity

SOX6 CSE1L KRT17 CACNA2D2 ZBTB4 MTTP AFF1 GATA5 LRBA COL1A2

9.05e-0412367310EFO_0004312
DiseaseManic

PDE4B HTR2A ITIH1

9.67e-0478733C0338831
DiseaseBipolar Disorder

SLC12A6 PDE4B HTR2A GRIK4 CHRM2 ITIH1

1.18e-03477736C0005586
Diseasesunburn

SOX6 PDE4B PDE4D

1.76e-0396733EFO_0003958

Protein segments in the cluster

PeptideGeneStartEntry
AYTQALMQQQAALVA

CELF3

206

Q5SZQ8
LMQQQAALVAAHSAY

CELF3

211

Q5SZQ8
SEVDANLMLALYNNS

CACNA2D2

916

Q9NY47
SNQYLQFTLADMATR

ACAD8

311

Q9UKU7
SVLLADQLQMSLYAS

ACTL8

126

Q9H568
NANMENLYTALQSID

ANK1

1461

P16157
TNSNLMAANLSSNLF

CDKL3

436

Q8IVW4
AIDYVASNASVMNLL

CHRM3

146

P20309
NSLMQLNDDTRLYSN

HTR2A

16

P28223
QNATNYFLMSLAIAD

HTR2A

106

P28223
DRYLAIVLAANSMNN

CX3CR1

126

P49238
ALDYVVSNASVMNLL

CHRM2

101

P08172
QASLDYLSNQVNELM

ANGPTL5

106

Q86XS5
AAYLSMSQGAVANAN

RBM14

556

Q96PK6
RANLSSQALQMSLDY

ITIH1

586

P19827
TALNVMQAQYARDAL

MYO1A

331

Q9UBC5
YMNQAAALQSERLVS

EDRF1

851

Q3B7T1
SRDLALMVAALAYNQ

CARMIL3

201

Q8ND23
SLANVVMNNRLALDY

ERVV-1

376

B6SEH8
FANSALNPILYNMTL

FFAR4

311

Q5NUL3
TAAAAIILNNNPSYM

MTTP

541

P55157
ELNSYLQSLMNASTD

PIK3C2A

1506

O00443
QFLINTNSELALMYN

PDE4B

456

Q07343
INTNSELALMYNDAS

PDE4C

441

Q08493
NQFLINTNSELALMY

PDE4D

511

Q08499
YRLDSIQAMNVALNT

EPS8L3

91

Q8TE67
YEQANLNMANSIKFS

KIF20B

256

Q96Q89
MTAVYLFSEALNAAQ

LRBA

361

P50851
MAAINSIYSNTDANI

GLT8D2

66

Q9H1C3
MAAAAAEQQQFYLLL

IPO5

1

O00410
SNVVQLIMDAYNSLS

ITGB7

376

P26010
MLANIQIQSQAISYS

OR1G1

81

P47890
MYQSLALAASPRQAA

GATA5

1

Q9BWX5
SSQLELMAASLYNNT

DNAH1

4056

Q9P2D7
ATQLAFMRLLANYAS

COL1A2

1251

P08123
ATMQNLNDRLASYLD

KRT17

86

Q04695
YMRSISNSLLANLAF

GPR37

291

O15354
LQASTFQMAILLQYN

CUL1

601

Q13616
NSSLYMALNTLQAVR

FAM111A

101

Q96PZ2
SLLVANLLAHMNYSF

EPHA8

396

P29322
AQAQAQLASLYSALQ

CEP250

1176

Q9BV73
SQYLKMAAANLTFSQ

HEATR4

61

Q86WZ0
AEYAAINSMLDQINS

BBLN

26

Q9BUW7
AQAMALLLYQTSANA

FAM43A

181

Q8N2R8
MNVILSDLQANDYFN

ITIH6

306

Q6UXX5
MANYSHAADNILQNL

GPR85

1

P60893
YTANLAAFLTVQRMD

GRIK4

636

Q16099
CSSSLMALQNAYQAI

FASN

161

P49327
VSSLLNRMANYTNLT

SLC12A6

146

Q9UHW9
YLQTMNSNLNLDGFL

SLC15A5

331

A6NIM6
QYAAALSNGLAMKAN

SALL1

1236

Q9NSC2
STFILLYLMNQVNSQ

LIFR

31

P42702
ATNTDLLLAYANLML

RGPD1

221

P0DJD0
EFAMSYQKLLANSQS

UPF2

401

Q9HAU5
AKQYFSSSMLNNIIN

PKP1

676

Q13835
NQMGQYATLLALAQL

FUT1

91

P19526
AAMLQINQYLTVLAS

SYVN1

516

Q86TM6
LVYAVQNNMAFLALS

SLC35A1

96

P78382
LNLANMLGYDNFQAS

TIGD6

106

Q17RP2
VSVVNNYALNLNIAM

SLC35B4

76

Q969S0
ALAITLQNIGAMSSY

SLC38A3

146

Q99624
LESLMLNSNALSALY

LRRN3

336

Q9H3W5
DTYGQALANTLMALQ

HMGCL

236

P35914
IEQLYAAQLASMQVS

SOX6

366

P35712
MAAQSSLYNDDRNLL

AFF1

1

P51825
LMVLNGLASSAYNIS

CHST9

231

Q7L1S5
YAEALSNQQKAVLMS

CLUH

1036

O75153
SLNQFMAVYKLNDNS

UHRF1BP1L

551

A0JNW5
SLAMSHLNLAYNQDT

ZSWIM5

1021

Q9P217
MVSTSLNAEALQYLQ

CSE1L

946

P55060
NAQMSSVFQRYLALA

XPO4

216

Q9C0E2
NMDSAYSEQAAVLLQ

ARHGAP40

176

Q5TG30
FENLILNQMNLSSYG

PYROXD1

471

Q8WU10
MQAAALNAAYSAYLQ

TICAM1

561

Q8IUC6
YNFSNLAALPVALNM

ZBTB4

936

Q9P1Z0
FELQVYRASMNLSQA

TLR7

351

Q9NYK1
SHVALALNLMRYNNS

TMEM222

146

Q9H0R3
GYRNFQMLLSSLLQN

ZUP1

361

Q96AP4
QMLLSSLLQNDAYND

ZUP1

366

Q96AP4
LAAKMSQYANLLAAQ

SEC31A

746

O94979
ASYTANLAAFMIQEQ

GRIN2C

641

Q14957