Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessinner ear development

CHD7 HMX2 TPRN CECR2 HMX3

5.55e-05253345GO:0048839
GeneOntologyBiologicalProcessinner ear morphogenesis

CHD7 HMX2 TPRN HMX3

5.86e-05129344GO:0042472
GeneOntologyBiologicalProcessear development

CHD7 HMX2 TPRN CECR2 HMX3

9.74e-05285345GO:0043583
GeneOntologyBiologicalProcessear morphogenesis

CHD7 HMX2 TPRN HMX3

1.16e-04154344GO:0042471
GeneOntologyCellularComponentchromatin

ANKRD17 POU2F2 ICE1 PRDM10 CHD7 HMX2 KMT2E CECR2 MEIS2 HMX3

1.42e-0414803610GO:0000785
GeneOntologyCellularComponenteuchromatin

ICE1 KMT2E CECR2

2.58e-0472363GO:0000791
HumanPhenoSecundum atrial septal defect

PRDM13 CHD7 GDF1 MEIS2

1.83e-0646114HP:0001684
HumanPhenoAbnormal lung lobation

PRDM10 RREB1 GDF1 MEIS2

2.00e-0647114HP:0002101
MousePhenoutricular degeneration

HMX2 HMX3

1.25e-053292MP:0004332
MousePhenoabnormal inner ear canal fusion

CHD7 HMX2

1.25e-053292MP:0002859
MousePhenoabnormal hypothalamus physiology

CHD7 HMX2 HMX3

2.02e-0526293MP:0005645
MousePhenodecreased superior semicircular canal size

CHD7 HMX3

2.49e-054292MP:0003166
MousePhenoabnormal crista ampullaris morphology

CHD7 HMX2 HMX3

2.54e-0528293MP:0004249
MousePhenoabnormal semicircular canal ampulla morphology

CHD7 HMX2 HMX3

3.82e-0532293MP:0008488
MousePhenodecreased posterior semicircular canal size

CHD7 HMX3

6.20e-056292MP:0003164
MousePhenovestibular saccular degeneration

HMX2 HMX3

8.67e-057292MP:0004329
MousePhenodecreased neuron number

PRDM13 CHD7 HMX2 RREB1 HMX3 SKOR2

1.02e-04376296MP:0008948
MousePhenoabsent posterior semicircular canal

CHD7 HMX3

1.48e-049292MP:0003163
MousePhenoabnormal pituitary gland morphology

CUL9 CHD7 HMX2 HMX3

1.64e-04135294MP:0000633
MousePhenoabnormal semicircular canal morphology

CHD7 HMX2 HMX3

2.41e-0459293MP:0002428
MousePhenoabnormal hypothalamus secretion

HMX2 HMX3

2.71e-0412292MP:0001752
MousePhenoabsent semicircular canals

HMX2 HMX3

2.71e-0412292MP:0000036
MousePhenoabnormal neuroendocrine gland morphology

CUL9 CHD7 HMX2 HMX3

2.85e-04156294MP:0000631
MousePhenoabnormal neuron number

PRDM13 CHD7 HMX2 RREB1 HMX3 SKOR2

2.92e-04456296MP:0008946
MousePhenoabnormal inner ear canal morphology

CHD7 HMX2 HMX3

2.93e-0463293MP:0002729
MousePhenoabsent lateral semicircular canal

CHD7 HMX3

3.20e-0413292MP:0003161
MousePhenodecreased vestibular hair cell number

HMX2 HMX3

4.90e-0416292MP:0004328
MousePhenoabnormal superior semicircular canal morphology

CHD7 HMX3

4.90e-0416292MP:0003069
MousePhenodecreased sensory neuron number

PRDM13 CHD7 HMX2 HMX3

5.01e-04181294MP:0000966
MousePhenodecreased circulating growth hormone level

HMX2 HMX3

5.54e-0417292MP:0005120
MousePhenoabnormal inner ear vestibule morphology

CHD7 HMX2 HMX3

6.14e-0481293MP:0000034
MousePhenoabnormal vestibular hair cell number

HMX2 HMX3

6.95e-0419292MP:0004326
MousePhenoblepharitis

CHD7 KMT2E

6.95e-0419292MP:0005251
MousePhenoabnormal posterior semicircular canal morphology

CHD7 HMX3

7.71e-0420292MP:0002858
MousePhenodecreased circulating pituitary hormone level

CHD7 HMX2 HMX3

8.09e-0489293MP:0005118
MousePhenoabnormal lateral semicircular canal morphology

CHD7 HMX3

8.52e-0421292MP:0000037
MousePhenoabnormal adenohypophysis morphology

CHD7 HMX2 HMX3

8.90e-0492293MP:0004163
MousePhenoabnormal hair cell morphology

CHD7 HMX2 TPRN HMX3

9.39e-04214294MP:0000045
MousePhenoabnormal vestibulocochlear nerve morphology

CHD7 MEIS2

1.02e-0323292MP:0001072
MousePhenosmall adenohypophysis

HMX2 HMX3

1.02e-0323292MP:0008321
MousePhenoabnormal mechanoreceptor morphology

CHD7 HMX2 TPRN HMX3

1.25e-03231294MP:0000972
MousePhenoabnormal eyelid morphology

CHD7 RREB1 CECR2 MEIS2

1.29e-03233294MP:0001340
DomainSET_dom

PRDM13 PRDM10 KMT2E

8.48e-0550323IPR001214
DomainSET

PRDM13 PRDM10 KMT2E

8.48e-0550323PS50280
DomainHomeobox

POU2F2 HMX2 MEIS2 HMX3

6.56e-04234324PF00046
DomainHOMEOBOX_1

POU2F2 HMX2 MEIS2 HMX3

6.77e-04236324PS00027
DomainHOX

POU2F2 HMX2 MEIS2 HMX3

6.88e-04237324SM00389
DomainHomeobox_dom

POU2F2 HMX2 MEIS2 HMX3

7.10e-04239324IPR001356
DomainHOMEOBOX_2

POU2F2 HMX2 MEIS2 HMX3

7.10e-04239324PS50071
Domain-

POU2F2 HMX2 MEIS2 HMX3

1.33e-032833241.10.10.60
DomainHomeodomain-like

POU2F2 HMX2 MEIS2 HMX3

2.38e-03332324IPR009057
DomainSET

PRDM13 KMT2E

2.81e-0346322SM00317
DomainHomeobox_CS

POU2F2 HMX2 HMX3

3.90e-03186323IPR017970
Pubmed

Investigation of PRDM10 and PRDM13 Expression in Developing Mouse Embryos by an Optimized PACT-Based Embryo Clearing Method.

PRDM13 PRDM10

1.10e-06237233809237
Pubmed

Molecular (SNP) analyses of overlapping hemizygous deletions of 10q25.3 to 10qter in four patients: evidence for HMX2 and HMX3 as candidate genes in hearing and vestibular function.

HMX2 HMX3

1.10e-06237219253379
Pubmed

Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia.

HMX2 HMX3

1.10e-06237233048949
Pubmed

Two highly related homeodomain proteins, Nkx5-1 and Nkx5-2, display different DNA binding specificities.

HMX2 HMX3

1.10e-06237210543441
Pubmed

Hmx: an evolutionary conserved homeobox gene family expressed in the developing nervous system in mice and Drosophila.

HMX2 HMX3

3.30e-06337211091080
Pubmed

Assignment of the murine Hmx2 and Hmx3 homeobox genes to the distal region of mouse chromosome 7.

HMX2 HMX3

3.30e-0633729421269
Pubmed

Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family.

HMX2 HMX3

3.30e-0633727647458
Pubmed

Regionalized expression of Nkx5-1, Nkx5-2, Pax2 and sek genes during mouse inner ear development.

HMX2 HMX3

6.60e-0643728970821
Pubmed

A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development.

HMX2 HMX3

6.60e-0643727510254
Pubmed

Nkx5-1 controls semicircular canal formation in the mouse inner ear.

HMX2 HMX3

6.60e-0643729389661
Pubmed

Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox genes during brain and ear development.

HMX2 HMX3

6.60e-0643728541222
Pubmed

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.

POU2F2 HMX2 LIMD1 MEIS2 HMX3

8.51e-0626337520932939
Pubmed

Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene.

HMX2 HMX3

3.95e-0593729435283
Pubmed

Hmx2 homeobox gene control of murine vestibular morphogenesis.

HMX2 HMX3

3.95e-05937211748138
Pubmed

Mutanlallemand (mtl) and Belly Spot and Deafness (bsd) are two new mutations of Lmx1a causing severe cochlear and vestibular defects.

HMX2 HMX3

7.22e-051237223226461
Pubmed

Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus.

POU2F2 HMX2 HMX3

7.68e-057737321525287
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ANKRD17 ZDBF2 ICE1 CHD7 RREB1

7.78e-0541837534709266
Pubmed

Differential expression of LIM domain-only (LMO) genes in the developing mouse inner ear.

HMX2 HMX3

8.53e-051337216597514
Pubmed

Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness.

HMX2 HMX3

9.94e-051437223457544
Pubmed

Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness.

HMX2 HMX3

1.15e-041537222383091
Pubmed

The sacral autonomic outflow is sympathetic.

HMX2 HMX3

1.31e-041637227856909
Pubmed

Delayed fusion and altered gene expression contribute to semicircular canal defects in Chd7 deficient mice.

CHD7 HMX3

1.31e-041637222705977
Pubmed

Retinoic acid synthesis and hindbrain patterning in the mouse embryo.

MEIS2 HMX3

1.48e-041737210654602
Pubmed

Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus.

HMX2 HMX3

1.48e-041737216900517
Pubmed

Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea.

CHD7 MEIS2

1.86e-041937234124068
Pubmed

Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear.

HMX2 HMX3

1.86e-041937219913004
Pubmed

Mash1 is required for generic and subtype differentiation of hypothalamic neuroendocrine cells.

HMX2 HMX3

2.07e-042037216469766
Pubmed

Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation.

LIMD1 MEIS2

2.07e-042037212447396
Pubmed

CHD7 regulates cardiovascular development through ATP-dependent and -independent activities.

SEMA6B CHD7

2.07e-042037233127760
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

CUL9 ZDBF2 CHD7 MEIS2

2.26e-0428237423667531
Pubmed

Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx.

HMX2 HMX3

2.28e-042137215363417
Pubmed

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis.

PRDM13 PRDM10

2.51e-042237219050759
Pubmed

Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.

CUL9 ZDBF2 ADAMTS7

2.59e-0411637330652415
Pubmed

Retinoic acid deficiency impairs the vestibular function.

HMX2 HMX3

3.52e-042637223536097
Pubmed

A census of human transcription factors: function, expression and evolution.

POU2F2 HMX2 RREB1 MEIS2 HMX3 SKOR2

3.63e-0490837619274049
Pubmed

The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development.

HMX2 MEIS2

4.09e-042837232868762
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

LIMD1 ATG3 PRRC2A MEIS2

8.35e-0439937435987950
Pubmed

OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum.

HMX2 HMX3

9.23e-044237226166575
Cytoband10q26.13

HMX2 HMX3

4.36e-043837210q26.13
GeneFamilyZinc fingers C2H2-type|PR/SET domain family

PRDM13 PRDM10

2.67e-04172621197
GeneFamilyNKL subclass homeoboxes and pseudogenes

HMX2 HMX3

4.15e-0367262519
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_2|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

POU2F2 KIF26B GPR132 P3H2

1.61e-051843740a26bcc6610f756939e32a4d6dfeebcbf3a1db86
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_2|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

POU2F2 KIF26B GPR132 P3H2

1.64e-05185374fec16a5e527fdef32d25957451b6e8ee9796cafd
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

POU2F2 CHD7 HMX2 HMX3

1.79e-051893743f5522be3e24dcdb6272f18cee2f239dfdeff9ad
ToppCellControl-Myeloid-ncMonocyte|Myeloid / Disease state, Lineage and Cell class

POU2F2 TBC1D30 LIMD1 WBP1L

1.94e-051933743479c01aaae7afd7e02d00e0cb21951c0106a0fd
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

POU2F2 CHD7 HMX2 HMX3

1.98e-051943745bd0f739aa75f387cca7c3b2686493ee2d1ee968
ToppCellControl-Myeloid-ncMonocyte|Control / Disease state, Lineage and Cell class

POU2F2 TBC1D30 LIMD1 WBP1L

2.02e-05195374fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCellControl-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class

POU2F2 TBC1D30 LIMD1 WBP1L

2.02e-05195374b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCelldistal-Hematologic-Interstitial_Macrophage-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SEMA6B POU2F2 GPR132 ASGR1

2.19e-05199374e25a67a196f226b60b4aa0ff0cf4471d66333445
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HAPLN3 PRR23A ZDBF2

1.19e-0411537336cbb8666b33199b7552879922789bc227525b7b
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HAPLN3 PRR23A ZDBF2

1.19e-041153736f92e45cbe9924ade10cb8a41884b0202070ab31
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-2|TCGA-Lung / Sample_Type by Project: Shred V9

LINC01356 HMX2 HMX3

2.45e-04147373457bc1175810f241ed8966b76ed4fc4ef3fb144c
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-NP-L5_NP_VISp_Trhr_Cpne7|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RREB1 MEIS2 STARD5

2.55e-041493738638b3819193d11411df58964069fec583f617f4
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMX2 ADAMTS7 HMX3

2.75e-041533733b1b0cc8e9dd2b1484649789330713282ee44414
ToppCellfacs-Heart-RA-24m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRDM13 GPR132 LACTBL1

2.86e-04155373cc3fc379ea78742a216317054f336331f7c7a157
ToppCellfacs-Heart-RA-24m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRDM13 GPR132 LACTBL1

2.86e-041553731900a76754e2a9c7117e531c5907b7942f72c4a6
ToppCellnormal_Pleural_Fluid-B_lymphocytes-Undetermined|normal_Pleural_Fluid / Location, Cell class and cell subclass

POU2F2 CHD7 KMT2E

3.14e-041603735744cd30709f38e84f7ec8893dc19d7a288b465a
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-Tuft|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMX2 LIMD1 HMX3

3.20e-04161373f5df8c6a340d5026726804b103e32137f363ca40
ToppCellnormal_Lymph_Node-B_lymphocytes-Undetermined|normal_Lymph_Node / Location, Cell class and cell subclass

POU2F2 CHD7 KMT2E

3.25e-0416237391ac35ae7fde411cd6a44e715a33dac62419cab8
ToppCellPND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POU2F2 PRDM10 GPR132

3.43e-0416537366f0364098d82629aa2ec1dfe0c5ad23de7c2c12
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMX2 LIMD1 HMX3

3.62e-041683738072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-stromal_related|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIF26B P3H2 MEIS2

3.62e-04168373e40a3f85be7e9bb23bfbc1f9cb5e5fc54bb43863
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIF26B P3H2 MEIS2

3.62e-04168373b1d6c35a5ae69c8638afd68c2be5bc9ce6fd2659
ToppCell3'-Child09-12-SmallIntestine-Epithelial-Tuft-related-Tuft|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMX2 LIMD1 HMX3

3.68e-0416937305e12524d68d409fed386ffad233305683b4575b
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l15|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

POU2F2 CHD7 GPR132

3.81e-0417137387cb65648c663e246f94cea1a5ed12e8e29ec629
ToppCelldroplet-Trachea-nan-3m-Myeloid-macrophage|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 CHD7 GPR132

3.88e-04172373f6c00a6a7e81aaf96c55eb3a3c88e3719f102ea0
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-tracheal_macrophage|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

POU2F2 CHD7 GPR132

3.88e-04172373f3bbe3f069ad070778430d1a6cd9db0a76deb8de
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 CECR2 LACTBL1

3.94e-04173373e944ea3a0a368f856efacbda4600605cf751dd9c
ToppCellfacs-Large_Intestine-Distal-24m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMX2 ADAMTS7 HMX3

3.94e-04173373f0eb48c1283bdde313bb75f6ffc0d2626922d24b
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 CECR2 LACTBL1

3.94e-0417337385fa5918e9c1f6bb4757e3350cfc71ee75c55640
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-31|World / Primary Cells by Cluster

KIF26B CECR2 MEIS2

4.08e-04175373491508bf9e8a09b057d5711cc23dd91324e6a806
ToppCellPND07-Epithelial-Epithelial_Airway-Neurosecretory|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HMX2 ASGR1 HMX3

4.08e-0417537319eda8b5d39dc93d79737ebdbeeba5ec0cb23c51
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMX2 ADAMTS7 HMX3

4.08e-04175373f24b664b9056b5976bf2222e8013f15c09e049ad
ToppCellnormal_Lung-T/NK_cells-Treg|normal_Lung / Location, Cell class and cell subclass

CUL9 HAPLN3 POU2F2

4.08e-04175373bc846312e6a6d68b7ca661052fb4e02cfb8ed014
ToppCellfacs-Trachea-24m-Hematologic-lymphocytic-B_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

POU2F2 CECR2 STARD5

4.15e-04176373318dc722b95e269002fb01a0feb91c0c8539e150
ToppCellfacs-Trachea-24m-Hematologic-lymphocytic-B_cell-B_cell_of_the_trachea|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

POU2F2 CECR2 STARD5

4.15e-04176373f6891006d816309edabe75b2abf60675f2958e55
ToppCellFF-Differ-KC|World / shred by cell class for mouse tongue

TBC1D30 KIF26B SLC23A3

4.36e-041793731526a130565a97c291a25a7a988089bffc1515c1
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_8|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SEMA6B POU2F2 P3H2

4.36e-041793730624dd537a68736f4d7b8b4de2c56168ed0e60a9
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_8|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SEMA6B POU2F2 P3H2

4.36e-04179373163f5430d72ea0c1b239ea5d21e53be536636d3d
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-CD141+_DCs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

POU2F2 HMX2 ATG3

4.36e-0417937399894067e2c2a3ed53abdc5434410c3172693496
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

POU2F2 CHD7 HMX2

4.50e-041813737f99002a6411117cc2361334c7c9228e20c574b4
ToppCelldroplet-Kidney-nan-21m-Epithelial-Epcam____kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMX2 KIF26B HMX3

4.57e-04182373fe4fb213dc0ca482b0f94097fe1b0a51fc2690e2
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CHD7 LIMD1 CECR2

4.57e-041823738a8b08ac4bb3cba3541dbe234e088703842285b9
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CHD7 LIMD1 CECR2

4.57e-04182373e36766309c4d96a90d213ce37d3acef1029a3fdc
ToppCellDendritic_Cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

HAPLN3 LINC01356 GPR132

4.65e-04183373499da89b4abe7b746e703cd1e5c56f9b1d97ac3c
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA6B HAPLN3 TNS2

4.65e-04183373a644258ba90acc62d571623e429d72ffc4b69203
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Lymphocytic-B_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 KMT2E GPR132

4.65e-04183373544939a0bfef082d361d88ef70d6f0923b8d9af9
ToppCell10x5'-lymph-node_spleen-Myeloid_Dendritic-DC1|lymph-node_spleen / Manually curated celltypes from each tissue

LINC01356 ATG3 P3H2

4.65e-04183373c9e3d91f4c3395a73295b92e25608e0effb5d241
ToppCell3'_v3-GI_small-bowel-Myeloid_Dendritic-DC1|GI_small-bowel / Manually curated celltypes from each tissue

LINC01356 P3H2 CECR2

4.72e-041843738e393eea7240584a3cef718bee094e2705ec1891
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEMA6B POU2F2 GPR132

4.72e-04184373b45b1fdba13c8ed2a04a4fb3b62d8ad92785c768
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CHD7 LIMD1 CECR2

4.79e-041853737aaa8335b40927e3e8fdcede807cd521fc213a0d
ToppCellnormal_Lung-T/NK_cells-Treg|T/NK_cells / Location, Cell class and cell subclass

CUL9 HAPLN3 POU2F2

4.79e-04185373ea416362d3f06b4a0a7f08c2e5dbbc864f121555
ToppCellBrain_organoid-organoid_Kanton_Nature|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.

ICE1 CHD7 KMT2E

4.79e-04185373857c7ca8493e91ef1d0078ddafd6082020f9b169
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

POU2F2 ZDBF2 KMT2E

4.79e-04185373e913c64f9b4873443d88dce270f0b7b6d1b4cbce
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CHD7 LIMD1 CECR2

4.79e-041853732e1766f1a972fecd670daaaf7eb2d3a404f121e7
ToppCellMild_COVID-19-Epithelial-AT1/AT2|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

KIF26B P3H2 MEIS2

4.79e-04185373c55fdba1e3818ec0404d7ab473bf18dd25f2bb0a
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

KIF26B P3H2 MEIS2

4.87e-041863738915436d09775f2828a7678af203b1082b36e21c
ToppCellTuft|World / Class top

HMX2 HMX3 STARD5

4.87e-04186373f4d83f15ab7b49c0920a322cd832413ece7c9948
ToppCellTuft-tuft-2|World / Class top

HMX2 HMX3 STARD5

4.95e-041873734ec6eee866619dfe13c84f5d2e812bb380d37139
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CHD7 LIMD1 CECR2

4.95e-04187373daff7ccd3f1924cf2b34d3aca3eccde245aaf371
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CHD7 LIMD1 CECR2

4.95e-041873735b7a1edee602e55d3400dc17dbb6b8aaa26defc0
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMX2 KIF26B HMX3

5.02e-04188373315ce1736e3a84a63a8d5dfa70d411b501cb2532
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B TNS2 MEIS2

5.02e-04188373a37edd8f9e4a4e336b5acbb0407d3d275975cee8
ToppCell10x5'-GI_large-bowel-Myeloid_Monocytic|GI_large-bowel / Manually curated celltypes from each tissue

SEMA6B TNS2 ASGR1

5.02e-04188373d0045fdda757d191dabc7853f6a6e99c0e97d93d
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHD7 HMX2 HMX3

5.02e-04188373459e3fd4335a6f25f982d011b38702f4fcfed1cd
ToppCellwk_08-11-Epithelial-PNS-MFNG+_DBH+_neuron|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CHD7 HMX2 HMX3

5.02e-04188373d3d7d21d4fa39ac4106a164652673de1bef8662d
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neuron_precursor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHD7 HMX2 HMX3

5.02e-041883739fd262bbf6cdebfd945e39428a6059726fb55b3a
ToppCell10x5'-GI_large-bowel-Myeloid_Monocytic-Classical_monocytes|GI_large-bowel / Manually curated celltypes from each tissue

SEMA6B TNS2 ASGR1

5.02e-041883730bcf04aa47738f43c1a87dae5dc487738ee86f8c
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CHD7 RREB1 CECR2

5.10e-0418937342ab4cc5fbf8580841f31889446fe4499df1a464
ToppCellE12.5-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CHD7 HMX2 HMX3

5.10e-04189373620d30bb6211fff6adab0638d0d994f547167a29
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEMA6B GPR132 ASGR1

5.18e-04190373a5c64d024f2908d30d1e2897a45baf3a67b103b5
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

KIF26B P3H2 MEIS2

5.26e-04191373156b467187331ac6ca390d6ca861d9670bb7b956
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_dendritic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SEMA6B POU2F2 GPR132

5.26e-04191373a5ee4d72b2311c8fa98ff73adc2499debb2014f1
ToppCell5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMX2 LIMD1 HMX3

5.26e-0419137354f07e4de61735051498846afb44b1798bed8144
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHD7 HMX2 HMX3

5.26e-04191373c7b95a5f9185d533c08754ce2e4ce91533eb612e
ToppCellT_cells-Central_memory_CD4+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

HAPLN3 POU2F2 CHD7

5.26e-0419137325dd538d6a361bd3367c8a1c0dfc9e7003061af3
ToppCelldroplet-Heart-nan-18m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HAPLN3 MEIS2 WBP1L

5.34e-041923730b9b2eaed45456d7d74ce78a64ef4a26ac2458fb
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

POU2F2 CHD7 HMX2

5.34e-04192373d8f5df2c2a50e567f24ebecc8033ac97ba89d9c5
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

POU2F2 HMX2 HMX3

5.34e-04192373307d64ef7add6a2778733e9945a1bd687feb6f44
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHD7 HMX2 HMX3

5.34e-0419237356f2388c9c4e19883ae5cff332c77f596ff744a8
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

POU2F2 LINC01356 CECR2

5.34e-0419237369758a256386a6ed3a6e2c94c55d59baa34892d7
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_B|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

POU2F2 CHD7 HMX2

5.42e-041933739661ea0ee7273928c7de2a9f49e853595fa77699
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-IPC_like|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

CHD7 KIF26B MEIS2

5.42e-04193373f24bae40f5cbcfece04fbefe4e3de1b88ac90de4
ToppCellmetastatic_Lymph_Node-T/NK_cells-Treg|T/NK_cells / Location, Cell class and cell subclass

CUL9 HAPLN3 POU2F2

5.42e-04193373bac302e69455aaaf1c18f3272bb213242664d747
ToppCell(07)_Brush|World / shred by cell type and Timepoint

HMX2 HMX3 STARD5

5.42e-041933739af9d22a130ff97a9c37142a65e841b056d08640
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B TNS2 MEIS2

5.42e-04193373cc355b2ed6510619cad969ae074126d7c8db784d
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-IPC_like-IPCs|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

CHD7 KIF26B MEIS2

5.42e-041933732088f1d210c73f74685492c63065c62ac3f553e9
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-Treg|T/NK_cells / Location, Cell class and cell subclass

CUL9 HAPLN3 POU2F2

5.51e-04194373e46963d5f156526342ebc0fb9e767d266e812c42
ToppCelldistal-Hematologic-Myeloid_Dendritic_Type_2-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SEMA6B POU2F2 GPR132

5.59e-041953737606b8b40e704bb5447ac57ccf8698794e9c7890
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 LIMD1 CECR2

5.59e-04195373d77423d0ec64b397c6d1eec181c5fc0acaa92d63
ToppCelltumor_Lung-T/NK_cells-Treg|T/NK_cells / Location, Cell class and cell subclass

CUL9 HAPLN3 POU2F2

5.59e-04195373dd112ef3f8bd0790719827b6bb120918687afdff
ToppCellHealthy_Control-Myeloid-mDC-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

POU2F2 GPR132 P3H2

5.59e-04195373d9a6fc7fa0047472821e1dcf0962ccb3f061313e
ToppCellnormal_Lung-B_lymphocytes-Follicular_B_cells|B_lymphocytes / Location, Cell class and cell subclass

POU2F2 CHD7 KMT2E

5.59e-041953732a9a2b36a9a4ce72a3b855c0872214f38a7c64b0
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

POU2F2 CHD7 HMX2

5.59e-04195373b25c534fc6320d4da6437ef1b27e32a5d5256f3e
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 LIMD1 CECR2

5.59e-04195373f5bf4797972185afa76638293166abd536e5472f
ToppCellHealthy_Control-Myeloid-mDC|Healthy_Control / Condition, Lineage, Cell class and cell subclass

POU2F2 GPR132 P3H2

5.59e-0419537332f505b2c24f4386367706b775e79271f99156f2
ToppCellwk_08-11-Epithelial-PNS-TM4SF4+_PENK+_neuron|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

POU2F2 HMX2 HMX3

5.67e-04196373afa3a2f5f3a51d1830c6f95f97a4b3e13ed42512
ToppCelldroplet-Heart-nan-18m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HAPLN3 MEIS2 WBP1L

5.67e-04196373e386526332138e636aef2542c11316347a45689c
ToppCellTransverse-B_cell-B_cell_IgG_Plasma|B_cell / Region, Cell class and subclass

HMX2 TBC1D30 PRR33

5.76e-04197373a0a096e8e80763a92d5d7396eb678a4587771a3a
ToppCellBAL-Control-Myeloid-cDC-cDC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

POU2F2 GPR132 P3H2

5.76e-041973736f83fc049f38f3de6bc5180ad4b51ceb4d5dcdb6
ToppCell343B-Endothelial_cells-Endothelial-A_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SEMA6B HAPLN3 SLC23A3

5.76e-04197373ec92d60f802c9d4bdf9877bed5c0a91a5a5ed5d0
Diseasepappalysin-1 measurement

SEMA6B CHD7

2.04e-056352EFO_0802845
Diseasetestosterone measurement

CHD7 RREB1 P3H2 ASGR1 TPRN CECR2 WBP1L SKOR2

9.86e-051275358EFO_0004908
Diseasecortical surface area measurement

CUL9 PRR23A CHD7 RREB1 ADAMTS7 KIF26B PRRC2A MEIS2

1.43e-041345358EFO_0010736
Diseasefree androgen index

CHD7 RREB1 WBP1L SKOR2

9.75e-04374354EFO_0007005
DiseaseCongenital Heart Defects

GDF1 MEIS2

1.25e-0344352C0018798
Diseasebehavior

LINC01356 MEIS2

1.95e-0355352GO_0007610
Diseasealcohol drinking

ICE1 KMT2E

4.18e-0381352EFO_0004329
Diseasedaytime rest measurement

PRDM13 KIF26B SKOR2

5.11e-03295353EFO_0007828

Protein segments in the cluster

PeptideGeneStartEntry
SDHHQLRKGPPPPQP

ASGR1

16

P07306
PAIRPPPHGTTAPHK

ANKRD17

2176

O75179
LPTCPPLQPHPGLHH

CHD7

511

Q9P2D1
RPPCKSAGHRLQPPP

CECR2

861

Q9BXF3
PHLPPPPMCSVHPCR

ATG3

251

Q9NT62
RPLRPFHCQPGPAKP

ADAMTS7

1496

Q9UKP4
FHCQPGPAKPPAHRP

ADAMTS7

1501

Q9UKP4
VRYPVVHPHPNCGPP

HAPLN3

321

Q96S86
PPLPKPCGDHPLNHR

LIMD1

216

Q9UGP4
LLNGDHHRPPPKPQP

HMX3

36

A6NHT5
RPIPPVHHLNHGPPL

MEIS2

31

O14770
HCVLARPKGTPPLPP

KIF26B

1586

Q2KJY2
MPPPQQGPCGHHLLL

GDF1

1

P27539
HGPKEQGPKHHPPIP

HMX2

71

A2RU54
QGPKHHPPIPFPCLG

HMX2

76

A2RU54
DPHLSHPQPPKCLEP

POU2F2

176

P09086
HPQPPKCLEPPSHPE

POU2F2

181

P09086
PTKLHCPPSPHLENP

KMT2E

1436

Q8IZD2
CPKHGPLHPIPNRPV

PRDM10

186

Q9NQV6
RHCAARHPLPPPPPG

P3H2

86

Q8IVL5
PKHALPVPGRLPPCA

ICE1

1721

Q9Y2F5
MCPRHPEPVPLAHPL

LACTBL1

1

A8MY62
CHLLVHVEPPPGPSP

CUL9

1426

Q8IWT3
HHHPKCLLAGDPPPP

PRDM13

361

Q9H4Q3
RPVHPPGSPCPAKRL

GPR132

361

Q9UNW8
HAHPPLPKRPPCKAR

PRR23A

246

A6NEV1
HPRHKPGLPQAPQGP

PRRC2A

1496

P48634
ALCGRLLHLPPPPPH

SLC23A3

336

Q6PIS1
LLHLPPPPPHACSRG

SLC23A3

341

Q6PIS1
HPPSPLSKCPQHPRP

LINC00477

131

Q96M19
PQKRLPTPHPHPHAL

SEMA6B

716

Q9H3T3
HRGPTQPPPPHVSIK

RREB1

871

Q92766
HVEHPLCPPKPGFVR

STARD5

136

Q9NSY2
PCHRHPPAERPPKQK

ZDBF2

1916

Q9HCK1
RVHPPCQRHCPEPPS

TBC1D30

836

Q9Y2I9
PHPCPVPKVAPKPRL

PRR33

176

A8MZF0
KRALPQPGAHPACHP

SKOR2

241

Q2VWA4
EPLCPLKHPSHRPPA

nan

26

Q8NA96
PHPARPLHPARPGCV

TPRN

476

Q4KMQ1
PAPRRLPGCQRHPHP

LINC01356

51

Q8N9X3
RHPHPFKCCPVPAPQ

LINC01356

61

Q8N9X3
GHPHLPRPPACLLLN

WBP1L

311

Q9NX94
AGKPLLHPVRPGHPL

TNS2

721

Q63HR2