Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1	4.18e-10	151	79	10	GO:0015085
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	ANO9 CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 SLC39A11 SCN3A OTOP2 CACNA1I CACNA1H GRIN2C GRIN2D SLC45A1 SLC24A1 PLP2 ANO3 SLC45A4	1.41e-09	793	79	18	GO:0015075
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	ANO9 CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 SLC39A11 SCN3A OTOP2 CACNA1I CACNA1H GRIN2C GRIN2D SLC45A1 SLC24A1 ANO3 SLC45A4	5.21e-09	758	79	17	GO:0015318
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 SLC39A11 SCN3A OTOP2 CACNA1I CACNA1H GRIN2C GRIN2D SLC45A1 SLC24A1 SLC45A4	2.02e-08	627	79	15	GO:0022890
GeneOntologyMolecularFunction	transmembrane transporter activity	ANO9 CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 SLC39A11 SCN3A SLC22A15 OTOP2 SLC19A3 CACNA1I CACNA1H GRIN2C GRIN2D SLC45A1 SLC24A1 PLP2 ANO3 SLC45A4	2.15e-08	1180	79	20	GO:0022857
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 SLC39A11 SCN3A OTOP2 CACNA1I CACNA1H GRIN2C GRIN2D SLC45A1 SLC24A1 SLC45A4	4.30e-08	664	79	15	GO:0008324
GeneOntologyMolecularFunction	calcium channel activity	CACNB1 CACNB4 TRPM5 CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1	4.33e-08	129	79	8	GO:0005262
GeneOntologyMolecularFunction	transporter activity	ANO9 CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 SLC39A11 SCN3A SLC22A15 OTOP2 SLC19A3 CACNA1I CACNA1H GRIN2C GRIN2D SLC45A1 SLC24A1 PLP2 ANO3 SLC45A4	9.24e-08	1289	79	20	GO:0005215
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNB1 CACNB4 CACNA1I CACNA1H	2.20e-07	14	79	4	GO:0008331
GeneOntologyMolecularFunction	monoatomic ion channel activity	ANO9 CACNB1 CACNB4 TRPM5 SCN3A OTOP2 CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1 ANO3	2.40e-07	459	79	12	GO:0005216
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 SLC39A11 SCN3A CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1	2.75e-07	465	79	12	GO:0046873
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNB1 CACNB4 TRPM5 SCN3A OTOP2 CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1	9.89e-07	343	79	10	GO:0005261
GeneOntologyMolecularFunction	channel activity	ANO9 CACNB1 CACNB4 TRPM5 SCN3A OTOP2 CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1 ANO3	9.94e-07	525	79	12	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	ANO9 CACNB1 CACNB4 TRPM5 SCN3A OTOP2 CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1 ANO3	1.01e-06	526	79	12	GO:0022803
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC8A2 SLC8A3 TRPM5 SCN3A CACNA1I CACNA1H SLC24A1	5.16e-06	171	79	7	GO:0015081
GeneOntologyMolecularFunction	gated channel activity	ANO9 CACNB1 CACNB4 TRPM5 CACNA1I CACNA1H GRIN2C GRIN2D ANO3	6.77e-06	334	79	9	GO:0022836
GeneOntologyMolecularFunction	calcium:sodium antiporter activity	SLC8A2 SLC8A3 SLC24A1	7.01e-06	10	79	3	GO:0005432
GeneOntologyMolecularFunction	RNA helicase activity	DDX17 MOV10L1 DDX42 DDX3Y SNRNP200	1.44e-05	78	79	5	GO:0003724
GeneOntologyMolecularFunction	histone H2BS36 kinase activity	PRKAA1 PRKAA2	1.55e-05	2	79	2	GO:0140823
GeneOntologyMolecularFunction	[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity	PRKAA1 PRKAA2	1.55e-05	2	79	2	GO:0047322
GeneOntologyMolecularFunction	histone H2B kinase activity	PRKAA1 PRKAA2	1.55e-05	2	79	2	GO:0140998
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	DDX17 MOV10L1 DDX42 DDX3Y SNRNP200	1.63e-05	80	79	5	GO:0008186
GeneOntologyMolecularFunction	calcium:monoatomic cation antiporter activity	SLC8A2 SLC8A3 SLC24A1	1.66e-05	13	79	3	GO:0015368
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNB1 CACNB4 CACNA1I CACNA1H	3.26e-05	46	79	4	GO:0005245
GeneOntologyMolecularFunction	low voltage-gated calcium channel activity	CACNA1I CACNA1H	4.62e-05	3	79	2	GO:0008332
GeneOntologyMolecularFunction	calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	SLC8A2 SLC8A3	4.62e-05	3	79	2	GO:1905060
GeneOntologyMolecularFunction	olfactory receptor activity	OR1M1 OR4M2 OR51F2 OR4M1 OR2C3 OR13G1 OR5M3 OR4M2B OR52J3	5.06e-05	431	79	9	GO:0004984
GeneOntologyMolecularFunction	sodium channel activity	TRPM5 SCN3A CACNA1I CACNA1H	5.32e-05	52	79	4	GO:0005272
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNB1 CACNB4 CACNA1I CACNA1H GRIN2C GRIN2D	8.46e-05	182	79	6	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNB1 CACNB4 CACNA1I CACNA1H GRIN2C GRIN2D	8.98e-05	184	79	6	GO:0022832
GeneOntologyMolecularFunction	sucrose:monoatomic cation symporter activity	SLC45A1 SLC45A4	9.23e-05	4	79	2	GO:0009669
GeneOntologyMolecularFunction	ornithine decarboxylase activity	AZIN2 ODC1	9.23e-05	4	79	2	GO:0004586
GeneOntologyMolecularFunction	sucrose transmembrane transporter activity	SLC45A1 SLC45A4	9.23e-05	4	79	2	GO:0008515
GeneOntologyMolecularFunction	sucrose:proton symporter activity	SLC45A1 SLC45A4	9.23e-05	4	79	2	GO:0008506
GeneOntologyMolecularFunction	oligosaccharide transmembrane transporter activity	SLC45A1 SLC45A4	9.23e-05	4	79	2	GO:0015157
GeneOntologyMolecularFunction	disaccharide transmembrane transporter activity	SLC45A1 SLC45A4	9.23e-05	4	79	2	GO:0015154
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN3A CACNA1I CACNA1H	1.45e-04	26	79	3	GO:0005248
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	TRPM5 GRIN2C GRIN2D	2.47e-04	31	79	3	GO:0099604
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNB1 CACNB4 CACNA1I CACNA1H GRIN2D	3.43e-04	152	79	5	GO:0022843
GeneOntologyMolecularFunction	helicase activity	DDX17 MOV10L1 DDX42 DDX3Y SNRNP200	4.09e-04	158	79	5	GO:0004386
GeneOntologyMolecularFunction	carbohydrate:proton symporter activity	SLC45A1 SLC45A4	4.26e-04	8	79	2	GO:0005351
GeneOntologyMolecularFunction	glutamate-gated calcium ion channel activity	GRIN2C GRIN2D	4.26e-04	8	79	2	GO:0022849
GeneOntologyMolecularFunction	NMDA glutamate receptor activity	GRIN2C GRIN2D	4.26e-04	8	79	2	GO:0004972
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	SLC8A2 SLC8A3 SLC24A1	6.56e-04	43	79	3	GO:0140828
GeneOntologyMolecularFunction	AMP-activated protein kinase activity	PRKAA1 PRKAA2	6.81e-04	10	79	2	GO:0004679
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	ANO9 TRPM5 GRIN2C GRIN2D ANO3	1.01e-03	193	79	5	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	ANO9 TRPM5 GRIN2C GRIN2D ANO3	1.11e-03	197	79	5	GO:0022834
GeneOntologyMolecularFunction	carbohydrate:monoatomic cation symporter activity	SLC45A1 SLC45A4	2.02e-03	17	79	2	GO:0005402
GeneOntologyMolecularFunction	glutamate-gated receptor activity	GRIN2C GRIN2D	2.02e-03	17	79	2	GO:0004970
GeneOntologyMolecularFunction	myosin V binding	RAB3A RAB3B	2.80e-03	20	79	2	GO:0031489
GeneOntologyMolecularFunction	intracellularly calcium-gated channel activity	ANO9 ANO3	2.80e-03	20	79	2	GO:0141147
GeneOntologyMolecularFunction	intracellularly calcium-gated chloride channel activity	ANO9 ANO3	2.80e-03	20	79	2	GO:0005229
GeneOntologyMolecularFunction	phospholipid scramblase activity	ANO9 ANO3	3.70e-03	23	79	2	GO:0017128
GeneOntologyMolecularFunction	GTP-dependent protein binding	RAB3A RAB3B	4.03e-03	24	79	2	GO:0030742
GeneOntologyMolecularFunction	solute:proton symporter activity	SLC45A1 SLC45A4	4.37e-03	25	79	2	GO:0015295
GeneOntologyMolecularFunction	glutamate receptor activity	GRIN2C GRIN2D	5.09e-03	27	79	2	GO:0008066
GeneOntologyMolecularFunction	histone kinase activity	PRKAA1 PRKAA2	5.47e-03	28	79	2	GO:0035173
GeneOntologyMolecularFunction	catalytic activity, acting on RNA	XRN2 DDX17 MOV10L1 DDX42 DDX3Y SNRNP200	6.17e-03	417	79	6	GO:0140098
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC8A2 SLC8A3 SLC45A1 SLC24A1 SLC45A4	6.39e-03	296	79	5	GO:0015291
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR1M1 OR4M2 OR51F2 OR4M1 OR2C3 OR13G1 OR5M3 GRIN2C GRIN2D PLXNA1 OR4M2B OR52J3	6.69e-03	1353	79	12	GO:0004888
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC8A2 SLC8A3 SLC45A1 SLC24A1 SLC45A4	6.84e-03	301	79	5	GO:0022853
GeneOntologyMolecularFunction	modified amino acid transmembrane transporter activity	SLC22A15 SLC19A3	7.54e-03	33	79	2	GO:0072349
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR1M1 OR4M2 OR51F2 OR4M1 OR2C3 OR13G1 OR5M3 OR4M2B OR52J3	8.06e-03	884	79	9	GO:0004930
GeneOntologyMolecularFunction	carboxy-lyase activity	AZIN2 ODC1	8.92e-03	36	79	2	GO:0016831
GeneOntologyBiologicalProcess	calcium ion transmembrane transport	CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 FBXO11 CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1	2.88e-07	392	79	11	GO:0070588
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	ANO9 CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 SLC39A11 SCN3A OTOP2 FBXO11 CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1 PLP2 ANO3	8.45e-07	1115	79	17	GO:0034220
GeneOntologyBiologicalProcess	calcium ion import across plasma membrane	SLC8A2 SLC8A3 CACNA1I CACNA1H SLC24A1	1.09e-06	48	79	5	GO:0098703
GeneOntologyBiologicalProcess	calcium ion import into cytosol	SLC8A2 SLC8A3 CACNA1I CACNA1H SLC24A1	1.09e-06	48	79	5	GO:1902656
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	ANO9 CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 SLC39A11 SCN3A OTOP2 FBXO11 CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1 ANO3	1.25e-06	1017	79	16	GO:0098660
GeneOntologyBiologicalProcess	negative regulation of tubulin deacetylation	FRY PRKAA1 PRKAA2	1.87e-06	7	79	3	GO:1904428
GeneOntologyBiologicalProcess	monoatomic ion transport	ANO9 CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 SLC39A11 SCN3A SLC22A15 OTOP2 FBXO11 CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1 PLP2 ANO3	3.33e-06	1374	79	18	GO:0006811
GeneOntologyBiologicalProcess	detection of stimulus	OR1M1 OR4M2 OR51F2 CACNB4 NOD1 OR4M1 OR2C3 OR13G1 OR5M3 GRIN2D ANO3 OR4M2B OR52J3	3.34e-06	722	79	13	GO:0051606
GeneOntologyBiologicalProcess	calcium ion transport	CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 FBXO11 CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1	3.69e-06	509	79	11	GO:0006816
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 SLC39A11 SCN3A OTOP2 FBXO11 CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1	9.54e-06	922	79	14	GO:0098662
GeneOntologyBiologicalProcess	sensory perception	OR1M1 OR4M2 OR51F2 CACNB4 MYO9A OR4M1 OR2C3 OR13G1 FBXO11 OR5M3 GRIN2D SLC24A1 RAB3A OR4M2B OR52J3	1.16e-05	1072	79	15	GO:0007600
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 SLC39A11 SCN3A OTOP2 FBXO11 CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1	1.21e-05	942	79	14	GO:0098655
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR1M1 OR4M2 OR51F2 CACNB4 OR4M1 OR2C3 OR13G1 OR5M3 GRIN2D OR4M2B OR52J3	1.31e-05	582	79	11	GO:0050906
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	SLC8A2 SLC8A3 TRPM5 SCN3A CACNA1I CACNA1H SLC24A1	1.50e-05	208	79	7	GO:0035725
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	SLC8A2 SLC8A3 SLC39A11 CACNA1I CACNA1H SLC24A1	1.76e-05	142	79	6	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	SLC8A2 SLC8A3 SLC39A11 CACNA1I CACNA1H SLC24A1	1.76e-05	142	79	6	GO:0098659
GeneOntologyBiologicalProcess	long-term synaptic potentiation	SLC8A2 SLC8A3 GRIN2C GRIN2D SLC24A1 RAB3A	1.91e-05	144	79	6	GO:0060291
GeneOntologyBiologicalProcess	calcium ion transmembrane import into cytosol	SLC8A2 SLC8A3 CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1	1.98e-05	217	79	7	GO:0097553
GeneOntologyBiologicalProcess	calcium ion import	SLC8A2 SLC8A3 CACNA1I CACNA1H SLC24A1	3.73e-05	98	79	5	GO:0070509
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR1M1 OR4M2 OR51F2 OR4M1 OR2C3 OR13G1 OR5M3 OR4M2B OR52J3	4.02e-05	432	79	9	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR1M1 OR4M2 OR51F2 OR4M1 OR2C3 OR13G1 OR5M3 OR4M2B OR52J3	7.08e-05	465	79	9	GO:0007608
GeneOntologyBiologicalProcess	regulation of tubulin deacetylation	FRY PRKAA1 PRKAA2	7.90e-05	22	79	3	GO:0090043
GeneOntologyBiologicalProcess	putrescine biosynthetic process from ornithine	AZIN2 ODC1	8.65e-05	4	79	2	GO:0033387
GeneOntologyBiologicalProcess	oligosaccharide transport	SLC45A1 SLC45A4	8.65e-05	4	79	2	GO:0015772
GeneOntologyBiologicalProcess	sucrose transport	SLC45A1 SLC45A4	8.65e-05	4	79	2	GO:0015770
GeneOntologyBiologicalProcess	disaccharide transport	SLC45A1 SLC45A4	8.65e-05	4	79	2	GO:0015766
GeneOntologyBiologicalProcess	protein localization to lipid droplet	PRKAA1 PRKAA2	8.65e-05	4	79	2	GO:1990044
GeneOntologyBiologicalProcess	sodium ion transport	SLC8A2 SLC8A3 TRPM5 SCN3A CACNA1I CACNA1H SLC24A1	8.87e-05	275	79	7	GO:0006814
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR1M1 OR4M2 OR51F2 OR4M1 OR2C3 OR13G1 OR5M3 OR4M2B OR52J3	9.76e-05	485	79	9	GO:0050907
GeneOntologyBiologicalProcess	metal ion transport	CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 SLC39A11 SCN3A FBXO11 CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1	1.02e-04	1000	79	13	GO:0030001
GeneOntologyBiologicalProcess	tubulin deacetylation	FRY PRKAA1 PRKAA2	1.03e-04	24	79	3	GO:0090042
GeneOntologyBiologicalProcess	modulation of excitatory postsynaptic potential	SLC8A2 SLC8A3 GRIN2C GRIN2D	1.13e-04	65	79	4	GO:0098815
GeneOntologyBiologicalProcess	monoatomic cation transport	CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 SLC39A11 SCN3A OTOP2 FBXO11 CACNA1I CACNA1H GRIN2C GRIN2D SLC24A1	1.14e-04	1157	79	14	GO:0006812
GeneOntologyBiologicalProcess	regulation of synaptic plasticity	SLC8A2 SLC8A3 UBE3A GRIN2C GRIN2D SLC24A1 RAB3A	1.31e-04	293	79	7	GO:0048167
GeneOntologyBiologicalProcess	calcium activated phospholipid scrambling	ANO9 ANO3	1.44e-04	5	79	2	GO:0061588
GeneOntologyBiologicalProcess	calcium activated phosphatidylcholine scrambling	ANO9 ANO3	1.44e-04	5	79	2	GO:0061590
GeneOntologyBiologicalProcess	calcium activated galactosylceramide scrambling	ANO9 ANO3	1.44e-04	5	79	2	GO:0061591
GeneOntologyBiologicalProcess	dichotomous subdivision of terminal units involved in salivary gland branching	SEMA3C PLXNA1	1.44e-04	5	79	2	GO:0060666
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR1M1 OR4M2 OR51F2 OR4M1 OR2C3 OR13G1 OR5M3 OR4M2B OR52J3	1.75e-04	524	79	9	GO:0009593
GeneOntologyBiologicalProcess	putrescine biosynthetic process	AZIN2 ODC1	2.15e-04	6	79	2	GO:0009446
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR1M1 OR4M2 OR51F2 OR4M1 OR2C3 OR13G1 OR5M3 OR4M2B OR52J3	2.40e-04	547	79	9	GO:0007606
GeneOntologyBiologicalProcess	import across plasma membrane	SLC8A2 SLC8A3 SLC39A11 CACNA1I CACNA1H SLC24A1	2.54e-04	230	79	6	GO:0098739
GeneOntologyBiologicalProcess	positive regulation of synaptic transmission	SLC8A2 SLC8A3 GRIN2C GRIN2D SLC24A1 RAB3A	2.72e-04	233	79	6	GO:0050806
GeneOntologyBiologicalProcess	regulation of membrane potential	ADCY10 SLC8A2 CACNB4 SLC8A3 SCN3A CACNA1I CACNA1H GRIN2C GRIN2D	2.82e-04	559	79	9	GO:0042391
GeneOntologyBiologicalProcess	regulation of neuronal synaptic plasticity	SLC8A2 GRIN2C GRIN2D RAB3A	2.91e-04	83	79	4	GO:0048168
GeneOntologyBiologicalProcess	regulation of protein deacetylation	FRY PRKAA1 PRKAA2	2.97e-04	34	79	3	GO:0090311
GeneOntologyBiologicalProcess	lipid droplet disassembly	PRKAA1 PRKAA2	3.00e-04	7	79	2	GO:1905691
GeneOntologyBiologicalProcess	positive regulation of response to food	OR4M2 OR4M1	3.00e-04	7	79	2	GO:0032097
GeneOntologyBiologicalProcess	positive regulation of appetite	OR4M2 OR4M1	3.00e-04	7	79	2	GO:0032100
GeneOntologyBiologicalProcess	positive regulation of peptidyl-lysine acetylation	PRKAA1 PRKAA2	3.00e-04	7	79	2	GO:2000758
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN3A CACNA1I CACNA1H	3.52e-04	36	79	3	GO:0086010
GeneOntologyBiologicalProcess	positive regulation of response to nutrient levels	OR4M2 OR4M1	4.00e-04	8	79	2	GO:0032109
GeneOntologyBiologicalProcess	negative regulation of hepatocyte apoptotic process	PRKAA1 PRKAA2	4.00e-04	8	79	2	GO:1903944
GeneOntologyBiologicalProcess	putrescine metabolic process	AZIN2 ODC1	5.12e-04	9	79	2	GO:0009445
GeneOntologyBiologicalProcess	calcium ion transport into cytosol	SLC8A2 SLC8A3 CACNA1I	5.57e-04	42	79	3	GO:0060402
GeneOntologyBiologicalProcess	regulation of calcium ion-dependent exocytosis	CACNA1I CACNA1H RAB3A	6.83e-04	45	79	3	GO:0017158
GeneOntologyBiologicalProcess	acrosome reaction	CACNA1H SERPINA10 RAB3A	7.77e-04	47	79	3	GO:0007340
GeneOntologyBiologicalProcess	protein deacetylation	FRY PRKAA1 PRKAA2	7.77e-04	47	79	3	GO:0006476
GeneOntologyBiologicalProcess	dichotomous subdivision of an epithelial terminal unit	SEMA3C PLXNA1	7.79e-04	11	79	2	GO:0060600
GeneOntologyBiologicalProcess	regulation of hepatocyte apoptotic process	PRKAA1 PRKAA2	7.79e-04	11	79	2	GO:1903943
GeneOntologyBiologicalProcess	positive regulation of ATP metabolic process	ADCY10 PRKAA1 PRKAA2	8.26e-04	48	79	3	GO:1903580
GeneOntologyBiologicalProcess	transmission of nerve impulse	CACNB4 SCN3A CACNA1I CACNA1H	9.05e-04	112	79	4	GO:0019226
GeneOntologyBiologicalProcess	regulation of stress granule assembly	PRKAA1 PRKAA2	9.32e-04	12	79	2	GO:0062028
GeneOntologyBiologicalProcess	calcium ion export across plasma membrane	SLC8A2 SLC8A3	9.32e-04	12	79	2	GO:1990034
GeneOntologyBiologicalProcess	ornithine metabolic process	AZIN2 ODC1	9.32e-04	12	79	2	GO:0006591
GeneOntologyBiologicalProcess	regulation of peptidyl-lysine acetylation	PRKAA1 PRKAA2	9.32e-04	12	79	2	GO:2000756
GeneOntologyBiologicalProcess	negative regulation of TORC1 signaling	UBE3A PRKAA1 PRKAA2	1.04e-03	52	79	3	GO:1904262
GeneOntologyBiologicalProcess	action potential	SLC8A2 CACNB4 SCN3A CACNA1I CACNA1H	1.05e-03	201	79	5	GO:0001508
GeneOntologyBiologicalProcess	membrane depolarization	ADCY10 SCN3A CACNA1I CACNA1H	1.21e-03	121	79	4	GO:0051899
GeneOntologyBiologicalProcess	positive regulation of nucleotide metabolic process	ADCY10 PRKAA1 PRKAA2	1.23e-03	55	79	3	GO:0045981
GeneOntologyBiologicalProcess	positive regulation of purine nucleotide metabolic process	ADCY10 PRKAA1 PRKAA2	1.23e-03	55	79	3	GO:1900544
GeneOntologyBiologicalProcess	protein deacylation	FRY PRKAA1 PRKAA2	1.43e-03	58	79	3	GO:0035601
GeneOntologyBiologicalProcess	polyamine biosynthetic process	AZIN2 ODC1	1.47e-03	15	79	2	GO:0006596
GeneOntologyBiologicalProcess	excitatory postsynaptic potential	SLC8A2 SLC8A3 GRIN2C GRIN2D	1.57e-03	130	79	4	GO:0060079
GeneOntologyBiologicalProcess	cellular response to prostaglandin E stimulus	PRKAA1 PRKAA2	1.68e-03	16	79	2	GO:0071380
GeneOntologyBiologicalProcess	excitatory chemical synaptic transmission	GRIN2C GRIN2D	1.68e-03	16	79	2	GO:0098976
GeneOntologyBiologicalProcess	macromolecule deacylation	FRY PRKAA1 PRKAA2	1.82e-03	63	79	3	GO:0098732
GeneOntologyBiologicalProcess	neuronal action potential	SCN3A CACNA1I CACNA1H	1.82e-03	63	79	3	GO:0019228
GeneOntologyBiologicalProcess	regulation of exocytosis	CACNB4 CACNA1I CACNA1H RAB3A RAB3B	2.01e-03	233	79	5	GO:0017157
GeneOntologyBiologicalProcess	positive regulation of regulated secretory pathway	CACNA1I CACNA1H RAB3A	2.08e-03	66	79	3	GO:1903307
GeneOntologyBiologicalProcess	positive regulation of cilium-dependent cell motility	OR4M2 OR4M1	2.13e-03	18	79	2	GO:2000155
GeneOntologyBiologicalProcess	positive regulation of flagellated sperm motility	OR4M2 OR4M1	2.13e-03	18	79	2	GO:1902093
GeneOntologyBiologicalProcess	positive regulation of protein acetylation	PRKAA1 PRKAA2	2.13e-03	18	79	2	GO:1901985
GeneOntologyBiologicalProcess	fatty acid homeostasis	PRKAA1 PRKAA2	2.13e-03	18	79	2	GO:0055089
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNB1 CACNB4 CACNA1I CACNA1H	2.73e-05	46	79	4	GO:0005891
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN3A CACNA1I CACNA1H	3.40e-05	17	79	3	GO:0001518
GeneOntologyCellularComponent	monoatomic ion channel complex	CACNB1 CACNB4 TRPM5 SCN3A CACNA1I CACNA1H GRIN2C GRIN2D	9.05e-05	378	79	8	GO:0034702
GeneOntologyCellularComponent	calcium channel complex	CACNB1 CACNB4 CACNA1I CACNA1H	1.69e-04	73	79	4	GO:0034704
GeneOntologyCellularComponent	sodium channel complex	SCN3A CACNA1I CACNA1H	1.77e-04	29	79	3	GO:0034706
GeneOntologyCellularComponent	NMDA selective glutamate receptor complex	GRIN2C GRIN2D	4.99e-04	9	79	2	GO:0017146
GeneOntologyCellularComponent	nucleotide-activated protein kinase complex	PRKAA1 PRKAA2	7.59e-04	11	79	2	GO:0031588
GeneOntologyCellularComponent	transmembrane transporter complex	CACNB1 CACNB4 TRPM5 SCN3A CACNA1I CACNA1H GRIN2C GRIN2D	8.00e-04	523	79	8	GO:1902495
GeneOntologyCellularComponent	transporter complex	CACNB1 CACNB4 TRPM5 SCN3A CACNA1I CACNA1H GRIN2C GRIN2D	1.11e-03	550	79	8	GO:1990351
GeneOntologyCellularComponent	neuronal cell body	ADCY10 SLC8A2 SLC8A3 TRPM5 AZIN2 SCN3A PRKAA1 PRKAA2 CACNA1H SLC24A1	1.17e-03	835	79	10	GO:0043025
GeneOntologyCellularComponent	axon	ADCY10 SLC8A2 SLC8A3 MYO9A AZIN2 SCN3A PRKAA1 PRKAA2 CBL RAB3A	1.89e-03	891	79	10	GO:0030424
GeneOntologyCellularComponent	cation channel complex	CACNB1 CACNB4 SCN3A CACNA1I CACNA1H	1.97e-03	235	79	5	GO:0034703
GeneOntologyCellularComponent	cell body	ADCY10 SLC8A2 SLC8A3 TRPM5 AZIN2 SCN3A PRKAA1 PRKAA2 CACNA1H SLC24A1	2.56e-03	929	79	10	GO:0044297
GeneOntologyCellularComponent	plasma membrane protein complex	CACNB1 CACNB4 SCN3A DUOX2 CACNA1I CACNA1H GRIN2C GRIN2D CBL	2.79e-03	785	79	9	GO:0098797
Domain	NaCa_Exmemb	SLC8A2 SLC8A3 SLC24A1	5.56e-06	9	77	3	IPR004837
Domain	Na_Ca_ex	SLC8A2 SLC8A3 SLC24A1	5.56e-06	9	77	3	PF01699
Domain	AMPK_C	PRKAA1 PRKAA2	1.68e-05	2	77	2	IPR032270
Domain	De-COase2_pyr-phos_BS	AZIN2 ODC1	1.68e-05	2	77	2	IPR022653
Domain	AdenylateSensor	PRKAA1 PRKAA2	1.68e-05	2	77	2	PF16579
Domain	P-loop_NTPase	ADCY10 CACNB1 CACNB4 NOD1 DDX17 MYO9A MOV10L1 DDX42 BMS1 DDX3Y RAB3A RAB3B SNRNP200	3.95e-05	848	77	13	IPR027417
Domain	Orn_de-COase	AZIN2 ODC1	5.02e-05	3	77	2	IPR002433
Domain	-	AZIN2 ODC1	5.02e-05	3	77	2	2.40.37.10
Domain	Na_Ca_Ex	SLC8A2 SLC8A3	5.02e-05	3	77	2	IPR004836
Domain	Ala_racemase/Decarboxylase_C	AZIN2 ODC1	5.02e-05	3	77	2	IPR009006
Domain	Orn_Arg_deC_N	AZIN2 ODC1	5.02e-05	3	77	2	PF02784
Domain	Na_Ca_Ex_C-exten	SLC8A2 SLC8A3	5.02e-05	3	77	2	IPR032452
Domain	De-COase2_CS	AZIN2 ODC1	5.02e-05	3	77	2	IPR022657
Domain	De-COase2_N	AZIN2 ODC1	5.02e-05	3	77	2	IPR022644
Domain	De-COase2_C	AZIN2 ODC1	5.02e-05	3	77	2	IPR022643
Domain	ODR_DC_2_1	AZIN2 ODC1	5.02e-05	3	77	2	PS00878
Domain	ODR_DC_2_2	AZIN2 ODC1	5.02e-05	3	77	2	PS00879
Domain	Orn_DAP_Arg_deC	AZIN2 ODC1	5.02e-05	3	77	2	PF00278
Domain	VDCC_T_a1	CACNA1I CACNA1H	5.02e-05	3	77	2	IPR005445
Domain	Na_Ca_ex_C	SLC8A2 SLC8A3	5.02e-05	3	77	2	PF16494
Domain	Orn/DAP/Arg_de-COase	AZIN2 ODC1	5.02e-05	3	77	2	IPR000183
Domain	-	ADCY10 CACNB1 CACNB4 NOD1 DDX17 MOV10L1 DDX42 BMS1 DDX3Y RAB3A RAB3B SNRNP200	5.11e-05	746	77	12	3.40.50.300
Domain	VDCC_L_bsu	CACNB1 CACNB4	1.00e-04	4	77	2	IPR000584
Domain	-	AZIN2 ODC1	1.00e-04	4	77	2	3.20.20.10
Domain	PLP-binding_barrel	AZIN2 ODC1	1.00e-04	4	77	2	IPR029066
Domain	VGCC_beta4Aa_N	CACNB1 CACNB4	1.00e-04	4	77	2	PF12052
Domain	Olfact_rcpt	OR1M1 OR4M2 OR51F2 OR4M1 OR2C3 OR13G1 OR5M3 OR52J3	2.12e-04	393	77	8	IPR000725
Domain	DEAD/DEAH_box_helicase_dom	DDX17 DDX42 DDX3Y SNRNP200	2.34e-04	73	77	4	IPR011545
Domain	DEAD	DDX17 DDX42 DDX3Y SNRNP200	2.34e-04	73	77	4	PF00270
Domain	DEAD_ATP_HELICASE	DDX17 DDX42 DDX3Y	2.79e-04	31	77	3	PS00039
Domain	RNA-helicase_DEAD-box_CS	DDX17 DDX42 DDX3Y	3.36e-04	33	77	3	IPR000629
Domain	KA1/Ssp2_C	PRKAA1 PRKAA2	3.48e-04	7	77	2	IPR028375
Domain	TPR-like_helical_dom	ADCY10 LRPPRC TRAPPC10 CSTF3 CABIN1 TRRAP	4.00e-04	233	77	6	IPR011990
Domain	Calx_beta	SLC8A2 SLC8A3	4.62e-04	8	77	2	SM00237
Domain	Q_MOTIF	DDX17 DDX42 DDX3Y	4.73e-04	37	77	3	PS51195
Domain	RNA_helicase_DEAD_Q_motif	DDX17 DDX42 DDX3Y	4.73e-04	37	77	3	IPR014014
Domain	Calx_beta	SLC8A2 SLC8A3	5.93e-04	9	77	2	IPR003644
Domain	Calx-beta	SLC8A2 SLC8A3	5.93e-04	9	77	2	PF03160
Domain	Anoctamin	ANO9 ANO3	7.39e-04	10	77	2	PF04547
Domain	Anoctamin	ANO9 ANO3	7.39e-04	10	77	2	IPR007632
Domain	VDCCAlpha1	CACNA1I CACNA1H	7.39e-04	10	77	2	IPR002077
Domain	Helicase_C	DDX17 DDX42 DDX3Y SNRNP200	9.99e-04	107	77	4	PF00271
Domain	HELICc	DDX17 DDX42 DDX3Y SNRNP200	9.99e-04	107	77	4	SM00490
Domain	Helicase_C	DDX17 DDX42 DDX3Y SNRNP200	1.03e-03	108	77	4	IPR001650
Domain	HELICASE_CTER	DDX17 DDX42 DDX3Y SNRNP200	1.07e-03	109	77	4	PS51194
Domain	HELICASE_ATP_BIND_1	DDX17 DDX42 DDX3Y SNRNP200	1.07e-03	109	77	4	PS51192
Domain	DEXDc	DDX17 DDX42 DDX3Y SNRNP200	1.07e-03	109	77	4	SM00487
Domain	Helicase_ATP-bd	DDX17 DDX42 DDX3Y SNRNP200	1.11e-03	110	77	4	IPR014001
Domain	Ion_trans_dom	TRPM5 SCN3A CACNA1I CACNA1H	1.26e-03	114	77	4	IPR005821
Domain	Ion_trans	TRPM5 SCN3A CACNA1I CACNA1H	1.26e-03	114	77	4	PF00520
Domain	-	ADCY10 LRPPRC CSTF3 CABIN1 TRRAP	1.65e-03	207	77	5	1.25.40.10
Domain	Channel_four-helix_dom	SCN3A CACNA1I CACNA1H	1.68e-03	57	77	3	IPR027359
Domain	-	SCN3A CACNA1I CACNA1H	1.68e-03	57	77	3	1.20.120.350
Domain	Iontro_rcpt	GRIN2C GRIN2D	2.46e-03	18	77	2	IPR001320
Domain	Lig_chan-Glu_bd	GRIN2C GRIN2D	2.46e-03	18	77	2	PF10613
Domain	Iono_rcpt_met	GRIN2C GRIN2D	2.46e-03	18	77	2	IPR001508
Domain	Glu/Gly-bd	GRIN2C GRIN2D	2.46e-03	18	77	2	IPR019594
Domain	Lig_chan-Glu_bd	GRIN2C GRIN2D	2.46e-03	18	77	2	SM00918
Domain	Lig_chan	GRIN2C GRIN2D	2.46e-03	18	77	2	PF00060
Domain	PBPe	GRIN2C GRIN2D	2.46e-03	18	77	2	SM00079
Pathway	WP_SYNAPTIC_SIGNALING_ASSOCIATED_WITH_AUTISM_SPECTRUM_DISORDER	UBE3A PRKAA1 PRKAA2 GRIN2C GRIN2D	3.47e-06	50	66	5	M39822
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNB1 CACNB4 CACNA1I CACNA1H	5.15e-06	25	66	4	M47948
Pathway	REACTOME_SODIUM_CALCIUM_EXCHANGERS	SLC8A2 SLC8A3 SLC24A1	1.57e-05	11	66	3	M27336
Pathway	REACTOME_SODIUM_CALCIUM_EXCHANGERS	SLC8A2 SLC8A3 SLC24A1	2.71e-05	13	66	3	MM15078
Pathway	REACTOME_SENSORY_PERCEPTION	OR1M1 OR4M2 OR51F2 TRPM5 SCN3A OR4M1 OR2C3 OR13G1 OR5M3 SLC24A1 RAB3A OR52J3	3.37e-05	636	66	12	M41834
Pathway	REACTOME_NCAM1_INTERACTIONS	CACNB1 CACNB4 CACNA1I CACNA1H	4.29e-05	42	66	4	M7169
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	SLC8A2 SLC8A3 CACNA1I CACNA1H GRIN2C GRIN2D	1.81e-04	178	66	6	M2890
Pathway	WP_THYROXINE_THYROID_HORMONE_PRODUCTION	PRKAA1 PRKAA2 DUOX2	2.09e-04	25	66	3	M39353
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	CACNB1 CACNB4 CACNA1I CACNA1H	2.12e-04	63	66	4	M11187
Pathway	KEGG_MEDICUS_REFERENCE_TRANSPORT_OF_CALCIUM	GRIN2C GRIN2D	2.14e-04	5	66	2	M47667
Pathway	REACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS	GRIN2C GRIN2D	2.14e-04	5	66	2	MM15655
Pathway	REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	CACNB1 CACNB4 PRKAA1 PRKAA2 GRIN2C GRIN2D RAB3A	2.60e-04	270	66	7	M15514
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PDYN_TO_TRANSPORT_OF_CALCIUM	GRIN2C GRIN2D	3.20e-04	6	66	2	M47668
Pathway	REACTOME_MUSCLE_CONTRACTION	CACNB1 SLC8A2 SLC8A3 SCN3A CACNA1I CACNA1H	3.67e-04	203	66	6	M5485
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR1M1 OR4M2 OR51F2 OR4M1 OR2C3 OR13G1 OR5M3 OR52J3	4.44e-04	389	66	8	M14091
Pathway	KEGG_MEDICUS_REFERENCE_STRAD_STK11_TSC_SIGNALING_PATHWAY	PRKAA1 PRKAA2	5.94e-04	8	66	2	M47916
Pathway	KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM	CACNB1 CACNB4 PRKAA1 PRKAA2	6.10e-04	83	66	4	M8728
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR1M1 OR4M2 OR51F2 OR4M1 OR2C3 OR13G1 OR5M3 OR52J3	7.01e-04	417	66	8	M4072
Pathway	REACTOME_ACTIVATION_OF_PPARGC1A_PGC_1ALPHA_BY_PHOSPHORYLATION	MAPK12 PRKAA2	9.48e-04	10	66	2	M27146
Pathway	REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS	PRKAA1 PRKAA2 GRIN2C GRIN2D	9.74e-04	94	66	4	M2843
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNB1 CACNB4	1.16e-03	11	66	2	MM14498
Pathway	BIOCARTA_LEPTIN_PATHWAY	PRKAA1 PRKAA2	1.16e-03	11	66	2	M18053
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNB1 CACNB4	1.16e-03	11	66	2	M26913
Pathway	REACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS	SLC8A2 SLC8A3	1.38e-03	12	66	2	M27326
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_LIGAND_GATED_CA2_CHANNEL	GRIN2C GRIN2D	1.38e-03	12	66	2	M47953
Pathway	REACTOME_INDUCTION_OF_CELL_CELL_FUSION	ANO9 ANO3	1.63e-03	13	66	2	M46426
Pathway	WP_THERMOGENESIS	ADCY10 MAPK12 PRKAA1 PRKAA2	1.63e-03	108	66	4	M39746
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNB1 SLC8A2 CACNB4 SLC8A3 CACNA1I	2.52e-08	38	79	5	30786075
Pubmed	Sodium/calcium exchanger expression in the mouse and rat olfactory systems.	SLC8A2 SLC8A3 SLC24A1	2.24e-07	6	79	3	17311327
Pubmed	Mono-ubiquitination of Rabphilin 3A by UBE3A serves a non-degradative function.	UBE3A RAB3A RAB3B	3.92e-07	7	79	3	33542309
Pubmed	NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.	CACNB1 CACNB4 CACNA1H	1.84e-06	11	79	3	18809727
Pubmed	DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.	LRPPRC XRN2 DDX17 CSTF3 SNRNP200	1.90e-06	89	79	5	22446626
Pubmed	Preferential involvement of Na⁺/Ca²⁺ exchanger type-1 in the brain damage caused by transient focal cerebral ischemia in mice.	SLC8A2 SLC8A3	5.09e-06	2	79	2	23137542
Pubmed	Nitric oxide-induced activation of the AMP-activated protein kinase α2 subunit attenuates IκB kinase activity and inflammatory responses in endothelial cells.	PRKAA1 PRKAA2	5.09e-06	2	79	2	21673972
Pubmed	Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans.	PRKAA1 PRKAA2	5.09e-06	2	79	2	18801964
Pubmed	Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status.	PRKAA1 PRKAA2	5.09e-06	2	79	2	21947382
Pubmed	Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation.	PRKAA1 PRKAA2	5.09e-06	2	79	2	32839348
Pubmed	Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.	PRKAA1 PRKAA2	5.09e-06	2	79	2	20465544
Pubmed	A T-type calcium channel required for normal function of a mammalian mechanoreceptor.	CACNA1I CACNA1H	5.09e-06	2	79	2	12808460
Pubmed	In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons.	GRIN2C GRIN2D	5.09e-06	2	79	2	29651654
Pubmed	AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside.	PRKAA1 PRKAA2	5.09e-06	2	79	2	17324122
Pubmed	Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase.	PRKAA1 PRKAA2	5.09e-06	2	79	2	19236843
Pubmed	Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.	PRKAA1 PRKAA2	5.09e-06	2	79	2	23905686
Pubmed	Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes.	GRIN2C GRIN2D	5.09e-06	2	79	2	31110197
Pubmed	Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase α2.	PRKAA1 PRKAA2	5.09e-06	2	79	2	24420540
Pubmed	Na+/Ca2+ exchanger mediates cold Ca2+ signaling conserved for temperature-compensated circadian rhythms.	SLC8A2 SLC8A3	5.09e-06	2	79	2	33931447
Pubmed	Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease.	AZIN2 ODC1	5.09e-06	2	79	2	19832840
Pubmed	Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise.	PRKAA1 PRKAA2	5.09e-06	2	79	2	32504885
Pubmed	Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK.	PRKAA1 PRKAA2	5.09e-06	2	79	2	38657612
Pubmed	Coordinated maintenance of muscle cell size control by AMP-activated protein kinase.	PRKAA1 PRKAA2	5.09e-06	2	79	2	20460585
Pubmed	Adipose tissue-specific knockout of AMPKα1/α2 results in normal AICAR tolerance and glucose metabolism.	PRKAA1 PRKAA2	5.09e-06	2	79	2	31540695
Pubmed	Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice.	CACNA1I CACNA1H	5.09e-06	2	79	2	25071191
Pubmed	Functional differences between AMPK α1 and α2 subunits in osteogenesis, osteoblast-associated induction of osteoclastogenesis, and adipogenesis.	PRKAA1 PRKAA2	5.09e-06	2	79	2	27600021
Pubmed	Compound C inhibits hypoxic activation of HIF-1 independent of AMPK.	PRKAA1 PRKAA2	5.09e-06	2	79	2	18036344
Pubmed	Genetic deletion of catalytic subunits of AMP-activated protein kinase increases osteoclasts and reduces bone mass in young adult mice.	PRKAA1 PRKAA2	5.09e-06	2	79	2	23486478
Pubmed	Endothelial AMP-Activated Kinase α1 Phosphorylates eNOS on Thr495 and Decreases Endothelial NO Formation.	PRKAA1 PRKAA2	5.09e-06	2	79	2	30217073
Pubmed	Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle.	PRKAA1 PRKAA2	5.09e-06	2	79	2	15878932
Pubmed	Susceptibility to ATP depletion of primary proximal tubular cell cultures derived from mice lacking either the α1 or the α2 isoform of the catalytic domain of AMPK.	PRKAA1 PRKAA2	5.09e-06	2	79	2	24228806
Pubmed	Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell.	PRKAA1 PRKAA2	5.09e-06	2	79	2	21506122
Pubmed	AMPK activation regulates neuronal structure in developing hippocampal neurons.	PRKAA1 PRKAA2	5.09e-06	2	79	2	24295634
Pubmed	Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction.	PRKAA1 PRKAA2	5.09e-06	2	79	2	27052588
Pubmed	Specific deletion of AMP-activated protein kinase (α1AMPK) in murine oocytes alters junctional protein expression and mitochondrial physiology.	PRKAA1 PRKAA2	5.09e-06	2	79	2	25767884
Pubmed	AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function.	PRKAA1 PRKAA2	5.09e-06	2	79	2	18350549
Pubmed	Whole Exome Sequencing of Hemiplegic Migraine Patients Shows an Increased Burden of Missense Variants in CACNA1H and CACNA1I Genes.	CACNA1I CACNA1H	5.09e-06	2	79	2	36786913
Pubmed	Loss of AMPK activity induces organelle dysfunction and oxidative stress during oocyte aging.	PRKAA1 PRKAA2	5.09e-06	2	79	2	38654312
Pubmed	AMP kinase regulation of sugar transport in brain capillary endothelial cells during acute metabolic stress.	PRKAA1 PRKAA2	5.09e-06	2	79	2	22763120
Pubmed	Activation of AMP kinase alpha1 subunit induces aortic vasorelaxation in mice.	PRKAA1 PRKAA2	5.09e-06	2	79	2	17446219
Pubmed	5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) effect on glucose production, but not energy metabolism, is independent of hepatic AMPK in vivo.	PRKAA1 PRKAA2	5.09e-06	2	79	2	24403081
Pubmed	AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase.	PRKAA1 PRKAA2	5.09e-06	2	79	2	22233421
Pubmed	Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.	PRKAA1 PRKAA2	5.09e-06	2	79	2	14573616
Pubmed	Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice.	GRIN2C GRIN2D	5.09e-06	2	79	2	35057644
Pubmed	Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism.	SLC8A2 SLC8A3	5.09e-06	2	79	2	19667209
Pubmed	The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint.	PRKAA1 PRKAA2	5.09e-06	2	79	2	26843621
Pubmed	Phosphorylation and activation of AMP-activated protein kinase (AMPK) by metformin in the human ovary requires insulin.	PRKAA1 PRKAA2	5.09e-06	2	79	2	21209024
Pubmed	Endothelial AMP-activated protein kinase regulates blood pressure and coronary flow responses through hyperpolarization mechanism in mice.	PRKAA1 PRKAA2	5.09e-06	2	79	2	24855056
Pubmed	AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle.	PRKAA1 PRKAA2	5.09e-06	2	79	2	26419588
Pubmed	AMP activated protein kinase is indispensable for myocardial adaptation to caloric restriction in mice.	PRKAA1 PRKAA2	5.09e-06	2	79	2	23527250
Pubmed	Autophagy and mitochondrial biogenesis impairment contribute to age-dependent liver injury in experimental sepsis: dysregulation of AMP-activated protein kinase pathway.	PRKAA1 PRKAA2	5.09e-06	2	79	2	28974562
Pubmed	Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models.	PRKAA1 PRKAA2	5.09e-06	2	79	2	12546688
Pubmed	Polarized activities of AMPK and BRSK in primary hippocampal neurons.	PRKAA1 PRKAA2	5.09e-06	2	79	2	25788287
Pubmed	AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress.	PRKAA1 PRKAA2	5.09e-06	2	79	2	12788940
Pubmed	Skeletal muscle-specific inducible AMPKα1/α2 knockout mice develop muscle weakness, glycogen depletion, and fibrosis that persists during disuse atrophy.	PRKAA1 PRKAA2	5.09e-06	2	79	2	38019084
Pubmed	Structures of the murine genes for the beta1- and beta4-subunits of the voltage-dependent calcium channel.	CACNB1 CACNB4	5.09e-06	2	79	2	14500989
Pubmed	NMDA receptors containing GluN2C and GluN2D subunits have opposing roles in modulating neuronal oscillations; potential mechanism for bidirectional feedback.	GRIN2C GRIN2D	5.09e-06	2	79	2	31786200
Pubmed	The AMP-dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma.	PRKAA1 PRKAA2	5.09e-06	2	79	2	34347929
Pubmed	Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal.	PRKAA1 PRKAA2	5.09e-06	2	79	2	29610348
Pubmed	Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.	PRKAA1 PRKAA2	5.09e-06	2	79	2	19268526
Pubmed	Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK.	PRKAA1 PRKAA2	5.09e-06	2	79	2	31693892
Pubmed	Metabolic regulation of neuronal plasticity by the energy sensor AMPK.	PRKAA1 PRKAA2	5.09e-06	2	79	2	20126541
Pubmed	Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer's model mice.	PRKAA1 PRKAA2	5.09e-06	2	79	2	32213711
Pubmed	AMPK knockdown in placental trophoblast cells results in altered morphology and function.	PRKAA1 PRKAA2	5.09e-06	2	79	2	25003940
Pubmed	AMPK-α1 or AMPK-α2 Deletion in Smooth Muscles Does Not Affect the Hypoxic Ventilatory Response or Systemic Arterial Blood Pressure Regulation During Hypoxia.	PRKAA1 PRKAA2	5.09e-06	2	79	2	29928235
Pubmed	AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death.	PRKAA1 PRKAA2	5.09e-06	2	79	2	36028487
Pubmed	AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice.	PRKAA1 PRKAA2	5.09e-06	2	79	2	25609422
Pubmed	[AMPK as a Metabolic Intersection between Diet and Physical Exercise].	PRKAA1 PRKAA2	5.09e-06	2	79	2	30270274
Pubmed	AMPK α2 subunit is involved in platelet signaling, clot retraction, and thrombus stability.	PRKAA1 PRKAA2	5.09e-06	2	79	2	20558612
Pubmed	Inhibition of AMP-activated protein kinase accentuates lipopolysaccharide-induced lung endothelial barrier dysfunction and lung injury in vivo.	PRKAA1 PRKAA2	5.09e-06	2	79	2	23306156
Pubmed	AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.	PRKAA1 PRKAA2	5.09e-06	2	79	2	28225087
Pubmed	AMPK regulates circadian rhythms in a tissue- and isoform-specific manner.	PRKAA1 PRKAA2	5.09e-06	2	79	2	21483791
Pubmed	AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass.	PRKAA1 PRKAA2	5.09e-06	2	79	2	20399918
Pubmed	Conditional disruption of AMP kinase in dopaminergic neurons promotes Parkinson's disease-associated phenotypes in vivo.	PRKAA1 PRKAA2	5.09e-06	2	79	2	34767944
Pubmed	Involvement of AMPK in regulating slow-twitch muscle atrophy during hindlimb unloading in mice.	PRKAA1 PRKAA2	5.09e-06	2	79	2	26244519
Pubmed	Stimulation of glucose transport in response to activation of distinct AMPK signaling pathways.	PRKAA1 PRKAA2	5.09e-06	2	79	2	18701654
Pubmed	Hypoxia and nitric oxide treatment confer tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent manner.	PRKAA1 PRKAA2	5.09e-06	2	79	2	12091379
Pubmed	A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators.	PRKAA1 PRKAA2	5.09e-06	2	79	2	24665903
Pubmed	Role of AMPK throughout meiotic maturation in the mouse oocyte: evidence for promotion of polar body formation and suppression of premature activation.	PRKAA1 PRKAA2	5.09e-06	2	79	2	20830737
Pubmed	AMPKalpha1 deletion shortens erythrocyte life span in mice: role of oxidative stress.	PRKAA1 PRKAA2	5.09e-06	2	79	2	20392689
Pubmed	Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility.	GRIN2C GRIN2D	5.09e-06	2	79	2	29317596
Pubmed	CCCP induces autophagy in an AMPK-independent manner.	PRKAA1 PRKAA2	5.09e-06	2	79	2	22119190
Pubmed	AMP-Activated Protein Kinase (AMPK) Regulates Energy Metabolism through Modulating Thermogenesis in Adipose Tissue.	PRKAA1 PRKAA2	5.09e-06	2	79	2	29515462
Pubmed	Protein expression alteration in hippocampus upon genetic repression of AMPKα isoforms.	PRKAA1 PRKAA2	5.09e-06	2	79	2	33492732
Pubmed	Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice.	PRKAA1 PRKAA2	5.09e-06	2	79	2	29038293
Pubmed	Different expression of the catalytic alpha subunits of the AMP activated protein kinase--an immunohistochemical study in human tissue.	PRKAA1 PRKAA2	5.09e-06	2	79	2	21432774
Pubmed	Glucose availability but not changes in pancreatic hormones sensitizes hepatic AMPK activity during nutritional transition in rodents.	PRKAA1 PRKAA2	5.09e-06	2	79	2	32184359
Pubmed	alpha2 But not alpha1 AMP-activated protein kinase mediates oxidative stress-induced inhibition of retinal pigment epithelium cell phagocytosis of photoreceptor outer segments.	PRKAA1 PRKAA2	5.09e-06	2	79	2	18195011
Pubmed	AMP-activated protein kinase alpha2 activity is not essential for contraction- and hyperosmolarity-induced glucose transport in skeletal muscle.	PRKAA1 PRKAA2	5.09e-06	2	79	2	16186119
Pubmed	Role of adenosine 5'-monophosphate-activated protein kinase in α-linolenic acid-induced intestinal lipid metabolism.	PRKAA1 PRKAA2	5.09e-06	2	79	2	26268732
Pubmed	AMP-activated protein kinase mediates effects of oxidative stress on embryo gene expression in a mouse model of diabetic embryopathy.	PRKAA1 PRKAA2	5.09e-06	2	79	2	21993711
Pubmed	Kidney-specific genetic deletion of both AMPK α-subunits causes salt and water wasting.	PRKAA1 PRKAA2	5.09e-06	2	79	2	28179232
Pubmed	Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity.	AZIN2 ODC1	5.09e-06	2	79	2	16916800
Pubmed	The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease.	SLC8A2 SLC8A3	5.09e-06	2	79	2	23224884
Pubmed	NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice.	GRIN2C GRIN2D	5.09e-06	2	79	2	33766086
Pubmed	5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation.	PRKAA1 PRKAA2	5.09e-06	2	79	2	16567505
Pubmed	AMP-activated Kinase (AMPK) Promotes Innate Immunity and Antiviral Defense through Modulation of Stimulator of Interferon Genes (STING) Signaling.	PRKAA1 PRKAA2	5.09e-06	2	79	2	27879319
Pubmed	Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity.	PRKAA1 PRKAA2	5.09e-06	2	79	2	19486896
Pubmed	Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation.	PRKAA1 PRKAA2	5.09e-06	2	79	2	28107516
Pubmed	AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity.	PRKAA1 PRKAA2	5.09e-06	2	79	2	24652947
GeneFamily	Calcium voltage-gated channel subunits	CACNB1 CACNB4 CACNA1I CACNA1H	1.01e-06	26	54	4	253
GeneFamily	Solute carriers	SLC8A2 SLC8A3 SLC39A11 SLC22A15 SLC19A3 SLC45A1 SLC24A1 SLC45A4	2.09e-05	395	54	8	752
GeneFamily	Glutamate ionotropic receptor NMDA type subunits	GRIN2C GRIN2D	1.82e-04	7	54	2	1201
GeneFamily	DEAD-box helicases	DDX17 DDX42 DDX3Y	2.66e-04	42	54	3	499
GeneFamily	Anoctamins	ANO9 ANO3	3.88e-04	10	54	2	865
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	CACNB1 CACNB4	2.72e-03	26	54	2	904
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	DDX3Y SSR1	1.02e-02	51	54	2	870
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC8A2 RASAL3 AZIN2 CCDC80 PLXNA1	1.49e-05	177	78	5	30f82b04e48940bfcaf2c22677efe6d57ae3f1a7
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ENPP6 CDC42BPA CCDC80 IRF6 SLC45A4	1.70e-05	182	78	5	c7f2d24697affa530b748ab32b1d40bdc1bdc20a
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ENPP6 CDC42BPA CCDC80 IRF6 SLC45A4	1.70e-05	182	78	5	d95635b74e8cd8bc00bfe40340806b59fb9bee43
ToppCell	facs-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENPP6 CDC42BPA CCDC80 IRF6 SLC45A4	1.75e-05	183	78	5	12e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell	PND07-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN3A CACNA1H SLC45A1 RAB3B PLXNA1	1.80e-05	184	78	5	3e5c68a99c10eb1ddc1048bea4aa9f6b8e2746ff
ToppCell	PND07-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN3A CACNA1H SLC45A1 RAB3B PLXNA1	1.80e-05	184	78	5	1e2f0cec50475a1cf2973a5082826bbc60fc9a68
ToppCell	Striatum-Neuronal-Excitatory\|Striatum / BrainAtlas - Mouse McCarroll V32	CACNB1 SLC8A2 CACNB4 SCN3A ANO3	2.43e-05	196	78	5	67400193ba469cf4d939e94f5ed94995e384bc07
ToppCell	NS-critical-d_07-13\|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SEMA3C CDC42BPA DUOX2 DDX3Y CCDC80	2.55e-05	198	78	5	a6e11c87b31beffb6af190c64b4ef3ee1d9dab8d
Computational	Neighborhood of DDB1	LRPPRC BMS1 NELFB CSTF3 SSR1 TRRAP SNRNP200	4.81e-05	246	43	7	MORF_DDB1
Computational	Neighborhood of PRKAG1	LRPPRC BMS1 NELFB CSTF3 SSR1 SNRNP200	2.45e-04	224	43	6	MORF_PRKAG1
Drug	bepridil	CACNB1 SLC8A2 CACNB4 SLC8A3 SCN3A CACNA1I CACNA1H SLC24A1	1.07e-08	126	77	8	CID000002351
Drug	Mibefradil	CACNB1 CACNB4 CACNA1I CACNA1H	3.92e-08	11	77	4	DB01388
Drug	lamotrigine	CACNB1 CACNB4 SCN3A CACNA1I CACNA1H GRIN2C GRIN2D	1.33e-07	116	77	7	CID000003878
Drug	Dantrolene-13C3	CACNB1 CACNB4 CACNA1I CACNA1H NUP214 GRIN2C GRIN2D	6.09e-07	145	77	7	CID000002951
Drug	loperamide	CACNB1 CACNB4 CACNA1I CACNA1H GRIN2C GRIN2D	1.51e-06	105	77	6	CID000003954
Drug	gabapentin	CACNB1 CACNB4 SCN3A CACNA1I CACNA1H GRIN2C GRIN2D	1.70e-06	169	77	7	CID000003446
Drug	ES-242-1	MOV10L1 GRIN2C GRIN2D	2.06e-06	8	77	3	CID000131976
Drug	riluzole	CACNB1 CACNB4 SCN3A CACNA1I CACNA1H GRIN2C GRIN2D	2.07e-06	174	77	7	CID000005070
Drug	NSC7524	CACNB1 CACNB4 SCN3A CACNA1I CACNA1H GRIN2C GRIN2D	2.79e-06	182	77	7	CID000005657
Drug	Landel	CACNA1I CACNA1H PGC	3.08e-06	9	77	3	CID000163838
Drug	guanosine 3',5'-cyclic monophosphoric acid	ADCY10 CACNB1 CACNB4 MAPK12 CACNA1I CACNA1H GRIN2C ODC1 GRIN2D SLC24A1 PGC	3.70e-06	577	77	11	CID000000295
Drug	baclofen	ADCY10 CACNB1 CACNB4 CACNA1I CACNA1H GRIN2C GRIN2D	3.84e-06	191	77	7	CID000002284
Drug	CNS 1145	CACNB1 CACNB4 CACNA1I CACNA1H	4.59e-06	33	77	4	CID000190902
Drug	IHC-64	CACNB1 CACNB4 CACNA1I CACNA1H	4.59e-06	33	77	4	CID000162753
Drug	lanthanum	CACNB1 CACNB4 TRPM5 CACNA1I CACNA1H NUP214	6.81e-06	136	77	6	CID000023926
Drug	nimodipine	CACNB1 CACNB4 CACNA1I CACNA1H GRIN2C GRIN2D	9.83e-06	145	77	6	CID000004497
Drug	BLX 1002	PRKAA1 PRKAA2	1.13e-05	2	77	2	ctd:C542815
Drug	N-methyl-DL-aspartic acid	CACNB1 CACNB4 GNPTAB CACNA1I CACNA1H NUP214 GRIN2C GRIN2D SLC24A1 CABIN1 RAB3A	1.22e-05	655	77	11	CID000004376
Drug	manidipine	CACNB1 CACNB4 CACNA1I CACNA1H PGC	1.77e-05	95	77	5	CID000004008
Drug	Verapamil	CACNB1 CACNB4 CACNA1I	2.02e-05	16	77	3	DB00661
Drug	isradipine	CACNB1 CACNB4 SCN3A CACNA1I CACNA1H	2.27e-05	100	77	5	CID000003784
Drug	Zonisamide	SCN3A CACNA1I CACNA1H	2.44e-05	17	77	3	DB00909
Drug	cyclothiazide	CACNB1 SLC8A2 GRIN2C GRIN2D SLC24A1	2.62e-05	103	77	5	CID000002910
Drug	potassium	CACNB1 SLC8A2 CACNB4 SLC8A3 TRPM5 SCN3A CACNA1I CACNA1H GRIN2C ODC1 GRIN2D SLC24A1 RAB3A	3.07e-05	1008	77	13	CID000000813
Drug	SureCN2398996	CACNA1I CACNA1H	3.38e-05	3	77	2	CID010220069
Drug	N-desmethylmethsuximide	CACNA1I CACNA1H	3.38e-05	3	77	2	CID000092154
Drug	1,3-dioxoisoindoline-5-carboxamide	CACNA1I CACNA1H	3.38e-05	3	77	2	CID010679219
Drug	Cinildipine	CACNB1 CACNB4 CACNA1I CACNA1H	3.89e-05	56	77	4	CID000002752
Drug	Nimesulide [51803-78-2]; Up 200; 13uM; MCF7; HT_HG-U133A	CACNB1 CDC42BPA PCNX1 CACNA1I SERPINA10 RAB3B	4.94e-05	193	77	6	2275_UP
Drug	Serotonin hydrochloride [153-98-0]; Up 200; 18.8uM; MCF7; HT_HG-U133A	CACNB1 DDX17 CACNA1H SLC24A1 CBL RAB3B	4.94e-05	193	77	6	5268_UP
Drug	nilvadipine	CACNB1 CACNB4 CACNA1I CACNA1H	5.11e-05	60	77	4	CID000004494
Drug	Oxymetazoline hydrochloride [2315-02-8]; Down 200; 13.4uM; MCF7; HT_HG-U133A	DDX17 CDC42BPA PCNX1 CACNA1H NUP214 CBL	5.23e-05	195	77	6	2278_DN
Drug	PHA-00745360 [351320-33-7]; Down 200; 1uM; MCF7; HT_HG-U133A	UBE3A PRKAA2 CACNA1I NUP214 SLC24A1 RAB3B	5.23e-05	195	77	6	4384_DN
Drug	Bicuculline (+) [485-49-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A	CACNB1 CACNA1H HIF3A SLC24A1 CABIN1 RAB3B	5.23e-05	195	77	6	2796_UP
Drug	Glycocholic acid [475-31-0]; Up 200; 8.6uM; MCF7; HT_HG-U133A	CACNB1 CDC42BPA CACNA1I CACNA1H NUP214 SLC24A1	5.38e-05	196	77	6	3315_UP
Drug	IAA-94	CACNB1 CACNB4 CACNA1I CACNA1H	5.45e-05	61	77	4	CID000003667
Drug	Metoprolol-(+,-) (+)-tartrate salt [56392-17-7]; Down 200; 5.8uM; HL60; HT_HG-U133A	FRY NOD1 DDX17 GNPTAB CBL TRRAP	5.53e-05	197	77	6	2543_DN
Drug	(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Down 200; 11.8uM; MCF7; HT_HG-U133A	NOD1 PCNX1 CACNA1H NUP214 CBL RAB3A	5.69e-05	198	77	6	6053_DN
Drug	Adrenosterone [382-45-6]; Down 200; 13.4uM; PC3; HT_HG-U133A	CDC42BPA MAPK12 UGGT2 CABIN1 CBL RAB3B	5.85e-05	199	77	6	5045_DN
Drug	Trolox [53188-07-1]; Up 200; 16uM; MCF7; HT_HG-U133A	UBE3A PCNX1 CACNA1H NUP214 SLC24A1 RAB3B	5.85e-05	199	77	6	6007_UP
Drug	Dropropizine (R,S) [17692-31-8]; Up 200; 17uM; MCF7; HT_HG-U133A	CACNB1 DDX17 GNPTAB PCNX1 SLC24A1 CBL	5.85e-05	199	77	6	7429_UP
Drug	colchicine; Down 200; 0.1uM; MCF7; HG-U133A	DDX17 CDC42BPA UBE3A PRKAA1 SLC19A3 FBXO11	5.85e-05	199	77	6	644_DN
Drug	Xylazine [7361-61-7]; Up 200; 18.2uM; MCF7; HT_HG-U133A	CACNB1 FRY PRKAA2 CACNA1I CABIN1 RAB3A	6.02e-05	200	77	6	2788_UP
Drug	lercanidipine	CACNB1 CACNB4 CACNA1I CACNA1H	6.19e-05	63	77	4	CID000065866
Drug	YM90K	GRIN2C GRIN2D CABIN1	6.27e-05	23	77	3	CID005486547
Drug	methsuximide	CACNA1I CACNA1H	6.74e-05	4	77	2	CID000006476
Drug	N,N'-bis(3-aminopropyl)cadaverine	AZIN2 ODC1	6.74e-05	4	77	2	CID003080781
Drug	enzacamene	CACNB1 CACNA1I CACNA1H GRIN2C GRIN2D	7.70e-05	129	77	5	ctd:C038939
Drug	gallopamil	CACNB1 CACNB4 CACNA1I CACNA1H	7.88e-05	67	77	4	CID000001234
Drug	nifedipine	CACNB1 CACNB4 CACNA1I CACNA1H GRIN2C GRIN2D CABIN1 PGC	7.99e-05	415	77	8	CID000004485
Drug	glutamate	CACNB1 CACNB4 TRPM5 MAPK12 AZIN2 CACNA1I CACNA1H GRIN2C ODC1 GRIN2D CABIN1 RAB3A	8.82e-05	962	77	12	CID000000611
Drug	AC1L2AC7	CACNB1 CACNB4 CACNA1I CACNA1H	8.85e-05	69	77	4	CID000068733
Drug	amiloride	CACNB1 SLC8A2 SLC19A3 CACNA1I CACNA1H ODC1 SLC24A1	9.53e-05	315	77	7	CID000016230
Drug	octylmethoxycinnamate	CACNB1 CACNA1I CACNA1H GRIN2C GRIN2D	1.10e-04	139	77	5	ctd:C118580
Drug	CAS 298-57-7	CACNB1 CACNB4 CACNA1I CACNA1H	1.10e-04	73	77	4	CID000002761
Drug	5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione	GRIN2C GRIN2D	1.12e-04	5	77	2	ctd:C498554
Drug	AC1O7G5C	CACNA1I CACNA1H	1.12e-04	5	77	2	CID006603942
Drug	2-Aminoadipic Acid	GRIN2C GRIN2D	1.12e-04	5	77	2	ctd:D015074
Drug	(2S,3R)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid	GRIN2C GRIN2D	1.12e-04	5	77	2	ctd:C491996
Drug	phensuximide	CACNA1I CACNA1H	1.12e-04	5	77	2	CID000006839
Drug	Flunarizine	CACNA1I CACNA1H	1.12e-04	5	77	2	DB04841
Drug	SDZ EAA 494	GRIN2C GRIN2D	1.12e-04	5	77	2	ctd:C065286
Drug	ethosuximide	CACNB1 CACNB4 CACNA1I CACNA1H	1.16e-04	74	77	4	CID000003291
Drug	D-myo-inositol-1,4,5-triphosphate	CACNB1 CACNB4 SLC8A3 MAPK12 CACNA1I CACNA1H CABIN1 RAB3A RAB3B	1.25e-04	568	77	9	CID000000806
Drug	nicardipine	CACNB1 CACNB4 CACNA1I CACNA1H NUP214	1.34e-04	145	77	5	CID000004473
Drug	AC1L32TU	GRIN2C ODC1 GRIN2D	1.41e-04	30	77	3	CID000107831
Drug	nisoldipine	CACNB1 CACNB4 CACNA1I CACNA1H	1.43e-04	78	77	4	CID000004499
Drug	imipramine	NUP214 SSR1 GRIN2C ODC1 GRIN2D PLXNA1	1.46e-04	235	77	6	CID000003696
Drug	N-cyclopentyl-N-cyclobutylformamide	CACNB1 CACNB4 CACNA1I CACNA1H	1.50e-04	79	77	4	CID005287890
Drug	AC1MQ5W8	CACNA1I CACNA1H	1.68e-04	6	77	2	CID003396482
Drug	cerebrocrast	CACNA1I CACNA1H	1.68e-04	6	77	2	CID000159556
Drug	Naphthols	GRIN2C GRIN2D	1.68e-04	6	77	2	ctd:D009284
Drug	Meperidine	GRIN2C GRIN2D	1.68e-04	6	77	2	DB00454
Drug	1,5-(diethylamino)piperidine	GRIN2C GRIN2D	1.68e-04	6	77	2	CID000004025
Drug	3,4-dihydroquinazoline	CACNA1I CACNA1H	1.68e-04	6	77	2	CID000583065
Drug	6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one	PRKAA1 PRKAA2	1.68e-04	6	77	2	ctd:C438505
Drug	procaine	CACNB1 CACNB4 SCN3A CACNA1I CACNA1H	1.72e-04	153	77	5	CID000004914
Drug	oriens	SLC8A2 NUP214 GRIN2C GRIN2D RAB3A	1.77e-04	154	77	5	CID000161645
Drug	pentamidine	GRIN2C ODC1 GRIN2D	1.89e-04	33	77	3	CID000004735
Drug	butylparaben	CACNB1 CACNA1I CACNA1H GRIN2C GRIN2D	1.94e-04	157	77	5	ctd:C038091
Drug	KMBA	TRPM5 AZIN2 ODC1	2.06e-04	34	77	3	CID000000473
Drug	N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid	ADCY10 SLC8A3 GRIN2D	2.25e-04	35	77	3	ctd:C520612
Drug	Tenocyclidine	GRIN2C GRIN2D	2.34e-04	7	77	2	DB01520
Drug	LY215840	CACNA1I CACNA1H	2.34e-04	7	77	2	CID000132049
Drug	3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid	GRIN2C GRIN2D	2.34e-04	7	77	2	ctd:C050592
Drug	tetrazol-5-yl)glycine	GRIN2C GRIN2D	2.34e-04	7	77	2	CID000126383
Drug	homoquinolinate	GRIN2C GRIN2D	2.34e-04	7	77	2	CID003080554
Drug	S)-piperazine-2-carboxylic acid	GRIN2C GRIN2D	2.34e-04	7	77	2	CID001502069
Drug	losigamone	CACNA1I CACNA1H	2.34e-04	7	77	2	CID000060572
Drug	AC1NDT8A	SLC8A2 SLC8A3 SLC24A1	2.66e-04	37	77	3	CID004631218
Drug	AC1MMLID	SLC8A2 SLC8A3 SLC24A1 CABIN1	2.70e-04	92	77	4	CID000013245
Drug	6-chloroquinoxaline-2,3-diol	GRIN2C GRIN2D	3.12e-04	8	77	2	CID000081143
Drug	SDZ 220-581	GRIN2C GRIN2D	3.12e-04	8	77	2	CID000128019
Drug	3alpha5betaHS	GRIN2C GRIN2D	3.12e-04	8	77	2	CID000165024
Drug	neramexane	GRIN2C GRIN2D	3.12e-04	8	77	2	CID006433106
Drug	piperazine-2,3-dicarboxylic acid	GRIN2C GRIN2D	3.12e-04	8	77	2	CID000280973
Drug	L-687,414	GRIN2C GRIN2D	3.12e-04	8	77	2	CID000125556
Drug	papaverine	ENPP6 CACNB1 CACNB4 CACNA1I CACNA1H	3.29e-04	176	77	5	CID000004680
Drug	isotetrandrine	CACNB1 CACNB4 CACNA1I CACNA1H	3.30e-04	97	77	4	CID000005422
Drug	ginsenoside Rg3	GRIN2C ODC1 GRIN2D	3.36e-04	40	77	3	CID000159727
Disease	epilepsy (implicated_via_orthology)	UBE3A SCN3A GRIN2C GRIN2D RAB3A RAB3B	2.76e-06	163	71	6	DOID:1826 (implicated_via_orthology)
Disease	Ectodermal Dysplasia	BMS1 ODC1	8.51e-05	6	71	2	C0013575
Disease	Epilepsy, Generalized	CACNB4 CACNA1H	8.51e-05	6	71	2	C0014548
Disease	Idiopathic generalized epilepsy	CACNB4 CACNA1H	8.51e-05	6	71	2	cv:C0270850
Disease	developmental disorder of mental health (implicated_via_orthology)	RASAL3 GRIN2C GRIN2D	2.27e-04	49	71	3	DOID:0060037 (implicated_via_orthology)
Disease	4-acetamidobutanoate measurement	MAPK12 MOV10L1	6.70e-04	16	71	2	EFO_0021003
Disease	thyroxine measurement, triiodothyronine measurement	MAPK12 CCDC80	7.58e-04	17	71	2	EFO_0005130, EFO_0008392
Disease	Impaired glucose tolerance	PRKAA1 PRKAA2	1.65e-03	25	71	2	C0271650
Disease	status epilepticus (biomarker_via_orthology)	SLC8A2 SLC8A3 XRN2	1.83e-03	100	71	3	DOID:1824 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TVEYIEALELMFSMF	CYP27C1	251	Q4G0S4
GYEVTDMMQKALFDF	CACNB1	241	Q02641
MVMEYVSGGELFDYI	PRKAA2	91	P54646
MAGYLSESDFVMVEE	AZIN2	1	Q96A70
MDYFDGVLMFVDISG	ADCY10	36	Q96PN6
SLFDEFMEMMIQYGF	ANO9	536	A1A5B4
MSLGIMEEEDLAEYF	CCDC42	1	Q96M95
LMLIDASFGFEMETF	BMS1	151	Q14692
GYEVTDMMQKALFDF	CACNB4	231	O00305
GMTYNDFFMVLTDVD	CCDC80	706	Q76M96
LMDEYLEMVLQFGFT	ANO3	751	Q9BYT9
EKEAYMGFMNSFLEE	RASAL3	656	Q86YV0
MGFILMYDITNEESF	RAB3A	96	P20336
MGFILMYDITNEESF	RAB3B	96	P20337
EMFLLTVMAFDLYTA	OR4M2B	111	A0A0X1KG70
GAEMVLFTTMAYDRY	OR13G1	106	Q8NGZ3
YGMIDDMIYFSSDAV	MOV10L1	51	Q9BXT6
GMMYVFVALAIVCDE	SLC24A1	461	O60721
YRFEIMGEEEIAFKM	GNPTAB	1111	Q3T906
RLMFTMYDLDENGFL	DUOX2	861	Q9NRD8
VSYLVFDEADRMFDM	DDX42	401	Q86XP3
YEAFSETMLLDLFFM	PCNX1	1426	Q96RV3
LMANEEDADMFGFVY	PLXNA1	206	Q9UIW2
FTFMESGVLLAMAFD	OR51F2	121	Q8NH61
FVGASEMFLLTVMAY	OR4M1	106	Q8NGD0
EMFLLTVMAFDLYTA	OR4M2	111	Q8NGB6
YDFALDKIGMEIMSY	CSTF3	126	Q12996
MLMSFLVDDYTFNVD	NELFB	376	Q8WX92
EEIYMDTIMELVGFS	NOD1	156	Q9Y239
MMSSEYGSIIAFFDV	NUP214	111	P35658
GEMVMLYDLFFAFLQ	LRPPRC	886	P42704
NEMEMYLASFVFVVL	OR2C3	196	Q8N628
FILAAMAFDRYMAIG	OR5M3	111	Q8NGP4
EMILAAIFFVVYMCD	PLP2	56	Q04941
AVYDTDVFALLTAMM	OTOP2	56	Q7RTS6
VLTAYLDYMEELGML	EEF1AKMT4-ECE2	391	P0DPD8
LETAMEFYLEAVMLD	CABIN1	106	Q9Y6J0
VFMEGSEDAYVGYMT	FBXO11	331	Q86XK2
NRLDFFIVMAGMVEY	CACNA1I	151	Q9P0X4
VLMYASFGFVDLEEM	C19orf67	176	A6NJJ6
METLGENEYFRVFME	CBL	106	P22681
YLVLDEADRMLDMGF	DDX17	321	Q92841
LMESDFEFEYLMALR	FRY	2051	Q5TBA9
YLVLDEADRMLDMGF	DDX3Y	341	O15523
YDNELMDMRGIFLAF	ENPP6	356	Q6UWR7
FFIVVAGMMEYSLDG	CACNA1H	176	O95180
SYEFFAVTRFLVGMM	SLC22A15	161	Q8IZD6
MQVVEFFYGMVTAAE	SLC19A3	106	Q9BZV2
AFAAGAMVYVVMDDI	SLC39A11	296	Q8N1S5
FEGMLLFYTDFMGEV	SLC45A1	571	Q9Y2W3
DISDTLMYVYEMLGA	IPO13	426	O94829
RCVFDMGAEVGFSMY	ODC1	216	P11926
PVVARMIYEMFSGDF	IRF6	396	O14896
FFGIVDSVIIAMMAY	OR1M1	106	Q8NGA1
DSVIIAMMAYDRFVA	OR1M1	111	Q8NGA1
GMEAEVLLAMAFDRY	OR52J3	111	Q8NH60
DGLDGETIFMYMFLA	SSR1	201	P43307
EELFSGMYIDFMGTD	SEMA3C	181	Q99985
GMYIDFMGTDAAIFR	SEMA3C	186	Q99985
FVMVLTAEGDMAYLS	HIF3A	96	Q9Y2N7
IVGMFLAEMIEKYFV	SCN3A	1601	Q9NY46
DMARFYLAEMVIAID	CDC42BPA	176	Q5VT25
RFFVMYADGSGMELL	SPAG17	1641	Q6Q759
FMVMEYVSGGELFDY	PRKAA1	101	Q13131
GAVMFGREFCYAMET	SLC45A4	56	Q5BKX6
VVTAEAFAALIDMMY	ZBTB5	71	O15062
LEYEGNVEDDMMITF	UBE3A	666	Q05086
FEAGRTVLAMDFMVF	TRPM5	831	Q9NZQ8
MAYMDAAYFGEISIG	PGC	66	P20142
EMMVAIFEYIDRLFS	XRN2	76	Q9H0D6
HFMIYEETSGMLLFL	SERPINA10	421	Q9UK55
KLEGFALMADMVYVT	SNRNP200	1071	O75643
EYFMVQEELAFVFEM	TRAPPC10	221	P48553
VDMDVYDAFSILDML	UGGT2	386	Q9NYU1
EMTAEFYALKGMFLA	TRRAP	3116	Q9Y4A5
DFTDFYLVMPFMGTD	MAPK12	101	P53778
YMFLGVSIIADRFMA	SLC8A2	81	Q9UPR5
YMFLGVSIIADRFMA	SLC8A3	86	P57103
MTFELYEEFLRAMGL	MYO9A	2146	B2RTY4
DIDNMAGVFYMLLVA	GRIN2C	811	Q14957
DIDNMAGVFYMLLVA	GRIN2D	841	O15399