Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

1.41e-174318922GO:0004984
GeneOntologyMolecularFunctionodorant binding

OR5W2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR5L1 OR9I1 OR1K1 OR5L2 OR8U9 OR8U8 OR8G1

1.39e-141278913GO:0005549
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OXGR1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 ADGRF1 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

4.92e-138848924GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 NRXN2 OR51Q1 OR5L1 OR9I1 OXGR1 OR3A3 OR1K1 OR2J2 PTPRU OR10G9 OR5L2 ADGRF1 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

1.03e-1013538926GO:0004888
GeneOntologyMolecularFunctiongrowth hormone receptor binding

JAK3 CSH1 CSH2 CSHL1

7.59e-0810894GO:0005131
GeneOntologyMolecularFunctionprolactin receptor binding

CSH1 CSH2 CSHL1

2.96e-067893GO:0005148
GeneOntologyMolecularFunctionhormone receptor binding

JAK3 CSH1 CSH2 CSHL1

1.54e-0534894GO:0051427
GeneOntologyMolecularFunctionpotassium:sodium symporter activity

SLC12A1 SLC12A3

5.88e-053892GO:0009674
GeneOntologyMolecularFunctionsodium:potassium:chloride symporter activity

SLC12A1 SLC12A3

5.88e-053892GO:0008511
GeneOntologyMolecularFunctionpotassium:chloride symporter activity

SLC12A1 SLC12A3

6.93e-049892GO:0015379
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

9.80e-184329022GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

4.63e-174659022GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

1.12e-164859022GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

5.61e-165249022GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

1.37e-155479022GO:0007606
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

4.90e-155829022GO:0050906
GeneOntologyBiologicalProcessdetection of stimulus

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

3.86e-137229022GO:0051606
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 GNA14 OR5AK2 OR51Q1 OR5L1 ATRNL1 OR9I1 OXGR1 OR3A3 OR1K1 NR3C2 OR2J2 OR10G9 OR5L2 ADGRF1 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

2.20e-1113959027GO:0007186
GeneOntologyBiologicalProcesssensory perception

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

8.16e-1010729022GO:0007600
GeneOntologyBiologicalProcessgrowth hormone receptor signaling pathway

JAK3 CSH1 CSH2 CSHL1

4.71e-0626904GO:0060396
GeneOntologyBiologicalProcesscellular response to growth hormone stimulus

JAK3 CSH1 CSH2 CSHL1

5.51e-0627904GO:0071378
GeneOntologyBiologicalProcesspositive regulation of steroid hormone biosynthetic process

CSH1 CSH2 CSHL1

2.23e-0513903GO:0090031
GeneOntologyBiologicalProcessresponse to growth hormone

JAK3 CSH1 CSH2 CSHL1

3.03e-0541904GO:0060416
GeneOntologyBiologicalProcesspositive regulation of hormone biosynthetic process

CSH1 CSH2 CSHL1

7.40e-0519903GO:0046886
GeneOntologyBiologicalProcessregulation of steroid hormone biosynthetic process

CSH1 CSH2 CSHL1

1.52e-0424903GO:0090030
GeneOntologyBiologicalProcessestrogen catabolic process

UGT1A10 UGT1A8

1.87e-045902GO:0006711
GeneOntologyBiologicalProcesspositive regulation of hormone metabolic process

CSH1 CSH2 CSHL1

1.94e-0426903GO:0032352
GeneOntologyBiologicalProcessphenylpropanoid catabolic process

UGT1A10 UGT1A8

2.79e-046902GO:0046271
GeneOntologyBiologicalProcesscoumarin catabolic process

UGT1A10 UGT1A8

2.79e-046902GO:0046226
GeneOntologyBiologicalProcessflavone metabolic process

UGT1A10 UGT1A8

2.79e-046902GO:0051552
GeneOntologyBiologicalProcessregulation of hormone biosynthetic process

CSH1 CSH2 CSHL1

5.17e-0436903GO:0046885
GeneOntologyBiologicalProcesspotassium ion homeostasis

SLC12A1 SLC12A3 NR3C2

5.61e-0437903GO:0055075
GeneOntologyBiologicalProcesspositive regulation of steroid biosynthetic process

CSH1 CSH2 CSHL1

6.07e-0438903GO:0010893
GeneOntologyBiologicalProcesstyrosine phosphorylation of STAT protein

JAK3 CSH1 CSH2 CSHL1

6.51e-0490904GO:0007260
GeneOntologyBiologicalProcesspositive regulation of steroid metabolic process

CSH1 CSH2 CSHL1

8.15e-0442903GO:0045940
GeneOntologyBiologicalProcessphenylpropanoid metabolic process

UGT1A10 UGT1A8

8.28e-0410902GO:0009698
GeneOntologyBiologicalProcesscoumarin metabolic process

UGT1A10 UGT1A8

8.28e-0410902GO:0009804
GeneOntologyCellularComponentgrowth hormone receptor complex

CSH1 CSH2 CSHL1

1.58e-066913GO:0070195
MousePhenodecreased pituitary gland weight

CSH1 CSH2 CSHL1

3.55e-068573MP:0008938
MousePhenoabsent somatotrophs

CSH1 CSH2 CSHL1

5.31e-069573MP:0008330
MousePhenoabsent lactotrophs

CSH1 CSH2 CSHL1

5.31e-069573MP:0008333
MousePhenoincreased circulating ghrelin level

CSH1 CSH2 CSHL1

1.38e-0512573MP:0011612
MousePhenoabnormal pituitary gland weight

CSH1 CSH2 CSHL1

1.38e-0512573MP:0008937
MousePhenoabnormal circulating ghrelin level

CSH1 CSH2 CSHL1

2.82e-0515573MP:0011611
MousePhenodecreased lactotroph cell number

CSH1 CSH2 CSHL1

4.20e-0517573MP:0008332
MousePhenothick retina inner plexiform layer

DSCAM DSCAML1

4.89e-053572MP:0014265
MousePhenoabnormal lactotroph morphology

CSH1 CSH2 CSHL1

5.95e-0519573MP:0008323
MousePhenodecreased somatotroph cell number

CSH1 CSH2 CSHL1

8.11e-0521573MP:0008329
MousePhenoabnormal renal transport

SLC12A1 SLC12A3 NR3C2

1.07e-0423573MP:0011417
MousePhenosmall adenohypophysis

CSH1 CSH2 CSHL1

1.07e-0423573MP:0008321
MousePhenoabnormal somatotroph morphology

CSH1 CSH2 CSHL1

1.22e-0424573MP:0008322
MousePhenodelayed vaginal opening

CSH1 CSH2 CSHL1

1.96e-0428573MP:0002636
MousePhenosmall pituitary gland

CSH1 CSH2 CSHL1

2.41e-0430573MP:0005361
MousePhenoabnormal timing of vaginal opening

CSH1 CSH2 CSHL1

2.66e-0431573MP:0020150
MousePhenoabnormal renal sodium ion transport

SLC12A3 NR3C2

4.50e-048572MP:0011442
MousePhenoabnormal pituitary gland size

CSH1 CSH2 CSHL1

6.59e-0442573MP:0008936
MousePhenoincreased brown adipose tissue amount

CSH1 CSH2 CSHL1

7.07e-0443573MP:0000005
DomainOlfact_rcpt

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

7.93e-183938922IPR000725
DomainGPCR_Rhodpsn_7TM

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OXGR1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

5.02e-146708923IPR017452
Domain7tm_1

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OXGR1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

6.24e-146778923PF00001
DomainG_PROTEIN_RECEP_F1_1

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OXGR1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

7.99e-146858923PS00237
DomainG_PROTEIN_RECEP_F1_2

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OXGR1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

9.59e-146918923PS50262
DomainGPCR_Rhodpsn

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OXGR1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

9.89e-146928923IPR000276
DomainSOMATOTROPIN_2

CSH1 CSH2 CSHL1

2.07e-066893PS00338
DomainHormone_1

CSH1 CSH2 CSHL1

2.07e-066893PF00103
DomainSOMATOTROPIN_1

CSH1 CSH2 CSHL1

2.07e-066893PS00266
DomainSomatotropin

CSH1 CSH2 CSHL1

3.61e-067893IPR001400
DomainAA_permease_N

SLC12A1 SLC12A3

6.72e-053892IPR013612
DomainAA_permease_N

SLC12A1 SLC12A3

6.72e-053892PF08403
DomainSomatotropin_CS

CSH1 CSHL1

2.22e-045892IPR018116
DomainIGv

DSCAM HAPLN4 BTNL9 DSCAML1

4.52e-0475894SM00406
DomainSLC12A_fam

SLC12A1 SLC12A3

4.64e-047892IPR004842
DomainSLC12_C

SLC12A1 SLC12A3

6.17e-048892IPR018491
DomainSLC12

SLC12A1 SLC12A3

6.17e-048892PF03522
Domain4_helix_cytokine_core

CSH1 CSH2 CSHL1

1.85e-0351893IPR012351
DomainLRR_6

CEP78 NLRP1 NLRP5

2.29e-0355893PF13516
DomainUDPGT

UGT1A10 UGT1A8

4.45e-0321892PF00201
DomainUDPGT

UGT1A10 UGT1A8

4.45e-0321892PS00375
DomainUDP_glucos_trans

UGT1A10 UGT1A8

4.45e-0321892IPR002213
DomainAA-permease/SLC12A_dom

SLC12A1 SLC12A3

4.87e-0322892IPR004841
DomainDAPIN

NLRP1 NLRP5

4.87e-0322892PS50824
DomainPYRIN

NLRP1 NLRP5

4.87e-0322892PF02758
DomainAA_permease

SLC12A1 SLC12A3

4.87e-0322892PF00324
DomainDAPIN

NLRP1 NLRP5

4.87e-0322892IPR004020
DomainPYRIN

NLRP1 NLRP5

4.87e-0322892SM01289
Domain4_helix_cytokine-like_core

CSH1 CSH2 CSHL1

5.31e-0374893IPR009079
DomainNACHT

NLRP1 NLRP5

5.32e-0323892PS50837
DomainNACHT_NTPase

NLRP1 NLRP5

5.32e-0323892IPR007111
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

2.18e-174176922M4072
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U8 OR10G7 OR10G4 OR8G1

1.35e-153896920M14091
PathwayREACTOME_SENSORY_PERCEPTION

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR3A3 OR1K1 OR2J2 OR10G9 OR5L2 OR9A2 OR8U9 OR8U8 OR10G7 OR10G4 OR8G1

1.39e-136366922M41834
PathwayREACTOME_PROLACTIN_RECEPTOR_SIGNALING

CSH1 CSH2 CSHL1

3.10e-0513693MM14516
PathwayREACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING

CSH1 CSH2 CSHL1

6.00e-0516693MM15710
PathwayBIOCARTA_LONGEVITY_PATHWAY

CSH1 CSH2 CSHL1

1.03e-0419693MM1513
PathwayREACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN

CSH1 CSH2 CSHL1

1.21e-0420693MM15070
PathwayBIOCARTA_AKT_PATHWAY

CSH1 CSH2 CSHL1

2.69e-0426693MM1345
PathwayBIOCARTA_TFF_PATHWAY

CSH1 CSH2 CSHL1

3.74e-0429693MM1522
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR2J2 OR10G9 OR10G7 OR10G4

3.78e-0470694MM14984
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A1 SLC12A3

4.88e-047692M27339
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A1 SLC12A3

4.88e-047692MM15081
PathwayBIOCARTA_GH_PATHWAY

CSH1 CSH2 CSHL1

5.51e-0433693MM1404
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR5W2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR2J2 OR10G9 OR5L2 OR9A2 OR10G7 OR10G4 OR8G1

7.88e-16340921611875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR5W2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR2J2 OR10G9 OR5L2 OR9A2 OR10G7 OR10G4 OR8G1

7.88e-16340921611802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR5W2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR2J2 OR10G9 OR5L2 OR9A2 OR10G7 OR10G4 OR8G1

9.04e-16343921632295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR5W2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR51Q1 OR5L1 OR9I1 OR2J2 OR10G9 OR5L2 OR9A2 OR10G7 OR10G4 OR8G1

1.04e-15346921614611657
Pubmed

The human olfactory receptor gene family.

OR5W2 OR51L1 OR3A2 OR5D16 OR5M10 OR5M1 OR5AK2 OR5L1 OR9I1 OR3A3 OR2J2 OR10G9 OR5L2 OR9A2 OR10G7 OR10G4 OR8G1

6.85e-14541921714983052
Pubmed

The age-associated decline of glycogen synthase kinase 3beta plays a critical role in the inhibition of liver regeneration.

CCND3 CSH1 CSH2 CSHL1

5.72e-09992419398579
Pubmed

The human growth hormone gene locus: structure, evolution, and allelic variations.

CSH1 CSH2 CSHL1

1.79e-0839233030680
Pubmed

Developmental control and alternative splicing of the placentally expressed transcripts from the human growth hormone gene cluster.

CSH1 CSH2 CSHL1

7.15e-0849231378436
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR5W2 OR5D16 OR5M1 OR9I1 OR3A3 OR1K1 OR5L2 OR8G1

1.29e-0721992812213199
Pubmed

Central growth hormone action regulates metabolism during pregnancy.

CSH1 CSH2 CSHL1

1.78e-07592331479305
Pubmed

Molecular evolution of growth hormone and receptor in the guinea-pig, a mammal unresponsive to growth hormone.

CSH1 CSH2 CSHL1

1.78e-07592310767558
Pubmed

High, persistent hepatocellular proliferation and apoptosis precede hepatocarcinogenesis in growth hormone transgenic mice.

CSH1 CSH2 CSHL1

1.78e-07592310395045
Pubmed

Effect of genetic background on growth of mice hemizygous for wild-type or dwarf mutated bovine growth hormone transgenes.

CSH1 CSH2 CSHL1

1.78e-07592324190208
Pubmed

Heterogeneous growth hormone (GH) gene mutations in familial GH deficiency.

CSH1 CSH2 CSHL1

1.78e-0759238496314
Pubmed

Brief report: short stature caused by a mutant growth hormone.

CSH1 CSH2 CSHL1

1.78e-0759238552145
Pubmed

Exploring endocrine GH pattern in mice using rank plot analysis and random blood samples.

CSH1 CSH2 CSHL1

1.78e-07592321045135
Pubmed

Promotion of Joint Degeneration and Chondrocyte Metabolic Dysfunction by Excessive Growth Hormone in Mice.

CSH1 CSH2 CSHL1

1.78e-07592336762426
Pubmed

High molecular weight isoforms of growth hormone in cells of the immune system.

CSH1 CSH2 CSHL1

1.78e-07592321741628
Pubmed

Analysis of gender difference of cardiac risk biomarkers using hGH-transgenic mice.

CSH1 CSH2 CSHL1

1.78e-07592316508206
Pubmed

Structure of the growth hormone-encoding gene and its promoter in mice.

CSH1 CSH2 CSHL1

1.78e-0759238647448
Pubmed

Thiol-Disulfide Exchange in Human Growth Hormone.

CSH1 CSH2 CSHL1

1.78e-07592326887678
Pubmed

Rescue of pituitary function in a mouse model of isolated growth hormone deficiency type II by RNA interference.

CSH1 CSH2 CSHL1

1.78e-07592318006625
Pubmed

Transgenic mice expressing bovine GH develop arthritic disorder and self-antibodies.

CSH1 CSH2 CSHL1

1.78e-07592310810296
Pubmed

Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia.

CSH1 CSH2 CSHL1

1.78e-07592315616010
Pubmed

Nitric oxide stimulates embryonic somatotroph differentiation and growth hormone mRNA and protein expression through a cyclic guanosine monophosphate-independent mechanism.

CSH1 CSH2 CSHL1

1.78e-07592319019400
Pubmed

The Effects of 20-kDa Human Placental GH in Male and Female GH-deficient Mice: An Improved Human GH?

CSH1 CSH2 CSHL1

1.78e-07592332556100
Pubmed

High frequency of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice created from two different strains of mice.

CSH1 CSH2 CSHL1

1.78e-0759231525063
Pubmed

The role of growth hormone in fetal mouse reproductive tract differentiation.

CSH1 CSH2 CSHL1

1.78e-0759238756530
Pubmed

GH Knockout Mice Have Increased Subcutaneous Adipose Tissue With Decreased Fibrosis and Enhanced Insulin Sensitivity.

CSH1 CSH2 CSHL1

1.78e-07592331099824
Pubmed

Obesity and elevated plasma leptin concentration in oMT1A-o growth hormone transgenic mice.

CSH1 CSH2 CSHL1

1.78e-07592311346667
Pubmed

Somatotropin transgenic mice have reduced jejunal active glucose transport rates.

CSH1 CSH2 CSHL1

1.78e-0759237965203
Pubmed

Cardiac contractile function is enhanced in isolated ventricular myocytes from growth hormone transgenic mice.

CSH1 CSH2 CSHL1

1.78e-07592312010633
Pubmed

Hot spots for growth hormone gene deletions in homologous regions outside of Alu repeats.

CSH1 CSH2 CSHL1

1.78e-0759231980158
Pubmed

Vitamin D3 cannot revert desensitization of growth hormone (GH)-induced STAT5-signaling in GH-overexpressing mice non-calcemic tissues.

CSH1 CSH2 CSHL1

1.78e-07592317881271
Pubmed

Neural growth hormone implicated in body weight sex differences.

CSH1 CSH2 CSHL1

1.78e-07592323861378
Pubmed

Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis.

CSH1 CSH2 CSHL1

1.78e-07592317626886
Pubmed

Growth hormone prevents the development of autoimmune diabetes.

CSH1 CSH2 CSHL1

1.78e-07592324218587
Pubmed

Regulation of rapid signal transducer and activator of transcription-5 phosphorylation in the resting cells of the growth plate and in the liver by growth hormone and feeding.

CSH1 CSH2 CSHL1

1.78e-07592319359380
Pubmed

Body composition of inactivated growth hormone (oMt1a-oGH) transgenic mice: generation of an obese phenotype.

CSH1 CSH2 CSHL1

1.78e-0759239546108
Pubmed

Growth hormone increases low-density lipoprotein receptor and HMG-CoA reductase mRNA expression in mesangial cells.

CSH1 CSH2 CSHL1

1.78e-07592312759574
Pubmed

Growth hormone production and action in N1E-115 neuroblastoma cells.

CSH1 CSH2 CSHL1

1.78e-07592319301152
Pubmed

Transgene transmission to progeny by oMt1a-oGH transgenic mice.

CSH1 CSH2 CSHL1

1.78e-07592316201410
Pubmed

Growth hormone stimulates the selective trafficking of thymic CD4+CD8- emigrants to peripheral lymphoid organs.

CSH1 CSH2 CSHL1

1.78e-07592315316240
Pubmed

Genes that prolong life: relationships of growth hormone and growth to aging and life span.

CSH1 CSH2 CSHL1

1.78e-07592311487592
Pubmed

Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice.

CSH1 CSH2 CSHL1

1.78e-07592311318985
Pubmed

Adipocyte insensitivity to insulin in growth hormone-transgenic mice.

CSH1 CSH2 CSHL1

1.78e-07592311350075
Pubmed

Transgenic mice overexpressing growth hormone (GH) have reduced or increased cardiac apoptosis through activation of multiple GH-dependent or -independent cell death pathways.

CSH1 CSH2 CSHL1

1.78e-07592318617616
Pubmed

Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice.

CSH1 CSH2 CSHL1

1.78e-07592317347312
Pubmed

Growth hormone and fertility in oMt1a-oGH transgenic mice.

CSH1 CSH2 CSHL1

1.78e-07592311570960
Pubmed

Promoter shuffling has occurred during the evolution of the vertebrate growth hormone gene.

CSH1 CSH2 CSHL1

1.78e-07592310974531
Pubmed

Involvement of insulin-like growth factor-1 in the effect of caloric restriction: regulation of plasma adiponectin and leptin.

CSH1 CSH2 CSHL1

1.78e-07592317301034
Pubmed

Pleiotropic effects of growth hormone signaling in aging.

CSH1 CSH2 CSHL1

1.78e-07592321852148
Pubmed

Body composition, bone mass and microstructural analysis in GH-transgenic mice reveals that skeletal changes are specific to bone compartment and gender.

CSH1 CSH2 CSHL1

1.78e-07592312175649
Pubmed

Transgenic mice reveal novel activities of growth hormone in wound repair, angiogenesis, and myofibroblast differentiation.

CSH1 CSH2 CSHL1

1.78e-07592315070902
Pubmed

Growth hormone action in the developing neural retina: a proteomic analysis.

CSH1 CSH2 CSHL1

1.78e-07592318203262
Pubmed

Hepatocellular alterations and dysregulation of oncogenic pathways in the liver of transgenic mice overexpressing growth hormone.

CSH1 CSH2 CSHL1

1.78e-07592323428905
Pubmed

Identification of the glomerular podocyte as a target for growth hormone action.

CSH1 CSH2 CSHL1

1.78e-07592317272398
Pubmed

A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity.

CSH1 CSH2 CSHL1

1.78e-07592314726450
Pubmed

Glucose homeostasis and insulin sensitivity in growth hormone-transgenic mice: a cross-sectional analysis.

CSH1 CSH2 CSHL1

1.78e-07592320707609
Pubmed

Assignment of the porcine growth hormone gene to chromosome 12.

CSH1 CSH2 CSHL1

1.78e-0759232249485
Pubmed

Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARgamma pathway.

CSH1 CSH2 CSHL1

1.78e-07592317242167
Pubmed

UV photodegradation of murine growth hormone: chemical analysis and immunogenicity consequences.

CSH1 CSH2 CSHL1

1.78e-07592324758742
Pubmed

Consequences of overexpression of growth hormone in transgenic mice on liver cytochrome P450 enzymes.

CSH1 CSH2 CSHL1

1.78e-07592310076541
Pubmed

A single injection of double-stranded adeno-associated viral vector expressing GH normalizes growth in GH-deficient mice.

CSH1 CSH2 CSHL1

1.78e-07592318180319
Pubmed

Overgrowth of skin in growth hormone transgenic mice depends on the presence of male gonads.

CSH1 CSH2 CSHL1

1.78e-07592310594738
Pubmed

Induction of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice.

CSH1 CSH2 CSHL1

1.78e-0759231874564
Pubmed

Hypoxia and cytoplasmic alkalinization upregulate growth hormone expression in lymphocytes.

CSH1 CSH2 CSHL1

1.78e-07592323639351
Pubmed

Cloning and characterisation of the GH gene from the common dolphin (Delphinus delphis).

CSH1 CSH2 CSHL1

1.78e-07592312225773
Pubmed

Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood.

CSH1 CSH2 CSHL1

1.78e-07592321098290
Pubmed

Cardiac expression of adenine nucleotide translocase-1 in transgenic mice overexpressing bovine GH.

CSH1 CSH2 CSHL1

1.78e-07592317761891
Pubmed

Growth Hormone Deficiency and Excess Alter the Gut Microbiome in Adult Male Mice.

CSH1 CSH2 CSHL1

1.78e-07592332100023
Pubmed

The related genes encoding growth hormone and prolactin have been dispersed to chromosomes 10 and 17 in the rat.

CSH1 CSH2 CSHL1

1.78e-0759233780533
Pubmed

Age-related changes in body composition of bovine growth hormone transgenic mice.

CSH1 CSH2 CSHL1

1.78e-07592318948397
Pubmed

The human growth hormone locus: nucleotide sequence, biology, and evolution.

CSH1 CSH2 CSHL1

3.56e-0769232744760
Pubmed

Growth hormone, acting in part through the insulin-like growth factor axis, rescues developmental, but not metabolic, activity in the mammary gland of mice expressing a single allele of the prolactin receptor.

CSH1 CSH2 CSHL1

3.56e-07692312399427
Pubmed

Transgenic mice over-expressing galanin exhibit pituitary adenomas and increased secretion of galanin, prolactin and growth hormone.

CSH1 CSH2 CSHL1

3.56e-07692314596666
Pubmed

GH modulates hepatic epidermal growth factor signaling in the mouse.

CSH1 CSH2 CSHL1

3.56e-07692320032199
Pubmed

Growth inhibition in giant growth hormone transgenic mice by overexpression of insulin-like growth factor-binding protein-2.

CSH1 CSH2 CSHL1

3.56e-07692311316754
Pubmed

Specific interactions of growth hormone (GH) with GH-receptors and GH-binding proteins in vivo in genetically GH-deficient Ames dwarf mice.

CSH1 CSH2 CSHL1

3.56e-07692310984300
Pubmed

Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice.

CSH1 CSH2 CSHL1

3.56e-07692314702113
Pubmed

The use of transgenic mice to analyze the role of accessory factor two in the regulation of phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes.

CSH1 CSH2 CSHL1

3.56e-07692311309401
Pubmed

The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female mice.

CSH1 CSH2 CSHL1

3.56e-07692323150490
Pubmed

Systemic over-secretion of growth hormone in transgenic mice results in a specific pattern of skeletal modeling and adaptation.

CSH1 CSH2 CSHL1

3.56e-0769239556071
Pubmed

Nucleotide sequence of mouse prolactin and growth hormone mRNAs and expression of these mRNAs during pregnancy.

CSH1 CSH2 CSHL1

3.56e-0769232991252
Pubmed

Transgenic studies with a keratin promoter-driven growth hormone transgene: prospects for gene therapy.

CSH1 CSH2 CSHL1

3.56e-0769238990189
Pubmed

Evidence that sensitivity to growth hormone (GH) is growth period and tissue type dependent: studies in GH-deficient lit/lit mice.

CSH1 CSH2 CSHL1

3.56e-07692312933669
Pubmed

Genetic dissection of IGF1-dependent and -independent effects of permanent GH excess on postnatal growth and organ pathology of mice.

CSH1 CSH2 CSHL1

3.56e-07692325017732
Pubmed

Third party data gene data set of eutherian growth hormone genes.

CSH1 CSH2 CSHL1

3.56e-07692326697363
Pubmed

Role of growth hormone in the genetic change of mice divergently selected for body weight and fatness.

CSH1 CSH2 CSHL1

3.56e-07692310689811
Pubmed

Effects of long-term treatment with growth hormone-releasing peptide-2 in the GHRH knockout mouse.

CSH1 CSH2 CSHL1

3.56e-07692315985453
Pubmed

Phosphorylation of sterol regulatory element-binding protein (SREBP)-1a links growth hormone action to lipid metabolism in hepatocytes.

CSH1 CSH2 CSHL1

3.56e-07692320863500
Pubmed

An early reduction in GH peak amplitude in preproghrelin-deficient male mice has a minor impact on linear growth.

CSH1 CSH2 CSHL1

3.56e-07692324949662
Pubmed

Growth Hormone Pulses and Liver Gene Expression Are Differentially Regulated by the Circadian Clock Gene Bmal1.

CSH1 CSH2 CSHL1

3.56e-07692333539533
Pubmed

Growth hormone alters methionine and glutathione metabolism in Ames dwarf mice.

CSH1 CSH2 CSHL1

3.56e-07692315664625
Pubmed

Growth hormone, IGF-I and cancer. Less intervention to avoid cancer? More intervention to prevent cancer?

CSH1 CSH2 CSHL1

3.56e-07692310467223
Pubmed

Role of SOCS2 in growth hormone actions.

CSH1 CSH2 CSHL1

3.56e-07692315734145
Pubmed

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.

CSH1 CSH2 CSHL1

3.56e-07692320231469
Pubmed

The genes for growth hormone and chorionic somatomammotropin are on the long arm of human chromosome 17 in region q21 to qter.

CSH1 CSH2 CSHL1

3.56e-0769236262212
Pubmed

RASSF10 regulates bone invasion of growth hormone-secreting adenomas via exosomes.

CSH1 CSH2 CSHL1

3.56e-07692332423821
Pubmed

Effect of Deletion of Ghrelin-O-Acyltransferase on the Pulsatile Release of Growth Hormone in Mice.

CSH1 CSH2 CSHL1

3.56e-07692326442444
InteractionCSHL1 interactions

CSH1 CSH2 CSHL1

2.08e-067803int:CSHL1
InteractionCSH2 interactions

CSH1 CSH2 CSHL1

2.65e-0515803int:CSH2
CytobandEnsembl 112 genes in cytogenetic band chr11q12

OR5W2 OR5D16 OR5M10 OR8U1 OR5M1 OR5AK2 OR5L1 OR9I1 OR5L2

3.46e-08345929chr11q12
Cytoband11q11

OR5W2 OR5D16 OR5L1 OR5L2 OR8U8

4.15e-084792511q11
Cytoband11q12.1

OR5M10 OR8U1 OR5M1 OR5AK2 OR9I1

1.92e-0516192511q12.1
Cytoband17q24.2

CSH1 CSH2 CSHL1

3.04e-053092317q24.2
CytobandEnsembl 112 genes in cytogenetic band chr11q24

OR10G9 OR10G7 OR10G4 OR8G1

6.10e-04191924chr11q24
CytobandEnsembl 112 genes in cytogenetic band chr17p13

OR3A2 PITPNM3 OR3A3 NLRP1 SMTNL2

6.80e-04346925chr17p13
Cytoband2q37

UGT1A10 UGT1A8

1.78e-03319222q37
CytobandEnsembl 112 genes in cytogenetic band chr17q23

CSH1 CSH2 CSHL1

1.85e-03120923chr17q23
Cytoband11q24.1

OR10G9 OR10G4

2.53e-033792211q24.1
Cytoband19p13.1

JAK3 HAPLN4

4.22e-034892219p13.1
GeneFamilyOlfactory receptors, family 5

OR5W2 OR5D16 OR5M10 OR5M1 OR5AK2 OR5L1 OR5L2

2.78e-07112717152
GeneFamilyGrowth hormone family

CSH1 CSH2 CSHL1

1.15e-0667131175
GeneFamilyOlfactory receptors, family 8

OR8U1 OR8U9 OR8U8 OR8G1

4.05e-0549714155
GeneFamilyOlfactory receptors, family 3

OR3A2 OR3A3

2.26e-046712150
GeneFamilyPotassium voltage-gated channel regulatory subunits|DASH family

DPP6 KCNIP4

1.54e-0315712858
GeneFamilyOlfactory receptors, family 10

OR10G9 OR10G7 OR10G4

2.22e-0366713157
GeneFamilyFibronectin type III domain containing

CHL1 DSCAM PTPRU DSCAML1

3.62e-03160714555
GeneFamilyOlfactory receptors, family 9

OR9I1 OR9A2

3.65e-0323712156
GeneFamilyNLR family

NLRP1 NLRP5

4.30e-0325712666
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

NLRP1 NLRP5

4.30e-0325712994
GeneFamilyUDP glucuronosyltransferases

UGT1A10 UGT1A8

6.99e-0332712363
ToppCellCOVID-19-kidney-CD-IC-A|COVID-19 / Disease (COVID-19 only), tissue and cell type

CHL1 DSCAM OXGR1 KCNIP4 ADGRF1 DSCAML1

1.37e-0617688645028197364c64e93e3ffe86aff773d47a477d49
ToppCellCOVID-19-kidney-DCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC12A3 CPXM2 FARP1 KCNIP4 NR3C2 DSCAML1

2.00e-061888861d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CCND3 CHL1 SLC12A1 SYNE1 KCNIP4 ADGRF1

2.13e-061908863fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CCND3 CHL1 TBC1D8 SYNE1 KCNIP4 ADGRF1

2.33e-06193886f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCND3 CHL1 SLC12A1 KCNIP4 TNFAIP8 ADGRF1

2.33e-06193886263d185af6ed80e639f864e4966268e0862c61dc
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCND3 CHL1 SLC12A1 KCNIP4 TNFAIP8 ADGRF1

2.33e-0619388680e058c224749b5fe0ba3e944b48317c2371cb63
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCND3 CHL1 SLC12A1 KCNIP4 TNFAIP8 ADGRF1

2.33e-06193886b991fbbb4618401624f0b3045f0e81a606d3a763
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CCND3 CHL1 TBC1D8 SYNE1 KCNIP4 ADGRF1

2.33e-0619388642df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CCND3 CHL1 SYNE1 KCNIP4 ADGRF1 DSCAML1

2.40e-06194886e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DSCAM KCNIP4 NR3C2 ADGRF1 DSCAML1

1.91e-051658859bd332e5ede759a00a47728ea5558c215efdd77a
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

DPP6 FARP1 ATRNL1 KCNIP4 DSCAML1

2.75e-05178885544379f5a6145429762258d426b876bb36c112f5
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CHL1 GNA14 ATRNL1 KCNIP4 NR3C2

2.98e-0518188557994ff4ecffb15653aee00644d9f887f5e3461d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCND3 CHL1 SLC12A1 KCNIP4 NR3C2

3.22e-05184885d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHL1 DPP6 DSCAM NRXN2 SULF1

3.22e-05184885278a7ed764c326450cb70e69ed2175980eaf5fe0
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHL1 DPP6 DSCAM NRXN2 SULF1

3.22e-051848858d86e125257ff1d3af8d90577a8b3f0321eca21c
ToppCellfacs-Skin-Telogen-3m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHL1 GNA14 CPXM2 TPP1 TNFAIP8

3.48e-051878859c1013720c248ef201d010806b6e7ad24205e8ee
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 SLC12A3 KCNIP4 NR3C2 SEPTIN10

3.48e-0518788577886f99c229610abd28c4c370d2c7d1536c9782
ToppCellCOVID-19-kidney|COVID-19 / Disease (COVID-19 only), tissue and cell type

DPP6 SLC12A1 FARP1 KCNIP4 DSCAML1

3.48e-05187885d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 FARP1 SYNE1 TNFAIP8 DSCAML1

3.57e-0518888563a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellfacs-Skin-Telogen-3m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHL1 GNA14 CPXM2 TPP1 TNFAIP8

3.57e-051888858cc927b4c51d982fdafa04dc7393617ad9bb220e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 SLC12A3 CPXM2 KCNIP4 NR3C2

3.66e-05189885f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 FARP1 SYNE1 KCNIP4 NR3C2

3.66e-05189885830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 SLC12A3 CPXM2 KCNIP4 NR3C2

3.76e-05190885b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CHL1 DSCAM NRXN2 ATRNL1 DSCAML1

3.76e-051908856c7e1086c0a274cd5527c3104106e372811c9905
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 TBC1D8 SLC12A1 KCNIP4 ADGRF1

3.85e-051918852fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CCND3 CHL1 SLC12A1 KCNIP4 ADGRF1

3.85e-051918855a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CCND3 CHL1 SLC12A1 KCNIP4 ADGRF1

3.85e-0519188555ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TBC1D8 GNA14 SYNE1 NLRP1 BTNL9

4.05e-05193885456aa8a8f1f9cbba0bd618a5f623909079c0f56b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TBC1D8 GNA14 SYNE1 NLRP1 BTNL9

4.25e-0519588523ced69fd904f1d4114b1a7f99f4b5f65ea8824b
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CHL1 DPP6 DSCAM ATRNL1 SYNE1

4.68e-05199885333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CHL1 DPP6 DSCAM ATRNL1 SYNE1

4.68e-0519988519a97e27a4758e794ce7246d295e112b47931a48
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CHL1 DPP6 DSCAM ATRNL1 SYNE1

4.68e-05199885e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

CHL1 DPP6 DSCAM ATRNL1 KCNIP4

4.79e-05200885f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

CHL1 DPP6 DSCAM ATRNL1 KCNIP4

4.79e-05200885cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

CHL1 DPP6 DSCAM ATRNL1 KCNIP4

4.79e-05200885c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

CHL1 DPP6 DSCAM ATRNL1 KCNIP4

4.79e-052008854fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

CHL1 DPP6 DSCAM ATRNL1 KCNIP4

4.79e-05200885310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

CHL1 DPP6 DSCAM ATRNL1 KCNIP4

4.79e-05200885961858738ce35db8760c8c2e136f8369bc444ccf
Diseaseisolated growth hormone deficiency type II (implicated_via_orthology)

CSH1 CSH2 CSHL1

2.47e-075873DOID:0060872 (implicated_via_orthology)
Diseaseisolated growth hormone deficiency (implicated_via_orthology)

CSH1 CSH2 CSHL1

8.59e-077873DOID:0060870 (implicated_via_orthology)
Diseasecongenital hypothyroidism (biomarker_via_orthology)

CSH1 CSH2 CSHL1

8.80e-0614873DOID:0050328 (biomarker_via_orthology)
Diseaseblood 4-oxo-retinoic acid measurement

UGT1A10 UGT1A8

2.57e-053872EFO_0022216
Diseaseindole-3-carboxylate measurement

UGT1A10 UGT1A8

2.57e-053872EFO_0800043
Diseaseosteoporosis (biomarker_via_orthology)

CSH1 CSH2 CSHL1

3.66e-0522873DOID:11476 (biomarker_via_orthology)
Diseasetype 2 diabetes mellitus (biomarker_via_orthology)

CSH1 CSH2 CSHL1 UGT1A10 UGT1A8

7.63e-05147875DOID:9352 (biomarker_via_orthology)
DiseaseN-acetyl-4-chlorophenylalanine measurement

UGT1A10 UGT1A8

8.54e-055872EFO_0801060
Disease5-hydroxyindole sulfate measurement

UGT1A10 UGT1A8

8.54e-055872EFO_0800085
Diseasenuclear receptor subfamily 1 group D member 2 measurement

UGT1A10 UGT1A8

8.54e-055872EFO_0801853
Disease3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-CMPFP) measurement

UGT1A10 UGT1A8

1.28e-046872EFO_0800566
DiseaseX-21339 measurement

UGT1A10 UGT1A8

1.79e-047872EFO_0800808
Diseasetype 1 diabetes mellitus (implicated_via_orthology)

CSH1 CSH2 CSHL1

2.10e-0439873DOID:9744 (implicated_via_orthology)
DiseaseX-11793--oxidized bilirubin measurement

UGT1A10 UGT1A8

2.38e-048872EFO_0021260
DiseaseSuccinimide measurement

UGT1A10 UGT1A8

2.38e-048872EFO_0022118
DiseaseX-11530 measurement

UGT1A10 UGT1A8

2.38e-048872EFO_0021249
Diseasesulfate of piperine metabolite C16H19NO3 (2) measurement

UGT1A10 UGT1A8

2.38e-048872EFO_0801034
Diseasecholelithiasis, bilirubin measurement

UGT1A10 UGT1A8

2.38e-048872EFO_0004570, EFO_0004799
DiseaseX-11522 measurement

UGT1A10 UGT1A8

2.38e-048872EFO_0800696
DiseaseX-10458 measurement

UGT1A10 UGT1A8

2.38e-048872EFO_0800692
DiseaseX-24849 measurement

UGT1A10 UGT1A8

2.38e-048872EFO_0800909
Diseaseserum N-desmethylclozapine measurement

UGT1A10 UGT1A8

2.38e-048872EFO_0600043
Diseaseplasma clozapine measurement

UGT1A10 UGT1A8

2.38e-048872EFO_0600038
Diseasemembrane-associated progesterone receptor component 1 measurement

UGT1A10 UGT1A8

2.38e-048872EFO_0802740
DiseaseX-16946 measurement

UGT1A10 UGT1A8

2.38e-048872EFO_0800766
DiseaseX-11442 measurement

UGT1A10 UGT1A8

3.05e-049872EFO_0021236
DiseaseX-11441 measurement

UGT1A10 UGT1A8

3.05e-049872EFO_0021235
Diseasecirculating cell free DNA measurement

UGT1A10 UGT1A8

3.05e-049872EFO_0004739
Diseasesulfate of piperine metabolite C18H21NO3 (3) measurement

UGT1A10 UGT1A8

3.05e-049872EFO_0801037
Diseasetestis-specific chromodomain protein Y 1 measurement

UGT1A10 UGT1A8

3.05e-049872EFO_0802127
Diseasesulfate of piperine metabolite C18H21NO3 (1) measurement

UGT1A10 UGT1A8

3.05e-049872EFO_0801036
DiseaseX-11880 measurement

UGT1A10 UGT1A8

3.05e-049872EFO_0800698
Diseasebilirubin measurement, response to xenobiotic stimulus

UGT1A10 UGT1A8

3.05e-049872EFO_0004570, GO_0009410
Diseaseprotein-tyrosine kinase 6 measurement

UGT1A10 UGT1A8

3.05e-049872EFO_0020691
DiseaseIntellectual Disability

CHL1 LINS1 AGO1 OR5M1 NRXN2 TPP1 SYNE1

3.60e-04447877C3714756
Diseaseindoleacetate measurement

UGT1A10 UGT1A8

3.81e-0410872EFO_0021015
DiseaseX-21448 measurement

UGT1A10 UGT1A8

3.81e-0410872EFO_0800816
DiseaseUDP-glucuronosyltransferase 1-6 measurement

UGT1A10 UGT1A8

3.81e-0410872EFO_0802185
DiseaseX-23974 measurement

UGT1A10 UGT1A8

3.81e-0410872EFO_0800867
Diseasebilirubin measurement, response to tenofovir

UGT1A10 UGT1A8

3.81e-0410872EFO_0004570, EFO_0009279
Diseasesmoking status measurement, carotid artery intima media thickness

TBC1D8 DPP6 KIF2B

3.89e-0448873EFO_0006527, EFO_0007117
DiseaseX-21796 measurement

UGT1A10 UGT1A8

4.65e-0411872EFO_0800825
Diseasepregnenetriol sulfate measurement

UGT1A10 UGT1A8

4.65e-0411872EFO_0800586
Diseaseplasma N-desmethylclozapine measurement

UGT1A10 UGT1A8

4.65e-0411872EFO_0600039
Diseaseinsomnia, bilirubin measurement

UGT1A10 UGT1A8

4.65e-0411872EFO_0004570, EFO_0004698
Diseasehistidine betaine (hercynine) measurement

UGT1A10 UGT1A8

4.65e-0411872EFO_0800972
Diseasealdosterone measurement

UGT1A10 UGT1A8

4.65e-0411872EFO_0010219
Diseasebiliverdin measurement

UGT1A10 UGT1A8

5.56e-0412872EFO_0021033
Diseasedodecanedioate measurement

UGT1A10 UGT1A8

5.56e-0412872EFO_0021054
Diseasep-cresol glucuronide measurement

UGT1A10 UGT1A8

5.56e-0412872EFO_0800079
DiseaseX-24588 measurement

UGT1A10 UGT1A8

6.56e-0413872EFO_0800898
Diseaseretinol dehydrogenase 16 measurement

UGT1A10 UGT1A8

6.56e-0413872EFO_0802007
Diseasepregnenetriol disulfate measurement

UGT1A10 UGT1A8

6.56e-0413872EFO_0800587
DiseaseDown syndrome (implicated_via_orthology)

DSCAM DSCAML1

8.80e-0415872DOID:14250 (implicated_via_orthology)
Diseaseposterior thigh muscle volume

CSH1 CSHL1

8.80e-0415872EFO_0020931
DiseaseRolandic epilepsy

PTCHD3 NR3C2

1.00e-0316872Orphanet_1945
Diseaseautism spectrum disorder (implicated_via_orthology)

DSCAM NRXN2 NR3C2 DSCAML1

1.08e-03152874DOID:0060041 (implicated_via_orthology)
DiseaseX-21441 measurement

UGT1A10 UGT1A8

1.14e-0317872EFO_0800814
Diseaselow density lipoprotein cholesterol measurement, body fat percentage

UGT1A10 UGT1A8

1.14e-0317872EFO_0004611, EFO_0007800
Diseaseangiopoietin-related protein 1 measurement

UGT1A10 UGT1A8

1.28e-0318872EFO_0801382
Diseasetissue factor measurement

UGT1A10 UGT1A8

1.74e-0321872EFO_0010623
Diseaseurate measurement, bone density

DSCAM SULF1 UGT1A10 UGT1A8 SYNE1 NR3C2 SEPTIN10

2.37e-03619877EFO_0003923, EFO_0004531

Protein segments in the cluster

PeptideGeneStartEntry
TAHFEDLEQCYFSTR

COP1

361

Q8NHY2
APEACFSFHSSYERN

LINC00308

36

Q8TCZ7
EAFFSFCSSNHLEYL

SLC4A2

776

P04920
IFTFHDTFSGALCAY

BTNL9

471

Q6UXG8
HAQTFLALCATDYTF

CCND3

181

P30281
SDFSIHEFLATCQDY

BRD7

441

Q9NPI1
VCTAAVFFTHFFYLS

ADGRF1

656

Q5T601
SCALSFFLFSFQVHE

ALG6

331

Q9Y672
FSNCSFEDFAHFISK

ADAM2

351

Q99965
TNITHPFEFDFYLCS

AGO1

736

Q9UL18
QKYSFLHDSQTSFCF

CSHL1

71

Q14406
SAADFFSHYEYLCAL

CEP78

11

Q5JTW2
SEAFSQLYNPSFDCH

AHDC1

1121

Q5TGY3
AGSLNDFSYLHTNCF

CPXM2

591

Q8N436
FFLGHLSFVDICYSS

OR5M10

61

Q6IEU7
DGYFRLTTDSQHFFC

JAK3

346

P52333
NHLSFVDFCYSSIIA

OR5D16

66

Q8NGK9
FFLSHLSFCDLCYST

OR5W2

61

Q8NH69
FFLSHLSLLDACYTS

OR9I1

61

Q8NGQ6
FFLSNLAFVDFCYSS

OR8U8

61

P0C7N1
YFLSSLSFIDFCHST

OR8G1

61

Q15617
ISFHSCVAQLYFFHF

OR10G7

91

Q8NGN6
CVAQLYFFHFLGSTE

OR10G7

96

Q8NGN6
ISFHSCVAQLYFFHF

OR10G4

91

Q8NGN3
CVAQLYFFHFLGSTE

OR10G4

96

Q8NGN3
VFYNSLFSQHFENCR

LINS1

226

Q8NG48
SDLLEFCFYTFRESH

NR3C2

936

P08235
VVGYSAFLHCEFFAS

CHL1

436

O00533
KFSCFFHYAVDNLGA

TRMU

106

O75648
FFCFNFLKHITSEEF

MTMR14

391

Q8NCE2
EQFKSAFSCFHYSTE

CHCHD4

66

Q8N4Q1
QKYSFLHDSQTSFCF

CSH2

66

P0DML3
ASACYAQLFFIHTFT

OR51L1

96

Q8NGJ5
ISYDACLSQLFFFHL

OR3A2

101

P47893
SEACFAQFFFLHGFS

OR51Q1

96

Q8NH59
ISYDACLSQLFFFHL

OR3A3

101

P47888
FQHVFYFSCRELAQS

NLRP1

361

Q9C000
STTYAHFLFNAFDTD

KCNIP4

121

Q6PIL6
TFKGNEFFCYDLSHN

NRXN2

291

Q9P2S2
TFFHLSLQDFCAALY

NLRP5

581

P59047
DCFNLFETGFYHSEL

MIER3

451

Q7Z3K6
YFFLSNLSFLDLCHT

OR2J2

61

O76002
FFSSCELVEFHYSLF

DDX31

516

Q9H8H2
TDLRSFYAESCFLFA

FOXRED2

591

Q8IWF2
FFLSNLAFVDFCYSS

OR8U9

61

P0C7N5
TLFCSSEISFDQYHL

KIR3DX1

241

Q9H7L2
YFLLAHLSFADLCFA

OR1K1

61

Q8NGR3
SLSENDTHCVQFSYF

PTPRU

91

Q92729
CKFIRFSFHFNLYSS

OXGR1

106

Q96P68
FFLQHLAFVDICYTS

OR5AK2

61

Q8NH90
FKQAEEYLSFAFEHC

PCID2

226

Q5JVF3
FDLCALANDHDLYFL

CCNYL3

181

P0C7X3
LEDSCFHYGFNSNYL

EPHX1

76

P07099
FHYLDFSFCSTRCLQ

ANKZF1

701

Q9H8Y5
FSDIDFFPNAVYTHC

DCAF12

411

Q5T6F0
FTNFCLFFYKSHQDN

FARP1

956

Q9Y4F1
AFNSFIHDNDYFCTA

DSCAML1

91

Q8TD84
SEFSSCLADQHLYFS

FASTKD1

156

Q53R41
YALLHFFSDAAYNLT

ATRNL1

186

Q5VV63
FFRQIVSALDFCHSY

BRSK1

136

Q8TDC3
HNAEERYDAFCFTSN

HAPLN4

256

Q86UW8
AYAASKHATQAFFDC

DHRS7B

206

Q6IAN0
DLVENCTYFSASFSH

DPP6

531

P42658
QKYSFLHDSQTSFCF

CSH1

66

P0DML2
TRYLQNQTFCFDHAF

KIF2B

256

Q8N4N8
CIGFSFDFSVHISYA

PTCHD3

861

Q3KNS1
ISFHSCVAQLYFFHF

OR10G9

91

Q8NGN4
CVAQLYFFHFLGSTE

OR10G9

96

Q8NGN4
FFFSNLSFLDLCYTT

OR2B8P

61

P59922
QFTFRKSNSLDHFYC

OR9A2

161

Q8NGT5
FFLSNLAFVDFCYSS

OR8U1

61

Q8NH10
YFLSSLSFIDFCHST

OR8G3P

61

P0DMU2
SFANVFSEDLHSSLY

DSCAM

11

O60469
FSEDLHSSLYFVNAS

DSCAM

16

O60469
YSHFTCATDTDNIRF

GNA14

321

O95837
FQHSQDVSDCYLELF

PLEKHN1

106

Q494U1
DYSCALSNNFARSFH

SYNE1

8771

Q8NF91
DYRIRFSSLCFFNDH

PUS7L

6

Q9H0K6
FFLSHLSSVDFCYSS

OR5L1

61

Q8NGL2
FFLGHLSFVDICYSS

OR5M1

61

Q8NGP8
LASYALINFSCFHAS

SLC12A1

576

Q13621
HFSDCEFLAALYNPF

TNFAIP8

161

O95379
FFLSHLSFVDFCYSS

OR5L2

61

Q8NGL0
AFSYLDSFQSHDKAC

ZNF20

151

P17024
QAIFYSFFHLSFACA

UNC93B1

221

Q9H1C4
FLDLFFSHCRSLFND

UGT1A10

116

Q9HAW8
SINHLCFYSFFLGKE

TBC1D8

181

O95759
AFASFYLAGKLHCFT

PLPP5

161

Q8NEB5
FCALVHSFFPDAFDY

SMTNL2

386

Q2TAL5
FEYFANSQFHDCSDH

SENP8

36

Q96LD8
FLCSYALINFSCFHA

SLC12A3

536

P55017
LFNTNFEDYESSHFC

SEPTIN10

86

Q9P0V9
YSFFHCADPSASRLE

PITPNM3

431

Q9BZ71
ENIFSETAFHSACTY

TNNI3K

301

Q59H18
HNFLFCEFATGFLEY

SULF1

786

Q8IWU6
RHFFTSWASCLQYDF

WDFY1

151

Q8IWB7
FFNLFFSHCRSLFND

UGT1A8

116

Q9HAW9
ACAQFLEQYFHDSDL

TPP1

226

O14773