Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Cyclin_Y	CCNY CCNYL1	3.76e-05	2	115	2	IPR012399
Pathway	WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION	PDE2A GRIN2B ADCY3 PDE8B NOS1	2.43e-05	55	89	5	M39763
Pubmed	Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.	FLT3 JAK1 JAK2	1.29e-06	7	117	3	18270328
Pubmed	The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons.	JAK1 JAK2 HSP90AA1	3.07e-06	9	117	3	16280321
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PDE2A USP9X UBR4 TSC2 GRIN2B PREPL FRY NCAN PLEKHA5 EXOG RIMS1 NOS1 AFF4 HSP90AA1	4.64e-06	963	117	14	28671696
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PDE2A USP9X UBR4 TSC2 GRIN2B USP9Y TF PREPL DSCAML1 DMAP1 JAK1 FRY ZNF451 ZNF841 AFF4 HSP90AA1	6.63e-06	1285	117	16	35914814
Pubmed	Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin.	NEB RBM20	1.12e-05	2	117	2	27139341
Pubmed	Anti-myeloma effects of ruxolitinib combined with bortezomib and lenalidomide: A rationale for JAK/STAT pathway inhibition in myeloma patients.	JAK1 JAK2	1.12e-05	2	117	2	28645562
Pubmed	MS-275, a novel histone deacetylase inhibitor with selectivity against HDAC1, induces degradation of FLT3 via inhibition of chaperone function of heat shock protein 90 in AML cells.	FLT3 HSP90AA1	1.12e-05	2	117	2	18394702
Pubmed	Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation.	JAK1 JAK2	1.12e-05	2	117	2	24169825
Pubmed	Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1A-mediated microtubule interaction and M-phase cell cycle regulation.	AURKA RASSF1	1.12e-05	2	117	2	17563743
Pubmed	JAK2V617F mutation as a marker of a latent myeloproliferative disorder in a patient with Budd-Chiari syndrome and factor V Leiden mutation.	F5 JAK2	1.12e-05	2	117	2	17849060
Pubmed	SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression.	POLRMT SUCLG1	1.12e-05	2	117	2	38649537
Pubmed	Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors.	JAK1 JAK2	1.12e-05	2	117	2	21393331
Pubmed	Pharmacologic Inhibition of JAK1/JAK2 Signaling Reduces Experimental Murine Acute GVHD While Preserving GVT Effects.	JAK1 JAK2	1.12e-05	2	117	2	25977345
Pubmed	The Janus kinases inhibitor AZD1480 attenuates growth of small cell lung cancers in vitro and in vivo.	JAK1 JAK2	1.12e-05	2	117	2	24158701
Pubmed	Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C.	F5 PROS1	1.12e-05	2	117	2	8428962
Pubmed	Low expression of PTEN is essential for maintenance of a malignant state in human gastric adenocarcinoma via upregulation of p‑AURKA mediated by activation of AURKA.	PTEN AURKA	1.12e-05	2	117	2	29512701
Pubmed	Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation.	F5 PROS1	1.12e-05	2	117	2	26251307
Pubmed	Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.	USP9X USP9Y	1.12e-05	2	117	2	12895410
Pubmed	Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation.	JAK2 AURKA	1.12e-05	2	117	2	24930769
Pubmed	Plasma protein S residues 37-50 mediate its binding to factor Va and inhibition of blood coagulation.	F5 PROS1	1.12e-05	2	117	2	23892573
Pubmed	SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation.	JAK1 JAK2	1.12e-05	2	117	2	33827897
Pubmed	Negative regulation of neurogenesis and spatial memory by NR2B-containing NMDA receptors.	GRIN2B NOS1	1.12e-05	2	117	2	18624924
Pubmed	The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit.	ELL2 AFF4	1.12e-05	2	117	2	21242887
Pubmed	[JAK2-V617F mutation in patients with myeloproliferative neoplasms: association with FLT3-ITD mutation].	FLT3 JAK2	1.12e-05	2	117	2	21180092
Pubmed	Heat-shock protein 90 augments neuronal nitric oxide synthase activity by enhancing Ca2+/calmodulin binding.	NOS1 HSP90AA1	1.12e-05	2	117	2	11284722
Pubmed	Ruxolitinib + capecitabine in advanced/metastatic pancreatic cancer after disease progression/intolerance to first-line therapy: JANUS 1 and 2 randomized phase III studies.	JAK1 JAK2	1.12e-05	2	117	2	29508247
Pubmed	Neuron-restrictive silencer factor regulates the N-methyl-D-aspartate receptor 2B subunit gene in basal and ethanol-induced gene expression in fetal cortical neurons.	GRIN2B REST	1.12e-05	2	117	2	15755907
Pubmed	Gene diversity for haptoglobin and transferrin classical markers among Hindu and Muslim populations of Aligarh City, India.	TF HP	1.12e-05	2	117	2	21866866
Pubmed	Direct and indirect consequences on gene expression of a thyroid hormone receptor alpha 1 mutation restricted to Sertoli cells.	THRA PLEKHA5	1.12e-05	2	117	2	25487743
Pubmed	Therapeutic effect of JAK1/2 blockade on the manifestations of hemophagocytic lymphohistiocytosis in mice.	JAK1 JAK2	1.12e-05	2	117	2	27222478
Pubmed	Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.	JAK1 JAK2	1.12e-05	2	117	2	27903500
Pubmed	Two members of the JAK family of protein tyrosine kinases map to chromosomes 1p31.3 and 9p24.	JAK1 JAK2	1.12e-05	2	117	2	1581631
Pubmed	The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.	USP9X USP9Y	1.12e-05	2	117	2	8922996
Pubmed	PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth.	TSC2 PTEN	1.12e-05	2	117	2	19395652
Pubmed	Combined inhibition of Janus kinase 1/2 for the treatment of JAK2V617F-driven neoplasms: selective effects on mutant cells and improvements in measures of disease severity.	JAK1 JAK2	1.12e-05	2	117	2	19887489
Pubmed	Ruxolitinib suppresses liver fibrosis progression and accelerates fibrosis reversal via selectively targeting Janus kinase 1/2.	JAK1 JAK2	1.12e-05	2	117	2	35382859
Pubmed	FLT3 and JAK2 Mutations in Acute Myeloid Leukemia Promote Interchromosomal Homologous Recombination and the Potential for Copy Neutral Loss of Heterozygosity.	FLT3 JAK2	1.12e-05	2	117	2	28108507
Pubmed	The roles of factor Va and protein S in formation of the activated protein C/protein S/factor Va inactivation complex.	F5 PROS1	1.12e-05	2	117	2	31364267
Pubmed	Thyroid hormone limits postnatal Sertoli cell proliferation in vivo by activation of its alpha1 isoform receptor (TRalpha1) present in these cells and by regulation of Cdk4/JunD/c-myc mRNA levels in mice.	THRA PLEKHA5	1.12e-05	2	117	2	22539677
Pubmed	Neuronal nitric-oxide synthase is regulated by the Hsp90-based chaperone system in vivo.	NOS1 HSP90AA1	1.12e-05	2	117	2	9880522
Pubmed	Absence of FLT3 and JAK2 (V617F) mutations in Langerhans cell histiocytosis.	FLT3 JAK2	1.12e-05	2	117	2	19395028
Pubmed	C-terminal residues 621-635 of protein S are essential for binding to factor Va.	F5 PROS1	1.12e-05	2	117	2	10593904
Pubmed	New type of interaction between the SARAH domain of the tumour suppressor RASSF1A and its mitotic kinase Aurora A.	AURKA RASSF1	1.12e-05	2	117	2	30944388
Pubmed	Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription.	ELL2 AFF4	1.12e-05	2	117	2	28134250
Pubmed	Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.	USP9X USP9Y	1.12e-05	2	117	2	12925892
Pubmed	Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells.	JAK1 JAK2	1.12e-05	2	117	2	22684105
Pubmed	The alteration of RhoA geranylgeranylation and Ras farnesylation breaks the integrity of the blood-testis barrier and results in hypospermatogenesis.	PLEKHA5 GGPS1	1.12e-05	2	117	2	31171774
Pubmed	RASSF1A interacts with and activates the mitotic kinase Aurora-A.	AURKA RASSF1	1.12e-05	2	117	2	18641684
Pubmed	Negative regulation of REST on NR2B in spinal cord contributes to the development of bone cancer pain in mice.	GRIN2B REST	1.12e-05	2	117	2	27732941
Pubmed	Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.	JAK1 JAK2	1.12e-05	2	117	2	1848670
Pubmed	Targeting oncoprotein stability overcomes drug resistance caused by FLT3 kinase domain mutations.	FLT3 HSP90AA1	1.12e-05	2	117	2	24849514
Pubmed	Preclinical evaluation of JAK1/2 inhibition by ruxolitinib in a murine model of chronic graft-versus-host disease.	JAK1 JAK2	1.12e-05	2	117	2	33811972
Pubmed	PTEN deficiency induces an extrahepatic cholangitis-cholangiocarcinoma continuum via aurora kinase A in mice.	PTEN AURKA	1.12e-05	2	117	2	38428643
Pubmed	Long-term efficacy and safety of momelotinib, a JAK1 and JAK2 inhibitor, for the treatment of myelofibrosis.	JAK1 JAK2	1.12e-05	2	117	2	29263442
Pubmed	Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection.	PLEKHA5 GGPS1	1.12e-05	2	117	2	23825187
Pubmed	Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression.	TSC2 PTEN	1.12e-05	2	117	2	16027168
Pubmed	CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia.	FLT3 PTEN JAK1 JAK2 VAV2	1.17e-05	87	117	5	29991678
Pubmed	A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias.	FLT3 JAK1 JAK2	2.01e-05	16	117	3	19464057
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	USP9X USP9Y UTY	2.92e-05	18	117	3	12023983
Pubmed	PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain.	GRIN2B NOS1	3.36e-05	3	117	2	10488080
Pubmed	Frequency and prognostic implications of JAK 1-3 aberrations in Down syndrome acute lymphoblastic and myeloid leukemia.	JAK1 JAK2	3.36e-05	3	117	2	21537335
Pubmed	The interaction between RE1-silencing transcription factor (REST) and heat shock protein 90 as new therapeutic target against Huntington's disease.	REST HSP90AA1	3.36e-05	3	117	2	31361762
Pubmed	Genetic variants of Y chromosome are associated with a protective lipid profile in black men.	USP9Y UTY	3.36e-05	3	117	2	18511697
Pubmed	Progesterone activates Janus Kinase 1/2 and activators of transcription 1 (JAK1-2/STAT1) pathway in human spermatozoa.	JAK1 JAK2	3.36e-05	3	117	2	22748021
Pubmed	Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.	JAK1 JAK2	3.36e-05	3	117	2	17550976
Pubmed	Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase.	JAK1 JAK2	3.36e-05	3	117	2	9548458
Pubmed	New real-time PCR-based method for the joint genotyping of JAK2 (V617F) with inherited thrombophilic F5 and F2 mutations.	F5 JAK2	3.36e-05	3	117	2	19778528
Pubmed	Novel APC-cleavage sites in FVa provide insights into mechanisms of action of APC and its cofactor protein S.	F5 PROS1	3.36e-05	3	117	2	19874463
Pubmed	Structural organization and chromosomal mapping of JAK3 locus.	JAK1 JAK2	3.36e-05	3	117	2	8934548
Pubmed	Foot-and-mouth disease virus structural protein VP3 degrades Janus kinase 1 to inhibit IFN-γ signal transduction pathways.	JAK1 JAK2	3.36e-05	3	117	2	26901336
Pubmed	Nitric oxide is an activity-dependent regulator of target neuron intrinsic excitability.	KCNB2 NOS1	3.36e-05	3	117	2	21791288
Pubmed	AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers.	JAK2 AURKA	3.36e-05	3	117	2	24953013
Pubmed	Gain-of-function gene mutations and venous thromboembolism: distinct roles in different clinical settings.	F5 JAK2	3.36e-05	3	117	2	17307838
Pubmed	Induction of Jak/STAT signaling by activation of the type 1 TNF receptor.	JAK1 JAK2	3.36e-05	3	117	2	9510175
Pubmed	Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis.	CCNY CCNYL1	3.36e-05	3	117	2	22184064
Pubmed	Signal transduction by the atopy-associated human thymic stromal lymphopoietin (TSLP) receptor depends on Janus kinase function.	JAK1 JAK2	3.36e-05	3	117	2	20128689
Pubmed	Implication of JAK1, JAK2, and JAK3 in the Realization of Proliferation and Differentiation Potential of Mesenchymal Progenitor Cells In Vitro.	JAK1 JAK2	3.36e-05	3	117	2	27383175
Pubmed	eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer.	PTEN AURKA	3.36e-05	3	117	2	38442201
Pubmed	Age-associated inflammation inhibits epidermal stem cell function.	JAK1 JAK2	3.36e-05	3	117	2	22972935
Pubmed	Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children.	JAK1 JAK2	3.36e-05	3	117	2	27554814
Pubmed	Immunohistochemically Detected Expression of ATRX, TSC2, and PTEN Predicts Clinical Outcomes in Patients With Grade 1 and 2 Pancreatic Neuroendocrine Tumors.	TSC2 PTEN	3.36e-05	3	117	2	31599805
Pubmed	LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease.	JAK1 JAK2	3.36e-05	3	117	2	21151131
Pubmed	A preliminary study of new single polymorphisms in the T helper type 17 pathway for psoriasis in the Korean population.	JAK1 JAK2	3.36e-05	3	117	2	27774581
Pubmed	Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.	JAK1 JAK2	3.36e-05	3	117	2	8272873
Pubmed	The JAK1/2 Inhibitor Ruxolitinib Reverses Interleukin-6-Mediated Suppression of Drug-Detoxifying Proteins in Cultured Human Hepatocytes.	JAK1 JAK2	3.36e-05	3	117	2	29162613
Pubmed	Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.	JAK1 JAK2	3.36e-05	3	117	2	8378315
Pubmed	CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse.	CCNY CCNYL1	3.36e-05	3	117	2	26305884
Pubmed	Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia.	PHF6 JAK1	3.36e-05	3	117	2	21880637
Pubmed	mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells.	TSC2 PTEN	3.36e-05	3	117	2	28484008
Pubmed	Thrombin generation and activated protein C resistance in patients with essential thrombocythemia and polycythemia vera.	JAK2 PROS1	3.36e-05	3	117	2	18768782
Pubmed	Detection of FLT3/ITD, JAK2(V617F) and NPM1 gene mutations in chronic myelomonocytic leukemia.	FLT3 JAK2	3.36e-05	3	117	2	19540590
Pubmed	Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers.	PTEN HSP90AA1	3.36e-05	3	117	2	20226014
Pubmed	INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support.	JAK1 JAK2	3.36e-05	3	117	2	20072651
Pubmed	The effect of occupational lead exposure on blood levels of zinc, iron, copper, selenium and related proteins.	TF HP	3.36e-05	3	117	2	22923205
Pubmed	Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma.	MYO10 PTEN	3.36e-05	3	117	2	33299973
Pubmed	YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling.	JAK1 JAK2	3.36e-05	3	117	2	12551917
Pubmed	Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells.	JAK1 JAK2	3.36e-05	3	117	2	15923602
Pubmed	A novel functional assay of protein C in human plasma and its comparison with amidolytic and anticoagulant assays.	F5 PROS1	3.36e-05	3	117	2	1615482
Pubmed	Piperlongumine inhibits gastric cancer cells via suppression of the JAK1,2/STAT3 signaling pathway.	JAK1 JAK2	3.36e-05	3	117	2	27053336
Pubmed	Prevalence of the JAK2 V617F mutation in patients with unprovoked venous thromboembolism of common sites and without overt myeloproliferative neoplasms.	F5 JAK2	3.36e-05	3	117	2	19120368
Interaction	CALM1 interactions	MYO10 UBR4 POLRMT TSC2 RDH13 GRIN2B NEB PTEN JAK2 VPS13D ZNF451 ASPM PLEKHA5 PPIL2 PEAK1 HSP90AA1	5.38e-07	626	115	16	int:CALM1
Cytoband	2q33.3	FASTKD2 INO80D CCNYL1	6.23e-05	30	117	3	2q33.3
Cytoband	12p12	GRIN2B PLEKHA5	4.93e-04	13	117	2	12p12
Cytoband	20q13	CYP24A1 AURKA	6.62e-04	15	117	2	20q13
GeneFamily	AF4/FMR2 family\|Super elongation complex	ELL2 AFF4	8.06e-04	9	87	2	1280
GeneFamily	Olfactory receptors, family 51	OR51A4 OR51A2 OR51A7	1.24e-03	44	87	3	164
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	MYO10 JAK1 JAK2	1.79e-03	50	87	3	1293
Coexpression	GSE25085_FETAL_BM_VS_ADULT_BM_SP4_THYMIC_IMPLANT_DN	TTC39B STAB2 MYO10 SLCO3A1 CCNYL1 HP PLD2 ADGRL2	3.22e-06	199	117	8	M8070
Coexpression	GSE2935_UV_INACTIVATED_VS_LIVE_SENDAI_VIRUS_INF_MACROPHAGE_DN	TTC39B PDE2A ELL2 GVINP1 EBPL PPIL2 POGLUT2	1.68e-05	180	117	7	M6317
Coexpression	GSE360_T_GONDII_VS_B_MALAYI_LOW_DOSE_MAC_UP	HMGCS2 KCNB2 THRA RASSF1 HS2ST1 ATAD2B ALDOB	2.91e-05	196	117	7	M5256
Coexpression	GSE9960_GRAM_POS_VS_GRAM_NEG_AND_POS_SEPSIS_PBMC_DN	UBR4 GRIN2B PTEN HP DDX25 ZNF841 UTY	3.31e-05	200	117	7	M7133
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	ABCA3 SLCO3A1 TSC2 NEB PTEN PREPL DSCAML1 TBC1D32 FRY THRA NALF1 NCAN RIMS1 CATSPERG MAB21L1 VAV2	3.33e-05	1106	117	16	M39071
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GRIN2B SIM1 USP9Y NEB F5 PKHD1 KLKB1 DNAH9	1.08e-08	162	116	8	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A STAB2 MYO10 SNRK JAK1 PEAK1 ADGRL2 PROS1	4.97e-08	197	116	8	deefb492b5f0e6014144bd465c4a6ae4206e8739
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A STAB2 MYO10 SNRK JAK1 PEAK1 ADGRL2 PROS1	4.97e-08	197	116	8	a6aaa6faea348291023f0bc4b0f83fbc67d91da6
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2B KCNB2 PREPL FRY NALF1 PLEKHA5 RIMS1 ADGRL2	5.17e-08	198	116	8	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	GRIN2B KCNB2 PREPL FRY NALF1 PLEKHA5 RIMS1 ADGRL2	5.58e-08	200	116	8	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 GRIN2B PKD1L2 NEB DSCAML1 PKHD1 DNAH9	5.47e-07	184	116	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 GRIN2B PKD1L2 NEB DSCAML1 PKHD1 DNAH9	5.47e-07	184	116	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 GRIN2B PKD1L2 NEB DSCAML1 PKHD1 DNAH9	5.47e-07	184	116	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	HMGCS2 TF DSCAML1 ELL2 PKHD1 PLEKHA5 VAV2	5.67e-07	185	116	7	1d874608aa2062024323512f68889219471b2f00
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	MYO10 SLCO3A1 SNRK SIM1 FRY PKHD1 UTY	6.54e-07	189	116	7	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	human_hepatoblastoma-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	HMGCS2 SUCLG1 F5 TF DSCAML1 ELL2 KLKB1	7.27e-07	192	116	7	e785135262f4c9cc66c403bf362bb34643b212c5
ToppCell	background-Endothelial_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	PDE2A STAB2 SLCO3A1 INO80D HP ADGRL2 ALDOB	8.07e-07	195	116	7	c7d60dabfc7cb310e002cab10003dadfcc34fe33
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2B KCNB2 FRY NALF1 PLEKHA5 RIMS1 ADGRL2	8.35e-07	196	116	7	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2B PREPL FRY NALF1 PLEKHA5 RIMS1 ADGRL2	8.94e-07	198	116	7	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2B PREPL FRY NALF1 PLEKHA5 RIMS1 ADGRL2	8.94e-07	198	116	7	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A STAB2 MYO10 SNRK PEAK1 ADGRL2 PROS1	8.94e-07	198	116	7	f0f1816a0ed3ae8207442602f5cbe4de0382e4b3
ToppCell	background-Hepatocytes\|background / Sample and Cell Type and Tumor Cluster (all cells)	HMGCS2 F5 TF ELL2 HP ALDOB PROS1	9.56e-07	200	116	7	787d35b5c2f2ad967ae14e99496a0299ac7e72fd
ToppCell	severe-unassigned\|World / disease stage, cell group and cell class	ZNF777 POLR1A LEKR1 INO80D ASPM ZNF841	4.56e-06	164	116	6	b3a45c150df6594debeeca400cc58d30ef662756
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLCO3A1 SNRK KCNB2 DSCAML1 PKHD1 ENOX2	5.60e-06	170	116	6	5d5f208682be21ed58320f5fc083a7898f8712da
ToppCell	droplet-Spleen-SPLEEN-30m-Lymphocytic-mature_NK_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A SLCO3A1 JAK1 CELSR1 PLEKHA5 PEAK1	7.06e-06	177	116	6	52402ff6299210c46fd9dee3cef203c0eda7a98a
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA3 STAB2 CELSR1 KCNF1 VAV2 ENOX2	8.28e-06	182	116	6	f231e86524b628e6e11ac33d5c34be99d454a92a
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NHLRC2 FNDC1 FRY PDE8B ADGRL2 PROS1	1.03e-05	189	116	6	09dd2b3d89416192e84abe302a6237b8f3fdcb6e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF208 HMGCS2 GRIN2B FRY NALF1 PKP3	1.03e-05	189	116	6	bfc76a72b600d641c8fe58346e5d8986c34f3981
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYO10 ZNF208 HMGCS2 GRIN2B FRY NALF1	1.06e-05	190	116	6	b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYO10 ZNF208 HMGCS2 GRIN2B FRY VAV2	1.12e-05	192	116	6	fd08ae787e936cfdb1ab8f19b0fd63005b462709
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HMGCS2 GRIN2B CGRRF1 P2RY14 RIMS1 PROS1	1.12e-05	192	116	6	93903576dddd8227328e4ced75aa7625eedb9baf
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYO10 ZNF208 HMGCS2 GRIN2B FRY VAV2	1.12e-05	192	116	6	bae236c9f1fac77bce28d0a9cf090100d391ff77
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HMGCS2 GRIN2B CGRRF1 P2RY14 RIMS1 PROS1	1.16e-05	193	116	6	cfab88935abe0a15632c5eec8ff00a857ec9b3ed
ToppCell	(1)_Control_(PBS)-(1)_VE-Cad+_vascular_cells\|World / Stress and Cell class	PDE2A STAB2 MYO10 SNRK JAK1 PEAK1	1.23e-05	195	116	6	6b5d3ecec0c00ebfc889dc6235390ff53b5c0b6a
ToppCell	LPS_only-Unknown-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HMGCS2 ADCY3 RBM20 P2RY14 KLF17	1.28e-05	115	116	5	ad5298c2ad8bf94fa13c2e50b0799e929473ef59
ToppCell	LPS_only-Unknown\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HMGCS2 ADCY3 RBM20 P2RY14 KLF17	1.28e-05	115	116	5	7a733f6987b40ec497a03734b79ed5355ad3a2fc
ToppCell	LPS_only-Unknown-Endothelial-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HMGCS2 ADCY3 RBM20 P2RY14 KLF17	1.28e-05	115	116	5	c67145d3cd9243994a141749b426ff2a6dcc8d93
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2B PREPL FRY NALF1 PLEKHA5 RIMS1	1.34e-05	198	116	6	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2B FRY NALF1 PLEKHA5 RIMS1 ADGRL2	1.34e-05	198	116	6	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Serous\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	HMGCS2 ZNF25 HP PKP3 RIMS1 ZNF841	1.41e-05	200	116	6	61bae10c8b12196d9cee766897971b81cb897191
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic-liver_dendritic_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FLT3 PHF7 ZNF677 HS2ST1 VAV2	5.20e-05	154	116	5	acfbde0fbc09fd69af62a81f8f63e14e36dd1ae0
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 FRY GVINP1 ASPM VAV2	5.87e-05	158	116	5	91d265e95156f16459924d3e4dd11c180e164eee
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIN2B DSCAML1 PKHD1 ABCC12 DNAH9	6.23e-05	160	116	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIN2B DSCAML1 PKHD1 ABCC12 DNAH9	6.23e-05	160	116	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	367C-Fibroblasts-Fibroblast-F\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ZNF777 PHF7 KCNB2 ASPM RIMS1	6.42e-05	161	116	5	c61283c301a87bb802f6f8ce79c26067032dd7d9
ToppCell	367C-Fibroblasts-Fibroblast-F-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ZNF777 PHF7 KCNB2 ASPM RIMS1	6.42e-05	161	116	5	9864d8b0929dacf4be7a4e97d2527ac3120ea264
ToppCell	severe-unassigned\|severe / disease stage, cell group and cell class	ZNF777 LEKR1 INO80D PLEKHA5 ZNF841	7.21e-05	165	116	5	f9ddd547992fec065d539a1d0305acba8fc7d79c
ToppCell	Monocytes-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	ZNF777 FLT3 NEB P2RY14	7.23e-05	85	116	4	e73603d6f22bb56159aa5d1a2695775f038e61d8
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KCNB2 F5 DSCAML1 DDX25 RIMS1	7.63e-05	167	116	5	c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell	droplet-Lung-LUNG-30m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 DSCAML1 JAK2 PKP3 VAV2	7.85e-05	168	116	5	0e8b0e6399c6c82c9c0e546f7316f902de0765d3
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 DSCAML1 JAK2 VAV2 ENOX2	9.51e-05	175	116	5	91cb819a1786020713b7e64480de0545380daae9
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLT3 DSCAML1 JAK2 VAV2 ENOX2	1.00e-04	177	116	5	4672cc75225a4a23b298afa8ce439628262519db
ToppCell	facs-Skin-Anagen-24m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH3 DSCAML1 AURKA ASPM VAV2	1.00e-04	177	116	5	8a0f0fbb06cdacb99a3fdba0da3e0494b891db4f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SNRK DSCAML1 CELSR1 PKHD1 ENOX2	1.00e-04	177	116	5	da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SUCLG1 F5 ADCY3 NUDT5 CCR4	1.00e-04	177	116	5	f4ddf0ef0eade13b9835a5684a8dbb6f71be4697
ToppCell	facs-Skin-Anagen-24m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH3 DSCAML1 AURKA ASPM VAV2	1.00e-04	177	116	5	e9d7682517fb30fd2ad535d59779d718a7024c13
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-mature_NK_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A SLCO3A1 JAK1 PLEKHA5 PEAK1	1.00e-04	177	116	5	6561794ae3b14b5279b249eb5e93b80ef15ed82c
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SIM1 USP9Y NALF1 PKHD1 ADGRL2	1.00e-04	177	116	5	c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLCO3A1 NALF1 PLEKHA5 RIMS1 NOS1	1.11e-04	181	116	5	22363c5835dd6cef8f895ab9362e0837d92b15b1
ToppCell	PND10-Immune-Immune_Myeloid-Dendritic-cDC1\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF777 POLR1A PHF6 GVINP1 ASPM	1.17e-04	183	116	5	ab38264daddccdf5ffb75ff2210b27423eca6bc0
ToppCell	PND10-Immune-Immune_Myeloid-Dendritic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF777 POLR1A PHF6 GVINP1 ASPM	1.17e-04	183	116	5	e4911601dca2c0ecb448cdb6b222dedfc0c8bf6c
ToppCell	PND10-Immune-Immune_Myeloid-Dendritic-cDC1-cDC1_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF777 POLR1A PHF6 GVINP1 ASPM	1.17e-04	183	116	5	263bfa1d8a7314bc3156c735c403c3bab8ea4dac
ToppCell	Adult-Mesenchymal-pericyte_cell-D122\|Adult / Lineage, Cell type, age group and donor	MYO10 PTEN ADCY3 P2RY14 ADGRL2	1.17e-04	183	116	5	fc31a43a637423cb3bb9aa184a3a889a0b9aaea6
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	F5 TF HP SEPTIN14 ALDOB	1.20e-04	184	116	5	7ecdf2645e9378cf2f5ce4557f2cf100e6f184ba
ToppCell	COVID-19-Heart-Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	PTEN DSCAML1 ADCY3 P2RY14 RIMS1	1.20e-04	184	116	5	21790cdfa3b4036ad413fd44b94e31563116f25f
ToppCell	COVID-19-kidney-FLT1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE2A SNRK CCNY ELL2 ADGRL2	1.23e-04	185	116	5	673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCell	COVID-19-Fibroblasts-Pericytes\|COVID-19 / group, cell type (main and fine annotations)	PTEN ADCY3 PDE8B P2RY14 ADGRL2	1.23e-04	185	116	5	4905adaeeffd353e089578e5ea614437dbe794e6
ToppCell	wk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TTC39B CELSR1 ELL2 PKHD1 CCR4	1.23e-04	185	116	5	636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP9X UTY AFF4 HSP90AA1 PROS1	1.23e-04	185	116	5	eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYO10 PTEN ADCY3 PDE8B P2RY14	1.27e-04	186	116	5	888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PDE2A ADCY3 RBM20 PDE8B P2RY14	1.30e-04	187	116	5	fa01a61bfd13feb033ba1e35cf513707b1bff8c8
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SIM1 NALF1 PKHD1 ADGRL2 NOS1	1.30e-04	187	116	5	77886f99c229610abd28c4c370d2c7d1536c9782
ToppCell	11.5-Airway-Mesenchymal-Pericyte\|Airway / Age, Tissue, Lineage and Cell class	PDE2A SLCO3A1 ADCY3 RBM20 P2RY14	1.33e-04	188	116	5	916971d8660fd20f616346953874e89d2cd13e88
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AURKA FNDC1 ASPM P2RY14 RAD21	1.33e-04	188	116	5	95d0a796d62ce6d121e2028c378faffc14b35275
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA3 SLCO3A1 NALF1 NCAN MAB21L1	1.33e-04	188	116	5	bd091503f580dedab40e0996273101285d24b586
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF208 SIM1 FRY NALF1 PKHD1	1.36e-04	189	116	5	8ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCell	Mesenchymal-pericyte_cell\|World / Lineage, Cell type, age group and donor	MYO10 PTEN ADCY3 PDE8B P2RY14	1.36e-04	189	116	5	d7ed96add29f219183c802895fbff519b627f635
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYO10 PTEN ADCY3 PDE8B P2RY14	1.40e-04	190	116	5	4eb92aef1ee868f4537483d19014d947b7684612
ToppCell	renal_medulla_nuclei-Adult_normal_reference\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	MYO10 SLCO3A1 SIM1 CCNY FRY	1.40e-04	190	116	5	f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF208 SIM1 FRY NALF1 PKHD1	1.40e-04	190	116	5	4836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYO10 PTEN ADCY3 PDE8B P2RY14	1.40e-04	190	116	5	7be4341e2909101d756f14031c21e705eb45e69a
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P5-P5_1-Sox4-POLYDENDROCYTE_(Rostral-�migratory_stream-�(RMS)_(Tuba1c))\|Striatum / BrainAtlas - Mouse McCarroll V32	NEB AURKA ASPM RAD21	1.41e-04	101	116	4	0b32e6071f05dbe808e51e18c3a3f8221f438f83
ToppCell	COVID-19-kidney-TAL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CYP24A1 SIM1 NALF1 PKHD1 NOS1	1.43e-04	191	116	5	fe55475ce0666ab5122447a813dc2369e24947b8
ToppCell	(1)_Control_(PBS)\|World / Stress and Cell class	STAB2 MYO10 HP PEAK1 PROS1	1.43e-04	191	116	5	b346e13259cb2d506b923ad44b894c21a3eee4c3
ToppCell	facs-Heart-RV-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A MYO10 SNRK FRY ADGRL2	1.43e-04	191	116	5	84ebb9f8e975acc88aa600c08a8aa791256948a6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF208 HMGCS2 SIM1 ADGRL2 VAV2	1.43e-04	191	116	5	96b78b4e819ea6052334bfcbc7abbf35897df885
ToppCell	COVID-19-kidney-Mito-rich_Distal\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CYP24A1 SIM1 DSCAML1 PKHD1 NOS1	1.43e-04	191	116	5	0965f621ebcd92ccdeb21cc27022180ce3cfe910
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY3 RBM20 JAK2 FRY NALF1	1.47e-04	192	116	5	bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY3 RBM20 JAK2 FRY NALF1	1.47e-04	192	116	5	b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCell	(4)_Endothelial_cells\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	PDE2A STAB2 SNRK JAK1 ALDOB	1.50e-04	193	116	5	ae6ba13d4d9f2a700887cdda2790c32007b29ac8
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AURKA FNDC1 ASPM P2RY14 RAD21	1.50e-04	193	116	5	a332dfdcc48c405020014e644aa4d14fda98cc86
ToppCell	facs-Liver-Non-hepatocytes-3m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A STAB2 SNRK JAK1 PEAK1	1.50e-04	193	116	5	8084fa0ce61f1f4a728423b6b81df04eaa5af5b6
ToppCell	COVID-19-kidney-FLT1+PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	PDE2A SNRK CCNY ELL2 ADGRL2	1.50e-04	193	116	5	479abb1cd2eb978b8a4fdb900069a6329fc8cade
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A STAB2 SNRK CCNYL1 PEAK1	1.54e-04	194	116	5	c8b9551b93a5aed62154b487db90130604a6125c
ToppCell	IPF-Stromal-Pericyte\|Stromal / Disease state, Lineage and Cell class	MYO10 PTEN ADCY3 PDE8B P2RY14	1.54e-04	194	116	5	3892b188f424ffb80f3c75a1b6709a21c1e1601d
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic-lymphocyte-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZNF569 MYO10 AURKA TBC1D32 ASPM	1.54e-04	194	116	5	8f4b63b0b9a40765205e4ca6bd94a675a83dbe3d
ToppCell	(4)_Endothelial_cells-(42)_EC-sinusoidal\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	PDE2A STAB2 SNRK JAK1 ALDOB	1.54e-04	194	116	5	4428b472c2042f88eae028b1770767512a515b75
ToppCell	COVID-19-lung-Pericytes/_Smooth_Muscle\|lung / Disease (COVID-19 only), tissue and cell type	ADCY3 RBM20 FRY PDE8B P2RY14	1.54e-04	194	116	5	5e1e0513a54ec4cf0b247ec85c9fbc68dfac1da3
ToppCell	(0)_Normal/No_Treatment-(1)_VE-Cad+_vascular_cells\|(0)_Normal/No_Treatment / Stress and Cell class	PDE2A STAB2 MYO10 SNRK JAK1	1.58e-04	195	116	5	e8ab3122f81cb22920becd6611cbd9f00db19d50
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	PDE2A STAB2 MYO10 SLCO3A1 ADGRL2	1.62e-04	196	116	5	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A STAB2 MYO10 SNRK PROS1	1.62e-04	196	116	5	81900dcc9451ff6606ec940c16b559d73247590e
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A STAB2 MYO10 SNRK PEAK1	1.66e-04	197	116	5	d584d0334ea97e3fa8c4cd869f5eeea2c7a1ed04
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG\|World / Primary Cells by Cluster	MYO10 REST RBM20 FNDC1 CELSR1	1.66e-04	197	116	5	61749ccafeb938c310cff1de5ff924a1c794325a
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A STAB2 MYO10 SNRK PEAK1	1.66e-04	197	116	5	412091994196a06c2779b4c2cfed84be889a5f8d
ToppCell	P03-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KCNB2 FNDC1 P2RY14 RIMS1 PROS1	1.66e-04	197	116	5	2cec938caf6ffd031cea37277071487e59b2c71c
Drug	Propranolol hydrochloride [318-98-9]; Down 200; 13.6uM; HL60; HT_HG-U133A	STAB2 NRF1 MYO10 FASTKD2 THRA PPIL2 EXOG PLD2 ENOX2	9.09e-07	199	117	9	3059_DN
Drug	Estriol [50-27-1]; Up 200; 13.8uM; PC3; HT_HG-U133A	TMEM53 CYP24A1 PHF7 THRA KCNF1 PLD2 ALDOB DNAH9	8.30e-06	197	117	8	5866_UP
Drug	Naringin hydrate [11032-30-7]; Down 200; 6.6uM; MCF7; HT_HG-U133A	SNRK REST NEB INO80D VPS13D PPIL2 UTY VAV2	8.30e-06	197	117	8	5666_DN
Drug	Atropine sulfate monohydrate [5908-99-6]; Up 200; 5.8uM; PC3; HT_HG-U133A	IFT140 PDE2A NRF1 SLCO3A1 NEB VPS13D ART1 PPIL2	8.62e-06	198	117	8	5865_UP
Drug	Cephapirin sodium salt [24356-60-3]; Up 200; 9uM; MCF7; HT_HG-U133A	NEB F5 JAK2 THRA RASSF1 NCAN PEAK1 ENOX2	8.94e-06	199	117	8	6790_UP
Drug	Androsterone [53-41-8]; Down 200; 13.8uM; PC3; HT_HG-U133A	IFT140 TMEM53 STAB2 ZNF208 THRA KCNF1 PDE8B PLD2	8.94e-06	199	117	8	4635_DN
Drug	11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene	FLT3 JAK2	2.62e-05	2	117	2	ctd:C561234
Drug	Etoposide [33419-42-0]; Down 200; 6.8uM; MCF7; HT_HG-U133A	IFT140 NRF1 NEB ADCY3 AURKA ASPM PPIL2	4.10e-05	180	117	7	5027_DN
Drug	dibutyryl cyclic GMP	PDE2A ADCY3 ART1 PLD2 NOS1 KLKB1	5.75e-05	130	117	6	CID000036095
Drug	Prochlorperazine dimaleate [84-02-6]; Down 200; 6.6uM; PC3; HT_HG-U133A	TMEM53 NRF1 PHF7 FASTKD2 NEB EXOG AFF4	6.17e-05	192	117	7	6664_DN
Drug	Mefloquine hydrochloride [51773-92-3]; Down 200; 9.6uM; MCF7; HT_HG-U133A	IFT140 STAB2 VPS13D KCNF1 PKP3 PPIL2 PLD2	7.02e-05	196	117	7	2210_DN
Drug	Trapidil [15421-84-8]; Down 200; 19.4uM; HL60; HT_HG-U133A	NRF1 NEB ADCY3 PDE8B PPIL2 NOS1 ENOX2	7.02e-05	196	117	7	3136_DN
Drug	Meptazinol hydrochloride [59263-76-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A	TMEM53 MYO10 TSC2 JAK2 VPS13D PPIL2 NOS1	7.25e-05	197	117	7	4774_DN
Drug	Dorzolamide hydrochloride [130693-82-2]; Down 200; 11uM; PC3; HT_HG-U133A	TMEM53 NRF1 REST INO80D VPS13D PPIL2 UTY	7.25e-05	197	117	7	5785_DN
Drug	Thiorphan [76721-89-6]; Up 200; 15.8uM; MCF7; HT_HG-U133A	NRF1 REST ART1 KCNF1 UTY AFF4 ENOX2	7.25e-05	197	117	7	6249_UP
Drug	Phenethicillin potassium salt [132-93-4]; Down 200; 10uM; MCF7; HT_HG-U133A	JAK2 VPS13D NALF1 PDE8B PPIL2 AFF4 ENOX2	7.25e-05	197	117	7	6105_DN
Drug	Pantothenic acid calcium salt monohydrate [63409-48-3]; Down 200; 8uM; PC3; HT_HG-U133A	ABCA3 STAB2 F5 KCNF1 PDE8B EXOG AFF4	7.25e-05	197	117	7	4189_DN
Drug	Vigabatrin [60643-86-9]; Up 200; 31uM; PC3; HT_HG-U133A	IFT140 VPS13D THRA ART1 PLD2 ALDOB UTY	7.25e-05	197	117	7	6314_UP
Drug	Colistin sulfate [1264-72-8]; Down 200; 3uM; MCF7; HT_HG-U133A	IFT140 TMEM53 VPS13D THRA PPIL2 PLD2 NOS1	7.25e-05	197	117	7	4796_DN
Drug	Theophylline monohydrate [5967-84-0]; Up 200; 20.2uM; HL60; HT_HG-U133A	HS2ST1 PPIL2 EXOG PLD2 ALDOB MAB21L1 ENOX2	7.49e-05	198	117	7	2986_UP
Drug	(R)-(+)-Atenolol [56715-13-0]; Down 200; 15uM; PC3; HT_HG-U133A	ABCA3 TMEM53 NRF1 FASTKD2 ADCY3 JAK2 VPS13D	7.49e-05	198	117	7	4259_DN
Drug	Chlormezanone [80-77-3]; Down 200; 14.6uM; PC3; HT_HG-U133A	IFT140 STAB2 SLCO3A1 ZNF208 VPS13D KCNF1 PDE8B	7.49e-05	198	117	7	4636_DN
Drug	Dimenhydrinate [523-87-5]; Up 200; 8.6uM; PC3; HT_HG-U133A	STAB2 NRF1 REST NEB SUCLG1 ART1 PPIL2	7.49e-05	198	117	7	6352_UP
Drug	Tolbutamide [64-77-7]; Up 200; 14.8uM; HL60; HT_HG-U133A	IFT140 NRF1 PHF7 F5 INO80D PKP3 PPIL2	7.73e-05	199	117	7	2359_UP
Drug	Iodipamide [606-17-7]; Down 200; 3.6uM; MCF7; HT_HG-U133A	TMEM53 MYO10 VPS13D NALF1 PKP3 PLD2 UTY	7.73e-05	199	117	7	6490_DN
Disease	Thromboembolism	F5 JAK2 PROS1	1.17e-05	12	113	3	C0040038
Disease	BUDD-CHIARI SYNDROME	F5 JAK2	1.45e-05	2	113	2	600880
Disease	Budd-Chiari Syndrome	F5 JAK2	1.45e-05	2	113	2	C0856761
Disease	Hepatic Vein Thrombosis	F5 JAK2	1.45e-05	2	113	2	C0019154
Disease	Budd-Chiari syndrome	F5 JAK2	1.45e-05	2	113	2	cv:C0856761
Disease	lung non-small cell carcinoma (is_implicated_in)	CYP24A1 PTEN JAK1 JAK2 RASSF1 RAD21	1.64e-05	139	113	6	DOID:3908 (is_implicated_in)
Disease	hepatocellular carcinoma (is_marker_for)	PHF6 TSC2 HMGCS2 PTEN JAK2 HP ASPM RAD21	2.16e-05	301	113	8	DOID:684 (is_marker_for)
Disease	Thrombus	FLT3 F5 KLKB1 PROS1	2.94e-05	46	113	4	C0087086
Disease	Thrombosis	FLT3 F5 KLKB1 PROS1	3.78e-05	49	113	4	C0040053
Disease	Septic Phlebitis, Sagittal Sinus	F5 PROS1	4.35e-05	3	113	2	C0751823
Disease	Sagittal Sinus Thrombophlebitis	F5 PROS1	4.35e-05	3	113	2	C0751824
Disease	Budd-Chiari syndrome (is_implicated_in)	F5 JAK2	4.35e-05	3	113	2	DOID:11512 (is_implicated_in)
Disease	Sagittal Sinus Thrombosis	F5 PROS1	4.35e-05	3	113	2	C0338575
Disease	portal hypertension (implicated_via_orthology)	PTEN JAK2 NOS1	5.07e-05	19	113	3	DOID:10762 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	PDE2A ABCA3 ZNF569 CYP24A1 UBR4 PHF7 SIM1 PTEN ZNF25 AURKA HP PLD2 DNAH9 HSP90AA1	6.33e-05	1074	113	14	C0006142
Disease	ovarian cancer (is_implicated_in)	PTEN JAK1 AURKA RASSF1	6.42e-05	56	113	4	DOID:2394 (is_implicated_in)
Disease	venous thromboembolism	LEKR1 GEMIN5 FASTKD2 F5 NALF1 ZNF718 CCR4 ADGRL2 KLKB1	7.18e-05	460	113	9	EFO_0004286
Disease	fetal alcohol spectrum disorder (biomarker_via_orthology)	GRIN2B PTEN	8.68e-05	4	113	2	DOID:0050696 (biomarker_via_orthology)
Disease	oral squamous cell carcinoma (is_marker_for)	FLT3 PTEN HP RAD21	1.02e-04	63	113	4	DOID:0050866 (is_marker_for)
Disease	angiomyolipoma (is_marker_for)	TSC2 PTEN	1.44e-04	5	113	2	DOID:3314 (is_marker_for)
Disease	factor VIII measurement, coagulation factor measurement	STAB2 VAV2	1.44e-04	5	113	2	EFO_0004630, EFO_0004634
Disease	obesity (biomarker_via_orthology)	NRF1 TF JAK2 HP NOS1	2.61e-04	147	113	5	DOID:9970 (biomarker_via_orthology)
Disease	disease of cellular proliferation (implicated_via_orthology)	JAK1 JAK2	3.01e-04	7	113	2	DOID:14566 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	ABCA3 TSC2 PTEN DSCAML1 RIMS1	3.05e-04	152	113	5	DOID:0060041 (implicated_via_orthology)
Disease	Colorectal Carcinoma	ABCA3 ZNF569 PTEN KCNB2 F5 DSCAML1 AURKA PKHD1 P2RY14 PROS1	3.75e-04	702	113	10	C0009402
Disease	Thrombophilia due to thrombin defect	F5 PROS1	4.01e-04	8	113	2	cv:C3160733
Disease	Polycythemia Vera	JAK1 JAK2	4.01e-04	8	113	2	C0032463
Disease	body height at birth	LEKR1 NHLRC2 ATAD2B	4.87e-04	40	113	3	EFO_0006784
Disease	Leukemia, Myelocytic, Acute	FLT3 TSC2 JAK1 JAK2 RAD21	5.51e-04	173	113	5	C0023467
Disease	hyperglycemia (is_implicated_in)	TF HP	6.41e-04	10	113	2	DOID:4195 (is_implicated_in)
Disease	Malignant neoplasm of kidney	TSC2 PTEN AURKA	6.90e-04	45	113	3	C0740457
Disease	Macrocephaly	PTEN THRA	7.82e-04	11	113	2	C0221355
Disease	glycerophosphorylcholine measurement	GRIN2B JAK1	7.82e-04	11	113	2	EFO_0020018
Disease	esophageal cancer (is_marker_for)	CYP24A1 PTEN	9.36e-04	12	113	2	DOID:5041 (is_marker_for)
Disease	neuropsychological test	GRIN2B KCNB2 TBC1D32 KCNF1 RIMS1	9.88e-04	197	113	5	EFO_0003926
Disease	prostate cancer (is_implicated_in)	FLT3 PTEN JAK1 RASSF1	1.08e-03	117	113	4	DOID:10283 (is_implicated_in)
Disease	cardiomyopathy (biomarker_via_orthology)	PDE2A NOS1	1.10e-03	13	113	2	DOID:0050700 (biomarker_via_orthology)
Disease	hematologic cancer (implicated_via_orthology)	JAK1 JAK2	1.10e-03	13	113	2	DOID:2531 (implicated_via_orthology)
Disease	ovary epithelial cancer (is_marker_for)	AURKA ASPM	1.10e-03	13	113	2	DOID:2152 (is_marker_for)
Disease	retinitis pigmentosa (biomarker_via_orthology)	GRIN2B PTEN	1.10e-03	13	113	2	DOID:10584 (biomarker_via_orthology)
Disease	Obesity	PHF6 SIM1 TF ADCY3 AFF4	1.18e-03	205	113	5	C0028754
Disease	leukemia	PTEN JAK2 HP	1.24e-03	55	113	3	C0023418
Disease	infant head circumference	LEKR1 NHLRC2	1.48e-03	15	113	2	EFO_0004577
Disease	thrombosis (is_implicated_in)	F5 JAK2	1.48e-03	15	113	2	DOID:0060903 (is_implicated_in)
Disease	colon cancer (is_marker_for)	CYP24A1 PTEN HSP90AA1	1.52e-03	59	113	3	DOID:219 (is_marker_for)
Disease	creatinine measurement	NRF1 CYP24A1 PHF7 SIM1 NEB FRY PKHD1 EXOG ADGRL2 ALDOB HSP90AA1	1.54e-03	995	113	11	EFO_0004518
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	FLT3 JAK1 JAK2	1.67e-03	61	113	3	C1961102
Disease	Schizoaffective disorder-bipolar type	STAB2 RAD21	1.68e-03	16	113	2	EFO_0009965
Disease	Diabetic Angiopathies	ADCY3 HP	1.68e-03	16	113	2	C0011875
Disease	Microangiopathy, Diabetic	ADCY3 HP	1.68e-03	16	113	2	C0025945
Disease	Blood Coagulation Disorders	F5 KLKB1	1.68e-03	16	113	2	C0005779
Disease	Multiple congenital anomalies	PTEN AFF4	1.90e-03	17	113	2	C0000772
Disease	ulcerative colitis (is_implicated_in)	CYP24A1 JAK2	1.90e-03	17	113	2	DOID:8577 (is_implicated_in)
Disease	Acute myeloid leukemia	FLT3 JAK2	1.90e-03	17	113	2	cv:C0023467
Disease	LEUKEMIA, ACUTE MYELOID	FLT3 JAK2	1.90e-03	17	113	2	601626
Disease	Fetal Alcohol Syndrome	REST NOS1	1.90e-03	17	113	2	C0015923
Disease	age at menarche	FLT3 MYO10 LEKR1 SIM1 KCNB2 DSCAML1 ADCY3 ADGRL2	2.07e-03	594	113	8	EFO_0004703
Disease	Malignant neoplasm of endometrium	PTEN RAD21	2.14e-03	18	113	2	C0007103
Disease	Carcinoma in situ of endometrium	PTEN RAD21	2.14e-03	18	113	2	C0346191
Disease	glomerulonephritis (is_marker_for)	TF KLKB1	2.38e-03	19	113	2	DOID:2921 (is_marker_for)
Disease	intrahepatic cholangiocarcinoma (is_marker_for)	PTEN HSP90AA1	2.38e-03	19	113	2	DOID:4928 (is_marker_for)
Disease	atherosclerosis (biomarker_via_orthology)	JAK2 HP	2.64e-03	20	113	2	DOID:1936 (biomarker_via_orthology)
Disease	Adenocarcinoma of prostate	PTEN AURKA	2.64e-03	20	113	2	C0007112
Disease	Deep Vein Thrombosis	F5 JAK2	2.91e-03	21	113	2	C0149871
Disease	Venous Thrombosis	F5 JAK2	2.91e-03	21	113	2	C0042487
Disease	stem Cell Growth Factor beta measurement	STAB2 F5 KLKB1	3.02e-03	75	113	3	EFO_0008292
Disease	portal hypertension (biomarker_via_orthology)	F5 HSP90AA1	3.19e-03	22	113	2	DOID:10762 (biomarker_via_orthology)
Disease	Autistic Disorder	TSC2 GRIN2B PTEN TF RIMS1	3.37e-03	261	113	5	C0004352
Disease	mean corpuscular hemoglobin concentration	IFT140 POLR1A LEKR1 TSC2 NEB PTEN TF AURKA ELL2 ATAD2B NCAN	3.46e-03	1105	113	11	EFO_0004528
Disease	Ovarian Serous Adenocarcinoma	SNRK JAK2	3.49e-03	23	113	2	C1335177
Disease	Carcinoma of lung	PTEN RAD21	3.49e-03	23	113	2	C0684249
Disease	Huntington's disease (is_implicated_in)	NRF1 GRIN2B	3.49e-03	23	113	2	DOID:12858 (is_implicated_in)
Disease	DNA methylation	SLCO3A1 GRIN2B SUCLG1 FRY ART1 PKHD1 RIMS1 ADGRL2	3.80e-03	656	113	8	GO_0006306
Disease	partial thromboplastin time	F5 KLKB1	3.80e-03	24	113	2	EFO_0004310
Disease	West Syndrome	TSC2 GRIN2B	3.80e-03	24	113	2	C0037769

Protein segments in the cluster

Peptide	Gene	Start	Entry
LEYSRLKNKHYFDCV	CATSPERG	896	Q6ZRH7
KYRCEYLHNKLAHIK	ELL2	611	O00472
YITELANALSYCHSK	AURKA	236	O14965
HSKHCRNKQKTFYYL	TBC1D32	406	Q96NH3
HCQYVTEKVLAAVYK	ALDOB	201	P05062
SYIKNHIKRYCSDNG	GVINP1	2156	Q7Z2Y8
SSEVAAHYCKKYNIQ	ABCA3	1276	Q99758
SYNKLQKREKTCRAY	ADGRL2	591	O95490
ERNHTYCKTKYSLNS	CCR4	181	P51679
KCVALAIYYHIKNRD	CCNY	121	Q8ND76
VLSAKVSCQRKHHYY	CELSR1	2631	Q9NYQ6
TVKCVTLAIYYHIKN	CCNYL1	141	Q8N7R7
NIRQYYVLCEHRKDK	DDX25	311	Q9UHL0
HRKDKYQALCNIYGS	DDX25	321	Q9UHL0
YRATICAKHKLYQFL	ASPM	2441	Q8IZT6
RNYSADHYLQEAKKL	AFF4	911	Q9UHB7
LSKEDYHCAKVINAY	RAD51AP2	441	Q09MP3
YHCAKVINAYEEQSK	RAD51AP2	446	Q09MP3
CRSAVHYRNLQKYLS	RBM20	1181	Q5T481
NFIRLCKKHYYDGTI	PPIL2	306	Q13356
KYSYCRQKIQEALHA	RASSF1	326	Q9NS23
IYHRKAKYLLADCNE	RAD21	66	O60216
NLYHENIVKYKGICT	JAK1	931	P23458
QHDNIVKYKGVCYSA	JAK2	906	O60674
YAASKKCNLQYHFKS	REST	396	Q13127
HSVRYQCKNYYKLRT	HP	46	P00738
SHLQDELKIKYRQSY	LEKR1	111	Q6ZMV7
KQLHLCYNIVKDRYV	NGLY1	491	Q96IV0
LLSQCIYRHRKDYDK	ATAD2B	1426	Q9ULI0
YICSYLHRLDNKICT	ENOX2	556	Q16206
LDRCYTSYRKKIQNQ	HMGCS2	266	P54868
LKYCQKNLLSHSYCL	OR51A7	166	Q8NH64
RVYSYALALKHANAK	NUDT5	196	Q9UKK9
SLLYKKVNEAQYRSH	PDE2A	551	O00408
CKSKAKESQQYYHSL	PEAK1	1361	Q9H792
KCNIFKNIDRNHYRT	PDE8B	701	O95263
VKNCYKQHGREDLLY	NRF1	266	Q16656
RKHCYRLYTKLLNEA	MYO10	1471	Q9HD67
VKEKYYRHFLQITLC	EBPL	121	Q9BY08
CLKSKYQSYRHQAEF	LILRB5	366	O75023
CYTNHALSYDQAKRV	EXOG	76	Q9Y2C4
QRTENIDIKKYCVHY	GGPS1	236	O95749
RSLRYCKKNQLSHSY	OR51A2	166	Q8NGJ7
RNLRYCKKNQLSHSY	OR51A4	166	Q8NGJ6
RNLLYVADSYNHKIK	NHLRC2	486	Q8NBF2
TRKYNTKAAYCQSKL	RDH13	191	Q8NBN7
KDSAYRQCLYLQLEH	PKD1L2	1746	Q7Z442
YICNHVKYATNKGNL	NOS1	446	P29475
KYNIHKDQYRSCDNV	RIMS1	1321	Q86UR5
LLYATYKKCTFALQH	FANCD2OS	161	Q96PS1
ILRCTKYNQELYTTH	CCDC105	361	Q8IYK2
LICHKYKKQFRYESQ	FLT3	561	P36888
IYLESCCQARYHQKK	KCNB2	131	Q92953
YHQNRLSKKELYAAV	CYP24A1	306	Q07973
LKERYYHICAKLANV	DMAP1	191	Q9NPF5
YRCITKHKYSGETRQ	DSCAML1	196	Q8TD84
CNSLRYKIYLSDNLK	FNDC1	1801	Q4ZHG4
AKYHQLRIKILGDCY	ADCY3	356	O60266
TFTILSYRHQDKYCQ	MS4A14	126	Q96JA4
VTQLCTYFQQKYKHL	INO80D	371	Q53TQ3
TYFQQKYKHLCRLER	INO80D	376	Q53TQ3
TFHKAEYRNNCLLKY	KLKB1	156	P03952
NYENCGKAYTKRSHL	KLF17	286	Q5JT82
LYQLCKELLSKQDHY	DNAH9	2026	Q9NYC9
DRNHQITRYQYCALK	FRY	1146	Q5TBA9
CTRMKENQKHIYYIT	HSP90AA1	481	P07900
KLYEALQKHVYCFRI	CGRRF1	106	Q99675
LQNHYRKYLCLLASD	POLRMT	526	O00411
YRKCKRHDLLNKFYQ	IFT140	866	Q96RY7
KIYNLCAERHYDTAK	PTEN	66	P60484
DTIQRSKNHYQKRAY	USP9X	2371	Q93008
SKNHYQKRAYQCIKC	USP9X	2376	Q93008
RKYHSAKEAYEQLLQ	UTY	216	O14607
EEKVLRLHYANCKAY	POLR1A	571	O95602
HTQHYECYRYQKLQK	SEPTIN14	301	Q6ZU15
QCLRKNYKRYIKNHE	SLCO3A1	646	Q9UIG8
IQTQGAKHYLKSCYT	F5	1976	P12259
HLNKYYNEKCQARKA	MAB21L1	11	Q13394
SQAIYHRKCIQKYAH	PHF7	181	Q9BWX1
HTYSSLNHVYKCQNK	FASTKD2	461	Q9NYY8
KAKYNVHATVRYQCN	NCAN	1231	O14594
NIAYDLCAKNKYHVL	HS2ST1	91	Q7LGA3
KVIHCSGYLKIRQYS	SIM1	181	P81133
ERSYHIFYQILSNKK	MYH3	281	P11055
AQKGYRLDQYTHLCL	PKHD1	601	P08F94
KKESCITYHLLYFNC	ABCC12	1006	Q96J65
QNKHCLVTVEKGSYY	PROS1	471	P07225
TEAHYSCQSKEILRY	P2RY14	261	Q15391
AKKYFAQIVHAISYC	SNRK	116	Q9NRH2
CSYTASRQHLYVDKN	SUCLG1	41	P53597
AYIQHKCYSDAAAKK	PKP3	341	Q9Y446
VCYKKFVTQQQYRDH	ZNF451	216	Q9Y4E5
NMSRGIYKLYCKNHS	PHF6	316	Q8IWS0
IYKLYCKNHSGNDER	PHF6	321	Q8IWS0
NLHKRIHSAQKYYKC	ZNF718	271	Q3SXZ3
LCYNHVVESEKLLKY	TTC39B	606	Q5VTQ0
CLAKLHDRNTYEKYL	TF	656	P02787
LAKYSAIYHKRGCIV	TMEM53	51	Q6P2H8
QKYGNTKTYRRHCQT	GEMIN5	1491	Q8TEQ6
NQLSYAQKAKYHLCS	STAB2	2231	Q8WWQ8
YNFADHCYNRIKLKK	PREPL	31	Q4J6C6
GQCYEFLSQHTLKKY	USP9Y	261	O00507
RSKNHYQKRAYQCIK	USP9Y	2376	O00507
RQSLCHYTLKDNKVY	POGLUT2	186	Q6UW63
TQYGRTHIREKSYKC	ZNF677	251	Q86XU0
KVFSYYSCLARHRKI	ZNF841	516	Q6ZN19
KCFYQKSALTVHQRT	ZNF25	321	P17030
HKRIYTRENSYKCEE	ZNF208	191	O43345
KHYKIHSREQSYKCN	ZNF569	231	Q5MCW4
DLHDCYLKYINLKAS	SF3A3	141	Q12874
IQKNLHPTYSCKYDS	THRA	81	P10827
YYQCHSLKESFKQLD	VAV2	746	P52735
TVKCDQCRHVVSKYY	WNT8A	321	Q9H1J5
ARYYINHNERKVTCK	PLEKHA5	71	Q9HAU0
CAKCFRYKQSLKYHL	ZNF777	811	Q9ULD5
VYQCHKCRSINYDEK	UBR4	3681	Q5T4S7
TRHAASKQKYLENYL	PLD2	156	O14939
TALISYHNYLDKTKQ	TSC2	771	P49815
NLSSVHCSLDLYKYK	VPS13D	2231	Q5THJ4
RYYNKQRVLETAAKH	KCNF1	411	Q9H3M0
LHKYLQSEEYSVKSC	NALF1	286	B1AL88
LRALGKHSTYNCEYI	ART1	266	P52961
CYNTHEKRIYQSNML	GRIN2B	321	Q13224
HARKAYDLQSDNLYK	NEB	3371	P20929