Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

PIKFYVE CDC42BPG PPM1D PRKAA1 MAP3K14 CAMK1G PRKDC EIF2AK3 MAP3K1

7.91e-06446619GO:0004674
GeneOntologyMolecularFunctionprotein kinase activity

PIKFYVE CDC42BPG PPM1D PRKAA1 MAP3K14 CAMK1G PRKDC EIF2AK3 MUSK MAP3K1

1.26e-056006110GO:0004672
GeneOntologyMolecularFunctionprotein serine kinase activity

PIKFYVE CDC42BPG PRKAA1 MAP3K14 CAMK1G PRKDC EIF2AK3 MAP3K1

1.40e-05363618GO:0106310
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

PIKFYVE CDC42BPG PPM1D PRKAA1 MAP3K14 CAMK1G PRKDC EIF2AK3 MUSK MAP3K1

5.24e-057096110GO:0016773
GeneOntologyMolecularFunctionkinase activity

PIKFYVE CDC42BPG PPM1D PRKAA1 MAP3K14 CAMK1G PRKDC EIF2AK3 MUSK MAP3K1

9.76e-057646110GO:0016301
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

PIKFYVE CDC42BPG PPM1D PRKAA1 MAP3K14 THG1L CAMK1G PRKDC EIF2AK3 MUSK MAP3K1

1.12e-049386111GO:0016772
GeneOntologyMolecularFunctionstructural constituent of postsynaptic actin cytoskeleton

POTEI POTEJ

4.96e-0411612GO:0098973
MousePhenoincreased granulocyte number

SELE TET2 RAB19 YOD1 DLGAP2 FCGR2A MAP3K14 PRKDC SIRT7 CHORDC1

1.00e-055974310MP:0000322
MousePhenoabnormal myeloid leukocyte morphology

SELE TET2 RAB19 YOD1 DLGAP2 NLRP12 THRB FCGR2A MAP3K14 LAMA3 DIP2C PRKDC SIRT7 CHORDC1

1.86e-0512924314MP:0008250
MousePhenoabnormal granulocyte number

SELE TET2 RAB19 YOD1 DLGAP2 NLRP12 FCGR2A MAP3K14 PRKDC SIRT7 CHORDC1

2.27e-058054311MP:0020201
MousePhenoabnormal granulocyte morphology

SELE TET2 RAB19 YOD1 DLGAP2 NLRP12 FCGR2A MAP3K14 PRKDC SIRT7 CHORDC1

3.18e-058354311MP:0002441
MousePhenoabnormal phagocyte morphology

SELE TET2 YOD1 DLGAP2 NLRP12 THRB FCGR2A LAMA3 DIP2C PRKDC SIRT7 CHORDC1

4.45e-0510334312MP:0008251
MousePhenothymus cyst

MAP3K14 PRKDC

5.52e-054432MP:0014130
MousePhenodecreased NK T cell number

MAP3K14 NCF2 PRKDC NUDCD3

7.64e-0574434MP:0008040
MousePhenoabnormal immunoglobulin light chain V-J recombination

PRKDC NUDCD3

9.19e-055432MP:0008761
MousePhenoliver inflammation

TET2 FCGR2A MAP3K14 PRKDC SIRT7

1.11e-04156435MP:0001860
MousePhenoincreased neutrophil cell number

SELE TET2 YOD1 DLGAP2 FCGR2A PRKDC CHORDC1

1.18e-04368437MP:0000219
MousePhenoabnormal neutrophil cell number

SELE TET2 YOD1 DLGAP2 NLRP12 FCGR2A PRKDC CHORDC1

1.20e-04499438MP:0012440
MousePhenoabsent thymus corticomedullary boundary

MAP3K14 PRKDC

1.38e-046432MP:0013741
MousePhenoabnormal neutrophil morphology

SELE TET2 YOD1 DLGAP2 NLRP12 FCGR2A PRKDC CHORDC1

1.41e-04511438MP:0005065
MousePhenomyeloid hyperplasia

TET2 PPM1D PRKDC

1.52e-0434433MP:0010373
MousePhenosmall thymus

PIKFYVE PPM1D MAP3K14 DIP2C PRKDC NUDCD3

2.24e-04286436MP:0000706
MousePhenolung inflammation

FCGR2A MAP3K14 LAMA3 NCF2 PRKDC

2.46e-04185435MP:0001861
MousePhenoincreased chronic myelocytic leukemia incidence

TET2 CHORDC1

2.56e-048432MP:0005481
MousePhenoincreased inflammatory response

SELE TET2 YOD1 NLRP12 FCGR2A MAP3K14 LAMA3 NCF2 PRKDC SIRT7 MAP3K1

3.12e-0410774311MP:0001846
MousePhenoabnormal NK T cell morphology

MAP3K14 NCF2 PRKDC NUDCD3

3.18e-04107434MP:0008036
MousePhenoabnormal NK T cell number

MAP3K14 NCF2 PRKDC NUDCD3

3.18e-04107434MP:0008038
MousePhenoabnormal red blood cell distribution width

PRKAA1 CHD1 NUDCD3 CHORDC1 PTGIS MAP3K1

4.03e-04319436MP:0010066
MousePhenoabnormal inflammatory response

SELE TET2 YOD1 NLRP12 FCGR2A PPM1D MAP3K14 LAMA3 NCF2 PRKDC SIRT7 MAP3K1

4.27e-0413104312MP:0001845
MousePhenoabnormal myelopoiesis

TET2 PPM1D PRKDC CHORDC1

4.77e-04119434MP:0001601
MousePhenoabnormal circulating thyroxine level

ZMYND11 THRB NCF2

5.09e-0451433MP:0005475
MousePhenoabnormal endocrine gland morphology

PIKFYVE TET2 ZMYND11 THRB PPM1D MAP3K14 DIP2C PRKDC NUDCD3 EIF2AK3 PTGIS

5.24e-0411444311MP:0013560
MousePhenodecreased leukocyte cell number

SELE TET2 RAB19 YOD1 DLGAP2 NLRP12 PPM1D MAP3K14 NCF2 PRKDC NUDCD3 CHORDC1

5.33e-0413424312MP:0000221
MousePhenorespiratory system inflammation

FCGR2A MAP3K14 LAMA3 NCF2 PRKDC

5.46e-04220435MP:0002405
MousePhenoabnormal germinal center B cell number

FCGR2A MAP3K14 NCF2

6.36e-0455433MP:0013680
MousePhenoabnormal germinal center B cell morphology

FCGR2A MAP3K14 NCF2

6.36e-0455433MP:0008176
MousePhenodecreased lymphocyte cell number

TET2 RAB19 YOD1 DLGAP2 PPM1D MAP3K14 NCF2 PRKDC NUDCD3 CHORDC1

6.87e-049924310MP:0005016
MousePhenoabnormal T cell receptor V(D)J recombination

PRKDC NUDCD3

7.06e-0413432MP:0008754
MousePhenoabnormal immunoglobulin V(D)J recombination

PRKDC NUDCD3

7.06e-0413432MP:0008755
MousePhenoincreased circulating thyroxine level

ZMYND11 THRB

9.46e-0415432MP:0005477
DomainANK

POTEB3 POTED POTEI POTEJ POTEB2 POTEB

1.38e-04251596SM00248
DomainANK_REPEAT

POTEB3 POTED POTEI POTEJ POTEB2 POTEB

1.44e-04253596PS50088
DomainANK_REP_REGION

POTEB3 POTED POTEI POTEJ POTEB2 POTEB

1.47e-04254596PS50297
DomainAnkyrin_rpt

POTEB3 POTED POTEI POTEJ POTEB2 POTEB

1.74e-04262596IPR002110
DomainProtein_kinase_ATP_BS

CDC42BPG PRKAA1 MAP3K14 CAMK1G EIF2AK3 MUSK MAP3K1

1.84e-04379597IPR017441
DomainKinase-like_dom

CDC42BPG PRKAA1 MAP3K14 CAMK1G PRKDC EIF2AK3 MUSK MAP3K1

2.88e-04542598IPR011009
DomainPROTEIN_KINASE_ATP

CDC42BPG PRKAA1 MAP3K14 CAMK1G EIF2AK3 MUSK MAP3K1

5.85e-04459597PS00107
DomainProt_kinase_dom

CDC42BPG PRKAA1 MAP3K14 CAMK1G EIF2AK3 MUSK MAP3K1

8.50e-04489597IPR000719
DomainCS

NUDCD3 CHORDC1

8.71e-0414592PF04969
DomainPROTEIN_KINASE_DOM

CDC42BPG PRKAA1 MAP3K14 CAMK1G EIF2AK3 MUSK MAP3K1

8.91e-04493597PS50011
DomainSer/Thr_kinase_AS

CDC42BPG PRKAA1 MAP3K14 CAMK1G EIF2AK3 MAP3K1

8.98e-04357596IPR008271
DomainS_TKc

CDC42BPG PRKAA1 MAP3K14 CAMK1G EIF2AK3 MAP3K1

9.24e-04359596SM00220
DomainPROTEIN_KINASE_ST

CDC42BPG PRKAA1 MAP3K14 CAMK1G EIF2AK3 MAP3K1

9.65e-04362596PS00108
DomainCS_dom

NUDCD3 CHORDC1

1.14e-0316592IPR007052
DomainActin_CS

POTEI POTEJ

1.14e-0316592IPR004001
DomainCS

NUDCD3 CHORDC1

1.14e-0316592PS51203
DomainAnkyrin_rpt-contain_dom

POTEB3 POTEI POTEJ POTEB2 POTEB

1.23e-03254595IPR020683
DomainPkinase

CDC42BPG PRKAA1 MAP3K14 CAMK1G EIF2AK3 MAP3K1

1.25e-03381596PF00069
DomainACTINS_2

POTEI POTEJ

1.29e-0317592PS00432
DomainActin/actin-like_CS

POTEI POTEJ

1.45e-0318592IPR020902
DomainACTINS_ACT_LIKE

POTEI POTEJ

1.62e-0319592PS01132
DomainPentatricopeptide_repeat

PRKDC KLC1

2.38e-0323592IPR002885
Domain-

NUDCD3 CHORDC1

2.38e-03235922.60.40.790
DomainHSP20-like_chaperone

NUDCD3 CHORDC1

3.04e-0326592IPR008978
DomainActin

POTEI POTEJ

4.30e-0331592IPR004000
DomainActin

POTEI POTEJ

4.30e-0331592PF00022
DomainACTIN

POTEI POTEJ

4.30e-0331592SM00268
DomainHelicase_C

CHD1 DDX60L DDX1

4.71e-03107593PF00271
DomainHELICc

CHD1 DDX60L DDX1

4.71e-03107593SM00490
DomainAnk_2

POTEB3 POTEI POTEJ POTEB2

4.74e-03215594PF12796
DomainHelicase_C

CHD1 DDX60L DDX1

4.83e-03108593IPR001650
DomainHELICASE_CTER

CHD1 DDX60L DDX1

4.96e-03109593PS51194
DomainHELICASE_ATP_BIND_1

CHD1 DDX60L DDX1

4.96e-03109593PS51192
DomainDEXDc

CHD1 DDX60L DDX1

4.96e-03109593SM00487
DomainP-loop_NTPase

RAB19 NLRP12 DNAH12 SULT2A1 MYO1B CHD1 DDX60L DDX1

4.98e-03848598IPR027417
DomainHelicase_ATP-bd

CHD1 DDX60L DDX1

5.09e-03110593IPR014001
DomainAnk

POTED POTEI POTEJ POTEB

5.83e-03228594PF00023
Domain-

POTEB3 POTEI POTEJ POTEB2

7.80e-032485941.25.40.20
Domain-

RAB19 NLRP12 DNAH12 SULT2A1 CHD1 DDX60L DDX1

8.86e-037465973.40.50.300
Pubmed

POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.

POTEB3 POTED POTEJ POTEB2 POTEB

8.51e-13862512475935
Pubmed

Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.

POTEB3 POTED POTEB

1.88e-07762315276201
Pubmed

Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.

POTED POTEI POTEJ

4.50e-07962316364570
Pubmed

USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma.

HNRNPM MYO1B PRKDC

8.81e-071162335449157
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

PIKFYVE PPM1D MYO1B NUDCD3 POTEI POTEJ ZMYM4 DDX1 KNL1

9.71e-0758862938580884
Pubmed

Genetic influences on the end-stage effector phase of arthritis.

SELE FCGR2A NCF2

2.97e-061662311489951
Pubmed

An accessory role of TCRgammadelta (+) cells in the exacerbation of inflammatory bowel disease in TCRalpha mutant mice.

MAP3K14 PRKDC

3.13e-06262211298322
Pubmed

Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.

THRB NCOA4

3.13e-06262228864529
Pubmed

Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells.

FCGR2A PRKDC

3.13e-06262215664957
Pubmed

NLRP12 Promotes Mouse Neutrophil Differentiation through Regulation of Non-canonical NF-κB and MAPKERK1/2 Signaling.

NLRP12 MAP3K14

3.13e-06262229483833
Pubmed

Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation.

PRKAA1 KLC1

3.13e-06262221099273
Pubmed

Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.

MAP3K14 PRKDC

3.13e-06262218292290
Pubmed

E-selectin rs5361 and FCGR2A rs1801274 variants were associated with increased risk of gastric cancer in a Chinese population.

SELE FCGR2A

3.13e-06262221780194
Pubmed

E- and p-selectins are essential for repopulation of chronic myelogenous and chronic eosinophilic leukemias in a scid mouse xenograft model.

SELE PRKDC

9.37e-06362223922938
Pubmed

The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.

MAP3K14 MAP3K1

9.37e-06362212049732
Pubmed

Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes.

NLRP12 MAP3K14

9.37e-06362217237370
Pubmed

Intestinal gamma delta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles.

MAP3K14 PRKDC

9.37e-06362215699117
Pubmed

Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner.

PIKFYVE PRKAA1

9.37e-06362234107300
Pubmed

The Vertebrate Genome Annotation browser 10 years on.

POTEB3 POTEI POTEJ POTEB2 POTEB

1.11e-0516362524316575
Pubmed

Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.

MAP3K14 MAP3K1

1.87e-0546229819420
Pubmed

FcγRIIb and BAFF differentially regulate peritoneal B1 cell survival.

FCGR2A PRKDC

1.87e-05462222516957
Pubmed

Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway.

PPM1D PRKDC

1.87e-05462220668064
Pubmed

Endosomal phosphoinositides and human diseases.

PIKFYVE SBF2

1.87e-05462218429927
Pubmed

FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells.

FCGR2A PRKDC

1.87e-05462236759517
Pubmed

Homeostatic regulation of intestinal villous epithelia by B lymphocytes.

MAP3K14 PRKDC

1.87e-05462211884426
Pubmed

Autoimmune thyroiditis in Fcgamma receptor-deficient nonobese diabetic mice.

FCGR2A PRKDC

3.12e-05562219447681
Pubmed

The Ku70 autoantigen interacts with p40phox in B lymphocytes.

NCF2 PRKDC

3.12e-0556229914162
Pubmed

CGK733-induced LC3 II formation is positively associated with the expression of cyclin-dependent kinase inhibitor p21Waf1/Cip1 through modulation of the AMPK and PERK/CHOP signaling pathways.

PRKAA1 EIF2AK3

3.12e-05562226486079
Pubmed

Mutant IDH Inhibits IFNγ-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma.

TET2 PRKDC

3.12e-05562234848557
Pubmed

Personalized copy number and segmental duplication maps using next-generation sequencing.

POTEB3 POTEB

3.12e-05562219718026
Pubmed

C-reactive protein promotes bone destruction in human myeloma through the CD32-p38 MAPK-Twist axis.

FCGR2A PRKDC

3.12e-05562229233917
Pubmed

HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium.

SELE LAMA3

4.67e-0566229597096
Pubmed

Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.

POTEB2 POTEB

4.67e-05662217171436
Pubmed

PtdIns5P regulation through evolution: roles in membrane trafficking?

PIKFYVE SBF2

4.67e-05662218774718
Pubmed

Quantitative nanoproteomics for protein complexes (QNanoPX) related to estrogen transcriptional action.

HNRNPM MYO1B PRKDC

5.48e-054162319805454
Pubmed

Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.

NLRP12 FCGR2A PRKAA1 MAP3K14 ULBP1

5.88e-0523162521048031
Pubmed

DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.

PRKAA1 PRKDC

6.53e-05762231983282
Pubmed

Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse.

FCGR2A PRKDC

6.53e-05762233117338
Pubmed

Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.

MAP3K14 MAP3K1

6.53e-05762216286467
Pubmed

Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients.

MAP3K14 MAP3K1

6.53e-05762219262425
Pubmed

Genetic control of NKT cell numbers maps to major diabetes and lupus loci.

SELE FCGR2A

8.69e-05862212960309
Pubmed

MEKK1 binds raf-1 and the ERK2 cascade components.

NCOA4 MAP3K1

8.69e-05862210969079
Pubmed

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.

MAP3K14 MAP3K1

8.69e-0586229689078
Pubmed

TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis.

MAP3K14 MAP3K1

8.69e-05862215001576
Pubmed

Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator.

THRB PRKDC

8.69e-05862210823961
Pubmed

FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.

SBF2 PRKAA1 HNRNPM MYO1B CHD1 PRKDC DDX1

9.60e-0560162733658012
Pubmed

Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice.

SELE NCF2

1.39e-041062211197687
Pubmed

Ppm1E is an in cellulo AMP-activated protein kinase phosphatase.

PPM1D PRKAA1

1.39e-041062220801214
Pubmed

CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.

HNRNPM MYO1B PRKDC POTEI POTEJ

1.65e-0428862531501420
Pubmed

DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.

HNRNPM MYO1B PRKDC

1.98e-046362337052853
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

PRKAA1 MYO1B CHD1 DDX60L SNX33 MAP3K1 KLC1 KNL1

2.07e-0491062836736316
Pubmed

Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).

DNAH12 LAMA3 MYO1B

2.18e-046562332120844
Pubmed

The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules.

HNRNPM PRKDC DDX1

2.18e-046562332521226
Pubmed

TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF.

NCF2 MYBPC1

2.41e-041362216052631
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

LENG8 HNRNPM MYO1B CHD1 PRKDC NUDCD3 KLC1 KNL1

2.46e-0493462833916271
Pubmed

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

PPM1D SBF2 HNRNPM THG1L

2.46e-0417062423314748
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PIKFYVE SBF2 DIP2C ZNF407 TOGARAM1 ARHGAP28

2.47e-0449362615368895
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

LENG8 HNRNPM MYO1B POTEI POTEJ DDX1

2.84e-0450662630890647
Pubmed

MAP3Ks as central regulators of cell fate during development.

MAP3K14 MAP3K1

3.23e-041562218855897
Pubmed

Identification of a novel actin isoform in hepatocellular carcinoma.

POTEI POTEJ

3.23e-041562216824795
Pubmed

Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity.

THRB PRKDC

3.23e-041562217242407
Pubmed

Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis.

MAP3K14 MAP3K1

3.69e-041662218434448
Pubmed

Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing.

HNRNPM DDX1

3.69e-041662216230076
Pubmed

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.

PIKFYVE TET2 CDC42BPG HNRNPM MYO1B

4.22e-0435362527545878
Pubmed

Genome-scale RNAi screen for host factors required for HIV replication.

POTEB3 SBF2 PRKAA1 MAP3K14 DDX60L

4.67e-0436162518976975
Pubmed

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

MAP3K14 HNRNPM NUDCD3 CHORDC1 MUSK

4.79e-0436362525036637
Pubmed

Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis.

MAP3K1 MYBPC1

5.24e-041962223201579
Pubmed

Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation.

CAMK1G KLC1

5.24e-041962215529118
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

HNRNPM PRKDC ZMYM4 DDX1

6.52e-0422062435785414
Pubmed

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.

HNRNPM MYO1B PRKDC DDX1

6.63e-0422162429991511
Pubmed

p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells.

PRKDC POTEJ

7.06e-042262225331947
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

PRKAA1 HNRNPM SNX33 PRKDC CHORDC1 DDX1 MAP3K1

7.46e-0484462725963833
Pubmed

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

PRKAA1 HNRNPM MYO1B PRKDC KNL1

7.50e-0440162525852190
Pubmed

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.

MAP3K14 PRKDC

7.72e-042362222761313
Pubmed

IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.

NLRP12 PRKDC

7.72e-042362234473953
Pubmed

CHFR regulates chemoresistance in triple-negative breast cancer through destabilizing ZEB1.

HNRNPM PRKDC DDX1

7.94e-0410162334462429
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

HNRNPM CHD1 PRKDC ZMYM4 DDX1

8.37e-0441162535182466
Pubmed

USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID.

HNRNPM PRKDC

8.41e-042462234983926
Pubmed

Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.

THRB HNRNPM MYO1B PRKDC NCOA4 DDX1

8.68e-0462662633644029
Pubmed

Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.

HNRNPM MYO1B PRKDC DDX1

9.58e-0424462428902428
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

DLGAP2 ZMYND11 HNRNPM MAP3K1 KLC1

1.02e-0343062535044719
Pubmed

Shwachman-Bodian Diamond syndrome is a multi-functional protein implicated in cellular stress responses.

HNRNPM PRKDC

1.07e-032762219602484
Pubmed

Drp1 regulates transcription of ribosomal protein genes in embryonic hearts.

PRKAA1 SIRT7

1.07e-032762235099001
Pubmed

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.

TET2 HNRNPM

1.07e-032762223395962
Pubmed

Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.

HNRNPM PRKDC

1.15e-032862219596686
Pubmed

A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.

MYO1B CHD1 PRKDC

1.24e-0311862327377895
Pubmed

The TIP60 Complex Is a Conserved Coactivator of HIF1A.

HNRNPM MYO1B PRKDC

1.31e-0312062327320910
Pubmed

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

TET2 DDX1

1.32e-033062221946350
Pubmed

Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.

HNRNPM PRKDC

1.32e-033062221575865
Pubmed

Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy.

HNRNPM PRKDC

1.32e-033062235152003
Pubmed

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

HNRNPM MYO1B PRKDC DDX1

1.35e-0326862433024031
Pubmed

Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10.

SELE FCGR2A

1.41e-033162215921521
Pubmed

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.

HNRNPM POTEI POTEJ DDX1

1.41e-0327162432433965
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

TET2 HNRNPM MYO1B PRKDC

1.43e-0327262431010829
Pubmed

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.

PRKAA1 CHD1 CAMK1G PRKDC

1.51e-0327662428319085
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

LENG8 HNRNPM CHD1 PRKDC ZMYM4 DDX1 KNL1

1.51e-0395462736373674
Pubmed

Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.

PPM1D PRKDC

1.69e-033462211101529
Pubmed

Expression of the Bcl-2 protein BAD promotes prostate cancer growth.

MAP3K14 MAP3K1

1.69e-033462219593445
Pubmed

HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.

ZNF594 KLC1

1.69e-033462225925205
Pubmed

A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.

HNRNPM MYO1B PRKDC DDX1

1.72e-0328662432041737
Cytoband1q32.2

YOD1 CAMK1G

6.16e-04276221q32.2
Cytoband2q21.1

POTEI POTEJ

2.83e-03586222q21.1
CytobandEnsembl 112 genes in cytogenetic band chr15q11

POTEB3 POTEB2 POTEB

3.21e-03217623chr15q11
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTED POTEI POTEJ POTEB2 POTEB

6.71e-1113425685
GeneFamilyAnkyrin repeat domain containing

POTED POTEI POTEJ POTEB2 POTEB

2.34e-04242425403
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

MAP3K14 MAP3K1

1.41e-0324422654
CoexpressionGSE14308_TH1_VS_NAIVE_CD4_TCELL_DN

TET2 MAP3K14 SIRT7 CHORDC1 ZMYM4 MAP3K1

7.17e-06200616M3377
CoexpressionAIZARANI_LIVER_C23_KUPFFER_CELLS_3

TET2 PLBD1 NLRP12 FCGR2A NCF2 DDX60L

1.27e-05221616M39124
CoexpressionTRAVAGLINI_LUNG_CLASSICAL_MONOCYTE_CELL

TET2 PLBD1 FCGR2A NCF2 NCOA4 MAP3K1

3.90e-05270616M41699
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FCGR2A NCF2 CHD1 DDX60L PRKDC CLEC2B

3.27e-071976263cd1c816bc7a57278b2ef615b69545356ab8f522
ToppCellcontrol-Neutrophil|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TET2 PLBD1 NLRP12 FCGR2A NCF2 NCOA4

3.58e-07200626b5d197472799cc61d7497faed91ac2564ae4930a
ToppCell356C-Myeloid-Monocyte-CD16+_Monocyte|356C / Donor, Lineage, Cell class and subclass (all cells)

TET2 CDC42BPG DLGAP2 NLRP12 SULT2A1

3.41e-0616562535a6de30438de364ccca948fc932da541a69ef89
ToppCellControl-Myeloid-Monocytes|Control / group, cell type (main and fine annotations)

NLRP12 FCGR2A SBF2 NCF2 MAP3K1

6.61e-061896253335d16bd0ffa0c1ddd06d7da645299148130c3f
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FCGR2A NCF2 CHD1 PRKDC CLEC2B

6.96e-0619162547156e5f1d790707f42f6283104a44b33af613e5
ToppCellChildren_(3_yrs)-Immune-monocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

TET2 DLGAP2 NLRP12 FCGR2A MAP3K1

7.32e-0619362558e1930a1d80ad3729ab9604ac8ebf7308232a3d
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FCGR2A NCF2 DDX60L PRKDC CLEC2B

7.89e-06196625fe8d3f45a64323947c36b127355d5940eb56c0ca
ToppCellCOVID-19-Myeloid-Monocytes|COVID-19 / group, cell type (main and fine annotations)

TET2 FCGR2A SBF2 NCF2 MAP3K1

7.89e-0619662504d710267658ea5601ae2cfb4ed5acb8a29bd8a1
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TET2 FCGR2A CHD1 CHORDC1 EIF2AK3

7.89e-0619662501cea0bb0b938d0986fd2ddae06597b8af1768ee
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FCGR2A NCF2 DDX60L PRKDC CLEC2B

7.89e-06196625526d037bb12d81f1c235c60ddc787fbad0bbad77
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|lung / Disease (COVID-19 only), tissue and cell type

NLRP12 FCGR2A NCF2 DDX60L MAP3K1

8.08e-06197625a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FCGR2A NCF2 CHD1 DDX60L CLEC2B

8.08e-06197625340ce4fef244176fb52e38ffbcbdfda5ac3467dd
ToppCellCOVID-19_Severe-Neu_1|COVID-19_Severe / 5 Neutrophil clusters in COVID-19 patients

TET2 FCGR2A NCF2 DDX60L CLEC2B

8.28e-06198625bbe639ea5a636c985e509fb0a133ae3b60afac5a
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TET2 FCGR2A NCF2 CHD1 DDX60L

8.49e-061996255b6feacb0ca92c3fc6b327be978320426dcf6f68
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLBD1 FCGR2A NCF2 DDX60L CHORDC1

8.49e-06199625fde8e3ba19d19069a4d3b8db55bfe6220cf634d5
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FCGR2A NCF2 CHD1 DDX60L CLEC2B

8.49e-061996259da8b48ec1c1c105fcbab6ae8f08166e7d5e8a35
ToppCellCOVID-19_Severe-Neu_1|World / 5 Neutrophil clusters in COVID-19 patients

TET2 FCGR2A NCF2 DDX60L CLEC2B

8.49e-06199625e4d8bf016fd95a440e30014a75587e097e90cfad
ToppCellBiopsy_IPF-Immune-Monocytes|Biopsy_IPF / Sample group, Lineage and Cell type

TET2 NLRP12 FCGR2A NCF2 CHD1

8.70e-0620062580b2b7eecc5dce9d22f9c80562e4aea83bbf0f50
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SBF2 DIP2C ZNF57 KIR2DL4

6.31e-05154624ba55a63cfa5e0fb9dfec794f80078a2f0d03d0ad
ToppCell356C-Myeloid-Monocyte-CD16+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

YOD1 CDC42BPG DLGAP2 SULT2A1

8.64e-051676247e61c5d2cdcfa6a2e3484b3994aec6b64ad75f07
ToppCell10x5'-GI_small-bowel-Myeloid_Monocytic|GI_small-bowel / Manually curated celltypes from each tissue

PLBD1 NLRP12 FCGR2A NCF2

9.46e-05171624098a7fd387357c0d4e1a6169af4d24ef95b30018
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Neutrophil|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NLRP12 FCGR2A NCF2 CLEC2B

9.46e-05171624ef9397cec7f5c217d34583f26270af7ed7fbcebf
ToppCell10x5'-GI_small-bowel-Myeloid_Monocytic-Classical_monocytes|GI_small-bowel / Manually curated celltypes from each tissue

PLBD1 NLRP12 FCGR2A NCF2

1.01e-0417462405d54a36772f096047521e16a89cc42ae48d2a1d
ToppCell3'-Adult-Distal_Rectal-Epithelial-Tuft-related-Microfold_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA3 ARHGAP28 NCF2 MYBPC1

1.03e-041756248a37b2811f39bb9baa537e8755a29d559eb8185a
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLBD1 THG1L NUDCD3 NCOA4

1.10e-04178624be4976bbfd9ebbc568155ede99a07670c43aa372
ToppCell3'-Adult-Distal_Rectal-Epithelial-Tuft-related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA3 ARHGAP28 NCF2 MYBPC1

1.10e-04178624a95bb77a2c2ce7c38989e6f971812f7ee9f5bd4b
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLBD1 THG1L NUDCD3 NCOA4

1.10e-0417862491bf3c7c05d2e67ee590389a1b36c517d0ed7ebf
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRKAA1 MYO1B NCF2 PTGIS

1.13e-04179624f99500c4a590e5152ded5862690f7fa614d64a80
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRKAA1 MYO1B NCF2 PTGIS

1.13e-041796247d61466181ab73088de3ec8a129d7cfa8cac7ecc
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRKAA1 MYO1B NCF2 PTGIS

1.13e-041796246c98ce32cb55cf9cee557449e41b23bdb22f5efd
ToppCellnormal_Lymph_Node-Myeloid_cells-Pleural_Mac|normal_Lymph_Node / Location, Cell class and cell subclass

PLBD1 NLRP12 FCGR2A NCF2

1.18e-04181624921e917f83105896ad8918dc134b871708024021
ToppCellLPS-IL1RA+antiTNF-Myeloid-Neutrophils|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLBD1 NLRP12 FCGR2A NCF2

1.20e-04182624243c783675df495ea4112dbf710712c44ea6b4f1
ToppCellLPS-IL1RA+antiTNF-Myeloid-Neutrophils-Neutrophils|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLBD1 NLRP12 FCGR2A NCF2

1.20e-0418262418790a394dc32b3cef99cdbf826392c520e38b4a
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NLRP12 FCGR2A NCF2 CHD1

1.23e-04183624cff3197e9ff401362501db2317c86adc6d24b595
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NLRP12 FCGR2A NCF2 CHD1

1.23e-04183624f803dd2881ceaed6327e21a1a51bc3d3ccf4b5f8
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NLRP12 FCGR2A NCF2 CHD1

1.23e-041836244bd6883daf2dbe8c1b49b776b48d41f9890d1cb4
ToppCellNS-moderate-d_07-13-Myeloid-Neutrophil|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FCGR2A NCF2 DDX60L CLEC2B

1.25e-041846244c7d05f1a4556b13cedbaaf88d67ac32d09b109b
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FCGR2A NCF2 DDX60L CLEC2B

1.28e-04185624f30fb9d75cdb757b206312992aaf7485bc900f96
ToppCellproximal-3-Hematologic-Myeloid_Dendritic_Type_1|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MAP3K14 SIRT7 PTGIS KNL1

1.31e-04186624c920dffd24f051b54d8b48f801fffc928d99e135
ToppCellproximal-Hematologic-Myeloid_Dendritic_Type_1-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MAP3K14 SIRT7 PTGIS KNL1

1.31e-04186624d740aca5dc4240851ba7bc5988c0970d785ad0c2
ToppCellproximal-Hematologic-Myeloid_Dendritic_Type_1|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MAP3K14 SIRT7 PTGIS KNL1

1.31e-041866244ca7f6c043874a0c536f75af5ca24c7c66725e54
ToppCellLPS-IL1RA+antiTNF-Myeloid|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLBD1 NLRP12 FCGR2A NCF2

1.34e-041876244e0bbef6ba0d1b3e1f8d900d4a9dbd41f09a7bc5
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

ZNF407 CHD1 CHORDC1 EIF2AK3

1.36e-04188624ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell3'_v3-GI_small-bowel-Myeloid_Monocytic-Classical_monocytes|GI_small-bowel / Manually curated celltypes from each tissue

PLBD1 NLRP12 FCGR2A NCF2

1.39e-0418962474a5e61cd820f2495dde40e766c771a31d8c4e7d
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TET2 PLBD1 NLRP12 NCF2

1.39e-0418962455aba1ebc012006a5db3ff9c92589cb3d9f7c68a
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

LPCAT3 MAP3K14 CHD1 CHORDC1

1.51e-04193624dbf0fe496254320c894568c31e5f9ce63707d1b5
ToppCellMacrophages-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

PLBD1 FCGR2A NCF2 CLEC2B

1.51e-0419362418534bd60bdd1ce51f948380c78017679931b8b1
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

THRB SBF2 ARHGAP28 MAP3K1

1.54e-04194624b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCellMacrophages-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

PLBD1 FCGR2A NCF2 CLEC2B

1.54e-0419462454fda501ce1d041285d04c3c96c15983f454bed4
ToppCellMNPs|World / lung cells shred on cell class, cell subclass, sample id

PLBD1 FCGR2A NCF2 CLEC2B

1.57e-04195624bd84ceae79115afd13346d8d66da30232a0952a9
ToppCellmild-Myeloid-Neutrophils_3|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PLBD1 NLRP12 FCGR2A NCF2

1.57e-04195624a1cfed0092debcc003eff6a62508556b7664d5e1
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-myeloid|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PLBD1 NLRP12 FCGR2A NCF2

1.57e-04195624b0dbaae86f5703ab62f925e0f36500274044884a
ToppCellPBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PLBD1 NLRP12 FCGR2A NCF2

1.57e-041956240110b976f98561ecd2e20ff6e7e3960a401bb7c2
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PLBD1 NLRP12 FCGR2A NCF2

1.57e-04195624580ed65b4152483b642a7e7dbdf00d03588c46f6
ToppCellControl-Classical_Monocyte-cMono_2|Control / Disease condition and Cell class

PLBD1 FCGR2A NCF2 NCOA4

1.57e-041956240fea64ee3eedf3929abb0dd9c5f5fc72f181eed9
ToppCellPBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLBD1 NLRP12 FCGR2A NCF2

1.57e-04195624050fc59b328391d6e3ce23051764a842dcbb3144
ToppCellVE-granulo1-|VE / Condition, Cell_class and T cell subcluster

DLGAP2 PLBD1 FCGR2A NCF2

1.60e-04196624ab3f2ce294c7e503d86254a195be0cf500a2c5e4
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLBD1 FCGR2A NCF2 NCOA4

1.60e-041966241d170422a9eb5e477ce837f9da1c7db95ee5da1c
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FCGR2A NCF2 DDX60L CLEC2B

1.60e-041966246230b4a26770d30f1ab83345c087f03be1be0f9e
ToppCelldistal-Epithelial-Alveolar_Epithelial_Type_1-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CDC42BPG SULT2A1 LAMA3 MYO1B

1.60e-04196624b74dbdfc8d9b85d7cae5c6a49b56347b15ce16e1
ToppCellCOVID-19_Severe-Neu_0|COVID-19_Severe / 5 Neutrophil clusters in COVID-19 patients

FCGR2A NCF2 DDX60L CLEC2B

1.60e-041966244831243fcd680cf4821fa0246e758c3e7c13a962
ToppCellCOVID-19-Myeloid-Transitioning_MDM|COVID-19 / group, cell type (main and fine annotations)

TET2 FCGR2A SBF2 NCF2

1.60e-041966244929cfed1f150c1fde4d79cb49895c2ea467a18f
ToppCellVE-granulo1|VE / Condition, Cell_class and T cell subcluster

DLGAP2 PLBD1 FCGR2A NCF2

1.60e-041966246dbd3acb30173d7f0b7bca0a82f435f00ca85835
ToppCellChildren_(3_yrs)-Immune-monocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

TET2 NLRP12 SBF2 MAP3K1

1.60e-04196624cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FCGR2A NCF2 DDX60L CLEC2B

1.60e-04196624d9b5eaca4089d5337f1175a663418c9c675cdd87
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLBD1 FCGR2A NCF2 CHORDC1

1.60e-041966245fe6534af65d43eeacd4b031310242b4f706008b
ToppCellILEUM-non-inflamed-(3)_Resident_macrophages|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PLBD1 FCGR2A NCF2 NCOA4

1.63e-041976243af24354b6a93c7d105b9fa6549cf215107b9203
ToppCellCOVID-granulo1-|COVID / Condition, Cell_class and T cell subcluster

TET2 PLBD1 NLRP12 NCF2

1.63e-04197624190392117dc6269a21983bd3e554066fd48acd5e
ToppCelldistal-1-Epithelial-Alveolar_Epithelial_Type_1|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CDC42BPG SULT2A1 LAMA3 MYO1B

1.63e-04197624d44b7dc7c6416ed9466889374c3ae39f43ac8bb6
ToppCellCOVID-granulo1|COVID / Condition, Cell_class and T cell subcluster

TET2 PLBD1 NLRP12 NCF2

1.63e-041976244cd774d9d5a6bf7729dc6b7bcd3ddfe3f3051ada
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Classical_Monocyte|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLBD1 FCGR2A NCF2 NCOA4

1.63e-041976242afc23f7394d9b40bdf06527c5e6b553e1b02dca
ToppCell10x_3'_v3-blood_(10x_3'_v3)|10x_3'_v3 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PLBD1 NLRP12 NCF2 NCOA4

1.63e-041976242d3547107c88c7443fc6425742694e13368a71f5
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FCGR2A NCF2 DDX60L CLEC2B

1.63e-04197624037f5f26fa66818baa35846aa96336155e8a6f45
ToppCellILEUM-non-inflamed-(3)_MNP|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PLBD1 FCGR2A NCF2 NCOA4

1.63e-0419762464fdc12e7ffade669cc1de081b10e84a27f0d1b5
ToppCellControl-Classical_Monocyte-cMono_2|Classical_Monocyte / Disease condition and Cell class

PLBD1 FCGR2A NCF2 NCOA4

1.63e-04197624eb7610c9496a95a5fd866e16abcbc39b83abe617
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TET2 FCGR2A NCF2 CHD1

1.63e-04197624f431f11196dc4332933b5d71c7c7408d54c2dedc
ToppCellCOVID-19_Moderate-Classical_Monocyte|COVID-19_Moderate / disease group, cell group and cell class

PLBD1 NLRP12 FCGR2A NCF2

1.63e-0419762498d4107e457e7399a84439acd73bf8f59598971b
ToppCellcritical-Myeloid-Neutrophil|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FCGR2A NCF2 DDX60L CLEC2B

1.63e-04197624f1248781e71e3a158d06e9ec93eb90dc6d48bcb2
ToppCellcontrol-Myeloid-Neutrophils_2|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

FCGR2A NCF2 DDX60L CLEC2B

1.63e-041976248819db1550bf14566c6d33d97f7f83419e867ace
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TET2 NLRP12 FCGR2A NCF2

1.63e-041976241eb9ff8467118b943b5d443cb996168e1e1206b5
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLBD1 FCGR2A NCF2 NCOA4

1.63e-0419762415bcfe6105c0b508811fb9bba0bc4312fea04f4c
ToppCellCOVID-19_Moderate-Classical_Monocyte|World / disease group, cell group and cell class

TET2 PLBD1 FCGR2A NCF2

1.63e-0419762416cf3939e700aef1e16159f0652ba2dfad287e7a
ToppCell3'_v3-GI_small-bowel-Myeloid_Monocytic|GI_small-bowel / Manually curated celltypes from each tissue

PLBD1 NLRP12 FCGR2A NCF2

1.63e-04197624dcf0009057576a7db9065e644a3919d6de2ac8e6
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLBD1 FCGR2A NCF2 NCOA4

1.66e-04198624110f7ebb3e1ec19508d4d2b973e1f64e7bdbb5b5
ToppCell10x5'-lymph-node_spleen-Myeloid_Monocytic|lymph-node_spleen / Manually curated celltypes from each tissue

PLBD1 NLRP12 FCGR2A NCF2

1.66e-041986242541f1095ed91e6789cb888cf39a208b8107726a
ToppCellcritical-Myeloid|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FCGR2A NCF2 DDX60L CLEC2B

1.66e-04198624a5807517f8ca93b77f49f5787fd9036178b8fc2a
ToppCellsevere-HLA-DR+_CD83+_Monocyte|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TET2 PLBD1 FCGR2A NCF2

1.66e-04198624a77f3440d7fb6a50066abc7e9ad59e83798ef13d
ToppCellsevere-Myeloid-Neutrophils_2|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

FCGR2A NCF2 DDX60L CLEC2B

1.66e-04198624636878836678a0715550fa09f2e3dac11c4d73fe
ToppCellcellseq2-Immune-Immune_Myeloid-iMON-iMON|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PLBD1 NLRP12 FCGR2A NCF2

1.66e-04198624a6aa113f0af4d25c032f440c3134fe4d88ca5055
ToppCell10x5'-lymph-node_spleen-Myeloid_Monocytic-Classical_monocytes|lymph-node_spleen / Manually curated celltypes from each tissue

PLBD1 NLRP12 FCGR2A NCF2

1.66e-04198624934dacb67d71faa2f8732c39d7f8e64b0ee75396
ToppCellmild-Myeloid|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PLBD1 FCGR2A NCF2 NCOA4

1.66e-04198624908746384e10c6b833bb3bc124045d7b0bfd73b5
ToppCellAdult-Immune|Adult / Lineage, Cell type, age group and donor

FCGR2A SBF2 NCF2 DDX60L

1.66e-041986249bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FCGR2A NCF2 DDX60L CHORDC1

1.66e-0419862493cc01d91ffc543fd1a717ef47e02e532b50b665
ToppCellsevere-Myeloid|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PLBD1 FCGR2A NCF2 DDX60L

1.66e-04198624d19902a6353445f9875dec59933b7553f5145b8b
ToppCellNS-critical-LOC-Myeloid-Neutrophil|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FCGR2A NCF2 DDX60L CLEC2B

1.66e-04198624e56417073e83061a43b9c41d6232d653904c1e90
ToppCellcellseq2-Immune-Immune_Myeloid-iMON|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PLBD1 NLRP12 FCGR2A NCF2

1.66e-04198624a0ceed8689d42be6b9cde89d6c182d10b3fb14fc
ToppCellILEUM-non-inflamed-(3)_DC2|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PLBD1 FCGR2A NCF2 NCOA4

1.66e-0419862434157b3ff2c4867cacde38810999fac279051bc8
ToppCellNS-critical-LOC-Myeloid|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FCGR2A NCF2 DDX60L CLEC2B

1.66e-0419862458f2bc88d92550fb0b7c2e46c63c49ec6777001c
ToppCellNS-critical-d_16-33-Myeloid-Neutrophil|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FCGR2A NCF2 DDX60L CLEC2B

1.66e-04198624fd5dd6d6d72356d4eac8637350405c69ccb7161c
ToppCellSevere-B_intermediate-6|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

PIKFYVE TET2 FCGR2A NCF2

1.66e-041986248402421dc060926e968efe39a4e907f1e8ae5b1f
DiseaseX-13548 measurement

ZMYND11 DIP2C

3.17e-062532EFO_0021353
Diseasemonocyte percentage of leukocytes

SELE PLBD1 NLRP12 DNAH12 THRB MAP3K14 PRKDC MUSK ZMYM4

5.60e-06731539EFO_0007989
Diseasecreatinine measurement

TET2 RAB19 MAP3K14 DIP2C SPATA20 CHORDC1 MUSK DDX1

3.75e-04995538EFO_0004518
Diseaseobsolete_red blood cell distribution width

THRB SULT2A1 LPCAT3 THG1L ZNF407 NCOA4 MUSK MAP3K1 KNL1

6.05e-041347539EFO_0005192
Diseasebasophil percentage of leukocytes

FCGR2A CHD1 PRKDC CHORDC1

9.57e-04243534EFO_0007992
Diseaseprostate cancer (is_implicated_in)

THRB SULT2A1 CHD1

1.23e-03117533DOID:10283 (is_implicated_in)
Diseasemyeloid white cell count

SELE TET2 FCGR2A SBF2 MAP3K14 MYO1B MUSK

1.37e-03937537EFO_0007988
Diseasewaist-hip ratio

TET2 ZMYND11 SBF2 MAP3K14 ZNF407 PTGIS ZMYM4 KNL1

1.46e-031226538EFO_0004343

Protein segments in the cluster

PeptideGeneStartEntry
DWKVMAFSKKGGHLE

EIF2AK3

316

Q9NZJ5
GETIMLRCHSWKDKP

FCGR2A

136

P12318
LKLLHAETKRMEGWC

DLGAP2

871

Q9P1A6
RKKHKDEDWQMSGSG

CHD1

141

O14646
MLIGNKCDLWEKRHV

RAB19

126

A4D1S5
MLHKWEMLKRAETAC

CDC42BPG

101

Q6DT37
KPFDLRSKMGKWCHH

POTEB2

16

H3BUK9
MWRLRCKAKDGTHVL

YOD1

46

Q5VVQ6
RIKSKEKCNDGKWHT

LAMA3

3056

Q16787
HSKIDKAMECVWKQK

NCF2

156

P19878
KVHEMLKKGWDAEGS

NUDCD3

326

Q8IVD9
KKGVCIWECIDRMHK

SBF2

1536

Q86WG5
KSLCMVKCHWKEKQD

LENG8

581

Q96PV6
WKMLKDKFNECGHVL

HNRNPM

666

P52272
MLGLIACFKAWKKHC

DDX60L

626

Q5H9U9
VKEWHGCRATKGLMK

DDX1

116

Q92499
HWRDIMKFCAKDPKV

DNAH12

941

Q6ZR08
DVGMWNDERCSKKKL

SELE

121

P16581
EEKGKAKWDACANMK

LPCAT3

306

Q6P1A2
KNLWEKMRHCSDKEL

KNL1

1976

Q8NG31
AIRKGFLACHLAMWK

PPM1D

141

O15297
SLKVFKRWDMGHCSA

PLBD1

216

Q6P4A8
KRWDMGHCSALIKVL

PLBD1

221

Q6P4A8
MGRKEEDDCSSWKKQ

CAMK1G

1

Q96NX5
KFVMCHLKGLSADRW

FADS2B

236

A8MWK0
KPFDLRSKMGKWCHH

POTEB3

16

A0JP26
LLHRWCSKKKDAAVM

KIR2DL4

261

Q99706
EKHKDSLNMWLCPRK

NCOA4

451

Q13772
KDLWKKICHHSSGME

PIKFYVE

356

Q9Y2I7
AKVACVKSRDMHWAL

DIP2C

586

Q9Y2E4
IWMHAEEREECKGKQ

KLC1

426

Q07866
VAHATEGKMARVCWK

MAP3K14

121

Q99558
REKLKATCMPAWKHE

MAP3K1

186

Q13233
KPFDLRSKMGKWCHH

POTED

16

Q86YR6
DKDHMCSVKSRLWKL

PTGIS

226

Q16647
KPFDLRSKMGKWCHH

POTEB

16

A0A0A6YYL3
KPFVLRSKMGKWCRH

POTEJ

16

P0CG39
HFLSCLDDKQWKMGK

SNX33

331

Q8WV41
KPFVLRSKMGKWCRH

POTEI

16

P0CG38
WAALKLHGKCDDVMR

SIRT7

306

Q9NRC8
AEILCLMHSKGDAKW

SULT2A1

51

Q06520
SWRKMATAEKQKHDG

PRKAA1

6

Q13131
KCSSDHWIGLKMAKN

CLEC2B

86

Q92478
LAQEGCTKGKHMWTK

CHORDC1

206

Q9UHD1
CTKGKHMWTKKDAGK

CHORDC1

211

Q9UHD1
HMWTKKDAGKKVVPC

CHORDC1

216

Q9UHD1
MWGACKVKVHDSLAT

THG1L

1

Q9NWX6
EWEKMKFSEKISCVH

SSX6P

36

Q7RTT6
NADKFKWDKMCHREA

ARHGAP28

441

Q9P2N2
GHKDWMDKCVCLLTA

SPATA20

661

Q8TB22
DWKLVGMSEACLHRK

THRB

26

P10828
WKLLKKDLCNTHLMR

PRKDC

1356

P78527
HVKRSMGWKKACDEL

ZMYND11

336

Q15326
MGWKKACDELELHQR

ZMYND11

341

Q15326
SFKGGWKCKDHTEML

ZNF140

116

P52738
EKPHKCKQCGMSFKW

ZNF57

501

Q68EA5
KECGKLFMWHTAFLK

ZNF594

711

Q96JF6
RKWTALHPGAKKMTE

ULBP1

156

Q9BZM6
HMKLHTGEKPFKCTW

ZNF407

1646

Q9C0G0
DCEKKEKNSWERMRH

TOGARAM1

1196

Q9Y4F4
KHGLALWEAKMAEKA

TET2

1911

Q6N021
KHDLAKRWGNHCKMC

ZMYM4

761

Q5VZL5
EKSLCWKVSPHIKMD

NLRP12

576

P59046
RGWKCRTHFLLMKKS

MYO1B

716

O43795
CAKEWLVMEEKTHRG

MUSK

406

O15146
KGKWMDLASKAGKHL

MYBPC1

96

Q00872