Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	NUT	NUTM2F NUTM2G	1.30e-04	5	68	2	IPR024310
Domain	NUT_N	NUTM2F NUTM2G	1.30e-04	5	68	2	IPR024309
Domain	NUT	NUTM2F NUTM2G	1.30e-04	5	68	2	PF12881
Domain	Znf_CXXC	TET1 KDM2A	7.03e-04	11	68	2	IPR002857
Domain	ZF_CXXC	TET1 KDM2A	7.03e-04	11	68	2	PS51058
Domain	zf-CXXC	TET1 KDM2A	7.03e-04	11	68	2	PF02008
Domain	FBOX	FBXO10 FBH1 KDM2A	8.98e-04	52	68	3	SM00256
Domain	F-box	FBXO10 FBH1 KDM2A	1.87e-03	67	68	3	PF00646
Domain	FBOX	FBXO10 FBH1 KDM2A	2.30e-03	72	68	3	PS50181
Domain	F-box_dom	FBXO10 FBH1 KDM2A	2.58e-03	75	68	3	IPR001810
Domain	ADAM_spacer1	THSD4 ADAMTSL5	3.15e-03	23	68	2	IPR010294
Domain	ADAM_spacer1	THSD4 ADAMTSL5	3.15e-03	23	68	2	PF05986
Domain	-	PLCD3 GDPD3	3.71e-03	25	68	2	3.20.20.190
Domain	PLC-like_Pdiesterase_TIM-brl	PLCD3 GDPD3	3.71e-03	25	68	2	IPR017946
Pubmed	Chondroitin polymerizing factor promotes development and progression of colorectal cancer via facilitating transcription of VEGFB.	CHPF VEGFB	4.23e-06	2	72	2	38775031
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	KSR1 LARP4B CAMKK2 FBXO10 FBH1 CLK3 ARMC5	1.23e-05	372	72	7	22939624
Pubmed	Enhanced angiogenesis in obesity and in response to PPARgamma activators through adipocyte VEGF and ANGPTL4 production.	ANGPTL4 VEGFB	1.27e-05	3	72	2	18728224
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PLCD3 TDRD3 ADAMTSL5 SIPA1L3 AKNA PLEC CHPF REPIN1 RNF43 IQGAP3 C8orf58	1.63e-05	1105	72	11	35748872
Pubmed	Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.	TET1 KDM2A	4.21e-05	5	72	2	21251613
Pubmed	A family of mammalian F-box proteins.	FBXO10 FBH1 KDM2A	9.22e-05	42	72	3	10531037
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	BNC2 TDRD3 LARP4B CAMKK2 SIPA1L3 TET1 ETV6	1.23e-04	536	72	7	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	BNC2 TDRD3 LARP4B CAMKK2 SIPA1L3 TET1 ETV6	1.26e-04	538	72	7	10512203
Pubmed	DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.	TET1 KDM2A	1.88e-04	10	72	2	29276034
Pubmed	Functional proteomics mapping of a human signaling pathway.	PLCD3 MAN1A2 PEG10 KDM2A PLEC CHPF BAG6	2.24e-04	591	72	7	15231748
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	BNC2 ZNF219 TET1 RCOR2	2.46e-04	146	72	4	23892456
Pubmed	Role of Tet1 in erasure of genomic imprinting.	PEG10 TET1	2.75e-04	12	72	2	24291790
Pubmed	SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay.	TDRD3 C2orf68	3.25e-04	13	72	2	20930030
Pubmed	FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress.	FBXO10 FBH1	3.78e-04	14	72	2	23319600
Pubmed	Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.	CACNA1B BSN	3.78e-04	14	72	2	21228161
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KSR1 AMER1 CLK3 SIPA1L3 TET1 PLEC ATAT1 KIF1C	4.04e-04	861	72	8	36931259
Pubmed	A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.	ZNF219 ELOA2 SRSF12	4.77e-04	73	72	3	22094256
Pubmed	Bioinformatics and cellular signaling.	PIK3AP1 ERRFI1 BAG6 VEGFB	5.66e-04	182	72	4	15102471
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	CACNA1B CAMKK2 SRD5A1 PLEC KIF1C EZHIP	5.76e-04	496	72	6	31343991
Pubmed	The protein interaction landscape of the human CMGC kinase group.	LARP4B CLK3 BCLAF1 SIPA1L3 ATAT1 BAG6 SRSF12	5.91e-04	695	72	7	23602568
Pubmed	Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses.	ELOA2 ERRFI1	7.06e-04	19	72	2	16705022
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	CACNA1B CAMKK2 PLEC BSN SAMD14	7.78e-04	347	72	5	17114649
Pubmed	A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.	ELOA2 RCOR2	8.65e-04	21	72	2	19345177
Pubmed	A multipotent progenitor domain guides pancreatic organogenesis.	ZNF219 ETV6 RNF43	9.07e-04	91	72	3	17609113
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	TDRD3 LARP4B NOL6 BAG6 IQGAP3	9.63e-04	364	72	5	24778252
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PLCD3 TDRD3 LARP4B MAN1A2 CLK3 SIPA1L3 NOL6 ETV6 REPIN1 IQGAP3	1.00e-03	1497	72	10	31527615
Pubmed	A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.	PIK3AP1 ZAP70	1.04e-03	23	72	2	22761313
Pubmed	Large-scale concatenation cDNA sequencing.	ACD PEG10 SRD5A1 RITA1 SAMD14 SLC12A5	1.16e-03	568	72	6	9110174
Pubmed	A "double adaptor" method for improved shotgun library construction.	ACD PEG10 SRD5A1 RITA1 SAMD14 SLC12A5	1.22e-03	574	72	6	8619474
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	TDRD3 LARP4B CLK3 BCLAF1 PEG10 SRSF12 KIF1C	1.41e-03	807	72	7	22681889
Pubmed	SOSTDC1 promotes invasion and liver metastasis in colorectal cancer via interaction with ALCAM/CD166.	PIK3AP1 PLEC	1.54e-03	28	72	2	32801337
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	LARP4B NOL6 BAG6 SRSF12	1.91e-03	253	72	4	29911972
Pubmed	A pancreatic cancer-specific expression profile.	GDPD3 PLEC	2.01e-03	32	72	2	8895530
Pubmed	Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models.	TET1 BAG6	2.01e-03	32	72	2	27739607
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	LARP4B BCLAF1 PEG10 KIF1C	2.05e-03	258	72	4	37794589
Cytoband	16p11.2	GDPD3 ZNF764 ARMC5 SLX1A	2.39e-04	191	72	4	16p11.2
GeneFamily	ADAMTS like	THSD4 ADAMTSL5	1.15e-04	7	43	2	947
GeneFamily	Zinc fingers CXXC-type	TET1 KDM2A	3.59e-04	12	43	2	136
Disease	PROSTATE CANCER, HEREDITARY, 1	LARP4B KDM2A ATAT1 RNF43	9.53e-06	60	65	4	C4722327
Disease	Prostate cancer, familial	LARP4B KDM2A ATAT1 RNF43	1.66e-05	69	65	4	C2931456
Disease	epilepsy (implicated_via_orthology)	CACNA1B ETNK2 BSN SLC12A5	4.67e-04	163	65	4	DOID:1826 (implicated_via_orthology)
Disease	prostate carcinoma	LARP4B BCLAF1 SIPA1L3 KDM2A BSN ATAT1 RNF43 EZHIP	7.38e-04	891	65	8	EFO_0001663
Disease	red blood cell density measurement	THSD4 LARP4B ZNF219 ETV6 KDM2A PLEC ZNF503-AS2	3.18e-03	880	65	7	EFO_0007978
Disease	ovarian neoplasm	BNC2 CAMKK2 RNF43	3.26e-03	134	65	3	C0919267
Disease	Malignant neoplasm of ovary	BNC2 CAMKK2 RNF43	3.47e-03	137	65	3	C1140680
Disease	cups of coffee per day measurement	CLK3 STRA6	3.53e-03	40	65	2	EFO_0006782
Disease	high grade glioma (is_marker_for)	CAMKK2 RNF43	3.89e-03	42	65	2	DOID:3070 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PVDPAHNVSRLHRLP	ANGPTL4	171	Q9BY76
HRAPRQLPAARCSHS	ACADL	16	P28330
NLACTPPRHLHVVRP	BAG6	346	P46379
RNRHSANPNPRLHMP	BNC2	486	Q6ZN30
RPHLENSLRRPSAAH	FBXO10	911	Q9UK96
PHLSALRAQPARAAH	CLK3	31	P49761
RARPHEHVSSAPQVP	AMER1	201	Q5JTC6
PAPRARPTLHSRHRE	ARMC5	606	Q96C12
LNRICRRSHHHPEPP	C8orf58	306	Q8NAV2
PLLQRAFHPPHRVVR	PIK3AP1	86	Q6ZUJ8
LPRHRDVSAHPRNPD	C2orf68	71	Q2NKX9
APEGVDPPRRHHRHR	CACNA1B	841	Q00975
SQYRHHPLRTRRRPP	RCOR2	246	Q8IZ40
PPRRRRHCNRAPLTH	HERV-K104	11	P61576
HNPPTIELLHRSRSP	ETV6	171	P41212
RTPELPPSSAHRSHL	ANOS1	651	P23352
ATAPRSPSHSPEHRR	ELOA2	116	Q8IYF1
LPRIPSSDCHPRRHS	LNP1	56	A1A4G5
FPHRATHLDPARLSP	EZHIP	246	Q86X51
YPPRSRNPSKSHLRH	LARP4B	406	Q92615
PHRATPAELRSHALP	BSN	1841	Q9UPA5
SAPQPRASFHLRRHT	ETNK2	6	Q9NVF9
HSFITPPTTPQLRRH	KSR1	266	Q8IVT5
PRHIPRHRQAVDSPA	NOL6	1016	Q9H6R4
RSPPRALVLPHIASH	PEG10	251	Q86TG7
PSPRRSHHPRRNSLD	KIF1C	1021	O43896
PHLLHTPRAPTFRIR	GDPD3	26	Q7L5L3
ARHRPPSTALQAHSP	PRDM12	321	Q9H4Q4
PPPTRFHRVHGANIR	NEURL2	21	Q9BR09
PPCPDTRGRAHRLLH	ADAMTSL5	361	Q6ZMM2
APHPPLSVVRRFAHL	IQGAP3	846	Q86VI3
HRARLRGQLPSSPTH	PLEKHG6	686	Q3KR16
KAPRHHLSVPCTRPR	FBH1	146	Q8NFZ0
RRHFPPSARRIDPQH	IGSF10	741	Q6WRI0
HSPRVLVQHCPARTP	KDM2A	831	Q9Y2K7
RHHVRCHAAPRPNPA	C7orf61	181	Q8IZ16
PSQNSPIHHIPSRRS	BCLAF1	286	Q9NYF8
ASPPPARRHRHSIQL	AKNA	1376	Q7Z591
PPSFPHHRATLRLSE	MAN1A2	21	O60476
AHQHRPPAPSLRATR	ATAT1	191	Q5SQI0
PPAPSLRATRHSRAA	ATAT1	196	Q5SQI0
SSPRLPRRPTVESHH	CAMKK2	136	Q96RR4
PESRRHSVADPRHLP	SLC12A5	21	Q9H2X9
VSPRLVHFSARRGPH	KCTD11	96	Q693B1
HHRLRPWRLSQSPVP	NUTM2F	646	A1L443
HHRLRPWRLSQSPVP	NUTM2G	631	Q5VZR2
HLRHPPRNDTRQPRN	TDRD3	316	Q9H7E2
RHHRFPRAAHPRAPG	RNF43	386	Q68DV7
SSTLPARRQHQHPHP	SIPA1L3	1581	O60292
SPSFVRRHPRAEPHS	SAMD14	151	Q8IZD0
NPPPPQTHRRLRRSH	ERRFI1	236	Q9UJM3
RHPCSPSDHRRSRSP	SRSF12	101	Q8WXF0
SHSPRPREAPLRAIH	RITA1	151	Q96K30
LDLSPLHRSPHPSRQ	STRA6	401	Q9BX79
RAHLRRCHPPAPEAR	REPIN1	161	Q9BWE0
TPVEHPNRNHPTRLS	TET1	2031	Q8NFU7
RSHVPSPHQALVTRP	ACD	351	Q96AP0
PHFRSALTAHPVRDP	CHPF	316	Q8IZ52
RHPEPRRTEHRAPSS	CLEC1A	31	Q8NC01
HSFRHGRPTVPRQPL	C10orf105	101	Q8TEF2
IRIHPARRHPARNGS	ZNF503-AS2	46	A6NEH8
PAHPSTLTHPQRRID	ZAP70	271	P43403
SRRPLAHHDPPVAIR	PRR19	36	A6NJB7
HATRLRTLHPAPNAP	PLCD3	536	Q8N3E9
PIPPTHRRVHSKASQ	WDR97	951	A6NE52
RRPRSLHPHVPGVTN	PLEC	31	Q15149
RRRSPPRFHTGHHPR	U2AF1L4	191	Q8WU68
DRAATPHHRPQPRSV	VEGFB	136	P49765
TCPRRGHLPRFHPRT	SLC46A2	6	Q9BY10
HALPSHRLRVPARAA	SRD5A1	41	P18405
QHPHASRRLAHVGPR	SLX1A	86	Q9BQ83
VRHPDRFSPHRPDNL	THSD4	591	Q6ZMP0
HKHRPAPRLQPSRTS	PVRIG	196	Q6DKI7
RSHLRTHQPERPRSP	ZNF219	101	Q9P2Y4
SLCAHPPVPRADQRH	ZNF764	161	Q96H86