Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	FBLN5 DSG2 SYT17 NBPF26 ITGB1 LDLR EGFEM1P C2CD5 EYS FBN2 CDH20 LRP2 UMOD C1R ADGRE5 LTBP3 FBN3	1.05e-06	749	113	17	GO:0005509
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	ERBB2 ARHGEF28 MYO5B SYT17 SLITRK4 DOCK10 SHTN1 NRN1 ITGB1 UNC5A KANK1 NRXN3 HECW2 LRP2 USP33	2.65e-05	819	109	15	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	ERBB2 ARHGEF28 MYO5B SYT17 SLITRK4 DOCK10 SHTN1 NRN1 ITGB1 UNC5A KANK1 NRXN3 HECW2 LRP2 USP33	2.93e-05	826	109	15	GO:0048858
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	ERBB2 ARHGEF28 MYO5B SLITRK4 DOCK10 TECTA SHTN1 NRN1 ITGB1 UNC5A NRXN3 HECW2 LRP2 USP33	3.99e-05	748	109	14	GO:0048667
GeneOntologyBiologicalProcess	cell morphogenesis	ERBB2 ARHGEF28 MYO5B SYT17 SLITRK4 DOCK10 TECTA SHTN1 NRN1 ITGB1 ITGB6 UNC5A KANK1 NRXN3 CDH20 HECW2 LRP2 USP33	5.18e-05	1194	109	18	GO:0000902
GeneOntologyBiologicalProcess	neuron projection morphogenesis	ERBB2 ARHGEF28 MYO5B SYT17 SLITRK4 DOCK10 SHTN1 NRN1 ITGB1 UNC5A NRXN3 HECW2 LRP2 USP33	8.42e-05	802	109	14	GO:0048812
Domain	EGF-like_CS	ATRN FBLN5 ITGB1 LDLR ITGB6 TMEFF2 EYS NRXN3 FBN2 MALRD1 LRP2 UMOD C1R LTBP3 C9 FBN3 EPHA1	3.89e-13	261	114	17	IPR013032
Domain	EGF-like_dom	ATRN FBLN5 TECTA LDLR TMEFF2 EYS NRXN3 FBN2 MALRD1 LRP2 UMOD C1R ADGRE5 LTBP3 C9 FBN3	2.48e-12	249	114	16	IPR000742
Domain	EGF_1	ATRN FBLN5 ITGB1 LDLR ITGB6 TMEFF2 EYS NRXN3 FBN2 MALRD1 LRP2 UMOD C1R LTBP3 C9 FBN3	3.56e-12	255	114	16	PS00022
Domain	EGF_2	ATRN FBLN5 LDLR ITGB6 TMEFF2 EYS NRXN3 FBN2 MALRD1 LRP2 UMOD C1R LTBP3 C9 FBN3 EPHA1	6.39e-12	265	114	16	PS01186
Domain	Growth_fac_rcpt_	ATRN ERBB2 FBLN5 LDLR EYS FBN2 LRP2 UMOD ADGRE5 LTBP3 C9 FBN3 EPHA1	1.22e-11	156	114	13	IPR009030
Domain	EGF	ATRN FBLN5 TECTA LDLR TMEFF2 EYS NRXN3 FBN2 MALRD1 LRP2 UMOD C1R ADGRE5 LTBP3 FBN3	1.39e-11	235	114	15	SM00181
Domain	EGF_3	ATRN FBLN5 LDLR TMEFF2 EYS NRXN3 FBN2 MALRD1 LRP2 UMOD C1R ADGRE5 LTBP3 C9 FBN3	1.39e-11	235	114	15	PS50026
Domain	DUF1220	NBPF3 NBPF11 NBPF1 NBPF15 NBPF9 NBPF14	2.04e-11	11	114	6	PF06758
Domain	NBPF_dom	NBPF3 NBPF11 NBPF1 NBPF15 NBPF9 NBPF14	2.04e-11	11	114	6	IPR010630
Domain	NBPF	NBPF3 NBPF11 NBPF1 NBPF15 NBPF9 NBPF14	2.04e-11	11	114	6	PS51316
Domain	ASX_HYDROXYL	FBLN5 LDLR EYS NRXN3 FBN2 LRP2 UMOD C1R ADGRE5 LTBP3 FBN3	2.41e-11	100	114	11	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	FBLN5 LDLR EYS NRXN3 FBN2 LRP2 UMOD C1R ADGRE5 LTBP3 FBN3	4.58e-11	106	114	11	IPR000152
Domain	EGF_Ca-bd_CS	FBLN5 LDLR EYS FBN2 LRP2 UMOD C1R ADGRE5 LTBP3 FBN3	3.88e-10	97	114	10	IPR018097
Domain	EGF_CA	FBLN5 LDLR EYS FBN2 LRP2 UMOD C1R ADGRE5 LTBP3 FBN3	4.75e-10	99	114	10	PS01187
Domain	DUF1220	NBPF3 NBPF11 NBPF1 NBPF15 NBPF9	9.58e-10	9	114	5	SM01148
Domain	EGF_CA	FBLN5 LDLR FBN2 LRP2 UMOD C1R ADGRE5 LTBP3 FBN3	2.65e-09	86	114	9	PF07645
Domain	EGF_CA	FBLN5 LDLR EYS FBN2 LRP2 UMOD C1R ADGRE5 LTBP3 FBN3	3.74e-09	122	114	10	SM00179
Domain	EGF-like_Ca-bd_dom	FBLN5 LDLR EYS FBN2 LRP2 UMOD C1R ADGRE5 LTBP3 FBN3	4.38e-09	124	114	10	IPR001881
Domain	EGF	ATRN TECTA TMEFF2 EYS NRXN3 MALRD1 LRP2 UMOD FBN3	7.75e-08	126	114	9	PF00008
Domain	cEGF	FBLN5 FBN2 LRP2 LTBP3 FBN3	4.61e-07	26	114	5	PF12662
Domain	cEGF	FBLN5 FBN2 LRP2 LTBP3 FBN3	4.61e-07	26	114	5	IPR026823
Domain	TB	FBN2 LTBP3 FBN3	7.61e-06	7	114	3	PF00683
Domain	-	FBN2 LTBP3 FBN3	1.21e-05	8	114	3	3.90.290.10
Domain	TB_dom	FBN2 LTBP3 FBN3	1.81e-05	9	114	3	IPR017878
Domain	TB	FBN2 LTBP3 FBN3	1.81e-05	9	114	3	PS51364
Domain	hEGF	EYS FBN2 LTBP3 FBN3	2.41e-05	28	114	4	PF12661
Domain	LDLR_class-A_CS	LDLR MALRD1 LRP2 C9	1.02e-04	40	114	4	IPR023415
Domain	Tubulin-bd_cofactor_C_dom	RP2 TBCC	1.10e-04	3	114	2	IPR012945
Domain	TBCC	RP2 TBCC	1.10e-04	3	114	2	PF07986
Domain	FBN	FBN2 FBN3	1.10e-04	3	114	2	IPR011398
Domain	Ldl_recept_a	LDLR MALRD1 LRP2 C9	1.62e-04	45	114	4	PF00057
Domain	-	LDLR MALRD1 LRP2 C9	1.76e-04	46	114	4	4.10.400.10
Domain	LDLRA_1	LDLR MALRD1 LRP2 C9	2.08e-04	48	114	4	PS01209
Domain	-	ITGB1 ITGB6	2.20e-04	4	114	2	1.20.5.630
Domain	LDrepeatLR_classA_rpt	LDLR MALRD1 LRP2 C9	2.26e-04	49	114	4	IPR002172
Domain	LDLa	LDLR MALRD1 LRP2 C9	2.26e-04	49	114	4	SM00192
Domain	LDLRA_2	LDLR MALRD1 LRP2 C9	2.26e-04	49	114	4	PS50068
Domain	CAP/MinC_C	RP2 TBCC	3.65e-04	5	114	2	IPR016098
Domain	CARP_motif	RP2 TBCC	3.65e-04	5	114	2	IPR006599
Domain	-	RP2 TBCC	3.65e-04	5	114	2	2.160.20.70
Domain	C-CAP_CF_C-like	RP2 TBCC	3.65e-04	5	114	2	IPR017901
Domain	CARP	RP2 TBCC	3.65e-04	5	114	2	SM00673
Domain	C_CAP_COFACTOR_C	RP2 TBCC	3.65e-04	5	114	2	PS51329
Domain	EGF_extracell	ATRN ITGB1 ITGB6 LRP2	4.93e-04	60	114	4	IPR013111
Domain	EGF_2	ATRN ITGB1 ITGB6 LRP2	4.93e-04	60	114	4	PF07974
Domain	DUSP	USP4 USP33	5.45e-04	6	114	2	PF06337
Domain	Integrin_b_cyt	ITGB1 ITGB6	5.45e-04	6	114	2	SM01241
Domain	Integrin_b_cyt	ITGB1 ITGB6	5.45e-04	6	114	2	PF08725
Domain	DUSP	USP4 USP33	5.45e-04	6	114	2	SM00695
Domain	Integrin_bsu_cyt_dom	ITGB1 ITGB6	5.45e-04	6	114	2	IPR014836
Domain	DUSP	USP4 USP33	7.60e-04	7	114	2	PS51283
Domain	Integrin_B_tail	ITGB1 ITGB6	7.60e-04	7	114	2	SM01242
Domain	Integrin_bsu_tail	ITGB1 ITGB6	7.60e-04	7	114	2	IPR012896
Domain	-	USP4 USP33	7.60e-04	7	114	2	3.30.2230.10
Domain	Pept_C19_DUSP	USP4 USP33	7.60e-04	7	114	2	IPR006615
Domain	Integrin_B_tail	ITGB1 ITGB6	7.60e-04	7	114	2	PF07965
Domain	INB	ITGB1 ITGB6	1.01e-03	8	114	2	SM00187
Domain	Integrin_bsu_VWA	ITGB1 ITGB6	1.01e-03	8	114	2	IPR002369
Domain	Integrin_beta	ITGB1 ITGB6	1.01e-03	8	114	2	PF00362
Domain	Integrin_bsu	ITGB1 ITGB6	1.29e-03	9	114	2	IPR015812
Domain	INTEGRIN_BETA	ITGB1 ITGB6	1.29e-03	9	114	2	PS00243
Domain	PSI_integrin	ITGB1 ITGB6	1.29e-03	9	114	2	PF17205
Domain	Integin_beta_N	ITGB1 ITGB6	1.29e-03	9	114	2	IPR033760
Domain	SOCS_box	TULP4 ASB10 SOCS5	1.60e-03	38	114	3	PF07525
Domain	ZP_dom_CS	TECTA UMOD	1.61e-03	10	114	2	IPR017977
Domain	SOCS_box	TULP4 ASB10 SOCS5	1.72e-03	39	114	3	SM00969
Domain	SOCS_box	TULP4 ASB10 SOCS5	1.72e-03	39	114	3	IPR001496
Domain	SOCS	TULP4 ASB10 SOCS5	1.72e-03	39	114	3	PS50225
Domain	PSI	ATRN ITGB1 ITGB6	2.44e-03	44	114	3	IPR016201
Domain	PSI	ATRN ITGB1 ITGB6	2.78e-03	46	114	3	SM00423
Domain	TIL_dom	TECTA LRP2	3.20e-03	14	114	2	IPR002919
Domain	ZP_2	TECTA UMOD	3.20e-03	14	114	2	PS51034
Domain	ZP_1	TECTA UMOD	3.20e-03	14	114	2	PS00682
Domain	Ldl_recept_b	LDLR LRP2	3.20e-03	14	114	2	PF00058
Domain	LDLRB	LDLR LRP2	3.20e-03	14	114	2	PS51120
Domain	LY	LDLR LRP2	3.68e-03	15	114	2	SM00135
Domain	ZP	TECTA UMOD	3.68e-03	15	114	2	SM00241
Domain	LDLR_classB_rpt	LDLR LRP2	3.68e-03	15	114	2	IPR000033
Domain	ZP_dom	TECTA UMOD	4.73e-03	17	114	2	IPR001507
Domain	Zona_pellucida	TECTA UMOD	4.73e-03	17	114	2	PF00100
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	FBLN5 ITGB1 ITGB6 FBN2 LTBP3 FBN3	6.48e-08	37	82	6	M27134
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	FBLN5 ITGB1 ITGB6 FBN2 LTBP3 FBN3	1.90e-07	44	82	6	M26969
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	FBLN5 ITGB1 ITGB6 FBN2 LTBP3	1.05e-06	32	82	5	MM14854
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	FBLN5 ITGB1 ITGB6 FBN2 LTBP3	2.90e-06	39	82	5	MM14601
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF3 NBPF8 NBPF12 NBPF11 NBPF1 NBPF15 NBPF9 NBPF10 NBPF14	1.82e-17	21	123	9	16079250
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF8 NBPF12 NBPF1 NBPF15 NBPF9 NBPF14	3.59e-13	10	123	6	22973535
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	NBPF8 NBPF12 NBPF11 NBPF1 NBPF9 SOCS5 SYNE2 NBPF10 NBPF14	1.05e-08	170	123	9	23314748
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ATRN ERBB2 URI1 PDE4D FRMPD2 FRMPD1 PPARA TECTA SHTN1 INTS8 ITGB1 HNRNPF TMEFF2 NBPF1 HIPK3 RLF USF3 PWWP2B TULP4 BOD1L1 SPIDR	6.04e-08	1489	123	21	28611215
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ERBB2 C5orf22 DSG2 RALGAPA2 ANKHD1 LDLR C2CD5 NSD3 ZNF518A PASK MLH3 PWWP2B ARHGEF33 FBN2 BRCA1 LTN1 LRP2	4.37e-07	1116	123	17	31753913
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	AKAP6 RHBDF1 FRMPD1 ANKHD1 ITGB1 LDLR HNRNPF C2CD5 SOCS5 LTN1 LRP2 ADGRE5 BOD1L1 RP2 NUP153 KIF11	1.48e-06	1084	123	16	11544199
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DMXL2 ARHGEF28 MYO5B RALGAPA2 C2CD5 USF3 TULP4 SOCS5 LTN1 FHDC1 SPIDR	1.54e-06	493	123	11	15368895
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	NBPF8 NBPF12 RBKS NBPF11 TECTA HNRNPF NBPF1 NBPF15 NBPF9 NBPF10 NBPF14	2.25e-06	513	123	11	25798074
Pubmed	655Val and 1170Pro ERBB2 SNPs in familial breast cancer risk and BRCA1 alterations.	ERBB2 BRCA1	1.24e-05	2	123	2	17452776
Pubmed	Blood HER2 and Uromodulin as Causal Mediators of CKD.	ERBB2 UMOD	1.24e-05	2	123	2	29511113
Pubmed	DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries.	FBLN5 LDLR	1.24e-05	2	123	2	10428823
Pubmed	Fibulin-5 regulates keloid-derived fibroblast-like cells through integrin beta-1.	FBLN5 ITGB1	1.24e-05	2	123	2	26095157
Pubmed	Spontaneous epithelial-mesenchymal transition and resistance to HER-2-targeted therapies in HER-2-positive luminal breast cancer.	ERBB2 ITGB1	1.24e-05	2	123	2	23991019
Pubmed	Meteorin-like/Meteorin-β protects heart against cardiac dysfunction.	METRNL PPARA	1.24e-05	2	123	2	33635944
Pubmed	Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice.	PPARA LDLR	1.24e-05	2	123	2	12847522
Pubmed	Haploinsufficiency in the PPARalpha and LDL receptor genes leads to gender- and age-specific obesity and hyperinsulinemia.	PPARA LDLR	1.24e-05	2	123	2	17011521
Pubmed	Constitutional translocation t(1;17)(p36.31-p36.13;q11.2-q12.1) in a neuroblastoma patient. Establishment of somatic cell hybrids and identification of PND/A12M2 on chromosome 1 and NF1/SCYA7 on chromosome 17 as breakpoint flanking single copy markers.	NBPF11 NBPF1	1.24e-05	2	123	2	7700633
Pubmed	Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.	PPARA LDLR	1.24e-05	2	123	2	17724261
Pubmed	beta1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression.	ERBB2 ITGB1	1.24e-05	2	123	2	20713705
Pubmed	Expression of breast cancer type 1 and its relation with expression of estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2/neu in breast carcinoma on trucut biopsy specimens.	ERBB2 BRCA1	1.24e-05	2	123	2	29567881
Pubmed	Molecular mechanism of age-specific hepatic lipid accumulation in PPARalpha (+/-):LDLR (+/-) mice, an obese mouse model.	PPARA LDLR	1.24e-05	2	123	2	18335269
Pubmed	Activation of PPARα Ameliorates Cardiac Fibrosis in Dsg2-Deficient Arrhythmogenic Cardiomyopathy.	DSG2 PPARA	1.24e-05	2	123	2	36291052
Pubmed	Milk cholesterol concentration in mice is not affected by high cholesterol diet- or genetically-induced hypercholesterolaemia.	LDLR ABCG8	1.24e-05	2	123	2	29891894
Pubmed	A Survey of Rare Epigenetic Variation in 23,116 Human Genomes Identifies Disease-Relevant Epivariations and CGG Expansions.	LDLR BRCA1	1.24e-05	2	123	2	32937144
Pubmed	Transgenic mouse models of human breast cancer.	ERBB2 BRCA1	1.24e-05	2	123	2	11156526
Pubmed	Megalin (gp330): a putative endocytic receptor for thyroglobulin (Tg).	TG LRP2	1.24e-05	2	123	2	9492085
Pubmed	Loss of fibulin-5 binding to beta1 integrins inhibits tumor growth by increasing the level of ROS.	FBLN5 ITGB1	1.24e-05	2	123	2	20197418
Pubmed	Expression of HER2 and BRCA1 Correlates with Prognosis in Patients with Breast Cancer After Radiotherapy: A Case-Control Study.	ERBB2 BRCA1	1.24e-05	2	123	2	33112672
Pubmed	Myeloid interferon-γ receptor deficiency does not affect atherosclerosis in LDLR(-/-) mice.	LDLR IFNGR2	1.24e-05	2	123	2	26828750
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AKAP6 KDM3A ERBB2 SANBR ANKHD1 ZFYVE28 PASK NRXN3 HECW2 SENP6	1.97e-05	529	123	10	14621295
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	ERBB2 ITGB1 LDLR ITGB6 LRP2	3.08e-05	101	123	5	23382219
Pubmed	Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation.	MYO5B ITGB1 LDLR	3.39e-05	18	123	3	32496646
Pubmed	Polymorphisms in 33 inflammatory genes and risk of myocardial infarction--a system genetics approach.	ITGB1 TNFRSF1B	3.71e-05	3	123	2	17634906
Pubmed	cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3.	AKAP6 PDE4D	3.71e-05	3	123	2	20106966
Pubmed	Integrin alpha5/beta1 expression mediates HER-2 down-regulation in colon cancer cells.	ERBB2 ITGB1	3.71e-05	3	123	2	15757908
Pubmed	Association of Germline Genetic Testing Results With Locoregional and Systemic Therapy in Patients With Breast Cancer.	ERBB2 BRCA1	3.71e-05	3	123	2	32027353
Pubmed	Tesaglitazar, a dual peroxisome proliferator-activated receptor alpha/gamma agonist, reduces atherosclerosis in female low density lipoprotein receptor deficient mice.	PPARA LDLR	3.71e-05	3	123	2	17214992
Pubmed	Protein kinase A and phosphodiesterase-4D3 binding to coding polymorphisms of cardiac muscle anchoring protein (mAKAP).	AKAP6 PDE4D	3.71e-05	3	123	2	23806656
Pubmed	Clinicopathological features and BRCA1 and BRCA2 mutation status in a prospective cohort of young women with breast cancer.	ERBB2 BRCA1	3.71e-05	3	123	2	34703009
Pubmed	Megalin/LRP2 expression is induced by peroxisome proliferator-activated receptor -alpha and -gamma: implications for PPARs' roles in renal function.	PPARA LRP2	3.71e-05	3	123	2	21311715
Pubmed	Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects.	UMOD KNG1	3.71e-05	3	123	2	18455532
Pubmed	Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited.	LDLR ABCG8	3.71e-05	3	123	2	17060690
Pubmed	Effective treatment of HER2-amplified breast cancer by targeting HER3 and β1 integrin.	ERBB2 ITGB1	3.71e-05	3	123	2	26860947
Pubmed	Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK-SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue.	PPARA PASK	3.71e-05	3	123	2	35011564
Pubmed	Placental DNA Methylation Adaptation to Maternal Glycemic Response in Pregnancy.	LDLR TNFRSF1B	3.71e-05	3	123	2	29752424
Pubmed	From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer.	ERBB2 BRCA1	3.71e-05	3	123	2	25176624
Pubmed	A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation.	ARHGEF28 ITGB1	3.71e-05	3	123	2	24006257
Pubmed	Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia.	ERBB2 LDLR	3.71e-05	3	123	2	28759039
Pubmed	Low prevalence of HER2 positivity amongst BRCA1 and BRCA2 mutation carriers and in primary BRCA screens.	ERBB2 BRCA1	3.71e-05	3	123	2	26888723
Pubmed	Differential Gene Expression of BRCA1,ERBB2 and TP53 biomarkers between Human Breast Tissue and Peripheral Blood Samples of Breast Cancer.	ERBB2 BRCA1	3.71e-05	3	123	2	26299666
Pubmed	Angiotensinogen and Megalin Interactions Contribute to Atherosclerosis-Brief Report.	LDLR LRP2	3.71e-05	3	123	2	30567480
Pubmed	c-erbB2-induced disruption of matrix adhesion and morphogenesis reveals a novel role for protein kinase B as a negative regulator of alpha(2)beta(1) integrin function.	ERBB2 ITGB1	3.71e-05	3	123	2	12181354
Pubmed	Prevalence of germline BRCA mutations in HER2-negative metastatic breast cancer: global results from the real-world, observational BREAKOUT study.	ERBB2 BRCA1	3.71e-05	3	123	2	33109210
Pubmed	Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor.	PPARA LDLR	3.71e-05	3	123	2	16794006
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	ATRN DSG2 ITGB1 LDLR C1R C9 KNG1	3.80e-05	257	123	7	16335952
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	URI1 C5orf22 DSG2 ANKHD1 FAAP100 ITGB1 C2CD5 PASK FBN2 LTN1 BOLA2 NUP153 KIF11	4.32e-05	974	123	13	28675297
Pubmed	Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas.	ITGB1 ITGB6	7.41e-05	4	123	2	11668187
Pubmed	Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi population.	ERBB2 BRCA1	7.41e-05	4	123	2	27068824
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN2 FBN3	7.41e-05	4	123	2	25034023
Pubmed	Phenotypic analysis of familial breast cancer: comparison of BRCAx tumors with BRCA1-, BRCA2-carriers and non-familial breast cancer.	ERBB2 BRCA1	7.41e-05	4	123	2	25736863
Pubmed	The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.	AKAP6 PDE4D	7.41e-05	4	123	2	16177794
Pubmed	Nup153 and Nup50 promote recruitment of 53BP1 to DNA repair foci by antagonizing BRCA1-dependent events.	BRCA1 NUP153	7.41e-05	4	123	2	28751496
Pubmed	mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module.	AKAP6 PDE4D	7.41e-05	4	123	2	11296225
Pubmed	Effects of high dietary fat and cholesterol on expression of PPAR alpha, LXR alpha, and their responsive genes in the liver of apoE and LDLR double deficient mice.	PPARA LDLR	7.41e-05	4	123	2	19067122
Pubmed	Neuregulin-1 enhances motility and migration of human astrocytic glioma cells.	ERBB2 ITGB1	7.41e-05	4	123	2	12600989
Pubmed	Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3.	RP2 TBCC	7.41e-05	4	123	2	12417528
Pubmed	CCR7-CCL19/CCL21 Axis is Essential for Effective Arteriogenesis in a Murine Model of Hindlimb Ischemia.	LDLR CCL19	7.41e-05	4	123	2	28275068
Pubmed	Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology.	ERBB2 ITGB1	7.41e-05	4	123	2	12118253
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	ATRN ERBB2 FBLN5 DSG2 SLITRK4 NBPF26 ITGB1 LDLR FBN2 LTN1 BOLA2 ADGRE5 LTBP3 LRRFIP1	9.26e-05	1201	123	14	35696571
Pubmed	Neuregulin-1/glial growth factor stimulates Schwann cell migration by inducing α5 β1 integrin-ErbB2-focal adhesion kinase complex formation.	ERBB2 ITGB1	1.23e-04	5	123	2	24256316
Pubmed	Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms.	BRCA1 LTN1	1.23e-04	5	123	2	27977889
Pubmed	Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer.	ERBB2 BRCA1	1.23e-04	5	123	2	20177704
Pubmed	NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.	NSD3 BOD1L1	1.23e-04	5	123	2	26626481
Pubmed	Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma.	NBPF11 NBPF1	1.23e-04	5	123	2	20096688
Pubmed	Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling.	ERBB2 ITGB1	1.23e-04	5	123	2	27519953
Pubmed	Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.	LDLR LRP2	1.23e-04	5	123	2	18685438
Pubmed	Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor.	ITGB1 ITGB6	1.23e-04	5	123	2	8120056
Pubmed	Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage retention.	LDLR CCL19	1.23e-04	5	123	2	23430613
Pubmed	αv integrin processing interferes with the cross-talk between αvβ5/β6 and α2β1 integrins.	ITGB1 ITGB6	1.23e-04	5	123	2	21787362
Pubmed	Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.	ERBB2 PIK3C2A	1.23e-04	5	123	2	10805725
Pubmed	Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.	FBLN5 FBN2	1.23e-04	5	123	2	17255108
Pubmed	Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation.	ITGB1 ITGB6	1.23e-04	5	123	2	19448673
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZDBF2 ANKHD1 SHTN1 RLF ATF7IP2 LRP2 BOLA2 KIF11	1.26e-04	418	123	8	34709266
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	ERBB2 SWT1 SYT17 DOCK10 EYS HECW2 ATF7IP2 EPHA1	1.30e-04	420	123	8	28065597
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ERBB2 RHBDF1 PPARA RALGAPA2 ANKHD1 FAAP100 LDLR NBPF1 NSD3 PWWP2B TULP4 LTBP3 SNAPC4	1.53e-04	1105	123	13	35748872
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	AKAP6 DMXL2 DOCK10 ZNF518A PASK SYNE2	1.55e-04	225	123	6	12168954
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	SWT1 ITGB1 ITGB6 IFNGR2 SYNE2 UMOD ADGRE5 CCL19 TNFRSF1B SNAPC4 C9	1.72e-04	824	123	11	20237496
Pubmed	Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice.	LDLR SOCS5	1.84e-04	6	123	2	24255059
Pubmed	Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.	LDLR LRP2	1.84e-04	6	123	2	9837937
Pubmed	Methylation of CLDN6, FBN2, RBP1, RBP4, TFPI2, and TMEFF2 in esophageal squamous cell carcinoma.	TMEFF2 FBN2	1.84e-04	6	123	2	19288010
Pubmed	alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity.	ITGB1 ITGB6	1.84e-04	6	123	2	17158881
Pubmed	p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling.	ERBB2 BRCA1	1.84e-04	6	123	2	16951165
Pubmed	Cloning of mouse integrin alphaV cDNA and role of the alphaV-related matrix receptors in metanephric development.	ITGB1 ITGB6	1.84e-04	6	123	2	8601592
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	DSG2 ZDBF2 SHTN1 ITGB1 ITGB6 SCARA5 SYNE2 NUP153 USP33	1.96e-04	568	123	9	37774976
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	RHBDF1 DSG2 SLITRK4 RALGAPA2 ITGB1 ITGB6 KLHL38 RP2 EPHA1	1.99e-04	569	123	9	30639242
Pubmed	Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C.	RP2 TBCC	2.58e-04	7	123	2	11847227
Pubmed	Transcriptional repression of atherogenic inflammation: modulation by PPARdelta.	PPARA LDLR	2.58e-04	7	123	2	12970571
Pubmed	Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5.	HNRNPF KIF11	2.58e-04	7	123	2	27557628
Pubmed	The primitive endoderm segregates from the epiblast in β1 integrin-deficient early mouse embryos.	ITGB1 LRP2	2.58e-04	7	123	2	24277939
Pubmed	Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains.	ITGB1 ITGB6	2.58e-04	7	123	2	8798654
Cytoband	1q21.1	NBPF8 NBPF11 NBPF9 NBPF10 NBPF14	7.28e-07	62	123	5	1q21.1
Cytoband	2q32.3	TMEFF2 HECW2	4.62e-04	12	123	2	2q32.3
GeneFamily	Neuroblastoma breakpoint family	NBPF3 NBPF8 NBPF12 NBPF26 NBPF11 NBPF1 NBPF15 NBPF9 NBPF10 NBPF14	2.93e-18	23	84	10	662
GeneFamily	CD molecules\|Integrin beta subunits	ITGB1 ITGB6	7.52e-04	9	84	2	1159
GeneFamily	Low density lipoprotein receptors	LDLR LRP2	1.61e-03	13	84	2	634
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	ATRN KDM3A DMXL2 URI1 LDLR C2CD5 RLF ORC5 BRCA1 PIK3C2A SOCS5 SYNE2 LTN1 SPIDR NBPF14 NUP153 KIF11 LRRFIP1	1.05e-07	856	123	18	M4500
Coexpression	IWANAGA_CARCINOGENESIS_BY_KRAS_UP	URI1 LDLR HIPK3 IFNGR2 NRXN3 FBN2 BOD1L1 EPHA1	1.96e-06	177	123	8	M9118
Coexpression	IWANAGA_CARCINOGENESIS_BY_KRAS_UP	URI1 LDLR HIPK3 IFNGR2 NRXN3 FBN2 BOD1L1 EPHA1	3.60e-06	192	123	8	MM752
Coexpression	ZHENG_BOUND_BY_FOXP3	KDM3A LRRC66 FBLN5 DOCK10 SHTN1 C2CD5 NSD3 TG USF3 SYNE2 NUP153	2.37e-05	498	123	11	M1741
Coexpression	ZHENG_BOUND_BY_FOXP3	KDM3A LRRC66 FBLN5 DOCK10 SHTN1 C2CD5 NSD3 TG USF3 SYNE2 NUP153	2.79e-05	507	123	11	MM1030
ToppCell	Control-B_intermediate-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF12 NBPF11 NBPF1 NSD3 NBPF15 USF3 NBPF10	1.55e-07	144	123	7	984470ff6ddce4c743e2db78fa98dae055aaa273
ToppCell	Control-B_intermediate-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF12 NBPF11 NBPF1 NSD3 NBPF15 USF3 NBPF10	4.23e-07	167	123	7	948504367ecf58144d9dd74d2ec531358fc4b309
ToppCell	droplet-Lung-30m-Epithelial-alveolar_epithelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYO5B DSG2 PPARA NRN1 ITGB6 LRP2 FHDC1	6.51e-07	178	123	7	76e71fff99cf64302e2e3c0d66dd8ba0ff13624e
ToppCell	droplet-Lung-30m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYO5B DSG2 PPARA NRN1 ITGB6 LRP2 FHDC1	6.51e-07	178	123	7	82f78ea1ea3ff3e2347cd8bc2f06e2a10e96f220
ToppCell	droplet-Lung-30m-Epithelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYO5B DSG2 PPARA NRN1 ITGB6 LRP2 FHDC1	6.51e-07	178	123	7	5442bc52b8e902da1383f44d97a9f95e471a8d4d
ToppCell	droplet-Lung-30m-Epithelial-alveolar_epithelial-type_II_pneumocyte\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYO5B DSG2 PPARA NRN1 ITGB6 LRP2 FHDC1	6.51e-07	178	123	7	523b286ebe0359c7f1902f28cbd71f452626fc0d
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE4D ARHGEF28 MYO5B KCTD16 SYNE2 LRP2 PAPPA	7.01e-07	180	123	7	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D MYO5B KANK1 KCTD16 SYNE2 LRP2 PAPPA	8.74e-07	186	123	7	b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell	Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|World / Lineage, Cell type, age group and donor	PDE4D MYO5B ITGB6 TMEFF2 KANK1 MALRD1 FBN3	1.04e-06	191	123	7	d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D ARHGEF28 MYO5B ITGB6 KANK1 SYNE2 LRP2	1.16e-06	194	123	7	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	Transverse-Dendritic_cell-Lymphoid_DC\|Dendritic_cell / Region, Cell class and subclass	FBLN5 SYT17 RALGAPA2 COG6 FHDC1 CCL19 SNAPC4	1.28e-06	197	123	7	8545baf923ddf84c5ce9414a36d810603be52401
ToppCell	Control_saline-Epithelial_alveolar-AT_1\|Control_saline / Treatment groups by lineage, cell group, cell type	ERBB2 MYO5B METRNL NRXN3 FBN2 SYNE2 LTBP3	1.33e-06	198	123	7	9b161285df7a4e51618f3517cfc5b8221ba55786
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	ERBB2 MYO5B SHTN1 LDLR NRXN3 SYNE2 LTBP3	1.42e-06	200	123	7	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	Mild/Remission-B_naive-1\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF11 NBPF1 NSD3 NBPF15 USF3 NBPF10	2.90e-06	143	123	6	bd3f5fbd4e9e4dc414682db5607494f3ce988deb
ToppCell	droplet-Lung-nan-3m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	METRNL RBKS LDLR IFNGR2 RP2 TNFRSF1B	3.28e-06	146	123	6	ed932d43e9efd064ee4b49ddef529f3d041be765
ToppCell	droplet-Lung-nan-3m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	METRNL RBKS LDLR IFNGR2 RP2 TNFRSF1B	3.28e-06	146	123	6	0d74962779055c774312d59fc3b1365163741c3a
ToppCell	Control-B_naive-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF11 NBPF1 NSD3 NBPF15 USF3 NBPF10	4.62e-06	155	123	6	0a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB2 FBLN5 FRMPD1 NRN1 RAB3IL1 KNG1	5.75e-06	161	123	6	9f02b94e29e60d50e92eaa748ebf0c36d3671bb3
ToppCell	Control\|World / group, cell type (main and fine annotations)	ARHGEF28 MYO5B LDLR KANK1 NRXN3 LRP2	7.34e-06	168	123	6	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	Control-B_naive-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF11 NBPF1 NSD3 NBPF15 USF3 NBPF10	8.12e-06	171	123	6	d18855b24aadea38fd1e4592f945cf15b85e05f1
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DMXL2 DOCK10 SHTN1 ATF7IP2 TNFRSF1B KIF11	9.89e-06	177	123	6	67cc3a6461db5e0678f96b18224aeb83ad34b0f4
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF28 MYO5B LDLR ITGB6 NRXN3 SYNE2	1.05e-05	179	123	6	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DSG2 NBPF26 SHTN1 MALRD1 NBPF10 ABCG8	1.09e-05	180	123	6	7c7c4d64ff99d0710a7d19d8bc29fc9217394db1
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	AKAP6 PPARA MALRD1 KCTD16 UMOD KNG1	1.09e-05	180	123	6	9e09b3dfe344b5d50520711513d389865d73a861
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLITRK4 DOCK10 EGFEM1P FBN2 SCARA5 FBN3	1.12e-05	181	123	6	35bcdcd2651149692e5b150e887c0f450c81d2d4
ToppCell	Brain_organoid-organoid_Kanton_Nature\|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.	ANKRD36C LDLR NSD3 ZNF518A ANKRD36B SYNE2	1.27e-05	185	123	6	857c7ca8493e91ef1d0078ddafd6082020f9b169
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE4D ARHGEF28 MYO5B SYNE2 LRP2 PAPPA	1.35e-05	187	123	6	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	AKAP6 PDE4D ARHGEF28 DOCK10 ADGRE5 LRRFIP1	1.39e-05	188	123	6	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	PDE4D MYO5B SYT17 LDLR ITGB6 KANK1	1.39e-05	188	123	6	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D MYO5B KANK1 KCTD16 SYNE2 LRP2	1.43e-05	189	123	6	28b502611829e4a24caff2562545c7db97686099
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG2 PPARA ITGB1 ZNF518A SYNE2 SENP6	1.52e-05	191	123	6	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG2 PPARA ITGB1 ZNF518A SYNE2 SENP6	1.52e-05	191	123	6	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG2 PPARA ITGB1 ZNF518A SYNE2 SENP6	1.52e-05	191	123	6	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	PDE4D LDLR ITGB6 KANK1 LRP2 FHDC1	1.57e-05	192	123	6	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	DOCK10 ANKRD36C LDLR ANKRD36B SYNE2 ADGRE5	1.57e-05	192	123	6	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	PDE4D ITGB6 KANK1 NRXN3 LRP2 FHDC1	1.57e-05	192	123	6	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PDE4D LDLR ITGB6 KANK1 LRP2 FHDC1	1.62e-05	193	123	6	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PDE4D ANKHD1 TG SPIDR C9 NBPF14	1.62e-05	193	123	6	779276e775cb2492e8dd36436295a536084a6415
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D ARHGEF28 MYO5B PPARA KANK1 LRP2	1.62e-05	193	123	6	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D ARHGEF28 MYO5B PPARA KANK1 LRP2	1.62e-05	193	123	6	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PDE4D LDLR ITGB6 KANK1 LRP2 FHDC1	1.62e-05	193	123	6	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-suprabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF28 MYO5B CHCHD7 METRNL DLGAP4 SYNE2	1.66e-05	194	123	6	a3adcdc8b87332e8beb9bcd70cf36424af10633d
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PDE4D MYO5B LDLR ITGB6 KANK1 ATF7IP2	1.66e-05	194	123	6	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D ARHGEF28 MYO5B PPARA ITGB6 KANK1	1.66e-05	194	123	6	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	Control-Lymphoid-CD4_T_cells\|Lymphoid / Condition, Lineage and Cell class	PDE4D PASK NBPF15 PIK3C2A SYNE2 ATF7IP2	1.71e-05	195	123	6	8679a122fe796b1eddef82460e985b3fd3b3a2a5
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PDE4D MYO5B LDLR ITGB6 KANK1 ATF7IP2	1.71e-05	195	123	6	9406866f99555198a9be311fbd65751b70f35446
ToppCell	AT2_cells-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	PDE4D ITGB6 NRXN3 LRP2 C1R PAPPA	1.81e-05	197	123	6	fd7bdfa6bf5966ebc11fdd13915769429540ddbf
ToppCell	Transverse-(5)_Dendritic_cell-(53)_Lymphoid_DC\|Transverse / shred on region, Cell_type, and subtype	DMXL2 DSG2 SYT17 SANBR FHDC1 CCL19	1.81e-05	197	123	6	15b87fd3906d7388c271d30d0c64b1bcc490801c
ToppCell	11.5-Airway-Mesenchymal-Mesenchyme_SERPINF1-high\|Airway / Age, Tissue, Lineage and Cell class	FBLN5 TMEFF2 FBN2 SCARA5 C1R PAPPA	1.81e-05	197	123	6	9a053a32ff9c3a85ef9a3382453acd619cc48546
ToppCell	Transverse-Dendritic_cell-Lymphoid_DC\|Transverse / Region, Cell class and subclass	DMXL2 DSG2 SYT17 SANBR FHDC1 CCL19	1.81e-05	197	123	6	a58af0ea82f76f2a7abac1f62629ff20d552fc63
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	ERBB2 MYO5B NRXN3 FBN2 SYNE2 LTBP3	1.87e-05	198	123	6	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Mesothelial-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	ZNF521 ZDBF2 MLH3 CCL19 C9 KIF11	1.87e-05	198	123	6	9b1a58fcf818f9c4ae57bbe99655f0a64fe87df7
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE4D LDLR ITGB6 KANK1 LRP2 FHDC1	1.92e-05	199	123	6	2dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MYO5B ANKRD36C EYS NRXN3 FBN2 SCARA5	1.97e-05	200	123	6	a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCell	Macroglial-Oligodendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DOCK10 SHTN1 TMEFF2 NRXN3 HECW2 LRP2	1.97e-05	200	123	6	4dbac2f2587e87ca5a0622f50439bb5447e93c7f
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-TYR-L2-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DOCK10 EGFEM1P KANK1 FBN2 SCARA5 FBN3	1.97e-05	200	123	6	04954fbe1e2264077228bb582c9a5897a70e6da2
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MYO5B ANKRD36C EYS NRXN3 FBN2 SCARA5	1.97e-05	200	123	6	33b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCell	Macroglial-Oligodendrocytes-OPALIN--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DOCK10 SHTN1 TMEFF2 NRXN3 HECW2 LRP2	1.97e-05	200	123	6	26b989e30bbbaf30904ced03f6aae3dea25c732c
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-TYR\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DOCK10 EGFEM1P KANK1 FBN2 SCARA5 FBN3	1.97e-05	200	123	6	bfdafb024a7b20d46837b2e6480dd4929253cd62
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FBLN5 ZNF521 SCARA5 KCTD16 C1R PAPPA	1.97e-05	200	123	6	cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCell	Macroglial-Oligodendrocytes-OPALIN---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DOCK10 SHTN1 TMEFF2 NRXN3 HECW2 LRP2	1.97e-05	200	123	6	1314664c1721e9ecb1e2c3482a039044b0fe50a9
ToppCell	Macroglial-Oligodendrocytes-OPALIN-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DOCK10 SHTN1 TMEFF2 NRXN3 HECW2 LRP2	1.97e-05	200	123	6	8b229f095fc113aecfc94b64862a9e0fdcc363ce
ToppCell	LPS_only-Epithelial_alveolar-AT_1\|LPS_only / Treatment groups by lineage, cell group, cell type	ERBB2 MYO5B SHTN1 LDLR NRXN3 SYNE2	1.97e-05	200	123	6	9a6ae40f3e17cd44ee5fd73260713b920aa2ea15
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MYO5B ANKRD36C EYS NRXN3 FBN2 SCARA5	1.97e-05	200	123	6	9719fabddc34051949468a7520289e3c750de4f8
ToppCell	Macroglial-Oligodendrocytes-OPALIN----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DOCK10 SHTN1 TMEFF2 NRXN3 HECW2 LRP2	1.97e-05	200	123	6	272909f4354f3ae22e2b2f8f35970e6b0e92cfe2
ToppCell	Macroglial-Oligodendrocytes-OPALIN\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DOCK10 SHTN1 TMEFF2 NRXN3 HECW2 LRP2	1.97e-05	200	123	6	5f75a9b8bcd49d9bbb1e9ce2de730eaec96369ca
ToppCell	Severe-B_intermediate-1\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF11 NBPF1 NSD3 USF3 NBPF10	2.64e-05	126	123	5	42a0bdbe18ef85146cac4e86b2b27d0b3b20d8a2
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO5B LDLR ITGB6 NRXN3 SYNE2	2.74e-05	127	123	5	5b0adbcafad31a6759c9bdce2f7f9591a8edc450
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MALRD1 SCARA5 NBPF10 RAB3IL1 FBN3	6.66e-05	153	123	5	d5f5399ebbbff508c96ce7f01272716b61597ab5
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MALRD1 SCARA5 NBPF10 RAB3IL1 FBN3	6.66e-05	153	123	5	32cf4ca828d228f23366480305592f9813fed7ff
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	FAM131A USF3 SCARA5 SENP6 KIF11	6.87e-05	154	123	5	1c62290a2558fd6401b27de5a867d243b143b00a
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D SYT17 DOCK10 NRXN3 FBN3	7.53e-05	157	123	5	c17c5c01fcb65c453690c265ec4f300ecdfefd34
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_dendritic-CD141-positive_myeloid_dendritic_cell\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DSG2 ZNF521 ERVMER34-1 EGFEM1P MALRD1	7.76e-05	158	123	5	4f3ea658e032555c2098d016475381c8d1071699
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARHGEF28 TG NBPF15 COG6 EPHA1	7.99e-05	159	123	5	b9d34b9ed8db798f5ea93c44b469cae499403cb8
ToppCell	Severe-B_naive-1\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF1 NSD3 NBPF15 USF3 NBPF10	7.99e-05	159	123	5	2881b054bbeb479221ee3c38bbd9b0815b123579
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDM3A METRNL ITGB1 USF3 TNFRSF1B	8.48e-05	161	123	5	3f3a2148c8d65e6a06f8d8116a3aa58dda17d618
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_dendritic\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DSG2 ZNF521 ERVMER34-1 EGFEM1P MALRD1	8.73e-05	162	123	5	233011408f022647932c81ebab78f9813e3c6833
ToppCell	facs-Spleen-nan-18m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC66 ASB10 FHDC1 RAB3IL1 KIF11	9.79e-05	166	123	5	8d535fab019356894b4dad3fbdbc4d2ad3e16082
ToppCell	facs-Spleen-nan-18m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC66 ASB10 FHDC1 RAB3IL1 KIF11	9.79e-05	166	123	5	f56b1c0d6cb5353a16a2598bda905287f16d2c39
ToppCell	facs-Spleen-nan-18m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC66 ASB10 FHDC1 RAB3IL1 KIF11	9.79e-05	166	123	5	a5074c96c6561273029aceb93402a7e038140f50
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDE4D DOCK10 ANKRD36C PASK SYNE2	1.01e-04	167	123	5	83969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_1\|Classical_Monocyte / Disease condition and Cell class	NBPF11 NSD3 USF3 KCTD16 SYNE2	1.04e-04	168	123	5	d50078614f7af74dc2aa4081c1708a5156ac51cf
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NBPF3 PDE4D FBN2 C1R PAPPA	1.06e-04	169	123	5	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	METRNL PPARA SHTN1 RLF LTN1	1.13e-04	171	123	5	26b34dc069cc15b75a0c13cb8c5d81e074788160
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRMPD1 DOCK10 TMEFF2 EYS KIF25	1.16e-04	172	123	5	3a37569a5902f3c65ff8d3912421309a8c82ee9b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRMPD1 DOCK10 TMEFF2 EYS KIF25	1.16e-04	172	123	5	cc9d9dae290f11f8c348c78228af4e49469dc93b
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DMXL2 METRNL DOCK10 SHTN1 TNFRSF1B	1.19e-04	173	123	5	279efbab7810fa60ab12ea5d09a84800df4adef0
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SYT17 FRMPD2 NRN1 CDH20 C1R	1.19e-04	173	123	5	5aa4d45a01d2d09eff8b4deb32bd91ab2471210a
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MYO5B ITGB6 TMEFF2 MALRD1 ATF7IP2	1.19e-04	173	123	5	b799c06a6a5754668e789f70c0c8bc1508568575
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DSG2 SYT17 DOCK10 NRXN3 FBN3	1.22e-04	174	123	5	5f4436863a40f8bca46e2989bca66c02b6be88d4
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_1\|Classical_Monocyte / Disease condition and Cell class	SHTN1 NBPF1 NSD3 USF3 NBPF10	1.25e-04	175	123	5	35ea2ed93538e6bf803029fcf7d9243f93e7733d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DSG2 SYT17 DOCK10 NRXN3 FBN3	1.25e-04	175	123	5	77c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DSG2 SYT17 DOCK10 NRXN3 FBN3	1.25e-04	175	123	5	98947a226b5a2ac7091ff9d34243ea7736add973
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DSG2 SYT17 DOCK10 NRXN3 FBN3	1.29e-04	176	123	5	25ebc8716aa44e44fce577701e3e82c6745a75ab
ToppCell	droplet-Lung-LUNG-30m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG2 NRN1 ITGB6 LRP2 FHDC1	1.29e-04	176	123	5	5201f003192c033655ba47f0faf8c47a96eae03d
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DMXL2 METRNL DOCK10 SHTN1 TNFRSF1B	1.29e-04	176	123	5	6548797336c9f4ca0f38e74a2c629e2a4defa252
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DMXL2 SHTN1 BRCA1 ATF7IP2 TNFRSF1B	1.29e-04	176	123	5	450c25ec5eeb65425f904e0a25aaafdf5682ef9c
ToppCell	COVID-19-kidney-CD-IC-A\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ARHGEF28 DSG2 SYT17 NRXN3 FBN3	1.29e-04	176	123	5	45028197364c64e93e3ffe86aff773d47a477d49
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	FBLN5 SCARA5 C1R PAPPA CCL19	1.29e-04	176	123	5	510f9a14dc1c151d24d079e0cc004cdf4f86336c
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DMXL2 DOCK10 SHTN1 TG TNFRSF1B	1.29e-04	176	123	5	b0b87eebcf5c994386b39ca607e17f10e9d9de74
Drug	Pesticides	NBPF8 NBPF12 NBPF11 NBPF1 NSD3 NBPF15 NBPF9 NBPF10 NBPF14	1.19e-07	150	122	9	ctd:D010575
Drug	AC1L1J6H	ITGB1 LDLR HNRNPF MLH3 PIK3C2A SCARA5 LRP2 TNFRSF1B ABCG8	5.24e-06	236	122	9	CID000004889
Disease	connective tissue disease (implicated_via_orthology)	FBN2 FBN3	4.43e-05	3	114	2	DOID:65 (implicated_via_orthology)
Disease	creatinine measurement, glomerular filtration rate	EGFEM1P CDH20 LRP2 UMOD C9	9.36e-05	117	114	5	EFO_0004518, EFO_0005208
Disease	body weight	AKAP6 LRRC66 CHCHD7 ZNF521 SHTN1 TMEFF2 EYS USF3 NRXN3 FBN2 TULP4 SENP6 PAPPA LTBP3	3.66e-04	1261	114	14	EFO_0004338
Disease	Malignant neoplasm of breast	AKAP6 KDM3A ERBB2 FRMPD1 FAM131A TECTA CDH20 BRCA1 SYNE2 DNAJC24 BOD1L1 LRRFIP1	9.29e-04	1074	114	12	C0006142
Disease	autoimmune thyroiditis (is_implicated_in)	TG LRP2	9.52e-04	12	114	2	DOID:7188 (is_implicated_in)
Disease	Hirschsprung's disease (implicated_via_orthology)	ERBB2 ITGB1	9.52e-04	12	114	2	DOID:10487 (implicated_via_orthology)
Disease	Allergic Reaction	CCL19 TNFRSF1B KNG1	1.88e-03	63	114	3	C1527304
Disease	Lipidemias	PPARA LDLR	1.94e-03	17	114	2	C1706412
Disease	sphingomyelin 14:0 measurement	PDE4D SYNE2	1.94e-03	17	114	2	EFO_0010390
Disease	Hyperlipidemia	PPARA LDLR	1.94e-03	17	114	2	C0020473
Disease	rheumatoid arthritis, COVID-19	IFNGR2 COG6 CCL19	1.97e-03	64	114	3	EFO_0000685, MONDO_0100096
Disease	Hypersensitivity	CCL19 TNFRSF1B KNG1	1.97e-03	64	114	3	C0020517
Disease	Coronary Arteriosclerosis	LDLR PAPPA ABCG8	2.06e-03	65	114	3	C0010054
Disease	Coronary Artery Disease	LDLR PAPPA ABCG8	2.06e-03	65	114	3	C1956346
Disease	Neoplasms, Experimental	ERBB2 URI1 KIF11	2.15e-03	66	114	3	C0027659
Disease	Age-related macular degeneration	FBLN5 C9	2.17e-03	18	114	2	cv:C0242383
Disease	Hypercholesterolemia, Familial	LDLR ABCG8	2.17e-03	18	114	2	C0020445
Disease	Animal Mammary Neoplasms	ERBB2 PPARA BRCA1 KNG1	2.28e-03	142	114	4	C0024667
Disease	Mammary Carcinoma, Animal	ERBB2 PPARA BRCA1 KNG1	2.28e-03	142	114	4	C1257925
Disease	Non-alcoholic Fatty Liver Disease	PPARA LDLR TNFRSF1B	2.55e-03	70	114	3	C0400966
Disease	Nonalcoholic Steatohepatitis	PPARA LDLR TNFRSF1B	2.55e-03	70	114	3	C3241937
Disease	sucrose liking measurement	ORC5 CDH20	2.69e-03	20	114	2	EFO_0010157
Disease	cortisol measurement	LDLR EGFEM1P	2.69e-03	20	114	2	EFO_0005843
Disease	Prostatic Neoplasms	ERBB2 FBLN5 PDE4D PPARA TMEFF2 BRCA1 LRP2 SENP6	2.74e-03	616	114	8	C0033578
Disease	Malignant neoplasm of prostate	ERBB2 FBLN5 PDE4D PPARA TMEFF2 BRCA1 LRP2 SENP6	2.74e-03	616	114	8	C0376358
Disease	susceptibility to mumps measurement	PDE4D NRXN3 CCL19	3.10e-03	75	114	3	EFO_0008404
Disease	Liver Cirrhosis, Experimental	ATRN METRNL DOCK10 ITGB1 ITGB6 KANK1 ABCG8 KNG1 LRRFIP1	3.15e-03	774	114	9	C0023893
Disease	urinary bladder cancer (is_implicated_in)	ERBB2 TMEFF2 BRCA1	3.22e-03	76	114	3	DOID:11054 (is_implicated_in)
Disease	atrial fibrillation	AKAP6 KDM3A SANBR KLHL38 SYNE2 PAPPA	3.24e-03	371	114	6	EFO_0000275
Disease	clinical and behavioural ideal cardiovascular health	LDLR ABCG8	3.55e-03	23	114	2	EFO_0007654
Disease	Sensorineural Hearing Loss (disorder)	DMXL2 LRP2	3.55e-03	23	114	2	C0018784
Disease	body surface area	LRRC66 CHCHD7 PPARA SHTN1 NRXN3 FBN2 PAPPA LTBP3	3.55e-03	643	114	8	EFO_0022196
Disease	Dyslipidemias	PPARA LDLR	3.86e-03	24	114	2	C0242339
Disease	stomach carcinoma (is_marker_for)	ERBB2 BRCA1	3.86e-03	24	114	2	DOID:5517 (is_marker_for)
Disease	Dyslipoproteinemias	PPARA LDLR	3.86e-03	24	114	2	C0598784
Disease	temperament and character inventory	TG FBN2	3.86e-03	24	114	2	EFO_0004825

Protein segments in the cluster

Peptide	Gene	Start	Entry
GESSEDCQSLTRTVC	ERBB2	206	P04626
STAESEGATICTCES	EPHA1	301	P21709
CLSESDASTRCLDEN	CHCHD7	16	Q9BUK0
CDVRCQSITDAEATT	ASB10	256	Q8WXI3
TTPTETCDDINECAT	ADGRE5	56	P48960
ENCSPASSESSLDIC	ARHGEF33	641	A8MVX0
DTCVESSVTPLDTNC	ABCG8	371	Q9H221
VEVEDTTLNRCSCSF	BOLA2	21	Q9H3K6
QSSQTVSEDGDSLCC	ANKRD36B	771	Q8N2N9
DCLLGEQICETTTSS	DMXL2	276	Q8TDJ6
SLSSSSEAVTRAECC	FBN3	2311	Q75N90
ELQEDTHSCQAECSS	C1R	181	P00736
AACESACSEAESTAA	DLGAP4	481	Q9Y2H0
VAEVDCSSTNTCALS	RAB3IL1	291	Q8TBN0
CQACDVLVPSSDSTS	INTS8	306	Q75QN2
DCSLDTSTCEASNGQ	ITGB1	591	P05556
DCALCQETLSSSELA	ZFYVE28	786	Q9HCC9
CLCNEDLESRVSSES	LTN1	751	O94822
TLSDVFCCNESEAEI	RBKS	191	Q9H477
VSQSCEDSCGDSVLA	ARHGEF28	1296	Q8N1W1
QSSQTVSEDGDSLCC	ANKRD36C	1196	Q5JPF3
QEETESLNASIGCCS	DSG2	801	Q14126
SDLECADSSCNESVT	HECW2	636	Q9P2P5
DEAEEVSLISCDTCS	DNAJC24	126	Q6P3W2
TTDCSLTLDCSEGTD	FHDC1	776	Q9C0D6
QTDQTSSNCSCATSE	PASK	751	Q96RG2
SGSLCEIEINECSSE	EYS	921	Q5T1H1
SCNDLSTSSCDSQSE	KCTD16	306	Q68DU8
VSQCCEASSSDITEK	KIF11	851	P52732
SGTNDAEDCCLSVTQ	CCL19	21	Q99731
KISNSSDTVECECSE	ATRN	261	O75882
DDDDTSVCLGTRQCS	ERVMER34-1	171	Q9H9K5
RNNEECVTASTDGTC	CFAP52	471	Q8N1V2
CTTSTDSCVSEDGVL	ITGB6	576	P18564
SKARACSETEESNTC	MLH3	1026	Q9UHC1
CSETEESNTCCSDWQ	MLH3	1031	Q9UHC1
NASTDVAECDLVCTF	PIK3C2A	1516	O00443
VEEDTSCSDSKTLCT	PDE4D	756	Q08499
SCSDSKTLCTQDSES	PDE4D	761	Q08499
SSAECSSDDEDFVEC	NRXN3	1316	Q9Y4C0
TETATLIESCTNTCL	KANK1	686	Q14678
DFHSCTVTALTDCQE	NRN1	71	Q9NPD7
GSDERQDCSQSTCSS	LRP2	96	P98164
CSDTEVLLAVCTSDF	METRNL	191	Q641Q3
ECATSCLDHNSESII	PAPPA	1501	Q13219
LTDSSECLTDDCSII	RALGAPA2	901	Q2PPJ7
LCTEDEASSCATAQR	FAAP100	851	Q0VG06
CCETSIRQDSDSSVS	HIPK3	836	Q9H422
EDSLEECAITCSNSH	NBPF1	201	Q3BBV0
PEDSLEECAITCSNS	NBPF1	471	Q3BBV0
TPSDTCCELESDCDS	LRRC66	691	Q68CR7
SVCDSRQDCSDESDE	MALRD1	451	Q5VYJ5
PEDSLEECAITCSNS	NBPF3	256	Q9H094
CTELQIDSCSSSEEI	BRCA1	636	P38398
CSASLFSSQCSELED	BRCA1	1291	P38398
CALISTSIAEECEAS	BOD1L1	2216	Q8NFC6
QSECRTLTQESCDVS	COG6	231	Q9Y2V7
EDSDLHCSSIQCSTD	FRG2	6	Q64ET8
ESSVKVDNESCCSRS	KDM3A	486	Q9Y4C1
SVTCECTPEETDSSE	DOCK10	316	Q96BY6
STGTLTIQVCSCDDD	CDH20	586	Q9HBT6
RACSDSEESSEVDCV	FRMPD1	521	Q5SYB0
DKEFTRATCTDSCTS	FRMPD2	1186	Q68DX3
SCSSENQECQTAAST	C5orf22	221	Q49AR2
ESDCSQTVSPDTLCS	FAM131A	241	Q6UXB0
TDECSRTSISNCESA	ATF7IP2	251	Q5U623
EDSSEEDSDECRCVS	LTBP3	1211	Q9NS15
CTQITATECDFTAAS	IFNGR2	86	P38484
TTCSKESNEELTESC	KNG1	326	P01042
ESNQCVDVDECATDS	FBLN5	121	Q9UBX5
TTDISGTSCIDLDEC	FBN2	2481	P35556
TSECQCVEENTLECS	EGFEM1P	66	Q0D2K5
DCASESACSSDSLDE	PWWP2B	416	Q6NUJ5
VSDCDTSSICEDSFD	SCARA5	11	Q6ZMJ2
ESTSICEEVCILSAS	C2CD5	416	Q86YS7
RCDSESKVCSSEDSE	C4orf51	171	C9J302
AEQCCEETASSISLH	C9	251	P02748
QDISDACEAESTERC	LRRFIP1	736	Q32MZ4
CQCTSVETVTELTEF	PPARA	276	Q07869
SCSVEDVQNFLSDCT	HNRNPF	21	P52597
TNADSDISVEICNVC	SLITRK4	16	Q8IW52
ISCEEATCSDTSESI	URI1	441	O94763
NCDSEEDTTTLCLQS	SOCS5	321	O75159
ESSCCQSSEDEVEIL	SYT17	36	Q9BSW7
ACANETECDSIQQTT	SYNE2	6096	Q8WXH0
SGETSQKETSTCDIC	TMEFF2	151	Q9UIK5
EDSLEECAITCSNSH	NBPF8	166	Q3BBV2
PEDSLEECAITCSNS	NBPF8	436	Q3BBV2
EDSLEECAITCSNSH	NBPF9	201	P0DPF3
EDSLEECAITCSNSH	NBPF10	201	Q6P3W6
EDSLEECAITCSNSH	NBPF11	201	Q86T75
PEDSLEECAITCSNS	NBPF11	471	Q86T75
EDSLEECAITCSNSH	NBPF12	201	Q5TAG4
PEDSLEECAITCSNS	NBPF12	471	Q5TAG4
PEDSLEECAITCSNS	NBPF14	131	Q5TI25
EDSLEECAITCSNSH	NBPF15	201	Q8N660
PEDSLEECAITCSNS	NBPF26	131	B4DH59
SSAECSSDDEDFVEC	NRXN3	311	Q9HDB5
SEDGCSTEITCETFN	ORC5	86	O43913
DRSGCVQTSEEECSS	RHBDF1	506	Q96CC6
TDTDGAAETCVSVQC	SHTN1	126	A0MZ66
LTTASCSDSTADQAC	KIF25	206	Q9UIL4
APCCSVSSESIQDAD	SWT1	326	Q5T5J6
CRSDSEDECSTQEAD	PI4KAP2	291	A4QPH2
SIASTRNCSSESENC	SANBR	116	Q6NSI8
SCTSACTDDEDDSDL	AKAP6	1741	Q13023
TEETQETALTLACCG	ANKHD1	501	Q8IWZ3
EECITCTETCETLTL	TECTA	991	O75443
NSLISTVIDSCNCSD	TULP4	501	Q9NRJ4
TVIDSCNCSDSSDIE	TULP4	506	Q9NRJ4
EVCSTSVDGSECVTL	USP4	566	Q13107
HSNATCTEDEAVTTC	UMOD	36	P07911
CSSETDLESSCEETE	RLF	1251	Q13129
ERSSSVACSAALDCD	RP1L1	1501	Q8IWN7
EISDCASCASNQSLT	SPIDR	151	Q14159
SCSICSESFHTVEEL	ZNF521	311	Q96K83
DHSATVTIDDCTNCI	RP2	76	O75695
SSCSETSFDCDVSLE	ZDBF2	576	Q9HCK1
CSTVEDSCISSSASE	SENP6	796	Q9GZR1
DVTSNATTNTCDSCT	USF3	1111	Q68DE3
ATTNTCDSCTFVEQT	USF3	1116	Q68DE3
STSVFLEDCSDCVLA	TBCC	241	Q15814
ESSEEPICVSDCSES	ZNF518A	1216	Q6AHZ1
KNEDVCSCSTDTSEV	NUP153	61	P49790
DTVCQICESSGDSLI	NSD3	701	Q9BZ95
EECQGTDLDTRNCTS	UNC5A	276	Q6ZN44
CSASSCLDTSNDPDD	SNAPC4	1436	Q5SXM2
FCTKTSDTVCDSCED	TNFRSF1B	66	P20333
DCTEDEACSFFTVST	TG	1606	P01266
KSQSDVDFQSCESCS	USP33	311	Q8TEY7
LTTDCNIEDSASFDC	KLHL38	531	Q2WGJ6
ECQDGSDESQETCLS	LDLR	51	P01130
SDESQETCLSVTCKS	LDLR	56	P01130
DAEAICSLCTSLSTQ	MYO5B	1756	Q9ULV0