Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	HIC1 ZNF48 FOXO6 TFAP2E PTF1A GATA1 ZKSCAN7 HOXA3 ZBTB46 ZBTB39 GZF1 NFATC1 ZIC5 GLI1 ZNF764 ZNF746 YLPM1 FOXI2 DMRTA2 PCBP1 FOXE3	5.47e-06	1412	100	21	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF48 FOXO6 TFAP2E PTF1A GATA1 ZKSCAN7 KDM6B HOXA3 ZBTB39 AGO1 GZF1 NFATC1 ZIC5 GLI1 ZNF764 ZNF746 FOXI2 DMRTA2 FOXE3	1.14e-05	1244	100	19	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF48 FOXO6 TFAP2E PTF1A GATA1 ZKSCAN7 KDM6B HOXA3 ZBTB39 AGO1 GZF1 NFATC1 ZIC5 GLI1 ZNF764 ZNF746 FOXI2 DMRTA2 FOXE3	1.55e-05	1271	100	19	GO:0000987
GeneOntologyMolecularFunction	transferrin receptor activity	TFR2 TFRC	2.48e-05	2	100	2	GO:0004998
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF48 FOXO6 TFAP2E PTF1A GATA1 ZKSCAN7 KDM6B HOXA3 ZBTB39 AGO1 GZF1 NFATC1 ZIC5 GLI1 ZNF764 ZNF746 FOXI2 DMRTA2 FOXE3	1.01e-04	1459	100	19	GO:0000977
GeneOntologyMolecularFunction	histone H3 demethylase activity	RIOX1 KDM6B KDM4E	3.65e-04	28	100	3	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	RIOX1 KDM6B KDM4E	4.95e-04	31	100	3	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	RIOX1 KDM6B KDM4E	5.44e-04	32	100	3	GO:0140457
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	HIC1 ZBTB46 ZBTB39 GZF1 NFATC1 ZNF746 YLPM1	1.14e-03	320	100	7	GO:0001227
GeneOntologyMolecularFunction	chromatin binding	PTF1A GATA1 KDM6B KDM4E HDAC7 NFATC1 GLI1 SETD7 NKAP CTNNB1 AJUBA	1.18e-03	739	100	11	GO:0003682
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	HIC1 ZBTB46 ZBTB39 GZF1 NFATC1 ZNF746 YLPM1	1.27e-03	326	100	7	GO:0001217
GeneOntologyMolecularFunction	demethylase activity	RIOX1 KDM6B KDM4E	1.39e-03	44	100	3	GO:0032451
GeneOntologyMolecularFunction	alpha-catenin binding	CTNNB1 AJUBA	1.59e-03	12	100	2	GO:0045294
GeneOntologyCellularComponent	chromatin	HIC1 FOXO6 TFAP2E PTF1A BICRA CECR2 GATA1 KDM4E HNRNPL HOXA3 ZBTB46 NFATC1 ZMIZ2 FOXI2 DMRTA2 CTNNB1 SLX4 DNMT3L FOXE3	6.66e-05	1480	100	19	GO:0000785
Domain	BTB	HIC1 ZBTB46 ZBTB39 GZF1 KLHL42 SLX4	1.77e-04	160	96	6	PS50097
Domain	BTB/POZ_dom	HIC1 ZBTB46 ZBTB39 GZF1 KLHL42 SLX4	3.86e-04	185	96	6	IPR000210
Domain	TFR_dimer	TFR2 TFRC	3.87e-04	6	96	2	PF04253
Domain	-	TFR2 TFRC	3.87e-04	6	96	2	1.20.930.40
Domain	SKP1/BTB/POZ	HIC1 ZBTB46 ZBTB39 GZF1 KLHL42 SLX4	4.32e-04	189	96	6	IPR011333
Domain	TFR-like_dimer_dom	TFR2 TFRC	5.40e-04	7	96	2	IPR007365
Domain	BTB	HIC1 ZBTB46 ZBTB39 GZF1 SLX4	5.77e-04	131	96	5	PF00651
Domain	JMJC	RIOX1 KDM6B KDM4E	5.86e-04	32	96	3	PS51184
Domain	JmjC_dom	RIOX1 KDM6B KDM4E	5.86e-04	32	96	3	IPR003347
Domain	JmjC	RIOX1 KDM6B KDM4E	6.42e-04	33	96	3	SM00558
Domain	-	ZNF703 HIC1 ZNF48 ZKSCAN7 ZBTB46 ZBTB39 GZF1 ZIC5 GLI1 ZNF764 ZNF746	7.21e-04	679	96	11	3.30.160.60
Domain	Znf_C2H2	ZNF703 HIC1 SORBS2 ZNF48 ZKSCAN7 ZBTB46 ZBTB39 GZF1 ZIC5 GLI1 ZNF764 ZNF746	8.51e-04	805	96	12	IPR007087
Domain	Znf_C2H2/integrase_DNA-bd	ZNF703 HIC1 ZNF48 ZKSCAN7 ZBTB46 ZBTB39 GZF1 ZIC5 GLI1 ZNF764 ZNF746	8.62e-04	694	96	11	IPR013087
Domain	VWF_dom	DGCR2 MUC5AC OTOG	1.31e-03	42	96	3	IPR001007
Domain	TIL	MUC5AC OTOG	1.67e-03	12	96	2	PF01826
Domain	Peptidase_M28	TFR2 TFRC	1.67e-03	12	96	2	IPR007484
Domain	C8	MUC5AC OTOG	1.67e-03	12	96	2	PF08742
Domain	Peptidase_M28	TFR2 TFRC	1.67e-03	12	96	2	PF04389
Domain	TF_fork_head_CS_1	FOXO6 FOXI2 FOXE3	1.81e-03	47	96	3	IPR018122
Domain	Unchr_dom_Cys-rich	MUC5AC OTOG	1.97e-03	13	96	2	IPR014853
Domain	C8	MUC5AC OTOG	1.97e-03	13	96	2	SM00832
Domain	FH	FOXO6 FOXI2 FOXE3	2.04e-03	49	96	3	SM00339
Domain	FORK_HEAD_1	FOXO6 FOXI2 FOXE3	2.04e-03	49	96	3	PS00657
Domain	FORK_HEAD_2	FOXO6 FOXI2 FOXE3	2.04e-03	49	96	3	PS00658
Domain	Fork_head_dom	FOXO6 FOXI2 FOXE3	2.04e-03	49	96	3	IPR001766
Domain	FORK_HEAD_3	FOXO6 FOXI2 FOXE3	2.04e-03	49	96	3	PS50039
Domain	Forkhead	FOXO6 FOXI2 FOXE3	2.04e-03	49	96	3	PF00250
Domain	ZINC_FINGER_C2H2_2	ZNF703 HIC1 ZNF48 ZKSCAN7 ZBTB46 ZBTB39 GZF1 ZIC5 GLI1 ZNF764 ZNF746	2.08e-03	775	96	11	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF703 HIC1 ZNF48 ZKSCAN7 ZBTB46 ZBTB39 GZF1 ZIC5 GLI1 ZNF764 ZNF746	2.12e-03	777	96	11	PS00028
Domain	TIL_dom	MUC5AC OTOG	2.29e-03	14	96	2	IPR002919
Domain	BTB	HIC1 ZBTB46 ZBTB39 GZF1 SLX4	2.37e-03	180	96	5	SM00225
Domain	Znf_C2H2-like	ZNF703 HIC1 ZNF48 ZKSCAN7 ZBTB46 ZBTB39 GZF1 ZIC5 GLI1 ZNF764 ZNF746	2.56e-03	796	96	11	IPR015880
Domain	Pept_M10A_Zn_BS	MMP27 MMP16	2.63e-03	15	96	2	IPR021158
Domain	ZnF_C2H2	ZNF703 HIC1 ZNF48 ZKSCAN7 ZBTB46 ZBTB39 GZF1 ZIC5 GLI1 ZNF764 ZNF746	2.87e-03	808	96	11	SM00355
Domain	zf-C2H2	HIC1 ZNF48 ZKSCAN7 ZBTB46 ZBTB39 GZF1 ZIC5 GLI1 ZNF764 ZNF746	2.96e-03	693	96	10	PF00096
Domain	VWD	MUC5AC OTOG	2.99e-03	16	96	2	SM00216
Domain	VWF_type-D	MUC5AC OTOG	2.99e-03	16	96	2	IPR001846
Domain	VWFD	MUC5AC OTOG	2.99e-03	16	96	2	PS51233
Domain	AT_hook	CECR2 PRR12	2.99e-03	16	96	2	PF02178
Domain	VWD	MUC5AC OTOG	2.99e-03	16	96	2	PF00094
Domain	Hemopexin_CS	MMP27 MMP16	3.38e-03	17	96	2	IPR018486
Domain	Pept_M10A_stromelysin-type	MMP27 MMP16	3.79e-03	18	96	2	IPR016293
Domain	VWC_out	MUC5AC OTOG	4.22e-03	19	96	2	SM00215
Domain	PA	TFR2 TFRC	4.22e-03	19	96	2	PF02225
Domain	PA_domain	TFR2 TFRC	4.22e-03	19	96	2	IPR003137
Domain	PG_binding_1	MMP27 MMP16	4.68e-03	20	96	2	PF01471
Domain	Peptidoglycan-bd-like	MMP27 MMP16	4.68e-03	20	96	2	IPR002477
Domain	CT	MUC5AC OTOG	5.65e-03	22	96	2	SM00041
Domain	Hemopexin-like_dom	MMP27 MMP16	6.17e-03	23	96	2	IPR000585
Domain	Hemopexin-like_repeat	MMP27 MMP16	6.17e-03	23	96	2	IPR018487
Domain	M10A_MMP	MMP27 MMP16	6.17e-03	23	96	2	IPR033739
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DGCR2 ZNF48 SHISA5 BICRA IRAK1 LAMA5 C15orf39 ADGRL1 ATG2A KDM6B ZDHHC8 CNTROB HDAC7 PRR12 EHBP1L1 NFATC1 GLI1 ZMIZ2 SEC16A	3.45e-10	1105	100	19	35748872
Pubmed	Interaction network of human early embryonic transcription factors.	ZNF703 BICRA C15orf39 TFRC PRR12 ZMIZ2 ZNF746 SEC16A CTNNB1 SLX4	7.47e-08	351	100	10	38297188
Pubmed	Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion.	TFR2 TFRC CSF1R	8.01e-07	7	100	3	6641714
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	ZNF703 DSG2 WDR33 C15orf39 PRR12 YLPM1 SEC16A	9.44e-07	180	100	7	35198878
Pubmed	Embryonic attenuated Wnt/β-catenin signaling defines niche location and long-term stem cell fate in hair follicle.	NFATC1 GLI1 CTNNB1	1.91e-06	9	100	3	26653852
Pubmed	Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity.	PTF1A GLI1 CTNNB1 MUC5AC	3.53e-06	36	100	4	27736991
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	MAP1A BICRA ATG2A LATS1 ZMIZ2 YLPM1 RNF38 IGSF9B AJUBA	4.38e-06	430	100	9	35044719
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	ZNF703 WDR33 BICRA C15orf39 PRR12 ZMIZ2	5.36e-06	152	100	6	38360978
Pubmed	Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid.	NFATC1 GLI1	8.18e-06	2	100	2	26601952
Pubmed	Engagement of transferrin receptor by polymeric IgA1: evidence for a positive feedback loop involving increased receptor expression and mesangial cell proliferation in IgA nephropathy.	TFR2 TFRC	8.18e-06	2	100	2	15987753
Pubmed	Fractions of Shen-Sui-Tong-Zhi Formula Enhance Osteogenesis Via Activation of β-Catenin Signaling in Growth Plate Chondrocytes.	GLI1 CTNNB1	8.18e-06	2	100	2	34630086
Pubmed	A novel transferrin receptor-targeted hybrid peptide disintegrates cancer cell membrane to induce rapid killing of cancer cells.	TFR2 TFRC	8.18e-06	2	100	2	21849092
Pubmed	Bushenhuoxue formula promotes osteogenic differentiation of growth plate chondrocytes through β-catenin-dependent manner during osteoporosis.	GLI1 CTNNB1	8.18e-06	2	100	2	32334373
Pubmed	Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation.	HDAC7 CTNNB1	8.18e-06	2	100	2	21836063
Pubmed	Fibroblast-Specific β-Catenin Signaling Dictates the Outcome of AKI.	GLI1 CTNNB1	8.18e-06	2	100	2	29343518
Pubmed	Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells.	KDM6B CTNNB1	8.18e-06	2	100	2	23856522
Pubmed	Immunohistochemical demonstration of transferrin receptor 1 and 2 in human hepatocellular carcinoma tissue.	TFR2 TFRC	8.18e-06	2	100	2	24901155
Pubmed	Histone deacetylase 7 (Hdac7) suppresses chondrocyte proliferation and β-catenin activity during endochondral ossification.	HDAC7 CTNNB1	8.18e-06	2	100	2	25389289
Pubmed	Heterotypic interactions between transferrin receptor and transferrin receptor 2.	TFR2 TFRC	8.18e-06	2	100	2	12406888
Pubmed	Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1.	KDM6B NFATC1	8.18e-06	2	100	2	21735477
Pubmed	The transcription factor GATA1 and the histone methyltransferase SET7 interact to promote VEGF-mediated angiogenesis and tumor growth and predict clinical outcome of breast cancer.	GATA1 SETD7	8.18e-06	2	100	2	26848522
Pubmed	Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through beta-catenin.	GLI1 CTNNB1	8.18e-06	2	100	2	19329935
Pubmed	Role of TfR2-Y250X and TfR1- rs3817672 Single Nucleotide Polymorphism on Pathophysiology of Iron Deficiency Anemia.	TFR2 TFRC	8.18e-06	2	100	2	31793267
Pubmed	β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma.	GLI1 CTNNB1	8.18e-06	2	100	2	25645196
Pubmed	Transferrin facilitates the formation of DNA double-strand breaks via transferrin receptor 1: the possible involvement of transferrin in carcinogenesis of high-grade serous ovarian cancer.	TFR2 TFRC	8.18e-06	2	100	2	26549031
Pubmed	SET7/9 inhibits oncogenic activities through regulation of Gli-1 expression in breast cancer.	GLI1 SETD7	8.18e-06	2	100	2	26779630
Pubmed	Constitutive Activation of β-Catenin in Conventional Dendritic Cells Increases the Insulin Reserve to Ameliorate the Development of Type 2 Diabetes in Mice.	ZBTB46 CTNNB1	8.18e-06	2	100	2	31048369
Pubmed	Gli regulates MUC5AC transcription in human gastrointestinal cells.	GLI1 MUC5AC	8.18e-06	2	100	2	25166306
Pubmed	SET7/9 regulates cancer cell proliferation by influencing β-catenin stability.	SETD7 CTNNB1	8.18e-06	2	100	2	26116705
Pubmed	FoxO6 regulates Hippo signaling and growth of the craniofacial complex.	FOXO6 LATS1 CTNNB1	8.20e-06	14	100	3	30286078
Pubmed	GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling.	PTF1A GLI1 MUC5AC	1.26e-05	16	100	3	26932670
Pubmed	Human transcription factor protein interaction networks.	ZNF703 WDR33 BICRA GATA1 IRAK1 C15orf39 HNRNPL TFRC PRR12 AGO1 ZMIZ2 ZNF746 YLPM1 SEC16A SLX4	1.42e-05	1429	100	15	35140242
Pubmed	Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation.	LAMA5 NFATC1 CTNNB1	1.52e-05	17	100	3	22306086
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	ZNF703 BICRA CECR2 IRAK1 C15orf39 PRR12 ZMIZ2 SEC16A	2.04e-05	398	100	8	35016035
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	ZNF703 WDR33 BICRA HNRNPL YLPM1 SEC16A SETD7 PCBP1	2.08e-05	399	100	8	35987950
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TRIM46 SORBS2 CAMSAP3 ITIH4 AGO1 YLPM1 SEC16A DCHS1 CTNNB1 PCBP1 FERMT3 BEGAIN	2.13e-05	963	100	12	28671696
Pubmed	Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway.	GLI1 CTNNB1 MUC5AC	2.16e-05	19	100	3	27122169
Pubmed	Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA.	GLI1 CTNNB1	2.45e-05	3	100	2	19887615
Pubmed	Dynein is required for receptor sorting and the morphogenesis of early endosomes.	TFRC DNAH12	2.45e-05	3	100	2	17173037
Pubmed	Iron-loaded transferrin potentiates erythropoietin effects on erythroblast proliferation and survival: a novel role through transferrin receptors.	TFR2 TFRC	2.45e-05	3	100	2	34077792
Pubmed	Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin.	CTNNB1 AJUBA	2.45e-05	3	100	2	17621269
Pubmed	GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin.	GLI1 MUC5AC	2.45e-05	3	100	2	20972463
Pubmed	Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase.	DOHH PCBP1	2.45e-05	3	100	2	24843120
Pubmed	Zfp703 Is a Wnt/β-Catenin Feedback Suppressor Targeting the β-Catenin/Tcf1 Complex.	ZNF703 CTNNB1	2.45e-05	3	100	2	27090637
Pubmed	β-Catenin/Tcf7l2-dependent transcriptional regulation of GLUT1 gene expression by Zic family proteins in colon cancer.	ZIC5 CTNNB1	2.45e-05	3	100	2	31392276
Pubmed	The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells.	TFR2 TFRC	2.45e-05	3	100	2	19828835
Pubmed	HDAC7 inhibits osteoclastogenesis by reversing RANKL-triggered β-catenin switch.	HDAC7 CTNNB1	2.45e-05	3	100	2	23204328
Pubmed	Transferrin and transferrin receptors update.	TFR2 TFRC	2.45e-05	3	100	2	29969719
Pubmed	Mechanical loading regulates NFATc1 and beta-catenin signaling through a GSK3beta control node.	NFATC1 CTNNB1	2.45e-05	3	100	2	19840939
Pubmed	Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing Mechanisms.	TFR2 TFRC	2.45e-05	3	100	2	29388418
Pubmed	Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation.	PTF1A GLI1	2.45e-05	3	100	2	23482563
Pubmed	HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions.	TFR2 TFRC	2.45e-05	3	100	2	17956864
Pubmed	Enhancement of GLI1-transcriptional activity by beta-catenin in human cancer cells.	GLI1 CTNNB1	2.45e-05	3	100	2	16786128
Pubmed	GLI1, CTNNB1 and NOTCH1 protein expression in a thymic epithelial malignancy tissue microarray.	GLI1 CTNNB1	2.45e-05	3	100	2	25667444
Pubmed	Complement C1q essential for aeroallergen sensitization via CSF1R+ conventional dendritic cells type 2.	ZBTB46 CSF1R	2.45e-05	3	100	2	37562753
Pubmed	Stoichiometries of transferrin receptors 1 and 2 in human liver.	TFR2 TFRC	2.45e-05	3	100	2	19819738
Pubmed	Aluminum exposure affects transferrin-dependent and -independent iron uptake by K562 cells.	TFR2 TFRC	2.45e-05	3	100	2	16085060
Pubmed	Absence of binding between the human transferrin receptor and the transferrin complex of biological toxic trace element, aluminum, because of an incomplete open/closed form of the complex.	TFR2 TFRC	2.45e-05	3	100	2	19859668
Pubmed	Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets.	ZBTB46 CTNNB1	2.45e-05	3	100	2	29514067
Pubmed	Stabilization of beta-catenin induces pancreas tumor formation.	PTF1A CTNNB1	2.45e-05	3	100	2	18725219
Pubmed	Notch signaling is required for exocrine regeneration after acute pancreatitis.	PTF1A CTNNB1	2.45e-05	3	100	2	18242220
Pubmed	Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.	TFR2 TFRC	2.45e-05	3	100	2	16893896
Pubmed	ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.	HIC1 ZBTB46 ZBTB39 GZF1	3.36e-05	63	100	4	34351428
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	TRIM46 SORBS2 CAMSAP3 ADGRL1 SLC32A1 CTNNB1 PCBP1 BEGAIN	3.53e-05	430	100	8	32581705
Pubmed	Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular program.	HOXA3 GLI1 CTNNB1	3.92e-05	23	100	3	19906864
Pubmed	Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.	DSG2 TFRC DCHS1 CTNNB1	4.29e-05	67	100	4	21875946
Pubmed	Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production.	TFRC PCBP1	4.89e-05	4	100	2	29958803
Pubmed	Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice.	PTF1A CTNNB1	4.89e-05	4	100	2	20071774
Pubmed	Canonical wnt signaling is required for pancreatic carcinogenesis.	PTF1A CTNNB1	4.89e-05	4	100	2	23761328
Pubmed	Inactivation of the transcription factor GLI1 accelerates pancreatic cancer progression.	PTF1A GLI1	4.89e-05	4	100	2	24737325
Pubmed	Heme deficiency in erythroid lineage causes differentiation arrest and cytoplasmic iron overload.	GATA1 TFRC	4.89e-05	4	100	2	10562540
Pubmed	Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE.	TFR2 TFRC	4.89e-05	4	100	2	11027676
Pubmed	Wnt signaling regulates intermediate precursor production in the postnatal dentate gyrus by regulating CXCR4 expression.	GLI1 CTNNB1	4.89e-05	4	100	2	23257686
Pubmed	Influence of data sampling methods on the representation of neural spiking activity in vivo.	PTF1A SLC32A1	4.89e-05	4	100	2	36388953
Pubmed	Lhx6 regulates canonical Wnt signaling to control the fate of mesenchymal progenitor cells during mouse molar root patterning.	GLI1 CTNNB1	4.89e-05	4	100	2	33596195
Pubmed	Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.	DSG2 CTNNB1	4.89e-05	4	100	2	8858175
Pubmed	RIOX1-demethylated cGAS regulates ionizing radiation-elicited DNA repair.	RIOX1 SETD7	4.89e-05	4	100	2	35210392
Pubmed	ZNF326 promotes malignant phenotype of glioma by up-regulating HDAC7 expression and activating Wnt pathway.	HDAC7 CTNNB1	4.89e-05	4	100	2	30691485
Pubmed	Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability.	HDAC7 CTNNB1	4.89e-05	4	100	2	36163081
Pubmed	Activation of β-catenin in mesenchymal progenitors leads to muscle mass loss.	HIC1 CTNNB1	4.89e-05	4	100	2	36898377
Pubmed	Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor.	TFR2 TFRC	4.89e-05	4	100	2	10638746
Pubmed	Investigation of genetic variants of genes of the hemochromatosis pathway and their role in breast cancer.	TFR2 TFRC	4.89e-05	4	100	2	15894659
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	RPL10L ZNF703 MAP1A WDR33 C15orf39 NFATC1 SEC16A CTNNB1 SLX4	5.16e-05	588	100	9	38580884
Pubmed	Hippo signaling regulates pancreas development through inactivation of Yap.	PTF1A LATS1 CTNNB1	5.72e-05	26	100	3	23071096
Pubmed	Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development.	LATS1 DCHS1 CTNNB1	5.72e-05	26	100	3	21303848
Pubmed	22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development.	DGCR2 ZDHHC8 GLI1	7.98e-05	29	100	3	23077214
Pubmed	Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice.	PTF1A GLI1	8.14e-05	5	100	2	22232209
Pubmed	GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.	PTF1A GLI1	8.14e-05	5	100	2	19136624
Pubmed	Altered compensatory cytokine signaling underlies the discrepancy between Flt3-/- and Flt3l-/- mice.	ZBTB46 CSF1R	8.14e-05	5	100	2	29572360
Pubmed	Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis.	GLI1 CTNNB1	8.14e-05	5	100	2	36323713
Pubmed	Gli1 identifies osteogenic progenitors for bone formation and fracture repair.	GLI1 CTNNB1	8.14e-05	5	100	2	29230039
Pubmed	Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation.	GZF1 NFATC1	8.14e-05	5	100	2	17674968
Pubmed	Dendritic Inhibition by Shh Signaling-Dependent Stellate Cell Pool Is Critical for Motor Learning.	PTF1A GLI1	8.14e-05	5	100	2	35589396
Pubmed	lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization.	HNRNPL SETD7	8.14e-05	5	100	2	34252487
Pubmed	The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis.	PTF1A GLI1	8.14e-05	5	100	2	22493246
Pubmed	HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies.	HIC1 CTNNB1	8.14e-05	5	100	2	16724116
Pubmed	Identification of an atypical monocyte and committed progenitor involved in fibrosis.	GATA1 KDM6B	8.14e-05	5	100	2	28002407
Pubmed	HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron.	TFR2 TFRC	8.14e-05	5	100	2	18353247
Pubmed	Distinct bulge stem cell populations maintain the pilosebaceous unit in a β-catenin-dependent manner.	GLI1 CTNNB1	8.14e-05	5	100	2	36619975
Pubmed	Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.	PTF1A NFATC1	8.14e-05	5	100	2	24694735
Interaction	EGR2 interactions	BICRA C15orf39 PRR12 NFATC1 ZMIZ2 ZNF746 SEC16A CTNNB1 DNMT3L	1.52e-07	171	98	9	int:EGR2
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	HIC1 ZBTB46 ZBTB39 GZF1 SLX4	1.29e-04	134	66	5	861
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	HIC1 ZNF48 ZKSCAN7 ZBTB46 ZBTB39 GZF1 ZIC5 GLI1 ZNF764 ZNF746	2.58e-04	718	66	10	28
GeneFamily	Forkhead boxes	FOXO6 FOXI2 FOXE3	5.17e-04	43	66	3	508
GeneFamily	Cadherin related	PCDH15 DCHS1	1.72e-03	17	66	2	24
GeneFamily	Ring finger proteins	TRIM46 TRIM75 TRIM71 RNF157 RNF38	3.29e-03	275	66	5	58
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP27 MMP16	3.44e-03	24	66	2	891
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM6B KDM4E	3.44e-03	24	66	2	485
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM46 TRIM75 TRIM71	5.06e-03	95	66	3	59
Disease	short-term memory	SORBS2 DNAH12 NFATC1 PCDH15	1.52e-04	83	95	4	EFO_0004335
Disease	lung cancer (is_marker_for)	GATA1 CSF1R CTNNB1	2.72e-04	39	95	3	DOID:1324 (is_marker_for)
Disease	acute myeloid leukemia (is_marker_for)	GATA1 TFR2 FERMT3	5.35e-04	49	95	3	DOID:9119 (is_marker_for)
Disease	Cooley's anemia	TFR2 TFRC	6.63e-04	12	95	2	C0002875
Disease	Thalassemia Minor	TFR2 TFRC	6.63e-04	12	95	2	C0085578
Disease	Thalassemia Intermedia	TFR2 TFRC	6.63e-04	12	95	2	C0271979
Disease	beta Thalassemia	TFR2 TFRC	6.63e-04	12	95	2	C0005283
Disease	renal cell carcinoma (is_marker_for)	KDM6B TFRC CSF1R CTNNB1	7.93e-04	128	95	4	DOID:4450 (is_marker_for)
Disease	iron biomarker measurement, transferrin saturation measurement	TFR2 TFRC	9.10e-04	14	95	2	EFO_0004461, EFO_0006333
Disease	Hemoglobin F Disease	TFR2 TFRC	1.05e-03	15	95	2	C0019025
Disease	carcinoma (implicated_via_orthology)	LATS1 CSF1R CTNNB1	1.17e-03	64	95	3	DOID:305 (implicated_via_orthology)
Disease	transferrin saturation measurement	TFR2 TFRC	1.20e-03	16	95	2	EFO_0006333
Disease	MYELODYSPLASTIC SYNDROME	GATA1 CSF1R SLX4	1.33e-03	67	95	3	C3463824
Disease	sex interaction measurement, ulcerative colitis	EDEM2 TNXB	1.35e-03	17	95	2	EFO_0000729, EFO_0008343
Disease	maximum cigarettes per day measurement	NFATC1 TMC5	1.52e-03	18	95	2	EFO_0009264
Disease	colorectal cancer (is_marker_for)	GATA1 HDAC7 GLI1 CTNNB1	1.69e-03	157	95	4	DOID:9256 (is_marker_for)
Disease	serum iron measurement	TFR2 DCHS1 TMC5	2.73e-03	86	95	3	EFO_0006332
Disease	serum gamma-glutamyl transferase measurement	TRIM46 SORBS2 C16orf90 MAP1A BICRA IRAK1 ZBTB46 ZMIZ2 DMRTA2	2.75e-03	914	95	9	EFO_0004532
Disease	colon adenocarcinoma (is_implicated_in)	GATA1 CSF1R	3.17e-03	26	95	2	DOID:234 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GPFDLVYGATPPLGH	DNMT3L	236	Q9UJW3
SADPLPGYAPSEGGD	BEGAIN	506	Q9BUH8
SPGGVPSAYPELHAA	AJUBA	196	Q96IF1
PSHEGYLAAPGLEGP	ADGRL1	1446	O94910
GPHPSGLTDSLDYPG	GZF1	171	Q9H116
SPPEGYYHPLGGGRE	AGO1	181	Q9UL18
PDLGPVPHEGLGEYN	CAMSAP3	686	Q9P1Y5
DAGAYPLGAPLGLSP	DMRTA2	451	Q96SC8
TLYGSSGVPEPHPGE	CECR2	666	Q9BXF3
GGEPAAGPYLSVDPA	DOHH	136	Q9BU89
LHGIYEDGGKPPVPC	ATG2A	701	Q2TAZ0
FPHLAGDPYGGLAPL	TFAP2E	76	Q6VUC0
GLPGPPDVPDHAAYH	ITIH4	671	Q14624
DPHGLVQPGAYPLGL	QRICH2	761	Q9H0J4
VPGPLPDFGLEESGH	DSG2	1081	Q14126
YFDGPLGVLGHAFPP	MMP27	171	Q9H306
APDGGPITYHLAAEG	DCHS1	1026	Q96JQ0
GHHPGADYPVDGLPD	CTNNB1	741	P35222
GYPHATHDLEGPPLD	PCBP1	206	Q15365
HYIERGPPGPGAAAA	TRIM71	236	Q2Q1W2
PGHALHPGEPALGEA	MAP1A	966	P78559
GPGPGEPHPTYTDLT	HOXA3	411	O43365
GPPLGESVAYHSESP	LATS1	191	O95835
SEDPSPPGGHLEGYP	HIC1	406	Q14526
RGVEPNPGIPGADHY	KDM6B	411	O15054
TAHPPGYEPGDLGAV	FOXI2	21	Q6ZQN5
GAPGPDGSAPDPAHY	EDEM2	21	Q9BV94
LDALPGPYAAAAAGP	FOXO6	411	A8MYZ6
LDGSYDQLTGHPPGP	KCNIP2	16	Q9NS61
PPADHPSGYGAALDG	NFATC1	81	O95644
DEGGPLPESPVGLDY	DNAH12	171	Q6ZR08
PPAEPAGHSGQLGDL	EHBP1L1	481	Q8N3D4
HPGNPPIYGADISGS	KDM4E	126	B2RXH2
GEFPSHSGLYPGPKA	GLI1	781	P08151
DFPSPGPHGGDKETY	MUC5AC	1756	P98088
DFPSPGPHGGDKETY	MUC5AC	3966	P98088
AAGAPAPLYLGGLPE	LAMA5	3636	O15230
GPGEPAAPGAQHFLY	IRAK1	6	P51617
PSDPDYGLPPLAGHS	PTF1A	266	Q7RTS3
PPHLGYGEEGRGNIP	FKBP9	336	O95302
PPPGAHLYEELGDSS	PCDH15	1441	Q96QU1
PESPAALGPPGYLHS	RGL4	156	Q8IZJ4
ALGPPGYLHSAPGPA	RGL4	161	Q8IZJ4
GYLHSAPGPAPAPGE	RGL4	166	Q8IZJ4
GPPGTAHLYQGLGPV	GATA1	356	P15976
EPGDPLGGSAAIHLY	CSF1R	86	P07333
GALPGAKAGDPHLDY	CARD14	511	Q9BXL6
YPPLIPGDGHDSHTL	AVL9	36	Q8NBF6
GHPDAPPNIYEGGLG	C16orf90	26	A8MZG2
YGPDGFGTGLTPLHL	DGCR2	401	P98153
QPPLLGDHPAEYGGP	HNRNPL	306	P14866
TPLFLPHGLEPEAGG	HDAC7	286	Q8WUI4
GEPDSTGHRYGPESP	ENPP7	196	Q6UWV6
PEAYPPSSHNGGLGA	BICRA	1541	Q9NZM4
PPRPSPGGLHYSDED	SDK1	2086	Q7Z5N4
LYLPSTSPPHEGLDG	CNTROB	56	Q8N137
PLNYGHALLPGEGAA	NKAP	306	Q8N5F7
VDYPPGDSDIPSLGH	OTOG	851	Q6ZRI0
IPDGCGVKYVPSHGP	RPL10L	191	Q96L21
LDYGAPPHGGIALGL	DARS2	571	Q6PI48
YIGHGGDPSSEPTSP	TRIM46	66	Q7Z4K8
EGDASPLGPYLLPSG	SEZ6L	36	Q9BYH1
GEHLPVGGFTYPPSA	RNF38	316	Q9H0F5
GMLPSYGSDGHLPPV	RNF157	396	Q96PX1
LGGEVPGSHQGPDPY	TMEM205	126	Q6UW68
YALRGPEHPGSGGAP	PPP1R3E	256	Q9H7J1
GSPGAGLATPPYPHL	HDHD5	216	Q9BXW7
GPAAALGPLSPGEAY	FOXE3	291	Q13461
GYDHSPPGKSGPEAP	SETD7	336	Q8WTS6
PPAYHETLAGGAAAP	SHISA5	206	Q8N114
LHDGPPYANGDPHVG	IARS2	111	Q9NSE4
GEPYPGPAAHSQGLP	PRR12	511	Q9ULL5
AHLGTGDPYTPGFPS	TFRC	301	P02786
HYPGIGPVDESGIPT	SORBS2	71	O94875
PYGHLGPAELLEASP	RIOX1	96	Q9H6W3
AGNVYGLGPPAPESD	SLX4	251	Q8IY92
GSYSPALPLQPLGGH	C15orf39	296	Q6ZRI6
PGPLHFSGYSSVPDG	ST6GALNAC4	51	Q9H4F1
SPSHSGEPFGLPGLE	ZNF48	416	Q96MX3
AHDPAGPSLKAGGYP	ZNF703	401	Q9H7S9
PGYPHDLITLGSGIP	MMP16	421	P51512
YIPGVDPETSHGGHP	SEC16A	161	O15027
AAGSYEAPLPPGSFH	SEC16A	1386	O15027
VLPYPEPAEPGAHGG	IGSF9B	1146	Q9UPX0
DDGYHAPGAFPTPLL	TRIM75	391	A6NK02
YELSLHGVPPGGKPS	TNXB	1026	P22105
EGSLDLGHAPLGPYA	TMEM102	96	Q8N9M5
PHGPDASAEGLNPYG	FERMT3	491	Q86UX7
DGPRPRYEGHPAEGT	YLPM1	791	P49750
LPPAPHGDGSFAYES	ZMIZ2	11	Q8NF64
EPAHPLGELRGGGDY	ZBTB39	151	O15060
LSGGSAPGAHLEPPY	ZKSCAN7	171	Q9P0L1
APGAHLEPPYDPGTH	ZKSCAN7	176	Q9P0L1
LEPPYDPGTHHLPSG	ZKSCAN7	181	Q9P0L1
SEPSLDLPDYGPGGL	ZDHHC8	396	Q9ULC8
DLPDYGPGGLHAAYP	ZDHHC8	401	Q9ULC8
THPDHFGSLEPDYPG	TMC5	151	Q6UXY8
GESGPVHAYGNPPLS	TMC5	326	Q6UXY8
GDIHYQRGSGAPLPP	SLC32A1	81	Q9H598
GPEGLPYSSPDNGEA	ZNF746	396	Q6NUN9
DGYHRDEPFGGPPGS	WDR33	1286	Q9C0J8
GLYAQAGERPPHTGP	PVRIG	291	Q6DKI7
QGSLLGSPYHLGPGP	TFR2	381	Q9UP52
EGSPEALFPGDGPYL	ZBTB46	521	Q86UZ6
PGHGDLDPPVGFQLY	ZNF764	386	Q96H86
PDGSGGPALFPALHD	ZIC5	251	Q96T25
DFLGGPLAPHPYQGE	KLHL42	201	Q9P2K6
GELVLGGSDPAHYIP	NAPSA	231	O96009