Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	plus-end directed microfilament motor activity	MYO10 MYO19	1.24e-04	3	129	2	GO:0060002
GeneOntologyMolecularFunction	ATP hydrolysis activity	BRIP1 MYO19 KIF1B CHD2 ATP8B1 INO80 DDX55 DHX15 ORC4 MDN1 DYNC1H1	1.38e-04	441	129	11	GO:0016887
GeneOntologyMolecularFunction	ATP-dependent activity	BRIP1 MYO10 MYO19 KIF1B CHD2 ATP8B1 INO80 DDX55 KIF24 DHX15 ORC4 MDN1 DYNC1H1	1.74e-04	614	129	13	GO:0140657
GeneOntologyMolecularFunction	androsterone dehydrogenase (B-specific) activity	AKR1C1 AKR1C3	2.46e-04	4	129	2	GO:0047042
GeneOntologyMolecularFunction	ketoreductase activity	AKR1C1 AKR1C3	2.46e-04	4	129	2	GO:0045703
GeneOntologyMolecularFunction	glutaminase activity	GLS2 GLS	2.46e-04	4	129	2	GO:0004359
GeneOntologyMolecularFunction	chlordecone reductase activity	AKR1C1 AKR1C3	2.46e-04	4	129	2	GO:0047743
GeneOntologyMolecularFunction	pyrophosphatase activity	BRIP1 MYO19 KIF1B CHD2 ATP8B1 INO80 DDX55 ATL1 DHX15 ORC4 MDN1 FHIT DYNC1H1 SEPTIN12 RHOT1	3.43e-04	839	129	15	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	BRIP1 MYO19 KIF1B CHD2 ATP8B1 INO80 DDX55 ATL1 DHX15 ORC4 MDN1 FHIT DYNC1H1 SEPTIN12 RHOT1	3.47e-04	840	129	15	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	BRIP1 MYO19 KIF1B CHD2 ATP8B1 INO80 DDX55 ATL1 DHX15 ORC4 MDN1 FHIT DYNC1H1 SEPTIN12 RHOT1	3.47e-04	840	129	15	GO:0016818
GeneOntologyMolecularFunction	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	AKR1C1 AKR1C3	4.09e-04	5	129	2	GO:0047115
GeneOntologyMolecularFunction	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	AKR1C1 AKR1C3	4.09e-04	5	129	2	GO:0047020
GeneOntologyMolecularFunction	17-beta-ketosteroid reductase (NADPH) activity	AKR1C1 AKR1C3	4.09e-04	5	129	2	GO:0072555
GeneOntologyMolecularFunction	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	AKR1C1 AKR1C3	4.09e-04	5	129	2	GO:0047006
GeneOntologyMolecularFunction	lithocholic acid binding	AKR1C1 AKR1C3	4.09e-04	5	129	2	GO:1902121
GeneOntologyMolecularFunction	ketosteroid monooxygenase activity	AKR1C1 AKR1C3	4.09e-04	5	129	2	GO:0047086
GeneOntologyMolecularFunction	Delta4-3-oxosteroid 5beta-reductase activity	AKR1C1 AKR1C3	4.09e-04	5	129	2	GO:0047787
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	BRIP1 MYO19 KIF1B CHD2 ATP8B1 INO80 DDX55 ATL1 DHX15 ORC4 MDN1 DYNC1H1 SEPTIN12 RHOT1	4.92e-04	775	129	14	GO:0017111
GeneOntologyMolecularFunction	geranylgeranyl reductase activity	AKR1C1 AKR1C3	6.11e-04	6	129	2	GO:0045550
GeneOntologyMolecularFunction	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	AKR1C1 AKR1C3	8.51e-04	7	129	2	GO:0072582
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYO10 MYO19 KIF1B KIF24 DYNC1H1	1.02e-03	118	129	5	GO:0003774
GeneOntologyMolecularFunction	5alpha-androstane-3beta,17beta-diol dehydrogenase activity	AKR1C1 AKR1C3	1.13e-03	8	129	2	GO:0047024
GeneOntologyMolecularFunction	androsterone dehydrogenase activity	AKR1C1 AKR1C3	1.13e-03	8	129	2	GO:0047023
GeneOntologyMolecularFunction	enone reductase activity	AKR1C1 AKR1C3	1.13e-03	8	129	2	GO:0035671
GeneOntologyMolecularFunction	androstan-3-alpha,17-beta-diol dehydrogenase activity	AKR1C1 AKR1C3	1.45e-03	9	129	2	GO:0047044
GeneOntologyMolecularFunction	NADP+ binding	AKR1C1 AKR1C3	1.45e-03	9	129	2	GO:0070401
GeneOntologyMolecularFunction	testosterone 17-beta-dehydrogenase (NADP+) activity	AKR1C1 AKR1C3	1.80e-03	10	129	2	GO:0047045
GeneOntologyMolecularFunction	bile acid binding	AKR1C1 AKR1C3	1.80e-03	10	129	2	GO:0032052
GeneOntologyMolecularFunction	testosterone dehydrogenase [NAD(P)+] activity	AKR1C1 AKR1C3	2.19e-03	11	129	2	GO:0030283
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF460 ZNF549 ZNF507 CHD2 ZNF112 ZNF229 TRIM24 ZNF865 ZNF354C ZNF677 ZNF17 CTCFL ZNF197 ZNF528 ZNF85 TET3 ZNF583	2.72e-03	1244	129	17	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF460 ZNF549 ZNF507 CHD2 ZNF112 ZNF229 TRIM24 ZNF865 ZNF354C ZNF677 ZNF17 CTCFL ZNF197 ZNF528 ZNF85 TET3 ZNF583	3.38e-03	1271	129	17	GO:0000987
GeneOntologyMolecularFunction	aldose reductase (NADPH) activity	AKR1C1 AKR1C3	3.58e-03	14	129	2	GO:0004032
GeneOntologyMolecularFunction	retinal dehydrogenase activity	AKR1C1 AKR1C3	3.58e-03	14	129	2	GO:0001758
GeneOntologyCellularComponent	Golgi cis cisterna	GOLGA8S GOLGA8T GOLGA8R GOLGA8K ATL1	1.92e-06	33	132	5	GO:0000137
GeneOntologyCellularComponent	microtubule	SHROOM3 KIF1B GOLGA8K CFAP141 INO80 ZNF804A KIF24 LRPPRC ASPM MAPRE2 CEP170B DYNC1H1	1.45e-04	533	132	12	GO:0005874
GeneOntologyCellularComponent	Golgi cisterna	GOLGA8S GOLGA8T GOLGA8R GOLGA8K ATL1 CHSY3	2.18e-04	135	132	6	GO:0031985
GeneOntologyCellularComponent	Golgi cisterna membrane	GOLGA8S GOLGA8T GOLGA8R GOLGA8K CHSY3	3.26e-04	94	132	5	GO:0032580
Domain	ZINC_FINGER_C2H2_2	ZNF460 ZNF549 ZNF507 ZNF385A ZNF112 GPATCH8 ZNF229 ZNF865 ZNF804A ZNF354C ZNF677 ZNF17 CTCFL ZNF550 ZNF532 ZNF197 ZNF804B ZNF528 ZNF85 ZNF583 ZNF292	5.87e-08	775	127	21	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF460 ZNF549 ZNF507 ZNF385A ZNF112 GPATCH8 ZNF229 ZNF865 ZNF804A ZNF354C ZNF677 ZNF17 CTCFL ZNF550 ZNF532 ZNF197 ZNF804B ZNF528 ZNF85 ZNF583 ZNF292	6.13e-08	777	127	21	PS00028
Domain	Znf_C2H2-like	ZNF460 ZNF549 ZNF507 ZNF385A ZNF112 GPATCH8 ZNF229 ZNF865 ZNF804A ZNF354C ZNF677 ZNF17 CTCFL ZNF550 ZNF532 ZNF197 ZNF804B ZNF528 ZNF85 ZNF583 ZNF292	9.21e-08	796	127	21	IPR015880
Domain	Znf_C2H2	ZNF460 ZNF549 ZNF507 ZNF385A ZNF112 GPATCH8 ZNF229 ZNF865 ZNF804A ZNF354C ZNF677 ZNF17 CTCFL ZNF550 ZNF532 ZNF197 ZNF804B ZNF528 ZNF85 ZNF583 ZNF292	1.11e-07	805	127	21	IPR007087
Domain	ZnF_C2H2	ZNF460 ZNF549 ZNF507 ZNF385A ZNF112 GPATCH8 ZNF229 ZNF865 ZNF804A ZNF354C ZNF677 ZNF17 CTCFL ZNF550 ZNF532 ZNF197 ZNF804B ZNF528 ZNF85 ZNF583 ZNF292	1.18e-07	808	127	21	SM00355
Domain	-	ZNF460 ZNF549 ZNF507 ZNF112 ZNF229 ZNF865 ZNF354C ZNF677 ZNF17 CTCFL ZNF550 ZNF532 ZNF197 ZNF528 ZNF85 ZNF583 ZNF292	3.55e-06	679	127	17	3.30.160.60
Domain	P-loop_NTPase	ADCY10 BRIP1 MYO10 MYO19 KIF1B CHD2 INO80 DDX55 KIF24 ATL1 DHX15 ORC4 MDN1 N4BP2 ASPM HS6ST3 DYNC1H1 SEPTIN12 RHOT1	4.55e-06	848	127	19	IPR027417
Domain	Znf_C2H2/integrase_DNA-bd	ZNF460 ZNF549 ZNF507 ZNF112 ZNF229 ZNF865 ZNF354C ZNF677 ZNF17 CTCFL ZNF550 ZNF532 ZNF197 ZNF528 ZNF85 ZNF583 ZNF292	4.75e-06	694	127	17	IPR013087
Domain	KRAB	ZNF460 ZNF549 ZNF112 ZNF229 ZNF354C ZNF677 ZNF17 ZNF550 ZNF197 ZNF528 ZNF85 ZNF583	6.10e-06	358	127	12	PS50805
Domain	KRAB	ZNF460 ZNF549 ZNF112 ZNF229 ZNF354C ZNF677 ZNF17 ZNF550 ZNF197 ZNF528 ZNF85 ZNF583	6.10e-06	358	127	12	PF01352
Domain	KRAB	ZNF460 ZNF549 ZNF112 ZNF229 ZNF354C ZNF677 ZNF17 ZNF550 ZNF197 ZNF528 ZNF85 ZNF583	8.28e-06	369	127	12	SM00349
Domain	KRAB	ZNF460 ZNF549 ZNF112 ZNF229 ZNF354C ZNF677 ZNF17 ZNF550 ZNF197 ZNF528 ZNF85 ZNF583	8.51e-06	370	127	12	IPR001909
Domain	-	ADCY10 NAPG IFIT5 TTC3 LRPPRC CTR9 CDC16 TCF25 EDRF1	1.22e-05	207	127	9	1.25.40.10
Domain	Znf_C2H2_jaz	ZNF385A GPATCH8 ZNF804A ZNF804B	1.36e-05	22	127	4	IPR022755
Domain	zf-C2H2_jaz	ZNF385A GPATCH8 ZNF804A ZNF804B	1.36e-05	22	127	4	PF12171
Domain	zf-C2H2	ZNF460 ZNF549 ZNF507 ZNF112 ZNF229 ZNF865 ZNF354C ZNF677 ZNF17 CTCFL ZNF550 ZNF197 ZNF528 ZNF85 ZNF583 ZNF292	1.92e-05	693	127	16	PF00096
Domain	TPR-like_helical_dom	ADCY10 NAPG IFIT5 TTC3 LRPPRC CTR9 CDC16 TCF25 EDRF1	3.10e-05	233	127	9	IPR011990
Domain	Glutaminase	GLS2 GLS	4.59e-05	2	127	2	IPR015868
Domain	Glutaminase	GLS2 GLS	4.59e-05	2	127	2	PF04960
Domain	-	GLS2 GLS	1.37e-04	3	127	2	3.40.710.10
Domain	Beta-lactam/transpept-like	GLS2 GLS	1.37e-04	3	127	2	IPR012338
Domain	zf-C2H2_6	ZNF549 ZNF229 ZNF865 ZNF354C ZNF677 ZNF17 ZNF532 ZNF197 ZNF85	2.99e-04	314	127	9	PF13912
Domain	-	ADCY10 BRIP1 MYO19 CHD2 INO80 DDX55 ATL1 DHX15 ORC4 MDN1 N4BP2 DYNC1H1 SEPTIN12 RHOT1	5.55e-04	746	127	14	3.40.50.300
Domain	DEXDc	BRIP1 CHD2 INO80 DDX55 DHX15	8.92e-04	109	127	5	SM00487
Domain	Helicase_ATP-bd	BRIP1 CHD2 INO80 DDX55 DHX15	9.30e-04	110	127	5	IPR014001
Domain	HIT-like	GALT FHIT	1.60e-03	9	127	2	IPR011146
Domain	-	GALT FHIT	1.60e-03	9	127	2	3.30.428.10
Domain	DNA/RNA_helicase_DEAH_CS	BRIP1 CHD2 DHX15	1.71e-03	35	127	3	IPR002464
Domain	RA	MYO10 RAPGEF4 RASSF6	1.86e-03	36	127	3	PF00788
Domain	ALDOKETO_REDUCTASE_1	AKR1C1 AKR1C3	1.99e-03	10	127	2	PS00798
Domain	ALDOKETO_REDUCTASE_2	AKR1C1 AKR1C3	1.99e-03	10	127	2	PS00062
Domain	ALDOKETO_REDUCTASE_3	AKR1C1 AKR1C3	1.99e-03	10	127	2	PS00063
Domain	Aldo/ket_reductase_CS	AKR1C1 AKR1C3	1.99e-03	10	127	2	IPR018170
Domain	Aldo/keto_reductase	AKR1C1 AKR1C3	1.99e-03	10	127	2	IPR020471
Domain	DEAH_ATP_HELICASE	BRIP1 CHD2 DHX15	2.18e-03	38	127	3	PS00690
Domain	IQ	MYO10 MYO19 PPEF1 ASPM	2.26e-03	81	127	4	SM00015
Domain	RA_dom	MYO10 RAPGEF4 RASSF6	2.52e-03	40	127	3	IPR000159
Domain	TPR_1	IFIT5 TTC3 CTR9 CDC16	3.32e-03	90	127	4	IPR001440
Domain	TPR_1	IFIT5 TTC3 CTR9 CDC16	3.32e-03	90	127	4	PF00515
Domain	IQ_motif_EF-hand-BS	MYO10 MYO19 PPEF1 ASPM	3.32e-03	90	127	4	IPR000048
Domain	Lactamase_B	HAGH CPSF2	3.41e-03	13	127	2	PF00753
Domain	TPR-contain_dom	IFIT5 TTC3 CTR9 CDC16 EDRF1	3.63e-03	150	127	5	IPR013026
Domain	IQ	MYO10 MYO19 PPEF1 ASPM	3.73e-03	93	127	4	PS50096
Domain	ATPase_dyneun-rel_AAA	MDN1 DYNC1H1	3.96e-03	14	127	2	IPR011704
Domain	AAA_5	MDN1 DYNC1H1	3.96e-03	14	127	2	PF07728
Domain	-	FAT4 LGALS4 EYS PAPPA	4.03e-03	95	127	4	2.60.120.200
Domain	Bbox_C	TRIM24 TRIM28	4.55e-03	15	127	2	IPR003649
Domain	BBC	TRIM24 TRIM28	4.55e-03	15	127	2	SM00502
Domain	Lactamase_B	HAGH CPSF2	4.55e-03	15	127	2	SM00849
Domain	TPR_2	IFIT5 TTC3 CTR9	4.77e-03	50	127	3	PF07719
Domain	TPR_2	IFIT5 TTC3 CTR9	4.77e-03	50	127	3	IPR013105
Domain	-	AKR1C1 AKR1C3	5.17e-03	16	127	2	3.20.20.100
Domain	TPR_REGION	IFIT5 TTC3 CTR9 CDC16 EDRF1	5.42e-03	165	127	5	PS50293
Domain	TPR	IFIT5 TTC3 CTR9 CDC16 EDRF1	5.42e-03	165	127	5	PS50005
Domain	NADP_OxRdtase_dom	AKR1C1 AKR1C3	5.84e-03	17	127	2	IPR023210
Domain	Aldo_ket_red	AKR1C1 AKR1C3	5.84e-03	17	127	2	PF00248
Domain	Aldo/ket_red/Kv-b	AKR1C1 AKR1C3	5.84e-03	17	127	2	IPR001395
Domain	Helicase_C	CHD2 INO80 DDX55 DHX15	6.14e-03	107	127	4	PF00271
Domain	HELICc	CHD2 INO80 DDX55 DHX15	6.14e-03	107	127	4	SM00490
Domain	Helicase_C	CHD2 INO80 DDX55 DHX15	6.34e-03	108	127	4	IPR001650
Domain	HELICASE_CTER	CHD2 INO80 DDX55 DHX15	6.55e-03	109	127	4	PS51194
Domain	HELICASE_ATP_BIND_1	CHD2 INO80 DDX55 DHX15	6.55e-03	109	127	4	PS51192
Pathway	WP_15Q11Q13_COPY_NUMBER_VARIATION	GOLGA8T SLF1 GOLGA8R GOLGA8K SERPINH1	5.19e-05	59	97	5	M48104
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF460 ZNF229 ZNF17 ZNF550 TRIM28 ZNF197 MKLN1 ZNF583	5.49e-07	181	134	8	37372979
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	AEN FN1 ZNF507 CHD2 INO80 GPATCH8 TTC3 AKR1C1 DIS3 PDIA4 ORC4 WDHD1 CTR9 MKLN1 AKR1C3 CPSF2 COG4	1.00e-06	1084	134	17	11544199
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	CHD2 INO80 GPATCH8 SERPINH1 AKR1C1 DIS3 THOC5 DHX15 MDN1 WDHD1 ZNF532 TRIM28 CTR9 CDC16 AKR1C3 CPSF2	1.98e-06	1014	134	16	32416067
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	NRAP FN1 KIF1B RIOK3 CHD2 TTC3 DHX15 LRPPRC SYNE2 FTH1 MKLN1	3.85e-06	497	134	11	23414517
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MYO10 KIF1B CUL9 GPATCH8 USP31 TCF25 CLEC16A TET3 CEP170B DYNC1H1	4.34e-06	407	134	10	12693553
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHROOM3 RAPGEF4 ADGRB2 GOLGA8K TTC3 LRPPRC STRN MDN1 TRIM28 N4BP2 PABPC3 SYNE2 CPSF2 CEP170B DYNC1H1	4.94e-06	963	134	15	28671696
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FN1 CUL9 CHD2 SERPINH1 DIS3 ITPR3 DHX15 PDIA4 LRPPRC MDN1 SYNE2 DYNC1H1	9.11e-06	653	134	12	22586326
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FN1 KIF1B RAPGEF4 CUL9 IFIT5 TTC3 ZNF532 CTR9 GLS ZNF197 MKLN1 AKR1C3 ZNF528 ZNF583 COG4 DYNC1H1 ZNF292	9.62e-06	1285	134	17	35914814
Pubmed	Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.	AKR1C1 PIK3C2G AKR1C3	1.20e-05	12	134	3	28893949
Pubmed	ZNF354C is a transcriptional repressor that inhibits endothelial angiogenic sprouting.	ZNF354C TRIM28	1.47e-05	2	134	2	33154469
Pubmed	Expression of Gls and Gls2 glutaminase isoforms in astrocytes.	GLS2 GLS	1.47e-05	2	134	2	25297978
Pubmed	AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer.	AKR1C1 AKR1C3	1.47e-05	2	134	2	16338060
Pubmed	Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers.	AKR1C1 AKR1C3	1.47e-05	2	134	2	23165153
Pubmed	Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase.	GLS2 GLS	1.47e-05	2	134	2	10620514
Pubmed	The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats.	GLS2 GLS	1.47e-05	2	134	2	28526749
Pubmed	Transcriptomic Profiling Reveals AKR1C1 and AKR1C3 Mediate Cisplatin Resistance in Signet Ring Cell Gastric Carcinoma via Autophagic Cell Death.	AKR1C1 AKR1C3	1.47e-05	2	134	2	34830394
Pubmed	Increased plasma glutamate by antipsychotic medication and its relationship to glutaminase 1 and 2 genotypes in schizophrenia -- Juntendo University Schizophrenia Projects (JUSP).	GLS2 GLS	1.47e-05	2	134	2	17669570
Pubmed	Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.	GLS2 GLS	1.47e-05	2	134	2	24276018
Pubmed	TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice.	TRIM24 TRIM28	1.47e-05	2	134	2	25281858
Pubmed	Full-length human glutaminase in complex with an allosteric inhibitor.	GLS2 GLS	1.47e-05	2	134	2	22049910
Pubmed	Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis.	AKR1C1 AKR1C3	1.47e-05	2	134	2	30367463
Pubmed	Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells.	GLS2 GLS	1.47e-05	2	134	2	33610185
Pubmed	Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.	GLS2 GLS	1.47e-05	2	134	2	22225880
Pubmed	Identification of two human glutaminase loci and tissue-specific expression of the two related genes.	GLS2 GLS	1.47e-05	2	134	2	11130979
Pubmed	Co-expression of glutaminase K and L isoenzymes in human tumour cells.	GLS2 GLS	1.47e-05	2	134	2	15496140
Pubmed	Conserved Mitotic Phosphorylation of a Proteasome Subunit Regulates Cell Proliferation.	DHX15 STRN CTR9 CDC16 MAPRE2	1.50e-05	80	134	5	34831298
Pubmed	TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.	SDK2 FN1 SERPINH1 AKR1C1 PDIA4 LRPPRC WDHD1 MAP3K15 AGBL1	1.85e-05	382	134	9	37249651
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	KIF1B ZNF507 CUL9 RIOK3 SERPINH1 DIS3 STRN CTR9 N4BP2 ASPM CEP170B	1.85e-05	588	134	11	38580884
Pubmed	The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.	BRIP1 TRIM24 DHX15 WDHD1 CDC16	1.90e-05	84	134	5	26299517
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	CHD2 INO80 GPATCH8 DDX55 THOC5 DHX15 GGH LRPPRC ZNF532 TRIM28 FTH1 CPSF2 COG4 DYNC1H1 ZNF292	1.95e-05	1082	134	15	38697112
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	MYO10 DDX55 SERPINH1 DHX15 LRPPRC WDHD1 TRIM28 CTR9 CDC16 PLCH2 ASPM TENM1 TCF25 CPSF2	2.45e-05	971	134	14	33306668
Pubmed	A conserved acetylation switch enables pharmacological control of tubby-like protein stability.	RIOK3 PDCD2L DIS3 KBTBD7 STRN TCF25 ZNF292	2.67e-05	223	134	7	33187986
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	FN1 ZNF460 TRIM24 ITPR3 CDC16 SYNE2 COG4 DYNC1H1	3.76e-05	322	134	8	26514267
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	CUL9 ZNF385A GPATCH8 DHX15 LRPPRC STRN TRIM28 N4BP2 CDC16 ZNF804B FTH1	3.95e-05	639	134	11	23443559
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	GLS2 IFIT5 CHD2 DDX55 TTC3 PDIA4 LRPPRC STRN MDN1 CTR9 N4BP2 PABPC3 GLS SYNE2 ASPM TENM1 ZNF292	4.15e-05	1442	134	17	35575683
Pubmed	Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice.	SLCO3A1 CHD2 AGBL1	4.37e-05	18	134	3	31541165
Pubmed	Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.	AKR1C1 AKR1C3	4.41e-05	3	134	2	19320734
Pubmed	Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.	AKR1C1 AKR1C3	4.41e-05	3	134	2	31780644
Pubmed	Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression.	TRIM24 TRIM28	4.41e-05	3	134	2	12096914
Pubmed	Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX.	MYO19 RHOT1	4.41e-05	3	134	2	30111583
Pubmed	Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.	AKR1C1 AKR1C3	4.41e-05	3	134	2	7626489
Pubmed	Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.	AKR1C1 AKR1C3	4.41e-05	3	134	2	21232532
Pubmed	Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.	AKR1C1 AKR1C3	4.41e-05	3	134	2	13678667
Pubmed	Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line.	AKR1C1 AKR1C3	4.41e-05	3	134	2	23183084
Pubmed	Oligomerization of transcriptional intermediary factor 1 regulators and interaction with ZNF74 nuclear matrix protein revealed by bioluminescence resonance energy transfer in living cells.	TRIM24 TRIM28	4.41e-05	3	134	2	12684500
Pubmed	Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.	TRIM24 TRIM28	4.41e-05	3	134	2	9016654
Pubmed	TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer.	TRIM24 TRIM28	4.41e-05	3	134	2	34518220
Pubmed	Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.	BRIP1 KIF1B CTCFL	5.18e-05	19	134	3	14578343
Pubmed	Identification of Modifier Genes in a Mouse Model of Gaucher Disease.	FAT4 THOC5 ITPR3	8.16e-05	22	134	3	27568557
Pubmed	Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.	AKR1C1 AKR1C3	8.80e-05	4	134	2	20124700
Pubmed	Accumulation of type IV collagen in dilated ER leads to apoptosis in Hsp47-knockout mouse embryos via induction of CHOP.	FN1 SERPINH1	8.80e-05	4	134	2	15522896
Pubmed	Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).	AKR1C1 AKR1C3	8.80e-05	4	134	2	10500239
Pubmed	Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.	AKR1C1 AKR1C3	8.80e-05	4	134	2	16508162
Pubmed	AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.	AKR1C1 AKR1C3	8.80e-05	4	134	2	19487289
Pubmed	Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C3	8.80e-05	4	134	2	14967952
Pubmed	Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.	AKR1C1 AKR1C3	8.80e-05	4	134	2	10393440
Pubmed	Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.	AKR1C1 AKR1C3	8.80e-05	4	134	2	15193432
Pubmed	Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.	AKR1C1 AKR1C3	8.80e-05	4	134	2	31479646
Pubmed	Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C3	8.80e-05	4	134	2	15222881
Pubmed	Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.	AKR1C1 AKR1C3	8.80e-05	4	134	2	16191478
Pubmed	Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.	AKR1C1 AKR1C3	8.80e-05	4	134	2	15577209
Pubmed	Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.	AKR1C1 AKR1C3	8.80e-05	4	134	2	10702227
Pubmed	Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.	AKR1C1 AKR1C3	8.80e-05	4	134	2	17034817
Pubmed	Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.	AKR1C1 AKR1C3	8.80e-05	4	134	2	17629694
Pubmed	RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.	AKR1C1 AKR1C3	8.80e-05	4	134	2	29764944
Pubmed	Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.	AKR1C1 AKR1C3	8.80e-05	4	134	2	10526179
Pubmed	Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.	AKR1C1 AKR1C3	8.80e-05	4	134	2	17888864
Pubmed	Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.	AKR1C1 AKR1C3	8.80e-05	4	134	2	17442338
Pubmed	Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma.	TRIM24 TRIM28	8.80e-05	4	134	2	21531907
Pubmed	The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin.	TRIM24 TRIM28	8.80e-05	4	134	2	10318760
Pubmed	Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.	AKR1C1 AKR1C3	8.80e-05	4	134	2	28329705
Pubmed	Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.	AKR1C1 AKR1C3	8.80e-05	4	134	2	16018803
Pubmed	Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C3	8.80e-05	4	134	2	17272929
Pubmed	Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.	AKR1C1 AKR1C3	8.80e-05	4	134	2	19237748
Pubmed	Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.	AKR1C1 AKR1C3	8.80e-05	4	134	2	18667791
Pubmed	Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.	AKR1C1 AKR1C3	8.80e-05	4	134	2	28259989
Pubmed	Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.	AKR1C1 AKR1C3	8.80e-05	4	134	2	21521174
Pubmed	Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.	AKR1C1 AKR1C3	8.80e-05	4	134	2	8274401
Pubmed	Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.	AKR1C1 AKR1C3	8.80e-05	4	134	2	16511129
Pubmed	Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.	AKR1C1 AKR1C3	8.80e-05	4	134	2	10803568
Pubmed	AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.	AKR1C1 AKR1C3	8.80e-05	4	134	2	34590152
Pubmed	Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.	AKR1C1 AKR1C3	8.80e-05	4	134	2	7789999
Pubmed	Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.	ZNF460 MDN1 TRIM28 CDC16 CPSF2	8.97e-05	116	134	5	21549307
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	SHROOM3 DIS3 DHX15 PDIA4 LRPPRC TRIM28 ZNF804B TCF25 DYNC1H1	1.02e-04	477	134	9	31300519
Pubmed	A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.	CUL9 CDC16 DYNC1H1	1.07e-04	24	134	3	33705438
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	MOK TRPC4AP TRIM65 CHGB TTC3 SERPINH1 AKR1C1 KBTBD7 DHX15 PDIA4 SYNE2 TCF25 COG4 EDRF1	1.17e-04	1124	134	14	21900206
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	TRIM65 CHD2 CCDC112 AFAP1L2 GVINP1 TRIM28 DYNC1H1	1.22e-04	284	134	7	29459677
Pubmed	Mitochondrial Raf1 Regulates Glutamine Catabolism.	LGALS4 ITPR3 PDIA4 LRPPRC GLS ASPM AKR1C3	1.33e-04	288	134	7	38496616
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	ADGRB2 SLC25A51 ATL1 LRPPRC STRN TRIM28 CDC16 GLS MKLN1 TENM1 TCF25 MAPRE2 CLEC16A CEP170B	1.34e-04	1139	134	14	36417873
Pubmed	Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family.	AKR1C1 AKR1C3	1.46e-04	5	134	2	7737980
Pubmed	Genome-wide association study of maternal and inherited loci for conotruncal heart defects.	PAPPA FHIT	1.46e-04	5	134	2	24800985
Pubmed	Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.	AKR1C1 AKR1C3	1.46e-04	5	134	2	21851338
Pubmed	The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity.	TRIM28 ZNF197	1.46e-04	5	134	2	12682018
Pubmed	Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family.	TRIM24 TRIM28	1.46e-04	5	134	2	10562550
Pubmed	Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.	AKR1C1 AKR1C3	1.46e-04	5	134	2	17872381
Pubmed	Embryonic lethality of molecular chaperone hsp47 knockout mice is associated with defects in collagen biosynthesis.	FN1 SERPINH1	1.46e-04	5	134	2	10995453
Pubmed	Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.	AKR1C1 AKR1C3	1.46e-04	5	134	2	17064890
Pubmed	Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.	AKR1C1 AKR1C3	1.46e-04	5	134	2	10672042
Pubmed	The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins.	GLS2 GLS	1.46e-04	5	134	2	11163757
Pubmed	TIF1gamma, a novel member of the transcriptional intermediary factor 1 family.	TRIM24 TRIM28	1.46e-04	5	134	2	10022127
Interaction	MRPS24 interactions	ZNF460 HDHD5 CUL9 DDX55 SLC25A51 KBTBD7 ZNF17 LRPPRC TRIM28 GLS MKLN1	2.09e-06	276	132	11	int:MRPS24
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF460 ZNF549 ZNF507 PDCD2L ZNF112 ZNF229 ZNF865 LGALS4 ZNF677 ZNF17 ZNF550 TRIM28 ZNF528 ZNF583	1.11e-05	1192	134	14	chr19q13
Cytoband	10p15-p14	AKR1C1 AKR1C3	1.26e-04	6	134	2	10p15-p14
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF460 ZNF549 ZNF507 ZNF112 ZNF229 ZNF865 ZNF354C ZNF677 ZNF17 CTCFL ZNF550 ZNF532 ZNF197 ZNF528 ZNF85 ZNF583 ZNF292	1.09e-07	718	92	17	28
GeneFamily	DNA helicases	BRIP1 CHD2 INO80	8.23e-05	17	92	3	1167
Coexpression	CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP	KIF1B SLCO3A1 SERPINH1 AKR1C1 SYCP2 GLS AKR1C3 CEP170B DYNC1H1	4.07e-06	239	134	9	M4716
ToppCell	moderate-Epithelial-FOXN4+\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MOK ADAM15 ADGRB2 KIF24 GGH SYCP2 TRIM28 ASPM	1.35e-07	194	134	8	dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF385A ZNF804A EYS ASPM TENM1 NHS PAPPA	1.39e-06	183	134	7	04d3cc76038b8192c915f1c08c3e26f2ad3b3779
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	SHROOM3 FN1 ATP8B1 HMCN2 GLS NHS CHSY3	1.73e-06	189	134	7	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ATP8B1 CHGB FGL2 AFAP1L2 PIK3C2G GLS PAPPA	1.79e-06	190	134	7	078f4be52fa4cc8dd9c8d7a2b6d9631c3d902285
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	MOK CHD2 IHO1 MDN1 ASPM TCF25 ZNF292	1.92e-06	192	134	7	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ATP8B1 CHGB FGL2 AFAP1L2 PIK3C2G GLS PAPPA	1.92e-06	192	134	7	d5ec4cdb15620a5abfc83577353501186c2bc86a
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ATP8B1 CHGB FGL2 AFAP1L2 PIK3C2G GLS PAPPA	1.99e-06	193	134	7	5da60321bcf761913eb30779b6d8b1e933c5e51e
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-B-Plasmablast\|ICU-NoSEP / Disease, condition lineage and cell class	BRIP1 ZNF460 NAPG KIF24 PDIA4 GGH ASPM	2.28e-06	197	134	7	8f35f9741086a38f0e594dce0547b575946f52bb
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-D\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	ADAM15 SERPINH1 AKR1C1 FGL2 PDIA4 AKR1C3 PAPPA	2.35e-06	198	134	7	fd14efd8e6c74a04bde985c08dc34217c0ef1bab
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FAT4 SLF1 ADAM15 RAPGEF4 SERPINH1 SYNE2 MAPRE2	2.52e-06	200	134	7	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	BRIP1 KIF24 FGL2 WDHD1 ASPM ZNF85	1.51e-05	175	134	6	f7d191cde68de8f3457fa62b1df53b6d0dbe5001
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF804A EYS TENM1 NHS PAPPA AGBL1	1.66e-05	178	134	6	6ad46b0720298bcb927fd53468bb4ea0c199ad35
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOK6 RASSF6 SYNE2 TENM1 NHS PAPPA	1.77e-05	180	134	6	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EYS HMCN2 ASPM TENM1 NHS AGBL1	1.89e-05	182	134	6	08aff7112c9dac0ef5540300516a604782b21169
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PPEF1 CHN2 ZNF804A AKR1C1 ZNF804B CHSY3	1.89e-05	182	134	6	205d9ad1ea4b7adee8054496cdde46c9c401a19a
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EYS ASPM TENM1 NHS PAPPA AGBL1	1.89e-05	182	134	6	a3c5c0eff527c8d3848acda14af8f9e99c69b0de
ToppCell	TCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell\|TCGA-Uvea / Sample_Type by Project: Shred V9	SDK2 FN1 MYO19 TRIM65 DENND3 CHSY3	2.13e-05	186	134	6	e8580a2093eb7e50aad55ec7fada850d2fed8ae1
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM3 RASSF6 SYNE2 NHS PAPPA FHIT	2.13e-05	186	134	6	b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF804A EYS ASPM TENM1 NHS PAPPA	2.20e-05	187	134	6	d413fb4b1531b297af5012a392b88128510c2de8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BRIP1 FN1 KIF24 IHO1 ASPM CHSY3	2.20e-05	187	134	6	e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BRIP1 FN1 KIF24 IHO1 ASPM CHSY3	2.20e-05	187	134	6	cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCell	COVID-19-kidney-tDL\|kidney / Disease (COVID-19 only), tissue and cell type	DOK6 AKR1C1 RASSF6 AKR1C3 NHS PAPPA	2.20e-05	187	134	6	d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	SHROOM3 FN1 HMCN2 GLS NHS CHSY3	2.26e-05	188	134	6	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYO10 ATP8B1 AFAP1L2 PIK3C2G PAPPA MAP3K15	2.26e-05	188	134	6	e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF385A ZNF804A EYS ASPM TENM1 NHS	2.26e-05	188	134	6	8de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ATP8B1 FGL2 AFAP1L2 PIK3C2G PAPPA MAP3K15	2.33e-05	189	134	6	bfc76a72b600d641c8fe58346e5d8986c34f3981
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	FN1 RAPGEF4 ATP8B1 PPEF1 AKR1C1 ZNF804B	2.33e-05	189	134	6	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM3 MYO10 AFAP1L2 PIK3C2G PAPPA HS6ST3	2.40e-05	190	134	6	b3bccf4dd95e986db3cee324a6737f5fcc22e8e5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYO10 ATP8B1 AFAP1L2 PIK3C2G PAPPA MAP3K15	2.40e-05	190	134	6	11d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCell	NS-moderate-d_16-33-Epithelial-FOXN4+\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MOK ADAM15 ADGRB2 KIF24 GGH SYCP2	2.40e-05	190	134	6	250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF804A EYS ASPM TENM1 NHS PAPPA	2.40e-05	190	134	6	305fbef734c350cfbf786ca7ff6e07093aab56ea
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYO10 ATP8B1 AFAP1L2 PIK3C2G PAPPA MAP3K15	2.40e-05	190	134	6	b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF804A EYS ASPM TENM1 NHS PAPPA	2.40e-05	190	134	6	e58e4b6fbeb4368f738adac67ec10879c0966f0f
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CHGB TTC3 ZNF804A TENM1 TCF25 CEP170B	2.47e-05	191	134	6	5d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCell	Entopeduncular-Neuronal-Inhibitory\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CHGB TTC3 ZNF804A TENM1 TCF25 CEP170B	2.47e-05	191	134	6	73dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYO10 CHGB AFAP1L2 PIK3C2G PAPPA MAP3K15	2.55e-05	192	134	6	fd08ae787e936cfdb1ab8f19b0fd63005b462709
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ATP8B1 CHGB FGL2 AFAP1L2 PIK3C2G PAPPA	2.55e-05	192	134	6	9e031bf93eb8757fdd0cc22f01b44e48f85532d5
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ATP8B1 CHGB FGL2 AFAP1L2 PIK3C2G PAPPA	2.55e-05	192	134	6	3d777d07878269b87ec7e1f06489cae7c989d633
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYO10 CHGB AFAP1L2 PIK3C2G PAPPA MAP3K15	2.55e-05	192	134	6	bae236c9f1fac77bce28d0a9cf090100d391ff77
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	KIF1B LRPPRC STRN CTR9 N4BP2 DYNC1H1	2.62e-05	193	134	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CHGB FGL2 AFAP1L2 PIK3C2G GLS PAPPA	2.62e-05	193	134	6	e7012f7b53971972299db34fa51ff51a4e4987fe
ToppCell	moderate-Epithelial-FOXN4+\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MOK ADAM15 ADGRB2 KIF24 GGH SYCP2	2.70e-05	194	134	6	5dffa578149104dda33774361e9e77b227b5f1ce
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CHGB FGL2 AFAP1L2 PIK3C2G PAPPA MAP3K15	2.70e-05	194	134	6	d602a0cdb69cd5a3e9ef61ddbab8d920557dd73e
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic-lymphocyte-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	BRIP1 MYO10 SLC25A51 GGH WDHD1 ASPM	2.70e-05	194	134	6	8f4b63b0b9a40765205e4ca6bd94a675a83dbe3d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLCO3A1 ITPR3 STRN TENM1 NHS CLEC16A	2.78e-05	195	134	6	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLCO3A1 ITPR3 STRN TENM1 NHS CLEC16A	2.78e-05	195	134	6	d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO10 KIF1B RAPGEF4 TTC3 RAD51AP2 DYNC1H1	2.78e-05	195	134	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DOK6 ZNF507 LGALS4 SYNE2 TENM1 ZNF292	2.94e-05	197	134	6	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	CHD2 DDX55 SYCP2 ASPM TCF25 ZNF292	2.94e-05	197	134	6	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOK6 SLF1 RAPGEF4 TTC3 GLS CHSY3	3.03e-05	198	134	6	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CHD2 GLS SYNE2 TENM1 TCF25 ZNF292	3.11e-05	199	134	6	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Transverse-B_cell-B_cell_cycling\|B_cell / Region, Cell class and subclass	BRIP1 TRIM65 ZNF804A WDHD1 ASPM CLEC16A	3.11e-05	199	134	6	170ae68963d31f3b821b6f0e8f0c039bea0bc981
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1--L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF804A EYS ASPM TENM1 NHS PAPPA	3.20e-05	200	134	6	4a426ef88376d8bb2b9dc50aa06e7b9fc50ecc9c
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF804A EYS ASPM TENM1 NHS PAPPA	3.20e-05	200	134	6	1276bfa911fddada4235e12e3081baa53164574b
ToppCell	Macroglial-Polydendrocytes-PDGFRA-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DOK6 RAPGEF4 ZNF804A AFAP1L2 TENM1 HS6ST3	3.20e-05	200	134	6	f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCell	Macroglial-Polydendrocytes-PDGFRA--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DOK6 RAPGEF4 ZNF804A AFAP1L2 TENM1 HS6ST3	3.20e-05	200	134	6	cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Cortical_neuron\|5w / Sample Type, Dataset, Time_group, and Cell type.	CHGB CHN2 AKR1C1 ATL1 CCDC112 FTH1	3.20e-05	200	134	6	085060d148158f7d9e938b6c4a3700ccbb3bca15
ToppCell	Macroglial-Polydendrocytes-PDGFRA\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DOK6 RAPGEF4 ZNF804A AFAP1L2 TENM1 HS6ST3	3.20e-05	200	134	6	c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCell	Macroglial-Polydendrocytes-PDGFRA---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DOK6 RAPGEF4 ZNF804A AFAP1L2 TENM1 HS6ST3	3.20e-05	200	134	6	4fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCell	Calu_3\|World / Cell line, Condition and Strain	SLCO3A1 LGALS4 ITPR3 SYNE2 FTH1 AKR1C3	3.20e-05	200	134	6	a549aa08aeefe905653266dae3936094ff55f8e4
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF804A EYS ASPM TENM1 NHS PAPPA	3.20e-05	200	134	6	fbeee1c16ac0a7fe28d90491c8b079f21ce80bdc
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF804A EYS ASPM TENM1 NHS PAPPA	3.20e-05	200	134	6	c6eda342ea0cb37d71d89dbb8d11e819e0745172
ToppCell	Macroglial-Polydendrocytes-PDGFRA----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DOK6 RAPGEF4 ZNF804A AFAP1L2 TENM1 HS6ST3	3.20e-05	200	134	6	310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCell	Macroglial-Polydendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DOK6 RAPGEF4 ZNF804A AFAP1L2 TENM1 HS6ST3	3.20e-05	200	134	6	961858738ce35db8760c8c2e136f8369bc444ccf
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_C\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GOLGA8R FGL2 SYNE2 AKR1C3 CHSY3	8.82e-05	149	134	5	95b21d67d6c335330a508f78d5cc074fdaf92275
ToppCell	Adult-Immune-mast_cell-D175\|Adult / Lineage, Cell type, age group and donor	PDCD2L AFAP1L2 ZNF550 PLCH2 TENM1	1.20e-04	159	134	5	9f53fe2e0f25448d62a591c8e528e9a49b5400d5
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ATP8B1 AFAP1L2 PIK3C2G GLS PAPPA	1.23e-04	160	134	5	7064af50fc10e3ea03badf415306222b74db0f95
ToppCell	ICU-NoSEP-Lymphocyte-B-Plasmablast\|ICU-NoSEP / Disease, Lineage and Cell Type	ZNF460 NAPG PDIA4 GGH ASPM	1.27e-04	161	134	5	8ca34d800551cb0f796293e6bfdcbf58509cc668
ToppCell	390C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	BRIP1 ZNF385A ZNF804A KIF24 ASPM	1.34e-04	163	134	5	aa5ea367f787c1543afb7eb80a801432e1c44011
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-7\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	ADCY10 SOSTDC1 SLCO3A1 AKR1C1 AKR1C3	1.38e-04	164	134	5	81c41e1b5535b7969bcf6fa2456f828e8e8e2ff7
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FGL2 TMPRSS11D AKR1C3 PAPPA MAPRE2	1.51e-04	167	134	5	e242827999caad08b0894d88ab97bc1df41b7650
ToppCell	TCGA-Cervix\|World / Sample_Type by Project: Shred V9	BRIP1 MYO19 SYCP2 WDHD1 TMPRSS11D	1.64e-04	170	134	5	a6cbe253bc60f5d5cb361c7e85ed9928a3155ec8
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination__)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SDK2 MYO19 ZNF112 DENND3 CTR9	1.68e-04	171	134	5	d1e87478d8c0329e662849823f5c7604f20e1b1a
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYCP2 SYNE2 ASPM TENM1 AKR1C3	1.73e-04	172	134	5	86f52f486d67217fc1b8443ab362c975df2974a4
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYCP2 SYNE2 ASPM TENM1 AKR1C3	1.73e-04	172	134	5	fb2df8fea6df5947165f13978f1d1006d15b60fd
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYCP2 SYNE2 ASPM TENM1 AKR1C3	1.73e-04	172	134	5	e38ebb216e4ddcd008148fcbaf709b4f3c83706a
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_2\|343B / Donor, Lineage, Cell class and subclass (all cells)	BRIP1 GPR34 GGH WDHD1 ASPM	1.82e-04	174	134	5	a75ba49ccea6bd3d78ada1092b46deb5202c58a5
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l28\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TRIM65 KBTBD7 ATL1 LGALS4 MAP3K15	1.87e-04	175	134	5	aa168aeb9ad71aa6c0c28a0657c9eb92a0b28183
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-plasmablast-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ATP8B1 ZNF804A PDIA4 GGH RASSF6	1.87e-04	175	134	5	89bf89466191da14896ed8928027f5b911436c22
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF4 CHGB LGALS4 PLCH2 TENM1	1.87e-04	175	134	5	65571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PPEF1 CHN2 ZNF804A AKR1C1 ZNF804B	1.92e-04	176	134	5	ed7ba2a3af3b060dec98b60f09f96000a67f7e63
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO10 CHN2 ZNF804A AKR1C1 ZNF804B	1.92e-04	176	134	5	de746cdf2c777eec88cb03863e128e97ad6e8fb0
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ATP8B1 PPEF1 ZNF804A AKR1C1 ZNF804B	1.97e-04	177	134	5	64fbf799e7b0c4003b2f486cc41b0f7e7c11ea0c
ToppCell	wk_08-11-Epithelial-PNS-FGFBP2+_Neural_progenitor\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ZNF804A SYCP2 ZNF804B TENM1 HS6ST3	1.97e-04	177	134	5	15a5c96ea840376e54933ebe7a8334a11d9ce411
ToppCell	BAL-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	MOK CUL9 ITPR3 FAM151B SYNE2	2.08e-04	179	134	5	68511e87b12b8253de7771e5ccfc5869248b8450
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PLCH2 ASPM TENM1 NHS AGBL1	2.08e-04	179	134	5	d1365d48d1b017a7917f4f63a82ac4720c3d87df
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ATP8B1 AFAP1L2 PIK3C2G GLS PAPPA	2.13e-04	180	134	5	023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO10 CHN2 ZNF804A AKR1C1 ZNF804B	2.13e-04	180	134	5	7a9aa96fb8035020640cc7d3df0c41c730516c6f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PPEF1 CHN2 ZNF804A AKR1C1 ZNF804B	2.19e-04	181	134	5	13270b6ba6a9c8e5681c6f40000c643ce1d9344a
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAT4 ATP8B1 DENND3 LRRC55 AFAP1L2	2.19e-04	181	134	5	4d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_IL7R\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PPEF1 CHN2 ZNF804A AKR1C1 ZNF804B	2.19e-04	181	134	5	3e3c903b522dced6bec5dc447cc3f8bf9a9749e3
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_IL7R\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO10 ATP8B1 ZNF804A AKR1C1 ZNF804B	2.19e-04	181	134	5	b9fe3833a6a56b9fbe5c257393fdbea5bf8ac4a3
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYO10 CHN2 ZNF804A AKR1C1 ZNF804B	2.25e-04	182	134	5	1647367b75b4b107af06bb934394168230cfd7c2
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAT4 ATP8B1 DENND3 ITPR3 AFAP1L2	2.30e-04	183	134	5	3427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF804A ASPM TENM1 NHS PAPPA	2.30e-04	183	134	5	121791ef84e7ce377ed6f5b7953af8865e04958e
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RASSF6 SYNE2 ZNF804B TENM1 NHS	2.30e-04	183	134	5	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4\|TCGA-Thryoid / Sample_Type by Project: Shred V9	GLS2 FN1 ITPR3 FTH1 CEP170B	2.36e-04	184	134	5	d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLCO3A1 CHGB AKR1C1 LRRC55 CCDC112	2.42e-04	185	134	5	ef996f4cdbc3971c6c0460d13df64b075ab22154
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYO10 CHGB PIK3C2G PAPPA MAP3K15	2.42e-04	185	134	5	a0a629e5d2b65f670ea907bd3f5e3caf17687d8f
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal-neurons_B\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLCO3A1 CHGB AKR1C1 LRRC55 CCDC112	2.42e-04	185	134	5	d51342a3979bd728a80e04126059a3fd8a0dbe3b
Disease	Neoplasms, Hormone-Dependent	AKR1C1 AKR1C3	5.67e-05	3	129	2	C0027661
Disease	Growth abnormality	TET3 ZNF292	5.67e-05	3	129	2	C0262361
Disease	Hermaphroditism	AKR1C1 AKR1C3	1.88e-04	5	129	2	C0019269
Disease	Ambiguous Genitalia	AKR1C1 AKR1C3	1.88e-04	5	129	2	C0266362
Disease	Pseudohermaphroditism	AKR1C1 AKR1C3	1.88e-04	5	129	2	C0033804
Disease	Intersex Conditions	AKR1C1 AKR1C3	1.88e-04	5	129	2	C2930618
Disease	Sex Differentiation Disorders	AKR1C1 AKR1C3	1.88e-04	5	129	2	C2930619
Disease	chemokine (C-C motif) ligand 27 measurement	GALT KIF24 USP31 FHIT	2.56e-04	70	129	4	EFO_0008082
Disease	Disorders of Sex Development	AKR1C1 AKR1C3	3.93e-04	7	129	2	C0036875
Disease	ovarian carcinoma	BRIP1 ZNF804A LRPPRC CTR9 N4BP2 ZNF804B HS6ST3	5.44e-04	321	129	7	EFO_0001075
Disease	Prostatic Cancer, Castration-Resistant	TRIM24 AKR1C3	6.69e-04	9	129	2	C3658266
Disease	Prostatic Neoplasms, Castration-Resistant	TRIM24 AKR1C3	6.69e-04	9	129	2	C3658267
Disease	Abnormality of the face	TET3 ZNF292	6.69e-04	9	129	2	C4025871
Disease	beta-amyloid 1-42 measurement, cerebrospinal fluid biomarker measurement	FAT4 MAPRE2	1.67e-03	14	129	2	EFO_0004670, EFO_0006794
Disease	forehead morphology measurement	BRIP1 ADAM15	1.92e-03	15	129	2	EFO_0007844
Disease	Liver Cirrhosis, Experimental	AEN GLS2 TRIM24 SERPINH1 AKR1C1 FGL2 GGH GLS AKR1C3 HAGH	2.18e-03	774	129	10	C0023893
Disease	memory performance	KIF1B EYS N4BP2 SYNE2 ZNF804B HS6ST3 AGBL1	2.20e-03	409	129	7	EFO_0004874
Disease	cortical surface area measurement	SHROOM3 GLS2 ADAM15 KIF1B CUL9 ZNF354C DENND3 STRN ANGPTL2 GLS PAPPA MAPRE2 AGBL1 RHOT1	2.30e-03	1345	129	14	EFO_0010736
Disease	melanoma	TRPC4AP EYS HMCN2 MKLN1	2.31e-03	126	129	4	EFO_0000756
Disease	Charcot-Marie-Tooth disease type 2	KIF1B DYNC1H1	2.47e-03	17	129	2	cv:C0270914
Disease	cystathionine measurement	DOK6 AKR1C3	3.09e-03	19	129	2	EFO_0010474
Disease	fumarate measurement	EYS AFAP1L2	3.77e-03	21	129	2	EFO_0010480
Disease	lung cancer	BRIP1 ATP8B1	3.77e-03	21	129	2	MONDO_0008903
Disease	ceramide measurement	ATP8B1 EYS MDN1 SYNE2 FHIT	3.80e-03	235	129	5	EFO_0010222
Disease	neurodegenerative disease (implicated_via_orthology)	FAT4 CLEC16A DYNC1H1 RHOT1	3.83e-03	145	129	4	DOID:1289 (implicated_via_orthology)
Disease	fat intake measurement	NRAP CHN2	4.14e-03	22	129	2	EFO_0010809
Disease	proprotein convertase subtilisin/kexin type 9 measurement	ZNF528 FHIT	4.14e-03	22	129	2	EFO_0009312

Protein segments in the cluster

Peptide	Gene	Start	Entry
FNQYSSFNEHRKIHT	ZNF354C	421	Q86Y25
QSQAEAHYKGNRHAR	ZNF385A	86	Q96PM9
HELNQKFHTFDRYRS	ADGRB2	1486	O60241
HNDFQALKYVHPRSQ	AEN	196	Q8WTP8
HSHFYNQKSDFRIEH	CCDC112	6	Q8NEF3
KQLLNAHFRKYHDAN	CTCFL	526	Q8NI51
VYAVDFNHKREIHLN	CPSF2	171	Q9P2I0
FRHIDSAHLYNNEEQ	AKR1C3	46	P42330
ADHSEAQKYRDFQHL	ADAM15	221	Q13444
FIKQRDYHQQFRHVQ	COG4	321	Q9H9E3
YLVFKDDRNTEHQVH	GVINP1	916	Q7Z2Y8
HYRDKHNAKGEAIFN	GPR34	206	Q9UPC5
SDADIIQHYKQFRSH	FAT4	4631	Q6V0I7
RDNHLHFYQDRNRSK	AFAP1L2	376	Q8N4X5
HFKQHRQYNDKLEIS	LINC02910	26	Q8N268
HKYQHLATLAHNQSE	ANGPTL2	181	Q9UKU9
EFIHQYENNRILKFH	ADCY10	1401	Q96PN6
KQHAVINYDQDRDEH	CEP170B	41	Q9Y4F5
TLLNVYHAFKQNHES	DHX15	626	O43143
RDVKNHLNYEHRVFN	DENND3	371	A2RUS2
NHYRAFLSAKHQRQV	ASPM	2891	Q8IZT6
YGDHRDASQHNHNKI	ATP8B1	476	O43520
DLNSEKTQYANHHHI	AGBL1	371	Q96MI9
DFHRKNDSALYINHQ	RAD51AP2	916	Q09MP3
RQKNRASINGHFYNH	RASSF6	206	Q6ZTQ3
LSRKHEEDHSQFYLN	PIK3C2G	376	O75747
HNHLKADYEKALRNF	PIK3C2G	1001	O75747
NFHNYDNLRHFAKKL	GLS	526	O94925
NYNNGHRKFLAAAHN	GOLGA8S	531	H3BPF8
RHSQEDYRKNQEHIA	ITPR3	561	Q14573
HFKAQALKNAENAYH	INO80	446	Q9ULG1
ALKNAENAYHIHQAR	INO80	451	Q9ULG1
KVYANGQHLFDFAHR	LGALS4	286	P56470
FDLFAHHKNQTLLYN	ORC4	161	O43929
HAKRLAHLDLSYNNF	LRRC55	111	Q6ZSA7
QQSHHQFRKRLSEEY	MDN1	3376	Q9NU22
HYEFHLKFQLANNHS	EYS	2441	Q5T1H1
SNYNNGHRKFLAAAH	GOLGA8T	536	H3BQL2
RHAQKAHQLQSDVKY	NRAP	1641	Q86VF7
EKLQQHFVAHYLRAQ	MYO19	436	Q96H55
NRAAHLEEFHYQTKE	EDRF1	761	Q3B7T1
FGAHLRHSKQSQQNY	IHO1	61	Q8IYA8
HEYTINNLKFARHVE	HAGH	221	Q16775
ALNQAGHSEKHYNLN	HMCN2	2151	Q8NDA2
DFQNNKHRYLLASEN	KIF1B	411	O60333
EYFHQDDHNNLTDKH	ARNTL2	406	Q8WYA1
ADEKFNQLVHFLRNH	DDX55	251	Q8NHQ9
FDNHINSYDHAHKQR	GPATCH8	151	Q9UKJ3
LNHHAYLFLQSTFDK	RHOT1	301	Q8IXI2
FVNLDHAHSLLRDYQ	PDCD2L	201	Q9BRP1
YHAANHKAQTNEALK	FAM151B	36	Q6UXP7
DDGHSFQYLHQKQFL	GANC	816	Q8TET4
LEKLHSQHANNHFYV	MYO10	521	Q9HD67
HQKEREEHLRFYHQQ	KIF24	756	Q5T7B8
EVQAKEEHLRQYFHQ	LRPPRC	596	P42704
SLFNFHNYDNLRHCA	GLS2	456	Q9UI32
AHQALQHPYFQEQRK	MOK	276	Q9UQ07
DAFDHHKLRSQAQSY	KBTBD7	181	Q8WVZ9
HKLRSQAQSYIAHNF	KBTBD7	186	Q8WVZ9
DFQHHQLAEAFKQYN	PAPPA	376	Q13219
AKDLFQQRYHHTKQL	HS6ST3	411	Q8IZP7
YVNFQHTKDAEHALD	PABPC3	56	Q9H361
DLQVELKRQYNDHHS	BRIP1	791	Q9BX63
ALTHNDNHFNYEKTH	CHN2	201	P52757
NFAKYFLHQSHEERE	FTH1	51	P02794
AARCHYAAKEHQQAL	CDC16	76	Q13042
DFHRNDSIYEELQKH	FHIT	106	P49789
QEFHRKSENTAIHHY	IFIT5	386	Q13325
NYNNGHRKFLAAAHN	GOLGA8K	536	D6RF30
QYIKHNDSKNIFHAA	ATL1	431	Q8WXF7
AYFRNFHKVTELHNI	DOK6	51	Q6PKX4
LAEFFVNEARKNNHH	GGH	271	Q92820
RDNYNHPNKRHFSNA	CHD2	1621	O14647
DDITYNVNDTFHKRH	FN1	521	P02751
AATFRANDHQHIRYN	GALT	21	P07902
VLNHLANHFFFKKDY	CTR9	271	Q6PD62
EHEYIHNFKLLQASF	MAPRE2	111	Q15555
DALRFNKHYNHDLKF	FGL2	341	Q14314
NHYANLFHEKRSELE	DYNC1H1	3181	Q14204
KRFQDYNERCTFHHQ	CUL9	2291	Q8IWT3
QAALHQLFEKEHQQY	CFAP141	71	Q5VU69
SNYNNGHRKFLAAAH	GOLGA8R	536	I6L899
YEVDSNHQKAHSFVN	SDK2	2061	Q58EX2
NHQKAHSFVNHYISD	SDK2	2066	Q58EX2
REEARFQDKQYSSHH	CHGB	496	P05060
FQDKQYSSHHTAEKR	CHGB	501	P05060
HYNVHIDDSQVNKLA	PPEF1	601	O14829
LADQHNIKFHYAFAL	MAP3K15	316	Q6ZN16
LNHVDQEHHFQDKYL	RAPGEF4	271	Q8WZA2
TAHEDRHIKFYDNNT	STRN	681	O43815
SDHHENKYLLLNNQE	TRPC4AP	466	Q8TEL6
NQTHRTKFIYNLEDH	SLCO3A1	686	Q9UIG8
TYRDILEHHLQNNKF	SYNE2	1121	Q8WXH0
QYNDHLDKVRGHRAN	NHS	686	Q6T4R5
LKHFRQHNYTEAFES	MKLN1	181	Q9UL63
QDHKHHDKFTNTYQA	SLC25A51	146	Q9H1U9
GANLFHQYLQKATHD	HDHD5	321	Q9BXW7
KQHYNCEHSKINFRD	SERPINH1	151	P50454
IDQLSHFHNKRDSAY	SHROOM3	246	Q8TF72
AAILNNAHYLENLHF	TENM1	2551	Q9UKZ4
AANNLREDYKFHHTF	PDIA4	326	P13667
QEKHFYTFTNEHHRE	DIS3	116	Q9Y2L1
FRHIDSAHLYNNEEQ	AKR1C1	46	Q04828
YEHNRKGYIQDLHNS	CHSY3	371	Q70JA7
LKLNNHTVHFFYNEH	CLEC16A	151	Q2KHT3
HVFNALKQHAYSEER	RIOK3	201	O14730
HNNYKSATHENDIAL	TMPRSS11D	261	O60235
YRHFDQHIENQKVSV	ZNF532	921	Q9HCE3
HKEHRYQFIEEAFQN	TRIM24	251	O15164
YRSNFVLHNKSHNEK	ZNF460	291	Q14592
FSQNAYLIDHQRLHK	ZNF197	491	O14709
FRDASYLLKHQAAHA	ZNF865	416	P0CJ78
DKQYHKHQEFDNHIN	ZNF804B	61	A4D1E1
KHQEFDNHINSYDHA	ZNF804B	66	A4D1E1
DNHINSYDHAHKQRL	ZNF804B	71	A4D1E1
LNSKYLFVEHQRTHN	ZNF549	256	Q6P9A3
ENNRALFHAAKAYEQ	NAPG	66	Q99747
YSNHKDHLDAASLQR	PLCH2	251	O75038
RSVIFHNHLDYLAKN	WDHD1	731	O75717
HINENYIQSKREESH	SYCP2	1236	Q9BX26
QDLKDITHNIHYENY	SEPTIN12	296	Q8IYM1
FNSYAELLTHRKEHQ	ZNF292	761	O60281
RADKNAAAYFEGHHL	TTC3	1376	P53804
DFCAHAHKDQHNLYN	TET3	1071	O43151
VENFHAQAEKHFHYQ	SLF1	936	Q9BQI6
KRYTRQHNESSHNFE	SOSTDC1	166	Q6X4U4
KGFSHNSYLQAHQRV	ZNF229	496	Q9UJW7
SNLGDHQKSYNREKH	ZNF677	556	Q86XU0
QCEESFHYKSQLRNH	ZNF507	701	Q8TCN5
FHYKSQLRNHEREQH	ZNF507	706	Q8TCN5
HNIYEKAFSHSLDLN	ZNF112	361	Q9UJU3
EKAFSNRAHLIQHYI	ZNF550	321	Q7Z398
KSHLLNKYRNNFDHA	ZNF528	156	Q3MIS6
YVKVAHKFSNSNRHE	ZNF85	151	Q03923
NNNLNHLKFGLDYHR	USP31	416	Q70CQ4
FDQAHKQYETARHLP	THOC5	251	Q13769
NRHFYLSRQDQQVKH	TRIM65	341	Q6PJ69
EHSEEYQQAQHKFLV	TCF25	251	Q9BQ70
RKAFSQYAHLAQHQR	ZNF583	386	Q96ND8
LFRYNSDLIKHQRNH	ZNF17	226	P17021
DCQLNAHKDHQYQFL	TRIM28	231	Q13263
AHKDHQYQFLEDAVR	TRIM28	236	Q13263
EFDNHINSYDHAHKQ	ZNF804A	71	Q7Z570
KDHNYSLEHTVQFLN	N4BP2	1546	Q86UW6