Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	extracellularly glycine-gated ion channel activity	GLRA1 GLRA3	1.15e-04	6	56	2	GO:0016933
GeneOntologyMolecularFunction	extracellularly glycine-gated chloride channel activity	GLRA1 GLRA3	1.15e-04	6	56	2	GO:0016934
GeneOntologyMolecularFunction	inhibitory extracellular ligand-gated monoatomic ion channel activity	GLRA1 GLRA3	2.14e-04	8	56	2	GO:0005237
HumanPheno	Exaggerated startle response	SLC6A9 GLRA1 ZMYM2 MTHFS	1.42e-05	33	24	4	HP:0002267
Domain	Glycine_rcpt_A	GLRA1 GLRA3	5.09e-05	4	55	2	IPR008127
Domain	PH_dom-like	MTMR4 FRMPD4 DOCK9 SBF2 PLD1 PLCH1 PHLDB2	2.41e-04	426	55	7	IPR011993
Domain	Myotubularin-like_Pase_dom	MTMR4 SBF2	7.57e-04	14	55	2	IPR010569
Domain	PPASE_MYOTUBULARIN	MTMR4 SBF2	7.57e-04	14	55	2	PS51339
Domain	Myotubularin_fam	MTMR4 SBF2	7.57e-04	14	55	2	IPR030564
Domain	Myotub-related	MTMR4 SBF2	7.57e-04	14	55	2	PF06602
Domain	-	MTMR4 DOCK9 SBF2 PLD1 PLCH1 PHLDB2	9.88e-04	391	55	6	2.30.29.30
Domain	PH	DOCK9 SBF2 PLD1 PLCH1 PHLDB2	1.34e-03	278	55	5	SM00233
Domain	PH_DOMAIN	DOCK9 SBF2 PLD1 PLCH1 PHLDB2	1.36e-03	279	55	5	PS50003
Domain	PH_domain	DOCK9 SBF2 PLD1 PLCH1 PHLDB2	1.38e-03	280	55	5	IPR001849
Domain	GABAA/Glycine_rcpt	GLRA1 GLRA3	2.07e-03	23	55	2	IPR006028
Domain	Calcineurin-like_PHP_ApaH	SMPD1 PPEF1	3.06e-03	28	55	2	IPR004843
Domain	Metallophos	SMPD1 PPEF1	3.06e-03	28	55	2	PF00149
Domain	Metallo-depent_PP-like	SMPD1 PPEF1	3.51e-03	30	55	2	IPR029052
Domain	-	SMPD1 PPEF1	3.51e-03	30	55	2	3.60.21.10
Domain	PH	DOCK9 SBF2 PLD1 PHLDB2	4.60e-03	229	55	4	PF00169
Domain	RGS	RGS9 SNX13	4.76e-03	35	55	2	PF00615
Domain	RGS	RGS9 SNX13	4.76e-03	35	55	2	SM00315
Domain	RGS	RGS9 SNX13	5.03e-03	36	55	2	PS50132
Domain	RGS	RGS9 SNX13	5.88e-03	39	55	2	IPR016137
Domain	PX	PLD1 SNX13	7.44e-03	44	55	2	SM00312
Domain	Neurotransmitter_ion_chnl_CS	GLRA1 GLRA3	7.77e-03	45	55	2	IPR018000
Domain	Neur_chan_memb	GLRA1 GLRA3	8.11e-03	46	55	2	PF02932
Domain	Neur_chan_LBD	GLRA1 GLRA3	8.46e-03	47	55	2	PF02931
Domain	NEUROTR_ION_CHANNEL	GLRA1 GLRA3	8.46e-03	47	55	2	PS00236
Domain	Neurotrans-gated_channel_TM	GLRA1 GLRA3	8.46e-03	47	55	2	IPR006029
Domain	-	GLRA1 GLRA3	8.46e-03	47	55	2	2.70.170.10
Domain	Neur_channel	GLRA1 GLRA3	8.46e-03	47	55	2	IPR006201
Domain	Neur_chan_lig-bd	GLRA1 GLRA3	8.46e-03	47	55	2	IPR006202
Pubmed	Glycine receptors support excitatory neurotransmitter release in developing mouse visual cortex.	SLC6A9 GLRA1 GLRA3	1.38e-07	7	56	3	22988142
Pubmed	Characterization of the glycinergic input to bipolar cells of the mouse retina.	GLRA1 GLRA3	2.55e-06	2	56	2	16420443
Pubmed	Probing glycine receptor stoichiometry in superficial dorsal horn neurones using the spasmodic mouse.	GLRA1 GLRA3	2.55e-06	2	56	2	21486794
Pubmed	Phosphorylation of α3 glycine receptors induces a conformational change in the glycine-binding site.	GLRA1 GLRA3	2.55e-06	2	56	2	23834509
Pubmed	Multifunctional basic motif in the glycine receptor intracellular domain induces subunit-specific sorting.	GLRA1 GLRA3	2.55e-06	2	56	2	19959465
Pubmed	Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit.	GLRA1 GLRA3	7.63e-06	3	56	2	17154252
Pubmed	Glycinergic input of small-field amacrine cells in the retinas of wildtype and glycine receptor deficient mice.	GLRA1 GLRA3	7.63e-06	3	56	2	17920294
Pubmed	Noncanonical NF-κB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer.	IDO1 RELB	7.63e-06	3	56	2	25063873
Pubmed	A human MAP kinase interactome.	KMT2C CSN1S1 SPTAN1 LAMA4 ZMYM2 HELZ MAP3K3	1.28e-05	486	56	7	20936779
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	KMT2C NUGGC DOCK9 POLR2B ALDH1L1 QARS1 C8orf33	1.48e-05	497	56	7	36774506
Pubmed	Glycinergic input of widefield, displaced amacrine cells of the mouse retina.	GLRA1 GLRA3	1.52e-05	4	56	2	19528249
Pubmed	Expression and mRNA splicing of glycine receptor subunits and gephyrin during neuronal differentiation of P19 cells in vitro, studied by RT-PCR and immunocytochemistry.	GLRA1 GLRA3	1.52e-05	4	56	2	9051263
Pubmed	Alpha subunit-dependent glycine receptor clustering and regulation of synaptic receptor numbers.	GLRA1 GLRA3	1.52e-05	4	56	2	28883437
Pubmed	Activation of glycine receptor phase-shifts the circadian rhythm in neuronal activity in the mouse suprachiasmatic nucleus.	GLRA1 GLRA3	1.52e-05	4	56	2	21486797
Pubmed	Tagging genes with cassette-exchange sites.	PHAF1 KMT2C DOCK9 POLR2B HELZ SMARCAD1	1.65e-05	335	56	6	15741177
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	SPTAN1 POLR2B TUBGCP3 TMEM209 SMARCAD1 EMC2 PLCH1 PLOD2 CLUH ATP6V0A2 DDX10	2.13e-05	1487	56	11	33957083
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	POLR2B PABPC4 ZMYM2 HELZ PLD1 QARS1	2.40e-05	358	56	6	32460013
Pubmed	Developmental regulation of glycine receptors at efferent synapses of the murine cochlea.	GLRA1 GLRA3	2.54e-05	5	56	2	21850450
Pubmed	Native glycine receptor subtypes and their physiological roles.	GLRA1 GLRA3	2.54e-05	5	56	2	18721822
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SPTAN1 ZMYM2 SMARCC2 HELZ SMARCAD1 ZNF224 CLUH PHLDB2	3.21e-05	774	56	8	15302935
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	MTMR4 SPTAN1 POLR2B PABPC4 SMARCC2 RELB SMARCAD1 QARS1 PLOD2 CLUH	3.75e-05	1297	56	10	33545068
Pubmed	Gene structure and glial expression of the glycine transporter GlyT1 in embryonic and adult rodents.	SLC6A9 GLRA1	3.80e-05	6	56	2	7891186
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	POLR2B TUBGCP3 SMARCC2 HELZ SMARCAD1 PLD1 REV3L PHLDB2 ZNF461	6.82e-05	1116	56	9	31753913
Pubmed	Combined metabonomic and quantitative real-time PCR analyses reveal systems metabolic changes in Jurkat T-cells treated with HIV-1 Tat protein.	IDO1 SMPD1	7.09e-05	8	56	2	23025307
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	SPTAN1 POLR2B PABPC4 SMARCC2 DDX10	8.05e-05	274	56	5	34244482
Pubmed	Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study.	ALDH1L1 MTHFS	9.10e-05	9	56	2	17119116
Pubmed	USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells.	SPTAN1 ALDH1L1	1.14e-04	10	56	2	36653359
Pubmed	Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.	MTMR4 SBF2	1.14e-04	10	56	2	9736772
Pubmed	One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia.	ALDH1L1 MTHFS	1.14e-04	10	56	2	17891500
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	AMPD2 POLR2B TMEM209 EMC2 QARS1 PLOD2 C8orf33 DDX10	1.26e-04	942	56	8	31073040
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	KMT2C POLR2B ZMYM2 SMARCC2	1.55e-04	167	56	4	20362541
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	PHAF1 SPTAN1 PABPC4 HELZ QARS1 CLUH DDX10	1.57e-04	724	56	7	36232890
Pubmed	Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair.	POLR2B REV3L	1.66e-04	12	56	2	28700933
Pubmed	Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.	ALDH1L1 MTHFS	1.96e-04	13	56	2	19936946
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	POLR2B TMEM209 SMARCC2 C8orf33 DDX10	1.97e-04	332	56	5	25693804
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	JRK PABPC4 TUBGCP3 EMC2 PLOD2 PHLDB2 DDX10	2.02e-04	754	56	7	33060197
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	POLR2B ZMYM2 SMARCC2 SMARCAD1 DDX10	2.23e-04	341	56	5	32971831
Pubmed	Transcriptional map of chromosome region 6q16-->q21.	LAMA4 REV3L	2.29e-04	14	56	2	10575223
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SPTAN1 POLR2B TUBGCP3 SMARCC2 SMARCAD1 MTHFS QARS1 PHLDB2 DDX10	2.89e-04	1353	56	9	29467282
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	SPTAN1 PABPC4 REV3L PLOD2	2.91e-04	197	56	4	20811636
Pubmed	Conserved Mitotic Phosphorylation of a Proteasome Subunit Regulates Cell Proliferation.	AMPD2 POLR2B TMEM209	2.98e-04	80	56	3	34831298
Pubmed	A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome.	HELZ RGS9 OPN1SW	3.09e-04	81	56	3	16110338
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SPTAN1 PABPC4 TUBGCP3 SMARCC2 PLD1 QARS1 PLOD2 C8orf33 DDX10	3.19e-04	1371	56	9	36244648
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	KMT2C AMPD2 DOCK9 SBF2 POLR2B PLD1 MAP3K3 ATP6V0A2	3.27e-04	1084	56	8	11544199
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	AMPD2 SPTAN1 POLR2B PABPC4 SMARCC2 SMARCAD1 EMC2 QARS1 CLUH	4.02e-04	1415	56	9	28515276
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	SPTAN1 POLR2B PABPC4 SMARCC2 PLOD2	4.13e-04	390	56	5	17643375
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	POLR2B PLD1 EMC2 ATP6V0A2 TPCN1	4.22e-04	392	56	5	33144569
Pubmed	Human transcription factor protein interaction networks.	KMT2C SPTAN1 PABPC4 ZMYM2 SMARCC2 HELZ RELB QARS1 DDX10	4.32e-04	1429	56	9	35140242
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	SPTAN1 PABPC4 ZMYM2 SMARCC2 QARS1	4.32e-04	394	56	5	27248496
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	ZMYM2 SMARCC2 RELB SMARCAD1 REV3L QARS1 PLOD2	4.37e-04	857	56	7	25609649
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	AMPD2 MTMR4 SPTAN1 HELZ PLCH1 MAP3K3 PHLDB2	4.49e-04	861	56	7	36931259
Pubmed	Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.	SMARCC2 RELB	5.24e-04	21	56	2	20460684
Pubmed	Prdm13 regulates subtype specification of retinal amacrine interneurons and modulates visual sensitivity.	SLC6A9 OPN1SW	5.24e-04	21	56	2	25995483
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	SPTAN1 PABPC4 SMARCC2 HELZ CLUH DDX10	6.27e-04	653	56	6	22586326
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	TUBGCP3 HELZ PHLDB2	6.42e-04	104	56	3	31240132
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	CSN1S1 POLR2B PABPC4 SMARCC2	6.52e-04	244	56	4	29884807
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	SPTAN1 POLR2B PABPC4 TMEM209 HELZ RELB REV3L	6.74e-04	922	56	7	27609421
Pubmed	Elavl2 Regulates Retinal Function Via Modulating the Differentiation of Amacrine Cells Subtype.	SLC6A9 OPN1SW	6.87e-04	24	56	2	34061953
Pubmed	Early B-cell factors are required for specifying multiple retinal cell types and subtypes from postmitotic precursors.	SLC6A9 GLRA1	6.87e-04	24	56	2	20826655
Pubmed	Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.	ALDH1L1 MTHFS	6.87e-04	24	56	2	17937387
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	POLR2B TMEM209 SMARCC2 QARS1 PLOD2	7.12e-04	440	56	5	34244565
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	PABPC4 TUBGCP3 PHLDB2	7.16e-04	108	56	3	19531213
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	SPTAN1 POLR2B QARS1 C8orf33 DDX10	7.19e-04	441	56	5	31239290
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	AMPD2 SPTAN1 HELZ QARS1 PHLDB2	7.57e-04	446	56	5	24255178
Pubmed	Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.	GLRA1 GLRA3	8.71e-04	27	56	2	19723784
Pubmed	Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation.	SMARCC2 RELB	9.37e-04	28	56	2	30037996
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	PABPC4 ZMYM2 SMARCC2 DDX10	9.63e-04	271	56	4	32433965
Pubmed	Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.	ALDH1L1 MTHFS	1.01e-03	29	56	2	19048631
Pubmed	LINKIN, a new transmembrane protein necessary for cell adhesion.	POLR2B PABPC4 SMARCC2 RELB QARS1	1.05e-03	480	56	5	25437307
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	MTMR4 POLR2B TMEM209 HELZ PLCH1 CLUH	1.14e-03	733	56	6	34672954
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	KMT2C POLR2B	1.15e-03	31	56	2	20516061
Pubmed	Maf1 controls retinal neuron number by both RNA Pol III- and Pol II-dependent mechanisms.	SLC6A9 OPN1SW	1.15e-03	31	56	2	38089586
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	POLR2B PABPC4 SMARCC2 EMC2 QARS1 PHLDB2 DDX10	1.24e-03	1024	56	7	24711643
Pubmed	The Trim family of genes and the retina: Expression and functional characterization.	SLC6A9 OPN1SW	1.30e-03	33	56	2	30208054
Pubmed	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.	PABPC4 TUBGCP3 PLOD2 DDX10	1.37e-03	298	56	4	32353859
Pubmed	Polo-Like Kinase 3 Appears Dispensable for Normal Retinal Development Despite Robust Embryonic Expression.	SLC6A9 OPN1SW	1.38e-03	34	56	2	26949938
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	SLC6A9 GLRA1 GLRA3 PLD1	1.40e-03	300	56	4	19086053
Pubmed	Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma.	ALDH1L1 MTHFS	1.55e-03	36	56	2	18830263
GeneFamily	Glycine receptors	GLRA1 GLRA3	5.00e-05	5	41	2	868
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR4 SBF2	5.17e-04	15	41	2	903
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	DOCK9 SBF2 PLD1 PHLDB2	1.19e-03	206	41	4	682
GeneFamily	Phospholipases	PLD1 PLCH1	4.08e-03	42	41	2	467
Coexpression	GSE37533_PPARG1_FOXP3_VS_FOXP3_TRANSDUCED_CD4_TCELL_PIOGLITAZONE_TREATED_DN	MTMR4 TMEM168 IDO1 POLR2B PABPC4 REV3L SNX13	1.95e-07	199	55	7	M8974
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	DOCK9 POLR2B TUBGCP3 ZMYM2 HELZ REV3L EMC2 PLOD2 SNX13 DDX10	1.01e-05	856	55	10	M4500
Coexpression	BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP	JRK LAMA4 ZMYM2 SMARCC2 RGS9 QARS1 PLOD2	1.65e-05	389	55	7	M6520
Coexpression	BASAKI_YBX1_TARGETS_DN	IDO1 SBF2 ZMYM2 HELZ PLOD2 SLC3A1 TPCN1	1.91e-05	398	55	7	M14877
Coexpression	GSE21033_CTRL_VS_POLYIC_STIM_DC_12H_DN	LRRC42 PABPC4 TUBGCP3 TMEM209 PLD1	6.28e-05	200	55	5	M7717
Coexpression	GSE37532_WT_VS_PPARG_KO_VISCERAL_ADIPOSE_TISSUE_TCONV_DN	AMPD2 MTMR4 TMEM168 PABPC4 SNX13	6.28e-05	200	55	5	M8966
Coexpression	GSE24026_PD1_LIGATION_VS_CTRL_IN_ACT_TCELL_LINE_DN	AMPD2 POLR2B PABPC4 TUBGCP3 GLRA3	6.28e-05	200	55	5	M4538
Coexpression	GSE17721_CTRL_VS_CPG_8H_BMDC_UP	PABPC4 SMARCAD1 ALDH1L1 PLD1 REV3L	6.28e-05	200	55	5	M3767
Coexpression	GSE2770_UNTREATED_VS_IL12_TREATED_ACT_CD4_TCELL_2H_UP	SPTAN1 ZMYM2 MTHFS MAP3K3 ATP6V0A2	6.28e-05	200	55	5	M6090
Drug	spermine	CSN1S1 SPTAN1 POLR2B SMPD1 RELB REV3L MTHFS PLCH1	4.48e-06	394	55	8	CID000001103
Drug	dl-Lysine	CSN1S1 LAMA4 PTGDR QARS1 PPEF1 PLOD2 SLC3A1	6.09e-06	290	55	7	CID000000866
Drug	L-cycloserine	SLC6A9 GLRA1 GLRA3 SMPD1	1.97e-05	66	55	4	CID000000401
Drug	Z-Gly	CSN1S1 GLRA1 GLRA3	1.99e-05	22	55	3	CID000014349
Drug	iso-THAZ	GLRA1 GLRA3	3.43e-05	4	55	2	CID003047783
Drug	protostrychnine	GLRA1 GLRA3	3.43e-05	4	55	2	CID005320746
Drug	7-nitroindoline	GLRA1 GLRA3	3.43e-05	4	55	2	CID013566747
Drug	2-(phosphonomethyl)phenylalanine	GLRA1 GLRA3	3.43e-05	4	55	2	CID000383689
Drug	SC-49648	GLRA1 GLRA3	3.43e-05	4	55	2	CID000195696
Drug	akuammiline	GLRA1 GLRA3	3.43e-05	4	55	2	CID005367018
Drug	NSC381080	GLRA1 GLRA3	3.43e-05	4	55	2	CID000165497
Drug	N-methyl-THIP	GLRA1 GLRA3	3.43e-05	4	55	2	CID000134373
Drug	SC-48981	GLRA1 GLRA3	3.43e-05	4	55	2	CID000126573
Drug	SC-50132	GLRA1 GLRA3	3.43e-05	4	55	2	CID000195719
Drug	SR 42641	GLRA1 GLRA3	3.43e-05	4	55	2	CID000129049
Drug	Glycine	SLC6A9 GLRA1 GLRA3	5.17e-05	30	55	3	DB00145
Drug	azetidine-3-carboxylic acid	GLRA1 GLRA3	5.70e-05	5	55	2	CID000093192
Drug	Lindane	GLRA1 GLRA3	5.70e-05	5	55	2	DB00431
Drug	Cao C	GLRA1 GLRA3	5.70e-05	5	55	2	CID000166617
Drug	oxanilide	GLRA1 GLRA3	5.70e-05	5	55	2	CID000069288
Drug	iso-THAO	GLRA1 GLRA3	5.70e-05	5	55	2	CID000127199
Drug	ALX1393	GLRA1 GLRA3	5.70e-05	5	55	2	CID016078939
Drug	pleiocarpamine	GLRA1 GLRA3	5.70e-05	5	55	2	CID000558637
Drug	mafoprazine	GLRA1 GLRA3	5.70e-05	5	55	2	CID000071241
Drug	gevotroline	GLRA1 GLRA3	5.70e-05	5	55	2	CID000060546
Drug	THAZ	GLRA1 GLRA3	8.54e-05	6	55	2	CID000171289
Drug	mV GABA	GLRA1 GLRA3	8.54e-05	6	55	2	CID000128435
Drug	caged glycine	GLRA1 GLRA3	8.54e-05	6	55	2	CID000192642
Drug	brometone	GLRA1 GLRA3	8.54e-05	6	55	2	CID000006424
Drug	minaxolone	GLRA1 GLRA3	8.54e-05	6	55	2	CID000071960
Drug	thiomuscimol	GLRA1 GLRA3	8.54e-05	6	55	2	CID000005448
Drug	thio-THIP	GLRA1 GLRA3	8.54e-05	6	55	2	CID000656720
Drug	AC1L90PQ	GLRA1 GLRA3	8.54e-05	6	55	2	CID000436036
Drug	pentoxifylline	CSN1S1 SMPD1 RELB PLD1 PLCH1 SNX13	9.02e-05	304	55	6	CID000004740
Drug	Lithocholic acid [434-13-9]; Up 200; 10.6uM; PC3; HT_HG-U133A	DOCK9 LAMA4 PLD1 DRC3 MEPE	1.05e-04	194	55	5	3816_UP
Drug	Clomiphene citrate (Z,E) [50-41-9]; Down 200; 6.6uM; HL60; HT_HG-U133A	LRRC42 SPTAN1 SMARCC2 RELB PLOD2	1.08e-04	195	55	5	1269_DN
Drug	Apomorphine hydrochloride hemihydrate [41372-20-7]; Down 200; 6.4uM; HL60; HG-U133A	SPTAN1 ZMYM2 SMARCC2 PLD1 SNX13	1.10e-04	196	55	5	2005_DN
Drug	Benzamil hydrochloride [2898-76-2]; Up 200; 11.2uM; PC3; HT_HG-U133A	ZMYM2 ZNF224 ALDH1L1 PLD1 SNX13	1.10e-04	196	55	5	4294_UP
Drug	Phentolamine hydrochloride [73-05-2]; Up 200; 12.6uM; PC3; HT_HG-U133A	LAMA4 ZMYM2 RELB PLCH1 SLC3A1	1.13e-04	197	55	5	4336_UP
Drug	Tiratricol, 3,3',5-triiodothyroacetic acid [51-24-1]; Down 200; 6.4uM; MCF7; HT_HG-U133A	DOCK9 GLRA1 TMEM209 PLCH1 SNX13	1.13e-04	197	55	5	2259_DN
Drug	Prednisone [53-03-2]; Down 200; 11.2uM; PC3; HT_HG-U133A	LAMA4 ZMYM2 RELB PLD1 PLCH1	1.13e-04	197	55	5	4577_DN
Drug	Nabumetone [42924-53-8]; Up 200; 17.6uM; MCF7; HT_HG-U133A	SLC6A9 GLRA1 LAMA4 RELB PLCH1	1.16e-04	198	55	5	6487_UP
Drug	haloperidol; Up 200; 10uM; PC3; HT_HG-U133A	TMEM209 LAMA4 RELB ZNF224 PLD1	1.16e-04	198	55	5	1203_UP
Drug	Cyclacillin [3485-14-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A	DOCK9 LAMA4 SMPD1 RELB ALDH1L1	1.16e-04	198	55	5	4358_UP
Drug	Ethisterone [434-03-7]; Up 200; 12.8uM; MCF7; HT_HG-U133A	SMPD1 RGS9 ALDH1L1 ANKRD7 DRC3	1.16e-04	198	55	5	3975_UP
Drug	Dosulepin hydrochloride [897-15-4]; Up 200; 12uM; MCF7; HT_HG-U133A	DOCK9 LAMA4 ALDH1L1 PLD1 SNX13	1.18e-04	199	55	5	5986_UP
Drug	Eucatropine hydrochloride [536-93-6]; Down 200; 12.2uM; HL60; HT_HG-U133A	SPTAN1 ZMYM2 RELB PLOD2 SLC3A1	1.18e-04	199	55	5	2556_DN
Drug	alpha-EMTBL	GLRA1 GLRA3	1.19e-04	7	55	2	CID000128423
Drug	CID189778	GLRA1 GLRA3	1.19e-04	7	55	2	CID000189778
Drug	propyl methanethiosulfonate	GLRA1 GLRA3	1.19e-04	7	55	2	CID000529387
Drug	thiocolchicoside	GLRA1 GLRA3	1.19e-04	7	55	2	CID000072067
Drug	L-serinamide	GLRA1 GLRA3	1.19e-04	7	55	2	CID000101138
Drug	Boc-glycine	GLRA1 GLRA3	1.19e-04	7	55	2	CID000078288
Drug	PK 8165	GLRA1 GLRA3	1.19e-04	7	55	2	CID000071219
Drug	betaine	RELB ALDH1L1 QARS1 PLOD2 SLC3A1	1.21e-04	200	55	5	CID000000247
Drug	Benzthiazide [91-33-8]; Up 200; 9.2uM; HL60; HT_HG-U133A	GLRA3 ALDH1L1 SLC3A1 SNX13 DRC3	1.21e-04	200	55	5	2989_UP
Drug	alpha-aminoisobutyric acid	GLRA1 GLRA3 SLC3A1	1.33e-04	41	55	3	CID000006119
Drug	isopropyl-beta-D-thioglucoside	KMT2C MTHFS PLCH1 QARS1	1.45e-04	110	55	4	CID000552632
Drug	WT702	GLRA1 GLRA3	1.59e-04	8	55	2	CID000089643
Drug	isostrychnine	GLRA1 GLRA3	1.59e-04	8	55	2	CID000264626
Drug	Atonik	GLRA1 GLRA3	2.04e-04	9	55	2	CID000069471
Drug	nortropanol	GLRA1 GLRA3	2.04e-04	9	55	2	CID000068147
Drug	AC1NSJX8	GLRA1 GLRA3	2.04e-04	9	55	2	CID005311059
Drug	NSC129536	GLRA1 GLRA3	2.04e-04	9	55	2	CID000004815
Drug	SR 57227A	GLRA1 GLRA3	2.04e-04	9	55	2	CID000131746
Drug	DCQX	GLRA1 GLRA3	2.04e-04	9	55	2	CID000001845
Drug	N-vinylcarbazole	IDO1 OPN1SW	2.04e-04	9	55	2	CID000015143
Drug	aspartate	AMPD2 GLRA1 GLRA3 ALDH1L1 QARS1 PLOD2 SLC3A1	2.39e-04	518	55	7	CID000000424
Drug	THBA	GLRA1 GLRA3	2.55e-04	10	55	2	CID000130993
Drug	5-nitro-2-(3-phenylpropylamino)benzoic acid	GLRA1 GLRA3 SMPD1	2.71e-04	52	55	3	CID000004549
Drug	8-bromoguanine	SMARCC2 SMARCAD1 MEPE	2.87e-04	53	55	3	CID000076473
Drug	tetrahydropteroylpentaglutamate	CSN1S1 ALDH1L1	3.11e-04	11	55	2	CID000193817
Drug	ip 0	GLRA1 GLRA3	3.11e-04	11	55	2	CID000006943
Disease	cranial vault morphology measurement	FRMPD4 LAMA4 EMC2	1.43e-03	121	54	3	EFO_0009278

Protein segments in the cluster

Peptide	Gene	Start	Entry
RQLMHSLFGDYRAQM	C8orf33	156	Q9H7E9
HNLVYRMRGDMQLFQ	SMPD1	556	P17405
NMAMLNHLRRQRGFH	AMPD2	666	Q01433
LCNLGAMRNLYAMHR	PTGDR	216	Q13258
MTIRHQGQQYRPRMA	RGS9	1	O75916
QASYRDQQGQMRRMD	RELB	271	Q01201
RFHLERQMGYYLIQM	GLRA3	246	O75311
PRYRFQSNHMDMVRI	MTHFS	81	P49914
AHLTNQYMQRVAGMR	PABPC4	376	Q13310
QYMQRVAGMRALPAN	PABPC4	381	Q13310
GHAAQFLQDMRRYMP	IDO1	286	P14902
NRGVYMFRMDNDHVI	KMT2C	4821	Q8NEZ4
EYGAALIRNNMQHIM	MEPE	141	Q9NQ76
AILDHQQFDYIIRMM	SBF2	601	Q86WG5
SREEYMNGMNRQRNI	CSN1S1	41	P47710
MEQGIRRDFMRNFIN	JRK	331	O75564
LDHMQAMRRYLLLGQ	TUBGCP3	556	Q96CW5
IYMRENGQLHMVNLA	LRRC42	16	Q9Y546
AAMAYNMNLLQTHGR	HELZ	1231	P42694
MGMANIHAIRNSFQY	MTMR4	341	Q9NYA4
NAREMGVFMYISNRH	PLOD2	496	O00469
RYIARTGMMHARLQQ	DOCK9	1351	Q9BZ29
MTANRDGRDYFINHM	FRMPD4	41	Q14CM0
QLRNMFISMVLLHRY	ANKRD7	226	Q92527
LNNRNMRALFGLYMS	EMC2	221	Q15006
HGRQQQMRRMEVYNE	DDX10	346	Q13206
NRIDNMMNIIYLRRF	DRC3	141	Q9H069
MRLFSGMNNQYTRRE	FAM240A	1	A0A1B0GVK7
ALQMNRRHRMPGYET	MAP3K3	16	Q99759
MFFRLEMRNGYLHVF	LAMA4	1096	Q16363
RGNHEDFMMNLRYGF	PPEF1	231	O14829
AAFAMYMVNNRNHGL	OPN1SW	266	P03999
QLLVERYHFNMGLLM	QARS1	136	P47897
RYHFNMGLLMGEARA	QARS1	141	P47897
FEMFQHNQLNRRMVY	SNX13	906	Q9Y5W8
GMFERAQERMQHQFQ	NUGGC	701	Q68CJ6
MGSIRYQHLMTINAN	SMARCAD1	636	Q9H4L7
GNALQAIMHFNYRTM	PLD1	836	Q13393
RFHLERQMGYYLIQM	GLRA1	241	P23415
QAMGVYITNFHVRMD	POLR2B	731	P30876
RLGNQYVNVMNMLLF	SLC3A1	456	Q07837
FGLQRMIFEVMQNNH	PHAF1	386	Q9BSU1
ESRRMLRGYNHQQMS	PHLDB2	951	Q86SQ0
MYARPRVIHAFNMNK	OR6B1	256	O95007
YAEMRARQQHFQQMH	SMARCC2	941	Q8TAQ2
GRLMYRLADLMEQHQ	ALDH1L1	486	O75891
AEVMRQRGINMRYLG	CLUH	776	O75153
MVDHYVSRVRGNLQM	REV3L	2516	O60673
NRDGHVSLQEYMAFM	SPTAN1	2381	Q13813
YGHRNYFQDIQMMLG	SLC6A9	551	P48067
GMLNAIQRFFAYHMI	TMEM168	446	Q9H0V1
ALNYQSEGRMMQLNR	PLCH1	681	Q4KWH8
RNNMFHTLLMFLYII	TMEM209	521	Q96SK2
HCFNRYRMANGLIMN	ZMYM2	451	Q9UBW7
QMERYQQHSMVFLGR	TPCN1	746	Q9ULQ1
YNRRLNLDMHQRVHM	ZNF224	661	Q9NZL3
YFRQLMINHENMPIF	ZNF461	161	Q8TAF7
QEIMRMFFNGRYILL	ATP6V0A2	441	Q9Y487