Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of nuclear pore

POM121 NUP58 POM121C POM121B

1.39e-0625674GO:0017056
GeneOntologyMolecularFunctionnuclear localization sequence binding

POM121 NUP58 POM121C POM121B

1.92e-0627674GO:0008139
GeneOntologyMolecularFunctionsignal sequence binding

POM121 NUP58 POM121C POM121B

2.57e-0551674GO:0005048
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

TBX3 CTBP1 TRIM24 SPEN CNOT1 MED13 DNMT1

4.87e-04417677GO:0061629
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

TBX3 CTBP1 TRIM24 SPEN CNOT1 MED13 DNMT1 TBX2

7.13e-04582678GO:0140297
GeneOntologyBiologicalProcessnuclear pore organization

POM121 POM121C POM121B

2.58e-0518673GO:0006999
GeneOntologyBiologicalProcessureteric peristalsis

TBX3 TBX2

3.11e-053672GO:0072105
GeneOntologyBiologicalProcessureter smooth muscle contraction

TBX3 TBX2

3.11e-053672GO:0014849
GeneOntologyBiologicalProcessmammary placode formation

TBX3 TBX2

6.21e-054672GO:0060596
GeneOntologyBiologicalProcessatrioventricular canal morphogenesis

TBX3 TBX2

1.03e-045672GO:1905222
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

CREBRF TBX3 GLIS2 PLAGL1 CTBP1 MACROH2A2 MAPK10 ASCL3 SPEN CNOT1 DNMT1 TBX2

1.31e-0410536712GO:0000122
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

CREBRF TBX3 GLIS2 PLAGL1 CTBP1 MACROH2A2 ZNF318 MAPK10 ASCL3 TRIM24 SPEN CNOT1 DNMT1 TBX2

1.33e-0413996714GO:0045892
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

CREBRF TBX3 GLIS2 PLAGL1 CTBP1 MACROH2A2 ZNF318 MAPK10 ASCL3 TRIM24 SPEN CNOT1 DNMT1 TBX2

1.48e-0414136714GO:1902679
GeneOntologyBiologicalProcessendocardial cushion formation

BMP5 TBX3 TBX2

1.52e-0432673GO:0003272
GeneOntologyBiologicalProcesscardiac jelly development

TBX3 TBX2

1.55e-046672GO:1905072
DomainTBX

TBX3 TBX2

1.08e-052622IPR022582
DomainTBX

TBX3 TBX2

1.08e-052622PF12598
DomainLa

LARP4B LARP4

2.25e-047622PF05383
DomainLA

LARP4B LARP4

2.25e-047622SM00715
DomainLupus_La_RNA-bd

LARP4B LARP4

2.25e-047622IPR006630
DomainHTH_LA

LARP4B LARP4

2.25e-047622PS50961
DomainTF_T-box

TBX3 TBX2

1.43e-0317622IPR001699
DomainTBOX

TBX3 TBX2

1.43e-0317622SM00425
DomainTF_T-box_CS

TBX3 TBX2

1.43e-0317622IPR018186
Domain-

TBX3 TBX2

1.43e-03176222.60.40.820
DomainTBOX_3

TBX3 TBX2

1.43e-0317622PS50252
DomainT-box

TBX3 TBX2

1.43e-0317622PF00907
DomainTBOX_1

TBX3 TBX2

1.43e-0317622PS01283
DomainTBOX_2

TBX3 TBX2

1.43e-0317622PS01264
DomainBromodomain_CS

CECR2 TRIM24

3.35e-0326622IPR018359
DomainBROMODOMAIN_1

CECR2 TRIM24

6.70e-0337622PS00633
DomainBromodomain

CECR2 TRIM24

7.06e-0338622PF00439
Domain-

HHIP ROS1

7.42e-03396222.120.10.30
DomainBROMODOMAIN_2

CECR2 TRIM24

8.18e-0341622PS50014
DomainBROMO

CECR2 TRIM24

8.57e-0342622SM00297
DomainBromodomain

CECR2 TRIM24

8.57e-0342622IPR001487
Domain-

CECR2 TRIM24

8.57e-03426221.20.920.10
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

POM121 NUP58 POM121C POM121B

1.16e-0540504MM14945
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

POM121 NUP58 POM121C POM121B

1.29e-0541504MM15200
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

POM121 NUP58 POM121C POM121B

1.42e-0542504MM15039
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

POM121 NUP58 POM121C POM121B

1.56e-0543504MM14609
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

POM121 NUP58 POM121C POM121B

2.23e-0547504MM14939
PathwayREACTOME_GENE_SILENCING_BY_RNA

POM121 NUP58 POM121C POM121B

2.64e-0549504MM14837
PathwayREACTOME_SUMOYLATION

POM121 CTBP1 NUP58 POM121C POM121B DNMT1

2.79e-05169506MM14919
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

POM121 NUP58 POM121C POM121B

2.86e-0550504MM14610
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

POM121 NUP58 POM121C POM121B

3.09e-0551504MM15151
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

POM121 NUP58 POM121C POM121B

4.18e-0555504MM14917
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

POM121 NUP58 POM121C POM121B

5.16e-0558504MM15149
PathwayREACTOME_SNRNP_ASSEMBLY

POM121 NUP58 POM121C POM121B

5.16e-0558504MM14736
PathwayREACTOME_POSTMITOTIC_NUCLEAR_PORE_COMPLEX_NPC_REFORMATION

POM121 POM121C POM121B

8.06e-0524503MM15658
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

POM121 NUP58 POM121C POM121B

8.08e-0565504MM15147
PathwayREACTOME_CREB3_FACTORS_ACTIVATE_GENES

CREBRF CREB3L3

1.22e-045502MM15513
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

POM121 NUP58 POM121C POM121B

1.27e-0473504MM14948
PathwayREACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN

POM121 NUP58 POM121C

1.94e-0432503M29579
PathwayREACTOME_GLUCOSE_METABOLISM

POM121 NUP58 POM121C POM121B

2.00e-0482504MM15394
PathwayREACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS

POM121 NUP58 POM121C

2.13e-0433503M27016
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

POM121 NUP58 POM121C POM121B

2.19e-0484504MM14929
PathwayREACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN

POM121 NUP58 POM121C

2.33e-0434503M27041
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

POM121 NUP58 POM121C POM121B

2.40e-0486504MM15413
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

POM121 NUP58 POM121C

2.54e-0435503M27320
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

POM121 NUP58 POM121C

2.76e-0436503M27245
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

POM121 NUP58 POM121C

2.76e-0436503M26974
PathwayREACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS

POM121 NUP58 POM121C

3.00e-0437503M1029
PathwayREACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS

POM121 NUP58 POM121C

3.00e-0437503M27038
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

POM121 NUP58 POM121C POM121B

3.11e-0492504MM14951
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

POM121 NUP58 POM121C

3.51e-0439503M27238
PathwayREACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS

POM121 NUP58 POM121C

4.07e-0441503M29574
PathwayREACTOME_CREB3_FACTORS_ACTIVATE_GENES

CREBRF CREB3L3

4.37e-049502M27773
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

POM121 NUP58 POM121C

4.69e-0443503M26975
PathwayREACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS

POM121 NUP58 POM121C

5.02e-0444503M109
PathwayREACTOME_SUMOYLATION

POM121 CTBP1 NUP58 POM121C DNMT1

5.34e-04189505M27214
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

POM121 NUP58 POM121C

5.72e-0446503M27397
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

POM121 NUP58 POM121C

6.10e-0447503M27395
PathwayREACTOME_MITOTIC_PROPHASE

POM121 NUP58 POM121C POM121B

7.01e-04114504MM15361
PathwayREACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR

CREBRF CREB3L3

7.95e-0412502MM14981
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

POM121 NUP58 POM121C

8.68e-0453503M27212
PathwayREACTOME_SNRNP_ASSEMBLY

POM121 NUP58 POM121C

9.17e-0454503M29594
PathwayREACTOME_TRNA_PROCESSING_IN_THE_NUCLEUS

POM121 NUP58 POM121C

1.19e-0359503M27606
PathwayREACTOME_MITOTIC_METAPHASE_AND_ANAPHASE

POM121 NDEL1 ESPL1 POM121C POM121B

1.39e-03234505MM14898
PathwayREACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC

MUC16 MUC4

1.43e-0316502M27410
PathwayREACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS

MUC16 MUC4

1.62e-0317502M27412
PathwayREACTOME_NUCLEAR_ENVELOPE_NE_REASSEMBLY

POM121 POM121C POM121B

1.79e-0368503MM14921
PathwayREACTOME_COPII_MEDIATED_VESICLE_TRANSPORT

LMAN1 SEC23IP GRIA1

1.87e-0369503M27113
PathwayREACTOME_CELLULAR_RESPONSES_TO_STIMULI

CREBRF POM121 NUP58 CREB3L3 MAPK10 POM121C POM121B

1.91e-03505507MM15548
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

POM121 NUP58 POM121C

2.03e-0371503M27394
PathwayREACTOME_ISG15_ANTIVIRAL_MECHANISM

POM121 NUP58 POM121C

2.28e-0374503M48006
PathwayREACTOME_M_PHASE

POM121 NDEL1 NUP58 ESPL1 POM121C POM121B

2.36e-03387506MM15364
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_ADDITIONAL_CELL_CYCLE_GENES_WHOSE_EXACT_ROLE_IN_THE_P53_PATHWAY_REMAIN_UNCERTAIN

PLAGL1 CNOT1

2.48e-0321502M27634
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC16 MUC4

2.48e-0321502MM15706
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

POM121 NUP58 POM121C

2.55e-0377503M27226
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC16 MUC4

2.97e-0323502M556
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

POM121 NUP58 POM121C

3.05e-0382503M27250
PathwayREACTOME_COPII_MEDIATED_VESICLE_TRANSPORT

LMAN1 SEC23IP GRIA1

3.16e-0383503MM14819
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

POM121 NUP58 POM121C

3.27e-0384503M725
PathwayREACTOME_GLUCOSE_METABOLISM

POM121 NUP58 POM121C

3.38e-0385503M1870
PathwayREACTOME_DECTIN_2_FAMILY

MUC16 MUC4

3.79e-0326502M27483
PathwayREACTOME_POSTMITOTIC_NUCLEAR_PORE_COMPLEX_NPC_REFORMATION

POM121 NUP58

4.09e-0327502M29807
Pubmed

POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation.

POM121 POM121C POM121B

7.15e-09368330802453
Pubmed

Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.

POM121 POM121C POM121B

7.15e-09368335507432
Pubmed

Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes.

POM121 POM121C POM121B

2.86e-08468317900573
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

POM121 NUP58 POM121C POM121B

9.38e-073868412791264
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

POM121 SEC23IP NUP58 ANKHD1 LARP4 POM121C TRIM24 CNOT1

3.10e-0645768832344865
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

POM121 POM121C POM121B

3.20e-061568314697343
Pubmed

The T-box transcription factors TBX2 and TBX3 in mammary gland development and breast cancer.

TBX3 TBX2

3.77e-06268223624936
Pubmed

Stratification based on methylation of TBX2 and TBX3 into three molecular grades predicts progression in patients with pTa-bladder cancer.

TBX3 TBX2

3.77e-06268225394776
Pubmed

Complex functional redundancy of Tbx2 and Tbx3 in mouse limb development.

TBX3 TBX2

3.77e-06268235506352
Pubmed

The transcription factors TBX2 and TBX3 interact with human papillomavirus 16 (HPV16) L2 and repress the long control region of HPVs.

TBX3 TBX2

3.77e-06268223388722
Pubmed

Identification of TBX2 and TBX3 variants in patients with conotruncal heart defects by target sequencing.

TBX3 TBX2

3.77e-06268230223900
Pubmed

Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome.

TBX3 TBX2

3.77e-06268210468588
Pubmed

Immunocytochemistry for MUC4 and MUC16 is a useful adjunct in the diagnosis of pancreatic adenocarcinoma on fine-needle aspiration cytology.

MUC16 MUC4

3.77e-06268223544943
Pubmed

The anti-proliferative function of the TGF-β1 signaling pathway involves the repression of the oncogenic TBX2 by its homologue TBX3.

TBX3 TBX2

3.77e-06268225371204
Pubmed

Interaction network of human early embryonic transcription factors.

TBX3 CTBP1 NUP58 POM121C TRIM24 SPEN TBX2

5.74e-0635168738297188
Pubmed

T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis.

BMP5 TBX3 TBX2

1.07e-052268315843407
Pubmed

Microbial products alter the expression of membrane-associated mucin and antimicrobial peptides in a three-dimensional human endocervical epithelial cell model.

MUC16 MUC4

1.13e-05368223053434
Pubmed

T-box family reunion.

TBX3 TBX2

1.13e-0536829196325
Pubmed

LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation.

LARP4B LARP4

1.13e-05368226001795
Pubmed

Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas.

MUC16 MUC4

1.13e-05368230236127
Pubmed

Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family.

TBX3 TBX2

1.13e-0536828988164
Pubmed

Regulation of membrane-associated mucins in the human corneal epithelial cells by dexamethasone.

MUC16 MUC4

1.13e-05368217592322
Pubmed

Expression of Drosophila omb-related T-box genes in the developing human and mouse neural retina.

TBX3 TBX2

1.13e-05368211726608
Pubmed

Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes.

TBX3 TBX2

1.13e-05368220025935
Pubmed

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.

MUC16 MUC4

1.13e-05368235879412
Pubmed

Krüppel-like zinc finger protein Gli-similar 2 (Glis2) represses transcription through interaction with C-terminal binding protein 1 (CtBP1).

GLIS2 CTBP1

1.13e-05368216326862
Pubmed

The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator.

TBX3 TBX2

1.13e-05368212000749
Pubmed

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.

TBX3 TBX2

1.13e-05368211748239
Pubmed

Functional Consequences of Differential O-glycosylation of MUC1, MUC4, and MUC16 (Downstream Effects on Signaling).

MUC16 MUC4

1.13e-05368227483328
Pubmed

MicroRNA-200c modulates the expression of MUC4 and MUC16 by directly targeting their coding sequences in human pancreatic cancer.

MUC16 MUC4

1.13e-05368224204560
Pubmed

Expression of the transmembrane mucins, MUC1, MUC4 and MUC16, in normal endometrium and in endometriosis.

MUC16 MUC4

1.13e-05368224939955
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

LARP4B POM121 LMAN1 BAIAP2L1 INF2 ADAM15 SEC23IP ESPL1 POM121C DNMT1

1.42e-05942681031073040
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

LMAN1 SEC23IP CTBP1 ZNF318 ANKHD1 TRIM24 CNOT1

1.78e-0541868734709266
Pubmed

Tbx3 represses E-cadherin expression and enhances melanoma invasiveness.

TBX3 TBX2

2.25e-05468218829543
Pubmed

Genome-wide analysis of CpG island methylation in bladder cancer identified TBX2, TBX3, GATA2, and ZIC4 as pTa-specific prognostic markers.

TBX3 TBX2

2.25e-05468222284968
Pubmed

Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity.

TBX3 TBX2

2.25e-0546828798150
Pubmed

TRPV4 activation in human corneal epithelial cells promotes membrane mucin production.

MUC16 MUC4

2.25e-05468239024979
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

LARP4B NF1 POM121 ZNF318 LARP4 ESPL1 POM121C

2.47e-0544068734244565
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

NF1 SEC23IP MUC16 MACROH2A2 POM121C TRIM24 SPEN CNOT1

3.45e-0563868831182584
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

LARP4B CECR2 CTBP1 SPEN MUC4 CNOT1 DNMT1

3.70e-0546968727634302
Pubmed

Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development.

TBX3 TBX2

3.75e-0556828853987
Pubmed

The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup.

TBX3 TBX2

3.75e-05568217173667
Pubmed

Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence.

TBX3 TBX2

3.75e-05568222002537
Pubmed

Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis.

TBX3 TBX2

3.75e-0556821375456
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

LARP4B NF1 ZNF318 ANKHD1 LARP4 SPEN CNOT1 DNMT1

4.06e-0565368822586326
Pubmed

Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s).

POM121 POM121C POM121B

4.47e-053568311013070
Pubmed

A human MAP kinase interactome.

TBX3 POM121 NDEL1 ERRFI1 NUP58 MAPK10 POM121C

4.63e-0548668720936779
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

LARP4B INF2 MACROH2A2 NUP58 POM121C CNOT1

4.81e-0533268625693804
Pubmed

The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.

SPATA31A1 SPATA31A6

5.62e-05668220850414
Pubmed

Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway.

TBX3 TBX2

5.62e-05668216222716
Pubmed

Reduced sodium channel function unmasks residual embryonic slow conduction in the adult right ventricular outflow tract.

TBX3 TBX2

5.62e-05668223661717
Pubmed

Lack of genetic interaction between Tbx20 and Tbx3 in early mouse heart development.

TBX3 TBX2

5.62e-05668223936153
Pubmed

Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud.

TBX3 TBX2

5.62e-05668218410737
Pubmed

RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes.

CTBP1 SPEN

5.62e-05668216287852
Pubmed

Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.

SPATA31A1 SPATA31A6

5.62e-05668225930072
Pubmed

Evolution of mouse T-box genes by tandem duplication and cluster dispersion.

TBX3 TBX2

5.62e-0566828878690
Pubmed

RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes.

CTBP1 DNMT1

5.62e-05668217972916
Pubmed

Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.

POM121 POM121C POM121B

5.74e-053868311779826
Pubmed

Myocardial β-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation.

BMP5 TBX3 TBX2

5.74e-053868330201295
Pubmed

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

LARP4B ANKHD1 LARP4 CNOT1

5.93e-0510768430995489
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

TBX3 LARP4B CECR2 MACROH2A2 ZNF318 GPR108 ANKHD1 POM121C TRIM24 TBX2

5.97e-051116681031753913
Pubmed

Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis.

TBX3 TBX2

7.86e-05768222203979
Pubmed

Expression of Tbx2 and Tbx3 in the developing hypothalamic-pituitary axis.

TBX3 TBX2

7.86e-05768218534921
Pubmed

Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field.

TBX3 TBX2

7.86e-05768216556915
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

LARP4B PROSER3 ADAM15 SEC23IP GPR108 LARP4 ESPL1 DNMT1

9.09e-0573368834672954
Pubmed

Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.

LARP4B LMAN1 INF2 TNFRSF11A LARP4 CNOT1

9.41e-0537568632788342
Pubmed

A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members if the T-box family.

TBX3 TBX2

1.05e-0486829503012
Pubmed

Ihh and Runx2/Runx3 signaling interact to coordinate early chondrogenesis: a mouse model.

BMP5 HHIP

1.05e-04868223383321
Pubmed

An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus.

TBX3 TBX2

1.05e-0486827920656
Pubmed

Maternally expressed NLRP2 links the subcortical maternal complex (SCMC) to fertility, embryogenesis and epigenetic reprogramming.

PLAGL1 DNMT1

1.05e-04868228317850
Pubmed

Dynamic expression of Tbx2 and Tbx3 in developing mouse pancreas.

TBX3 TBX2

1.05e-04868221867776
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SLC7A3 NF1 PRR36 SEC23IP GRIA1 CTBP1 ZNF318 CNOT1 DNMT1

1.05e-0496368928671696
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

PRAM1 CECR2 VRTN MUC16 TRIM24 SPEN

1.27e-0439668626687479
Pubmed

Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43.

TBX3 TBX2

1.68e-041068218285513
Pubmed

MyoR modulates cardiac conduction by repressing Gata4.

TBX3 TBX2

1.68e-041068225487574
Pubmed

Transcription is required for establishment of germline methylation marks at imprinted genes.

ADRA1B PLAGL1

1.68e-041068219136628
Pubmed

Dynamic expression of Tbx2 subfamily genes in development of the mouse reproductive system.

TBX3 TBX2

1.68e-041068222223620
Pubmed

Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis.

TBX3 TBX2

1.68e-041068217519333
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

POM121 SEC23IP ZNF318 POM121C CNOT1

1.68e-0426368534702444
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

TBX3 GLIS2 ZNF318 CREB3L3 ZNF844 TRIM24 MBNL3 DNMT1

1.77e-0480868820412781
Pubmed

Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy.

TBX3 TBX2

2.05e-041168217668378
Pubmed

Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation at gastrulation.

TBX3 TBX2

2.05e-04116828954725
Pubmed

Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling.

TBX3 TBX2

2.05e-041168214723846
Pubmed

Genetic mapping and evaluation of candidate genes for spasmodic, a neurological mouse mutation with abnormal startle response.

ADRA1B GRIA1

2.05e-04116828406478
Pubmed

Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4.

GRIA1 AP4B1

2.05e-041168218341993
Pubmed

Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.

TRIM24 CNOT1 MED13

2.15e-045968328813667
Pubmed

The molecular basis of Pallister Hall associated polydactyly.

TBX3 TBX2

2.45e-041268217588959
Pubmed

Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1.

INF2 MBNL3

2.45e-041268237143315
Pubmed

ISL1 regulates lung branching morphogenesis via Shh signaling pathway.

TBX3 TBX2

2.45e-041268237442233
Pubmed

SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer.

INF2 TRIM24

2.45e-041268231911863
Pubmed

VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.

BAIAP2L1 INF2 NUP58 ANKHD1 ESPL1

2.56e-0428868523383273
Pubmed

Expression of Slit and Robo genes in the developing mouse heart.

TBX3 TBX2

2.90e-041368220941780
Pubmed

Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome.

TBX3 TBX2

2.90e-041368212668638
Pubmed

Canonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties.

TBX3 TBX2

2.90e-041368225599332
Pubmed

Loss of Tbx2 delays optic vesicle invagination leading to small optic cups.

TBX3 TBX2

3.38e-041468219576202
Pubmed

Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system.

TBX3 TBX2

3.38e-041468218467625
Pubmed

HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme.

TBX3 TBX2

3.89e-041568225453830
Pubmed

Twist1 activity thresholds define multiple functions in limb development.

TBX3 TBX2

3.89e-041568220732316
Pubmed

The sacral autonomic outflow is sympathetic.

TBX3 TBX2

4.44e-041668227856909
Pubmed

Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development.

TBX3 TBX2

4.44e-041668227253890
Cytoband19p13.2

PRAM1 PRR36 MUC16 ZNF844 DNMT1 CCDC159

1.22e-0622968619p13.2
CytobandEnsembl 112 genes in cytogenetic band chr19p13

PRAM1 PRR36 MUC16 CREB3L3 GPR108 ZNF844 DNMT1 CCDC159

2.35e-05797688chr19p13
Cytoband7q11.23

POM121 POM121C POM121B

4.15e-04976837q11.23
Cytoband3p22.1

ZNF619 ZNF662

1.63e-03406823p22.1
Cytoband1p36

ERRFI1 SPEN

2.24e-03476821p36
GeneFamilyLa ribonucleoprotein domain containing|RNA binding motif containing

LARP4B LARP4

1.10e-047422625
GeneFamilyT-boxes

TBX3 TBX2

7.87e-0418422766
GeneFamilyCD molecules|Mucins

MUC16 MUC4

1.08e-0321422648
GeneFamilyNucleoporins

POM121 NUP58

2.50e-03324221051
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

GLIS2 PLAGL1 ZNF318 ZNF619 ZNF844 ZNF662

5.95e-0371842628
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHIP BAIAP2L1 CECR2 ERRFI1 ROS1 TRIM24

4.07e-07186686e83718fabb057100835d3357df407f283d23fe16
ToppCell(6)_Endothelial_cells-(6)_Endothelial-C_(Capillary_Aerocyte_)|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

TBX3 CYP3A7 PLAGL1 MAPK10 TBX2

4.24e-0615768584f629b7f589ca8a1abc220fa740c4a6fdc1b579
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHIP BAIAP2L1 CECR2 ERRFI1 TRIM24

8.02e-06179685fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCellControl-Epithelial_cells-Airway_mucous|Control / group, cell type (main and fine annotations)

BAIAP2L1 INF2 MUC16 XDH MUC4

8.93e-0618368515d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHIP BAIAP2L1 CECR2 ERRFI1 ROS1

9.17e-06184685ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP5 ERRFI1 GRIA1 MACROH2A2 TBX2

1.04e-0518968532e6d6285b258831b965281224ff2aaeecdcb5f5
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP5 ERRFI1 GRIA1 MACROH2A2 TBX2

1.04e-05189685385ef7bbd76c8047aeecf6542377d4213b5da5db
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

HHIP CECR2 ERRFI1 ROS1 MAPK10

1.10e-0519168534cc997e4e5c727495f321e6807a84aa124da486
ToppCellhuman_hepatoblastoma-Tumor_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

TBX3 ERRFI1 TRIM24 MED13 MBNL3

1.15e-05193685503a979328c68b096680b71359a26f02fafdff35
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / Treatment groups by lineage, cell group, cell type

HHIP LMAN1 BAIAP2L1 ERRFI1 TRIM24

1.27e-051976851a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCellCOVID-19-Epithelial|COVID-19 / Condition, Lineage and Cell class

BAIAP2L1 MUC16 MAPK10 MUC4 CFAP65

1.27e-0519768518fd7344628a87d5c7ef5efb66e260a4136245bf
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BMP5 TBX3 HHIP MACROH2A2 TBX2

1.31e-05198685148f5fee19ea8dff7f2de4ca69c3b03e5221985d
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

HHIP CECR2 ERRFI1 ROS1 TRIM24

1.37e-05200685e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCellcritical-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

MCMBP ADAM15 NUP58 RFWD3 DNMT1

1.37e-05200685f39db4250ce220a3eb58edee3f7fc3671701d46f
ToppCellParenchymal-10x5prime-Epithelial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

HHIP BAIAP2L1 ERRFI1 ROS1 MUC4

1.37e-052006854e5b6cb014d9bcb58e13c7511c86c43e27c496e4
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BAIAP2L1 CECR2 ERRFI1 TRIM24

4.70e-051306846434d9106ccb38786dad36fab80163dfc07b6eb7
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TBX3 PLAGL1 MAPK10 TBX2

6.09e-051396842fdc8f36510aff24abbc79ef2a842db75a85f946
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TBX3 PLAGL1 MAPK10 TBX2

6.09e-051396845970a654c64e3b54f9d18c102f5b125eec892fc5
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GP6 XDH MACROH2A2 LARP4

6.80e-051436848f897278f9ccc82ae35e4f30c5f930b2a3eb509d
ToppCell356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TBX3 PLAGL1 TBX2

7.75e-055468368c762094ea29e321a6fd4f6d9b598431023fa7b
ToppCell356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TBX3 PLAGL1 TBX2

7.75e-05546837816e6541e3a9e702f25bd102a95ce963ce31535
ToppCellLPS-antiTNF-Stromal_mesenchymal-Fibroblasts-Monocytes-Macrophages|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CYP3A7 SFXN5 CTBP1 MBNL3

8.40e-05151684f13a117ae26ae525da4f3e837d8f204d00dc6ee3
ToppCellfacs-Marrow-T-cells-24m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GP6 PRAM1 SFXN5 XDH

8.40e-05151684ced4f7ee377a23a804ae6fde624e8b55b79f1fd8
ToppCellfacs-Marrow-T-cells-24m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GP6 PRAM1 SFXN5 XDH

8.40e-05151684b52bb3b88e9a6473f571053537b8beb418678539
ToppCell356C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

BMP5 CYP3A7 GRIA1 TBX2

1.05e-041606840293b244c063a62819690bf22bbc2681f8d15252
ToppCell356C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

BMP5 CYP3A7 GRIA1 TBX2

1.05e-041606843eaae86fa08f7651021316f8e5811bf48055591e
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Basal_1|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

PROSER3 GRIA1 MACROH2A2 MAPK10

1.33e-04170684aabe993c9f337b1caaeb0e64626a3920579c41b7
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.C1ql3_(VTA_(dorsal_VTA))-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

VRTN CREB3L3 STKLD1

1.35e-04656834382d56d5f71c7acfe35f84db7257aba2a7dd36a
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.C1ql3_(VTA_(dorsal_VTA))|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

VRTN CREB3L3 STKLD1

1.35e-046568305b712f83d88e864747cd0229a39aca17321e0f8
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HHIP GLIS2 MUC16 PLAGL1

1.45e-041746844da79da7a09ee1e345102c5331675ebcdbe56171
ToppCell5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BMP5 HHIP STARD9 MAPK10

1.55e-04177684e65c0568dc5852108e9802273499bc7cf88fafab
ToppCell390C-Fibroblasts-Fibroblast-G|390C / Donor, Lineage, Cell class and subclass (all cells)

BMP5 TBX3 CYP3A7 GRIA1

1.65e-04180684137fc14859c89e1ecd98bee388bb58c04b835847
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

HHIP CECR2 ROS1 MAPK10

1.65e-04180684198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell390C-Fibroblasts-Fibroblast-G-|390C / Donor, Lineage, Cell class and subclass (all cells)

BMP5 TBX3 CYP3A7 GRIA1

1.65e-04180684cd6790de050151fedfa2c5ea6ad58b72665414b2
ToppCellfacs-Heart-LV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP5 TBC1D30 ERRFI1 TBX2

1.69e-041816841db1eb7d330a7e5090994007ae287e11f0a74450
ToppCellfacs-Heart-LV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP5 TBC1D30 ERRFI1 TBX2

1.69e-0418168406174ce9240c9261c0f51a1b0d875335d60722e5
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHIP BAIAP2L1 ERRFI1 ROS1

1.72e-0418268417ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

HHIP CECR2 ROS1 MAPK10

1.76e-041836846847c1252d6bb105524f812658112517fd351eab
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TBX3 SPATA31A1 PRR36 TBX2

1.80e-041846847712f2e1fae5cdde2d4e355b860dc8536b28e4f6
ToppCellControl-Epithelial_cells-Airway_goblet|Control / group, cell type (main and fine annotations)

BAIAP2L1 MUC16 XDH MUC4

1.80e-04184684d92a71441e4e19f8c301999d8186f8e48e3cd162
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Adult / Lineage, Cell type, age group and donor

ADRA1B CECR2 MAPK10 MUC4

1.83e-04185684673f0c688ae6984bc8027df2da335787924f4137
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHIP CECR2 ERRFI1 TRIM24

1.83e-041856840d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

BAIAP2L1 ROS1 MAPK10 MUC4

1.83e-04185684cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHIP BAIAP2L1 CECR2 ERRFI1

1.83e-04185684fefaf227d89f680d6f3e91c4a94e26ab4d0dc6c3
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-AT2_Progenitor|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHIP BAIAP2L1 CECR2 ERRFI1

1.83e-04185684929b68b05b7686341329ac756d7df172cb4b810b
ToppCelldroplet-Lung-nan-18m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP5 HHIP ERRFI1 PLAGL1

1.87e-04186684b58db5abdd3e9f0214b198c3cbd09b0b3c321eab
ToppCelldroplet-Lung-nan-18m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP5 HHIP ERRFI1 PLAGL1

1.87e-04186684cd6502bbf9dce318fdbb4965d49df8951e5f795c
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP5 HHIP SLC10A1

1.90e-04736833ac392ac46ad577c7d2c2b5e6a0a96ceb613097b
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP5 HHIP SLC10A1

1.90e-04736831bd6ff9659efc43b0a596da50e325bde2f0ba8f7
ToppCellLPS-antiTNF-Epithelial_alveolar|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHIP BAIAP2L1 CECR2 ERRFI1

1.91e-04187684201ff693e4756ee3e44762885b3a303a77eb535b
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

BMP5 ADRA1B GRIA1 TBX2

1.91e-0418768492d468dde81125d51daf7abd4703741abe1ab91c
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|368C / Donor, Lineage, Cell class and subclass (all cells)

TBC1D30 ROS1 MACROH2A2 CCDC159

1.91e-04187684b827d9da7032bf051756ddf88352af922eb0f87b
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|368C / Donor, Lineage, Cell class and subclass (all cells)

TBC1D30 ROS1 MACROH2A2 CCDC159

1.91e-0418768461c00604dda8b36a5c3eea6554e5601aa1b884f7
ToppCellLPS-IL1RA-Epithelial_alveolar|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHIP BAIAP2L1 CECR2 ERRFI1

1.95e-041886846164d467b612767ceba15de34176bcc8e8c36ab8
ToppCellLAM-Endothelial-VasEndo-1|Endothelial / Condition, Lineage and Cell class

TBX3 GLIS2 PLAGL1 TBX2

1.95e-04188684f24c33d960ca93459584a79ff8f0ec20db6a34d5
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

BAIAP2L1 ROS1 MAPK10 MUC4

1.95e-04188684c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHIP BAIAP2L1 CECR2 ERRFI1

1.95e-041886844bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCellE12.5-Mesenchymal|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TBX3 PLAGL1 MACROH2A2 TBX2

1.95e-041886849778dadc2bd7ded3a723e717d1c8cd3160e99c6c
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

BAIAP2L1 ERRFI1 ROS1 MAPK10

1.95e-04188684707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D231|Adult / Lineage, Cell type, age group and donor

HHIP CECR2 ROS1 MAPK10

1.99e-04189684dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor-cycling_neuroblast|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TBX3 PRR36 MAPK10 TBX2

1.99e-04189684815afad947ed77a8b03724bf78014799fed34f54
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BMP5 TBX3 MACROH2A2 TBX2

1.99e-041896843169476f98b7385706cb618c9ad64ae83a290ef0
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2|Children_(3_yrs) / Lineage, Cell type, age group and donor

HHIP CECR2 ROS1 MAPK10

2.07e-04191684a0332a4ef629510fb313ec119195c44a3f704a80
ToppCellChildren_(3_yrs)-Epithelial-club_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADRA1B XDH MAPK10 MUC4

2.07e-0419168423776c7302cead3881b39127398f3b3e0d27885e
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

TBX3 PLAGL1 TRIM24 MED13

2.11e-04192684916fbec1c7ab7969bda711886ac88e877e30c280
ToppCellEpithelial-alveolar_epithelial_cell_type_2|World / Lineage, Cell type, age group and donor

HHIP CECR2 ROS1 MAPK10

2.11e-0419268458c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

HHIP ERRFI1 ROS1 MAPK10

2.11e-04192684cc9911e182a289779a2612bc213daae5607689e7
ToppCellCOPD-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

MUC16 MAPK10 MUC4 CFAP65

2.11e-04192684eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

HHIP CECR2 ROS1 MAPK10

2.16e-04193684fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRR36 MACROH2A2 ESPL1 ASCL3

2.16e-041936845879efb38e6b3bf8c33c9a773632b1d726e3c153
ToppCellILEUM-inflamed-(8)_Smooth_muscle_cells|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

BMP5 TBX3 HHIP MAPK10

2.16e-04193684084c88f08ce0ecd6c9f4334caed370eb2154f896
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2|Adult / Lineage, Cell type, age group and donor

HHIP CECR2 ROS1 MAPK10

2.16e-04193684738f4f0a9ddde2432b429ab46838e353b1790589
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree-Tuft|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRR36 MACROH2A2 ESPL1 ASCL3

2.16e-04193684725115a5ce3ef520b3ef469e96b8219b4c723fdd
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree-Tuft-Tuft_L.0.7.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRR36 MACROH2A2 ESPL1 ASCL3

2.16e-04193684abd7bcf318a2d895d8811c2ada8bfb4314fca3b1
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

TBX3 PLAGL1 TRIM24 MED13

2.16e-04193684e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

HHIP CECR2 ROS1 MAPK10

2.16e-04193684f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCellTCGA-Adrenal-Primary_Tumor-Adrenocortical_carcinoma|TCGA-Adrenal / Sample_Type by Project: Shred V9

TBX3 BAIAP2L1 PLAGL1 TRIM24

2.16e-04193684c0d4da15d973cf6f8daa2b0af84b1baaf8491b83
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TBX3 MACROH2A2 DNMT1 TBX2

2.20e-04194684af4bbb2deb5a3913eb58990690fc3c62fbc3708c
ToppCellP15-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

BMP5 HHIP ERRFI1 PLAGL1

2.20e-041946845f04d21c4e2d36e74b6c5889aa97fd98f75a0973
ToppCellCOVID-19-Epithelial-Ciliated_cells|COVID-19 / Condition, Lineage and Cell class

MUC16 MAPK10 MUC4 CFAP65

2.20e-0419468443be5fbd51dd58839cb03ca3ddd05a458e1ddb74
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 MAPK10 MUC4 CFAP65

2.24e-0419568479dc031258579ea328181dda33710dd897f1064a
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HHIP CECR2 ROS1 NUP58

2.29e-041966847e5addaa844e66f8160e05858c341866a80aed23
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

BMP5 PLAGL1 MACROH2A2 TBX2

2.29e-04196684028a06ed92f1c058dcbeacd335625bf529e87a7b
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BMP5 HHIP ADRA1B TBX2

2.29e-041966842a885eed52f9b002c7995e11e450c7e8d7ae69e6
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BMP5 HHIP ADRA1B TBX2

2.29e-0419668414246f00c90741a5f8683f377e22e3a7c99661b9
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TBX3 GRIA1 MAPK10 TBX2

2.33e-041976840dd71e399f253787fa546a7e90c5373180b89ffd
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BMP5 TBX3 HHIP MUC4

2.33e-041976841da8ba5bbab232add6e43ad78b15c2339d0c2bc3
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

HHIP LMAN1 ROS1 TRIM24

2.33e-041976841485933986921ff45669d9b7501c8d17050b3e97
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HHIP CECR2 ROS1 NUP58

2.33e-04197684bf10727fbe90b71d2ac60a11711e5f0701b3799d
ToppCellLPS_only-Epithelial_alveolar-AT_2|LPS_only / Treatment groups by lineage, cell group, cell type

HHIP LMAN1 ERRFI1 TRIM24

2.38e-04198684d087e738d69ca9853553fde46d4e7a8906439d32
ToppCellBAL-Severe-Epithelial-Epithelial-AT1/AT2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HHIP BAIAP2L1 ERRFI1 ROS1

2.38e-04198684691a2f1779225e5519155460eeb6a2aac5f67a92
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

HHIP LMAN1 CECR2 ERRFI1

2.38e-04198684285f729140b1df029c24f6ca1d2438470ac51794
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HHIP CECR2 ROS1 MAPK10

2.38e-04198684f948391296c261c473d339069a6d0f20ccd6f38f
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HHIP CECR2 ROS1 MAPK10

2.38e-041986842e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

HHIP LMAN1 ERRFI1 ROS1

2.38e-04198684aa80315395cb5dffc25927c8a77cd2037aea8772
ToppCellBAL-Severe-Epithelial-Epithelial-AT1/AT2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HHIP BAIAP2L1 ERRFI1 ROS1

2.38e-04198684aed0476248e9637897eefb1623ec4035f2dacd82
ToppCellBAL-Severe-Epithelial-Epithelial-AT1/AT2|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

HHIP BAIAP2L1 ERRFI1 ROS1

2.38e-04198684e115eea04012e9e492e923ed080e1723c38d14fd
ToppCellBAL-Severe-Epithelial-Epithelial-AT1/AT2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HHIP BAIAP2L1 ERRFI1 ROS1

2.38e-0419868433d1e0b6f57663544bee0ffdde83a65da764d44c
ToppCellSevere_COVID-19-Epithelial-AT1/AT2|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

HHIP BAIAP2L1 ERRFI1 ROS1

2.38e-0419868443e33d28d9de5033bd00d39be953542a225236ed
ToppCell3'-GW_trimst-2-SmallIntestine|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TBX3 XDH CREB3L3 MAPK10

2.38e-04198684cc162ba4b3b8dec667a8cffd3411965f3f856f8c
Diseasetestosterone measurement

BMP5 CYP3A7 NF1 BAIAP2L1 CECR2 SEC23IP XDH PLAGL1 ZNF318 LARP4 MAPK10

1.30e-0412756711EFO_0004908
Diseasenucleus accumbens volume change measurement

MUC16 MAPK10

2.76e-0411672EFO_0021493
Diseasealkaline phosphatase measurement

NF1 POM121 BAIAP2L1 GLIS2 ZNF318 TNFRSF11A STKLD1 CNOT1 DNMT1

4.65e-041015679EFO_0004533
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

GRIA1 MED13

6.76e-0417672DOID:0060307 (is_implicated_in)
Diseaseetiocholanolone glucuronide measurement

CYP3A7 XDH

8.47e-0419672EFO_0800362
Diseasepancreatic cancer (is_marker_for)

ADAM15 MUC16 MUC4

1.59e-03101673DOID:1793 (is_marker_for)
DiseaseDevelopmental Academic Disorder

NF1 GRIA1

1.98e-0329672C1330966
DiseaseLearning Disorders

NF1 GRIA1

1.98e-0329672C0023186
DiseaseLearning Disturbance

NF1 GRIA1

1.98e-0329672C0751263
DiseaseAdult Learning Disorders

NF1 GRIA1

1.98e-0329672C0751262
DiseaseLearning Disabilities

NF1 GRIA1

1.98e-0329672C0751265

Protein segments in the cluster

PeptideGeneStartEntry
PLGPATQVPALFSAA

LINC00311

26

Q8N616
PFSFSQGPLKDAPNL

CTBP1

296

Q13363
FALIILPSISPFGPN

CREB3L3

331

Q68CJ9
LPPEAFTFNIKLSSP

DNMT1

941

P26358
RGTKQASALSFPAPP

ADAM15

756

Q13444
FSVKQNPLPSSFPGK

CREBRF

161

Q8IUR6
LKSVAFPPFPSGRNC

MACROH2A2

306

Q9P0M6
PELPKTSSFAASGPL

AP4B1

586

Q9Y6B7
GPLFTFKLLTEPESP

ADRA1B

471

P35368
VPAPSSLFGAPAQAL

CECR2

876

Q9BXF3
QPSPQASFLPGFGVK

RFWD3

466

Q6PCD5
PTTAGPLLVPFTLNF

MUC16

12691

Q8WXI7
DFTSPLFKPATGFPL

MUC4

4336

Q99102
GLTFPKLFPDSLFPA

MAPK10

306

P53779
GAAPFKAPPSVVFLA

CFAP65

1176

Q6ZU64
NGFTSPAFKPAASPL

LARP4B

386

Q92615
LSSFPPLPGAAGNLK

LARP4B

531

Q92615
FAKPSLSAQPGPAVS

GP6

111

Q9HCN6
SFLTFQLTEPGKEPP

LMAN1

261

P49257
SPGSPPSGFLLNSKF

GLIS2

51

Q9BZE0
LKPLKFSSNQPPAAG

INF2

1111

Q27J81
SAPSPAPKQSFLFGT

POM121C

671

A8CG34
FQFGKPPALPTTTTV

POM121B

466

A6NF01
TFNIPFGSSAKSPLP

POM121B

531

A6NF01
LSIFDPPPFKVTLTG

ICOS

111

Q9Y6W8
ASAPFNFTLPPNFGK

SLC10A1

6

Q14973
QATSAPSPAPKQSFL

POM121

691

Q96HA1
IFQFGKPPALPTTTT

POM121

881

Q96HA1
PTFNIPFGSSAKSPL

POM121

946

Q96HA1
LKEFLSNPPAGFPSS

ESPL1

26

Q14674
AKPPFLSGENPFATV

BAIAP2L1

481

Q9UHR4
NSSLPDKLPIFPDSA

ASCL3

6

Q9NQ33
RPFSPGKQASSAPLF

BMP5

66

P22003
KFDLLASNFPPLPGS

LARP4

476

Q71RC2
SALEKPNGATPVFNP

MBNL3

271

Q9NUK0
PTPLPFLGNALSFRK

CYP3A7

41

P24462
PQKSKPGVFSFLDPL

GRIA1

521

P42261
DLSQPPFSKSGRSFP

CCDC159

281

P0C7I6
LFFPLNSIPTPLSGQ

SLC7A3

461

Q8WY07
LSSPFDLNFPLPGEK

MCMBP

221

Q9BTE3
GFNKPAASATPFALP

NUP58

111

Q9BVL2
SFQLKAAALPPFPLG

PLAGL1

231

Q9UM63
FPALTLPPNGAAALS

TBX3

41

O15119
SSFPVLSPAFPSLIK

SPATA31A6

501

Q5VVP1
NSAFPLAALPQPGLS

PRR36

476

Q9H6K5
TLFIFPGLLPEAPSK

GPR108

136

Q9NPR9
DLSKKFPQLGATPFP

PRAM1

126

Q96QH2
APKALATGPNSPELF

PROSER3

51

Q2NL68
NAFSPSISKAQPGAP

SEC23IP

131

Q9Y6Y8
GAPGFPPQLLSSFIK

STARD9

4671

Q9P2P6
LNSGVSSNKLPSFPP

MED13

1546

Q9UHV7
FAENGPSQKSSLPPL

ERRFI1

81

Q9UJM3
SEPSLLEFKPFSNGP

HHIP

476

Q96QV1
ANKSLPPTFGPATLF

ANKHD1

2196

Q8IWZ3
GSAFSTPQSPAKAFP

CNOT1

741

A5YKK6
QPPSGLSSNQLSKFP

TRIM24

446

O15164
LDAKPPTPGASFSQA

SPEN

1731

Q96T58
SFPVLSPAFPSLIKN

SPATA31A1

506

Q5TZJ5
SFFPALALPPGALAK

TBX2

36

Q13207
LVSDSSAFSKPGLPP

STKLD1

651

Q8NE28
LLFNPSKPFSRGSQP

NF1

356

P21359
PTFASATLLFQKDPP

XDH

541

P47989
LPGNFSFTPKVIPDS

ROS1

936

P08922
APQGSNSKTPIFSPF

TBC1D30

861

Q9Y2I9
NVSSVVKPSFLPLPF

ZNF844

421

Q08AG5
RNPSFKPAPALSAAG

VRTN

446

Q9H8Y1
ASASSDAPPFQLGKP

SFXN5

16

Q8TD22
DLAFPGKSSLQSPNP

ZNF619

541

Q8N2I2
PSFSGFPLDSPKTLV

ZNF318

2066

Q5VUA4
GAVASLAAFPFPKPA

ZNF662

6

Q6ZS27
LFLTEPGSKSTPPFS

TNFRSF11A

361

Q9Y6Q6
SPKAIPNGFGTSPLT

NDEL1

231

Q9GZM8