Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix structural constituent

FBN1 VWF LAMA2 LAMA4 LAMB1 LTBP1 LTBP2 FBN3

1.92e-07188668GO:0005201
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZSCAN29 HOXA13 ZNF132 ZNF22 SALL1 ZNF33A ZNF544 ZNF283 ZNF726P1 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709 NOTCH2

2.73e-0612716616GO:0000987
GeneOntologyMolecularFunctioncalcium ion binding

STAB2 FBN1 CELSR3 NRXN1 LRP1 LTBP1 LTBP2 PRKCSH DLL1 FBN3 NOTCH2 LRP8

5.44e-067496612GO:0005509
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZSCAN29 HOXA13 ZNF132 ZNF22 SALL1 ZNF33A ZNF544 ZNF283 ZNF726P1 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709

1.00e-0512446615GO:0000978
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZSCAN29 HOXA13 ZNF132 ZNF22 SALL1 ZNF33A ZNF544 ZNF283 ZNF726P1 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709 NOTCH2

1.05e-0514126616GO:0000981
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

STAB2 LRP1 LRP8

1.87e-0516663GO:0005041
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

STAB2 LRP1 LRP8

4.40e-0521663GO:0030228
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZSCAN29 HOXA13 ZNF132 ZNF22 SALL1 ZNF33A ZNF544 ZNF283 ZNF726P1 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709

6.47e-0514596615GO:0000977
GeneOntologyMolecularFunctionscavenger receptor activity

STAB2 LRP1 MEGF10

9.53e-0527663GO:0005044
GeneOntologyMolecularFunctionmicrofibril binding

LTBP1 LTBP2

1.60e-046662GO:0050436
GeneOntologyMolecularFunctioncargo receptor activity

STAB2 LRP1 MEGF10 LRP8

1.80e-0485664GO:0038024
GeneOntologyMolecularFunctionapolipoprotein binding

LRP1 LRP8

1.97e-0320662GO:0034185
GeneOntologyMolecularFunctionstructural molecule activity

FBN1 VWF LAMA2 LAMA4 LAMB1 CLDN15 LTBP1 LTBP2 FBN3

2.54e-03891669GO:0005198
GeneOntologyMolecularFunctionintegrin binding

FBN1 VWF LAMB1 ADAM10

2.69e-03175664GO:0005178
GeneOntologyMolecularFunctionNotch binding

DLL1 MEGF10

3.58e-0327662GO:0005112
GeneOntologyBiologicalProcessregulation of muscle cell differentiation

LAMA2 LAMB1 DLL1 ZNF418 MEGF10 NOTCH2

3.85e-05199656GO:0051147
GeneOntologyBiologicalProcesscardiac chamber development

HOXA13 SALL1 WNT2 LRP1 LTBP1 NOTCH2

5.47e-05212656GO:0003205
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 LTBP1

5.84e-054652GO:0035583
GeneOntologyBiologicalProcesscardiac septum development

HOXA13 SALL1 LRP1 LTBP1 NOTCH2

6.49e-05134655GO:0003279
GeneOntologyBiologicalProcessendothelial cell fate specification

HOXA13 DLL1

9.72e-055652GO:0060847
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

CELSR3 NRXN1 UBE3A LRP1 LAMA2 LAMB1 ADAM10 TCTN1 NOTCH2 LRP8

1.09e-047486510GO:0048667
GeneOntologyBiologicalProcessheart development

HOXA13 FBN1 SALL1 WNT2 WIF1 LRP1 LTBP1 DLL1 ZNF418 NOTCH2

1.20e-047576510GO:0007507
GeneOntologyBiologicalProcesscirculatory system development

HOXA13 STAB2 FBN1 SALL1 NRXN1 WNT2 WIF1 LRP1 LAMA4 LTBP1 DLL1 ZNF418 ADAM10 NOTCH2

1.30e-0414426514GO:0072359
GeneOntologyBiologicalProcessneuron projection morphogenesis

CELSR3 NRXN1 UBE3A LRP1 LAMA2 LAMB1 ADAM10 TCTN1 NOTCH2 LRP8

1.93e-048026510GO:0048812
GeneOntologyBiologicalProcessvasculature development

HOXA13 STAB2 NRXN1 WNT2 WIF1 LRP1 LAMA4 LTBP1 DLL1 ADAM10 NOTCH2

2.03e-049696511GO:0001944
GeneOntologyBiologicalProcessWnt signaling pathway

SALL1 CELSR3 WNT2 TLE2 TLE3 TLE4 WIF1 LRP1

2.10e-04516658GO:0016055
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

CELSR3 NRXN1 UBE3A LRP1 LAMA2 LAMB1 ADAM10 TCTN1 NOTCH2 LRP8

2.28e-048196510GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

CELSR3 NRXN1 UBE3A LRP1 LAMA2 LAMB1 ADAM10 TCTN1 NOTCH2 LRP8

2.44e-048266510GO:0048858
GeneOntologyBiologicalProcessregulation of embryonic development

WNT2 LAMA2 LAMA4 DLL1

2.70e-0499654GO:0045995
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

FBN1 LTBP1

2.70e-048652GO:0071694
GeneOntologyBiologicalProcessaxon guidance

CELSR3 NRXN1 LRP1 LAMA2 LAMB1 NOTCH2

2.75e-04285656GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

CELSR3 NRXN1 LRP1 LAMA2 LAMB1 NOTCH2

2.81e-04286656GO:0097485
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

HOXA13 FBN1 NRXN1 UBE3A LRP1 LTBP1 LTBP2 DLL1 NOTCH2 LRP8

3.07e-048506510GO:0071363
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

HOXA13 FBN1 NRXN1 LRP1 LTBP1 DLL1 NOTCH2

3.10e-04412657GO:0090287
GeneOntologyBiologicalProcesscell morphogenesis

HOXA13 CELSR3 NRXN1 UBE3A ADAM7 LRP1 LAMA2 LAMB1 ADAM10 TCTN1 NOTCH2 LRP8

3.11e-0411946512GO:0000902
GeneOntologyBiologicalProcessendothelial cell fate commitment

HOXA13 DLL1

3.47e-049652GO:0060839
GeneOntologyBiologicalProcessnegative regulation of Wnt signaling pathway

TLE2 TLE3 TLE4 WIF1 LRP1

3.74e-04195655GO:0030178
GeneOntologyBiologicalProcessresponse to growth factor

HOXA13 FBN1 NRXN1 UBE3A LRP1 LTBP1 LTBP2 DLL1 NOTCH2 LRP8

4.15e-048836510GO:0070848
GeneOntologyBiologicalProcessgliogenesis

LRP1 LAMA2 LAMB1 DLL1 LGI4 NOTCH2 LRP8

4.29e-04435657GO:0042063
GeneOntologyBiologicalProcessmarginal zone B cell differentiation

DLL1 NOTCH2

4.33e-0410652GO:0002315
GeneOntologyBiologicalProcessproximal tubule development

DLL1 NOTCH2

4.33e-0410652GO:0072014
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

HOXA13 FBN1 WIF1 LRP1 LTBP1 LTBP2 NOTCH2

4.91e-04445657GO:0141091
GeneOntologyBiologicalProcesssequestering of extracellular ligand from receptor

FBN1 LTBP1

5.28e-0411652GO:0035581
GeneOntologyBiologicalProcessregulation of basement membrane organization

LAMA2 LAMB1

5.28e-0411652GO:0110011
GeneOntologyBiologicalProcessneuron development

CELSR3 NRXN1 UBE3A OTOGL LRP1 LAMA2 LAMB1 PRKCSH LGI4 ADAM10 TCTN1 NOTCH2 LRP8

5.55e-0414636513GO:0048666
GeneOntologyBiologicalProcessneuron projection development

CELSR3 NRXN1 UBE3A OTOGL LRP1 LAMA2 LAMB1 PRKCSH ADAM10 TCTN1 NOTCH2 LRP8

6.03e-0412856512GO:0031175
GeneOntologyBiologicalProcessblood vessel development

HOXA13 STAB2 NRXN1 WNT2 WIF1 LRP1 LAMA4 LTBP1 DLL1 NOTCH2

6.17e-049296510GO:0001568
GeneOntologyBiologicalProcessregulation of osteoclast development

FBN1 NOTCH2

7.46e-0413652GO:2001204
GeneOntologyBiologicalProcessextracellular regulation of signal transduction

FBN1 LTBP1

7.46e-0413652GO:1900115
GeneOntologyBiologicalProcessextracellular negative regulation of signal transduction

FBN1 LTBP1

7.46e-0413652GO:1900116
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

HOXA13 FBN1 WIF1 LRP1 LTBP1 LTBP2 NOTCH2

7.87e-04482657GO:0007178
GeneOntologyBiologicalProcesspositive regulation of cell differentiation

SALL1 RANBP3L WNT2 ADAM7 WIF1 LRP1 LAMA2 LRP3 LAMB1 NOTCH2 LRP8

8.07e-0411416511GO:0045597
GeneOntologyBiologicalProcesspositive regulation of integrin-mediated signaling pathway

LAMA2 LAMB1

8.68e-0414652GO:2001046
GeneOntologyBiologicalProcessleft/right axis specification

DLL1 NOTCH2

8.68e-0414652GO:0070986
GeneOntologyBiologicalProcessregulation of Wnt signaling pathway

SALL1 TLE2 TLE3 TLE4 WIF1 LRP1

1.05e-03368656GO:0030111
GeneOntologyBiologicalProcessregulation of dendritic spine morphogenesis

UBE3A ADAM10 LRP8

1.08e-0364653GO:0061001
GeneOntologyCellularComponentextracellular matrix

FBN1 VWF OTOGL WNT2 LAMA2 LAMA4 ADAMTS18 LAMB1 PLAT LTBP1 LTBP2 ADAM10 USH2A FBN3

1.34e-086566614GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

FBN1 VWF OTOGL WNT2 LAMA2 LAMA4 ADAMTS18 LAMB1 PLAT LTBP1 LTBP2 ADAM10 USH2A FBN3

1.39e-086586614GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

FBN1 VWF WNT2 LAMA2 LAMA4 LAMB1 PLAT LTBP1 LTBP2 ADAM10 USH2A

7.64e-075306611GO:0062023
GeneOntologyCellularComponentmicrofibril

FBN1 LTBP1 FBN3

8.41e-0613663GO:0001527
GeneOntologyCellularComponentbasement membrane

FBN1 LAMA2 LAMA4 LAMB1 USH2A

4.19e-05122665GO:0005604
GeneOntologyCellularComponentcell surface

STAB2 VWF NRXN1 LMO7 WIF1 LRP1 CORIN PLAT ADAM10 NOTCH2 LRP8

6.62e-0411116611GO:0009986
GeneOntologyCellularComponentbeta-catenin-TCF complex

TLE3 TLE4

7.49e-0413662GO:1990907
GeneOntologyCellularComponentprotein complex involved in cell adhesion

NRXN1 LAMA2 LAMB1

8.61e-0459663GO:0098636
GeneOntologyCellularComponentprotein complex involved in cell-matrix adhesion

LAMA2 LAMB1

1.29e-0317662GO:0098637
DomainEGF_1

STAB2 FBN1 CELSR3 NRXN1 WIF1 LRP1 LAMA2 LAMA4 LAMB1 PLAT LTBP1 LTBP2 DLL1 USH2A FBN3 MEGF10 NOTCH2 LRP8

3.06e-192556418PS00022
DomainEGF

STAB2 FBN1 CELSR3 NRXN1 WIF1 LRP1 LAMA2 LAMA4 LAMB1 PLAT LTBP1 LTBP2 DLL1 FBN3 MEGF10 NOTCH2 LRP8

2.26e-182356417SM00181
DomainEGF-like_dom

STAB2 FBN1 CELSR3 NRXN1 WIF1 LRP1 LAMA2 LAMA4 LAMB1 PLAT LTBP1 LTBP2 DLL1 FBN3 MEGF10 NOTCH2 LRP8

6.06e-182496417IPR000742
DomainEGF-like_CS

STAB2 FBN1 CELSR3 NRXN1 WIF1 LRP1 LAMA2 LAMA4 LAMB1 PLAT LTBP1 LTBP2 DLL1 FBN3 MEGF10 NOTCH2 LRP8

1.34e-172616417IPR013032
DomainEGF_2

STAB2 FBN1 CELSR3 NRXN1 WIF1 LRP1 LAMA2 LAMB1 PLAT LTBP1 LTBP2 DLL1 FBN3 MEGF10 NOTCH2 LRP8

4.56e-162656416PS01186
DomainEGF

STAB2 CELSR3 NRXN1 WIF1 LRP1 PLAT LTBP1 LTBP2 DLL1 FBN3 NOTCH2 LRP8

1.27e-141266412PF00008
DomainEGF_3

STAB2 FBN1 CELSR3 NRXN1 WIF1 LRP1 PLAT LTBP1 LTBP2 DLL1 FBN3 MEGF10 NOTCH2 LRP8

4.63e-142356414PS50026
DomainASX_HYDROXYL

FBN1 CELSR3 NRXN1 LRP1 LTBP1 LTBP2 DLL1 FBN3 NOTCH2 LRP8

1.46e-121006410PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

FBN1 CELSR3 NRXN1 LRP1 LTBP1 LTBP2 DLL1 FBN3 NOTCH2 LRP8

2.64e-121066410IPR000152
DomainEGF_CA

STAB2 FBN1 CELSR3 LRP1 LTBP1 LTBP2 DLL1 FBN3 NOTCH2 LRP8

1.09e-111226410SM00179
DomainEGF-like_Ca-bd_dom

STAB2 FBN1 CELSR3 LRP1 LTBP1 LTBP2 DLL1 FBN3 NOTCH2 LRP8

1.29e-111246410IPR001881
DomainEGF_Lam

STAB2 CELSR3 LAMA2 LAMA4 LAMB1 USH2A MEGF10

2.47e-1135647SM00180
DomainLaminin_EGF

STAB2 CELSR3 LAMA2 LAMA4 LAMB1 USH2A MEGF10

4.59e-1138647IPR002049
DomainGrowth_fac_rcpt_

STAB2 FBN1 LRP1 LAMB1 LTBP1 LTBP2 DLL1 FBN3 NOTCH2 LRP8

1.27e-101566410IPR009030
DomainEGF_LAM_2

STAB2 CELSR3 LAMA2 LAMA4 LAMB1 USH2A

7.09e-1030646PS50027
DomainEGF_LAM_1

STAB2 CELSR3 LAMA2 LAMA4 LAMB1 USH2A

7.09e-1030646PS01248
DomainEGF_Ca-bd_CS

FBN1 LRP1 LTBP1 LTBP2 DLL1 FBN3 NOTCH2 LRP8

1.38e-0997648IPR018097
DomainEGF_CA

FBN1 LRP1 LTBP1 LTBP2 DLL1 FBN3 NOTCH2 LRP8

1.62e-0999648PS01187
DomainLaminin_EGF

CELSR3 LAMA2 LAMA4 LAMB1 USH2A MEGF10

1.91e-0935646PF00053
DomainTB

FBN1 LTBP1 LTBP2 FBN3

4.35e-097644PF00683
Domain-

FBN1 LTBP1 LTBP2 FBN3

8.69e-0986443.90.290.10
DomainTB

FBN1 LTBP1 LTBP2 FBN3

1.56e-089644PS51364
DomainTB_dom

FBN1 LTBP1 LTBP2 FBN3

1.56e-089644IPR017878
DomainEGF_CA

FBN1 LRP1 LTBP1 LTBP2 FBN3 NOTCH2 LRP8

1.72e-0886647PF07645
DomainhEGF

WIF1 DLL1 FBN3 MEGF10 NOTCH2

3.73e-0828645PF12661
Domain-

ZSCAN29 ZNF132 ZNF22 SALL1 ZNF33A ZNF544 ZNF283 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709 ZNF654

5.48e-0867964143.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

ZSCAN29 ZNF132 ZNF22 SALL1 ZNF33A ZNF544 ZNF283 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709 ZNF654

7.18e-086946414IPR013087
DomainLAM_G_DOMAIN

CELSR3 NRXN1 LAMA2 LAMA4 USH2A

1.85e-0738645PS50025
DomainLaminin_G_2

CELSR3 NRXN1 LAMA2 LAMA4 USH2A

2.42e-0740645PF02210
DomainZINC_FINGER_C2H2_2

ZSCAN29 ZNF132 ZNF22 SALL1 ZNF33A ZNF544 ZNF283 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709 ZNF654

2.77e-077756414PS50157
DomainZINC_FINGER_C2H2_1

ZSCAN29 ZNF132 ZNF22 SALL1 ZNF33A ZNF544 ZNF283 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709 ZNF654

2.86e-077776414PS00028
DomainKRAB

ZNF132 ZNF33A ZNF544 ZNF283 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709

3.57e-073586410PS50805
DomainKRAB

ZNF132 ZNF33A ZNF544 ZNF283 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709

3.57e-073586410PF01352
DomainGroucho_enhance

TLE2 TLE3 TLE4

3.82e-075643IPR009146
DomainTLE_N

TLE2 TLE3 TLE4

3.82e-075643PF03920
DomainGroucho/TLE_N

TLE2 TLE3 TLE4

3.82e-075643IPR005617
DomainZnf_C2H2-like

ZSCAN29 ZNF132 ZNF22 SALL1 ZNF33A ZNF544 ZNF283 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709 ZNF654

3.83e-077966414IPR015880
DomainLamG

CELSR3 NRXN1 LAMA2 LAMA4 USH2A

3.95e-0744645SM00282
DomainZnf_C2H2

ZSCAN29 ZNF132 ZNF22 SALL1 ZNF33A ZNF544 ZNF283 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709 ZNF654

4.39e-078056414IPR007087
DomainZnF_C2H2

ZSCAN29 ZNF132 ZNF22 SALL1 ZNF33A ZNF544 ZNF283 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709 ZNF654

4.59e-078086414SM00355
DomainKRAB

ZNF132 ZNF33A ZNF544 ZNF283 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709

4.71e-073696410SM00349
DomainKRAB

ZNF132 ZNF33A ZNF544 ZNF283 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709

4.82e-073706410IPR001909
Domain-

LRP1 LRP3 CORIN PRKCSH LRP8

4.96e-07466454.10.400.10
Domainzf-C2H2

ZSCAN29 ZNF132 ZNF22 SALL1 ZNF33A ZNF544 ZNF283 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709

5.18e-076936413PF00096
DomainLDrepeatLR_classA_rpt

LRP1 LRP3 CORIN PRKCSH LRP8

6.84e-0749645IPR002172
DomainLDLa

LRP1 LRP3 CORIN PRKCSH LRP8

6.84e-0749645SM00192
DomainLaminin_G

CELSR3 NRXN1 LAMA2 LAMA4 USH2A

1.61e-0658645IPR001791
DomaincEGF

FBN1 LRP1 LTBP1 FBN3

1.77e-0626644IPR026823
DomaincEGF

FBN1 LRP1 LTBP1 FBN3

1.77e-0626644PF12662
DomainLDLR_class-A_CS

LRP1 LRP3 CORIN LRP8

1.04e-0540644IPR023415
DomainLdl_recept_a

LRP1 LRP3 CORIN LRP8

1.68e-0545644PF00057
Domain-

CELSR3 NRXN1 LAMA2 LAMA4 USH2A

1.84e-05956452.60.120.200
DomainLaminin_N

LAMA2 LAMB1 USH2A

2.08e-0516643IPR008211
DomainLAMININ_NTER

LAMA2 LAMB1 USH2A

2.08e-0516643PS51117
DomainLaminin_N

LAMA2 LAMB1 USH2A

2.08e-0516643PF00055
DomainLamNT

LAMA2 LAMB1 USH2A

2.08e-0516643SM00136
DomainLDLRA_1

LRP1 LRP3 CORIN LRP8

2.18e-0548644PS01209
DomainLDLRA_2

LRP1 LRP3 CORIN LRP8

2.37e-0549644PS50068
DomainFBN

FBN1 FBN3

3.46e-053642IPR011398
DomainEGF_extracell

STAB2 WIF1 LTBP2 MEGF10

5.29e-0560644IPR013111
DomainEGF_2

STAB2 WIF1 LTBP2 MEGF10

5.29e-0560644PF07974
DomainPrefoldin

TLE2 TLE3 TLE4 LAMB1

1.08e-0472644IPR009053
DomainLaminin_aI

LAMA2 LAMA4

1.15e-045642IPR009254
DomainLaminin_I

LAMA2 LAMA4

1.15e-045642PF06008
DomainLaminin_II

LAMA2 LAMA4

1.15e-045642PF06009
DomainLaminin_domII

LAMA2 LAMA4

1.15e-045642IPR010307
DomainPeptidase_M12B_N

ADAM7 ADAMTS18 ADAM10

3.21e-0439643IPR002870
DomainPep_M12B_propep

ADAM7 ADAMTS18 ADAM10

3.21e-0439643PF01562
DomainDISINTEGRIN_1

ADAM7 ADAMTS18 ADAM10

3.46e-0440643PS00427
DomainReprolysin

ADAM7 ADAMTS18 ADAM10

3.46e-0440643PF01421
DomainADAM_MEPRO

ADAM7 ADAMTS18 ADAM10

3.46e-0440643PS50215
DomainDISINTEGRIN_2

ADAM7 ADAMTS18 ADAM10

3.46e-0440643PS50214
DomainPeptidase_M12B

ADAM7 ADAMTS18 ADAM10

3.46e-0440643IPR001590
DomainDisintegrin_dom

ADAM7 ADAMTS18 ADAM10

3.73e-0441643IPR001762
DomainConA-like_dom

CELSR3 NRXN1 LAMA2 LAMA4 USH2A

9.20e-04219645IPR013320
DomainLdl_recept_b

LRP1 LRP8

1.02e-0314642PF00058
DomainLDLRB

LRP1 LRP8

1.02e-0314642PS51120
DomainLY

LRP1 LRP8

1.18e-0315642SM00135
DomainLDLR_classB_rpt

LRP1 LRP8

1.18e-0315642IPR000033
Domain-

ADAM7 ADAM10

2.11e-03206424.10.70.10
DomainDisintegrin

ADAM7 ADAM10

2.33e-0321642PF00200
DomainDISIN

ADAM7 ADAM10

2.33e-0321642SM00050
DomainMetalloPept_cat_dom

ADAM7 ADAMTS18 ADAM10

2.71e-0381643IPR024079
Domain-

ADAM7 ADAMTS18 ADAM10

2.71e-03816433.40.390.10
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

FBN1 VWF NRXN1 LAMA2 LAMA4 ADAMTS18 LAMB1 LTBP1 LTBP2 ADAM10 FBN3

6.03e-093005011M610
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

FBN1 LTBP1 LTBP2 FBN3

1.68e-0625504M39713
PathwayREACTOME_REPRESSION_OF_WNT_TARGET_GENES

TLE2 TLE3 TLE4

4.95e-0610503MM15156
PathwayREACTOME_SIGNALING_BY_NOTCH1

TLE2 TLE3 TLE4 DLL1 ADAM10

6.13e-0674505M616
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN1 LTBP1 LTBP2 FBN3

8.48e-0637504M27134
PathwayREACTOME_REPRESSION_OF_WNT_TARGET_GENES

TLE2 TLE3 TLE4

1.49e-0514503M27402
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN1 LTBP1 LTBP2 FBN3

1.71e-0544504M26969
PathwayREACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS

NRXN1 LAMA2 LAMA4 LAMB1

5.52e-0559504M27218
PathwayREACTOME_NOTCH2_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

DLL1 ADAM10 NOTCH2

6.17e-0522503M27210
PathwayREACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS

FBN1 LAMB1 LTBP1 PRKCSH ADAM10

7.50e-05124505M27285
PathwayPID_INTEGRIN1_PATHWAY

FBN1 LAMA2 LAMA4 LAMB1

8.58e-0566504M18
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

TLE2 TLE3 TLE4

1.03e-0426503MM14793
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

DLL1 ADAM10 NOTCH2

1.16e-0427503M39545
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

FBN1 ADAMTS18 LAMB1 ADAM10 FBN3

1.33e-04140505M587
PathwayREACTOME_MET_ACTIVATES_PTK2_SIGNALING

LAMA2 LAMA4 LAMB1

1.59e-0430503M27772
PathwayREACTOME_LAMININ_INTERACTIONS

LAMA2 LAMA4 LAMB1

1.59e-0430503M27216
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN1 LTBP1 LTBP2

1.94e-0432503MM14854
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

TLE2 TLE3 TLE4

1.94e-0432503MM14975
PathwayREACTOME_SIGNALING_BY_NOTCH2

DLL1 ADAM10 NOTCH2

2.13e-0433503M604
PathwayKEGG_ECM_RECEPTOR_INTERACTION

VWF LAMA2 LAMA4 LAMB1

2.19e-0484504M7098
PathwayREACTOME_SIGNALING_BY_NOTCH

TLE2 TLE3 TLE4 DLL1 ADAM10 NOTCH2

2.22e-04246506M10189
PathwayREACTOME_SIGNALING_BY_NOTCH1_T_7_9_NOTCH1_M1580_K2555_TRANSLOCATION_MUTANT

DLL1 ADAM10

2.56e-047502M27199
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

FBN1 VWF LAMA4 LTBP1 LTBP2 ADAM10

2.87e-04258506MM14572
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

FBN1 LTBP1 LTBP2

3.25e-0438503MM14874
PathwayKEGG_MEDICUS_REFERENCE_PLASMIN_MEDIATED_ACTIVATION_OF_LATENT_TGF_BETA

FBN1 LTBP1

3.41e-048502M47850
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN1 LTBP1 LTBP2

3.51e-0439503MM14601
PathwayREACTOME_MET_PROMOTES_CELL_MOTILITY

LAMA2 LAMA4 LAMB1

4.07e-0441503M27778
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

TLE2 TLE3 TLE4

4.37e-0442503M27272
PathwayPID_INTEGRIN3_PATHWAY

FBN1 LAMA4 LAMB1

4.69e-0443503M53
PathwayPID_A6B1_A6B4_INTEGRIN_PATHWAY

LAMA2 LAMA4 LAMB1

5.72e-0446503M239
PathwayREACTOME_KIDNEY_DEVELOPMENT

SALL1 WFDC2 DLL1

5.72e-0446503M48243
PathwayPID_PS1_PATHWAY

WIF1 DLL1 ADAM10

5.72e-0446503M70
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

FBN1 LTBP1 LTBP2

6.10e-0447503M646
PathwayREACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

TLE2 TLE3 TLE4

6.49e-0448503M611
PathwayPID_INTEGRIN4_PATHWAY

LAMA2 LAMB1

6.64e-0411502M158
PathwayBIOCARTA_HES_PATHWAY

DLL1 NOTCH2

7.95e-0412502MM1562
PathwayBIOCARTA_HES_PATHWAY

DLL1 NOTCH2

7.95e-0412502M22042
PathwayREACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS

FBN1 LTBP1 PRKCSH ADAM10

8.50e-04120504MM14982
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

DLL1 NOTCH2

9.38e-0413502M47423
PathwayPID_NOTCH_PATHWAY

DLL1 ADAM10 NOTCH2

1.19e-0359503M17
PathwayREACTOME_SIGNALING_BY_NOTCH1_HD_DOMAIN_MUTANTS_IN_CANCER

DLL1 ADAM10

1.26e-0315502M27202
PathwayWP_NOTCH1_REGULATION_OF_ENDOTHELIAL_CELL_CALCIFICATION

PLAT DLL1

1.62e-0317502M39389
PathwayREACTOME_SIGNALING_BY_NOTCH3

DLL1 ADAM10

2.03e-0319502MM15594
PathwayREACTOME_ECM_PROTEOGLYCANS

LAMA2 LAMA4 LAMB1

2.46e-0376503M27219
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

WNT2 CLDN15 DLL1 NOTCH2

2.51e-03161504M39770
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

FBN1 LTBP1 LTBP2

2.55e-0377503MM14670
PathwayWP_BLOOD_CLOTTING_CASCADE

VWF PLAT

2.72e-0322502M39480
PathwayREACTOME_SIGNALING_BY_MET

LAMA2 LAMA4 LAMB1

2.75e-0379503M27643
PathwayREACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX

TLE2 TLE3 TLE4

2.75e-0379503MM14754
PathwayWP_BLOOD_CLOTTING_CASCADE

VWF PLAT

2.97e-0323502MM15936
PathwayWP_DELTANOTCH_SIGNALING_PATHWAY

DLL1 ADAM10 NOTCH2

3.05e-0382503MM15922
PathwayKEGG_SMALL_CELL_LUNG_CANCER

LAMA2 LAMA4 LAMB1

3.27e-0384503M3228
PathwayREACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX

TLE2 TLE3 TLE4

3.38e-0385503M27079
PathwayREACTOME_NOTCH3_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

DLL1 ADAM10

3.51e-0325502M27879
PathwayWNT_SIGNALING

WNT2 TLE2 WIF1

3.85e-0389503M5493
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

TLE2 TLE3 TLE4

4.10e-0391503M27101
PathwayWP_FOCAL_ADHESION

VWF LAMA2 LAMA4 LAMB1

4.29e-03187504MM15913
PathwayPID_WNT_SIGNALING_PATHWAY

WNT2 WIF1

4.39e-0328502M77
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_INHIBITOR

WNT2 WIF1

4.39e-0328502M47835
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

FBN1 LTBP1 LTBP2

4.49e-0394503M1041
PathwayREACTOME_EGR2_AND_SOX10_MEDIATED_INITIATION_OF_SCHWANN_CELL_MYELINATION

LAMA2 LAMB1

4.71e-0329502M29808
PathwayWP_SMALL_CELL_LUNG_CANCER

LAMA2 LAMA4 LAMB1

4.76e-0396503M39834
PathwayWP_FOCAL_ADHESION

VWF LAMA2 LAMA4 LAMB1

5.35e-03199504M39402
PathwayKEGG_FOCAL_ADHESION

VWF LAMA2 LAMA4 LAMB1

5.35e-03199504M7253
PathwayBIOCARTA_AGR_PATHWAY

LAMA2 LAMA4

5.37e-0331502MM1343
PathwayREACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS

DLL1 ADAM10

5.37e-0331502M592
PathwayWP_ALPHA_6_BETA_4_SIGNALING

LAMA2 LAMB1

6.07e-0333502M39503
PathwayBIOCARTA_AGR_PATHWAY

LAMA2 LAMA4

6.07e-0333502M6220
PathwayREACTOME_SIGNALING_BY_WNT

WNT2 TLE2 TLE3 TLE4 WIF1

6.10e-03330505M7847
PathwayWP_WNT_SIGNALING_PATHWAY

SALL1 WNT2 LRP1

6.94e-03110503MM15977
Pubmed

Coexpression of Cux-1 and Notch signaling pathway components during kidney development.

TLE2 TLE3 TLE4 DLL1 NOTCH2

1.04e-111167515499562
Pubmed

Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.

TLE2 TLE3 TLE4 NOTCH2

6.28e-1156741303260
Pubmed

Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway.

TLE2 TLE3 TLE4 DLL1 NOTCH2

6.74e-11156759291577
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

FBN1 VWF LAMA2 LAMA4 LAMB1 LTBP1 LTBP2 ADAM10

1.22e-0916767822159717
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

FBN1 VWF LAMA2 LAMA4 LAMB1 LTBP1 LTBP2 ADAM10

1.77e-0917567828071719
Pubmed

LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein.

FBN1 LTBP1 LTBP2

6.83e-09367317293099
Pubmed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

FBN1 VWF LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.40e-0814667727068509
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

FBN1 VWF LAMA2 LAMA4 LAMB1 LTBP1 LTBP2 ADAM10

2.71e-0824867824006456
Pubmed

TLE expression correlates with mouse embryonic segmentation, neurogenesis, and epithelial determination.

TLE2 TLE3 TLE4

2.73e-0846738645603
Pubmed

Laminin alpha 1, alpha 2, alpha 4 and beta 1 chain mRNA expression in mouse embryonic, neonatal, and adult hearts.

LAMA2 LAMA4 LAMB1

2.73e-0846739201115
Pubmed

Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.

TLE2 TLE3 TLE4

6.81e-0856738365415
Pubmed

Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex.

TLE2 TLE3 TLE4

1.36e-0766738573724
Pubmed

Adamts18 modulates the development of the aortic arch and common carotid artery.

FBN1 ADAMTS18 LAMB1 ADAM10

1.82e-072667434189436
Pubmed

A Gro/TLE-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression.

TLE2 TLE3 TLE4

2.38e-07767324024827
Pubmed

Laminin isoforms in fetal and adult human adrenal cortex.

LAMA2 LAMA4 LAMB1

2.38e-07767314557481
Pubmed

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

FBN1 VWF LAMA2 LAMA4 LAMB1 LTBP1

2.51e-0713567628675934
Pubmed

The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1.

TLE2 TLE3 TLE4

3.80e-07867316002402
Pubmed

Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling.

TLE2 TLE3 TLE4

3.80e-07867320735826
Pubmed

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

FBN1 VWF LAMA2 LAMA4 LAMB1 LTBP1

5.25e-0715367625037231
Pubmed

Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.

FBN1 WNT2 ADAMTS18 LAMB1

7.92e-073767434323105
Pubmed

Distribution of the ten known laminin chains in the pathways and targets of developing sensory axons.

LAMA2 LAMA4 LAMB1

8.12e-07106739034910
Pubmed

Spatial distribution of the full-length members of the Grg family during embryonic neurogenesis reveals a "Grg-mediated repression map" in the mouse telencephalon.

TLE2 TLE3 TLE4

8.12e-071067330571765
Pubmed

Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro.

LAMA2 LAMA4 LAMB1

8.12e-071067318590826
Pubmed

Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryo.

LAMA2 LAMA4 LAMB1

8.12e-071067311784026
Pubmed

Regional differences in the expression of laminin isoforms during mouse neural tube development.

LAMA2 LAMA4 LAMB1

1.12e-061167321524702
Pubmed

Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities.

LAMA2 LAMA4 LAMB1

1.12e-061167323472759
Pubmed

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.

FBN1 LAMA2 LAMA4 LAMB1 LTBP2

1.28e-069767527559042
Pubmed

Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice.

LAMA2 LAMA4 LAMB1

1.48e-06126739396756
Pubmed

All Tcf HMG box transcription factors interact with Groucho-related co-repressors.

TLE2 TLE3 TLE4

1.48e-061267311266540
Pubmed

The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut.

LAMA2 LAMA4 LAMB1

1.93e-061367336350252
Pubmed

Neurog2 simultaneously activates and represses alternative gene expression programs in the developing neocortex.

TLE2 TLE3 TLE4

1.93e-061367322735158
Pubmed

Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.

TLE2 TLE3 TLE4

2.45e-061467317202186
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

UBE2J1 FBN1 CELSR3 LRP1 LAMA4 LAMB1 LTBP1 LTBP2 PRKCSH ADAM10 NOTCH2 LRP8

2.83e-061201671235696571
Pubmed

Basement membrane composition in the early mouse embryo day 7.

LAMA2 LAMA4 LAMB1

3.06e-061567315895400
Pubmed

Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane.

LAMA2 LAMA4 LAMB1

3.06e-061567310625553
Pubmed

Laminin alpha5 chain is required for intestinal smooth muscle development.

LAMA2 LAMA4 LAMB1

3.06e-061567312921739
Pubmed

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.

FBN1 VWF LRP1 LAMB1 LTBP1

3.37e-0611867521078624
Pubmed

Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

LRP1 PLAT

3.66e-0626721502153
Pubmed

Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism.

DLL1 NOTCH2

3.66e-06267214660750
Pubmed

Latent transforming growth factor-β binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization.

LTBP1 LTBP2

3.66e-06267225858550
Pubmed

The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors.

LRP1 PLAT

3.66e-06267218321860
Pubmed

Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase.

LRP1 LRP8

3.66e-06267212871934
Pubmed

The N-Terminal Region of Fibrillin-1 Mediates a Bipartite Interaction with LTBP1.

FBN1 LTBP1

3.66e-06267228669633
Pubmed

Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression.

TLE3 TLE4

3.66e-06267225446531
Pubmed

TLE3 and TLE4-coordinated colonic macrophage-CD4+ T cell crosstalk maintains intestinal immune homeostasis.

TLE3 TLE4

3.66e-06267236801171
Pubmed

Recombinant Tissue Plasminogen Activator (r-tPA) Induces In-Vitro Human Neutrophil Migration via Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1).

LRP1 PLAT

3.66e-06267232977685
Pubmed

Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation.

LRP1 PLAT

3.66e-06267210632583
Pubmed

The transcriptional co-repressor TLE3 regulates development of trophoblast giant cells lining maternal blood spaces in the mouse placenta.

TLE3 NOTCH2

3.66e-06267223954203
Pubmed

Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.

FBN1 FBN3

3.66e-06267215221638
Pubmed

Inhibition of ADAM10 promotes the clearance of Aβ across the BBB by reducing LRP1 ectodomain shedding.

LRP1 ADAM10

3.66e-06267227503326
Pubmed

Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1.

LRP1 PLAT

3.66e-06267226237273
Pubmed

Coordinate control of axon defasciculation and myelination by laminin-2 and -8.

LAMA2 LAMA4

3.66e-06267215699217
Pubmed

Exome sequencing identified new mutations in a Marfan syndrome family.

FBN1 LRP1

3.66e-06267224484584
Pubmed

Laminins alpha2 and alpha4 in pancreatic acinar basement membranes are required for basal receptor localization.

LAMA2 LAMA4

3.66e-06267214729866
Pubmed

Ca2+ -regulated secretion of tissue-type plasminogen activator and von Willebrand factor in human endothelial cells.

VWF PLAT

3.66e-06267212445472
Pubmed

Impairment of thymocyte development by dominant-negative Kuzbanian (ADAM-10) is rescued by the Notch ligand, delta-1.

DLL1 ADAM10

3.66e-06267215905513
Pubmed

Confocal microscopy demonstrates association of LTBP-2 in fibrillin-1 microfibrils and colocalisation with perlecan in the disc cell pericellular matrix.

FBN1 LTBP2

3.66e-06267224867584
Pubmed

Dual genetic diagnoses: Atypical hand-foot-genital syndrome and developmental delay due to de novo mutations in HOXA13 and NRXN1.

HOXA13 NRXN1

3.66e-06267226590955
Pubmed

Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling.

LAMA2 LAMA4 LAMB1

3.76e-061667317601529
Pubmed

Beta1-integrins are critical for cerebellar granule cell precursor proliferation.

LAMA2 LAMA4 LAMB1

4.56e-061767315056720
Pubmed

Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.

LAMA2 LAMA4 LAMB1

5.46e-061867311311202
Pubmed

Groucho co-repressor proteins regulate β cell development and proliferation by repressing Foxa1 in the developing mouse pancreas.

TLE2 TLE3 TLE4

5.46e-061867333658226
Pubmed

ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.

FBN1 ADAMTS18 LAMB1

5.46e-061867339040056
Pubmed

Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis.

TLE2 TLE3 TLE4

5.46e-061867311731482
Pubmed

Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: implications for regulation of BMP signalling.

LAMA2 LAMA4 LAMB1

7.61e-062067322911573
Pubmed

Transcriptional regulation of cortical neuron migration by POU domain factors.

TLE3 TLE4 LRP8

7.61e-062067311859196
Pubmed

Schwann cell myelination requires integration of laminin activities.

LAMA2 LAMA4 LAMB1

8.87e-062167322767514
Pubmed

Impaired fetal muscle development and JAK-STAT activation mark disease onset and progression in a mouse model for merosin-deficient congenital muscular dystrophy.

LAMA2 LAMA4 DLL1

1.03e-052267328334989
Pubmed

Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning.

SALL1 LAMB1 DLL1

1.03e-052267329449451
Pubmed

Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor.

LRP1 ADAM10

1.10e-05367230279425
Pubmed

Tissue-type plasminogen activator (tPA) promotes M1 macrophage survival through p90 ribosomal S6 kinase (RSK) and p38 mitogen-activated protein kinase (MAPK) pathway.

LRP1 PLAT

1.10e-05367225670857
Pubmed

Laminin α2, α4, and α5 Chains Positively Regulate Migration and Survival of Oligodendrocyte Precursor Cells.

LAMA2 LAMA4

1.10e-05367231882770
Pubmed

Characterization and expression of the laminin gamma3 chain: a novel, non-basement membrane-associated, laminin chain.

LAMA2 LAMB1

1.10e-05367210225960
Pubmed

Cloning of the mouse laminin alpha 4 cDNA. Expression in a subset of endothelium.

LAMA4 LAMB1

1.10e-0536729219532
Pubmed

Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo.

LRP1 LRP8

1.10e-05367224251389
Pubmed

Notch signaling confers antigen-presenting cell functions on mast cells.

DLL1 NOTCH2

1.10e-05367219130928
Pubmed

Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein.

LRP1 PLAT

1.10e-05367219608750
Pubmed

Tissue-type plasminogen activator regulates macrophage activation and innate immunity.

LRP1 PLAT

1.10e-05367228684538
Pubmed

Shear stress-independent binding of von Willebrand factor-type 2B mutants p.R1306Q & p.V1316M to LRP1 explains their increased clearance.

VWF LRP1

1.10e-05367225728415
Pubmed

The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity.

STAB2 VWF

1.10e-05367230124466
Pubmed

Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit.

LRP1 PLAT

1.10e-05367217170123
Pubmed

Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression.

LRP1 PLAT

1.10e-05367216303771
Pubmed

LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.

LRP1 PLAT

1.10e-05367224129569
Pubmed

Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia.

TLE2 TLE3

1.10e-0536728808280
Pubmed

Microglial low-density lipoprotein receptor-related protein 1 mediates the effect of tissue-type plasminogen activator on matrix metalloproteinase-9 activity in the ischemic brain.

LRP1 PLAT

1.10e-05367219672275
Pubmed

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase.

DLL1 ADAM10

1.10e-05367212794186
Pubmed

Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain.

DLL1 NOTCH2

1.10e-05367211823422
Pubmed

Recombinant von Willebrand factor-insight into structure and function through infusion studies in animals with severe von Willebrand disease.

VWF LRP1

1.10e-05367211992244
Pubmed

Conclusion of diagnostic odysseys due to inversions disrupting GLI3 and FBN1.

HOXA13 FBN1

1.10e-05367236411030
Pubmed

Developmental expression and cellular origin of the laminin alpha2, alpha4, and alpha5 chains in the intestine.

LAMA2 LAMA4

1.10e-05367210364433
Pubmed

Increased levels of endothelial haemostatic markers in patients with coronary heart disease.

VWF PLAT

1.10e-05367211864703
Pubmed

Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'.

LRP1 LRP8

1.10e-05367212807892
Pubmed

Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells.

DLL1 NOTCH2

1.10e-05367215976178
Pubmed

Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity.

TLE3 TLE4

1.10e-05367230045946
Pubmed

Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action.

LTBP1 LTBP2

1.10e-05367210743502
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

FBN1 NRXN1 LRP1 LAMA2

1.11e-057167433541421
Pubmed

Expression of Groucho/TLE proteins during pancreas development.

TLE2 TLE3 TLE4

1.34e-052467318778483
Pubmed

Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.

LAMA2 LAMA4 LAMB1

1.72e-052667324742657
Pubmed

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

FBN1 LTBP1

2.19e-05467212429738
Pubmed

Heterogeneity of Satellite Cells Implicates DELTA1/NOTCH2 Signaling in Self-Renewal.

DLL1 NOTCH2

2.19e-05467232023464
InteractionHLX interactions

LMO7 TLE2 TLE3 TLE4

6.01e-0637654int:HLX
InteractionZNF709 interactions

LTBP2 ZNF709 NOTCH2

8.95e-0613653int:ZNF709
InteractionZNF324 interactions

LRP3 LTBP2 ZNF543 NOTCH2

1.45e-0546654int:ZNF324
InteractionZNF708 interactions

LTBP2 ZNF543 NOTCH2

2.52e-0518653int:ZNF708
InteractionZFP41 interactions

FBN1 LRP1 LTBP1 NOTCH2

3.42e-0557654int:ZFP41
InteractionRIPPLY2 interactions

TLE2 TLE3 TLE4

3.51e-0520653int:RIPPLY2
InteractionLAMA2 interactions

FBN1 LAMA2 LTBP1

5.42e-0523653int:LAMA2
InteractionST14 interactions

FBN1 LAMB1 PLAT ADAM10 NOTCH2 TMEM106A

5.45e-05207656int:ST14
InteractionFBN2 interactions

FBN1 LTBP1 LTBP2 NOTCH2

5.76e-0565654int:FBN2
InteractionNTN5 interactions

FBN1 LTBP1 NOTCH2

6.18e-0524653int:NTN5
Cytoband19q13.43

ZNF544 ZNF470 ZNF543 ZNF418

8.42e-068767419q13.43
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF132 ZNF544 ZNF283 LRP3 ZNF470 ZNF350 ZNF543 ZNF418 LGI4

5.76e-051192679chr19q13
Cytoband14q24.2

PCNX1 ZFYVE1

6.16e-042567214q24.2
Cytoband15q22

TLE3 ADAM10

8.30e-042967215q22
Cytoband19q13.11

LRP3 LGI4

1.99e-034567219q13.11
CytobandEnsembl 112 genes in cytogenetic band chr14q24

PCNX1 LTBP2 ZFYVE1

3.18e-03200673chr14q24
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZSCAN29 ZNF132 ZNF22 SALL1 ZNF33A ZNF544 ZNF283 ZNF470 ZNF350 ZNF543 ZNF679 ZNF418 ZNF709

2.93e-08718481328
GeneFamilyLaminin subunits

LAMA2 LAMA4 LAMB1

3.80e-0612483626
GeneFamilyLow density lipoprotein receptors

LRP1 LRP3 LRP8

4.93e-0613483634
GeneFamilyLatent transforming growth factor beta binding proteins

LTBP1 LTBP2

4.13e-054482628
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ADAM7 ADAM10

2.32e-032748247
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

STAB2 MEGF10

2.32e-03274821253
CoexpressionNABA_ECM_GLYCOPROTEINS

FBN1 VWF LAMA2 LAMA4 LAMB1 LTBP1 LTBP2 LGI4 USH2A FBN3

6.37e-111966610M3008
CoexpressionNABA_MATRISOME

FBN1 VWF WNT2 ADAM7 WIF1 LAMA2 LAMA4 ADAMTS18 LAMB1 PLAT LTBP1 LTBP2 LGI4 ADAM10 USH2A FBN3 MEGF10

4.30e-1010266617M5889
CoexpressionNABA_ECM_GLYCOPROTEINS

FBN1 VWF OTOGL LAMA2 LAMA4 LAMB1 LTBP1 LTBP2 LGI4

1.24e-09191669MM17059
CoexpressionNABA_CORE_MATRISOME

FBN1 VWF LAMA2 LAMA4 LAMB1 LTBP1 LTBP2 LGI4 USH2A FBN3

1.73e-092756610M5884
CoexpressionNABA_MATRISOME

FBN1 VWF OTOGL WNT2 ADAM7 WIF1 LAMA2 LAMA4 ADAMTS18 LAMB1 PLAT LTBP1 LTBP2 LGI4 ADAM10 MEGF10

2.86e-0910086616MM17056
CoexpressionNABA_CORE_MATRISOME

FBN1 VWF OTOGL LAMA2 LAMA4 LAMB1 LTBP1 LTBP2 LGI4

2.53e-08270669MM17057
CoexpressionCLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN

FBN1 LAMA2 LTBP1 LTBP2

1.81e-0635664M11788
CoexpressionCLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN

FBN1 LAMA2 LTBP1 LTBP2

2.03e-0636664MM1212
CoexpressionNABA_BASEMENT_MEMBRANES

LAMA2 LAMA4 LAMB1 USH2A

3.13e-0640664M5887
CoexpressionVERRECCHIA_EARLY_RESPONSE_TO_TGFB1

LRP1 LAMA4 PLAT NOTCH2

1.05e-0554664M4737
CoexpressionGSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_60H_DN

FBN1 UBE3A ADAM7 LTBP2 LGI4 NOTCH2

1.14e-05200666M9657
CoexpressionGRUETZMANN_PANCREATIC_CANCER_UP

FBN1 WNT2 LAMA4 PLAT LTBP1 ADAM10 TFF1

3.32e-05359667M15193
CoexpressionHEVNER_CORTEX_COMMITTED_TO_CORTICOTHALAMIC_PROJECTION_NEURON_FATE

TLE4 ADAMTS18 PCNX1

3.37e-0525663MM424
CoexpressionGAO_LARGE_INTESTINE_ADULT_CJ_IMMUNE_CELLS

FBN1 VWF SALL1 LRP1 LAMA4 PLAT LTBP2 LGI4

3.87e-05505668M39167
CoexpressionVART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP

STAB2 WNT2 PLAT DLL1 NOTCH2

5.75e-05163665M12112
CoexpressionHALLMARK_NOTCH_SIGNALING

WNT2 DLL1 NOTCH2

7.18e-0532663M5903
CoexpressionCHICAS_RB1_TARGETS_CONFLUENT

KCNMB2 FBN1 LMO7 WNT2 LAMA4 CORIN LTBP2 NOTCH2

8.70e-05567668M2129
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP

LMO7 TLE2 PCNX1 PLAT LTBP2

1.02e-04184665M8544
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP

LMO7 TLE2 PCNX1 PLAT LTBP2

1.13e-04188665MM983
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HRGL2A

SALL1 NRXN1 RANBP3L TLE2 LRP1 LAMA4 LTBP1 NOTCH2

1.29e-04600668M39055
CoexpressionIZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_DN

FBN1 LAMA4 LAMB1 LTBP2

1.56e-04107664M4913
CoexpressionCUI_DEVELOPING_HEART_C3_FIBROBLAST_LIKE_CELL

FBN1 LRP1 LAMA4 LAMB1

2.20e-04117664M39300
CoexpressionLIU_PROSTATE_CANCER_DN

FBN1 WFDC2 TLE2 WIF1 LAMA4 LAMB1 LTBP1

2.38e-04493667M19391
CoexpressionAIZARANI_LIVER_C33_STELLATE_CELLS_2

NRXN1 LAMB1 PLAT LGI4

2.91e-04126664M39132
CoexpressionMURARO_PANCREAS_MESENCHYMAL_STROMAL_CELL

FBN1 LAMA2 LAMA4 LAMB1 PLAT LTBP1 LTBP2 NOTCH2

3.03e-04681668M39175
CoexpressionDESCARTES_FETAL_ADRENAL_SCHWANN_CELLS

NRXN1 WFDC2 LGI4 MEGF10

3.28e-04130664M40147
CoexpressionAtlasStromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3

FBN1 LAMA2 LAMA4 LAMB1 PLAT LTBP1

5.66e-0797666GSM777043_100
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#2_top-relative-expression-ranked_1000

HOXA13 SALL1 LMO7 TLE4 WIF1 ADAMTS18 LTBP1 MEGF10 LRP8

2.42e-06377669gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder mesenchyme_emap-3087_top-relative-expression-ranked_100

HOXA13 VWF WNT2 LAMA4 MEGF10

7.13e-0686665gudmap_developingLowerUrinaryTract_e13.5_bladder mesenchyme_100
CoexpressionAtlasDevelopingKidney_e13.5_podocyte cells_emap-27773_top-relative-expression-ranked_500

STAB2 SALL1 LAMA4 ADAMTS18 CORIN PLAT DLL1 MEGF10 LRP8

7.15e-06431669gudmap_developingKidney_e13.5_podocyte cells_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#5_top-relative-expression-ranked_500

HOXA13 SALL1 LMO7 WIF1 LTBP1 MEGF10

5.79e-05217666gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_500_k5
CoexpressionAtlasDevelopingKidney_e12.5_renal vesicle_emap-27679_top-relative-expression-ranked_100

SALL1 WFDC2 LTBP1 DLL1

9.23e-0576664gudmap_developingKidney_e12.5_renal vesicle_100
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#4_top-relative-expression-ranked_1000

SALL1 TLE4 WIF1 ADAMTS18 MEGF10

9.45e-05147665DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k4_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_top-relative-expression-ranked_1000

HOXA13 SALL1 LMO7 TLE4 WIF1 LAMA4 ADAMTS18 LTBP1 MEGF10 LRP8

1.23e-047696610gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_top-relative-expression-ranked_200

HOXA13 SALL1 LMO7 WIF1 MEGF10

1.29e-04157665gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_200
CoexpressionAtlasDevelopingKidney_e11.5_metaneph mesench_emap-3843_top-relative-expression-ranked_100

KCNMB2 SALL1 ADAMTS18 LRP8

1.43e-0485664gudmap_developingKidney_e11.5_metaneph mesench_100
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_1000

FBN1 SALL1 WFDC2 LAMA4 LAMB1 CORIN PLAT LTBP1 DLL1 NOTCH2

1.43e-047836610gudmap_kidney_P4_CapMesRenVes_Crym_1000
CoexpressionAtlasDevelopingKidney_e12.5_renal vesicle_emap-27679_top-relative-expression-ranked_200

SALL1 WFDC2 LTBP1 DLL1 LRP8

1.45e-04161665gudmap_developingKidney_e12.5_renal vesicle_200
CoexpressionAtlaskidney_P3_CapMes_Crym_top-relative-expression-ranked_500

KCNMB2 SALL1 WFDC2 LAMA4 LAMB1 LTBP1 NOTCH2

1.48e-04370667gudmap_kidney_P3_CapMes_Crym_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder mesenchyme_emap-3087_top-relative-expression-ranked_200

HOXA13 VWF WNT2 LAMA4 MEGF10

1.67e-04166665gudmap_developingLowerUrinaryTract_e13.5_bladder mesenchyme_200
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_200

HOXA13 WNT2 LAMA4 LTBP1 MEGF10

1.67e-04166665gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_200
CoexpressionAtlaskidney_P3_CapMes_Crym_top-relative-expression-ranked_200

SALL1 WFDC2 LAMA4 LTBP1 NOTCH2

1.67e-04166665gudmap_kidney_P3_CapMes_Crym_200
CoexpressionAtlasDevelopingKidney_e13.5_podocyte cells_emap-27773_top-relative-expression-ranked_200

SALL1 LAMA4 CORIN DLL1 MEGF10

1.87e-04170665gudmap_developingKidney_e13.5_podocyte cells_200
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_top-relative-expression-ranked_500

HOXA13 SALL1 LMO7 WIF1 LAMA4 LTBP1 MEGF10

2.05e-04390667gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_k-means-cluster#5_top-relative-expression-ranked_200

SALL1 WIF1 MEGF10

2.07e-0437663gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_200_k5
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_500

SALL1 WFDC2 LAMA4 LAMB1 LTBP1 DLL1 NOTCH2

2.32e-04398667gudmap_kidney_P4_CapMesRenVes_Crym_500
CoexpressionAtlasDevelopingKidney_e11.5_ureteric bud_emap-3844_k-means-cluster#1_top-relative-expression-ranked_200

ADAMTS18 LRP8

2.63e-048662gudmap_developingKidney_e11.5_ureteric bud_200_k1
CoexpressionAtlaskidney_P2_CapMes_Crym_top-relative-expression-ranked_500

KCNMB2 SALL1 WFDC2 LAMA4 LTBP1 NOTCH2

2.87e-04291666gudmap_kidney_P2_CapMes_Crym_500
CoexpressionAtlasDevelopingKidney_e13.5_podocyte cells_emap-27773_top-relative-expression-ranked_1000

STAB2 SALL1 LAMA4 ADAMTS18 CORIN PLAT LTBP1 DLL1 MEGF10 LRP8

2.90e-048556610gudmap_developingKidney_e13.5_podocyte cells_1000
CoexpressionAtlasDevelopingKidney_e15.5_Podocyte cells_emap-27915_top-relative-expression-ranked_500

SALL1 LAMA4 CORIN PLAT LTBP1 DLL1 MEGF10

2.99e-04415667gudmap_developingKidney_e15.5_Podocyte cells_500
CoexpressionAtlasECTO blastocyst_vs_ECTO cord blood-Confounder_removed-fold2.0_adjp0.05

WFDC2 LTBP1 LTBP2 DLL1 FBN3

3.05e-04189665PCBC_ratio_ECTO blastocyst_vs_ECTO cord blood_cfr-2X-p05
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_top-relative-expression-ranked_500

HOXA13 SALL1 WNT2 WIF1 ADAMTS18 MEGF10 LRP8

3.40e-04424667gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#3_top-relative-expression-ranked_1000

SALL1 WIF1 ADAMTS18 MEGF10 LRP8

3.61e-04196665DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k3_1000
CoexpressionAtlasStromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4

FBN1 LRP1 LAMA2 LAMA4 LAMB1 PLAT LTBP1

4.08e-04437667GSM777046_500
CoexpressionAtlaskidney_P2_CapMes_Crym_k-means-cluster#3_top-relative-expression-ranked_500

KCNMB2 SALL1 LAMA4 LTBP1 NOTCH2

4.14e-04202665gudmap_kidney_P2_CapMes_Crym_k3_500
CoexpressionAtlasStromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4

STAB2 FBN1 LAMA4 LAMB1 PLAT LTBP1 LTBP2

4.19e-04439667GSM777059_500
CoexpressionAtlasStromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3

FBN1 LRP1 LAMA2 LAMA4 LAMB1 PLAT LTBP1

4.54e-04445667GSM777043_500
CoexpressionAtlasStromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4

STAB2 FBN1 LAMA4 LAMB1 PLAT LTBP1 LTBP2

4.86e-04450667GSM777063_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_k-means-cluster#3_top-relative-expression-ranked_1000

SALL1 LMO7 WIF1 LTBP1

5.01e-04118664gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_1000_k3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_k-means-cluster#4_top-relative-expression-ranked_200

LMO7 WIF1 MEGF10

5.68e-0452663gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_200_k4
CoexpressionAtlasgudmap_RNAseq_e15.5_Podocytes_2500_K0

KCNMB2 STAB2 FBN1 VWF SALL1 LAMA4 CORIN PLAT LTBP1 PRKCSH SSH2

7.36e-0411436611gudmap_RNAseq_e15.5_Podocytes_2500_K0
CoexpressionAtlasplacenta

HOXA13 FBN1 WNT2 LAMA2 ADAMTS18 LAMB1

7.48e-04349666placenta
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_1000

HOXA13 SALL1 WNT2 TLE4 WIF1 LAMA4 ADAMTS18 ADAM10 MEGF10

8.33e-04806669DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_1000
CoexpressionAtlasDevelopingKidney_e11.5_metaneph mesench_emap-3843_k-means-cluster#1_top-relative-expression-ranked_100

ADAMTS18 LRP8

8.45e-0414662gudmap_developingKidney_e11.5_metaneph mesench_100_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_1000

HOXA13 SALL1 UBE3A WNT2 WIF1 LAMA4 ADAMTS18 MEGF10 LRP8

9.25e-04818669DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_1000
CoexpressionAtlaskidney_P2_CapMes_Crym_top-relative-expression-ranked_200

KCNMB2 SALL1 WFDC2 LAMA4

9.25e-04139664gudmap_kidney_P2_CapMes_Crym_200
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_top-relative-expression-ranked_1000

KCNMB2 HOXA13 SALL1 LMO7 WNT2 WIF1 ADAMTS18 MEGF10 LRP8

9.99e-04827669gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_500

HOXA13 LTBP1 MEGF10

1.04e-0364663gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500_k4
CoexpressionAtlaskidney_P3_CapMes_Crym_k-means-cluster#4_top-relative-expression-ranked_200

LAMA4 LTBP1 NOTCH2

1.09e-0365663gudmap_kidney_P3_CapMes_Crym_k4_200
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#5_top-relative-expression-ranked_200

SALL1 LMO7 WIF1

1.09e-0365663gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_200_k5
CoexpressionAtlasDevelopingKidney_e12.5_renal vesicle_emap-27679_k-means-cluster#2_top-relative-expression-ranked_500

SALL1 LAMA4 LTBP1 DLL1

1.17e-03148664gudmap_developingKidney_e12.5_renal vesicle_500_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#4_top-relative-expression-ranked_500

SALL1 WIF1 MEGF10

1.19e-0367663DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k4_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_top-relative-expression-ranked_1000

HOXA13 SALL1 LMO7 WNT2 WIF1 LAMB1 LTBP1 MEGF10 LRP8

1.21e-03850669gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000
ToppCell356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|356C / Donor, Lineage, Cell class and subclass (all cells)

KCNMB2 FBN1 WNT2 LAMA2 LAMA4 LAMB1 PLAT LTBP1

2.31e-10177668cdfd2f0ee2f692271b1525e414b0f645cdadb1f6
ToppCell356C-Fibroblasts-Fibroblast-C_(Myofibroblast)|356C / Donor, Lineage, Cell class and subclass (all cells)

KCNMB2 FBN1 WNT2 LAMA2 LAMA4 LAMB1 PLAT LTBP1

2.31e-10177668db222faaecbe5600da39277243c4e7e764eb63c9
ToppCellBiopsy_Control_(H.)-Mesenchymal-Myofibroblasts|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

FBN1 RANBP3L WNT2 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

5.86e-101996687a227c239afdaebcac84644d9b2653a5f1a4be71
ToppCellcellseq-Mesenchymal|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2 LGI4

6.10e-10200668238285fc372ce2e5e4341fc3084a3a833bf4a0a6
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 LRP1 LAMA2 LAMB1 CORIN LTBP1 LTBP2 DLL1

6.10e-102006688ab0051544ea32eb8b3f7f8ba7582deaf8bf26c0
ToppCellBiopsy_IPF-Mesenchymal-Myofibroblasts|Biopsy_IPF / Sample group, Lineage and Cell type

FBN1 WNT2 LAMA2 LAMA4 LAMB1 CORIN LTBP1 LTBP2

6.10e-10200668c2c6f687c49ba790174b27c7b8b084af30b34c86
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 LRP1 LAMA2 LAMA4 LAMB1 CORIN LTBP1 LTBP2

6.10e-1020066858b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.26e-08188667038f48e8daaeb72716e975d22a6b004a90654960
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 WNT2 LRP1 LAMA2 LAMA4 LAMB1 PLAT

1.30e-08189667bc54ffd7bd1627a36747a80ce5139e4a69928400
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 WNT2 LRP1 LAMA2 LAMA4 LAMB1 PLAT

1.35e-08190667f3ca94a31a35eed5fecf3c4b8c957e1bc4150158
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 WNT2 LRP1 LAMA2 LAMA4 LAMB1 PLAT

1.35e-08190667c2cd1eb674162ee40502c3380b7245c85079c7ce
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 WNT2 LRP1 LAMA2 LAMA4 LAMB1 LTBP1

1.40e-08191667094c9d3270fc1e487ccf10fb4936af5f081f6009
ToppCellfacs-Lung-24m-Mesenchymal|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 WNT2 LRP1 LAMA2 LAMA4 LAMB1 LTBP1

1.40e-08191667ba02cbdfda6a94374a6472eb88499059979af472
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 LRP1 LAMA2 LAMA4 LAMB1 PLAT LTBP1

1.45e-08192667321850b0f881420c2d57d3e825e365c82fa511ab
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_2-SCMF|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FBN1 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2 MEGF10

1.45e-0819266767e845e513e76e820f55e2f0d15eb16f2944d05c
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FBN1 RANBP3L LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.45e-0819266799ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 LRP1 LAMA2 LAMA4 LAMB1 PLAT LTBP1

1.45e-08192667cf2765d8bc074f7f9ee864eae632a3b705175842
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.51e-08193667b05361ffe111a38cfa26eb86e4ae62c15ac99b7b
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D231|Adult / Lineage, Cell type, age group and donor

FBN1 RANBP3L WNT2 LAMA2 LAMA4 LAMB1 LTBP2

1.51e-08193667ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 WNT2 LRP1 LAMA2 LAMA4 LAMB1 PLAT

1.56e-081946677b6ec45adb7ece3c8a7b78c5782413b5825effe2
ToppCell(5)_Fibroblast-C_(Myofibroblast)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.56e-0819466729a72e565c19407bbd198cfbc2a78106fe830d05
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 WNT2 LRP1 LAMA2 LAMA4 LAMB1 LTBP2

1.62e-08195667df409f94f4e83be89f7a608058ee07ce3ce3a149
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell|Adult / Lineage, Cell type, age group and donor

FBN1 RANBP3L WNT2 LAMA2 LAMA4 LAMB1 LTBP2

1.62e-0819566761c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 WNT2 LRP1 LAMA2 LAMA4 LAMB1 LTBP2

1.62e-081956674243190ad291d56694e2155954dbaa879c9d3844
ToppCellfacs-SCAT-Fat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 WNT2 LRP1 LAMA2 LAMB1 PLAT LTBP1

1.68e-0819666765f2f51e17f1869f3468813127b96d3048d8ad41
ToppCellfacs-SCAT-Fat-18m-Mesenchymal-mesenchymal_progenitor|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 WNT2 LRP1 LAMA2 LAMB1 PLAT LTBP1

1.68e-08196667e4ed897900a6472738bc6be2fb4817192727225d
ToppCellIPF-Stromal-Myofibroblast|IPF / Disease state, Lineage and Cell class

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.68e-081966672d0a48e49b3b37bb66e33e74c52915911e1f8a74
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 WNT2 LRP1 LAMA2 LAMA4 LAMB1 LTBP2

1.68e-0819666742e9828222a9663525d571633e8a454c30bfa7f8
ToppCellfacs-SCAT-Fat-18m-Mesenchymal|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 WNT2 LRP1 LAMA2 LAMB1 PLAT LTBP1

1.68e-081966672cd83176f2e8a9e6fa3c08cb33928a61e5fc43b6
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RANBP3L WNT2 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.74e-0819766794a9603cbd3516fbcce871909693b88f20d41713
ToppCelltumor_Lung-Fibroblasts-COL13A1+_matrix_FBs|tumor_Lung / Location, Cell class and cell subclass

FBN1 WNT2 LRP1 LAMA2 LAMA4 LTBP1 LTBP2

1.80e-081986672d7842f352273b6b823c86eb548b9f4a4cddf0ae
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)|367C / Donor, Lineage, Cell class and subclass (all cells)

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.80e-08198667a9afedbc0556faf4a46f7bf28f4a9adb3bc859d8
ToppCelltumor_Lung-Fibroblasts-Myofibroblasts|tumor_Lung / Location, Cell class and cell subclass

FBN1 WNT2 LRP1 LAMA4 LAMB1 LTBP1 LTBP2

1.80e-0819866731f9181dab689aabe9c6182c2ef7de65ba3f0ff6
ToppCellfacs-Trachea-nan-3m-Mesenchymal-fibroblast|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 LRP1 LAMA2 LAMA4 LAMB1 PLAT LTBP1

1.80e-081986670dc7d59a07428a7b7e8bdc81f0e2417dd4ce3cf2
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|367C / Donor, Lineage, Cell class and subclass (all cells)

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.80e-081986677b5350768f306ec528e271d2ac4470bf668ec6f0
ToppCell5'-Parenchyma_lung-Mesenchymal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2 LGI4

1.80e-08198667aae663c6da70b6e716edeed50cc7d3962d78e697
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 SALL1 LAMA4 LAMB1 PLAT DLL1 TCTN1

1.86e-0819966730ab0750d51f168b18c434c974d24a4e70f29cc7
ToppCellmetastatic_Brain-Fibroblasts-FB-like_cells|metastatic_Brain / Location, Cell class and cell subclass

FBN1 RANBP3L WNT2 LAMA2 LAMA4 LAMB1 LTBP2

1.86e-0819966712133087eae9f0e9b6c13a71e8187117768e64ce
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.86e-081996670019cfaa586a450c2e4952d1184a540561c8d0ba
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 LRP1 LAMA2 LAMA4 CORIN LTBP1 LTBP2

1.86e-08199667fb580e9321ddf97c73b2e356cd82523db74a38a2
ToppCellBiopsy_Other_PF-Mesenchymal-Myofibroblasts|Biopsy_Other_PF / Sample group, Lineage and Cell type

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.93e-08200667e504570fd7eec1524c401b1cfa9d10822d80d994
ToppCellcellseq-Mesenchymal-Fibroblastic|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.93e-082006678978867bf69c830b1e48cac2ad6b512dbe60f149
ToppCellBiopsy_Control_(H.)-Mesenchymal|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

FBN1 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2 LGI4

1.93e-0820066701522ed0b68614b1ebdf190957d44a9d48a6c6e3
ToppCell390C-Fibroblasts-Fibroblast-H-|390C / Donor, Lineage, Cell class and subclass (all cells)

FBN1 WNT2 LRP1 LAMA2 LAMA4 LAMB1 LTBP2

1.93e-08200667ec7d6a08e34bcad5b3bbff56ebef96ae17e4cefd
ToppCellBronchial-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 LRP1 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.93e-08200667389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 RANBP3L LRP1 LAMA2 LAMA4 LAMB1 LTBP2

1.93e-08200667e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCell3'-Parenchyma_lung-Mesenchymal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.93e-08200667ba5ed66b05caa1be0bbf8d54c4e72a782b8d9833
ToppCellParenchymal-10x5prime-Stromal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.93e-082006672e525c0d9684e7a2275edb04e1addb6fc6a872e5
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

FBN1 WIF1 LRP1 LAMA4 LAMB1 LTBP1 LTBP2

1.93e-08200667a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FBN1 LRP1 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.93e-0820066709537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 WNT2 LRP1 LAMA2 LAMA4 LTBP1 LTBP2

1.93e-082006672e4ab7fbd94d3d865ef6188d3b4916d2bf1b8d89
ToppCellParenchymal-10x5prime-Stromal-Fibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.93e-082006676e3d1ae0ef84d3075afa40129a41169996462672
ToppCellTracheal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 LRP1 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.93e-08200667b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCellParenchymal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 LRP1 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.93e-08200667cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCellBronchial-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 LRP1 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.93e-08200667cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 LRP1 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.93e-082006673dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCellTracheal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 LRP1 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.93e-08200667c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCellBiopsy_IPF-Mesenchymal|Biopsy_IPF / Sample group, Lineage and Cell type

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.93e-08200667bb605b373caf3f873dc1b87d712704568e0d6040
ToppCelltumor_Lung-Fibroblasts|tumor_Lung / Location, Cell class and cell subclass

FBN1 WNT2 LRP1 LAMA2 LAMA4 LTBP1 LTBP2

1.93e-08200667073a68b5ce232203ffee86342cba2a00d907e119
ToppCellParenchymal-10x3prime_v2-Stromal-Fibroblastic-Fibro_peribronchial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 LRP1 LAMA2 LAMB1 CORIN LTBP1 LTBP2

1.93e-08200667efdf7066b7dd43e35dbc0d2719b75f250cf54af2
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 LRP1 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

1.93e-08200667311fab076f2ceb258e3970eb21e39344b894042a
ToppCell390C-Fibroblasts-Fibroblast-H|390C / Donor, Lineage, Cell class and subclass (all cells)

FBN1 WNT2 LRP1 LAMA2 LAMA4 LAMB1 LTBP2

1.93e-08200667671e731977c58a0c44c36b56422085d93d999aad
ToppCellAdult-Mesenchymal-chondrocyte-D231|Adult / Lineage, Cell type, age group and donor

KCNMB2 FBN1 LAMA2 LAMA4 LAMB1 LTBP2

1.62e-071646662ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 LRP1 LAMA2 LAMA4 LTBP1 LTBP2

2.38e-07175666795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 LRP1 LAMA2 CORIN LTBP1 LTBP2

2.46e-071766669bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 LRP1 LAMA2 CORIN LTBP1 LTBP2

2.46e-071766663f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCellmetastatic_Brain-Fibroblasts-Myofibroblasts|metastatic_Brain / Location, Cell class and cell subclass

FBN1 WNT2 LAMB1 CORIN LTBP1 LTBP2

2.90e-07181666bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

FBN1 RANBP3L WNT2 LAMA2 LAMA4 LAMB1

2.90e-071816669ede19228ba5c0668a9c06c915510b95585216ef
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

FBN1 VWF LAMA2 LAMB1 LTBP1 LTBP2

3.00e-07182666fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

3.30e-0718566687c416d14ca6255bee39b16e7571553e36ee3069
ToppCelldroplet-Fat-Scat-21m-Mesenchymal-Cd34+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 WFDC2 WNT2 LAMA2 LAMB1 PLAT

3.30e-0718566601bbe1e09f9ccae837a03ea2cdd168fa10800942
ToppCellCOVID-19-Heart-Fib_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

FBN1 LRP1 LAMA2 LAMB1 LTBP1 LTBP2

3.30e-071856668f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCell(0)_MSCs|World / Cell class and subclass of bone marrow stroma cells in homeostatis

FBN1 LMO7 TLE2 LAMB1 LTBP1 LTBP2

3.40e-07186666a832c1e0035bcd559722eccf262c145deb3494c7
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP2

3.40e-071866665473283fb95cee556b1f6934cf72169b676b5bcc
ToppCell(0)_MSCs-(00)_Lepr-MSC|World / Cell class and subclass of bone marrow stroma cells in homeostatis

FBN1 LMO7 TLE2 LAMB1 LTBP1 LTBP2

3.40e-07186666f0d156167d7cc2cd8a76e5a364233e9f2170bc01
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

FBN1 RANBP3L LAMA2 LAMA4 LAMB1 LTBP2

3.51e-0718766692d468dde81125d51daf7abd4703741abe1ab91c
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

FBN1 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

3.51e-07187666bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

FBN1 SALL1 LAMA2 LAMB1 CORIN LTBP2

3.51e-07187666a96495803ba13fcfadd1d83b3cf5774f3fed0a20
ToppCelldroplet-Fat-Scat-21m-Mesenchymal-mesenchymal_stem_cell_of_adipose|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 WFDC2 WNT2 LAMA2 LAMB1 PLAT

3.63e-07188666e54e09d34e263d5709c337914809e61e74e20591
ToppCellP15-Mesenchymal|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FBN1 WNT2 LRP1 LAMA2 LAMA4 LAMB1

3.63e-07188666f1ba0b661621a65c91432e62ba73531bdf18e7c1
ToppCelldroplet-Fat-Scat-21m-Mesenchymal|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 WFDC2 WNT2 LAMA2 LAMB1 PLAT

3.63e-071886667fc9810ab14354cb512e2b1285562009c10203f5
ToppCellCOVID-19-Heart-Fib_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

FBN1 LRP1 LAMA2 LAMB1 LTBP1 LTBP2

3.63e-07188666fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCellfacs-Lung-18m-Mesenchymal|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 WNT2 LRP1 LAMA2 LAMA4 LAMB1

3.74e-07189666bdf8db938aa0863c4fed6fa99dcffd63c8c20c31
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 WNT2 LRP1 LAMA2 LAMB1 PLAT

3.86e-07190666bd0d68dc1b6f388190a6ba8a83b011619abe2bdd
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 WNT2 LRP1 LAMA2 LAMB1 PLAT

3.86e-07190666e275de94468872e70cf305b3b450823d4c9c5e3f
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NRXN1 LAMA2 LAMA4 LAMB1 PLAT LTBP2

3.86e-071906661004e89d99c9d46c78b7d3532d8d4aadb81a96fd
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 WNT2 LRP1 LAMA2 LAMB1 PLAT

3.86e-07190666ee2f4a55d2fd18b83e55399b5b5697a15a2d2e70
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NRXN1 LAMA2 LAMA4 LAMB1 PLAT LTBP2

3.86e-07190666951e067d14412db67dc3babcdf61e41717d7b429
ToppCellP03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NRXN1 LAMA2 LAMB1 PLAT LTBP2 NOTCH2

3.86e-07190666979b1476fd2692fde977ce56257315fcfc8a01d5
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

FBN1 LAMA2 LAMA4 LAMB1 LTBP1 LTBP2

3.86e-071906663a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NRXN1 LAMA2 LAMA4 LAMB1 PLAT LTBP2

3.86e-0719066610b02c62e72bfea9767e3e751011436925da823e
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP1

3.98e-07191666ce80f65bd24b1c4d2152bf45248449e7a1a97e56
ToppCellASK454-Mesenchymal|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

FBN1 LAMA2 LAMA4 LAMB1 LTBP2 LGI4

3.98e-07191666e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCellASK454-Mesenchymal-Fibroblast|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

FBN1 LAMA2 LAMA4 LAMB1 LTBP2 LGI4

3.98e-071916661726add3f392a061536b7aff72ba84303f4a0b1f
ToppCell10x5'v1-week_17-19-Endothelial-stroma-proliferating_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

STAB2 VWF LAMA4 ADAMTS18 LAMB1 PLAT

3.98e-07191666dc9e5eb6aa31b8d79aeec33e59b9138dfb469a3b
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 LRP1 LAMA2 LAMA4 LAMB1 LTBP1

3.98e-07191666997abf0cc5873bed0372c4a333ed307fa72774d2
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FBN1 RANBP3L LAMA2 LAMA4 LAMB1 LTBP2

3.98e-071916666688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCelldroplet-Lung-1m-Mesenchymal|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 WNT2 LAMA2 LAMA4 LAMB1 LTBP1

4.10e-0719266601433bd4794b8bcc51fe4249124a0f4289b9d6e2
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 LRP1 LAMA2 LAMA4 LAMB1 PLAT

4.10e-07192666beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

FBN1 VWF LRP1 LAMA2 LAMB1 LTBP2

4.10e-0719266660b1312e84f6d6448365a952469c506c00b5fe93
ComputationalAdhesion molecules.

FBN1 VWF WNT2 LAMA2 LAMA4 LAMB1

1.63e-05141426MODULE_122
ComputationalDRG (dorsal root ganglia) genes.

FBN1 VWF TLE2 LRP1 LAMA4 LAMB1 LTBP1 LTBP2

1.00e-04384428MODULE_2
ComputationalECM and collagens.

FBN1 VWF LRP1 LAMB1 LTBP1 LTBP2

2.20e-04225426MODULE_47
ComputationalOvary genes.

FBN1 VWF LRP1 LAMB1 PLAT LTBP1 LTBP2

4.99e-04368427MODULE_1
DrugIfosfamide [3778-73-2]; Down 200; 15.4uM; PC3; HT_HG-U133A

WFDC2 LMO7 LRP3 LAMA4 PCNX1 ZNF350 ADAM10

1.65e-061976675805_DN
DrugAC1L1G72

LAMA2 LAMA4 LAMB1

3.78e-0611663CID000003553
DiseaseIntracranial Thrombosis

VWF PLAT

1.34e-053632C0752143
DiseaseBrain Thrombosis

VWF PLAT

1.34e-053632C0752144
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN3

1.34e-053632DOID:65 (implicated_via_orthology)
DiseaseWeill-Marchesani syndrome

FBN1 LTBP2

1.34e-053632C0265313
DiseaseWeill-Marchesani Syndrome, Autosomal Dominant

FBN1 LTBP2

1.34e-053632C1869115
DiseaseWeill-Marchesani Syndrome, Autosomal Recessive

FBN1 LTBP2

1.34e-053632C1869114
DiseaseCerebral Thrombosis

VWF PLAT

1.34e-053632C0079102
DiseaseBrain Thrombus

VWF PLAT

1.34e-053632C0936261
DiseaseCerebral Thrombus

VWF PLAT

1.34e-053632C0936263
DiseaseWeill-Marchesani syndrome

FBN1 LTBP2

2.68e-054632cv:C0265313
Diseasevon Willebrand's disease 1 (is_implicated_in)

VWF PLAT

2.68e-054632DOID:0060573 (is_implicated_in)
DiseaseWeill-Marchesani syndrome (is_implicated_in)

FBN1 LTBP2

2.68e-054632DOID:0050475 (is_implicated_in)
DiseaseMalignant neoplasm of breast

ZNF22 VWF OTOGL TLE3 UBR4 LAMA2 USP54 DLL1 ADAM10 NOTCH2

8.67e-0510746310C0006142
DiseaseStage IV Skin Melanoma

ADAM7 ADAM10

9.36e-057632C1321872
Diseasemesangial proliferative glomerulonephritis (biomarker_via_orthology)

FBN1 VWF

1.25e-048632DOID:4783 (biomarker_via_orthology)
Diseaseaortic aneurysm

FBN1 LRP1

2.00e-0410632EFO_0001666
DiseaseAutistic Disorder

NRXN1 UBE3A WNT2 LAMB1 DLL1

2.41e-04261635C0004352
DiseaseMarfan Syndrome

FBN1 LTBP2

2.44e-0411632C0024796
Diseasefactor VIII measurement, Ischemic stroke

STAB2 VWF

7.49e-0419632EFO_0004630, HP_0002140
Diseaseintraocular pressure measurement

FBN1 RANBP3L LMO7 ADAMTS18 LTBP1 LTBP2

7.57e-04509636EFO_0004695
Diseaseglomerulonephritis (biomarker_via_orthology)

FBN1 LTBP1

8.32e-0420632DOID:2921 (biomarker_via_orthology)
Diseasemyocardial infarction (is_implicated_in)

LRP1 PLAT LRP8

1.26e-0399633DOID:5844 (is_implicated_in)
DiseaseFEV change measurement, response to zileuton

NRXN1 PCNX1

1.30e-0325632EFO_0005921, EFO_0007676
Diseasebone density

HOXA13 TESMIN UBE3A ZNF283 ADAMTS18

1.44e-03388635EFO_0003923
Diseasefactor VIII measurement, von Willebrand factor measurement

STAB2 VWF

1.52e-0327632EFO_0004629, EFO_0004630
DiseaseIschemic stroke, von Willebrand factor measurement

STAB2 VWF

1.88e-0330632EFO_0004629, HP_0002140
Diseasespontaneous coronary artery dissection

FBN1 LRP1

2.00e-0331632EFO_0010820

Protein segments in the cluster

PeptideGeneStartEntry
SQGPCCTAQCAFKSK

ADAM10

506

O14672
LKPGFTCAEGECCES

ADAM7

436

Q9H2U9
TVTKSECCCANPDHG

FBN3

636

Q75N90
DACGVCKGDNSTCKF

ADAMTS18

736

Q8TE60
CGCKNDAVCSPVDGS

MEGF10

456

Q96KG7
DAVCSPVDGSCTCKA

MEGF10

461

Q96KG7
DCAFASCTPGSTCID

NOTCH2

341

Q04721
ITETFNCSFSCGPDC

KCNMB2

91

Q9Y691
CDCKDGSDEPGTAAC

PRKCSH

56

P14314
CGDGSDEIPCNKTAC

LRP1

2591

Q07954
KECCAGPEEKNSCAS

PCNX1

431

Q96RV3
CTCPDGFQLDDNKTC

LTBP1

1186

Q14766
KCSKSCDPGEDCASC

PARG

236

Q86W56
FKCVACECDLGGSSS

LMO7

1641

Q8WWI1
KSCPDGADEKNCFSC

LRP3

441

O75074
DLSSEDPFGCKSCAC

LAMB1

446

P07942
PCNCNSFGSKSFDCE

LAMA2

966

P24043
GCKACNCSTVGSLDF

LAMA2

1056

P24043
SCDCSMTSFSGPLCN

NRXN1

1106

Q9ULB1
IDYCSSSPCSNGAKC

DLL1

406

O00548
CKNSPGSFICECSSE

FBN1

821

P35555
SACCCGSDEDPAASA

CLDN15

181

P56746
PCRSFCEAAKEGCES

CORIN

211

Q9Y5Q5
GVCTNTAGSFSCKDC

LTBP2

1106

Q14767
GTSAGCPFEKCCSTE

ARRDC1-AS1

96

Q9H2J1
CDSGPCKNSGFCSER

CELSR3

1726

Q9NYQ7
TACDICGKTFACQSA

SALL1

1001

Q9NSC2
CPKKTCADSDFTCDN

LRP8

81

Q14114
LNGAFCSKTGTCDCQ

OTOGL

86

Q3ZCN5
GSTCKKCDCSGNSDP

LAMA4

181

Q16363
CCKFPSSQELEDASC

TESMIN

186

Q9Y4I5
SFCSCVPCEGTADAS

TMEM106A

41

Q96A25
CCSAAAGSVGCQVAK

REXO1

1016

Q8N1G1
NCKACDCDTAGSLPG

USH2A

791

O75445
EACTCFNCCSKGPTA

USH2A

4806

O75445
CSCSKDSALCEGSPD

LGI4

31

Q8N135
GAEAAKQCSPCSAAA

HOXA13

146

P31271
VTPSQCANKGCCFDD

TFF1

46

P04155
SDSECADNLKCCSAG

WFDC2

51

Q14508
CCSAGCATFCSLPND

WFDC2

61

Q14508
CATFCSLPNDKEGSC

WFDC2

66

Q14508
PFECCDCGKAFSNSS

ZNF132

486

P52740
ACSQGEVKSCSCDPK

WNT2

126

P09544
EFCSTPACSEGNSDC

PLAT

201

P00750
NEACTNEFCASCPTF

UBE3A

46

Q05086
AQCSQKPCEDSCRSG

VWF

2466

P04275
INGCSSGCCLNESKF

SSH2

551

Q76I76
SGCCLNESKFPLDNC

SSH2

556

Q76I76
SPDSKVCFSCCSDGN

TLE4

586

Q04727
CQPNEDKCSFKSCSS

RANBP3L

196

Q86VV4
SYQCEECGKPFNCSS

ZNF679

211

Q8IYX0
CCCDPDCSSVDFSVF

TCTN1

91

Q2MV58
CCFTTASASFPDECE

ZNF654

86

Q8IZM8
AKKSQDFCCEGCGSA

UBE2J1

141

Q9Y385
ECIECGKAFSDCSSL

ZNF470

341

Q6ECI4
ACETCADDNLFGPSC

STAB2

146

Q8WWQ8
CDKANCSTTCFNGGT

WIF1

241

Q9Y5W5
CKECGKAFDCPSSFQ

ZNF709

366

Q8N972
PDAKVCFSCCSDGNI

TLE3

586

Q04726
RACGEGFCDSCSSKT

ZFYVE1

621

Q9HBF4
SFPSRKMFCQCDSCG

ZNF33A

131

Q06730
FVCSECGKSCSQKSG

ZNF350

346

Q9GZX5
ECSECGKSFPQSCSL

ZNF418

511

Q8TF45
PFECNECGKAFCESA

ZNF543

366

Q08ER8
EKPSVCNQCGKSFSC

ZNF544

351

Q6NX49
PYQCSECGKCFSQSS

ZNF22

166

P17026
CGECGKCFNQSSSLI

ZSCAN29

736

Q8IWY8
SFFCDCGAKEDGSCL

UBR4

1711

Q5T4S7
SGASSPCANTTFCCK

PVRIG

121

Q6DKI7
SPDAKVCFSCCSDGN

TLE2

556

Q04725
CEECGKAFCQPSTLT

ZNF726P1

76

Q15940
ECKECGKAFNCGSSL

ZNF283

516

Q8N7M2
FEQCVCTSCGATSDP

USP54

161

Q70EL1