Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN11A SCN1A SCN2A SCN3A SCN10A	6.38e-07	26	130	5	GO:0005248
GeneOntologyMolecularFunction	sodium channel activity	SCN11A SCN1A SCN2A SCN3A SCN10A	2.20e-05	52	130	5	GO:0005272
GeneOntologyMolecularFunction	transcription termination site sequence-specific DNA binding	XRN2 SETX	4.21e-05	2	130	2	GO:0001147
GeneOntologyMolecularFunction	sodium ion binding	SCN1A SCN2A SCN3A	9.31e-05	14	130	3	GO:0031402
GeneOntologyMolecularFunction	neuregulin receptor activity	ERBB3 ERBB4	1.26e-04	3	130	2	GO:0038131
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	SCN1A SCN2A SCN10A	1.72e-04	17	130	3	GO:0099508
GeneOntologyMolecularFunction	intracellularly calcium-gated channel activity	ANO2 BEST1 ANO8	2.83e-04	20	130	3	GO:0141147
GeneOntologyMolecularFunction	intracellularly calcium-gated chloride channel activity	ANO2 BEST1 ANO8	2.83e-04	20	130	3	GO:0005229
GeneOntologyMolecularFunction	neuregulin binding	ERBB3 ERBB4	6.20e-04	6	130	2	GO:0038132
GeneOntologyMolecularFunction	alkali metal ion binding	SCN1A SCN2A SCN3A	6.28e-04	26	130	3	GO:0031420
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	CYLD USP44 USP51 OTUD6B USP27X	9.02e-04	114	130	5	GO:0004843
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	XRN2 SETX ZCWPW2 RNASE9 AZGP1 FARSB MSH4 DDX55 RUVBL2 THAP9 DHX15 POLR1B	1.04e-03	645	130	12	GO:0140640
GeneOntologyMolecularFunction	deubiquitinase activity	CYLD USP44 USP51 OTUD6B USP27X	1.31e-03	124	130	5	GO:0101005
GeneOntologyMolecularFunction	pattern recognition receptor activity	TLR7 NOD1 TLR4	1.52e-03	35	130	3	GO:0038187
GeneOntologyBiologicalProcess	neuronal action potential	SCN11A GPR35 SCN1A SCN2A SCN3A SCN10A	2.70e-06	63	129	6	GO:0019228
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN11A SCN1A SCN2A SCN3A SCN10A	2.86e-06	36	129	5	GO:0086010
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	SCN11A SCN1A SCN2A SCN3A SCN10A	4.31e-05	62	129	5	GO:0086002
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN11A SCN1A SCN2A SCN3A SCN10A	5.21e-08	17	131	5	GO:0001518
GeneOntologyCellularComponent	sodium channel complex	SCN11A SCN1A SCN2A SCN3A SCN10A	9.42e-07	29	131	5	GO:0034706
GeneOntologyCellularComponent	C-fiber	SCN11A SCN10A	2.32e-04	4	131	2	GO:0044299
Domain	Na_channel_asu	SCN11A SCN1A SCN2A SCN3A SCN10A	3.43e-09	10	128	5	IPR001696
Domain	Na_trans_assoc	SCN11A SCN1A SCN2A SCN3A SCN10A	3.43e-09	10	128	5	IPR010526
Domain	Na_trans_assoc	SCN11A SCN1A SCN2A SCN3A SCN10A	3.43e-09	10	128	5	PF06512
Domain	Na_trans_cytopl	SCN1A SCN2A SCN3A	6.19e-06	6	128	3	PF11933
Domain	Na_trans_cytopl	SCN1A SCN2A SCN3A	6.19e-06	6	128	3	IPR024583
Domain	Channel_four-helix_dom	SCN11A SCN1A SCN2A SCN3A SCN10A	4.40e-05	57	128	5	IPR027359
Domain	-	SCN11A SCN1A SCN2A SCN3A SCN10A	4.40e-05	57	128	5	1.20.120.350
Domain	-	COPE NCF2 RMDN2 TTC3 LRPPRC TRANK1 CTR9 TTC21B	9.12e-05	207	128	8	1.25.40.10
Domain	TPR-like_helical_dom	COPE NCF2 RMDN2 TTC3 LRPPRC TRANK1 CTR9 TTC21B	2.06e-04	233	128	8	IPR011990
Domain	Tyr_kinase_EGF/ERB/XmrK_rcpt	ERBB3 ERBB4	2.77e-04	4	128	2	IPR016245
Domain	ARM-like	DOCK2 DNAJC13 SETX ARFGEF2 XPO4 PSMD1 HEATR5A NCAPD2	5.52e-04	270	128	8	IPR011989
Domain	GF_recep_IV	ERBB3 ERBB4	6.87e-04	6	128	2	PF14843
Domain	GF_recep_IV	ERBB3 ERBB4	6.87e-04	6	128	2	IPR032778
Domain	P-loop_NTPase	DNAH3 SETX DRG2 MSH4 DDX55 RUVBL2 NLRP3 DHX15 NOD1 TRANK1 RRAGA HS2ST1 GNAT3 HS6ST3 DNAH5	7.03e-04	848	128	15	IPR027417
Domain	Recep_L_domain	ERBB3 ERBB4	9.57e-04	7	128	2	PF01030
Domain	Furin-like	ERBB3 ERBB4	9.57e-04	7	128	2	PF00757
Domain	Rcpt_L-dom	ERBB3 ERBB4	9.57e-04	7	128	2	IPR000494
Domain	Furin-like_Cys-rich_dom	ERBB3 ERBB4	9.57e-04	7	128	2	IPR006211
Domain	-	ERBB3 ERBB4	9.57e-04	7	128	2	3.80.20.20
Domain	-	UBR2 DTX1 VPS8 TTC3 CBL USP44 ZFYVE9 USP51 ZFYVE26 KDM7A	1.06e-03	449	128	10	3.30.40.10
Domain	USP_CS	CYLD USP44 USP51 USP27X	1.09e-03	66	128	4	IPR018200
Domain	Ion_trans_dom	SCN11A SCN1A SCN2A SCN3A SCN10A	1.13e-03	114	128	5	IPR005821
Domain	Ion_trans	SCN11A SCN1A SCN2A SCN3A SCN10A	1.13e-03	114	128	5	PF00520
Domain	Znf_RING/FYVE/PHD	UBR2 DTX1 VPS8 TTC3 CBL USP44 ZFYVE9 USP51 ZFYVE26 KDM7A	1.25e-03	459	128	10	IPR013083
Domain	USP_1	CYLD USP44 USP51 USP27X	1.36e-03	70	128	4	PS00972
Domain	UCH	CYLD USP44 USP51 USP27X	1.43e-03	71	128	4	PF00443
Domain	USP_2	CYLD USP44 USP51 USP27X	1.43e-03	71	128	4	PS00973
Domain	USP_3	CYLD USP44 USP51 USP27X	1.51e-03	72	128	4	PS50235
Domain	USP_dom	CYLD USP44 USP51 USP27X	1.51e-03	72	128	4	IPR028889
Domain	Peptidase_C19_UCH	CYLD USP44 USP51 USP27X	1.51e-03	72	128	4	IPR001394
Domain	-	DNAH3 SETX DRG2 MSH4 DDX55 RUVBL2 DHX15 NOD1 TRANK1 RRAGA HS2ST1 GNAT3 DNAH5	1.84e-03	746	128	13	3.40.50.300
Domain	TPR	NCF2 TTC3 TRANK1 CTR9 TTC21B	1.95e-03	129	128	5	SM00028
Domain	Anoctamin	ANO2 ANO8	2.02e-03	10	128	2	PF04547
Domain	Anoctamin	ANO2 ANO8	2.02e-03	10	128	2	IPR007632
Domain	VWFC_2	COL5A2 MUC19 THBS2	2.23e-03	38	128	3	PS50184
Domain	VWC	COL5A2 MUC19 THBS2	2.23e-03	38	128	3	SM00214
Domain	TPR_repeat	NCF2 TTC3 TRANK1 CTR9 TTC21B	2.23e-03	133	128	5	IPR019734
Domain	EGF_dom	CUBN THBS2	2.94e-03	12	128	2	IPR024731
Domain	EGF_3	CUBN THBS2	2.94e-03	12	128	2	PF12947
Domain	Sulfotransfer_2	HS2ST1 HS6ST3	2.94e-03	12	128	2	PF03567
Domain	Sulfotransferase	HS2ST1 HS6ST3	2.94e-03	12	128	2	IPR005331
Domain	VWF_dom	COL5A2 MUC19 THBS2	2.97e-03	42	128	3	IPR001007
Domain	IQ_motif_EF-hand-BS	SCN1A SCN2A SCN3A SCN10A	3.41e-03	90	128	4	IPR000048
Domain	TPR-contain_dom	NCF2 TTC3 TRANK1 CTR9 TTC21B	3.75e-03	150	128	5	IPR013026
Domain	IQ	SCN1A SCN2A SCN3A SCN10A	3.84e-03	93	128	4	PS50096
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DNAH5	4.02e-03	14	128	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DNAH5	4.02e-03	14	128	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DNAH5	4.02e-03	14	128	2	IPR013602
Domain	Znf_UBP	USP44 USP51	4.02e-03	14	128	2	IPR001607
Domain	DHC_N2	DNAH3 DNAH5	4.02e-03	14	128	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH3 DNAH5	4.02e-03	14	128	2	IPR011704
Domain	zf-UBP	USP44 USP51	4.02e-03	14	128	2	PF02148
Domain	MT	DNAH3 DNAH5	4.02e-03	14	128	2	PF12777
Domain	AAA_8	DNAH3 DNAH5	4.02e-03	14	128	2	PF12780
Domain	ZF_UBP	USP44 USP51	4.02e-03	14	128	2	PS50271
Domain	AAA_5	DNAH3 DNAH5	4.02e-03	14	128	2	PF07728
Domain	-	DNAJC13 ARFGEF2 XPO4 PSMD1 HEATR5A NCAPD2	4.30e-03	222	128	6	1.25.10.10
Domain	DHC_fam	DNAH3 DNAH5	4.62e-03	15	128	2	IPR026983
Domain	Dynein_heavy	DNAH3 DNAH5	4.62e-03	15	128	2	PF03028
Domain	Dynein_heavy_dom	DNAH3 DNAH5	4.62e-03	15	128	2	IPR004273
Domain	TPR_REGION	NCF2 TTC3 TRANK1 CTR9 TTC21B	5.60e-03	165	128	5	PS50293
Domain	TPR	NCF2 TTC3 TRANK1 CTR9 TTC21B	5.60e-03	165	128	5	PS50005
Domain	TPR_8	NCF2 CTR9 TTC21B	5.74e-03	53	128	3	PF13181
Domain	LRR_6	NLRP3 NOD1 TLR4	6.36e-03	55	128	3	PF13516
Domain	Furin_repeat	ERBB3 ERBB4	6.64e-03	18	128	2	IPR006212
Domain	FU	ERBB3 ERBB4	6.64e-03	18	128	2	SM00261
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN11A SCN1A SCN2A SCN3A SCN10A	2.16e-06	31	98	5	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN11A SCN1A SCN2A SCN3A SCN10A	2.54e-06	32	98	5	M27455
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN11A SCN1A SCN2A SCN3A SCN10A	9.08e-11	9	132	5	16382098
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	NEB SCN1A SCN2A SCN3A	9.88e-10	5	132	4	1679748
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	NEB SCN1A SCN2A SCN3A	9.88e-10	5	132	4	8812438
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN2A SCN3A SCN10A	2.96e-09	6	132	4	23652591
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN1A SCN2A SCN3A	5.34e-08	3	132	3	23859570
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN1A SCN2A SCN3A	5.34e-08	3	132	3	12610651
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN1A SCN2A SCN3A	5.34e-08	3	132	3	18784617
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN1A SCN2A SCN3A	5.34e-08	3	132	3	17544618
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN1A SCN2A SCN3A	5.34e-08	3	132	3	14973256
Pubmed	Defining the membrane proteome of NK cells.	DOCK2 XRN2 DNAJC13 DRG2 ARFGEF2 FARSB PSMD1 APLP2 COLGALT1 DDX55 CIT CYFIP2 LGALS8 LRPPRC HS2ST1 NCAPD2 STARD3NL ALG6 ACSL5	9.76e-08	1168	132	19	19946888
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN1A SCN2A SCN3A SCN10A	1.38e-07	13	132	4	15123669
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN1A SCN2A SCN3A	2.13e-07	4	132	3	17537961
Pubmed	Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.	SCN1A SCN2A SCN3A	2.13e-07	4	132	3	35801810
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN1A SCN2A SCN3A	2.13e-07	4	132	3	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN1A SCN2A SCN3A	2.13e-07	4	132	3	29578003
Pubmed	Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.	SCN1A SCN2A SCN3A	2.13e-07	4	132	3	8974318
Pubmed	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.	SCN1A SCN2A SCN3A	5.31e-07	5	132	3	24337656
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SETX XPO4 FASTKD2 PLXND1 DDX55 SHISAL1 IBTK TRANK1 SUPT6H HS2ST1 NCAPD2 KDM7A	9.06e-07	529	132	12	14621295
Pubmed	An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.	SCN11A SCN3A SCN10A	1.06e-06	6	132	3	23711479
Pubmed	Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.	NLRP3 NOD1 TLR4	1.06e-06	6	132	3	16984919
Pubmed	LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation.	ERBB3 ERBB4 CBL	1.06e-06	6	132	3	15282549
Pubmed	Pain without nociceptors? Nav1.7-independent pain mechanisms.	SCN11A SCN3A SCN10A	1.85e-06	7	132	3	24440715
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	XRN2 AZGP1 COPE FARSB PSMD1 APLP2 FASTKD2 COLGALT1 DDX55 TTC3 RUVBL2 CYFIP2 DHX15 GLMN LRPPRC CTR9 SUPT6H NCAPD2 DNAH5	1.94e-06	1425	132	19	30948266
Pubmed	Significant determinants of mouse pain behaviour.	SCN11A SCN3A SCN10A	2.95e-06	8	132	3	25101983
Pubmed	TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines.	TLR7 NLRP3 TLR4	2.95e-06	8	132	3	33963333
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN1A SCN2A SCN3A	4.41e-06	9	132	3	15746173
Pubmed	The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands.	TLR7 NOD1 TLR4	6.29e-06	10	132	3	18261938
Pubmed	Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome.	NLRP3 NOD1 TLR4	6.29e-06	10	132	3	22323544
Pubmed	The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.	TLR7 LATS1 TLR4	8.62e-06	11	132	3	27912060
Pubmed	Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling.	NLRP3 NOD1 TLR4	8.62e-06	11	132	3	17433728
Pubmed	Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B.	TLR7 NLRP3 TLR4	8.62e-06	11	132	3	22634614
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	SETX AZGP1 PSMD1 RUVBL2 DHX15 LRPPRC SUPT6H ACSL5	1.01e-05	272	132	8	31010829
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN1A SCN2A SCN3A	1.15e-05	12	132	3	30175250
Pubmed	The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.	TLR7 NLRP3 TLR4	1.15e-05	12	132	3	20495560
Pubmed	Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.	SCN1A SCN2A SCN3A	1.15e-05	12	132	3	8169823
Pubmed	MyD88-dependent signaling contributes to host defense against ehrlichial infection.	TLR7 NLRP3 TLR4	1.15e-05	12	132	3	20668698
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	UBR2 BEST1 DNAJC13 TM9SF4 PSMD1 TTC3 PTK2 ANO8 LRPPRC LRFN2 PTPRE SUPT6H HS2ST1 TTC21B CDK5RAP1 IGSF9B MCF2L FBXO21	1.41e-05	1489	132	18	28611215
Pubmed	Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.	SCN2A SCN3A	1.43e-05	2	132	2	20346423
Pubmed	Heat-resistant action potentials require TTX-resistant sodium channels NaV1.8 and NaV1.9.	SCN11A SCN10A	1.43e-05	2	132	2	29970412
Pubmed	Correlation of Nav1.8 and Nav1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas.	SCN11A SCN10A	1.43e-05	2	132	2	24144460
Pubmed	Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.	SCN1A SCN2A	1.43e-05	2	132	2	10827969
Pubmed	The bacterium, nontypeable Haemophilus influenzae, enhances host antiviral response by inducing Toll-like receptor 7 expression: evidence for negative regulation of host anti-viral response by CYLD.	CYLD TLR7	1.43e-05	2	132	2	17608805
Pubmed	Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.	SCN1A SCN2A	1.43e-05	2	132	2	19694741
Pubmed	Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.	SCN2A SCN3A	1.43e-05	2	132	2	11245985
Pubmed	Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling.	ERBB3 ERBB4	1.43e-05	2	132	2	26745281
Pubmed	Differential expression of two sodium channel subtypes in human brain.	SCN1A SCN2A	1.43e-05	2	132	2	1317301
Pubmed	Genetic variations in Toll-like receptors 4 or 7 were not linked to post-bronchiolitis lung function in adolescence.	TLR7 TLR4	1.43e-05	2	132	2	33053215
Pubmed	Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.	SCN2A SCN3A	1.43e-05	2	132	2	23016767
Pubmed	Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.	SCN2A SCN3A	1.43e-05	2	132	2	27153334
Pubmed	Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.	SCN1A SCN3A	1.43e-05	2	132	2	24990319
Pubmed	Bronchial inflammation and bacterial load in stable COPD is associated with TLR4 overexpression.	NOD1 TLR4	1.43e-05	2	132	2	28536249
Pubmed	TLR4 and TLR7 genetic polymorphism in patients with HIV/HCV-coinfection: prevalence and gender-related features.	TLR7 TLR4	1.43e-05	2	132	2	30684342
Pubmed	Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.	SCN1A SCN2A	1.43e-05	2	132	2	31439038
Pubmed	Role of nucleotide-binding oligomerization domain 1 (NOD1) in pericyte-mediated vascular inflammation.	NOD1 TLR4	1.43e-05	2	132	2	26915562
Pubmed	Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages.	NLRP3 TLR4	1.43e-05	2	132	2	27250627
Pubmed	Sodium Channel Nav1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves.	SCN11A SCN10A	1.43e-05	2	132	2	28450535
Pubmed	The upgraded role of HER3 and HER4 receptors in breast cancer.	ERBB3 ERBB4	1.43e-05	2	132	2	19481955
Pubmed	Infection mobilizes hematopoietic stem cells through cooperative NOD-like receptor and Toll-like receptor signaling.	NOD1 TLR4	1.43e-05	2	132	2	24882704
Pubmed	Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.	SCN1A SCN2A	1.43e-05	2	132	2	15249644
Pubmed	Prognostic significance of serum ERBB3 and ERBB4 mRNA in lung adenocarcinoma patients.	ERBB3 ERBB4	1.43e-05	2	132	2	26254096
Pubmed	Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.	SCN1A SCN3A	1.43e-05	2	132	2	27690330
Pubmed	TLR4 Signaling Selectively and Directly Promotes CGRP Release from Vagal Afferents in the Mouse.	TLR4 SCN10A	1.43e-05	2	132	2	33318075
Pubmed	Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache.	SCN11A SCN10A	1.43e-05	2	132	2	31534133
Pubmed	[Expression and significance of ErbB3 and ErbB4 in patients with laryngeal squamous cell carcinomas].	ERBB3 ERBB4	1.43e-05	2	132	2	17969526
Pubmed	Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.	SCN1A SCN3A	1.43e-05	2	132	2	23965409
Pubmed	Lactoferrin Retargets Human Adenoviruses to TLR4 to Induce an Abortive NLRP3-Associated Pyroptotic Response in Human Phagocytes.	NLRP3 TLR4	1.43e-05	2	132	2	34093588
Pubmed	Toll-like receptor 4-interacting SPA4 peptide suppresses the NLRP3 inflammasome in response to LPS and ATP stimuli.	NLRP3 TLR4	1.43e-05	2	132	2	26254306
Pubmed	SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.	SCN1A SCN2A	1.43e-05	2	132	2	30693367
Pubmed	Ethanol-Induced TLR4/NLRP3 Neuroinflammatory Response in Microglial Cells Promotes Leukocyte Infiltration Across the BBB.	NLRP3 TLR4	1.43e-05	2	132	2	26555554
Pubmed	Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.	SCN1A SCN2A	1.43e-05	2	132	2	29649454
Pubmed	TLR4-dependent upregulation of the platelet NLRP3 inflammasome promotes platelet aggregation in a murine model of hindlimb ischemia.	NLRP3 TLR4	1.43e-05	2	132	2	30522866
Pubmed	Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients.	ERBB3 ERBB4	1.43e-05	2	132	2	18182100
Pubmed	Tetrodotoxin-resistant voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 are expressed in the retina.	SCN11A SCN10A	1.43e-05	2	132	2	18399542
Pubmed	HER3, but Not HER4, Plays an Essential Role in the Clinicopathology and Prognosis of Gastric Cancer: A Meta-Analysis.	ERBB3 ERBB4	1.43e-05	2	132	2	27536774
Pubmed	Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis.	NLRP3 TLR4	1.43e-05	2	132	2	27321991
Pubmed	Activation of NLRP3 inflammasome by lymphocytic microparticles via TLR4 pathway contributes to airway inflammation.	NLRP3 TLR4	1.43e-05	2	132	2	31759058
Pubmed	A Novel TLR4-Binding Domain of Peroxiredoxin From Entamoeba histolytica Triggers NLRP3 Inflammasome Activation in Macrophages.	NLRP3 TLR4	1.43e-05	2	132	2	34659265
Pubmed	Mycoplasma pneumoniae lipids license TLR-4 for activation of NLRP3 inflammasome and autophagy to evoke a proinflammatory response.	NLRP3 TLR4	1.43e-05	2	132	2	32894580
Pubmed	Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.	SCN1A SCN2A	1.43e-05	2	132	2	33096315
Pubmed	HER3 and HER4 are highly expressed in human meningiomas.	ERBB3 ERBB4	1.43e-05	2	132	2	31400925
Pubmed	p38δ MAPK: A Novel Regulator of NLRP3 Inflammasome Activation With Increased Expression in Coronary Atherogenesis.	NLRP3 MAPK13	1.43e-05	2	132	2	27417584
Pubmed	TLR4/7-mediated host-defense responses of gingival epithelial cells.	TLR7 TLR4	1.43e-05	2	132	2	38726711
Pubmed	Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.	SCN1A SCN2A	1.43e-05	2	132	2	26311622
Pubmed	Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis.	LGALS8 TLR4	1.43e-05	2	132	2	36603009
Pubmed	Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout mice.	SCN11A SCN10A	1.43e-05	2	132	2	19931571
Pubmed	Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons.	SCN11A SCN10A	1.43e-05	2	132	2	34930944
Pubmed	Dissecting the role of sodium currents in visceral sensory neurons in a model of chronic hyperexcitability using Nav1.8 and Nav1.9 null mice.	SCN11A SCN10A	1.43e-05	2	132	2	16857712
Pubmed	4-Phenybutyric acid promotes gastric cancer cell migration via histone deacetylase inhibition-mediated HER3/HER4 up-regulation.	ERBB3 ERBB4	1.43e-05	2	132	2	28851073
Pubmed	TMEM16B determines cholecystokinin sensitivity of intestinal vagal afferents of nodose neurons.	ANO2 SCN10A	1.43e-05	2	132	2	30843875
Pubmed	Human metapneumovirus glycoprotein G inhibits TLR4-dependent signaling in monocyte-derived dendritic cells.	TLR7 TLR4	1.43e-05	2	132	2	21632720
Pubmed	The Nav1.9 channel is a key determinant of cold pain sensation and cold allodynia.	SCN11A SCN10A	1.43e-05	2	132	2	25959819
Pubmed	A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses.	NOD1 TLR4	1.43e-05	2	132	2	22870324
Pubmed	The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.	SCN1A SCN2A	1.43e-05	2	132	2	21377452
Pubmed	ErbB family immunohistochemical expression in colorectal cancer patients with higher risk of recurrence after radical surgery.	ERBB3 ERBB4	1.43e-05	2	132	2	19390858
Pubmed	Extracellular nucleoprotein exacerbates influenza virus pathogenesis by activating Toll-like receptor 4 and the NLRP3 inflammasome.	NLRP3 TLR4	1.43e-05	2	132	2	35459853
Pubmed	Hyperin protects against LPS-induced acute kidney injury by inhibiting TLR4 and NLRP3 signaling pathways.	NLRP3 TLR4	1.43e-05	2	132	2	27813491
Pubmed	RNA is an Adjuvanticity Mediator for the Lipid-Based Mucosal Adjuvant, Endocine.	TLR7 NLRP3 TLR4	1.49e-05	13	132	3	27374884
Pubmed	Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity.	TLR7 NLRP3 TLR4	1.49e-05	13	132	3	28504245
Pubmed	Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.	TLR7 NLRP3 TLR4	1.89e-05	14	132	3	19570822
Pubmed	Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients.	TLR7 NOD1 TLR4	1.89e-05	14	132	3	20595247
Interaction	FZD10 interactions	TBC1D9B SETX VPS8 XPO4 GLMN NCAPD2	4.06e-06	66	129	6	int:FZD10
Interaction	SIGLECL1 interactions	TBC1D9B SETX VPS8 ARFGEF2 XPO4 MAP3K4 SNX14	8.22e-06	113	129	7	int:SIGLECL1
Interaction	CBLB interactions	CYLD DTX1 PSMD1 CBL PTK2 NLRP3 TLR4	9.23e-06	115	129	7	int:CBLB
Interaction	C19orf38 interactions	TBC1D9B SETX VPS8 XPO4 CYFIP2 RABGAP1L	1.89e-05	86	129	6	int:C19orf38
Interaction	VIPR2 interactions	VPS18 SETX VPS8 XPO4 CYFIP2 GLMN RABGAP1L NCAPD2	3.60e-05	194	129	8	int:VIPR2
Interaction	SCN10A interactions	SCN11A SCN1A SCN10A	4.07e-05	11	129	3	int:SCN10A
Cytoband	2q24.3	SCN1A SCN2A TTC21B	1.27e-05	16	132	3	2q24.3
Cytoband	3p22.2	SCN11A TRANK1 SCN10A	4.50e-05	24	132	3	3p22.2
Cytoband	Ensembl 112 genes in cytogenetic band chr2q24	SCN1A SCN2A SCN3A TTC21B	5.13e-04	127	132	4	chr2q24
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN11A SCN1A SCN2A SCN3A SCN10A	3.39e-10	9	90	5	1203
GeneFamily	Erb-b2 receptor tyrosine kinases	ERBB3 ERBB4	1.46e-04	4	90	2	1096
GeneFamily	Ubiquitin specific peptidases	CYLD USP44 USP51 USP27X	1.73e-04	56	90	4	366
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	NCF2 TTC3 TRANK1 CTR9 TTC21B	2.73e-04	115	90	5	769
GeneFamily	INO80 complex \|SRCAP complex	RUVBL2 ACTR6	8.62e-04	9	90	2	1329
GeneFamily	CD molecules\|Toll like receptors	TLR7 TLR4	1.07e-03	10	90	2	948
GeneFamily	Anoctamins	ANO2 ANO8	1.07e-03	10	90	2	865
GeneFamily	Dyneins, axonemal	DNAH3 DNAH5	3.17e-03	17	90	2	536
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRE PTPRM	4.84e-03	21	90	2	813
Coexpression	DAIRKEE_CANCER_PRONE_RESPONSE_BPA	ERBB3 FARSB PSMD1 DHX15 ZFYVE26	5.86e-06	51	132	5	M8655
Coexpression	GSE11961_FOLLICULAR_BCELL_VS_MARGINAL_ZONE_BCELL_UP	DTX1 AZGP1 ARFGEF2 NCF2 LGALS8 THBS2 SCN2A DNAH5	8.20e-06	200	132	8	M9381
Coexpression	GSE28726_NAIVE_VS_ACTIVATED_CD4_TCELL_UP	DOCK2 CYLD DLGAP1 CYFIP2 LGALS8 TRANK1 NCAPD2 MCF2L	8.20e-06	200	132	8	M8320
Coexpression	ZENG_GU_ICB_CONTROL_METAGENE_44_PRECICTIVE_ICB_RESPONSE	DOCK2 XRN2 GPR35 FARSB CBL INPP4B NLRP3 ALG6	1.02e-05	206	132	8	MM17084
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP	UBR2 DNAJC13 SETX AGPAT5 ARFGEF2 FASTKD2 TLR7 TTC3 RUVBL2 CYFIP2 HMG20B GLMN IBTK LRPPRC NOD1 ACTR6 RABGAP1L CDK5RAP1 ST6GALNAC4	1.12e-05	1215	132	19	M41122
Coexpression	GSE19941_IL10_KO_VS_IL10_KO_AND_NFKBP50_KO_LPS_AND_IL10_STIM_MACROPHAGE_DN	RNASE9 PSMD1 MSH4 TTC3 CYFIP2 IBTK TLR4	2.10e-05	165	132	7	M8121
Coexpression	GSE37533_PPARG2_FOXP3_VS_FOXP3_TRANSDUCED_CD4_TCELL_DN	CYLD SETX LGALS8 TRANK1 KCTD14 ZFYVE26 ACSL5	6.71e-05	198	132	7	M8969
Coexpression	GSE10273_HIGH_IL7_VS_HIGH_IL7_AND_IRF4_IN_IRF4_8_NULL_PRE_BCELL_UP	PLK2 VPS18 AGPAT5 PSMD1 HEATR5A THBS2 OTUD6B	7.15e-05	200	132	7	M320
Coexpression	GSE6092_UNSTIM_VS_IFNG_STIM_ENDOTHELIAL_CELL_UP	C5orf22 DTX1 VPS8 PLXND1 RMDN2 ANO8 GLMN	7.15e-05	200	132	7	M6710
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ERBB3 ERBB4 AZGP1 CSMD3 SCN1A SCN2A PLAT IGSF9B	1.30e-07	196	132	8	f374cb3ec31c6eef2cef9e07547bfd1e380553af
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ERBB3 ERBB4 AZGP1 CSMD3 SCN1A SCN2A PLAT IGSF9B	1.30e-07	196	132	8	671c380b58d7f634b4fbec38c357d357ea4f3535
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ARFGEF2 APLP2 NCF2 COLGALT1 PTPRE ZBED6 TLR4	2.20e-06	199	132	7	379bbd9cecf466b902411c54d74bd9885285b1ba
ToppCell	Macroglial-Polydendrocytes-PDGFRA-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DLGAP1 CSMD3 PTPRE SCN1A SCN2A SCN3A HS6ST3	2.28e-06	200	132	7	f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCell	Macroglial-Polydendrocytes-PDGFRA--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DLGAP1 CSMD3 PTPRE SCN1A SCN2A SCN3A HS6ST3	2.28e-06	200	132	7	cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCell	Macroglial-Polydendrocytes-PDGFRA\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DLGAP1 CSMD3 PTPRE SCN1A SCN2A SCN3A HS6ST3	2.28e-06	200	132	7	c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCell	Macroglial-Polydendrocytes-PDGFRA---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DLGAP1 CSMD3 PTPRE SCN1A SCN2A SCN3A HS6ST3	2.28e-06	200	132	7	4fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCell	Macroglial-Polydendrocytes-PDGFRA----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DLGAP1 CSMD3 PTPRE SCN1A SCN2A SCN3A HS6ST3	2.28e-06	200	132	7	310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCell	Macroglial-Polydendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DLGAP1 CSMD3 PTPRE SCN1A SCN2A SCN3A HS6ST3	2.28e-06	200	132	7	961858738ce35db8760c8c2e136f8369bc444ccf
ToppCell	facs-Lung-Endomucin-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR35 NCF2 TLR7 CYFIP2 ZFYVE9 PTPRE	7.48e-06	157	132	6	0ad242320ada7bcb9e29548d3050bf4fd3a07115
ToppCell	facs-Lung-Endomucin-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR35 NCF2 TLR7 CYFIP2 ZFYVE9 PTPRE	7.48e-06	157	132	6	fe4c9556806203e57522d1986754ebe5a20aa2de
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Hsd11b1_Endou\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	IL12A COL5A2 CCDC80 PLXND1 HS6ST3 DNAH5	7.75e-06	158	132	6	c8af8964a140acb2987e3b4906d72c546108d229
ToppCell	droplet-Liver-LIVER-NPC-1m-Lymphocytic-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 DTX1 ANO8 GLMN SSH3 KCTD14	9.93e-06	165	132	6	8c7a6f9e2ca0ce077426d3d0726e3f5a4c03b296
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ERBB3 PLK2 ERBB4 TLR7 CIT PTPRE	1.18e-05	170	132	6	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ERBB3 ERBB4 AZGP1 CYFIP2 IGSF9B HS6ST3	1.48e-05	177	132	6	59726bfd98f656fdcedf448a7e2e76a9bfad8285
ToppCell	Hippocampus-Neuronal-Inhibitory\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ERBB4 NEB CIT ANKRD34B PTPRM SCN1A	1.73e-05	182	132	6	b54ae650c04dfd0759c5f5e752b9bf684dd36516
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 NEB CSMD3 TRANK1 SCN2A DNAH5	1.84e-05	184	132	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 NEB CSMD3 TRANK1 SCN2A DNAH5	1.84e-05	184	132	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 NEB CSMD3 TRANK1 SCN2A DNAH5	1.84e-05	184	132	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MUC19 CSMD3 PTPRE SCN2A SCN10A KDM7A	1.96e-05	186	132	6	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	HEATR5A LRPPRC LATS1 ZBED6 CTR9 POLR1B	2.41e-05	193	132	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK2 COL5A2 PLK2 CSMD3 THBS2 PLAT	2.41e-05	193	132	6	cd45118ced91b10baed3b1068d4673ec99824b86
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	BEST1 APLP2 NCF2 NLRP3 PTPRE TLR4	2.41e-05	193	132	6	69352551ad5db325ac0d6df2ac1e35ae473ac01f
ToppCell	COPD-Endothelial-VE_Capillary_B\|World / Disease state, Lineage and Cell class	ANO2 ZCWPW2 PTPRM APLNR PLAT MCF2L	2.48e-05	194	132	6	68705a6eca947c5b42b943d5224a7aef2a744007
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ANO2 PLK2 PLXND1 APLNR PLAT MCF2L	2.48e-05	194	132	6	fc2e0081005c0c496e41197a2d06e4a37708221f
ToppCell	COPD-Endothelial-VE_Capillary_B\|COPD / Disease state, Lineage and Cell class	ANO2 ZCWPW2 PTPRM APLNR PLAT MCF2L	2.48e-05	194	132	6	18b7f901c12ca4f21f9a1eafd092aefe4d668b6d
ToppCell	COVID-19-kidney-PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	ANO2 PLK2 PLXND1 PTPRE PLAT MCF2L	2.55e-05	195	132	6	a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK2 NCF2 TLR7 NLRP3 PTPRE TLR4	2.55e-05	195	132	6	c14d730dd5c94247bc09711eaa5a53bd5a5957be
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	BEST1 APLP2 NCF2 NLRP3 PTPRE TLR4	2.63e-05	196	132	6	1d170422a9eb5e477ce837f9da1c7db95ee5da1c
ToppCell	COVID-19-kidney-VWF+PLVAP+VCAM1+EC\|kidney / Disease (COVID-19 only), tissue and cell type	ANO2 PLK2 PLXND1 PTPRE PTPRM PLAT	2.63e-05	196	132	6	ac2c4a325efa8497a755cd31fb6a9d94d8e3bf42
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Monocytic\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	BEST1 APLP2 NCF2 NLRP3 PTPRE TLR4	2.63e-05	196	132	6	efddf04f32fc01ab2c1dfb5a7ab0931f0fe86eff
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANO2 PLXND1 PTPRE PTPRM APLNR PLAT	2.63e-05	196	132	6	ab7be3858deabbd1fc44e8b9da8ff49a50bf1fb1
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	BEST1 APLP2 NCF2 NLRP3 PTPRE TLR4	2.63e-05	196	132	6	782aa9e75ad032627d95dba763a37ae2b1f7f503
ToppCell	PBMC-Control-cDC_3\|Control / Compartment, Disease Groups and Clusters	CYLD ARFGEF2 CYFIP2 DHX15 ZBED6 ACSL5	2.63e-05	196	132	6	09d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Monocytic-Classical_Monocyte\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	BEST1 APLP2 NCF2 NLRP3 PTPRE TLR4	2.70e-05	197	132	6	ad589eaf49921e128d5eb38173e4b0c4515abeec
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GPR35 APLP2 NCF2 NLRP3 PTPRE TLR4	2.70e-05	197	132	6	a1d42d0177630e08f36a96a6272f796244c1a319
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLK2 APLP2 PTPRE PLAT FBXO21 DNAH5	2.70e-05	197	132	6	d9e196c8b4a6ede4733946dbdba3331534954beb
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GPR35 APLP2 NCF2 NLRP3 PTPRE TLR4	2.70e-05	197	132	6	bb0d814d88a14199eb8ab2b3bd67511b19e3ab5d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	BEST1 APLP2 NCF2 NLRP3 PTPRE TLR4	2.70e-05	197	132	6	59745f84346efdcb2ab864a84681f043ba4c9b86
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP1 TTC3 CSMD3 SCN1A SCN2A SCN3A	2.78e-05	198	132	6	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	cellseq2-Immune-Immune_Myeloid-iMON-iMON\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DOCK2 NCF2 NLRP3 ANKRD34B PTPRE TLR4	2.78e-05	198	132	6	a6aa113f0af4d25c032f440c3134fe4d88ca5055
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP1 TTC3 CSMD3 SCN1A SCN2A SCN3A	2.78e-05	198	132	6	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	cellseq2-Immune-Immune_Myeloid-iMON\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DOCK2 NCF2 NLRP3 ANKRD34B PTPRE TLR4	2.78e-05	198	132	6	a0ceed8689d42be6b9cde89d6c182d10b3fb14fc
ToppCell	5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANO2 PLXND1 PTPRM APLNR PLAT MCF2L	2.86e-05	199	132	6	07bda4ac8ffdce1a865ebc99e46c2a27925ff7a8
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intermediate\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 BEST1 NCF2 PLXND1 NLRP3 PTPRE	2.86e-05	199	132	6	54167894a16e975d0541cbe3e515bcfa183044f6
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLK2 APLP2 PTPRE PLAT STARD3NL DNAH5	2.86e-05	199	132	6	05777e92344aedabfb5a72207c6632dc64205534
ToppCell	wk_08-11-Hematologic-Myeloid-SPP1+_Mac\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	DOCK2 NCF2 TLR7 NLRP3 PTPRE TLR4	2.86e-05	199	132	6	d94cf750599366061066074e8007d707adf6fc5a
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_other\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 NCF2 TLR7 PLXND1 NLRP3 PTPRE	2.94e-05	200	132	6	f3dc07a7cc8cf041da8fe610d21af595818cf2d8
ToppCell	wk_08-11-Hematologic-Myeloid\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	DOCK2 NCF2 TLR7 NLRP3 PTPRE TLR4	2.94e-05	200	132	6	148e09e27e4a563bdd1fbe9a593cd938885cbb1b
ToppCell	PND07-28-samps-Lymphocyte-B_cell-B_cell_2\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	IL12A DTX1 CYFIP2 RABGAP1L PRSS42P	5.52e-05	137	132	5	2544d1256f11da6e3bad24a871b2253e0ab20d01
ToppCell	PND07-28-samps-Lymphocyte-B_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	IL12A DTX1 CYFIP2 RABGAP1L PRSS42P	5.52e-05	137	132	5	874e2eaa7846a2832f46b77c726d79f220a4a1cd
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ERBB3 ERBB4 USP44 NOD1 DNAH5	7.96e-05	148	132	5	9fe3c0a5904b8e9a0f28130f8d84d4f2a819b06c
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ANO2 CSMD3 SHISAL1 SCN1A DNAH5	8.21e-05	149	132	5	c5eedb54ef2e0f131aa6730612c921bc19479632
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ANO2 CSMD3 SHISAL1 SCN1A DNAH5	8.21e-05	149	132	5	a22417286de8606f0cc94f86b70bce17aeefb9c2
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ERBB3 SCN1A SCN2A SCN3A IGSF9B	9.89e-05	155	132	5	77fdae85d36efb776db977eb424b32487ef222e4
ToppCell	356C-Lymphocytic-ILC-ILC-2\|356C / Donor, Lineage, Cell class and subclass (all cells)	GPR35 DTX1 XPO4 INPP4B POLR1B	9.89e-05	155	132	5	0fd66c623cb433ceaa893bc21ba2e3b394faaf70
ToppCell	PND07-28-samps-Myeloid-Granulocyte-neutrophil__Lgals3-negative\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	DOCK2 GPR35 CBL CYFIP2 PTPRE	1.02e-04	156	132	5	166f7b1220eaf8e1149dde260dd85a094855c54f
ToppCell	PND07-28-samps-Myeloid-Granulocyte\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	DOCK2 GPR35 CBL CYFIP2 PTPRE	1.02e-04	156	132	5	5e1c5a7c9293b886920739cf766521df7f69726c
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR35 NCF2 TLR7 CYFIP2 PTPRE	1.12e-04	159	132	5	cdbccb83af6220bab300dfe56443ff69f6e2043a
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCF2 TLR7 CYFIP2 ZFYVE9 PTPRE	1.15e-04	160	132	5	2020b6defbaf5b5db12af37f0103ac028a8ca76e
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCF2 TLR7 CYFIP2 ZFYVE9 PTPRE	1.15e-04	160	132	5	af7cf0dc5fe7c02f7d6c436f6dde766c79ff0eae
ToppCell	PND07-Endothelial-Endothelial_lymphatic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN11A DTX1 APLP2 SCN1A SCN3A	1.18e-04	161	132	5	133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NCF2 TLR7 NLRP3 BEND6 ZFYVE26	1.18e-04	161	132	5	5a8698790f9aba796dd2b64af419055c60bd7de8
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN11A DTX1 APLP2 SCN1A SCN3A	1.18e-04	161	132	5	9466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN11A DTX1 APLP2 SCN1A SCN3A	1.18e-04	161	132	5	cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ERBB4 ANKUB1 NEB CSMD3 SCN10A	1.22e-04	162	132	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN11A DTX1 APLP2 SCN1A SCN3A	1.22e-04	162	132	5	96c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCell	TCGA-Head_and_Esophagus-Solid_Tissue_Normal-Head_and_Neck-Head_and_Neck_normal_tissue-2\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	ERBB4 ZCWPW2 AZGP1 MUC19 METTL21EP	1.25e-04	163	132	5	2dfd11f5803822ba01b92adf4395a3b3adda68f5
ToppCell	facs-Lung-3m-Hematologic-myeloid-non-classical_monocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK2 NCF2 TLR7 CYFIP2 PTPRE	1.25e-04	163	132	5	bbbc3f0ce2616d07136f69ce682ba1d3790711d9
ToppCell	droplet-Lung-3m-Hematologic-myeloid-non-classical_monocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPR35 NCF2 TLR7 CYFIP2 PTPRE	1.25e-04	163	132	5	f6c8db5963ee1f8e0c2996f1aeecd58c00e9b099
ToppCell	facs-Lung-EPCAM-24m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 NCF2 TLR7 CYFIP2 PTPRE	1.29e-04	164	132	5	15d52666e5150e7c34b1f641a937fb2d5e8aaf8a
ToppCell	facs-Lung-EPCAM-24m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 NCF2 TLR7 CYFIP2 PTPRE	1.29e-04	164	132	5	d622f0d8d8bad48dfdf160ec63c545df192637a9
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CIT ANO8 SCN1A CDK5RAP1 DNAH5	1.29e-04	164	132	5	4307b002fb41ddfc7ab8a6bca66a60942c250052
ToppCell	droplet-Lung-3m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPR35 NCF2 TLR7 CYFIP2 PTPRE	1.29e-04	164	132	5	ea2897942ad72fba900c7ab354d6a9e203bf0e4a
ToppCell	facs-MAT-Fat-3m-Myeloid-macrophage\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 GPR35 NCF2 PLXND1 PTPRE	1.29e-04	164	132	5	b81498c3934e0d52bf0329dc745e02966f9d8613
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CIT ANO8 SCN1A CDK5RAP1 DNAH5	1.29e-04	164	132	5	1d84aa5b925f502ee9c5fa39714490f613a58028
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DTX1 CUBN SHISAL1 PTPRE IGSF9B	1.29e-04	164	132	5	0853e75b60b2a78257b660910c3ee15b09c5f5b0
ToppCell	droplet-Lung-nan-18m-Myeloid-intermediate_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR35 NCF2 TLR7 PTPRE KDM7A	1.33e-04	165	132	5	e32697321cef424c2ad4e11ee9da3e510d5ce505
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHISAL1 LRFN2 IGSF9B DNAH5 ALG6	1.33e-04	165	132	5	1703d3eb644b3c743ad3c5532b1d29ea010c79c8
ToppCell	droplet-Lung-nan-18m-Myeloid-Intermediate_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR35 NCF2 TLR7 PTPRE KDM7A	1.33e-04	165	132	5	0fbdd043e11aa8dbff4cd3a4da1b2feb49878a09
ToppCell	droplet-Fat-SCAT-30m-Lymphocytic-B_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DTX1 XPO4 CUBN ZFYVE9 RABGAP1L	1.36e-04	166	132	5	4b31d2755108b2815316411a38bfb11fd30ef98a
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ERBB3 ERBB4 PTK2 NOD1 DNAH5	1.36e-04	166	132	5	c20479fe7a4306320d7f26e78bf956225f00f35a
ToppCell	facs-Kidney-nan-3m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCF2 TLR7 NLRP3 PTPRE TLR4	1.40e-04	167	132	5	991a93e1075d562b7391f0689b2f62c1351d48d1
ToppCell	facs-Kidney-nan-3m-Myeloid\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCF2 TLR7 NLRP3 PTPRE TLR4	1.40e-04	167	132	5	f22d1471c785b30d096ec5cdc68974e850ed7de0
ToppCell	facs-Kidney-nan-3m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCF2 TLR7 NLRP3 PTPRE TLR4	1.40e-04	167	132	5	934905aeaafbc215ec8f6a7903498b0e258b9220
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_proliferating_SCP3_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ERBB3 ERBB4 SCN1A IGSF9B HS6ST3	1.40e-04	167	132	5	49b19159c62d33d65ed1e59a148c11ae902fd41c
ToppCell	facs-Lung-24m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK2 NCF2 TLR7 CYFIP2 PTPRE	1.44e-04	168	132	5	c0aef5947b1d7e2c81a7481c509feda1687fcd7f
ToppCell	droplet-Kidney-KIDNEY-1m-Myeloid\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCF2 TLR7 NLRP3 PTPRE TLR4	1.44e-04	168	132	5	94282484033be80b6c0978090c06c0d8fcf17e9e
ToppCell	droplet-Kidney-KIDNEY-1m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCF2 TLR7 NLRP3 PTPRE TLR4	1.44e-04	168	132	5	7d4ddcc03a16ecdc23f961b94e864e6cf110820d
ToppCell	facs-Lung-24m-Hematologic-myeloid-non-classical_monocyte\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK2 NCF2 TLR7 CYFIP2 PTPRE	1.44e-04	168	132	5	c861f80aa12caf54a94d93e38539ff41dc5227a6
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CUBN CSMD3 TRANK1 SCN3A DNAH5	1.48e-04	169	132	5	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 CCNB3 TTLL2 GNAT3 DNAH5	1.52e-04	170	132	5	17bd7fd25a2657cb536ad47e294332920f759e95
ToppCell	356C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GPR35 DTX1 XPO4 NOD1 POLR1B	1.57e-04	171	132	5	3d26ef58fe5231373d7df9ac79d225546918cf82
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANO2 SCN11A PLXND1 APLNR MCF2L	1.57e-04	171	132	5	b3e6e31dfe3623b960ccf692fdbd236fa4039923
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Granulocytic-Neutrophil\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	BEST1 NCF2 NLRP3 ANKRD34B TLR4	1.61e-04	172	132	5	c32e6af9e2d29da47b5d870207b598cff11aef6c
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	BEST1 NCF2 NLRP3 ANKRD34B TLR4	1.61e-04	172	132	5	0b247fe57163af08132db8df42e6757699885295
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Granulocytic\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	BEST1 NCF2 NLRP3 ANKRD34B TLR4	1.61e-04	172	132	5	1a0556c97fcba126126c22adea5235d977d41ebe
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANO2 DLGAP1 SCN11A ZCWPW2 APLNR	1.70e-04	174	132	5	6b5ff1cc5fe6705f7ea70b5a892dfbf91e32288d
ToppCell	facs-Trachea-3m-Hematologic-myeloid\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK2 GPR35 NCF2 TLR7 NLRP3	1.75e-04	175	132	5	22fd7d9b4d403cc8061316855f78bad0eb705ce9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Plasmacytoid_Dendritic_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 COLGALT1 LRFN2 PTPRE ZFYVE26	1.79e-04	176	132	5	8488997e0f02e874f53fae1690da63e0dd1d0780
Drug	Zonisamide	SCN11A SCN1A SCN2A SCN3A	2.42e-06	17	132	4	DB00909
Drug	APETx1, Anthopleura elegantissima	SCN2A SCN3A SCN10A	3.76e-06	6	132	3	ctd:C475726
Drug	fenpropathrin	SCN2A SCN3A SCN10A	3.76e-06	6	132	3	ctd:C044267
Drug	2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate	SCN2A SCN3A SCN10A	1.04e-05	8	132	3	ctd:C489827
Drug	Fluticasone propionate [80474-14-2]; Down 200; 8uM; HL60; HT_HG-U133A	CYLD DNAH3 TM9SF4 ZFYVE9 SSH3 RABGAP1L KDM7A FBXO21	1.49e-05	189	132	8	2928_DN
Drug	morin hydrate	IL12A SETX RUVBL2 LRPPRC NCAPD2	2.00e-05	57	132	5	CID003365422
Drug	Tolmetin sodium salt dihydrate [64490-92-2]; Down 200; 12.6uM; HL60; HT_HG-U133A	ANO2 ERBB3 GPR35 NEB CYFIP2 NOD1 ZFYVE9 SSH3	2.01e-05	197	132	8	3009_DN
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN11A SCN1A SCN2A SCN3A SCN10A	4.11e-10	10	132	5	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN11A SCN1A SCN2A SCN3A SCN10A	4.11e-10	10	132	5	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN11A SCN1A SCN2A SCN3A SCN10A	1.28e-09	12	132	5	DOID:0060170 (implicated_via_orthology)
Disease	Primary Erythermalgia	SCN11A SCN10A	5.94e-05	3	132	2	C0014805
Disease	PAROXYSMAL EXTREME PAIN DISORDER	SCN11A SCN10A	5.94e-05	3	132	2	C1833661
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	ERBB3 ERBB4 ANKUB1 PTK2 INPP4B LRPPRC LRFN2 SCN2A TLR4 IGSF9B MAPK13 HS6ST3 TMEM18	6.54e-05	801	132	13	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	cognitive function measurement	PLK2 ERBB4 VPS8 XPO4 CSMD3 PTK2 DHX15 GLMN LRPPRC THBS2 LRFN2 TTLL2 RABGAP1L SCN2A TTC21B IGSF9B DNAH5 ACSL5	7.30e-05	1434	132	18	EFO_0008354
Disease	epilepsy (implicated_via_orthology)	SCN11A CIT SCN1A SCN2A SCN3A SCN10A	9.56e-05	163	132	6	DOID:1826 (implicated_via_orthology)
Disease	muscle measurement	PLK2 NEB	1.18e-04	4	132	2	EFO_0004515
Disease	anxiety disorder (implicated_via_orthology)	SCN1A SCN2A SCN3A	1.27e-04	22	132	3	DOID:2030 (implicated_via_orthology)
Disease	stomach carcinoma (is_marker_for)	ERBB3 ERBB4 AZGP1	1.65e-04	24	132	3	DOID:5517 (is_marker_for)
Disease	social communication impairment	SCN11A TTC21B SCN10A	3.95e-04	32	132	3	EFO_0005427
Disease	Seizure, Febrile, Simple	SCN1A SCN2A	4.11e-04	7	132	2	C0149886
Disease	Seizure, Febrile, Complex	SCN1A SCN2A	4.11e-04	7	132	2	C0751057
Disease	Congenital Pain Insensitivity	SCN11A SCN10A	4.11e-04	7	132	2	C0002768
Disease	Hereditary Sensory Autonomic Neuropathy, Type 5	SCN11A SCN10A	4.11e-04	7	132	2	C0020075
Disease	visual epilepsy (implicated_via_orthology)	ERBB4 NCF2 CIT	4.73e-04	34	132	3	DOID:11832 (implicated_via_orthology)
Disease	Febrile Convulsions	SCN1A SCN2A	7.00e-04	9	132	2	C0009952
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN1A SCN2A	7.00e-04	9	132	2	C3502809
Disease	glioblastoma (implicated_via_orthology)	USP51 USP27X	7.00e-04	9	132	2	DOID:3068 (implicated_via_orthology)
Disease	ductal carcinoma in situ (is_marker_for)	ERBB3 ERBB4 PTK2	7.11e-04	39	132	3	DOID:0060074 (is_marker_for)
Disease	Head and Neck Carcinoma	CYLD ERBB3	8.73e-04	10	132	2	C3887461
Disease	C-reactive protein measurement	UBR2 ERBB4 CBL CIT NLRP3 CYFIP2 USP44 GLMN LATS1 TRANK1 LRFN2 APLNR POLR1B TMEM18	1.04e-03	1206	132	14	EFO_0004458
Disease	gallbladder neoplasm	ERBB3 ERBB4	1.06e-03	11	132	2	C0016978
Disease	Malignant neoplasm of gallbladder	ERBB3 ERBB4	1.06e-03	11	132	2	C0153452
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN2A	1.50e-03	13	132	2	C0751122
Disease	median neuropathy (biomarker_via_orthology)	ERBB3 ERBB4	1.74e-03	14	132	2	DOID:571 (biomarker_via_orthology)
Disease	Adenocarcinoma Of Esophagus	DOCK2 TLR4	1.74e-03	14	132	2	C0279628
Disease	MMR-related febrile seizures	SCN1A SCN2A	2.01e-03	15	132	2	EFO_0006519
Disease	Early infantile epileptic encephalopathy with suppression bursts	SCN1A SCN2A	2.29e-03	16	132	2	C0393706
Disease	renal fibrosis (implicated_via_orthology)	NCF2 TLR4	2.58e-03	17	132	2	DOID:0050855 (implicated_via_orthology)
Disease	acute kidney failure (is_marker_for)	AZGP1 PLAT	2.58e-03	17	132	2	DOID:3021 (is_marker_for)
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR7 TLR4	2.58e-03	17	132	2	DOID:8677 (biomarker_via_orthology)
Disease	Febrile seizure (within the age range of 3 months to 6 years)	SCN1A SCN2A	2.90e-03	18	132	2	HP_0002373
Disease	carcinoma (implicated_via_orthology)	ERBB3 ERBB4 LATS1	2.99e-03	64	132	3	DOID:305 (implicated_via_orthology)
Disease	neck circumference	INPP4B USP44	3.23e-03	19	132	2	EFO_0011043
Disease	laryngeal squamous cell carcinoma (is_marker_for)	ERBB3 ERBB4	3.23e-03	19	132	2	DOID:2876 (is_marker_for)
Disease	osteoarthritis	SCN11A VPS8 CSMD3 RABGAP1L MCF2L	3.29e-03	222	132	5	MONDO_0005178
Disease	aggressive behaviour measurement, ADHD symptom measurement	TLR4 KDM7A HS6ST3	3.55e-03	68	132	3	EFO_0007826, EFO_0007860
Disease	alcohol consumption measurement	COPE FARSB DDX55 CSMD3 CIT INPP4B DHX15 LRPPRC RABGAP1L IGSF9B HS6ST3 DNAH5 TMEM18	3.84e-03	1242	132	13	EFO_0007878

Protein segments in the cluster

Peptide	Gene	Start	Entry
MDSQELKTLINYYCQ	TTC21B	1	Q7Z4L5
KEDVCYVSQDFYRDM	ACTR6	206	Q9GZN1
YQTLYKLYERCEVVM	ERBB3	46	P21860
KYYENCEVVMGNLEI	ERBB4	51	Q15303
LIFTDFQMEEKYDYL	CSMD3	281	Q7Z407
IKESFCYVAMNYEEE	ACTRT3	211	Q9BYD9
LAFCLAINYKQMELY	ALG6	191	Q9Y672
EVMYAYVDQLDFCEK	ARFGEF2	706	Q9Y6D5
EKLQDAYYIFQEMAD	COPE	196	O14579
LMAQKFYQFRELCEE	DLGAP1	841	O14490
MFEKLTLYCDSYIQL	BEST1	61	O76090
MYLYNIQEKDTFFDN	ANO2	261	Q9NQ90
CFRLYTEKAYKTEMQ	DHX15	481	O43143
FYEIDMKQYTLEEFL	CIT	1751	O14578
KFINDLMQVLYTNEY	BEND6	191	Q5SZJ8
NMYVQQRDEYLESFC	CCDC80	636	Q76M96
YQCQIKEDAVEQFMF	CCDC83	31	Q8IWF9
CEMTLQEYHYVQEKA	CCNB3	1286	Q8WWL7
SCMKKYEDTFQDYQE	ANO8	736	Q9HCE9
GDLENTTKVQCYMDY	APLNR	171	P35414
FETKEEVLQYCQEMY	APLP2	81	Q06481
KMSYDEINCQSYLSE	ANKRD34B	316	A5PLL1
MAYYGKCIETVIEQL	CFAP99	1	D6REC4
VLDAMNYVLYDQLKF	FBXO21	261	O94952
HMVQTLEQYEFCYKV	PTPRE	671	P23469
SILYEECISQMYFFI	OR1J2	91	Q8NGS2
VQKYCLMGVQDSYTD	KDM7A	266	Q6ZMT4
MASCSEYFYNILKKD	KLHL31	91	Q9H511
YSEQECMEFKAVIYS	GNAT3	61	A8MTJ3
CEVLYNIAFMYAKKE	NCF2	121	P19878
YFEMIIYCDVREFKV	LGALS8	266	O00214
SFQDKDNLYFVMDYI	LATS1	771	O95835
DMFEYLLQFIYTDTC	IBTK	626	Q9P2D0
QENFELLQEYYKIFM	INPP4B	771	O15327
RLENYYMVCKADEKF	DDX55	241	Q8NHQ9
NEFNTNVAMAEIYKY	PLXND1	1866	Q9Y4D7
SNDYKMICIDEYCQT	MUC19	666	Q7Z5P9
CYAQKEELLLEEIYM	NOD1	146	Q9Y239
EFSEEKIQYLVYQML	MAPK13	121	O15264
ECDRDQMYYNLLKLY	LRPPRC	951	P42704
VLCYFLETNAKQYNM	METTL21EP	101	A6NDL7
ALCLSSIYEDLKMYQ	IL12A	121	P29459
IVNICVDYYENKMYL	CYFIP2	241	Q96F07
LDAICYYYMAKEFQE	GPR35	271	Q9HC97
YDMDICITIQNAYEK	DTX1	121	Q86Y01
NFLDMQLYEYAKDLF	HS6ST3	401	Q8IZP7
EEQAFCVLVKIMYDY	RABGAP1L	636	Q5R372
MYTPEEFQKYCEDIV	OTUD6B	206	Q8N6M0
EMDIEEIQNCYYDKL	CUBN	1896	O60494
YIYSLASCIMEKLQE	HEATR5A	1891	Q86XA9
CKELAEQYEMEIFDY	DOCK2	1301	Q92608
MVVLVQEKENDYYCS	DNAH3	276	Q8TD57
QEKENDYYCSLMKSI	DNAH3	281	Q8TD57
EEEIFYMNCRAAYLT	EFCAB7	31	A8K855
MFTQEEYKILQELYQ	C5orf22	266	Q49AR2
DQMTCLDTLAAYYVQ	CTR9	81	Q6PD62
CNYVKLEDVADMNYF	ACSL5	471	Q9ULC5
ITYICKNSVGYMDDQ	COL5A2	1401	P05997
MVCYLENYEPEKFSE	DNAJC13	1176	O75165
ERMEDFQIYEKYCQN	MCF2L	716	O15068
IKVTQEQYELYCEMG	CBL	361	P22681
EQYELYCEMGSTFQL	CBL	366	P22681
GQKVQDCYFYQIFME	CYLD	706	Q9NQC7
DCYFYQIFMEKNEKV	CYLD	711	Q9NQC7
AEVQMYVCNKEEYGF	COLGALT1	276	Q8NBJ5
YRFCIQNLEYKMEVL	DNAH5	2436	Q8TE73
MVDLLDQYKFCYEVA	PTPRM	1431	P28827
AYQQSEAYKMCTEKI	HMG20B	136	Q9P0W2
KQYYQFMLQEVLEDL	MAP3K4	666	Q9Y6R4
SQLELFYCLYEMQEE	NLRP3	626	Q96P20
YSKEQIQMDDYGLCQ	GLMN	161	Q92990
QYMKEYQDAFLFNEL	RUVBL2	441	Q9Y230
RDAYKTYNITENMLC	PRSS58	166	Q8IYP2
FFYQQVKSDYMLEIA	PTK2	146	Q05397
ENLLDAVYSFCLMNY	FASTKD2	496	Q9NYY8
AMDQAKYNLINEYFL	HS2ST1	236	Q7LGA3
NLLMAYQICFDLYES	PSMD1	241	Q99460
LDDMVTCSQIVYNYN	SETX	346	Q7Z333
DLLYYSAMNYDICKV	SHISAL1	116	Q3SXP7
YMYLAKCYTDLEENQ	RMDN2	361	Q96LZ7
LMEVQSKYYCLAAVA	MSH4	266	O15457
EKAEFYQICEFMYER	VPS8	901	Q8N3P4
EKYVIDENDYMSFIN	SCN3A	1081	Q9NY46
QDIFMTEEQKKYYNA	SCN3A	1481	Q9NY46
LMQYDELQKICYNRF	RNASE9	106	P60153
YNEVNQTYYVLDVMC	SNUPN	176	O95149
CLYVYNKIDQISMEE	DRG2	241	P55039
YYSEVLCFLQDKKMF	KCTD14	181	Q9BQ13
YETAKMLCEQYYLVA	PDK3	201	Q15120
EYTACELMNIYKTDN	FARSB	191	Q9NSD9
QDIFMTEEQKKYYNA	SCN1A	1496	P35498
AYAMKQYECSLEQAL	SSH3	426	Q8TE77
QFIELCKTLYNMFSE	TBC1D9B	1026	Q66K14
EMYDCNTLKDYQTDI	ANKUB1	136	A6NFN9
KQEMLVQYLQDAYSF	NCAPD2	616	Q15021
YTVMAKNCYKDFLEI	C10orf82	126	Q8WW14
KVYLETYGCQMNVND	CDK5RAP1	101	Q96SZ6
LFEKMQAYQYEQISA	SUPT6H	416	Q7KZ85
FMCKDYVYDKDIEQI	USP51	286	Q70EK9
YFEKGRLDECQMYLA	ST6GALNAC4	251	Q9H4F1
MCKDYVYDKDIEQIA	USP27X	1	A6NNY8
SYQVICRDEKTQMIY	PLAT	36	P00750
QICYLGESKAMNLYE	XPO4	866	Q9C0E2
ISIVMVYFQLCAEDY	TM9SF4	551	Q92544
NTLEMYTDYYLQCKL	SNX14	821	Q9Y5W7
DEYSAEMKQFACTLY	THAP9	206	Q9H5L6
YECKVLMLDQQYDTF	IGSF9B	111	Q9UPX0
QDIFMTEEQKKYYNA	SCN10A	1431	Q9Y5Y9
ENTLEKEVMQYDYYS	STARD3NL	81	O95772
KDMHYYQSCLEAILQ	RRAGA	101	Q7L523
FEKMLYDQAQLAVAY	SPATA20	331	Q8TB22
TYLDMNRFDLAKEYC	VPS18	401	Q9P253
FMDNLAKCLRYYIAD	XRN2	166	Q9H0D6
QDIFMTEEQKKYYNA	SCN2A	1486	Q99250
YRINHNEFQCMKEYL	TTC41P	546	Q6P2S7
EFMSNDYVRVTQLYC	TTC3	31	P53804
SEILQDVDQYIMCYE	PRSS42P	216	Q7Z5A4
FIFDDMYIVQKYISN	TTLL2	231	Q9BWV7
YLYNNMIAKIQEDDF	TLR7	231	Q9NYK1
IFMETLKDIVEYYND	AZGP1	96	P25311
YKQFLAEEVCNYMES	ZBED6	791	P86452
QDIFMTEEQKKYYNA	SCN11A	1321	Q9UI33
CYEMTDLTNNKVYAA	PLK2	96	Q9NYY3
LDVKIEYCNYAMDSS	ZCWPW2	6	Q504Y3
SQEMVYFSDLKYECR	THBS2	1156	P35442
FEQIQEFDLALKMYC	TRANK1	1816	O15050
DCMKNYLDAIYDVTV	AGPAT5	216	Q9NUQ2
SFVMYYKSKENCVVD	POLR1B	836	Q9H9Y6
VEKSDTYYCMLFNDE	UBR2	221	Q8IWV8
ITYQCMELNFYKIPD	TLR4	36	O00206
EGKIMNNTYYQECLF	ZFYVE26	2151	Q68DK2
ILVYCAEYINEAAAM	TMEM18	61	Q96B42
TMDEVCKAQAYILFY	USP44	661	Q9H0E7
MENYFQAEAYNLDKV	ZFYVE9	1	O95405
VYMSASEIENCYDLL	JKAMP	231	Q9P055
MYQLQYNCSDDEVLI	LRFN2	451	Q9ULH4
KYQEDFENMKDQIYF	NEB	311	P20929