Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionSUMO ligase activity

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

3.40e-1020946GO:0061665
GeneOntologyMolecularFunctionSUMO transferase activity

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.61e-0836946GO:0019789
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.25e-0750946GO:0003755
GeneOntologyMolecularFunctioncis-trans isomerase activity

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.78e-0753946GO:0016859
GeneOntologyMolecularFunctionisomerase activity

RGPD4 RGPD2 RANBP2 GNPDA1 RGPD8 RGPD3 RGPD1 PUS7L

3.47e-06192948GO:0016853
GeneOntologyMolecularFunctionGTPase activator activity

RGPD4 RGPD2 RANBP2 RGPD8 STXBP5 RGPD3 RGPD1 RGPD5

5.18e-05279948GO:0005096
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 MED31 RGPD1 ZNF598 MED12

1.08e-04398949GO:0061659
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 MED31 RGPD1 ZNF598 MED12 CDC23

1.48e-045129410GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 MED31 RGPD1 ZNF598 MED12 CDC23

2.02e-045329410GO:0016755
GeneOntologyMolecularFunctionferroxidase activity

CP HEPH

3.25e-046942GO:0004322
GeneOntologyMolecularFunctionoxidoreductase activity, acting on metal ions, oxygen as acceptor

CP HEPH

3.25e-046942GO:0016724
GeneOntologyMolecularFunctionsmall GTPase binding

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 SORL1

8.05e-04321947GO:0031267
GeneOntologyMolecularFunctionenzyme activator activity

RGPD4 RGPD2 RANBP2 RGPD8 STXBP5 RGPD3 RGPD1 TAB1 NLRP3 RGPD5

1.03e-036569410GO:0008047
GeneOntologyMolecularFunctionGTPase binding

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 SORL1

1.56e-03360947GO:0051020
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

5.93e-139936GO:0033133
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.48e-1210936GO:1903301
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

2.22e-1220937GO:0006607
GeneOntologyBiologicalProcessregulation of glucokinase activity

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.19e-1113936GO:0033131
GeneOntologyBiologicalProcessregulation of hexokinase activity

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.08e-1114936GO:1903299
GeneOntologyBiologicalProcessprotein peptidyl-prolyl isomerization

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.75e-0838936GO:0000413
GeneOntologyBiologicalProcesshexose biosynthetic process

RGPD4 RGPD2 RANBP2 GNPDA1 RGPD8 RGPD3 RGPD1 FBP2

5.01e-08115938GO:0019319
GeneOntologyBiologicalProcessmonosaccharide biosynthetic process

RGPD4 RGPD2 RANBP2 GNPDA1 RGPD8 RGPD3 RGPD1 FBP2

7.46e-08121938GO:0046364
GeneOntologyBiologicalProcesspeptidyl-proline modification

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.55e-0754936GO:0018208
GeneOntologyBiologicalProcessgluconeogenesis

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 FBP2

6.99e-07111937GO:0006094
GeneOntologyBiologicalProcessregulation of gluconeogenesis

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

8.07e-0771936GO:0006111
GeneOntologyBiologicalProcessprotein folding

RGPD4 RGPD2 RANBP2 HSP90B2P RGPD8 RGPD3 RGPD1 TOR1A TTC4

1.70e-06246939GO:0006457
GeneOntologyBiologicalProcesscarbohydrate biosynthetic process

RGPD4 RGPD2 RANBP2 GNPDA1 RGPD8 RGPD3 RGPD1 FBP2 GSK3A

1.76e-06247939GO:0016051
GeneOntologyBiologicalProcesspositive regulation of transferase activity

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 TAB1 SERINC5 MERTK GSK3A AXIN1 AXIN2

2.06e-064909312GO:0051347
GeneOntologyBiologicalProcessregulation of carbohydrate biosynthetic process

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 GSK3A

2.25e-06132937GO:0043255
GeneOntologyBiologicalProcessregulation of glucose metabolic process

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 GSK3A

2.48e-06134937GO:0010906
GeneOntologyBiologicalProcesshexose metabolic process

RGPD4 RGPD2 RANBP2 GNPDA1 RGPD8 RGPD3 RGPD1 FBP2 GSK3A

5.49e-06284939GO:0019318
GeneOntologyBiologicalProcesspositive regulation of phosphorylation

AKAP6 RGPD4 RGPD2 RANBP2 RGPD8 PTPRJ RGPD3 RGPD1 TAB1 ITLN2 MERTK GSK3A AXIN1 AXIN2

1.01e-057809314GO:0042327
GeneOntologyBiologicalProcessmonosaccharide metabolic process

RGPD4 RGPD2 RANBP2 GNPDA1 RGPD8 RGPD3 RGPD1 FBP2 GSK3A

1.11e-05310939GO:0005996
GeneOntologyBiologicalProcesspositive regulation of kinase activity

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 TAB1 MERTK AXIN1 AXIN2

1.44e-054059310GO:0033674
GeneOntologyBiologicalProcessglucose metabolic process

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 FBP2 GSK3A

1.47e-05244938GO:0006006
GeneOntologyBiologicalProcessprotein import into nucleus

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

2.89e-05195937GO:0006606
GeneOntologyBiologicalProcessimport into nucleus

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

3.51e-05201937GO:0051170
GeneOntologyBiologicalProcesspositive regulation of phosphate metabolic process

AKAP6 RGPD4 RGPD2 RANBP2 RGPD8 PTPRJ RGPD3 RGPD1 TAB1 ITLN2 MERTK GSK3A AXIN1 AXIN2

3.80e-058799314GO:0045937
GeneOntologyBiologicalProcesspositive regulation of phosphorus metabolic process

AKAP6 RGPD4 RGPD2 RANBP2 RGPD8 PTPRJ RGPD3 RGPD1 TAB1 ITLN2 MERTK GSK3A AXIN1 AXIN2

3.80e-058799314GO:0010562
GeneOntologyBiologicalProcessmRNA transport

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

5.02e-05145936GO:0051028
GeneOntologyBiologicalProcesssmall molecule biosynthetic process

RGPD4 RGPD2 RANBP2 GNPDA1 RGPD8 MTHFR RGPD3 RGPD1 LTA4H FBP2 SERINC5 PDXK

5.13e-056769312GO:0044283
GeneOntologyBiologicalProcessregulation of transferase activity

RGPD4 RGPD2 RANBP2 RGPD8 PTPRJ RGPD3 RGPD1 TAB1 SERINC5 MERTK GSK3A AXIN1 AXIN2

6.84e-058109313GO:0051338
GeneOntologyBiologicalProcessregulation of carbohydrate metabolic process

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 GSK3A

8.44e-05231937GO:0006109
GeneOntologyBiologicalProcessprotein maturation

RGPD4 RGPD2 RANBP2 HSP90B2P RGPD8 RGPD3 RGPD1 TOR1A TTC4 NLRP3 SORL1

1.07e-046199311GO:0051604
GeneOntologyBiologicalProcessestablishment of protein localization to organelle

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 VPS13A RGPD1 GSK3A SORL1 RGPD5

1.09e-045159310GO:0072594
GeneOntologyBiologicalProcessRNA transport

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.42e-04175936GO:0050658
GeneOntologyBiologicalProcessnucleic acid transport

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.42e-04175936GO:0050657
GeneOntologyBiologicalProcesssarcomere organization

MYH6 BMP10 CASQ2 NEB

1.46e-0459934GO:0045214
GeneOntologyBiologicalProcesscarbohydrate metabolic process

RGPD4 RGPD2 RANBP2 GNPDA1 RGPD8 MLEC RGPD3 RGPD1 PYGL FBP2 GSK3A

1.55e-046469311GO:0005975
GeneOntologyBiologicalProcessestablishment of RNA localization

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.55e-04178936GO:0051236
GeneOntologyBiologicalProcessnuclear export

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.92e-04185936GO:0051168
GeneOntologyBiologicalProcessprotein retention in Golgi apparatus

VPS13A SORL1

1.99e-045932GO:0045053
GeneOntologyBiologicalProcesspost-Golgi vesicle-mediated transport

STXBP5 VPS13A EXOC1 PREPL SORL1

2.04e-04119935GO:0006892
GeneOntologyBiologicalProcesscardiac muscle cell development

AKAP6 MYH6 BMP10 NEB GSK3A

2.29e-04122935GO:0055013
GeneOntologyBiologicalProcessprotein localization to nucleus

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 TOR1A RGPD5

2.32e-04362938GO:0034504
GeneOntologyBiologicalProcessregulation of kinase activity

RGPD4 RGPD2 RANBP2 RGPD8 PTPRJ RGPD3 RGPD1 TAB1 MERTK AXIN1 AXIN2

2.61e-046869311GO:0043549
GeneOntologyBiologicalProcessnuclear transport

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 AXIN1 RGPD5

3.10e-04378938GO:0051169
GeneOntologyBiologicalProcessnucleocytoplasmic transport

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 AXIN1 RGPD5

3.10e-04378938GO:0006913
GeneOntologyBiologicalProcesscardiac cell development

AKAP6 MYH6 BMP10 NEB GSK3A

3.29e-04132935GO:0055006
GeneOntologyBiologicalProcessRNA localization

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

4.51e-04217936GO:0006403
GeneOntologyBiologicalProcesscontact inhibition

FAP PTPRJ

5.53e-048932GO:0060242
GeneOntologyBiologicalProcessatrial cardiac muscle tissue morphogenesis

MYH6 BMP10

5.53e-048932GO:0055009
GeneOntologyBiologicalProcessregulation of extracellular matrix organization

FAP LAMA1 PHLDB2 AXIN2

5.67e-0484934GO:1903053
GeneOntologyBiologicalProcessmyofibril assembly

MYH6 BMP10 CASQ2 NEB

6.20e-0486934GO:0030239
GeneOntologyBiologicalProcesspositive regulation of catalytic activity

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 TAB1 SERINC5 MERTK GSK3A NLRP3 AXIN1 AXIN2

6.94e-0410289313GO:0043085
GeneOntologyBiologicalProcessstriated muscle cell development

MYH6 BMP10 CASQ2 NEB

7.06e-0489934GO:0055002
GeneOntologyBiologicalProcesscellular anatomical entity morphogenesis

MYH6 BMP10 CASQ2 NEB PHLDB2

7.06e-04156935GO:0032989
GeneOntologyBiologicalProcesscellular component assembly involved in morphogenesis

MYH6 BMP10 CASQ2 NEB PHLDB2

7.06e-04156935GO:0010927
GeneOntologyBiologicalProcessdetection of cell density

FAP PTPRJ

7.09e-049932GO:0060245
GeneOntologyBiologicalProcessnucleobase-containing compound transport

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

9.25e-04249936GO:0015931
GeneOntologyBiologicalProcesscardiac muscle contraction

AKAP6 MYH6 BMP10 SCN9A CASQ2

9.59e-04167935GO:0060048
GeneOntologyBiologicalProcessproteasomal protein catabolic process

HSP90B2P TOR1A PSMD2 SEL1L2 ZNF598 GSK3A AXIN1 CDC23 AXIN2

1.04e-03567939GO:0010498
GeneOntologyBiologicalProcessregulation of basement membrane organization

LAMA1 PHLDB2

1.08e-0311932GO:0110011
GeneOntologyBiologicalProcessmuscle cell development

AKAP6 MYH6 BMP10 CASQ2 NEB GSK3A

1.13e-03259936GO:0055001
GeneOntologyBiologicalProcessregulation of phosphorylation

AKAP6 RGPD4 RGPD2 RANBP2 RGPD8 PTPRJ RGPD3 RGPD1 TAB1 ITLN2 MERTK GSK3A AXIN1 AXIN2

1.15e-0312269314GO:0042325
GeneOntologyBiologicalProcessdetection of biotic stimulus

FAP PTPRJ NLRP3

1.17e-0346933GO:0009595
GeneOntologyBiologicalProcesscardiac muscle cell differentiation

AKAP6 MYH6 BMP10 NEB GSK3A

1.24e-03177935GO:0055007
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.09e-138956GO:1990723
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.55e-1210956GO:0044614
GeneOntologyCellularComponentannulate lamellae

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.19e-1114956GO:0005642
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.33e-1018956GO:0044615
GeneOntologyCellularComponentnuclear inclusion body

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.76e-1020956GO:0042405
GeneOntologyCellularComponentSUMO ligase complex

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

3.86e-1021956GO:0106068
GeneOntologyCellularComponentnuclear pore

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

3.89e-07101957GO:0005643
GeneOntologyCellularComponentnuclear membrane

AKAP6 RGPD4 RGPD2 RANBP2 BRIP1 RGPD8 CENPF RGPD3 RGPD1 TOR1A AK9

5.37e-073499511GO:0031965
GeneOntologyCellularComponentnuclear envelope

AKAP6 RGPD4 RGPD2 RANBP2 BRIP1 RGPD8 CENPF RGPD3 RGPD1 TOR1A AK9 SORL1 RGPD5

1.49e-065609513GO:0005635
GeneOntologyCellularComponentinclusion body

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

3.44e-0690956GO:0016234
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

AKAP6 RGPD4 RGPD2 NBAS RANBP2 HSP90B2P REEP1 RGPD8 MLEC DNAJC16 RGPD3 VPS13A RGPD1 TOR1A CASQ2 TAB1 SEL1L2 GABBR1 SORL1

6.88e-0613279519GO:0042175
GeneOntologyCellularComponentperinuclear region of cytoplasm

AKAP6 RGPD4 RGPD2 RANBP2 HSP90B2P RGPD8 CENPF STK26 RGPD3 RGPD1 EXOC1 SERINC5 HEPH AXIN1 SORL1

1.96e-059349515GO:0048471
GeneOntologyCellularComponentbeta-catenin destruction complex

GSK3A AXIN1 AXIN2

2.52e-0513953GO:0030877
GeneOntologyCellularComponentorganelle envelope

AKAP6 RGPD4 RGPD2 RANBP2 HSP90B2P BRIP1 REEP1 RGPD8 CENPF RGPD3 VPS13A RGPD1 TOR1A AK9 GABBR1 SORL1 RGPD5

2.33e-0414359517GO:0031967
GeneOntologyCellularComponentZ disc

MYH6 BMP10 CASQ2 FBP2 NEB

6.32e-04151955GO:0030018
GeneOntologyCellularComponentjunctional sarcoplasmic reticulum membrane

AKAP6 CASQ2

8.98e-0410952GO:0014701
GeneOntologyCellularComponentI band

MYH6 BMP10 CASQ2 FBP2 NEB

9.69e-04166955GO:0031674
GeneOntologyCellularComponentmyofibril

MYH6 BMP10 PDE4DIP CASQ2 FBP2 NEB

1.55e-03273956GO:0030016
GeneOntologyCellularComponentcontractile muscle fiber

MYH6 BMP10 PDE4DIP CASQ2 FBP2 NEB

2.10e-03290956GO:0043292
MousePhenoabnormal morula morphology

RGPD4 RGPD2 RANBP2 RGPD8 POLR2B RGPD3 RGPD1 TTC4

1.16e-1226808MP:0012058
MousePhenoelevated level of mitotic sister chromatid exchange

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.22e-1016806MP:0003701
MousePhenodecreased tumor latency

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.55e-0830806MP:0010308
MousePhenofailure of blastocyst formation

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.91e-0831806MP:0012129
MousePhenoabnormal tumor latency

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

3.44e-0834806MP:0010307
MousePhenoabnormal blastocyst formation

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

8.15e-0839806MP:0012128
MousePhenoaneuploidy

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.26e-0661806MP:0004024
MousePhenoembryonic lethality before implantation, complete penetrance

RGPD4 RGPD2 RANBP2 RGPD8 POLR2B RGPD3 RGPD1 EXOC1 TTC4

2.29e-06203809MP:0011094
MousePhenofailure of blastocyst to hatch from the zona pellucida

RGPD4 RGPD2 RANBP2 RGPD8 POLR2B RGPD3 RGPD1

2.54e-06107807MP:0003694
MousePhenoincreased hepatocellular carcinoma incidence

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.85e-0670806MP:0003331
MousePhenoabnormal blastocyst hatching

RGPD4 RGPD2 RANBP2 RGPD8 POLR2B RGPD3 RGPD1

3.65e-06113807MP:0003693
MousePhenoabnormal rod electrophysiology

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 MERTK

5.16e-06119807MP:0004021
MousePhenoincreased lung carcinoma incidence

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

5.38e-0678806MP:0008714
MousePhenoabnormal gait

SLC6A2 BRIP1 REEP1 STXBP5 SLC26A4 VPS13A TOR1A CP NEB PREPL GSK3A GABBR1 SORL1

7.22e-065208013MP:0001406
MousePhenoabnormal chromosome morphology

RGPD4 RGPD2 RANBP2 BRIP1 RGPD8 RGPD3 RGPD1

7.53e-06126807MP:0003702
MousePhenoabnormal chromosome number

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

9.49e-0686806MP:0004023
MousePhenoembryonic lethality before implantation

RGPD4 RGPD2 RANBP2 RGPD8 POLR2B RGPD3 RGPD1 EXOC1 TTC4

9.58e-06242809MP:0006204
MousePhenoabnormal cell nucleus morphology

RGPD4 RGPD2 RANBP2 BRIP1 RGPD8 RGPD3 RGPD1 TOR1A

9.99e-06184808MP:0003111
MousePhenoenlarged epididymis

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.13e-0599806MP:0004931
MousePhenoincreased sarcoma incidence

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.53e-05102806MP:0002032
MousePhenoincreased respiratory system tumor incidence

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

3.32e-05107806MP:0010298
MousePhenoincreased lung tumor incidence

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

3.32e-05107806MP:0008014
MousePhenoabnormal preimplantation embryo morphology

RGPD4 RGPD2 RANBP2 RGPD8 POLR2B RGPD3 LAMA1 RGPD1 TTC4

3.32e-05283809MP:0014137
MousePhenoincreased physiological sensitivity to xenobiotic

SLC6A2 RGPD4 RGPD2 RANBP2 MYH6 RGPD8 RGPD3 RGPD1 EDIL3

3.60e-05286809MP:0008873
MousePhenoincreased hepatobiliary system tumor incidence

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

4.08e-05111806MP:0010297
MousePhenoincreased liver tumor incidence

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

4.08e-05111806MP:0008019
MousePhenoabnormal eye electrophysiology

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 LAMA1 RGPD1 MERTK

4.68e-05228808MP:0005551
MousePhenoabnormal preimplantation embryo development

RGPD4 RGPD2 RANBP2 RGPD8 POLR2B RGPD3 RGPD1

5.44e-05171807MP:0009781
MousePhenoabnormal mitosis

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

9.05e-05128806MP:0004046
MousePhenoincreased carcinoma incidence

RGPD4 RGPD2 RANBP2 BRIP1 RGPD8 RGPD3 RGPD1

1.32e-04197807MP:0002038
MousePhenoincreased incidence of tumors by chemical induction

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.54e-04141806MP:0004499
MousePhenoabnormal locomotor coordination

SLC6A2 BRIP1 REEP1 STXBP5 SLC26A4 VPS13A TOR1A CP NEB PREPL GSK3A GABBR1 SORL1

2.25e-047268013MP:0003312
MousePhenodecreased susceptibility to diet-induced obesity

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

3.06e-04160806MP:0005659
MousePhenoabnormal epididymis size

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

3.73e-04166806MP:0004926
MousePhenoincreased malignant tumor incidence

RGPD4 RGPD2 RANBP2 BRIP1 RGPD8 RGPD3 RGPD1

4.09e-04237807MP:0002018
MousePhenoincreased incidence of induced tumors

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

4.64e-04173806MP:0002021
MousePhenoabnormal embryo development

RGPD4 RGPD2 RANBP2 HSP90B2P GNPDA1 RGPD8 PTPRJ BMP10 POLR2B RGPD3 MED31 LAMA1 RGPD1 UTP3 TTC4 MED12 AXIN1 AXIN2

6.04e-0413708018MP:0001672
MousePhenodecreased susceptibility to weight gain

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

6.80e-04186806MP:0010182
MousePhenoabnormal incidence of induced tumors

RGPD4 RGPD2 RANBP2 RGPD8 PTPRJ RGPD3 RGPD1

8.67e-04269807MP:0013151
MousePhenoabnormal epididymis morphology

RGPD4 ULK3 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

8.67e-04269807MP:0002631
MousePhenoincreased energy expenditure

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

8.94e-04196806MP:0004889
MousePhenoabnormal intracellular organelle morphology

RGPD4 RGPD2 RANBP2 BRIP1 REEP1 RGPD8 RGPD3 VPS13A RGPD1 TOR1A

1.07e-035468010MP:0014239
DomainRan_BP1

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

4.68e-1412937PF00638
DomainRANBD1

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

4.68e-1412937PS50196
DomainRanBD

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

1.01e-1313937SM00160
DomainRan_bind_dom

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

1.01e-1313937IPR000156
DomainGrip

RGPD4 RGPD2 RGPD8 RGPD3 RGPD1 RGPD5

5.86e-1211936SM00755
DomainGRIP

RGPD4 RGPD2 RGPD8 RGPD3 RGPD1 RGPD5

5.86e-1211936PF01465
DomainTPR-contain_dom

WDR19 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 VPS13A RGPD1 STIP1 TTC4 CDC23 RGPD5

1.10e-111509312IPR013026
DomainGRIP_dom

RGPD4 RGPD2 RGPD8 RGPD3 RGPD1 RGPD5

1.17e-1112936IPR000237
DomainGRIP

RGPD4 RGPD2 RGPD8 RGPD3 RGPD1 RGPD5

1.17e-1112936PS50913
DomainTPR_REGION

WDR19 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 VPS13A RGPD1 STIP1 TTC4 CDC23 RGPD5

3.39e-111659312PS50293
DomainTPR

WDR19 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 VPS13A RGPD1 STIP1 TTC4 CDC23 RGPD5

3.39e-111659312PS50005
DomainGCC2_Rab_bind

RGPD4 RGPD2 RGPD8 RGPD3 RGPD1

5.72e-117935IPR032023
DomainRab_bind

RGPD4 RGPD2 RGPD8 RGPD3 RGPD1

5.72e-117935PF16704
Domain-

RGPD4 RGPD2 RGPD8 RGPD3 RGPD1

6.78e-10109351.10.220.60
DomainTPR-like_helical_dom

WDR19 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 STIP1 SEL1L2 TTC4 CDC23 RGPD5

1.83e-092339312IPR011990
Domain-

WDR19 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 STIP1 SEL1L2 TTC4 CDC23

6.55e-0920793111.25.40.10
DomainTPR

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 STIP1 TTC4 CDC23

1.59e-08129939SM00028
DomainTPR_repeat

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 STIP1 TTC4 CDC23

2.08e-08133939IPR019734
DomainTPR_1

RANBP2 RGPD8 RGPD1 STIP1 TTC4 CDC23 RGPD5

3.22e-0790937PF00515
DomainTPR_1

RANBP2 RGPD8 RGPD1 STIP1 TTC4 CDC23 RGPD5

3.22e-0790937IPR001440
DomainAxin_b-cat-bd

AXIN1 AXIN2

2.45e-052932IPR014936
DomainAxin_TNKS-bd

AXIN1 AXIN2

2.45e-052932IPR032101
DomainAXIN1_TNKS_BD

AXIN1 AXIN2

2.45e-052932PF16646
DomainAxin_b-cat_bind

AXIN1 AXIN2

2.45e-052932PF08833
DomainPH_dom-like

RGPD4 RGPD2 FRMD4A RANBP2 RGPD8 RGPD3 RGPD1 PLEKHD1 PHLDB2 RGPD5

5.13e-054269310IPR011993
DomainMULTICOPPER_OXIDASE2

CP HEPH

7.33e-053932PS00080
DomainCu-oxidase

CP HEPH

7.33e-053932PF00394
DomainCu-oxidase

CP HEPH

7.33e-053932IPR001117
Domain-

RGPD4 RGPD2 FRMD4A RANBP2 RGPD8 RGPD3 RGPD1 PLEKHD1 PHLDB2

1.44e-043919392.30.29.30
DomainCu-oxidase_2

CP HEPH

1.46e-044932IPR011706
DomainCu-oxidase_2

CP HEPH

1.46e-044932PF07731
DomainCu_oxidase_CS

CP HEPH

2.43e-045932IPR033138
DomainPRO_ENDOPEP_SER

FAP PREPL

2.43e-045932PS00708
DomainCu-oxidase_3

CP HEPH

2.43e-045932IPR011707
DomainMULTICOPPER_OXIDASE1

CP HEPH

2.43e-045932PS00079
DomainCu-oxidase_3

CP HEPH

2.43e-045932PF07732
DomainCu_oxidase_Cu_BS

CP HEPH

3.63e-046932IPR002355
DomainHaem_d1

WDR19 STXBP5

3.63e-046932IPR011048
DomainTPR_11

STIP1 CDC23

5.07e-047932PF13414
DomainDIX

AXIN1 AXIN2

5.07e-047932PF00778
DomainDIX

AXIN1 AXIN2

5.07e-047932IPR001158
DomainDIX

AXIN1 AXIN2

5.07e-047932PS50841
DomainDAX

AXIN1 AXIN2

5.07e-047932SM00021
DomainPeptidase_S9

FAP PREPL

1.31e-0311932PF00326
DomainPeptidase_S9

FAP PREPL

1.31e-0311932IPR001375
Domain-

CP HEPH

2.15e-03149322.60.40.420
PathwayBIOCARTA_RANBP2_PATHWAY

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

3.54e-1018766MM1549
PathwayREACTOME_GLUCOSE_METABOLISM

RGPD4 RGPD2 RANBP2 GNPDA1 RGPD8 RGPD3 RGPD1 FBP2

1.27e-0882768MM15394
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

6.67e-0840766MM14945
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

7.78e-0841766MM15200
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

9.03e-0842766MM15039
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.05e-0743766MM14609
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.81e-0747766MM14939
PathwayREACTOME_MITOTIC_SPINDLE_CHECKPOINT

RGPD4 RGPD2 RANBP2 RGPD8 CENPF RGPD3 RGPD1 CDC23

2.08e-07117768MM15387
PathwayREACTOME_GENE_SILENCING_BY_RNA

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.34e-0749766MM14837
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.64e-0750766MM14610
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.98e-0751766MM15151
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

4.72e-0755766MM14917
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

6.51e-0758766MM15149
PathwayREACTOME_SNRNP_ASSEMBLY

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

6.51e-0758766MM14736
PathwayREACTOME_SEPARATION_OF_SISTER_CHROMATIDS

RGPD4 RGPD2 RANBP2 RGPD8 CENPF RGPD3 RGPD1 PSMD2 CDC23

9.06e-07193769MM14890
PathwayREACTOME_AMPLIFICATION_OF_SIGNAL_FROM_THE_KINETOCHORES

RGPD4 RGPD2 RANBP2 RGPD8 CENPF RGPD3 RGPD1

1.07e-06100767MM14561
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.29e-0665766MM15147
PathwayREACTOME_CELL_CYCLE_CHECKPOINTS

RGPD4 RGPD2 RANBP2 BRIP1 RGPD8 CENPF RGPD3 RGPD1 PSMD2 CDC23

1.82e-062717610MM15388
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.57e-0673766MM14948
PathwayREACTOME_MITOTIC_METAPHASE_AND_ANAPHASE

RGPD4 RGPD2 RANBP2 RGPD8 CENPF RGPD3 RGPD1 PSMD2 CDC23

4.45e-06234769MM14898
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

5.85e-0684766MM14929
PathwayREACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION

RGPD4 RGPD2 RANBP2 RGPD8 CENPF RGPD3 RGPD1

5.91e-06129767MM14894
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

6.71e-0686766MM15413
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

9.92e-0692766MM14951
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

RGPD4 RGPD2 RANBP2 RGPD8 CENPF RGPD3 RGPD1

1.06e-05141767MM15266
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

RGPD4 RGPD2 RANBP2 GNPDA1 RGPD8 RGPD3 RGPD1 PYGL FBP2

1.45e-05271769MM15406
PathwayREACTOME_MITOTIC_PROPHASE

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

3.38e-05114766MM15361
PathwayREACTOME_MITOTIC_PROMETAPHASE

RGPD4 RGPD2 RANBP2 RGPD8 CENPF RGPD3 RGPD1

1.06e-04202767MM15362
PathwayPID_BETA_CATENIN_DEG_PATHWAY

GSK3A AXIN1 AXIN2

1.16e-0418763M31
PathwayREACTOME_SLC_TRANSPORTER_DISORDERS

SLC6A2 RANBP2 SLC26A4 CP HEPH

1.92e-0499765M27474
PathwayREACTOME_M_PHASE

RGPD4 RGPD2 RANBP2 RGPD8 CENPF RGPD3 RGPD1 PSMD2 CDC23

2.26e-04387769MM15364
PathwayREACTOME_SUMOYLATION

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.97e-04169766MM14919
PathwayREACTOME_CELLULAR_RESPONSES_TO_STIMULI

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 CHD9 PSMD2 STIP1 CDC23

3.64e-045057610MM15548
PathwayREACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS

SLC6A2 RANBP2 SLC26A4 PSMD2 CP HEPH

3.80e-04177766M27476
PathwayREACTOME_RHO_GTPASE_EFFECTORS

RGPD4 RGPD2 RANBP2 RGPD8 CENPF RGPD3 RGPD1

4.62e-04257767MM14755
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

RGPD4 RGPD2 RANBP2 RGPD8 POLR2B RGPD3 RGPD1

7.21e-04277767MM15414
PathwayREACTOME_CELL_CYCLE

RGPD4 RGPD2 RANBP2 BRIP1 RGPD8 CENPF RGPD3 RGPD1 PSMD2 CDC23

1.42e-036037610MM14635
PathwayREACTOME_METABOLISM_OF_RNA

RGPD4 RGPD2 RANBP2 RGPD8 POLR2B RGPD3 RGPD1 PSMD2 UTP3 PAN3

1.59e-036127610MM15547
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_APC_TO_WNT_SIGNALING_PATHWAY

AXIN1 AXIN2

1.83e-0312762M47410
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-1579569037092
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD4 RGPD2 RGPD8 RGPD3 RGPD1 RGPD5

2.47e-15795615710750
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-15795611353387
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-15795630944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-15795638838144
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-1579567559465
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-15795617372272
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-15795638657106
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-15795621205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-15795618949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-15795625187515
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-1579568603673
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-15795626632511
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-15795624403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-15795623818861
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-15795623536549
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-15795612191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-15795622821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.47e-15795620682751
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 LAMA1 RGPD1

5.72e-151595714697343
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

9.86e-15895621670213
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

9.86e-15895627412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

9.86e-15895621310149
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

9.86e-15895622262462
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

9.86e-15895628745977
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.95e-14995618394993
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.95e-14995628100513
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.95e-14995617887960
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.95e-14995611553612
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.95e-14995610601307
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.95e-1499569733766
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.95e-14995628877029
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

7.36e-141095627160050
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

7.36e-141095616332688
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

7.36e-14109568857542
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

7.36e-141095621859863
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.62e-131195617069463
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.62e-131195635771867
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.62e-131195634110283
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

5.98e-131395631427429
Pubmed

Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.55e-112295627717094
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

RGPD4 RGPD2 FRMD4A RANBP2 HSP90B2P REEP1 RGPD8 MLEC DNAJC16 RGPD3 PDE4DIP RGPD1 PSMD2 EXOC1 STIP1 TAB1 GSK3A GABBR1 PDXK

2.27e-101139951936417873
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

9.10e-103895612791264
Pubmed

The protein interaction landscape of the human CMGC kinase group.

RANBP2 STK26 POLR2B MED31 LAMA1 STIP1 NEB EDIL3 NOP2 MED12 GSK3A AXIN1 AXIN2 SORL1

6.55e-09695951423602568
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

RGPD4 RGPD2 RANBP2 MYH6 RGPD8 MLEC RGPD3 RGPD1 PSMD2 PYGL STIP1 TAB1 NEB NOP2 RGPD5

9.59e-09844951525963833
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

RGPD4 RGPD2 RANBP2 RGPD8 HSPBAP1 RGPD3 RGPD1 CDC23

1.03e-0815395826365490
Pubmed

Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 NOP2

1.10e-089995727746211
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

RGPD4 RGPD2 RANBP2 RGPD8 MLEC STK26 POLR2B RGPD3 RGPD1 PSMD2 PYGL TTC4 NOP2 MED12 PDXK CDC23 RGPD5

4.93e-081257951737317656
Pubmed

Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.

RANBP2 RGPD8 RGPD5

7.88e-0849539480752
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

1.40e-078695637253089
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

RGPD4 RGPD2 RGPD8 STK26 RGPD3 RGPD1 PAN3 RGPD5

1.43e-0721595835973513
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

RGPD4 RGPD2 RANBP2 RGPD8 POLR2B RGPD3 RGPD1

1.61e-0714695723892456
Pubmed

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

RGPD4 RGPD2 RANBP2 UBTFL6 REEP1 BMP10 RGPD3 RGPD1 ZC3H6 RGPD5

3.83e-07442951015815621
Pubmed

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

GSK3A AXIN1 AXIN2

3.93e-07695319759537
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

RGPD4 RGPD2 NBAS RANBP2 RGPD8 CENPF STK26 RGPD3 RGPD1 PROSER1 EDIL3 NOP2 CDC23 RGPD5 RAVER1

5.54e-071155951520360068
Pubmed

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.

GSK3A AXIN1 AXIN2

1.64e-0699539601641
Pubmed

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

2.00e-0613595631077711
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RGPD4 RGPD2 RANBP2 RGPD8 CENPF RGPD3 RGPD1 MED12 CDC23

2.27e-0641895934709266
Pubmed

Gsk3β is required in the epithelium for palatal elevation in mice.

EDIL3 GSK3A AXIN2

2.34e-061095320981831
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

RANBP2 HSP90B2P MLEC DNAJC16 ANXA3 PSMD2 PYGL STIP1 TAB1 ZNF598 NOP2 PREPL SORL1

2.52e-06974951328675297
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

NBAS RGPD8 CENPF POLR2B VPS13A PSMD2 PROSER1 STIP1 TAB1 UTP3 ZNF598 TTC4 NOP2 PREPL CDC23 RAVER1

2.82e-061496951632877691
Pubmed

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 STIP1

3.03e-0622695737839992
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 GABBR1

3.50e-0623195716452087
Pubmed

Scanning the human proteome for calmodulin-binding proteins.

AKAP6 RANBP2 POLR2B PSMD2 NEB

5.57e-069295515840729
Pubmed

Beta-catenin is temporally regulated during normal liver development.

GSK3A AXIN1 AXIN2

7.03e-061495315057752
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

RANBP2 STK26 POLR2B CHD9 PSMD2 STIP1 ZNF598 ZC3H6 MED12 GSK3A PHLDB2 AXIN1 AXIN2 RAVER1

7.35e-061247951427684187
Pubmed

Deletion of hephaestin and ceruloplasmin induces a serious systemic iron deficiency and disrupts iron homeostasis.

CP HEPH

7.38e-06295230060949
Pubmed

MST4 attenuates NLRP3 inflammasome-mediated neuroinflammation and affects the prognosis after intracerebral hemorrhage in mice.

STK26 NLRP3

7.38e-06295234534636
Pubmed

Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.

CP HEPH

7.38e-06295222342521
Pubmed

The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration.

CP HEPH

7.38e-06295221051716
Pubmed

Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.

CP HEPH

7.38e-06295226303407
Pubmed

Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes.

CP HEPH

7.38e-06295229355933
Pubmed

Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.

CP HEPH

7.38e-06295227991585
Pubmed

Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway.

AXIN1 AXIN2

7.38e-06295211809808
Pubmed

Axin2 regulates chondrocyte maturation and axial skeletal development.

AXIN1 AXIN2

7.38e-06295219623616
Pubmed

Genetic Ablation of STE20-Type Kinase MST4 Does Not Alleviate Diet-Induced MASLD Susceptibility in Mice.

STK26 EDIL3

7.38e-06295238397122
Pubmed

Upregulated of ANXA3, SORL1, and Neutrophils May Be Key Factors in the Progressionof Ankylosing Spondylitis.

ANXA3 SORL1

7.38e-06295235464477
Pubmed

Axin1 and Axin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways.

AXIN1 AXIN2

7.38e-06295218083923
Pubmed

Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer.

AXIN1 AXIN2

7.38e-06295215042511
Pubmed

Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.

CP HEPH

7.38e-06295218326691
Pubmed

Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain.

CP HEPH

7.38e-06295225788583
Pubmed

Significant Associations between AXIN1 rs1805105, rs12921862, rs370681 Haplotypes and Variant Genotypes of AXIN2 rs2240308 with Risk of Congenital Heart Defects.

AXIN1 AXIN2

7.38e-06295233096676
Pubmed

Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration.

CP HEPH

7.38e-06295215365174
Pubmed

Whole genome sequencing identifies ANXA3 and MTHFR mutations in a large family with an unknown equinus deformity associated genetic disorder.

MTHFR ANXA3

7.38e-06295227475959
Pubmed

Mutations in Lama1 disrupt retinal vascular development and inner limiting membrane formation.

LAMA1 EDIL3

7.38e-06295220048158
Pubmed

Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux.

CP HEPH

7.38e-06295229883959
Pubmed

Laminin α1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGF-β pathway.

LAMA1 EDIL3

7.38e-06295224720953
Pubmed

Cocaine increases quantal norepinephrine secretion through NET-dependent PKC activation in locus coeruleus neurons.

SLC6A2 EDIL3

7.38e-06295235977516
Pubmed

Functional role of laminin α1 chain during cerebellum development.

LAMA1 EDIL3

7.38e-06295222274713
Pubmed

Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation.

AXIN1 AXIN2

7.38e-06295228107521
Pubmed

Iron induced oxidative damage as a potential factor in age-related macular degeneration: the Cogan Lecture.

CP HEPH

7.38e-06295217065470
Pubmed

Multi-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes.

CP HEPH

7.38e-06295231263155
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

CENPF POLR2B SCN9A CHD9 AK9 UTP3 NEB MED12 CDC23

9.16e-0649795936774506
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

RGPD4 RGPD2 RANBP2 RGPD8 CENPF RGPD3 PDE4DIP RGPD1 STIP1 NOP2 PREPL PHLDB2

1.26e-05963951228671696
Pubmed

Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.

GSK3A AXIN1 AXIN2

1.31e-051795317510365
Pubmed

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.

AKAP6 PSMD2 STIP1 MUC13 MED12 SORL1

1.65e-0519595617110338
Pubmed

Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling.

PDE3A LAMA1 CP AXIN2

2.12e-055995431351040
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

RANBP2 STXBP5 POLR2B RGPD1 CP TAB1 PAN3 FCHO2 ZNF598 GSK3A RAVER1

2.17e-05853951128718761
Pubmed

Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines.

AXIN1 AXIN2

2.21e-05395233811251
Pubmed

Ferroportin and exocytoplasmic ferroxidase activity are required for brain microvascular endothelial cell iron efflux.

CP HEPH

2.21e-05395223640881
InteractionRGPD4 interactions

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

6.65e-1222957int:RGPD4
InteractionRGPD2 interactions

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

3.40e-1127957int:RGPD2
InteractionRGPD1 interactions

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 GSK3A RGPD5

6.95e-1149958int:RGPD1
InteractionRGPD8 interactions

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 PSMD2 RGPD5

2.11e-0974958int:RGPD8
InteractionRGPD3 interactions

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

2.23e-0947957int:RGPD3
InteractionRGPD5 interactions

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 PSMD2 RGPD5

1.71e-0896958int:RGPD5
InteractionNPIPB6 interactions

RANBP2 RGPD8 RGPD1 RGPD5

1.35e-0618954int:NPIPB6
InteractionNOX5 interactions

MTHFR STIP1 TTC4

3.56e-0514953int:NOX5
InteractionSYNE3 interactions

NBAS RANBP2 MLEC DNAJC16 TOR1A PROSER1 PAN3 ZNF598 CDC23 RAVER1

4.63e-054449510int:SYNE3
InteractionRANBP2 interactions

RGPD4 RGPD2 RANBP2 ARID4B RGPD8 RGPD3 RGPD1 STIP1 RGPD5

5.21e-05361959int:RANBP2
Cytoband2q13

RGPD8 RGPD3 ZC3H6 RGPD5

1.27e-05689542q13
CytobandEnsembl 112 genes in cytogenetic band chr2q13

RANBP2 MERTK RGPD5

2.57e-0459953chr2q13
Cytoband2p11.2

RGPD2 REEP1 RGPD1

3.26e-04649532p11.2
Cytoband2q12.3

RGPD4 RANBP2

5.65e-04179522q12.3
Cytoband16q12.2

SLC6A2 CHD9

1.33e-032695216q12.2
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 STIP1 TTC4 CDC23 RGPD5

7.01e-121156310769
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1 GALNT12

2.41e-1133947MM477
CoexpressionTABULA_MURIS_SENIS_TRACHEA_GRANULOCYTE_AGEING

RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD1

9.91e-0943946MM3857
CoexpressionGSE17974_0H_VS_48H_IN_VITRO_ACT_CD4_TCELL_UP

WDR19 EFHC2 PTPRJ STXBP5 CHD9 GABBR1 SORL1

6.06e-06192947M4174
CoexpressionFOSTER_TOLERANT_MACROPHAGE_DN

RGPD4 RGPD2 FRMD4A RANBP2 RGPD8 PTPRJ RGPD3 RGPD1 CP

2.69e-05435949MM1221
CoexpressionGSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_UP

FRMD4A STXBP5 CHD9 LTA4H MUC13 PAN3

3.94e-05174946M6877
CoexpressionHOUNKPE_HOUSEKEEPING_GENES

RGPD4 RGPD2 RANBP2 HSP90B2P RGPD8 MLEC RGPD3 RGPD1 TOR1A STIP1 TAB1 UTP3 GSK3A CDC23

6.40e-0511589414MM1338
CoexpressionGSE360_CTRL_VS_L_DONOVANI_DC_UP

GNPDA1 MTHFR DNAJC16 LTA4H MED12 SORL1

8.30e-05199946M5143
CoexpressionGSE32986_GMCSF_VS_GMCSF_AND_CURDLAN_HIGHDOSE_STIM_DC_UP

STXBP5 ANXA3 ST6GAL1 MERTK PREPL PDXK

8.54e-05200946M8630
CoexpressionGSE29618_MONOCYTE_VS_MDC_UP

PYGL LTA4H CD46 NLRP3 PDXK SORL1

8.54e-05200946M4948
CoexpressionGSE12392_WT_VS_IFNB_KO_CD8A_NEG_SPLEEN_DC_DN

PTPRJ PDE4DIP CHD9 PYGL LTA4H SORL1

8.54e-05200946M7150
ToppCellsevere-immature_Neutrophil|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CENPF STXBP5 ANXA3 SCN9A PYGL LTA4H GABBR1

2.45e-07200957a9b87accdaa6956116ab82427e1330e8f007ef94
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 RANBP2 MYH6 PDE3A CHD9 FCHO2

2.14e-06176956749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellBAL-Severe-cDC_0|Severe / Compartment, Disease Groups and Clusters

FRMD4A PYGL LTA4H FCHO2 PDXK SORL1

4.35e-06199956d39be8b173156bf87baddd3caed4b35597c53ea1
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 PDE3A HSP90B2P CASQ2 EDIL3

1.87e-051529550cb5f4dfae04e3f4eba502bbf229007d5fa3884d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 PDE3A HSP90B2P CASQ2 EDIL3

1.87e-05152955ba89ffb5a8bb33c188f854f54b39123b6d73496a
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

KBTBD3 TAB1 ITLN2 MERTK PHLDB2

3.11e-05169955665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

KBTBD3 TAB1 ITLN2 MERTK PHLDB2

3.11e-051699556614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCellCOVID-19-Heart-CM_+_Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 MYH6 PDE3A PDE4DIP CASQ2

3.20e-051709553f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCellCOVID-19-Heart-CM_+_Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

AKAP6 PTPRJ PDE4DIP CASQ2 MERTK

3.20e-051709554232fe937909f93d3736988c707b8f95ce993398
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

AKAP6 PDE3A CASQ2 EDIL3 RGPD5

3.47e-05173955a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCellCOVID-19-Heart-CM_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 MYH6 PDE3A PDE4DIP CASQ2

3.77e-051769559df7a124ebafb0087da0cda133a394275d7bed81
ToppCellAT1_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

REEP1 ANXA3 ITLN2 EDIL3 PHLDB2

3.77e-05176955458720776b0151cd55acc352d509599cb62f0ca8
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RGPD2 FRMD4A STXBP5 ST6GAL1 NLRP3

4.09e-0517995587f608b137aae34572b150492a83a3a127cff40b
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 MYH6 PDE3A PDE4DIP CASQ2

4.31e-05181955719eb532453ab7cd7893726885bc75d74a10b21e
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SERINC5 PREPL AXIN2 SORL1 RGPD5

4.66e-051849555350b58aa9979631228835d11eb45ddf81d08bff
ToppCellCOVID-19-Heart-CM_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 MYH6 PDE3A PDE4DIP CASQ2

4.78e-05185955549eeb521c3985bff396ea0f202db21822efa51f
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

AKAP6 FRMD4A SCN9A ST6GAL1 MERTK

4.78e-051859558207f9eff113eed429e961748c6b17d672a13b33
ToppCellInfluenza-Influenza_Severe-Myeloid-Neutrophil|Influenza_Severe / Disease, condition lineage and cell class

STXBP5 ANXA3 SLC26A4 PYGL SORL1

4.91e-051869551dfcec9196d4db76fba3abc74e85885b1fb98b87
ToppCell343B-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

AKAP6 PTPRJ SCN9A ST6GAL1 MERTK

4.91e-051869559673367cb53bafb873a01ef6bda11d9f392ce648
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

AKAP6 PDE3A CASQ2 EDIL3 PHLDB2

5.03e-05187955464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

AKAP6 MYH6 PDE4DIP CASQ2 NEB

5.16e-051889556d249fe92d51a19da19ec14bb2262d394255d577
ToppCellPericytes-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

PDE3A CASQ2 SEL1L2 EDIL3 PHLDB2

5.16e-0518895514c1c88a944c66f2eaac1ce7526815dcce1f5147
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 FRMD4A PDE3A CASQ2 EDIL3

5.29e-051899557fbe855bfdb47d35e040b04a80fe4b729a3764e8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 FRMD4A PDE3A CASQ2 EDIL3

5.29e-0518995506b35abecd29f902cf251fcc1f6ad33db7ab08a2
ToppCellRV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

AKAP6 PDE3A PDE4DIP CASQ2 PHLDB2

5.29e-051899550a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

AKAP6 PDE3A PDE4DIP CASQ2 PHLDB2

5.43e-0519095593c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

AKAP6 FRMD4A SCN9A MERTK NLRP3

5.43e-05190955f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FRMD4A ANXA3 CD46 EDIL3 PDXK

5.43e-05190955a5db902ad112a0c0a0a7f1a2e38718bb3bd11412
ToppCellPBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

STXBP5 ANXA3 PYGL LTA4H GABBR1

5.56e-051919556c1283d51a845cff67ed5e500f7e944165297b53
ToppCelldroplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 MYH6 BMP10 PDE4DIP CASQ2

5.56e-0519195597fb4232417a39801e87725755fd16a57c250209
ToppCelldroplet-Heart-nan-3m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 MYH6 BMP10 PDE4DIP CASQ2

5.56e-0519195564070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

AKAP6 MYH6 PDE3A PDE4DIP CASQ2

5.84e-05193955dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCellRA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

AKAP6 MYH6 BMP10 PDE4DIP CASQ2

5.99e-0519495589812fb164065041357bb37a3c2d87028ec3de4e
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|390C / Donor, Lineage, Cell class and subclass (all cells)

KBTBD3 TAB1 ITLN2 MERTK PHLDB2

5.99e-0519495588db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|390C / Donor, Lineage, Cell class and subclass (all cells)

KBTBD3 TAB1 ITLN2 MERTK PHLDB2

5.99e-05194955a71728202493d4858342ea2756ea281cd0d99a3a
ToppCellCOVID-19-Heart-CM_2|Heart / Disease (COVID-19 only), tissue and cell type

AKAP6 MYH6 PDE3A PDE4DIP CASQ2

6.14e-0519595575fc81bddb246dca3b437fb60827b1d4fe416405
ToppCellFibroblasts-Pericytes|Fibroblasts / lung cells shred on cell class, cell subclass, sample id

SLC6A2 FRMD4A PDE3A CASQ2 EDIL3

6.14e-05195955c2ebc0b33bda9b35b9ef26d69e5d2c6acfdb6ff1
ToppCellsevere-Myeloid-Immature_Neutrophils_1|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ANXA3 PYGL LTA4H GABBR1 PDXK

6.14e-05195955becad890a420267ca41e98e61a8da343b51e1945
ToppCell343B-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

AKAP6 PTPRJ SCN9A ST6GAL1 MERTK

6.14e-0519595567b05a0cd2ca9924eca81a92cc6330eecb9d963c
ToppCellSecretory|World / shred by cell class for bronchial biopsy

PSMD2 CP ST6GAL1 MUC13 SORL1

6.14e-0519595552f8281fe0df67cec3faa780a23ed6343ed5a6ba
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MLEC SLC26A4 CP ST6GAL1 MUC13

6.29e-051969552c3fbfbb08cd327cd97b3fa5a6f83b6d50771fb7
ToppCell367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

AKAP6 SCN9A ST6GAL1 MERTK NLRP3

6.29e-05196955e8c4eeb4b6c6d9bccca2adb942d4cfbaab39636c
ToppCellCOVID-19-Heart-Mito_CM|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 MYH6 PDE4DIP CASQ2 NEB

6.44e-0519795544e49943d62bfe622b40ad0460093d31540544df
ToppCelldistal-Hematologic-IGSF21+_Dendritic-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PTPRJ SCN9A ST6GAL1 MERTK NLRP3

6.44e-05197955e77c91f5a1f5a292eda41abf3b1e31180f2c61e1
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 PDE3A REEP1 CASQ2 EDIL3

6.44e-05197955ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCelldistal-3-Hematologic-IGSF21+_Dendritic|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PTPRJ SCN9A ST6GAL1 MERTK NLRP3

6.44e-0519795552e9dc35dd8cc2605fa4894bb16bb5c6086faa76
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 FRMD4A PDE3A CASQ2 PHLDB2

6.60e-05198955f261a37dd07976548b897af86df1d1a0dc069889
ToppCelldistal-Hematologic-IGSF21+_Dendritic-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SCN9A ST6GAL1 FCHO2 MERTK NLRP3

6.60e-05198955323b4e6c31e18227546bb30566c1d872fda45e36
ToppCell10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-neutrophil-myelocyte|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ANXA3 PYGL LTA4H PDXK SORL1

6.60e-051989553bc05b8d97a7219af40db7a11aa271f02e74fca5
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 PDE3A REEP1 CASQ2 EDIL3

6.60e-05198955c12e7511628db819a52959bb68580e27c00c2e41
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 PDE3A REEP1 CASQ2 EDIL3

6.60e-0519895522e766df1276c5b14aa0d83f434f47140ebb98ea
ToppCell10x5'v1-week_17-19-Myeloid_macrophage|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

AKAP6 FRMD4A GNPDA1 PDE4DIP MERTK

6.75e-05199955980b10b81ee9dc952e3be25bd294201ce5a4ca8b
ToppCell10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil-myelocyte|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ANXA3 PYGL LTA4H PDXK SORL1

6.75e-05199955a1635a52318be0423f8e4fc03d971c28cd22b57e
ToppCellNS-control-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CHD9 CP GALNT12 ST6GAL1 SORL1

6.75e-0519995532bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCell10x5'v1-week_17-19-Myeloid_macrophage-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

AKAP6 FRMD4A GNPDA1 PDE4DIP MERTK

6.75e-05199955cbd423c31d75f6d2f5ae85d2241641fcbe630b81
ToppCellCOVID-19_Severe-immature_Neutrophil|COVID-19_Severe / Disease condition and Cell class

BRIP1 CENPF STXBP5 ANXA3 PYGL

6.75e-05199955f82fa9d651e78f9ebbe6264e00a48c54b1786a69
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

NBAS PTPRJ STXBP5 PAN3 NAALADL2

6.75e-0519995594b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellCOVID-19_Severe-immature_Neutrophil-|COVID-19_Severe / Disease condition and Cell class

BRIP1 CENPF STXBP5 ANXA3 PYGL

6.75e-0519995542ea0c19c455bdb0ae89b428d09c333104c670dc
ToppCellcontrol-Epithelial-Secretory|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CHD9 CP GALNT12 ST6GAL1 SORL1

6.75e-051999553d01f90ffd271ca00129192787e4921bdca7e01e
ToppCellcontrol-Epithelial-Secretory|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CHD9 CP GALNT12 ST6GAL1 SORL1

6.75e-05199955262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCellTracheal-NucSeq-Stromal-Chondrocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PDE3A STK26 PDE4DIP PYGL EDIL3

6.92e-05200955b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCellCOVID-19-COVID-19_Severe-Myeloid-immature_Neutrophil|COVID-19_Severe / Disease, condition lineage and cell class

STXBP5 ANXA3 PYGL LTA4H GABBR1

6.92e-05200955cbe667eda1af222467df8bfa157aa22df488f133
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

FRMD4A PTPRJ ST6GAL1 MERTK SORL1

6.92e-05200955a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

FRMD4A PTPRJ ST6GAL1 MERTK SORL1

6.92e-05200955dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellTracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PDE3A STK26 PDE4DIP PYGL EDIL3

6.92e-05200955f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

FRMD4A PTPRJ ST6GAL1 MERTK SORL1

6.92e-052009553bba5219453322198e8fdb0921d5f8c403598751
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

FRMD4A PTPRJ ST6GAL1 MERTK SORL1

6.92e-0520095521bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte|LPS_only / Treatment groups by lineage, cell group, cell type

AKAP6 FRMD4A PDE3A CASQ2 EDIL3

6.92e-052009558c8ef2b19ab5b1bfc0fae6c38a330f464f28e86f
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

FRMD4A PTPRJ ST6GAL1 MERTK SORL1

6.92e-05200955a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

FRMD4A PTPRJ ST6GAL1 MERTK SORL1

6.92e-0520095533036d21c1c82109284473a515c4f890b33fdd5c
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A2 RGPD4 REEP1 SLC26A4

2.05e-041369547cd22169fb71c6caf9feb203ad98be8480a54fba
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NLRP9 SLC26A4 PSMD2 ZNF112

2.91e-0414995461d84838a841ed2d6b8c5f86d423a4e6b3dcc9cb
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RGPD2 SCN9A CLRN1 SORL1

3.14e-041529540652ee3443e6fbb679d2c4f326239ae7c803f924
ToppCell368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PYGL MERTK AXIN2 RGPD5

3.14e-04152954ca23261d8ef263cc697b8d7e7cb2afec8bc564f2
ToppCellSevere-B_naive-5|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

RGPD3 PYGL SERINC5 AXIN2

3.22e-0415395444572f87d403e314050ab935d2cd676c33d9c287
ToppCellfacs-Heart-Unknown-3m-Myeloid-monocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 REEP1 BMP10 C8B

3.55e-041579548d30d8e6fae93afcada6bd68799439335cd65b69
ToppCellfacs-Heart-Unknown-3m-Myeloid|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 REEP1 BMP10 C8B

3.55e-041579542ac4695d9e4ca8d4ba19c555e9a1d86ac8f398ab
ToppCellfacs-Heart-Unknown-3m-Myeloid-monocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 REEP1 BMP10 C8B

3.55e-041579548a393eece90fb9a1b7c356736bdb36277261fbd3
ToppCellSevere-B_naive-5|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

RGPD3 PYGL SERINC5 AXIN2

3.55e-04157954a57ee4a6febdff3ee3d1645836695e6e7c055cf8
ToppCellfrontal_cortex-Non-neuronal-smooth_muscle_cell|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE3A ANXA3 CASQ2 PHLDB2

3.64e-0415895408806240228c5b780f5aef92ce2c278ae4d797cc
ToppCellfrontal_cortex-Non-neuronal-smooth_muscle_cell-SMC-SMC_Acta2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE3A ANXA3 CASQ2 PHLDB2

3.64e-04158954496b6988f7b3439968351840ae22f56ffa1643f1
ToppCellfrontal_cortex-Non-neuronal-smooth_muscle_cell-SMC|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE3A ANXA3 CASQ2 PHLDB2

3.64e-041589545b3d30f92b619f14a7b48502170000fa5783358a
ToppCellfacs-Heart-RV-3m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP10 PYGL NLRP3 SORL1

3.64e-041589542a222301474c4dfd9a776e197c10f4c1cacceb62
ToppCellfacs-Heart-RV-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP10 PYGL NLRP3 SORL1

3.64e-04158954ff9878fd768f22bf2ee4805bac2ba01cb3cb804a
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP10 PYGL NLRP3 SORL1

3.64e-04158954d43b335e6aa12d84a75b988fbd6127ff1f4af25c
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP10 PYGL NLRP3 SORL1

3.64e-04158954ab12b29ce51ca2fcac469cc932391217d97145f9
ToppCell368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

PYGL MERTK AXIN2 RGPD5

3.81e-0416095419105debef96ea0c267d6a1d332303ec668ae47e
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PTPRJ FCHO2 MERTK PREPL

3.81e-04160954709ce00699ca05346287868ea55a1affae0859a8
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

AKAP6 CASQ2 EDIL3 RGPD5

3.81e-04160954d783d29150033e9181c0e30870070268fed3fd85
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FRMD4A PDE3A EDIL3 HEPH

3.90e-041619541b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCellInfluenza_Severe-Neutrophil|Influenza_Severe / Disease group and Cell class

ANXA3 SLC26A4 PYGL SORL1

3.90e-0416195498c95b1b85d5427415af2ca8fb14849e97f6e8b5
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3A MTHFR CD46 EDIL3

4.00e-04162954c7114e24cb5525abb9780ca3d35dbcc4eabd4b64
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3A MTHFR CD46 EDIL3

4.00e-04162954f1851a173d3bcca2981d934161ec85d1cc0af5a2
ToppCellfacs-Heart-RA-3m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 BMP10 PDE4DIP NLRP3

4.00e-041629543a61eda548afa2a41bdf6293d1050103dc210e52
ToppCellfacs-Heart-RA-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 BMP10 PDE4DIP NLRP3

4.00e-04162954593939be9d38690c89c31d4c58e351de26cbf9ab
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3A MTHFR CD46 EDIL3

4.00e-041629545d902bb31e691aea9749617cc88303c2448f24b8
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AKAP6 SLC26A4 LTA4H ZNF598

4.09e-04163954360cd65decda24853124f33a174f5224d7f3ce23
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AKAP6 SLC26A4 LTA4H ZNF598

4.09e-04163954b59d9b4f7c9f4e5e2c7783a49a96729dae3a81e5
ToppCell367C-Myeloid-Dendritic-cDC_proliferating_2|367C / Donor, Lineage, Cell class and subclass (all cells)

CENPF SCN9A PROSER1 PLEKHD1

4.19e-041649540662cd9d21608efacc336e0a582859f3b9a4951d
ToppCelldroplet-Limb_Muscle-nan-3m-Myeloid-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRMD4A MUC13 NLRP3 AXIN2

4.38e-041669540a7992bc673fca546636563ec3fc17a4298ab6b1
Diseasevenous thromboembolism, von Willebrand factor measurement

PTPRJ STXBP5 TAB1 FCHO2

7.93e-0642894EFO_0004286, EFO_0004629
DiseaseParoxysmal atrial fibrillation

AKAP6 MYH6 REEP1 CASQ2 PHLDB2 SORL1

8.02e-06156896C0235480
Diseasefamilial atrial fibrillation

AKAP6 MYH6 REEP1 CASQ2 PHLDB2 SORL1

8.02e-06156896C3468561
DiseasePersistent atrial fibrillation

AKAP6 MYH6 REEP1 CASQ2 PHLDB2 SORL1

8.02e-06156896C2585653
DiseaseAtrial Fibrillation

AKAP6 MYH6 REEP1 CASQ2 PHLDB2 SORL1

9.27e-06160896C0004238
Diseasefactor VIII measurement, von Willebrand factor measurement

STXBP5 TAB1 FCHO2

7.36e-0527893EFO_0004629, EFO_0004630
DiseaseIschemic stroke, von Willebrand factor measurement

STXBP5 TAB1 FCHO2

1.02e-0430893EFO_0004629, HP_0002140
Diseasefactor VIII measurement, venous thromboembolism

PTPRJ STXBP5 FCHO2

1.48e-0434893EFO_0004286, EFO_0004630
Diseasefactor VIII measurement

STXBP5 TAB1 FCHO2

2.42e-0440893EFO_0004630
DiseaseDepressive disorder

SLC6A2 MTHFR LTA4H STIP1 MED12 GSK3A

2.47e-04289896C0011581
DiseaseRecurrent depression

SLC6A2 TOR1A

3.19e-049892C0221480
Diseasefibrinogen measurement, tissue plasminogen activator measurement

STXBP5 CHD9 NLRP3

3.43e-0445893EFO_0004623, EFO_0004791
Diseasecolorectal cancer (is_implicated_in)

BRIP1 PTPRJ GALNT12 AXIN2

5.02e-04121894DOID:9256 (is_implicated_in)
Diseasemyeloid white cell count

FAP PDE3A HSP90B2P GNPDA1 PTPRJ STXBP5 PSMD2 CD46 NLRP3 SORL1

5.24e-049378910EFO_0007988
DiseasePulmonary Thromboembolisms

MTHFR MERTK

5.82e-0412892C0524702
DiseasePulmonary Embolism

MTHFR MERTK

5.82e-0412892C0034065
Diseaseneutrophil count, basophil count

HSP90B2P GNPDA1 PTPRJ PSMD2 NLRP3

5.96e-04224895EFO_0004833, EFO_0005090
Diseasevon Willebrand factor measurement

STXBP5 TAB1 FCHO2

6.55e-0456893EFO_0004629
Diseasealcohol and nicotine codependence

RGPD2 RGPD1

6.87e-0413892EFO_0004776
Diseasecreatine kinase measurement

AKAP6 BRIP1 NEB

7.63e-0459893EFO_0004534
Diseasecreatinine measurement

ULK3 FAP BRIP1 PTPRJ CENPF DNAJC16 CHD9 PSMD2 NEB SORL1

8.31e-049958910EFO_0004518
Diseaseatrial fibrillation

AKAP6 MYH6 MTHFR CASQ2 PHLDB2 SORL1

9.17e-04371896EFO_0000275
Diseasealkaline phosphatase measurement

PTPRJ SLC26A4 PYGL ST6GAL1 TAB1 FCHO2 PLEKHD1 NLRP3 GABBR1 AXIN1

9.66e-0410158910EFO_0004533
Diseasehemorrhoid

FRMD4A BRIP1 MERTK PHLDB2

1.04e-03147894EFO_0009552
Diseasegranulocyte count

HSP90B2P PTPRJ PSMD2 ITLN2 NLRP3

1.05e-03254895EFO_0007987
Diseaseacute lymphoblastic leukemia

WDR19 PTPRJ PYGL

1.06e-0366893EFO_0000220
Diseasevenous thromboembolism, fibrinogen measurement

PTPRJ CHD9 NLRP3

1.11e-0367893EFO_0004286, EFO_0004623
DiseaseSLAM family member 7 measurement

ST6GAL1 ITLN2

1.19e-0317892EFO_0008287
DiseaseCongenital Myasthenic Syndromes, Postsynaptic

AK9 PREPL

1.19e-0317892C0751883
DiseaseColorectal Carcinoma

AKAP6 MTHFR LAMA1 VPS13A GALNT12 CD46 AXIN2 SORL1

1.28e-03702898C0009402
DiseaseMalignant tumor of colon

PTPRJ MTHFR CP AXIN2

1.39e-03159894C0007102
Diseasefactor VIII measurement, Ischemic stroke

STXBP5 FCHO2

1.49e-0319892EFO_0004630, HP_0002140
DiseaseN-glycan measurement

ST6GAL1 TAB1

2.00e-0322892EFO_0004999
DiseaseImmunologic Deficiency Syndromes

NBAS C8B

2.18e-0323892C0021051
DiseaseColorectal cancer

PTPRJ AXIN2

3.01e-0327892cv:C0346629
DiseaseGlycogen Storage Disease

PYGL FBP2

3.01e-0327892C0017919
DiseaseCOLORECTAL CANCER

PTPRJ AXIN2

3.01e-0327892114500
DiseaseNeoplasm of the large intestine

PTPRJ AXIN2

3.01e-0327892cv:C0009404
Diseaseindole-3-propionate measurement

SLC6A2 NBAS

3.01e-0327892EFO_0010501
Diseasehypertension, COVID-19

ULK3 PTPRJ

3.01e-0327892EFO_0000537, MONDO_0100096
Diseasethrombocytopenia (is_implicated_in)

BRIP1 MTHFR

3.01e-0327892DOID:1588 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
NVKCAYKKYLYGFEE

ARID4B

381

Q4LE39
KAYLEEEEYLGKKSY

ERICH6B

161

Q5W0A0
AYTLAKAYFDVKEYD

CDC23

86

Q9UJX2
TYKLYVEKYALAKAD

FCHO2

176

Q0JRZ9
AYYTVYKKSLGDDIS

ANXA3

131

P12429
FKKHYGYSLYSAIKS

ANXA3

291

P12429
FKEQLSKKGNYRYYF

AXIN2

791

Q9Y2T1
DYELKYCFVDKYKGT

RAVER1

81

Q8IY67
SMKGFYFAKLYYEAK

RANBP2

26

P49792
SMKGFYFAKLYYEAK

RGPD5

26

Q99666
SMKGFYFAKLYYEAK

RGPD8

26

O14715
KAVKAFLDYAYTGKT

KBTBD3

101

Q8NAB2
GFLKAYVEKFSYKSI

LTA4H

406

P09960
GEFYIGSKYKKVVYR

CP

771

P00450
DEYGSKKSDYIKLYV

HSP90B2P

56

Q58FF3
AFGELKDYYLFYLKS

MTHFR

396

P42898
YEDFKKGASDTYVTY

PTPRJ

871

Q12913
IGERVDYKCKKGYFY

CD46

56

P15529
KLIEYYKNGDLSFKY

GNPDA1

51

P46926
DFGLSKKIYSGDYYR

MERTK

741

Q12866
TFTGKLYIEFVKGYY

MLEC

186

Q14165
SYKKIGYYDSTKDDL

GABBR1

546

Q9UBS5
GYFKDKAFVNYLKYL

MED31

41

Q9Y3C7
KGKIYSLNEGYAKYF

FBP2

206

O00757
CDEFTKSYYKSKYGI

EFHC2

356

Q5JST6
KSYYKSKYGIENFTS

EFHC2

361

Q5JST6
YVFSKTYNVTDDKYG

PDE3A

801

Q14432
LYKLTAFAYKDYLSF

DNAJC16

286

Q9Y2G8
FSKKEEVFGYLAKYT

MED12

136

Q93074
DYEISAKARYFGYIK

NBAS

476

A2RRP1
YKLKAIEYVHGYFSS

PROSER1

21

Q86XN7
VYYDAIKYKGEKDGA

BRIP1

741

Q9BX63
AVGVKLKYCRYYAKD

PAN3

41

Q58A45
STRGFYFAKLYYEAK

RGPD3

26

A6NKT7
SYKGIFQYDYHDKVK

FRMD4A

236

Q9P2Q2
EYIKSYKIAYSNDGK

EDIL3

241

O43854
YADYKYFVSLFEDKT

HSPBAP1

126

Q96EW2
IDTEEFFVKYKNYSY

CHD9

711

Q3L8U1
RYFFYSSGEKKDELY

GSK3A

176

P49840
YLDKGVVTYKFKYEG

BMP10

401

O95393
SQYYSGSKYEDLKEK

CENPF

156

P49454
KKGSYRYYFKKVSDE

AXIN1

816

O15169
AVSKKYFEYLGSYDT

GALNT12

316

Q8IXK2
VVYDFGDAKKTASYY

ITLN2

221

Q8WWU7
KLIGFFKSEDSEYYK

CASQ2

166

O14958
KSTDYGKYEGLTKNY

EXOC1

396

Q9NV70
QRKKLYYDTDYGSKS

UTP3

131

Q9NQZ2
KYEFILKEYESYSDF

C8B

226

P07358
KEYDLAKKYVCTYLS

RGPD1

31

P0DJD0
LGFSEAKRKEYFFKY

NLRP3

371

Q96P20
AKRKEYFFKYFSDEA

NLRP3

376

Q96P20
KYREKIYYFSSAEAK

AK9

956

Q5TCS8
KYSKYKFTPAAEFYE

SLC6A2

201

P23975
STRGFYFAKLYYEAK

RGPD4

26

Q7Z3J3
YVSYDYGKSFKKISD

SORL1

136

Q92673
AAYAKKGDYQKAYED

STIP1

46

P31948
YKVKYGYTDIDLLSA

TAB1

246

Q15750
DFSYAGLKDKKAITY

PUS7L

331

Q9H0K6
LRGFYFAKLYYEAKE

RGPD2

26

P0DJD1
YEAKEYDLAKKYVCT

RGPD2

36

P0DJD1
YVTKYYGSYLKGSKL

STK26

81

Q9P289
KYLYSSEDYIKSGAL

PSMD2

431

Q13200
YYKKVADYIADTFEK

SEL1L2

241

Q5TEA6
MAYGGKLKYSVAFYS

LAMA1

1231

P25391
GTYKKTIYKEYKDDS

HEPH

71

Q9BQS7
EEDFRKYFYYLEGSK

SCN9A

296

Q15858
YVFAKKDSKYAYTGE

POLR2B

206

P30876
KGSYYDSFKLQTKEF

ST6GAL1

31

P15907
GLYYDKAASVYIRSK

WDR19

866

Q8NEZ3
TLYPAYYSYKAVKSK

REEP1

16

Q9H902
VYYSIGALAKAVYEK

MYH6

421

P13533
KKDLAIYYSYGDFLL

NOP2

271

P46087
YYADKHETKLKGVIY

PHLDB2

1176

Q86SQ0
KSKKADYRYTYDEAI

STXBP5

226

Q5T5C0
KYDYVLTGYTRDKSF

PDXK

76

O00764
TFYDYSYLQGSKLKL

AKAP6

1466

Q13023
YKEGTYVYKTQSEKY

CLRN1

171

P58418
SEKKSYFSYFFGEKS

NLRP9

301

Q7RTR0
YFSYFFGEKSKALKV

NLRP9

306

Q7RTR0
AISYYKIFSDKDGYK

FAP

361

Q12884
EDYAAYKESTYAKGK

UBTFL6

301

P0CB48
KFKSKEYDEYSTYSD

ZC3H6

131

P61129
GYKSVDEYKVHKGSY

ZNF724

116

A8MTY0
YKKAVYITGKEVFSF

VPS13A

1111

Q96RL7
DKGCKTVFTKLDYYY

TOR1A

316

O14656
EGYYYNSSTCKKGKV

MUC13

201

Q9H3R2
SVGKVYATKYDYTID

SLC26A4

366

O43511
YYSESEKKSFETNKY

PLEKHD1

61

A6NEE1
DEKKGTVYIYSYFHF

SERINC5

381

Q86VE9
KYYTYKFAEGKLFEE

PREPL

416

Q4J6C6
KKYDIYFADGKVYAL

ZNF598

96

Q86UK7
DKFYKSEDYGKDYPS

ZNF112

886

Q9UJU3
TGFSYYAATKTKYRK

ZBED5

646

Q49AG3
YTFEKSYEFKDFEKA

ZNF790

611

Q6PG37
ALDKKGYEAKEYYEA

PYGL

721

P06737
TYKDEGNDYFKEKDY

TTC4

81

O95801
GSGTYATVYKAYAKK

ULK3

21

Q6PHR2
YSYAAYSAKGTLKAE

NAALADL2

261

Q58DX5
YEALYGNSKKGLKAY

PDE4DIP

2016

Q5VU43
DREYKKGYEASKTKY

NEB

1611

P20929
SRDIASDYKYKKAYE

NEB

1811

P20929
DIASDYKYKEGYRKQ

NEB

3516

P20929