Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled glutamate receptor activity	GRM1 GRM2 GRM3 GRM4 GRM7	1.06e-10	9	79	5	GO:0098988
GeneOntologyMolecularFunction	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	GRM1 GRM2 GRM3 GRM4 GRM7	1.06e-10	9	79	5	GO:0001640
GeneOntologyMolecularFunction	glutamate receptor activity	GRM1 GRM2 GRM3 GRM4 GRM7	6.43e-08	27	79	5	GO:0008066
GeneOntologyMolecularFunction	group II metabotropic glutamate receptor activity	GRM2 GRM3	1.55e-05	2	79	2	GO:0001641
GeneOntologyMolecularFunction	serine binding	SHMT1 GRM7	4.62e-05	3	79	2	GO:0070905
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR2	9.23e-05	4	79	2	GO:0005219
GeneOntologyMolecularFunction	group III metabotropic glutamate receptor activity	GRM4 GRM7	9.23e-05	4	79	2	GO:0001642
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR2	2.29e-04	6	79	2	GO:0048763
GeneOntologyMolecularFunction	neuregulin binding	ERBB3 ITGB4	2.29e-04	6	79	2	GO:0038132
GeneOntologyMolecularFunction	calmodulin binding	PDE1A MYH13 GRM4 GRM7 RYR1 RYR2	3.02e-04	230	79	6	GO:0005516
GeneOntologyMolecularFunction	calcium channel regulator activity	GRM2 GRM3 GRM7	1.28e-03	54	79	3	GO:0005246
GeneOntologyMolecularFunction	arylsulfatase activity	ARSA ARSB	1.36e-03	14	79	2	GO:0004065
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	GRM1 GRM2 GRM3 GRM4 GRM7	8.45e-11	9	78	5	GO:0007196
GeneOntologyBiologicalProcess	G protein-coupled glutamate receptor signaling pathway	GRM1 GRM2 GRM3 GRM4 GRM7	2.87e-09	16	78	5	GO:0007216
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	FLNA GRM1 GRM2 GRM3 GRM4 GRM7	8.89e-07	86	78	6	GO:0007193
GeneOntologyBiologicalProcess	glutamate receptor signaling pathway	GRM1 GRM2 GRM3 GRM4 GRM7	2.90e-06	59	78	5	GO:0007215
GeneOntologyBiologicalProcess	regulation of synaptic transmission, glutamatergic	GRM1 GRM2 GRM3 GRM4 GRM7	2.58e-05	92	78	5	GO:0051966
GeneOntologyBiologicalProcess	response to pH	ARSA ARSB ASIC3 CTSS	3.52e-05	49	78	4	GO:0009268
GeneOntologyBiologicalProcess	maintenance of Golgi location	TBCCD1 UVRAG	4.23e-05	3	78	2	GO:0051684
GeneOntologyBiologicalProcess	neuron development	MYT1L TANC2 AGBL4 FLNA LIMK1 EFNA2 ARSB GLI3 FES SPAG9 TSHR EIF2AK4 WLS GRM7 SPAG6 CYFIP2	9.74e-05	1463	78	16	GO:0048666
GeneOntologyBiologicalProcess	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	FLNA TSHR GRM1 GRM2 GRM3 GRM4 GRM7	1.04e-04	286	78	7	GO:0007188
GeneOntologyBiologicalProcess	cGMP catabolic process	PDE1A PDE9A	1.40e-04	5	78	2	GO:0046069
GeneOntologyBiologicalProcess	response to methylmercury	ARSA ARSB	1.40e-04	5	78	2	GO:0051597
GeneOntologyBiologicalProcess	synaptic transmission, glutamatergic	GRM1 GRM2 GRM3 GRM4 GRM7	1.44e-04	132	78	5	GO:0035249
GeneOntologyBiologicalProcess	neuron projection development	TANC2 FLNA LIMK1 EFNA2 ARSB GLI3 FES SPAG9 TSHR EIF2AK4 WLS GRM7 SPAG6 CYFIP2	2.96e-04	1285	78	14	GO:0031175
Domain	GPCR_3_mtglu_rcpt	GRM1 GRM2 GRM3 GRM4 GRM7	6.18e-11	8	78	5	IPR000162
Domain	NCD3G	GRM1 GRM2 GRM3 GRM4 GRM7	1.40e-09	13	78	5	PF07562
Domain	GPCR_3_9-Cys_dom	GRM1 GRM2 GRM3 GRM4 GRM7	1.40e-09	13	78	5	IPR011500
Domain	GPCR_3_CS	GRM1 GRM2 GRM3 GRM4 GRM7	2.17e-09	14	78	5	IPR017979
Domain	GPCR_3	GRM1 GRM2 GRM3 GRM4 GRM7	2.15e-08	21	78	5	IPR000337
Domain	7tm_3	GRM1 GRM2 GRM3 GRM4 GRM7	2.78e-08	22	78	5	PF00003
Domain	G_PROTEIN_RECEP_F3_2	GRM1 GRM2 GRM3 GRM4 GRM7	2.78e-08	22	78	5	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM1 GRM2 GRM3 GRM4 GRM7	2.78e-08	22	78	5	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM1 GRM2 GRM3 GRM4 GRM7	2.78e-08	22	78	5	PS00979
Domain	G_PROTEIN_RECEP_F3_4	GRM1 GRM2 GRM3 GRM4 GRM7	2.78e-08	22	78	5	PS50259
Domain	GPCR_3_C	GRM1 GRM2 GRM3 GRM4 GRM7	2.78e-08	22	78	5	IPR017978
Domain	ANF_lig-bd_rcpt	GRM1 GRM2 GRM3 GRM4 GRM7	4.38e-07	37	78	5	IPR001828
Domain	ANF_receptor	GRM1 GRM2 GRM3 GRM4 GRM7	4.38e-07	37	78	5	PF01094
Domain	Peripla_BP_I	GRM1 GRM2 GRM3 GRM4 GRM7	5.75e-07	39	78	5	IPR028082
Domain	Ryanrecept_TM4-6	RYR1 RYR2	5.15e-05	3	78	2	IPR009460
Domain	RyR	RYR1 RYR2	5.15e-05	3	78	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR2	5.15e-05	3	78	2	IPR003032
Domain	RR_TM4-6	RYR1 RYR2	5.15e-05	3	78	2	PF06459
Domain	Ryan_recept	RYR1 RYR2	5.15e-05	3	78	2	IPR013333
Domain	RIH_assoc	RYR1 RYR2	2.55e-04	6	78	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR2	2.55e-04	6	78	2	IPR013662
Domain	RIH_dom	RYR1 RYR2	2.55e-04	6	78	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR2	2.55e-04	6	78	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR2	2.55e-04	6	78	2	IPR015925
Domain	-	RYR1 RYR2	2.55e-04	6	78	2	1.25.10.30
Domain	RYDR_ITPR	RYR1 RYR2	2.55e-04	6	78	2	PF01365
Domain	Ins145_P3_rec	RYR1 RYR2	2.55e-04	6	78	2	PF08709
Domain	MIR	RYR1 RYR2	7.58e-04	10	78	2	PS50919
Domain	MIR	RYR1 RYR2	7.58e-04	10	78	2	PF02815
Domain	MIR	RYR1 RYR2	7.58e-04	10	78	2	SM00472
Domain	MIR_motif	RYR1 RYR2	7.58e-04	10	78	2	IPR016093
Domain	TPR_8	TANC2 IFIT1B TTC13	1.41e-03	53	78	3	PF13181
Domain	Sulfatase_CS	ARSA ARSB	1.99e-03	16	78	2	IPR024607
Domain	Pkinase_Tyr	LIMK1 ERBB3 LIMK2 FES	2.09e-03	129	78	4	PF07714
Domain	SULFATASE_1	ARSA ARSB	2.25e-03	17	78	2	PS00523
Domain	SULFATASE_2	ARSA ARSB	2.25e-03	17	78	2	PS00149
Domain	Sulfatase	ARSA ARSB	2.52e-03	18	78	2	PF00884
Domain	Sulfatase_N	ARSA ARSB	2.52e-03	18	78	2	IPR000917
Domain	Ser-Thr/Tyr_kinase_cat_dom	LIMK1 ERBB3 LIMK2 FES	2.67e-03	138	78	4	IPR001245
Domain	PDEase	PDE1A PDE9A	2.81e-03	19	78	2	IPR023088
Domain	PROTEIN_KINASE_ATP	LIMK1 ERBB3 LIMK2 MYLK4 FES EIF2AK4 MAP3K3	3.04e-03	459	78	7	PS00107
Domain	PDEase_I	PDE1A PDE9A	3.43e-03	21	78	2	PF00233
Domain	PDEASE_I	PDE1A PDE9A	3.43e-03	21	78	2	PS00126
Domain	PDEase_CS	PDE1A PDE9A	3.43e-03	21	78	2	IPR023174
Domain	-	PDE1A PDE9A	3.77e-03	22	78	2	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE1A PDE9A	4.12e-03	23	78	2	IPR002073
Domain	Prot_kinase_dom	LIMK1 ERBB3 LIMK2 MYLK4 FES EIF2AK4 MAP3K3	4.31e-03	489	78	7	IPR000719
Domain	HDc	PDE1A PDE9A	4.48e-03	24	78	2	SM00471
Domain	HD/PDEase_dom	PDE1A PDE9A	4.48e-03	24	78	2	IPR003607
Domain	PROTEIN_KINASE_DOM	LIMK1 ERBB3 LIMK2 MYLK4 FES EIF2AK4 MAP3K3	4.50e-03	493	78	7	PS50011
Domain	TPR_REGION	TANC2 DNAH10 IFIT1B TTC13	5.04e-03	165	78	4	PS50293
Domain	TPR	TANC2 DNAH10 IFIT1B TTC13	5.04e-03	165	78	4	PS50005
Domain	SPRY	RYR1 RYR2 SPRYD7	5.77e-03	87	78	3	SM00449
Domain	SPRY	RYR1 RYR2 SPRYD7	7.15e-03	94	78	3	PF00622
Domain	SPRY_dom	RYR1 RYR2 SPRYD7	7.15e-03	94	78	3	IPR003877
Domain	B30.2/SPRY	RYR1 RYR2 SPRYD7	7.36e-03	95	78	3	IPR001870
Domain	B302_SPRY	RYR1 RYR2 SPRYD7	7.36e-03	95	78	3	PS50188
Domain	Alkaline_phosphatase_core	ARSA ARSB	7.40e-03	31	78	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ARSA ARSB	7.40e-03	31	78	2	IPR017849
Domain	-	ARSA ARSB	7.40e-03	31	78	2	3.40.720.10
Domain	Kinase-like_dom	LIMK1 ERBB3 LIMK2 MYLK4 FES EIF2AK4 MAP3K3	7.46e-03	542	78	7	IPR011009
Pathway	WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE	GRM1 GRM2 GRM3 GRM4 GRM7	4.05e-09	15	62	5	M39442
Pathway	WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE	GRM1 GRM2 GRM3 GRM4 GRM7	4.05e-09	15	62	5	MM15845
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	GRM1 GRM2 GRM3 GRM4 GRM7	5.46e-07	37	62	5	MM15067
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	GRM1 GRM2 GRM3 GRM4 GRM7	7.17e-07	39	62	5	M793
Pathway	WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING	PDHA1 SHMT1 GRM1 GRM2 GRM4 GRM7	3.35e-05	140	62	6	M42572
Pathway	WP_GPCRS_NONODORANT	FZD6 TSHR GRM1 GRM2 GRM3 GRM4 GRM7	1.60e-04	266	62	7	MM15843
Pubmed	Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.	GRM1 GRM2 GRM3 GRM4 GRM7	1.11e-12	7	79	5	9920659
Pubmed	Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.	GRM1 GRM2 GRM3 GRM4 GRM7	1.33e-11	10	79	5	9069281
Pubmed	Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q.	GRM1 GRM2 GRM3 GRM4	3.68e-10	6	79	4	8824806
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRM1 GRM2 GRM3 GRM4 GRM7	2.18e-09	24	79	5	35746896
Pubmed	The repertoire of olfactory C family G protein-coupled receptors in zebrafish: candidate chemosensory receptors for amino acids.	GRM1 GRM3 GRM4 GRM7	5.12e-09	10	79	4	17156446
Pubmed	Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.	GRM1 GRM2 GRM3	1.13e-08	3	79	3	34620856
Pubmed	Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system.	GRM1 GRM2 GRM3	4.50e-08	4	79	3	29079293
Pubmed	Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.	GRM1 GRM2 GRM3 GRM4 GRM7	6.05e-08	45	79	5	25979088
Pubmed	Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.	DNAH10 GLI3 ETV6 GRM3 RYR2 CYFIP2 MX1	3.70e-07	199	79	7	23382691
Pubmed	Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins.	GRM1 GRM2 GRM3	6.27e-07	8	79	3	11850456
Pubmed	Filamin-A regulates actin-dependent clustering of HIV receptors.	FLNA LIMK1 LIMK2	6.27e-07	8	79	3	17572668
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	GRM1 GRM2 GRM3 GRM4 GRM7	1.19e-06	81	79	5	22723691
Pubmed	The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.	GRM2 GRM3 GRM7	2.45e-06	12	79	3	11891216
Pubmed	Selective silencing of individual dendritic branches by an mGlu2-activated potassium conductance in dentate gyrus granule cells.	GRM2 GRM3	5.09e-06	2	79	2	23616537
Pubmed	The small GTPase RhoA regulates the LIMK1/2-cofilin pathway to modulate cytoskeletal dynamics in oocyte meiosis.	LIMK1 LIMK2	5.09e-06	2	79	2	29319181
Pubmed	Group II metabotropic glutamate receptor blockade promotes stress resilience in mice.	GRM2 GRM3	5.09e-06	2	79	2	30939596
Pubmed	Association between KIR gene polymorphisms and type 1 diabetes mellitus (T1DM) susceptibility: A PRISMA-compliant meta-analysis.	KIR2DL1 KIR2DS1	5.09e-06	2	79	2	29384924
Pubmed	The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection.	GRM2 GRM3	5.09e-06	2	79	2	17670976
Pubmed	The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex.	GRM2 GRM3	5.09e-06	2	79	2	32525061
Pubmed	Different activity regulation and subcellular localization of LIMK1 and LIMK2 during cell cycle transition.	LIMK1 LIMK2	5.09e-06	2	79	2	16455074
Pubmed	Expression and subcellular distribution of glutamate receptor subunits 2/3 in the developing cerebellar cortex.	GRM2 GRM3	5.09e-06	2	79	2	8838577
Pubmed	Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors.	KIR2DL1 KIR2DS1	5.09e-06	2	79	2	16141329
Pubmed	Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.	GRM2 GRM3	5.09e-06	2	79	2	34330748
Pubmed	Neutrophil-derived glutamate regulates vascular endothelial barrier function.	GRM1 GRM4	5.09e-06	2	79	2	11847215
Pubmed	Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.	GRM2 GRM3	5.09e-06	2	79	2	25434487
Pubmed	Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.	RYR1 RYR2	5.09e-06	2	79	2	17259277
Pubmed	NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.	GRM2 GRM3	5.09e-06	2	79	2	28285415
Pubmed	Cloning and biochemical characterization of LIMK-2, a protein kinase containing two LIM domains.	LIMK1 LIMK2	5.09e-06	2	79	2	9089416
Pubmed	mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.	GRM2 GRM3	5.09e-06	2	79	2	34090896
Pubmed	Ryanodine receptor oligomeric interaction: identification of a putative binding region.	RYR1 RYR2	5.09e-06	2	79	2	14722100
Pubmed	Structural and functional interactions within ryanodine receptor.	RYR1 RYR2	5.09e-06	2	79	2	26009179
Pubmed	The sulfatase gene family: cross-species PCR cloning using the MOPAC technique.	ARSA ARSB	5.09e-06	2	79	2	1572648
Pubmed	Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.	RYR1 RYR2	5.09e-06	2	79	2	32899693
Pubmed	Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice.	GRM2 GRM3	5.09e-06	2	79	2	22089319
Pubmed	A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency.	ARSA ARSB	5.09e-06	2	79	2	7628016
Pubmed	Regulation of cocaine-induced reinstatement by group II metabotropic glutamate receptors in the ventral tegmental area.	GRM2 GRM3	5.09e-06	2	79	2	21881873
Pubmed	The Size of Activating and Inhibitory Killer Ig-like Receptor Nanoclusters Is Controlled by the Transmembrane Sequence and Affects Signaling.	KIR2DL1 KIR2DS1	5.09e-06	2	79	2	27210755
Pubmed	Fractionation of spatial memory in GRM2/3 (mGlu2/mGlu3) double knockout mice reveals a role for group II metabotropic glutamate receptors at the interface between arousal and cognition.	GRM2 GRM3	5.09e-06	2	79	2	21832989
Pubmed	KIR2DS1 and KIR2DL1-C245 Dominantly Repress NK Cell Degranulation Triggered by Monoclonal or Bispecific Antibodies, whereas Education by Uptuning Inhibitory Killer Ig-related Receptors Exerts No Advantage in Ab-dependent Cellular Cytotoxicity.	KIR2DL1 KIR2DS1	5.09e-06	2	79	2	38240527
Pubmed	LIMK1 and LIMK2 are important for metastatic behavior and tumor cell-induced angiogenesis of pancreatic cancer cells.	LIMK1 LIMK2	5.09e-06	2	79	2	20047470
Pubmed	The role of group II metabotropic glutamate receptors in cognition and anxiety: comparative studies in GRM2(-/-), GRM3(-/-) and GRM2/3(-/-) knockout mice.	GRM2 GRM3	5.09e-06	2	79	2	25158312
Pubmed	Involvement of LIMK1/2 in actin assembly during mouse embryo development.	LIMK1 LIMK2	5.09e-06	2	79	2	29943641
Pubmed	Transient inhibition of LIMKs significantly attenuated central sensitization and delayed the development of chronic pain.	LIMK1 LIMK2	5.09e-06	2	79	2	28669900
Pubmed	Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.	RYR1 RYR2	5.09e-06	2	79	2	15033925
Pubmed	Altered hippocampal expression of glutamate receptors and transporters in GRM2 and GRM3 knockout mice.	GRM2 GRM3	5.09e-06	2	79	2	18720515
Pubmed	The C terminus of the metabotropic glutamate receptor subtypes 2 and 7 specifies the receptor signaling pathways.	GRM2 GRM7	5.09e-06	2	79	2	11584003
Pubmed	Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus.	GRM2 GRM3	5.09e-06	2	79	2	15246118
Pubmed	Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia.	GRM2 GRM3	5.09e-06	2	79	2	18853337
Pubmed	Hippocampal mossy fiber long-term depression in Grm2/3 double knockout mice.	GRM2 GRM3	5.09e-06	2	79	2	21360593
Pubmed	Self-association of LIM-kinase 1 mediated by the interaction between an N-terminal LIM domain and a C-terminal kinase domain.	LIMK1 LIMK2	5.09e-06	2	79	2	8980133
Pubmed	Expression of metabotropic glutamate receptor mRNAs in the human spinal cord: implications for selective vulnerability of spinal motor neurons in amyotrophic lateral sclerosis.	GRM1 GRM3	5.09e-06	2	79	2	11535235
Pubmed	Developmental expression of mGlu2 and mGlu3 in the mouse brain.	GRM2 GRM3	5.09e-06	2	79	2	27818290
Pubmed	LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition does not reduce metastasis in mice.	LIMK1 LIMK2	5.09e-06	2	79	2	23239465
Pubmed	Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology.	AHR EIF2AK4	5.09e-06	2	79	2	31653831
Pubmed	Activation of metabotropic glutamate receptor type 2/3 supports the involvement of the hippocampal mossy fiber pathway on contextual fear memory consolidation.	GRM2 GRM3	5.09e-06	2	79	2	19638469
Pubmed	Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.	GRM2 GRM3	5.09e-06	2	79	2	21628565
Pubmed	Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice.	GRM2 GRM3	5.09e-06	2	79	2	24053122
Pubmed	Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis.	GRM1 GRM2	5.09e-06	2	79	2	15330338
Pubmed	The Diagnostic and Prognostic Value of LIMK1/2: A Pan-Cancer Analysis.	LIMK1 LIMK2	5.09e-06	2	79	2	34686503
Pubmed	Adaptive Changes in Group 2 Metabotropic Glutamate Receptors Underlie the Deficit in Recognition Memory Induced by Methamphetamine in Mice.	GRM2 GRM3	5.09e-06	2	79	2	38969501
Pubmed	Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.	GRM2 GRM3	5.09e-06	2	79	2	25583490
Pubmed	Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia.	GRM4 GRM7	5.09e-06	2	79	2	19351574
Pubmed	Phosphorylated LIM kinases colocalize with gamma-tubulin in centrosomes during early stages of mitosis.	LIMK1 LIMK2	5.09e-06	2	79	2	18000399
Pubmed	The mGluR2/3 agonist LY379268 induced anti-reinstatement effects in rats exhibiting addiction-like behavior.	GRM2 GRM3	5.09e-06	2	79	2	23624743
Pubmed	Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light.	GRM2 GRM3	5.09e-06	2	79	2	25950516
Pubmed	Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population.	GRM2 GRM3	5.09e-06	2	79	2	19386277
Pubmed	The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells.	GRM2 GRM3	5.09e-06	2	79	2	7965099
Pubmed	Otitis media in sperm-associated antigen 6 (Spag6)-deficient mice.	FZD6 SPAG6	5.09e-06	2	79	2	25393619
Pubmed	Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: the metabotropic pathway.	GRM2 GRM3	5.09e-06	2	79	2	24080311
Pubmed	Elevated LIM kinase 1 in nonmetastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation.	LIMK1 LIMK2	5.09e-06	2	79	2	25344584
Pubmed	Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion.	LIMK1 LIMK2	5.09e-06	2	79	2	31641031
Pubmed	Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.	RYR1 RYR2	5.09e-06	2	79	2	30542613
Pubmed	Activation of both Group I and Group II metabotropic glutamatergic receptors suppress retinogeniculate transmission.	GRM1 GRM2	5.09e-06	2	79	2	23558090
Pubmed	Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.	RYR1 RYR2	5.09e-06	2	79	2	15280431
Pubmed	Expression of the ryanodine receptor isoforms in immune cells.	RYR1 RYR2	5.09e-06	2	79	2	11673493
Pubmed	Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4.	GRM2 GRM4	5.09e-06	2	79	2	34135510
Pubmed	Structures of human mGlu2 and mGlu7 homo- and heterodimers.	GRM2 GRM7	5.09e-06	2	79	2	34135509
Pubmed	B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.	RYR1 RYR2	5.09e-06	2	79	2	11673462
Pubmed	Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.	GRM1 GRM4	5.09e-06	2	79	2	17446080
Pubmed	Investigation of killer cell immunoglobulin-like receptor gene diversity, KIR2DL1 and KIR2DS1.	KIR2DL1 KIR2DS1	5.09e-06	2	79	2	18643963
Pubmed	Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.	GRM2 GRM4	5.09e-06	2	79	2	24381270
Pubmed	Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors.	GRM2 GRM3	5.09e-06	2	79	2	27911756
Pubmed	Reduction of group II metabotropic glutamate receptors during development of benzodiazepine dependence.	GRM2 GRM3	5.09e-06	2	79	2	23392308
Pubmed	Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice.	GRM2 GRM3	5.09e-06	2	79	2	20970439
Pubmed	Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.	RYR1 RYR2	5.09e-06	2	79	2	25370123
Pubmed	LIM kinases: function, regulation and association with human disease.	LIMK1 LIMK2	5.09e-06	2	79	2	17294230
Pubmed	Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.	GRM2 GRM3	5.09e-06	2	79	2	34217776
Pubmed	Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.	RYR1 RYR2	5.09e-06	2	79	2	18618700
Pubmed	(S)-4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice.	GRM1 GRM2	5.09e-06	2	79	2	8189254
Pubmed	Memantine-induced brain activation as a model for the rapid screening of potential novel antipsychotic compounds: exemplified by activity of an mGlu2/3 receptor agonist.	GRM2 GRM3	5.09e-06	2	79	2	21057775
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	MYT1L TBCCD1 FLNA THOP1 SETD5 STXBP4 SHMT1 EIF2AK4 ANKRD50 WLS ITGB4 MAP3K3	5.92e-06	1084	79	12	11544199
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TANC2 FLNA FAM20C EFNA2 SETD5 RNPEPL1 HELZ2 TBC1D25 ITGB4 UVRAG TRAPPC9 RYR1	7.19e-06	1105	79	12	35748872
Pubmed	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	GRM1 GRM2 GRM3 GRM4 GRM7	7.61e-06	118	79	5	19156168
Pubmed	Otic mesenchyme cells regulate spiral ganglion axon fasciculation through a Pou3f4/EphA4 signaling pathway.	EFNA2 GRM2 GRM3	8.98e-06	18	79	3	22243746
Pubmed	Prognostic role of KIR genes and HLA-C after hematopoietic stem cell transplantation in a patient cohort with acute myeloid leukemia from a consanguineous community.	KIR2DL1 KIR2DS1	1.53e-05	3	79	2	29549293
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR2	1.53e-05	3	79	2	18403125
Pubmed	GPER stabilizes F-actin cytoskeleton and activates TAZ via PLCβ-PKC and Rho/ROCK-LIMK-Cofilin pathway.	LIMK1 LIMK2	1.53e-05	3	79	2	31277940
Pubmed	LIMK Regulates Tumor-Cell Invasion and Matrix Degradation Through Tyrosine Phosphorylation of MT1-MMP.	LIMK1 LIMK2	1.53e-05	3	79	2	27116935
Pubmed	Role of β4 integrin in HER-3-negative, K-RAS wild-type metastatic colorectal tumors receiving cetuximab.	ERBB3 ITGB4	1.53e-05	3	79	2	23617461
Pubmed	AHR/TET2/NT5E axis downregulation is associated with the risk of systemic lupus erythematosus and its progression.	NT5E AHR	1.53e-05	3	79	2	36314527
Interaction	GRM4 interactions	FLNA GRM3 GRM4 GRM7	7.07e-08	11	79	4	int:GRM4
Interaction	CALR interactions	FAM20C ARSA PTPRN PDHA1 MYLK4 TSHR GRM2 CTSS CYFIP2	3.45e-05	414	79	9	int:CALR
Interaction	GXYLT1 interactions	SEL1L FZD6 EFNA2 ITGB4 CTSS	4.16e-05	98	79	5	int:GXYLT1
Interaction	GRM7 interactions	FLNA GRM4 GRM7	5.37e-05	19	79	3	int:GRM7
Interaction	TAMALIN interactions	GRM1 GRM2 GRM3	5.37e-05	19	79	3	int:TAMALIN
Cytoband	14q31	SEL1L TSHR	1.04e-04	9	79	2	14q31
Cytoband	17q23.3	TANC2 MAP3K3	1.23e-03	30	79	2	17q23.3
Cytoband	17q21.33	LUC7L3 SPAG9	2.30e-03	41	79	2	17q21.33
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM1 GRM2 GRM3 GRM4 GRM7	8.99e-12	8	52	5	281
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR2	2.43e-05	3	52	2	287
GeneFamily	Sulfatases	ARSA ARSB	1.21e-03	18	52	2	410
GeneFamily	CD molecules\|Killer cell immunoglobulin like receptors	KIR2DL1 KIR2DS1	1.21e-03	18	52	2	620
GeneFamily	Phosphodiesterases	PDE1A PDE9A	2.15e-03	24	52	2	681
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TANC2 IFIT1B TTC13	4.42e-03	115	52	3	769
GeneFamily	PDZ domain containing	LIMK1 LIMK2 STXBP4	9.53e-03	152	52	3	1220
GeneFamily	LIM domain containing	LIMK1 LIMK2	1.25e-02	59	52	2	1218
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	GRM1 GRM7 RYR1	1.52e-02	181	52	3	694
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF142 ZNF532 ZNF658 GLI3 TRPS1 ZNF710	1.66e-02	718	52	6	28
Coexpression	WHITESIDE_CISPLATIN_RESISTANCE_UP	ERBB3 ITGB4 MX1	4.11e-06	11	78	3	M1499
Coexpression	GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_UP	LIMK2 HELZ2 ETV6 ITGB4 CTSS MX1	2.90e-05	199	78	6	M5357
Coexpression	GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP	IFIT1B HELZ2 AHR SPAG9 ITGB4 CYFIP2	2.90e-05	199	78	6	M9745
Coexpression	GSE28726_NAIVE_VS_ACTIVATED_CD4_TCELL_UP	LIMK2 IFFO1 ASIC3 CYFIP2 MAP3K3 MX1	2.98e-05	200	78	6	M8320
Coexpression	GSE3982_EOSINOPHIL_VS_EFF_MEMORY_CD4_TCELL_UP	LIMK2 ACOT9 ETV6 ASIC3 CTSS MAP3K3	2.98e-05	200	78	6	M5416
Coexpression	GSE21380_NON_TFH_VS_TFH_CD4_TCELL_DN	FZD6 FLNA IFIT1B HELZ2 EIF2AK4 ANKRD50	2.98e-05	200	78	6	M7502
Coexpression	LAKE_ADULT_KIDNEY_C13_THICK_ASCENDING_LIMB	AGBL4 PDE1A KIAA1217 STXBP4 CYFIP2	4.55e-05	131	78	5	M39232
Coexpression	KRAS.KIDNEY_UP.V1_DN	FOLR2 GRM2 GRM4 RYR2 MX1	5.25e-05	135	78	5	M2889
Coexpression	LAKE_ADULT_KIDNEY_C16_COLLECTING_SYSTEM_PRINCIPAL_CELLS_CORTEX	TANC2 AGBL4 PDE1A TRPS1 TRAPPC9	6.46e-05	141	78	5	M39235
Coexpression	KUNINGER_IGF1_VS_PDGFB_TARGETS_UP	ERBB3 IFFO1 MYLK4 RYR1	1.06e-04	82	78	4	M9065
Coexpression	KUNINGER_IGF1_VS_PDGFB_TARGETS_UP	ERBB3 IFFO1 MYLK4 RYR1	1.06e-04	82	78	4	MM1188
ToppCell	facs-GAT-Fat-18m-Myeloid-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FES AHR ETV6 CTSS RYR1 ZNF710	5.28e-07	169	78	6	7a7416fcbffcf57d19b477d9da091e04e3499524
ToppCell	facs-GAT-Fat-18m-Myeloid\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FES AHR ETV6 CTSS RYR1 ZNF710	5.28e-07	169	78	6	0e1a99cd77edcf32bcb513abd247b2b27409ac63
ToppCell	facs-GAT-Fat-18m-Myeloid-myeloid_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FES AHR ETV6 CTSS RYR1 ZNF710	5.28e-07	169	78	6	9bbad31ef03078f5aa456f2e1b17b49c91545ff0
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	AGBL4 PDE1A TCAIM STXBP4 GRM1 CYFIP2	8.67e-07	184	78	6	e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A STXBP4 GRM1 WLS GRM7 CYFIP2	9.83e-07	188	78	6	3cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCell	Control-Control-Myeloid-cDC\|Control / Disease, condition lineage and cell class	FES AHR ETV6 EIF2AK4 UVRAG RYR1	1.41e-06	200	78	6	1375d199320feb85ba06e74b10df6521e790addf
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA DNAH10 ZNF532 MX1 ZNF710	8.34e-06	157	78	5	ec433d2fe827abdb647be4176c231b7052482b6f
ToppCell	facs-Brain_Myeloid-Cerebellum-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA TRPS1 AHR RYR1 CYFIP2	9.15e-06	160	78	5	1f7acdc8b08152d5817fc53bbf47b4a22d9c91b5
ToppCell	facs-Lung-3m-Hematologic-myeloid-non-classical_monocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNA ETV6 CTSS RYR1 CYFIP2	1.00e-05	163	78	5	bbbc3f0ce2616d07136f69ce682ba1d3790711d9
ToppCell	facs-Lung-3m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNA ETV6 CTSS RYR1 CYFIP2	1.03e-05	164	78	5	11dfd84f5fb90de330858e1e852848832734e004
ToppCell	LV-16._Neuronal\|World / Chamber and Cluster_Paper	ERBB3 PDE9A KIAA1217 AHR ITGB4	1.06e-05	165	78	5	6ed52cb756d21addf46c7f6c457458b01339fe04
ToppCell	facs-MAT-Fat-18m-Myeloid-macrophage\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FES AHR ETV6 CTSS RYR1	1.13e-05	167	78	5	c2952d8ba763374c5678b92825c8956fc3e3ecd2
ToppCell	LA-16._Neuronal\|World / Chamber and Cluster_Paper	ERBB3 PDE9A KIAA1217 AHR ITGB4	1.16e-05	168	78	5	2fd1fd2a16ac1c5eb028f93cc3a2477c7747693e
ToppCell	LA-16._Neuronal\|LA / Chamber and Cluster_Paper	ERBB3 PDE9A KIAA1217 AHR ITGB4	1.16e-05	168	78	5	c55bbfbde8bb954f1cb9af82007bdd1f8070fee3
ToppCell	LV-16._Neuronal\|LV / Chamber and Cluster_Paper	ERBB3 PDE9A KIAA1217 AHR ITGB4	1.19e-05	169	78	5	a8fc8ab0f0757e939e213efb61c03cfe390bf7d2
ToppCell	facs-BAT-Fat-18m-Myeloid-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA TRPS1 FES ETV6 CTSS	1.30e-05	172	78	5	36fe66a8c0aecee7a19269be23210c0ed7abb155
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A PDE9A STXBP4 GRM1 CYFIP2	1.41e-05	175	78	5	e5467dacf81f1f913b1719931cf1a7331434a7e7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A PDE9A STXBP4 GRM1 CYFIP2	1.53e-05	178	78	5	4df6218b20c2f076c22346d23260964cc0d73e65
ToppCell	RA-16._Neuronal\|RA / Chamber and Cluster_Paper	ERBB3 PDE9A KIAA1217 AHR ITGB4	1.62e-05	180	78	5	5842febfdabac61ce970254fb0ef17a628f1b8c0
ToppCell	RA-16._Neuronal\|World / Chamber and Cluster_Paper	ERBB3 PDE9A KIAA1217 AHR ITGB4	1.66e-05	181	78	5	7d22a43f887e0747f0cb87ba364ff27905ee6eec
ToppCell	(05)_Ciliated-(1)_24hpi\|(05)_Ciliated / shred by cell type and Timepoint	BNIP5 FAM20C SHMT1 TBC1D25	1.74e-05	88	78	4	76959e7e3f6fae07c9881a29c28ba847be406694
ToppCell	Basal\|World / shred by cell class for mouse tongue	KLHL24 KIAA1217 SHMT1 GRM4 ITGB4	1.75e-05	183	78	5	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D175\|Adult / Lineage, Cell type, age group and donor	FAM20C ARSB FOLR2 TRPS1 RYR1	1.84e-05	185	78	5	ab5704b96f1d368911308797d10c7c52766ab134
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A PDE9A STXBP4 WLS CYFIP2	1.89e-05	186	78	5	1850583d23903d08226aeb0edb3e07b0994330e4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A PDE9A STXBP4 WLS CYFIP2	1.89e-05	186	78	5	4dafc215c42e7949f932a3627359c107943b5d6b
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYT1L PDE1A PTPRN RYR2 CYFIP2	1.94e-05	187	78	5	e04a84989d624378141042768383b9c846901f2d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYT1L PDE1A PTPRN RYR2 CYFIP2	1.94e-05	187	78	5	24cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYT1L PDE1A PTPRN RYR2 CYFIP2	1.94e-05	187	78	5	2f153b203fe79f206319603cf94d3a03ab49a05d
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRN MYLK4 GRM1 RYR2 CYFIP2	1.99e-05	188	78	5	4db566f3f708e66730aa9e16f4d73d91dc534177
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A TCAIM STXBP4 GRM1 CYFIP2	1.99e-05	188	78	5	2ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AGBL4 PDE1A GRM1 GRM7 RYR2	1.99e-05	188	78	5	50c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRN MYLK4 GRM1 RYR2 CYFIP2	1.99e-05	188	78	5	6704b92991ad8c0a910e9f36cd33d00bd26dcb8f
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	MYT1L GRM1 GRM4 GRM7 RYR2	2.10e-05	190	78	5	6e92c78799f34b31d098854503c796edb0dc7f80
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FES AHR EIF2AK4 UVRAG RYR1	2.15e-05	191	78	5	6cda82a994f4b205cf54590c979d7c9f3be2b4c8
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FES AHR EIF2AK4 UVRAG RYR1	2.15e-05	191	78	5	4257f02856f3510981e9f84d465d91448d6126e2
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYT1L PTPRN GRM1 RYR2 CYFIP2	2.26e-05	193	78	5	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)\|Adult / Lineage, Cell type, age group and donor	FOLR2 TRPS1 FES RYR1 ZNF710	2.26e-05	193	78	5	31c0978ba78c9516d498aec0798902e57555e557
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYT1L PTPRN GRM1 RYR2 CYFIP2	2.26e-05	193	78	5	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYT1L PTPRN GRM1 RYR2 CYFIP2	2.26e-05	193	78	5	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FES AHR ETV6 EIF2AK4 RYR1	2.32e-05	194	78	5	b16ed97eb6b7b7a220e943474c0d85c141b6e3a5
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FES AHR ETV6 EIF2AK4 RYR1	2.32e-05	194	78	5	2210f0755882d8f04edb4c109fb17c3f9149f6f7
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D231\|Adult / Lineage, Cell type, age group and donor	FOLR2 TRPS1 FES RYR1 ZNF710	2.32e-05	194	78	5	800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FOLR2 TRPS1 ETV6 RYR1 ZNF710	2.37e-05	195	78	5	247803cf58c6d9c561a52aa34e581188ddad197e
ToppCell	PBMC-Control-Myeloid-cDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FES AHR EIF2AK4 UVRAG RYR1	2.43e-05	196	78	5	e1f763fa9c11bf5f4d80e79f70f9485724ac23fe
ToppCell	Children_(3_yrs)-Immune-monocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRPS1 ETV6 CTSS MAP3K3 ZNF710	2.43e-05	196	78	5	cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCell	PBMC-Control-Myeloid-cDC-cDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FES AHR EIF2AK4 UVRAG RYR1	2.43e-05	196	78	5	553c22c7d48f3b4f6f2b2f10d6e668c5ebb09e8c
ToppCell	PBMC-Control-Myeloid-cDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FES AHR EIF2AK4 UVRAG RYR1	2.43e-05	196	78	5	d376168e15ec1cf618723259966c76be3698b9b0
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AGBL4 PDE1A PDE9A TRPS1 CYFIP2	2.43e-05	196	78	5	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	PBMC-Control-Myeloid-cDC-cDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FES AHR EIF2AK4 UVRAG RYR1	2.43e-05	196	78	5	4a9095ba3f6709f88f32bf09184553f4bd211f43
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TRPS1 ETV6 CTSS RYR1 ZNF710	2.49e-05	197	78	5	8af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCell	COVID-19_Mild\|World / Disease condition and Cell class	FLNA AHR ETV6 SPAG9 MX1	2.55e-05	198	78	5	61ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	LIMK2 AHR SPAG9 DENND3 MAP3K3	2.55e-05	198	78	5	d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCell	Immune-monocyte\|World / Lineage, Cell type, age group and donor	TRPS1 ETV6 CTSS MAP3K3 ZNF710	2.55e-05	198	78	5	d3622da252fd580f1dc5c7478a8e23df5ec083cf
ToppCell	control-HLA-DR+_CD83+_Monocyte\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FAM20C FES AHR MAP3K3 MX1	2.61e-05	199	78	5	f1b370d2869ad29c9d8ff41fdcc486fffa781ee2
ToppCell	Children_(3_yrs)-Immune-monocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRPS1 ETV6 CTSS MAP3K3 ZNF710	2.68e-05	200	78	5	881ab995c90d75fd987d6e8f1f926a4bfcc4235f
ToppCell	control-cDC\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FES AHR ETV6 EIF2AK4 RYR1	2.68e-05	200	78	5	4a6d17a4225be38537d3dd8a39512051f597f4e0
ToppCell	COVID-19-kidney-Technical/muscle_(EC)\|kidney / Disease (COVID-19 only), tissue and cell type	MYT1L GRM3 GRM7 RYR1	1.04e-04	139	78	4	64c35411bbe67acb5010dadc4b0b1be0f8b17737
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	MYT1L GRM1 GRM7 RYR2	1.26e-04	146	78	4	c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCell	facs-Pancreas-Exocrine-3m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOLR2 BTNL2 FES CTSS	1.33e-04	148	78	4	bbf4933582b50b3412c805de5ed137107c996236
ToppCell	facs-Pancreas-Exocrine-3m-Hematologic-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOLR2 BTNL2 FES CTSS	1.33e-04	148	78	4	6543860e3207a7de92a35bb6004be51287582f7a
ToppCell	facs-Pancreas-Exocrine-3m-Hematologic\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOLR2 BTNL2 FES CTSS	1.33e-04	148	78	4	79e376503a3f9504a1ec5af4a60a09cc80e19059
ToppCell	PND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BNIP5 DNAH10 TSHR SPAG6	1.43e-04	151	78	4	e335dad89e0a44cdd302b9653154ba5d1ee5fe1a
ToppCell	PND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BNIP5 DNAH10 TSHR SPAG6	1.43e-04	151	78	4	633ed52dd3b4cf1e87432cf0a1ca187d7b204e83
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ELMO3 EFNA2 TSHR RYR2	1.62e-04	156	78	4	574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ELMO3 EFNA2 TSHR RYR2	1.62e-04	156	78	4	605d95a900e1443d3f6aae163ef2e893d3293203
ToppCell	PBMC-Control-cDC_1\|Control / Compartment, Disease Groups and Clusters	HELZ2 WLS GRM7 MX1	1.62e-04	156	78	4	9b6c5bcac516a62bcc1f5be32ffa8c92735ef0bc
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AGBL4 ARSB RYR1 CYFIP2	1.62e-04	156	78	4	af47a4b17342bdb3cb62d7e2d52a81168e588629
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Lypd1_Gpr88\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	AGBL4 DNAH10 GRM2 GRM3	1.67e-04	157	78	4	5aee90ad7aaa65fdabc23597451da5e48db8f4e6
ToppCell	Control-Endothelial-Epi-like\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LIMK1 DNAH10 NT5E RNPEPL1	1.67e-04	157	78	4	4d02c50d5d1b892ea241e98724386d8a5a156a46
ToppCell	Control-Endothelial-Epi-like-Alv_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LIMK1 DNAH10 NT5E RNPEPL1	1.67e-04	157	78	4	2c369660c752c0fb3bd798a561d3359e2f9aa983
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-cortical_neurons_1\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	AGBL4 FAM20C TRPS1 ASIC3	1.71e-04	158	78	4	1f94622186d8329357fa06785e03eeacf29ab1ce
ToppCell	droplet-Lung-3m-Hematologic-myeloid-interstitial_macrophage\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TANC2 FOLR2 BTNL2 CTSS	1.71e-04	158	78	4	9a6d9b541446a6aa9f8ed040b330dbb5c6447076
ToppCell	droplet-Lung-3m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l12\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TANC2 FOLR2 BTNL2 CTSS	1.71e-04	158	78	4	2438713d2a7e32c647ab3384237ed614f4ec8fec
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	MYT1L GRM7 RYR1 RYR2	1.75e-04	159	78	4	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A TCAIM GRM1 CYFIP2	1.79e-04	160	78	4	03b88dc7ad41c6ae443cab7e77ec666340bf432e
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC1\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AGBL4 ARSB RYR1 CYFIP2	1.83e-04	161	78	4	0e2b54a63781397f6b99eb0e201fbb820cbd7cc6
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ERBB3 LIMK2 KIAA1217 AHR	1.83e-04	161	78	4	2d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOLR2 FES CTSS RYR1	1.83e-04	161	78	4	787f91f906756ef570c0d02936c3cdfafb3f7454
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOLR2 FES CTSS RYR1	1.83e-04	161	78	4	3db97af49520dc8cbafb4454d8afd9d588160e89
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOLR2 FES CTSS RYR1	1.83e-04	161	78	4	f1d258c81bcf0f3c52bd20aa58faa9a5fd888168
ToppCell	facs-Lung-nan-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA ETV6 CTSS CYFIP2	1.88e-04	162	78	4	3fd6aaf0fbaffc7ab38aa25e46c37ef511e1e704
ToppCell	facs-Lung-nan-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA ETV6 CTSS CYFIP2	1.88e-04	162	78	4	8134f73eb76693f4f1845f643042fdc1e81c274c
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFNA2 TRPS1 ETV6 CYFIP2	1.88e-04	162	78	4	93bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	MYT1L GRM7 RYR1 RYR2	1.92e-04	163	78	4	19c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 DNAH10 ZNF532 MX1	1.92e-04	163	78	4	8dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCell	droplet-Lung-3m-Hematologic-myeloid-non-classical_monocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CTSS RYR1 CYFIP2 ZNF710	1.92e-04	163	78	4	f6c8db5963ee1f8e0c2996f1aeecd58c00e9b099
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 DNAH10 ZNF532 MX1	1.92e-04	163	78	4	fd243ca223079033be480a24817a399f281fa4d4
ToppCell	facs-MAT-Fat-3m-Myeloid-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOLR2 FES CTSS RYR1	1.97e-04	164	78	4	1250876abd7311f86730e5b9c03c3610cc2ff6d3
ToppCell	droplet-Lung-3m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CTSS RYR1 CYFIP2 ZNF710	1.97e-04	164	78	4	ea2897942ad72fba900c7ab354d6a9e203bf0e4a
ToppCell	facs-MAT-Fat-3m-Myeloid\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOLR2 FES CTSS RYR1	1.97e-04	164	78	4	fa0d77b648cde5e42b9394e877168c80de238bde
ToppCell	droplet-Lung-3m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FES UVRAG CTSS RYR1	1.97e-04	164	78	4	cfe07a1ebed8aecb08d0476db71fe314998d54aa
ToppCell	droplet-Lung-3m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FES UVRAG CTSS RYR1	1.97e-04	164	78	4	6d331e74efecb4733d87653f86cd67247be05025
ToppCell	facs-MAT-Fat-3m-Myeloid-macrophage\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FES ETV6 CTSS RYR1	1.97e-04	164	78	4	b81498c3934e0d52bf0329dc745e02966f9d8613
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH10 FOLR2 STXBP4 GRM7	2.01e-04	165	78	4	1703d3eb644b3c743ad3c5532b1d29ea010c79c8
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNA CTSS RYR1 CYFIP2	2.16e-04	168	78	4	4b5be7c6662eceddf90a65015f12908278d1664e
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNA CTSS RYR1 CYFIP2	2.16e-04	168	78	4	689c41f6e9f65381570991cc311cba49a57ec955
ToppCell	droplet-Lung-nan-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA CTSS RYR1 CYFIP2	2.21e-04	169	78	4	ba023ee7bb165c2bfbefc2d969ff32ca1eeed33b
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_ETV4\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE9A KIAA1217 TRPS1 ZNF658B	2.21e-04	169	78	4	716e9d4c5fb99c56b76afaa5ed90bfa859fde802
ToppCell	droplet-Lung-nan-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA CTSS RYR1 CYFIP2	2.21e-04	169	78	4	c96e0f3241d13926dbee9f91c0c8c5bfa7479a0d
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination__)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BNIP5 PTPRN ANKRD50 DENND3	2.31e-04	171	78	4	d1e87478d8c0329e662849823f5c7604f20e1b1a
Drug	cis-MCG-I	GRM1 GRM2 GRM3 GRM4 GRM7	2.46e-11	8	79	5	CID003035584
Drug	mM PEP	GRM1 GRM2 GRM3 GRM4 GRM7	5.51e-11	9	79	5	CID005311462
Drug	AC1N21PP	GRM1 GRM2 GRM3 GRM4 GRM7	5.51e-11	9	79	5	CID004014619
Drug	1,3-cyclopentanedicarboxylic acid	GRM1 GRM2 GRM3 GRM4 GRM7	5.51e-11	9	79	5	CID000107216
Drug	NS-105	GRM1 GRM2 GRM3 GRM4 GRM7	1.10e-10	10	79	5	CID000198695
Drug	cyclobutylene AP5	GRM1 GRM2 GRM3 GRM4 GRM7	2.01e-10	11	79	5	CID000126582
Drug	Mspg	GRM1 GRM2 GRM3 GRM4 GRM7	5.57e-10	13	79	5	CID003964410
Drug	MSOPPE	GRM1 GRM2 GRM3 GRM4 GRM7	5.57e-10	13	79	5	CID005311463
Drug	AC1NSKBB	GRM1 GRM2 GRM3 GRM4 GRM7	5.57e-10	13	79	5	CID005311256
Drug	MTPG	GRM1 GRM2 GRM3 GRM4 GRM7	8.64e-10	14	79	5	CID005311456
Drug	2-methyl-6-styrylpyridine	GRM1 GRM2 GRM3 GRM4 GRM7	8.64e-10	14	79	5	CID000235382
Drug	ethylglutamate	GRM1 GRM2 GRM3 GRM4 GRM7	1.87e-09	16	79	5	CID000014241
Drug	2-PMPA	GRM1 GRM2 GRM3 GRM4 GRM7	1.87e-09	16	79	5	CID010130754
Drug	3HPG	GRM1 GRM2 GRM3 GRM4 GRM7	2.65e-09	17	79	5	CID000001217
Drug	acromelic acid A	GRM1 GRM2 GRM3 GRM4 GRM7	3.66e-09	18	79	5	CID000108086
Drug	aminocyclopentane	GRM1 GRM2 GRM3 GRM4 GRM7	4.95e-09	19	79	5	CID000002906
Drug	Aspartylglutamate	TBCCD1 TSHR GRM1 GRM2 GRM3 GRM4	5.03e-09	40	79	6	CID000151403
Drug	4-carboxy-3-hydroxyphenylglycine	GRM1 GRM2 GRM3 GRM4 GRM7	6.58e-09	20	79	5	CID000001297
Drug	LY341495	GRM1 GRM2 GRM3 GRM4 GRM7 RYR1	7.92e-09	43	79	6	CID006324636
Drug	3,4-dihydroxyphenylglycine	GRM1 GRM2 GRM3 GRM4 GRM7	8.62e-09	21	79	5	CID000027915
Drug	MSOP	GRM1 GRM2 GRM3 GRM4 GRM7	1.42e-08	23	79	5	CID003964633
Drug	phorbol 12,13-diacetate	SPAG9 GRM1 GRM2 GRM3 GRM4 GRM7	1.57e-08	48	79	6	CID000072293
Drug	RS)-2-chloro-5-hydroxyphenylglycine	GRM1 GRM2 GRM3 GRM4 GRM7	1.79e-08	24	79	5	CID003645780
Drug	AC1NQH9B	GRM1 GRM2 GRM3 GRM4 GRM7	2.75e-08	26	79	5	CID005221504
Drug	PBDA	GRM1 GRM2 GRM3 GRM4 GRM7	5.89e-08	30	79	5	CID000004408
Drug	alpha-methyl-4-carboxyphenylglycine	GRM1 GRM2 GRM3 GRM4 GRM7	8.28e-08	32	79	5	CID000001222
Drug	1-aminoindan-1,5-dicarboxylic acid	GRM1 GRM2 GRM3 GRM4 GRM7	9.73e-08	33	79	5	CID000002071
Drug	CPPG	GRM1 GRM2 GRM3 GRM4 GRM7	1.14e-07	34	79	5	CID000002878
Drug	1m5d	GRM1 GRM2 GRM3 GRM4 GRM7	1.32e-07	35	79	5	CID000447082
Drug	Cbpg	GRM1 GRM2 GRM4	1.60e-07	4	79	3	CID005311040
Drug	riluzole	ASIC3 GRM1 GRM2 GRM3 GRM4 GRM7 RYR1 RYR2	1.63e-07	174	79	8	CID000005070
Drug	benzyloxyaspartate	GRM1 GRM2 GRM3 GRM4 GRM7	1.77e-07	37	79	5	CID004133412
Drug	L-BMAA	GRM1 GRM2 GRM3 GRM4 GRM7	2.03e-07	38	79	5	CID000028558
Drug	4CPG	GRM1 GRM2 GRM3 GRM4 GRM7	2.03e-07	38	79	5	CID000005115
Drug	4-aminopyrrolidine-2,4-dicarboxylate	GRM1 GRM2 GRM3 GRM4 GRM7	2.32e-07	39	79	5	CID003331970
Drug	DETC-MeSO	GRM1 GRM2 GRM3 GRM4 GRM7	2.32e-07	39	79	5	CID003035711
Drug	L000369	GRM1 GRM2 GRM3 GRM4 GRM7	3.01e-07	41	79	5	CID003931705
Drug	AC1NNRU4	GRM1 GRM2 GRM3 GRM4 GRM7	3.01e-07	41	79	5	CID005126051
Drug	butenafine	GRM1 GRM2 GRM3 GRM4 GRM7	3.40e-07	42	79	5	CID000002484
Drug	Joro spider toxin	GRM1 GRM2 GRM3 GRM4 GRM7	3.84e-07	43	79	5	CID000119582
Drug	Acamprosate	GRM1 GRM2 GRM3	4.00e-07	5	79	3	DB00659
Drug	D-N-Q	NT5E GRM1 GRM2 GRM3 GRM4 GRM7	4.72e-07	84	79	6	CID000003140
Drug	AC1L1BXF	NT5E GRM1 GRM2 GRM3 GRM4 GRM7	5.06e-07	85	79	6	CID000001650
Drug	cysteine sulfinic acid	GRM1 GRM2 GRM3 GRM4 GRM7	5.42e-07	46	79	5	CID000000109
Drug	IPSP	SPAG9 GRM1 GRM2 GRM3 GRM4 GRM7	5.81e-07	87	79	6	CID000022083
Drug	nimodipine	GRM1 GRM2 GRM3 GRM4 GRM7 RYR1 RYR2	7.26e-07	145	79	7	CID000004497
Drug	Dantrolene-13C3	GRM1 GRM2 GRM3 GRM4 GRM7 RYR1 RYR2	7.26e-07	145	79	7	CID000002951
Drug	methylenecyclopropylglycine	GRM1 GRM2 GRM3 GRM4 GRM7	7.48e-07	49	79	5	CID000441452
Drug	2-amino-4-phosphonobutyric acid	GRM1 GRM2 GRM3 GRM4 GRM7 RYR1	7.59e-07	91	79	6	CID000002207
Drug	AC1MBZ3L	GRM1 GRM2 GRM4	7.98e-07	6	79	3	CID002733524
Drug	L-CCG-I	GRM1 GRM2 GRM3 GRM4 GRM7	8.29e-07	50	79	5	CID000001271
Drug	LY354740	GRM1 GRM2 GRM3 GRM4 GRM7	9.17e-07	51	79	5	CID000114827
Drug	AC1L1EKQ	GRM1 GRM2 GRM3 GRM4 GRM7	1.01e-06	52	79	5	CID000002834
Drug	N-Ac-D-E	GRM1 GRM2 GRM3 GRM4 GRM7	1.11e-06	53	79	5	CID000005255
Drug	2-phenylglycine	GRM1 GRM2 GRM3 GRM4 GRM7	1.34e-06	55	79	5	CID000003866
Drug	azetidine-2,4-dicarboxylic acid	GRM1 GRM2 GRM3	1.39e-06	7	79	3	CID000005370
Drug	GYKI 52466	GRM1 GRM2 GRM3 GRM4 GRM7	1.76e-06	58	79	5	CID000003538
Drug	MPEP	GRM1 GRM2 GRM3 GRM4 GRM7	1.91e-06	59	79	5	CID003025961
Drug	3,5-dihydroxyphenylglycine	GRM1 GRM2 GRM3 GRM4 GRM7	2.08e-06	60	79	5	CID000108001
Drug	pyrrolidine-2,4-dicarboxylate	GRM1 GRM2 GRM3 GRM4 GRM7	2.26e-06	61	79	5	CID000003868
Drug	rolipram	PDE1A PDE9A AHR GRM1 GRM2 GRM3 GRM4 GRM7	2.75e-06	253	79	8	CID000005092
Drug	cyclizine	SEL1L ERBB3 GRM2 GRM3 GRM4 GRM7	3.15e-06	116	79	6	CID000006726
Drug	homocysteic acid	GRM1 GRM2 GRM3 GRM4 GRM7	3.35e-06	66	79	5	CID000092117
Drug	ketamine	ETV6 ASIC3 GRM1 GRM2 GRM3 GRM4 GRM7 RYR1	3.56e-06	262	79	8	CID000003821
Drug	DCG-IV	GRM1 GRM2 GRM3 GRM4 GRM7	3.89e-06	68	79	5	CID000115114
Drug	felbamate	GRM1 GRM2 GRM3 GRM4 GRM7	4.49e-06	70	79	5	CID000003331
Drug	baclofen	GRM1 GRM2 GRM3 GRM4 GRM7 RYR1 RYR2	4.56e-06	191	79	7	CID000002284
Drug	PCB 95	AHR RYR1 RYR2	4.74e-06	10	79	3	CID000038012
Drug	pSer	SHMT1 GRM1 GRM2 GRM3 GRM4 GRM7	5.09e-06	126	79	6	CID000000106
Drug	norbiotin	GRM1 GRM2 GRM3 GRM4 GRM7	5.16e-06	72	79	5	CID000446903
Drug	AC1L9FMM	GRM1 GRM2 GRM3 GRM4 GRM7	5.52e-06	73	79	5	CID000444055
Drug	isoflurane	ASIC3 GRM1 GRM2 GRM3 GRM4 GRM7 TRAPPC9 RYR1	5.65e-06	279	79	8	CID000003763
Drug	Isocarboxazid [59-63-2]; Up 200; 17.2uM; PC3; HT_HG-U133A	TANC2 LIMK2 RNPEPL1 SHMT1 GRM1 TRAPPC9 MX1	5.78e-06	198	79	7	7383_UP
Drug	C070379	GRM1 GRM2 GRM3 GRM4 GRM7 RYR1 RYR2	5.97e-06	199	79	7	CID003034747
Drug	AC1L1DME	GRM1 GRM2 GRM3 GRM4 GRM7	6.31e-06	75	79	5	CID000002414
Drug	2-amino-3-phosphonopropionic acid	GRM1 GRM2 GRM3 GRM4 GRM7	6.74e-06	76	79	5	CID000003857
Drug	AMN082	GRM1 GRM2 GRM7	8.65e-06	12	79	3	CID001894360
Drug	forskolin from Coleus forskohlii	PDE1A PDE9A NT5E AHR TSHR EIF2AK4 ASIC3 GRM1 GRM2 GRM3 GRM4 GRM7 RYR1 RYR2	9.10e-06	1013	79	14	CID000003413
Drug	ganciclovir	SHMT1 GRM1 GRM2 GRM3 GRM4 GRM7	9.33e-06	140	79	6	CID000003454
Drug	memantine	GRM1 GRM2 GRM3 GRM4 GRM7	1.24e-05	86	79	5	CID000004054
Drug	europium	FLNA PTPRN RYR1 RYR2 MAP3K3	1.31e-05	87	79	5	CID000023981
Drug	NSC298883	GRM1 GRM2 GRM3 GRM4 GRM7	1.46e-05	89	79	5	CID000326807
Drug	hexachlorophene	GRM1 GRM2 GRM3 GRM4 GRM7	1.54e-05	90	79	5	CID000003598
Drug	HA1 100	GRM1 GRM2 GRM3 GRM4 GRM7	1.54e-05	90	79	5	CID003064778
Drug	oriens	THOP1 GRM1 GRM2 GRM3 GRM4 GRM7	1.61e-05	154	79	6	CID000161645
Drug	aurintricarboxylic acid	GRM1 GRM2 GRM3 GRM4 GRM7	1.63e-05	91	79	5	CID000002259
Drug	3-(1H-pyrrole-2-carboxylate	GRM1 GRM2 GRM3 GRM4 GRM7 RYR1 RYR2	1.67e-05	233	79	7	CID000005114
Drug	caffeine	PDE1A PDE9A NT5E GRM1 GRM2 GRM3 GRM4 GRM7 RYR1 RYR2	2.42e-05	562	79	10	CID000002519
Drug	carbachol	PDE1A ERBB3 MYH13 AHR GRM1 GRM2 GRM3 GRM4 GRM7 RYR1 RYR2	2.47e-05	688	79	11	CID000002551
Drug	gabapentin	ASIC3 GRM1 GRM2 GRM3 RYR1 RYR2	2.72e-05	169	79	6	CID000003446
Drug	cyclothiazide	GRM1 GRM2 GRM3 GRM4 GRM7	2.97e-05	103	79	5	CID000002910
Drug	P12-sulfatide	ARSA ARSB	3.56e-05	3	79	2	CID006439241
Drug	cis-diammineplatinum(II	RYR1 RYR2	3.56e-05	3	79	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR1 RYR2	3.56e-05	3	79	2	CID002750949
Drug	8N3-cADPR	RYR1 RYR2	3.56e-05	3	79	2	CID000127713
Drug	aminodantrolene	RYR1 RYR2	3.56e-05	3	79	2	CID009570289
Drug	isospaglumic acid	GRM2 GRM3	3.56e-05	3	79	2	ctd:C027172
Drug	2-hydroxycarbazole	RYR1 RYR2	3.56e-05	3	79	2	CID000093551
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR2	3.56e-05	3	79	2	CID005748312
Drug	LY 379268	GRM2 GRM3	3.56e-05	3	79	2	ctd:C118218
Disease	Epilepsy, Benign Psychomotor, Childhood	GRM1 GRM2 GRM3 GRM4	3.65e-07	23	77	4	C0393672
Disease	Epilepsy, Lateral Temporal	GRM1 GRM2 GRM3 GRM4	3.65e-07	23	77	4	C0393682
Disease	Uncinate Epilepsy	GRM1 GRM2 GRM3 GRM4	3.65e-07	23	77	4	C0014558
Disease	Epilepsy, Temporal Lobe	GRM1 GRM2 GRM3 GRM4	3.65e-07	23	77	4	C0014556
Disease	serum IgG glycosylation measurement	DNAH10 GLI3 TRPS1 ETV6 TSHR GRM3 RYR2 CYFIP2 MX1	8.93e-06	523	77	9	EFO_0005193
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR2	2.01e-05	3	77	2	DOID:3529 (implicated_via_orthology)
Disease	Addicted to cocaine	GRM2 GRM3	2.01e-05	3	77	2	C0858355
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR2	2.01e-05	3	77	2	DOID:8545 (implicated_via_orthology)
Disease	Disproportionate short stature	FLNA FAM20C GLI3 TRPS1	5.02e-05	77	77	4	C0878659
Disease	Stomach Neoplasms	ERBB3 PDHA1 NT5E GLI3 AHR MX1	1.29e-04	297	77	6	C0038356
Disease	Malignant neoplasm of stomach	ERBB3 PDHA1 NT5E GLI3 AHR MX1	1.36e-04	300	77	6	C0024623
Disease	mitral valve prolapse (is_implicated_in)	FLNA TSHR	2.39e-04	9	77	2	DOID:988 (is_implicated_in)
Disease	Unipolar Depression	MYT1L ERBB3 ARSA GRM1 GRM7	5.92e-04	259	77	5	C0041696
Disease	Alcoholic Intoxication, Chronic	ARSA GRM1 GRM2 GRM3 GRM7	6.90e-04	268	77	5	C0001973
Disease	Williams-Beuren syndrome (implicated_via_orthology)	LIMK1 LIMK2	6.90e-04	15	77	2	DOID:1928 (implicated_via_orthology)
Disease	squamous cell carcinoma	TRPS1 AHR CTSS	7.26e-04	67	77	3	EFO_0000707
Disease	susceptibility to mononucleosis measurement	MYT1L ANKRD50 RYR2	7.91e-04	69	77	3	EFO_0008403
Disease	Tachycardia	AHR RYR2	1.00e-03	18	77	2	C0039231
Disease	Tachyarrhythmia	AHR RYR2	1.00e-03	18	77	2	C0080203
Disease	Hereditary Diffuse Gastric Cancer	PDHA1 NT5E GLI3 AHR MX1	1.03e-03	293	77	5	C1708349
Disease	osteochondrodysplasia (is_implicated_in)	FLNA TRPS1	1.12e-03	19	77	2	DOID:2256 (is_implicated_in)
Disease	mean reticulocyte volume	LIMK2 PTPRN KIAA1217 RNPEPL1 STXBP4 HELZ2 ETV6 TRAPPC9	1.13e-03	799	77	8	EFO_0010701
Disease	body surface area	AGBL4 ERBB3 SETD5 TRPS1 ETV6 MAP3K3 SPRYD7	1.45e-03	643	77	7	EFO_0022196
Disease	Attention Deficit Disorder	GRM1 GRM7	1.50e-03	22	77	2	C0041671
Disease	Minimal Brain Dysfunction	GRM1 GRM7	1.50e-03	22	77	2	C1321905
Disease	body weight	MYT1L AGBL4 KLHL24 PDE1A PTPRN KIAA1217 STXBP4 TRPS1 ETV6 GRM7	1.59e-03	1261	77	10	EFO_0004338
Disease	alcohol use disorder (implicated_via_orthology)	ERBB3 SHMT1 RYR1 RYR2	1.72e-03	195	77	4	DOID:1574 (implicated_via_orthology)
Disease	Attention deficit hyperactivity disorder	GRM1 GRM7	1.79e-03	24	77	2	C1263846
Disease	Neurodevelopmental Disorders	MYT1L TANC2 SETD5	1.87e-03	93	77	3	C1535926
Disease	albuminuria	AHR TSHR GRM7	1.93e-03	94	77	3	EFO_0004285
Disease	Schizophrenia	MYT1L ERBB3 SHMT1 GRM1 GRM2 GRM3 GRM4 GRM7	2.12e-03	883	77	8	C0036341
Disease	mean arterial pressure, alcohol drinking	PDE1A GLI3 FES	2.17e-03	98	77	3	EFO_0004329, EFO_0006340
Disease	Iniencephaly	FOLR2 GLI3	2.43e-03	28	77	2	C0152234
Disease	Acrania	FOLR2 GLI3	2.43e-03	28	77	2	C0702169
Disease	Tethered Cord Syndrome	FOLR2 GLI3	2.43e-03	28	77	2	C0080218
Disease	Spinal Cord Myelodysplasia	FOLR2 GLI3	2.43e-03	28	77	2	C0344479
Disease	Exencephaly	FOLR2 GLI3	2.43e-03	28	77	2	C0266453
Disease	Neurenteric Cyst	FOLR2 GLI3	2.43e-03	28	77	2	C0027806
Disease	Diastematomyelia	FOLR2 GLI3	2.43e-03	28	77	2	C0011999
Disease	Craniorachischisis	FOLR2 GLI3	2.61e-03	29	77	2	C0152426
Disease	pulmonary tuberculosis	MYT1L PIP5K1A	2.61e-03	29	77	2	EFO_1000049

Protein segments in the cluster

Peptide	Gene	Start	Entry
HAADMLYCAESHIRM	AHR	326	P35869
GMYYLEEHGMVHRNL	ERBB3	821	P21860
YEHNEAALFMDHSGM	EIF2AK4	1096	Q9P2K8
VHVYMDGDHVAGEQM	BTNL2	291	Q9UIR0
YAMAHALHNMHRALC	GRM2	386	Q14416
MFVVNAVYAMAHALH	GRM3	391	Q14832
DAVYAMGHALHAMHR	GRM4	411	Q14833
ESMLYLDGQRHFNSM	ACOT9	411	Q9Y305
LCNAAEGHRMLAMSY	ANKRD50	426	Q9ULJ7
QAYHAHFVSMLSEAM	DENND3	531	A2RUS2
QRHTEMIHNYMEHLE	SPAG9	161	O60271
LSHREDLAYMNHIMV	ETV6	306	P41212
TGHMILAYMEDHLRN	PTPRN	691	Q16849
AGTGAIHMEYLHAMD	GLI3	261	P10071
MRVPHFLQDHGRYME	KIAA0895	486	Q8NCT3
ASGMAYLHSMCIIHR	LIMK2	436	P53671
HHVSAAYRLMQEEEM	PDE1A	291	P54750
MLSCLEHMYHDLGLV	PDE9A	271	O76083
ICEGIRHMHQMYILH	MYLK4	211	Q86YV6
SRVDDHLMGKQHMGY	LUC7L3	206	O95232
GLEARYMAFAHDLMA	ARSA	196	P15289
MAQLYARAGHSLDDM	ASIC3	146	Q9UHC3
HSSMNEMLEEGHEYA	CYFIP2	66	Q96F07
HYMLRENLMASDHLD	ITGB4	761	P16144
MDYSLLMSIHNIDHA	PIP5K1A	321	Q99755
TAKNDMNRHLHEYME	IFFO1	486	Q0D2I5
MGHYDQSIAAVEMEH	FZD6	46	O60353
HEARRYHILGNEMMS	KLHL24	286	Q6TFL4
SHAMCILMGLRDHYN	BNIP5	616	P0C671
DFLMGNMDRHHYETF	FAM20C	451	Q8IXL6
EAGLHEMDIRYDNMH	FLNA	1836	P21333
FLHHQMGLCYRAQMI	IFIT1B	286	Q5T764
LEFYIDIHAHSTMMN	AGBL4	321	Q5VU57
RFYAAAMHVNAGEML	FOLR2	221	P14207
AAPMGDEMAHHLYVL	ELMO3	271	Q96BJ8
KNRHHYAGMVSLMDE	ARSB	261	P15848
MEHYVLYMVNGEGHA	EFNA2	86	O43921
VIDAVYAMAHALHHM	GRM7	411	Q14831
LHNLEHSMGMHSYDL	CTSS	61	P25774
HSYDLGMNHLGDMTS	CTSS	71	P25774
EDAHMLDTQYRMHEG	HELZ2	2416	Q9BYK8
AIYAMAHGLQNMHHA	GRM1	416	Q13255
AGIQRMLDHYHMLIG	DNAH10	706	Q8IVF4
MLDHYHMLIGTLNDA	DNAH10	711	Q8IVF4
FYQHPNLMRALGMHE	RYR1	2191	P21817
YQHPNLMRALGMHET	RYR2	2156	Q92736
SDVMFEHFLLHREGM	KIR2DL1	51	P43626
GMSYLHSNMIVHRDI	MAP3K3	476	Q99759
SDVMFEHFLLHREGM	KIR2DS1	51	Q14954
DREYAGLLHHMSLQD	FES	41	P07332
NGAYLMADMAHISGL	SHMT1	221	P34896
NFMEHGLMVRCDRHH	UVRAG	456	Q9P2Y5
RSAYMEEEGVFHFHM	RNPEPL1	236	Q9HAU8
GMHLCISHFYSVMQD	TCAIM	466	Q8N3R3
MLGYVAAHSENLAMA	SPAG6	316	O75602
DHIMRNGLDYNELAM	TBC1D25	631	Q3MII6
QHSAQAMFNLGYMHE	SEL1L	661	Q9UBV2
SMYGDFQEAMTHLQH	TENT5D	206	Q8NEK8
AMLHYADMLDILSHT	SPPL2C	151	Q8IUH8
HRVSDLRMIDMHAHY	KIAA1217	476	Q5T5P2
LRMIDMHAHYNAHGP	KIAA1217	481	Q5T5P2
RHMIADGMIHLCIYA	SETD5	361	Q9C0A6
VDHGAMIEHVDYSGM	TANC2	1186	Q9HCD6
AEAAQRQAHGMEMDY	STXBP4	356	Q6ZWJ1
DMHSLVMRNDGALYH	SPRYD7	96	Q5W111
VAHFMNALRYDAMAL	NT5E	101	P21589
DEVMYALHMSCHGDS	TRPS1	1226	Q9UHF7
EAALNTHMRTHGMAF	ZNF532	1276	Q9HCE3
LRGMMLYHHGSLQEA	TTC13	356	Q8NBP0
LMELQTYRYHGHSMS	PDHA1	281	P08559
FNRMYNLLGHMHLHA	ZNF710	556	Q8N1W2
GVMDHYLVMHQLRCN	MYH13	686	Q9UKX3
HMAMTHYECNERGIN	ZNF658	291	Q5TYW1
AGMLQDSLVHYHMSV	TRAPPC9	216	Q96Q05
THYPMLEDHMARTGL	TBCCD1	421	Q9NVR7
RHMASMHEDISNFYS	ZNF142	236	P52746
EHMMDQHERNHIAGY	WLS	321	Q5T9L3
GFHTHADYVLEMNMA	THOP1	271	P52888
HDMRQGLHNMEDVYE	TSHR	726	P16473
VHMAMTHYECNERGI	ZNF658B	46	Q4V348
SGMAYLHSMNIIHRD	LIMK1	446	P53667
DSSMEEIFQHLMAYH	MX1	571	P20591
DYTHDMEAAHMAATA	MYT1L	721	Q9UL68