Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF671 ZNF672 HIVEP1 ZNF628 ZNF157 ZNF165 ZNF460 ZKSCAN8 ZNF629 ZKSCAN2 YBX3 RELB ZNF236 ZNF623 ZNF416 ZNF441 ZNF551 ZSCAN5B ZNF526 GZF1 WIZ ZNF530 MZF1 ZNF648 ZNF256 ZNF814 ZNF782 ZNF439 ZNF281 ZNF548 TP73 PROP1 ZNF574	9.94e-15	1459	95	33	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF672 HIVEP1 ZNF628 ZNF157 ZNF165 ZNF460 ZKSCAN8 ZNF629 ZKSCAN2 RELB ZNF236 ZNF623 ZNF416 ZNF441 ZNF551 ZSCAN5B ZNF526 GZF1 WIZ ZNF530 MZF1 ZNF648 ZNF256 ZNF814 ZNF782 ZNF439 ZNF281 ZNF548 TP73 PROP1 ZNF574	1.85e-13	1412	95	31	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF671 HIVEP1 ZNF628 ZNF157 ZNF165 ZNF460 ZKSCAN8 ZNF629 ZKSCAN2 RELB ZNF236 ZNF623 ZNF416 ZNF551 ZSCAN5B ZNF526 GZF1 WIZ ZNF530 MZF1 ZNF648 ZNF256 ZNF814 ZNF782 ZNF281 ZNF548 TP73 PROP1 ZNF574	3.16e-13	1244	95	29	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF671 HIVEP1 ZNF628 ZNF157 ZNF165 ZNF460 ZKSCAN8 ZNF629 ZKSCAN2 RELB ZNF236 ZNF623 ZNF416 ZNF551 ZSCAN5B ZNF526 GZF1 WIZ ZNF530 MZF1 ZNF648 ZNF256 ZNF814 ZNF782 ZNF281 ZNF548 TP73 PROP1 ZNF574	5.41e-13	1271	95	29	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF628 ZNF629 RELB GZF1 MZF1 ZNF814 ZNF782 TP73 PROP1 ZNF574	3.31e-04	560	95	10	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF628 ZNF629 RELB GZF1 MZF1 ZNF814 ZNF782 TP73 PROP1 ZNF574	3.60e-04	566	95	10	GO:0001216
GeneOntologyMolecularFunction	superoxide-generating NADPH oxidase activator activity	NCF1C NCF1B	9.83e-04	10	95	2	GO:0016176
GeneOntologyMolecularFunction	cAMP response element binding protein binding	CRTC3 CRTC2	1.43e-03	12	95	2	GO:0008140
GeneOntologyMolecularFunction	superoxide-generating NAD(P)H oxidase activity	NCF1C NCF1B	1.43e-03	12	95	2	GO:0016175
Domain	Znf_C2H2-like	ZNF671 ZNF672 HIVEP1 ZNF628 ZNF157 ZNF165 ZNF460 APTX ZKSCAN8 ZNF629 ZKSCAN2 ZNF236 ZNF623 ZNF416 ZNF441 ZNF551 ZSCAN5B ZNF526 GZF1 WIZ ZNF530 MZF1 ZNF648 ZNF256 ZNF814 ZFTA ZNF782 ZNF439 ZNF281 ZNF548 ZNF574	1.52e-20	796	89	31	IPR015880
Domain	ZnF_C2H2	ZNF671 ZNF672 HIVEP1 ZNF628 ZNF157 ZNF165 ZNF460 APTX ZKSCAN8 ZNF629 ZKSCAN2 ZNF236 ZNF623 ZNF416 ZNF441 ZNF551 ZSCAN5B ZNF526 GZF1 WIZ ZNF530 MZF1 ZNF648 ZNF256 ZNF814 ZFTA ZNF782 ZNF439 ZNF281 ZNF548 ZNF574	2.35e-20	808	89	31	SM00355
Domain	ZINC_FINGER_C2H2_2	ZNF671 ZNF672 HIVEP1 ZNF628 ZNF157 ZNF165 ZNF460 APTX ZKSCAN8 ZNF629 ZKSCAN2 ZNF236 ZNF623 ZNF416 ZNF441 ZNF551 ZSCAN5B ZNF526 GZF1 WIZ ZNF530 MZF1 ZNF648 ZNF256 ZNF814 ZNF782 ZNF439 ZNF281 ZNF548 ZNF574	8.80e-20	775	89	30	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF671 ZNF672 HIVEP1 ZNF628 ZNF157 ZNF165 ZNF460 APTX ZKSCAN8 ZNF629 ZKSCAN2 ZNF236 ZNF623 ZNF416 ZNF441 ZNF551 ZSCAN5B ZNF526 GZF1 WIZ ZNF530 MZF1 ZNF648 ZNF256 ZNF814 ZNF782 ZNF439 ZNF281 ZNF548 ZNF574	9.46e-20	777	89	30	PS00028
Domain	Znf_C2H2	ZNF671 ZNF672 HIVEP1 ZNF628 ZNF157 ZNF165 ZNF460 APTX ZKSCAN8 ZNF629 ZKSCAN2 ZNF236 ZNF623 ZNF416 ZNF441 ZNF551 ZSCAN5B ZNF526 GZF1 WIZ ZNF530 MZF1 ZNF648 ZNF256 ZNF814 ZNF782 ZNF439 ZNF281 ZNF548 ZNF574	2.55e-19	805	89	30	IPR007087
Domain	-	ZNF671 ZNF672 HIVEP1 ZNF628 ZNF157 ZNF165 ZNF460 ZKSCAN8 ZNF629 ZKSCAN2 ZNF236 ZNF623 ZNF416 ZNF441 ZNF551 ZSCAN5B ZNF526 GZF1 ZNF530 MZF1 ZNF648 ZNF256 ZNF814 ZNF782 ZNF439 ZNF281 ZNF548 ZNF574	3.79e-19	679	89	28	3.30.160.60
Domain	zf-C2H2	ZNF671 ZNF672 HIVEP1 ZNF628 ZNF157 ZNF165 ZNF460 ZKSCAN8 ZNF629 ZKSCAN2 ZNF236 ZNF623 ZNF416 ZNF441 ZNF551 ZSCAN5B ZNF526 GZF1 ZNF530 MZF1 ZNF648 ZNF256 ZNF814 ZNF782 ZNF439 ZNF281 ZNF548 ZNF574	6.49e-19	693	89	28	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF671 ZNF672 HIVEP1 ZNF628 ZNF157 ZNF165 ZNF460 ZKSCAN8 ZNF629 ZKSCAN2 ZNF236 ZNF623 ZNF416 ZNF441 ZNF551 ZSCAN5B ZNF526 GZF1 ZNF530 MZF1 ZNF648 ZNF256 ZNF814 ZNF782 ZNF439 ZNF281 ZNF548 ZNF574	6.74e-19	694	89	28	IPR013087
Domain	zf-C2H2_6	ZNF671 ZNF672 ZNF157 ZKSCAN8 ZNF236 ZNF416 ZNF551 ZSCAN5B ZNF526 GZF1 ZNF530 ZNF256 ZNF814 ZNF782 ZNF439 ZNF548 ZNF574	1.13e-13	314	89	17	PF13912
Domain	KRAB	ZNF671 ZNF157 ZNF460 ZKSCAN8 ZKSCAN2 ZNF416 ZNF783 ZNF441 ZNF551 ZNF530 ZNF256 ZNF814 ZNF782 ZNF439 ZNF548	1.37e-10	358	89	15	PS50805
Domain	KRAB	ZNF671 ZNF157 ZNF460 ZKSCAN8 ZKSCAN2 ZNF416 ZNF783 ZNF441 ZNF551 ZNF530 ZNF256 ZNF814 ZNF782 ZNF439 ZNF548	1.37e-10	358	89	15	PF01352
Domain	KRAB	ZNF671 ZNF157 ZNF460 ZKSCAN8 ZKSCAN2 ZNF416 ZNF783 ZNF441 ZNF551 ZNF530 ZNF256 ZNF814 ZNF782 ZNF439 ZNF548	2.08e-10	369	89	15	SM00349
Domain	KRAB	ZNF671 ZNF157 ZNF460 ZKSCAN8 ZKSCAN2 ZNF416 ZNF783 ZNF441 ZNF551 ZNF530 ZNF256 ZNF814 ZNF782 ZNF439 ZNF548	2.16e-10	370	89	15	IPR001909
Domain	SCAN	ZNF165 ZKSCAN8 ZKSCAN2 ZSCAN5B MZF1	6.92e-06	56	89	5	SM00431
Domain	SCAN_BOX	ZNF165 ZKSCAN8 ZKSCAN2 ZSCAN5B MZF1	8.24e-06	58	89	5	PS50804
Domain	SCAN	ZNF165 ZKSCAN8 ZKSCAN2 ZSCAN5B MZF1	8.24e-06	58	89	5	PF02023
Domain	SCAN_dom	ZNF165 ZKSCAN8 ZKSCAN2 ZSCAN5B MZF1	8.24e-06	58	89	5	IPR003309
Domain	Retrov_capsid_C	ZNF165 ZKSCAN8 ZKSCAN2 ZSCAN5B MZF1	8.97e-06	59	89	5	IPR008916
Domain	PLAC	PCSK5 PCSK6 ADAMTS16	3.67e-05	14	89	3	PF08686
Domain	TORC_N	CRTC3 CRTC2	6.72e-05	3	89	2	IPR024783
Domain	TORC	CRTC3 CRTC2	6.72e-05	3	89	2	IPR024786
Domain	TORC_M	CRTC3 CRTC2	6.72e-05	3	89	2	IPR024784
Domain	TORC_C	CRTC3 CRTC2	6.72e-05	3	89	2	IPR024785
Domain	TORC_N	CRTC3 CRTC2	6.72e-05	3	89	2	PF12884
Domain	TORC_M	CRTC3 CRTC2	6.72e-05	3	89	2	PF12885
Domain	TORC_C	CRTC3 CRTC2	6.72e-05	3	89	2	PF12886
Domain	PLAC	PCSK5 PCSK6 ADAMTS16	9.59e-05	19	89	3	PS50900
Domain	PLAC	PCSK5 PCSK6 ADAMTS16	9.59e-05	19	89	3	IPR010909
Domain	EGF	PCSK5 LAMA2 ADAM11 GPR179 SNED1 PCSK6 TENM1	1.31e-04	235	89	7	SM00181
Domain	Anion_exchange	SLC4A7 SLC4A3	2.22e-04	5	89	2	IPR001717
Domain	SAPAP	DLGAP2 DLGAP4	2.22e-04	5	89	2	IPR005026
Domain	GKAP	DLGAP2 DLGAP4	2.22e-04	5	89	2	PF03359
Domain	DMAP_binding	DIP2A DIP2C	2.22e-04	5	89	2	PF06464
Domain	GF_recep_IV	PCSK5 PCSK6	3.33e-04	6	89	2	PF14843
Domain	DMAP1-bd	DIP2A DIP2C	3.33e-04	6	89	2	IPR010506
Domain	GF_recep_IV	PCSK5 PCSK6	3.33e-04	6	89	2	IPR032778
Domain	Peptidase_S8_Asp-AS	PCSK5 PCSK6	3.33e-04	6	89	2	IPR023827
Domain	DMAP_binding	DIP2A DIP2C	3.33e-04	6	89	2	SM01137
Domain	AMP-binding	DIP2A SLC27A1 DIP2C	3.87e-04	30	89	3	PF00501
Domain	AMP-dep_Synth/Lig	DIP2A SLC27A1 DIP2C	3.87e-04	30	89	3	IPR000873
Domain	PrprotnconvertsP	PCSK5 PCSK6	4.64e-04	7	89	2	IPR002884
Domain	ANION_EXCHANGER_2	SLC4A7 SLC4A3	4.64e-04	7	89	2	PS00220
Domain	ANION_EXCHANGER_1	SLC4A7 SLC4A3	4.64e-04	7	89	2	PS00219
Domain	P_proprotein	PCSK5 PCSK6	4.64e-04	7	89	2	PF01483
Domain	S8_pro-domain	PCSK5 PCSK6	4.64e-04	7	89	2	IPR032815
Domain	-	PCSK5 PCSK6	4.64e-04	7	89	2	3.30.70.850
Domain	S8_pro-domain	PCSK5 PCSK6	4.64e-04	7	89	2	PF16470
Domain	Peptidase_S8_His-AS	PCSK5 PCSK6	7.91e-04	9	89	2	IPR022398
Domain	Band3_cytoplasmic_dom	SLC4A7 SLC4A3	7.91e-04	9	89	2	IPR013769
Domain	Band_3_cyto	SLC4A7 SLC4A3	7.91e-04	9	89	2	PF07565
Domain	-	SLC4A7 SLC4A3	7.91e-04	9	89	2	3.40.1100.10
Domain	Peptidase_S8_Ser-AS	PCSK5 PCSK6	7.91e-04	9	89	2	IPR023828
Domain	Peptidase_S8_subtilisin-rel	PCSK5 PCSK6	9.86e-04	10	89	2	IPR015500
Domain	HCO3_cotransp	SLC4A7 SLC4A3	9.86e-04	10	89	2	PF00955
Domain	HCO3_transpt_C	SLC4A7 SLC4A3	9.86e-04	10	89	2	IPR011531
Domain	PTrfase/Anion_transptr	SLC4A7 SLC4A3	9.86e-04	10	89	2	IPR016152
Domain	HCO3_transpt_euk	SLC4A7 SLC4A3	9.86e-04	10	89	2	IPR003020
Domain	SUBTILASE_ASP	PCSK5 PCSK6	9.86e-04	10	89	2	PS00136
Domain	SUBTILASE_HIS	PCSK5 PCSK6	9.86e-04	10	89	2	PS00137
Domain	SUBTILASE_SER	PCSK5 PCSK6	9.86e-04	10	89	2	PS00138
Domain	-	PCSK5 PCSK6	1.20e-03	11	89	2	3.40.50.200
Domain	Peptidase_S8/S53_dom	PCSK5 PCSK6	1.20e-03	11	89	2	IPR000209
Domain	Peptidase_S8	PCSK5 PCSK6	1.20e-03	11	89	2	PF00082
Domain	EGF-like_dom	PCSK5 LAMA2 ADAM11 SNED1 PCSK6 TENM1	1.22e-03	249	89	6	IPR000742
Domain	Propept_inh	PCSK5 PCSK6	2.91e-03	17	89	2	IPR009020
Domain	Furin_repeat	PCSK5 PCSK6	3.27e-03	18	89	2	IPR006212
Domain	FU	PCSK5 PCSK6	3.27e-03	18	89	2	SM00261
Domain	-	PCSK5 LAMA2 PCSK6	5.11e-03	73	89	3	2.60.120.260
Domain	ADAM_spacer1	ADAMTSL5 ADAMTS16	5.32e-03	23	89	2	IPR010294
Domain	ADAM_spacer1	ADAMTSL5 ADAMTS16	5.32e-03	23	89	2	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTSL5 ADAMTS16	5.79e-03	24	89	2	IPR013273
Domain	C2H2_Znf_fam	ZKSCAN2 ZSCAN5B	5.79e-03	24	89	2	IPR027775
Domain	AMP_BINDING	SLC27A1 DIP2C	7.83e-03	28	89	2	PS00455
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	ATP8B3 HIVEP1 SLC4A7 APTX ZKSCAN8 ADAM11 ZNF236 DIP2A TBC1D10B MZF1 VANGL1 ARMC5 ZNF281 TP73	3.31e-07	925	98	14	28986522
Pubmed	Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog.	DIP2A DIP2C	7.86e-06	2	98	2	12137943
Pubmed	Creb coactivators direct anabolic responses and enhance performance of skeletal muscle.	CRTC3 CRTC2	7.86e-06	2	98	2	24674967
Pubmed	Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases.	PCSK5 PCSK6	7.86e-06	2	98	2	18061232
Pubmed	CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis.	CRTC3 CRTC2	7.86e-06	2	98	2	29078378
Pubmed	Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease.	PCSK5 PCSK6	7.86e-06	2	98	2	8335106
Pubmed	Functional pseudogenes inhibit the superoxide production.	NCF1C NCF1B	7.86e-06	2	98	2	26086043
Pubmed	Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4.	PCSK5 PCSK6	7.86e-06	2	98	2	8468318
Pubmed	Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.	PCSK5 LEFTY2 PCSK6	1.18e-05	16	98	3	20876279
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF460 ZNF629 ZKSCAN2 KIF7 TBC1D10B OSM ZNF526 WIZ VANGL1 PCSK6 ZNF281 TP73 ZNF574	1.54e-05	1116	98	13	31753913
Pubmed	Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia.	NCF1C NCF1B	2.35e-05	3	98	2	18036262
Pubmed	Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice.	NCF1C NCF1B	2.35e-05	3	98	2	10678931
Pubmed	Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome.	NCF1C NCF1B	2.35e-05	3	98	2	27044504
Pubmed	Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species.	NCF1C NCF1B	2.35e-05	3	98	2	17167081
Pubmed	Mice lacking NCF1 exhibit reduced growth of implanted melanoma and carcinoma tumors.	NCF1C NCF1B	2.35e-05	3	98	2	24358335
Pubmed	Molecular characterization of the mouse p47-phox (Ncf1) gene and comparative analysis of the mouse p47-phox (Ncf1) gene to the human NCF1 gene.	NCF1C NCF1B	2.35e-05	3	98	2	10891396
Pubmed	P47phox-/- mice are compromised in expansion and activation of CD8+ T cells and susceptible to Trypanosoma cruzi infection.	NCF1C NCF1B	2.35e-05	3	98	2	25474113
Pubmed	NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury.	NCF1C NCF1B	2.35e-05	3	98	2	18787174
Pubmed	NAD(P)H oxidase subunit p47phox is elevated, and p47phox knockout prevents diaphragm contractile dysfunction in heart failure.	NCF1C NCF1B	2.35e-05	3	98	2	26209274
Pubmed	Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.	NCF1C NCF1B	2.35e-05	3	98	2	24873968
Pubmed	p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice.	NCF1C NCF1B	2.35e-05	3	98	2	22184329
Pubmed	NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.	NCF1C NCF1B	2.35e-05	3	98	2	11018074
Pubmed	Natural Loss-of-Function Mutations in Qa2 and NCF1 Cause the Spread of Mannan-Induced Psoriasis.	NCF1C NCF1B	2.35e-05	3	98	2	33545139
Pubmed	Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.	NCF1C NCF1B	2.35e-05	3	98	2	20142487
Pubmed	Enhanced host defense after gene transfer in the murine p47phox-deficient model of chronic granulomatous disease.	NCF1C NCF1B	2.35e-05	3	98	2	9116268
Pubmed	Mice producing less reactive oxygen species are relatively resistant to collagen glycopeptide vaccination against arthritis.	NCF1C NCF1B	2.35e-05	3	98	2	20686129
Pubmed	Angiotensin II induced catabolic effect and muscle atrophy are redox dependent.	NCF1C NCF1B	2.35e-05	3	98	2	21570954
Pubmed	p47(phox) contributes to albuminuria and kidney fibrosis in mice.	NCF1C NCF1B	2.35e-05	3	98	2	25565313
Pubmed	Knockout of neutrophil cytosolic factor 1 ameliorates neuroinflammation and motor deficit after traumatic brain injury.	NCF1C NCF1B	2.35e-05	3	98	2	39357591
Pubmed	Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion.	NCF1C NCF1B	2.35e-05	3	98	2	12958309
Pubmed	Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells.	NCF1C NCF1B	2.35e-05	3	98	2	11435342
Pubmed	Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.	NCF1C NCF1B	2.35e-05	3	98	2	31118934
Pubmed	Female mice lacking p47phox have altered adipose tissue gene expression and are protected against high fat-induced obesity.	NCF1C NCF1B	2.35e-05	3	98	2	23482812
Pubmed	Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice.	NCF1C NCF1B	2.35e-05	3	98	2	16041040
Pubmed	The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs.	NCF1C NCF1B	2.35e-05	3	98	2	10085000
Pubmed	Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators.	NCF1C NCF1B	2.35e-05	3	98	2	10987289
Pubmed	Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae.	NCF1C NCF1B	2.35e-05	3	98	2	21435178
Pubmed	Intermittent hypoxia has organ-specific effects on oxidative stress.	NCF1C NCF1B	2.35e-05	3	98	2	18703411
Pubmed	Mycobacterial infection induces higher interleukin-1β and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase.	NCF1C NCF1B	2.35e-05	3	98	2	29228045
Pubmed	Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion.	NCF1C NCF1B	2.35e-05	3	98	2	17307863
Pubmed	Generation of reactive oxygen species (ROS) is a key factor for stimulation of macrophage proliferation by ceramide 1-phosphate.	NCF1C NCF1B	2.35e-05	3	98	2	22155727
Pubmed	Ncf1 affects osteoclast formation but is not critical for postmenopausal bone loss.	NCF1C NCF1B	2.35e-05	3	98	2	27829407
Pubmed	Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction.	NCF1C NCF1B	2.35e-05	3	98	2	24576409
Pubmed	The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis.	NCF1C NCF1B	2.35e-05	3	98	2	22376231
Pubmed	Leishmania amazonensis amastigotes trigger neutrophil activation but resist neutrophil microbicidal mechanisms.	NCF1C NCF1B	2.35e-05	3	98	2	23918780
Pubmed	NADPH oxidase NOX2 mediates TLR2/6-dependent release of GM-CSF from endothelial cells.	NCF1C NCF1B	2.35e-05	3	98	2	28274989
Pubmed	The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues.	NCF1C NCF1B	2.35e-05	3	98	2	26645958
Pubmed	Decidual differentiation of stromal cells promotes Proprotein Convertase 5/6 expression and lefty processing.	PCSK5 LEFTY2	2.35e-05	3	98	2	16141390
Pubmed	Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.	NCF1C NCF1B	2.35e-05	3	98	2	12364355
Pubmed	Activation of the adipocyte CREB/CRTC pathway in obesity.	CRTC3 CRTC2	2.35e-05	3	98	2	34686752
Pubmed	NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis.	NCF1C NCF1B	2.35e-05	3	98	2	24549323
Pubmed	NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities.	NCF1C NCF1B	2.35e-05	3	98	2	34557202
Pubmed	Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.	NCF1C NCF1B	2.35e-05	3	98	2	28467721
Pubmed	P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+.	NCF1C NCF1B	2.35e-05	3	98	2	10670582
Pubmed	NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.	NCF1C NCF1B	2.35e-05	3	98	2	20881184
Pubmed	Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.	NCF1C NCF1B	2.35e-05	3	98	2	26528554
Pubmed	The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis.	NCF1C NCF1B	2.35e-05	3	98	2	19052348
Pubmed	Effect of early particulate air pollution exposure on obesity in mice: role of p47phox.	NCF1C NCF1B	2.35e-05	3	98	2	20864666
Pubmed	Reactive oxygen species delay control of lymphocytic choriomeningitis virus.	NCF1C NCF1B	2.35e-05	3	98	2	23328631
Pubmed	p47phox-Dependent Oxidant Signalling through ASK1, MKK3/6 and MAPKs in Angiotensin II-Induced Cardiac Hypertrophy and Apoptosis.	NCF1C NCF1B	2.35e-05	3	98	2	34572995
Pubmed	Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice.	NCF1C NCF1B	2.35e-05	3	98	2	17114280
Pubmed	Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury.	NCF1C NCF1B	2.35e-05	3	98	2	19168575
Pubmed	B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production.	NCF1C NCF1B	2.35e-05	3	98	2	25989352
Pubmed	NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.	NCF1C NCF1B	2.35e-05	3	98	2	19503084
Pubmed	Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.	NCF1C NCF1B	2.35e-05	3	98	2	17404617
Pubmed	Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction.	NCF1C NCF1B	2.35e-05	3	98	2	17332431
Pubmed	Lpp of Escherichia coli K1 inhibits host ROS production to counteract neutrophil-mediated elimination.	NCF1C NCF1B	2.35e-05	3	98	2	36592568
Pubmed	Genetic requirement of p47phox for superoxide production by murine microglia.	NCF1C NCF1B	2.35e-05	3	98	2	11156938
Pubmed	Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression.	NCF1C NCF1B	2.35e-05	3	98	2	30504842
Pubmed	Genomic structure of the human p47-phox (NCF1) gene.	NCF1C NCF1B	2.35e-05	3	98	2	10772875
Pubmed	A Feed-Forward Mechanism Involving the NOX Complex and RyR-Mediated Ca2+ Release During Axonal Specification.	NCF1C NCF1B	2.35e-05	3	98	2	27798190
Pubmed	Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases.	PCSK5 PCSK6	2.35e-05	3	98	2	8670066
Pubmed	Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived reactive oxygen species.	NCF1C NCF1B	2.35e-05	3	98	2	20702812
Pubmed	Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism.	NCF1C NCF1B	2.35e-05	3	98	2	33705493
Pubmed	Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis.	NCF1C NCF1B	2.35e-05	3	98	2	23965970
Pubmed	CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1.	DIP2A DIP2C	2.35e-05	3	98	2	17236128
Pubmed	Macrophage-derived reactive oxygen species protects against autoimmune priming with a defined polymeric adjuvant.	NCF1C NCF1B	2.35e-05	3	98	2	26455429
Pubmed	Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice.	NCF1C NCF1B	2.35e-05	3	98	2	15513930
Pubmed	Conditional haploinsufficiency of NCF1 (encoding p47(phox)), a signaling gene with a heterozygous phenotype potentially subject to natural selection.	NCF1C NCF1B	2.35e-05	3	98	2	15626477
Pubmed	Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt.	NCF1C NCF1B	2.35e-05	3	98	2	15033459
Pubmed	NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity.	NCF1C NCF1B	2.35e-05	3	98	2	19077231
Pubmed	Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles.	NCF1C NCF1B	2.35e-05	3	98	2	20828610
Pubmed	p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation.	NCF1C NCF1B	2.35e-05	3	98	2	20817944
Pubmed	Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.	NCF1C NCF1B	2.35e-05	3	98	2	22319452
Pubmed	Early determinants of H2O2-induced endothelial dysfunction.	NCF1C NCF1B	2.35e-05	3	98	2	16895801
Pubmed	Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis.	NCF1C NCF1B	2.35e-05	3	98	2	20690191
Pubmed	Endosomal acidification and activation of NADPH oxidase isoforms are upstream events in hyperosmolarity-induced hepatocyte apoptosis.	NCF1C NCF1B	2.35e-05	3	98	2	16772302
Pubmed	Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice.	NCF1C NCF1B	2.35e-05	3	98	2	32504071
Pubmed	Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells.	NCF1C NCF1B	2.35e-05	3	98	2	16280459
Pubmed	TORC2/3-mediated DUSP1 upregulation is essential for human decidualization.	CRTC3 CRTC2	2.35e-05	3	98	2	33780908
Pubmed	Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.	NCF1C NCF1B	2.35e-05	3	98	2	18185592
Pubmed	NCF1-dependent production of ROS protects against lupus by regulating plasmacytoid dendritic cell development and functions.	NCF1C NCF1B	2.35e-05	3	98	2	36853827
Pubmed	Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation.	NCF1C NCF1B	2.35e-05	3	98	2	23024271
Pubmed	Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells.	NCF1C NCF1B	2.35e-05	3	98	2	21253614
Pubmed	Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2.	NCF1C NCF1B	2.35e-05	3	98	2	25873172
Pubmed	Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene.	NCF1C NCF1B	2.35e-05	3	98	2	15310853
Pubmed	Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21.	NCF1C NCF1B	2.35e-05	3	98	2	31393787
Pubmed	Vascular effects following homozygous disruption of p47(phox) : An essential component of NADPH oxidase.	NCF1C NCF1B	2.35e-05	3	98	2	10725280
Pubmed	Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice.	NCF1C NCF1B	2.35e-05	3	98	2	34970267
Pubmed	Germ-free mice deficient of reactive oxygen species have increased arthritis susceptibility.	NCF1C NCF1B	2.35e-05	3	98	2	25689796
Interaction	GPR156 interactions	SLC4A7 ZNF460 VANGL1 RPUSD2 ZNF574	1.73e-05	71	91	5	int:GPR156
Interaction	NOTCH2 interactions	ZNF672 ZNF628 ZNF460 ZKSCAN8 ZNF629 ZKSCAN2 ZNF623 ZNF783 ZNF526 ZNF574	2.11e-05	423	91	10	int:NOTCH2
Cytoband	19q13.43	ZNF671 ZNF551 ZSCAN5B ZNF530 ZNF256 ZNF814 ZNF548	8.25e-10	87	98	7	19q13.43
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	CA11 ZNF671 ZNF628 ZNF460 RELB ZNF416 ZNF551 ZSCAN5B ZNF526 ZNF530 MZF1 ZNF256 ZNF814 ZNF548 SBK2 ZNF574	4.98e-09	1192	98	16	chr19q13
Cytoband	17q21.3	PRAC2 ADAM11	5.31e-04	16	98	2	17q21.3
Cytoband	19q13.4	ZNF460 ZNF416 MZF1	6.63e-04	79	98	3	19q13.4
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF671 ZNF672 HIVEP1 ZNF628 ZNF157 ZNF165 ZNF460 ZKSCAN8 ZNF629 ZKSCAN2 ZNF236 ZNF623 ZNF416 ZNF783 ZNF441 ZNF551 ZSCAN5B ZNF526 GZF1 WIZ ZNF530 MZF1 ZNF648 ZNF256 ZNF814 ZNF782 ZNF439 ZNF281 ZNF548 ZNF574	2.20e-24	718	68	30	28
GeneFamily	Proprotein convertase subtilisin/kexin family	PCSK5 PCSK6	4.93e-04	9	68	2	973
Coexpression	GSE21670_TGFB_VS_IL6_TREATED_STAT3_KO_CD4_TCELL_UP	DLGAP2 CRTC3 HECTD4 ZNF623 ZSCAN5B NALCN ZNF281	8.81e-06	199	96	7	M7448
ToppCell	LA-14._Fibroblast_III\|LA / Chamber and Cluster_Paper	PCSK5 LAMA2 YBX3 RELB SNED1 PCSK6	4.37e-06	193	98	6	7426c291bac59e539c427bcaae18abc7d397d44e
ToppCell	Parenchymal-10x5prime-Stromal-Peri/Epineurial_\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CA11 ZNF629 LAMA2 KIF7 SNED1 ANGPTL7	5.36e-06	200	98	6	4c3c11dd5e71ebc3d62264eeaeb71a850b149779
Disease	Caudal Dysgenesis Syndrome	PCSK5 VANGL1	9.41e-06	2	91	2	C1838569
Disease	Sacral defect and anterior sacral meningocele	PCSK5 VANGL1	9.41e-06	2	91	2	C1838568
Disease	Lumbosacral agenesis	PCSK5 VANGL1	9.41e-06	2	91	2	C0431415
Disease	chronic granulomatous disease (implicated_via_orthology)	NCF1C NCF1B	9.35e-05	5	91	2	DOID:3265 (implicated_via_orthology)
Disease	Sacral agenesis	PCSK5 VANGL1	1.96e-04	7	91	2	C0344490
Disease	rheumatoid arthritis (implicated_via_orthology)	NCF1C NCF1B	6.08e-04	12	91	2	DOID:7148 (implicated_via_orthology)
Disease	anemia (implicated_via_orthology)	SLC4A7 SLC4A3	9.62e-04	15	91	2	DOID:2355 (implicated_via_orthology)
Disease	electrocardiography	HIVEP1 ADAM11 SLC4A3 TBC1D10B SVIL KCNN3 KCNQ1	1.28e-03	530	91	7	EFO_0004327
Disease	Headache, type 2 diabetes mellitus	PCSK6 KCNQ1	2.28e-03	23	91	2	HP_0002315, MONDO_0005148

Protein segments in the cluster

Peptide	Gene	Start	Entry
QVRHVGRTVRGHPRK	TMEM184C	346	Q9NVA4
HRQGERTRERHKSPR	VANGL1	21	Q8TAA9
REELGQQHPRHSRPR	CEP295NL	181	Q96MC4
SHRLEDNPGVRRHLV	SLC4A3	271	P48751
QRLLSHPRQRTDSRH	C1orf167	601	Q5SNV9
HPRQRTDSRHERVQI	C1orf167	606	Q5SNV9
ALQRHRRIHTGERPF	GZF1	561	Q9H116
LRRKRQVRRGHPTVH	ADAM11	221	O75078
LVRQDSRHQRIRLPH	APTX	21	Q7Z2E3
HRTVGTQRRLERHPI	C13orf42	231	A0A1B0GVH6
RPTLHSRHRELGERL	ARMC5	611	Q96C12
RSESPGRIRHLVHSV	DLGAP2	221	Q9P1A6
IRHRPHDQLRLRIGV	NPR2	946	P20594
EPLPHVHRESRARRS	ATP8B3	1236	O60423
HRALRGNRDPRHPER	CA11	296	O75493
HVARLVRVLARPRQH	DNHD1	2871	Q96M86
PGRIRHLVHSVQRLF	DLGAP4	136	Q9Y2H0
HHQRRRRAVPVSEVE	ADAMTS16	81	Q8TE57
GICRVRLRPHVSPRH	RELB	206	Q01201
NEHIHRLSRQPTRLR	ANGPTL7	206	O43827
VPHRIHSTSRNVREE	MAP4K3	311	Q8IVH8
TRRPVLARTHVQGRV	KCNQ1	96	P51787
HGPIRTALERRLHNQ	FANCF	51	Q9NPI8
ARHPQRLDRHGFVSR	HSPB2	101	Q16082
TSGRLHEEARRRLPH	GPR179	916	Q6PRD1
EHVVVRITITHPRRG	PCSK5	506	Q92824
HVVVRTSISHPRRGD	PCSK6	541	P29122
GGSRHRQASPLVHRR	KCNN3	151	Q9UGI6
PRHRSETRIIHRGRR	KIF7	376	Q2M1P5
IRGGTPTHARIIVRH	LAMA2	1276	P24043
RTVHTLEQRRHPAGL	HECTD4	2761	Q9Y4D8
TRHHNRVPREGRPEA	NEURL2	116	Q9BR09
LIPEGARHIRVEHRS	ADAMTSL5	221	Q6ZMM2
PRRSSIRNVHSIHQR	NCF1B	301	A6NI72
PRRSSIRNAHSIHQR	NCF1C	276	A8MVU1
VHFRVRHTITIPNRG	TP73	586	O15350
EVRQLRHLHRTRPPD	LINC00315	61	P59091
RSTRHHGLVERVQRD	CRTC2	96	Q53ET0
VRGTRHHGLVERPSR	CRTC3	86	Q6UUV7
VRGHLPSRRHQAIFT	GPR148	331	Q8TDV2
RHDRVRLVERGSPHS	DIP2C	1326	Q9Y2E4
HRHGRLSPRSAQARV	LEFTY2	131	O00292
RPILRRISHIGETVH	CCDC168	5331	Q8NDH2
RHDRVRLVERGSPHS	DIP2A	1341	Q14689
HPRRRSAVIAIREHL	SBK2	311	P0C263
RRVATDRRHLGHVQQ	PKN3	41	Q6P5Z2
VAHSRRGRLHLPRGR	IRS4	406	O14654
EVREHSVPLRRRHSE	FAM83G	621	A6ND36
RCRPLTGRTHQIRVH	RPUSD2	361	Q8IZ73
LINRIERATGQRPHH	WARS1	116	P23381
ERATGQRPHHFLRRG	WARS1	121	P23381
SRHGVRLHVTAAPRI	SIGLEC15	156	Q6ZMC9
GVHVPFSKESRRRHR	SLC4A7	46	Q9Y6M7
RRHVQTRLVEPRASA	SVIL	1451	O95425
AQHRRLVSHPRRSQE	RNF165	116	Q6ZSG1
LVSHPRRSQERVSVH	RNF165	121	Q6ZSG1
RRSQERVSVHPHRLH	RNF165	126	Q6ZSG1
SENRRVRIIAGRPIH	TENM1	1391	Q9UKZ4
EGSRRFLHHRGEPRL	WIZ	111	O95785
RHSPHQALRKGVRRT	OSM	221	P13725
RDRHGHRLVPSASVR	AARS2	51	Q5JTZ9
RHATVSGVRVSIRHP	SNED1	1031	Q8TER0
LVQRHLTPRTHGRIN	TNFAIP8L3	236	Q5GJ75
RQISGLIEHRRVHTG	ZNF671	351	Q8TAW3
NRRSPLTRHQRIHTA	ZNF460	486	Q14592
SSFRRHERIHTGERP	ZNF441	516	Q8N8Z8
RLIEHQRIHTGERPF	ZNF157	456	P51786
HVGQTFDRRSRVLPH	YBX3	241	P16989
IPDIRRSRHPHSLRT	SEMA4G	191	Q9NTN9
VAPRQQHGRTHPLRR	SSH2	1391	Q76I76
LELRRHQRAGHTIPR	SLC27A1	66	Q6PCB7
SDLRVHQRVHTGERP	ZSCAN5B	396	A6NJL1
TSLQVHRRIHTGERP	ZNF574	751	Q6ZN55
SLITHRRIHTGVRPH	ZNF256	281	Q9Y2P7
HARIHVSRSPTRPRV	ZNF672	181	Q499Z4
SDLIQHRRIHTGTRP	ZNF551	516	Q7Z340
RQRSGLIQHRRLHTG	ZNF551	541	Q7Z340
LRRHVLIHTGERPFQ	ZNF281	276	Q9Y2X9
GRRHRVLDPHTQLST	PRAC2	51	D3DTV9
RPSRRLHGSRAIHEE	TBC1D10B	631	Q4KMP7
GQRGRPHSRRRHRTT	PROP1	61	O75360
LVRHQRTHTGERPFE	ZNF416	481	Q9BWM5
DLTRHRRIHTGERPF	ZNF165	386	P49910
CRLIRHQRVHTGERP	ZNF548	406	Q8NEK5
RSRSLIRHQRIHTGE	ZKSCAN2	786	Q63HK3
QLTRHIRIHTGERPF	ZNF236	211	Q9UL36
QLERHSRIHTGERPF	ZNF236	1736	Q9UL36
RGTLQQHRRLHTGER	ZNF648	291	Q5T619
SRLVRHQRIHTGERP	ZNF648	461	Q5T619
RLSRHRRAVHGPPER	ZNF526	456	Q8TF50
HQVTPTIERPHSRIR	ZNF530	186	Q6P9A1
TIERPHSRIRHLRVP	ZNF530	191	Q6P9A1
SGLRNHRRTHTGERP	ZNF782	491	Q6ZMW2
QHRVIHERGKTPARR	ZNF629	531	Q9UEG4
DLIRHQRVHTRERPF	ZNF623	221	O75123
PGSRHRQKAVVRHTI	UNC13D	151	Q70J99
GLQRRPRHRIQSKHR	WASH6P	96	Q9NQA3
ERHVLGQPSRLVRQH	HIVEP1	1216	P15822
GTLILHQRVHPRERS	ZNF814	561	B7Z6K7
MSTIERHIRRRHPGS	ZFTA	451	C9JLR9
LGRPVSARVHGHRVL	ZKSCAN8	136	Q15776
SLPRRRLVLNHTRGV	TMEM249	106	Q2WGJ8
RRPSDLFRHQRIHTG	ZNF783	476	Q6ZMS7
SQLRIHRRIHTGEKP	ZNF439	451	Q8NDP4
LRQHQRVHTGERPFR	ZNF628	191	Q5EBL2
LRQHQRVHTGERPFR	ZNF628	581	Q5EBL2
RRERRSTVLGLPQHV	KIAA1522	156	Q9P206
VQHHIRQERRSLRHG	NALCN	756	Q8IZF0
SVLLQHRRVHSGERP	MZF1	526	P28698
LTQHRRIHTGERPFA	MZF1	556	P28698
ANLTQHRRIHTGERP	MZF1	666	P28698
RQRPTLTQHLRTHRR	MZF1	691	P28698