Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled opioid receptor activity

NPBWR1 OPRD1 OPRK1 OPRL1

6.48e-0871334GO:0004985
GeneOntologyMolecularFunctionneuropeptide binding

NPBWR1 OPRD1 OPRK1 OPRL1 GPR149

4.47e-06371335GO:0042923
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

NPC1 OR5T1 NPBWR1 GPR12 GPR21 PECAM1 GPR52 GPRC6A OR2T34 OPRD1 OPRK1 OPRL1 TLR10 OR2A12 NRXN3 NRXN2 P2RY2 P2RY4 OR51B6 GPR149 GPR75 OR10G8 PLXNA1

2.87e-05135313323GO:0004888
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

LARS1 SRGAP2 SIPA1 DOCK5 ARFGEF3 HPS4 THG1L NGEF SESN2 SIPA1L2 IQGAP3 USP6NL NCKAP1L

3.49e-0550713313GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

LARS1 SRGAP2 SIPA1 DOCK5 ARFGEF3 HPS4 THG1L NGEF SESN2 SIPA1L2 IQGAP3 USP6NL NCKAP1L

3.49e-0550713313GO:0030695
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR5T1 NPBWR1 GPR12 GPR21 GPR52 GPRC6A OR2T34 OPRD1 OPRK1 OPRL1 OR2A12 P2RY2 P2RY4 OR51B6 GPR149 GPR75 OR10G8

8.18e-0588413317GO:0004930
GeneOntologyMolecularFunctionG protein-coupled UTP receptor activity

P2RY2 P2RY4

1.32e-0431332GO:0045030
GeneOntologyMolecularFunctionG protein-coupled pyrimidinergic nucleotide receptor activity

P2RY2 P2RY4

2.62e-0441332GO:0071553
GeneOntologyMolecularFunctionneuroligin family protein binding

NRXN3 NRXN2

4.35e-0451332GO:0097109
GeneOntologyMolecularFunctionGTPase activator activity

LARS1 SRGAP2 SIPA1 DOCK5 SIPA1L2 IQGAP3 USP6NL NCKAP1L

5.71e-042791338GO:0005096
GeneOntologyMolecularFunctionGTPase binding

UNC13B BICD2 PLK2 SRGAP2 DOCK5 HPS4 NPC1L1 IQGAP3 USP6NL

6.98e-043601339GO:0051020
GeneOntologyMolecularFunctiondynein light intermediate chain binding

BICD2 DYNC2H1 DNAH17

8.38e-04281333GO:0051959
GeneOntologyMolecularFunctionL-leucine binding

UBR1 SESN2

9.05e-0471332GO:0070728
GeneOntologyMolecularFunctionsmall GTPase binding

UNC13B BICD2 SRGAP2 DOCK5 HPS4 NPC1L1 IQGAP3 USP6NL

1.41e-033211338GO:0031267
GeneOntologyBiologicalProcessG protein-coupled opioid receptor signaling pathway

NPBWR1 OPRD1 OPRK1 OPRL1

1.16e-06131344GO:0038003
GeneOntologyBiologicalProcessneuron cell-cell adhesion

NLGN3 NRXN3 NRXN2 TNR

2.92e-06161344GO:0007158
GeneOntologyBiologicalProcessnegative regulation of dendritic spine development

PLK2 NLGN3 SRGAP2C NGEF

4.86e-06181344GO:0061000
GeneOntologyBiologicalProcessextension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

SRGAP2 SRGAP2C

4.19e-0521342GO:0021816
GeneOntologyBiologicalProcessdense core granule docking

UNC13B UNC13A

4.19e-0521342GO:0061790
GeneOntologyBiologicalProcesscellular response to L-leucine

UBR1 LARS1 SESN2

7.31e-05131343GO:0071233
GeneOntologyCellularComponentsynaptic membrane

UNC13B SRGAP2 OPRD1 OPRK1 OPRL1 SLC12A5 NLGN3 NRXN3 PLPPR4 NRXN2 P2RY2 P2RY4 KCND2 UNC13A

2.54e-0558313514GO:0097060
GeneOntologyCellularComponentglutamatergic synapse

UNC13B SRGAP2 NLGN3 SRGAP2C NRXN3 PLPPR4 NRXN2 P2RY2 P2RY4 KCND2 NGEF SRGAP2B SIPA1L2 TNR UNC13A PLXNA1

7.69e-0581713516GO:0098978
GeneOntologyCellularComponentpresynaptic active zone

UNC13B NRXN3 NRXN2 P2RY2 P2RY4 UNC13A

3.12e-041411356GO:0048786
GeneOntologyCellularComponentpresynaptic membrane

UNC13B OPRD1 OPRK1 NRXN3 NRXN2 P2RY2 P2RY4 UNC13A

4.46e-042771358GO:0042734
DomainsrGAP2

SRGAP2 SRGAP2C SRGAP2B

3.37e-0731313IPR030252
DomainOpioid_rcpt

OPRD1 OPRK1 OPRL1

1.34e-0641313IPR001418
DomainSterol-sensing

NPC1 SCAP NPC1L1

3.34e-0651313PF12349
DomainGPCR_Rhodpsn_7TM

OR5T1 NPBWR1 GPR12 GPR21 GPR52 OR2T34 OPRD1 OPRK1 OPRL1 OR2A12 P2RY2 P2RY4 OR51B6 GPR149 GPR75 OR10G8

1.88e-0567013116IPR017452
Domain7tm_1

OR5T1 NPBWR1 GPR12 GPR21 GPR52 OR2T34 OPRD1 OPRK1 OPRL1 OR2A12 P2RY2 P2RY4 OR51B6 GPR149 GPR75 OR10G8

2.14e-0567713116PF00001
DomainG_PROTEIN_RECEP_F1_1

OR5T1 NPBWR1 GPR12 GPR21 GPR52 OR2T34 OPRD1 OPRK1 OPRL1 OR2A12 P2RY2 P2RY4 OR51B6 GPR149 GPR75 OR10G8

2.47e-0568513116PS00237
DomainG_PROTEIN_RECEP_F1_2

OR5T1 NPBWR1 GPR12 GPR21 GPR52 OR2T34 OPRD1 OPRK1 OPRL1 OR2A12 P2RY2 P2RY4 OR51B6 GPR149 GPR75 OR10G8

2.74e-0569113116PS50262
DomainGPCR_Rhodpsn

OR5T1 NPBWR1 GPR12 GPR21 GPR52 OR2T34 OPRD1 OPRK1 OPRL1 OR2A12 P2RY2 P2RY4 OR51B6 GPR149 GPR75 OR10G8

2.79e-0569213116IPR000276
DomainNPC1_N

NPC1 NPC1L1

4.88e-0521312IPR032190
DomainNP_C_type

NPC1 NPC1L1

4.88e-0521312IPR004765
DomainNPC1_N

NPC1 NPC1L1

4.88e-0521312PF16414
DomainSSD

NPC1 SCAP NPC1L1

9.16e-05131313IPR000731
DomainSSD

NPC1 SCAP NPC1L1

9.16e-05131313PS50156
DomainUnc-13

UNC13B UNC13A

1.46e-0431312IPR027080
Domain-

PLPPR3 DOLPP1 PLPPR4

2.55e-041813131.20.144.10
DomainacidPPc

PLPPR3 DOLPP1 PLPPR4

2.55e-04181313SM00014
DomainP_Acid_Pase_2/haloperoxidase

PLPPR3 DOLPP1 PLPPR4

3.52e-04201313IPR000326
DomainPAP2

PLPPR3 DOLPP1 PLPPR4

3.52e-04201313PF01569
DomainFCH

SRGAP2 SRGAP2C SRGAP2B

4.71e-04221313PF00611
DomainFCH

SRGAP2 SRGAP2C SRGAP2B

4.71e-04221313SM00055
DomainMunc13_dom-2

UNC13B UNC13A

4.82e-0451312IPR014772
DomainMHD2

UNC13B UNC13A

4.82e-0451312PS51259
DomainMunc13_subgr_dom-2

UNC13B UNC13A

4.82e-0451312IPR019558
DomainMembr_traf_MHD

UNC13B UNC13A

4.82e-0451312PF10540
DomainDUF1041

UNC13B UNC13A

4.82e-0451312SM01145
DomainFCH_dom

SRGAP2 SRGAP2C SRGAP2B

5.39e-04231313IPR001060
DomainF_BAR

SRGAP2 SRGAP2C SRGAP2B

6.93e-04251313IPR031160
DomainF_BAR

SRGAP2 SRGAP2C SRGAP2B

6.93e-04251313PS51741
DomainMunc13_1

UNC13B UNC13A

1.00e-0371312IPR014770
DomainMHD1

UNC13B UNC13A

1.00e-0371312PS51258
DomainSyndecan

NRXN3 NRXN2

1.00e-0371312PF01034
DomainZnF_UBR1

UBR1 UBR4

1.00e-0371312SM00396
DomainDUF1041

UNC13B UNC13A

1.00e-0371312PF06292
DomainCAPS_dom

UNC13B UNC13A

1.00e-0371312IPR010439
DomainZF_UBR

UBR1 UBR4

1.00e-0371312PS51157
Domainzf-UBR

UBR1 UBR4

1.00e-0371312PF02207
DomainZnf_UBR

UBR1 UBR4

1.00e-0371312IPR003126
DomainSyndecan/Neurexin_dom

NRXN3 NRXN2

1.00e-0371312IPR027789
Domain7TM_GPCR_Srsx

GPR12 OR2T34 OPRD1 OPRK1 OPRL1

1.16e-031121315SM01381
DomainPtc/Disp

NPC1 NPC1L1

1.70e-0391312IPR003392
DomainPatched

NPC1 NPC1L1

1.70e-0391312PF02460
DomainRap_GAP

SIPA1 SIPA1L2

2.12e-03101312PF02145
DomainRap_GAP_dom

SIPA1 SIPA1L2

2.58e-03111312IPR000331
DomainRAPGAP

SIPA1 SIPA1L2

2.58e-03111312PS50085
DomainNeurexin-like

NRXN3 NRXN2

4.20e-03141312IPR003585
Domain4.1m

NRXN3 NRXN2

4.20e-03141312SM00294
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

NPBWR1 GPR12 GPR21 GPR52 OPRD1 OPRK1 OPRL1 P2RY2 P2RY4 GPR75

2.18e-0526010410M39397
Pubmed

Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.

SRGAP2 SRGAP2C SRGAP2B

5.98e-083137322559944
Pubmed

Identification of a novel family of G protein-coupled receptor associated sorting proteins.

GPRASP1 OPRD1 OPRK1 OPRL1

2.24e-0714137415086532
Pubmed

Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication.

SRGAP2 SRGAP2C SRGAP2B

2.38e-074137322559943
Pubmed

Quantitative autoradiographic mapping of the ORL1, mu-, delta- and kappa-receptors in the brains of knockout mice lacking the ORL1 receptor gene.

OPRD1 OPRK1 OPRL1

2.38e-074137311430857
Pubmed

Multiple opioid receptor-like genes are identified in diverse vertebrate phyla.

OPRD1 OPRK1 OPRL1

2.38e-07413738941707
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NPC1 UNC13B TEAD2 SLC35B3 UBR4 TMC6 HECTD4 ST3GAL1 SRGAP2 LRRK1 ATP13A2 GBA2 SCAP ZBED4 PIGW SIPA1L2 IQGAP3 PLXNA1

3.78e-0711051371835748872
Pubmed

Ltbp4 regulates Pdgfrβ expression via TGFβ-dependent modulation of Nrf2 transcription factor function.

TGFB1 NFE2L2 SESN2

5.95e-075137327645114
Pubmed

Structures, alternative splicing, and neurexin binding of multiple neuroligins.

NLGN3 NRXN3 NRXN2

1.19e-06613738576240
Pubmed

Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy.

P2RY2 P2RY4 KCND2

2.07e-067137325003238
Pubmed

Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.

NLGN3 NRXN3 NRXN2

3.30e-068137330871858
Pubmed

Molecular self-avoidance in synaptic neurexin complexes.

NLGN3 NRXN3 NRXN2

4.94e-069137334919427
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

CDS1 MYT1 TMC6 HECTD4 PAQR5 ST3GAL1 SRGAP2 IDE PTPN18 NEK9 OPRL1 DOCK5 ARFGEF3 NLGN3 PPP2R3A NGEF TMEM143 CATSPERG CNOT1

6.41e-0614891371928611215
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

GPRASP1 HECW1 UBR4 HECTD4 SRGAP2 SIPA1 NEK9 SLC12A5 NLGN3 PLPPR4 NGEF TNR TNS1 CNOT1 UNC13A

6.50e-069631371528671696
Pubmed

SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.

NLGN3 NRXN3 NRXN2

9.64e-0611137332973045
Pubmed

Distribution of P2Y receptor subtypes on haematopoietic cells.

P2RY2 P2RY4

1.54e-05213729535005
Pubmed

Structure and chromosomal mapping of genes for the mouse kappa-opioid receptor and an opioid receptor homologue (MOR-C).

OPRK1 OPRL1

1.54e-05213727802669
Pubmed

K+ secretion activated by luminal P2Y2 and P2Y4 receptors in mouse colon.

P2RY2 P2RY4

1.54e-052137215718265
Pubmed

Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction.

NFE2L2 SESN2

1.54e-052137232407927
Pubmed

TGFβ1 mediates alcohol-induced Nrf2 suppression in lung fibroblasts.

TGFB1 NFE2L2

1.54e-052137225421510
Pubmed

Extracellular ATP activates MAP kinase cascades through a P2Y purinergic receptor in the human intestinal Caco-2 cell line.

P2RY2 P2RY4

1.54e-052137219836435
Pubmed

Regulation of insulin exocytosis by Munc13-1.

UNC13B UNC13A

1.54e-052137212871971
Pubmed

Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity.

UNC13B UNC13A

1.54e-052137217561838
Pubmed

Exercise ameliorates chronic inflammatory response induced by high-fat diet via Sestrin2 in an Nrf2-dependent manner.

NFE2L2 SESN2

1.54e-052137237336368
Pubmed

Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.

OPRD1 OPRK1

1.54e-05213728393575
Pubmed

Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.

UNC13B UNC13A

1.54e-052137228489077
Pubmed

μ-Opioid receptor antibody reveals tissue-dependent specific staining and increased neuronal μ-receptor immunoreactivity at the injured nerve trunk in mice.

OPRD1 OPRK1

1.54e-052137224278116
Pubmed

SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses.

SRGAP2 SRGAP2C

1.54e-052137227373832
Pubmed

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles.

UNC13B UNC13A

1.54e-052137210440375
Pubmed

Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin.

UNC13B UNC13A

1.54e-052137222066784
Pubmed

The Crosstalk between Nrf2 and TGF-β1 in the Epithelial-Mesenchymal Transition of Pancreatic Duct Epithelial Cells.

TGFB1 NFE2L2

1.54e-052137226226105
Pubmed

Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.

UNC13B UNC13A

1.54e-052137232187536
Pubmed

Regulations of opioid dependence by opioid receptor types.

OPRD1 OPRK1

1.54e-052137211316510
Pubmed

Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice.

NPC1 GBA2

1.54e-052137226275242
Pubmed

Prenatal exposure to valproic acid leads to reduced expression of synaptic adhesion molecule neuroligin 3 in mice.

NLGN3 NRXN3

1.54e-052137219607885
Pubmed

Role of mammalian homologue of Caenorhabditis elegans unc-13-1 (Munc13-1) in the recruitment of newcomer insulin granules in both first and second phases of glucose-stimulated insulin secretion in mouse islets.

UNC13B UNC13A

1.54e-052137222814762
Pubmed

Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.

UNC13B UNC13A

1.54e-052137228426965
Pubmed

The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk.

OPRD1 OPRK1

1.54e-052137217622222
Pubmed

Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling.

UNC13B UNC13A

1.54e-052137223770256
Pubmed

ATP modulates transcription factors through P2Y2 and P2Y4 receptors via PKC/MAPKs and PKC/Src pathways in MCF-7 cells.

P2RY2 P2RY4

1.54e-052137219900397
Pubmed

The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1.

TGFB1 NFE2L2

1.54e-052137226915435
Pubmed

Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene.

NPC1 RMC1

1.54e-05213729211850
Pubmed

The histone demethylase PHF8 regulates TGFβ signaling and promotes melanoma metastasis.

PHF8 TGFB1

1.54e-052137235179962
Pubmed

Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses.

UNC13B UNC13A

1.54e-052137231851910
Pubmed

Human NPC1L1 and NPC1 can functionally substitute for the ncr genes to promote reproductive development in C. elegans.

NPC1 NPC1L1

1.54e-052137217662536
Pubmed

Differential control of vesicle priming and short-term plasticity by Munc13 isoforms.

UNC13B UNC13A

1.54e-052137211832228
Pubmed

Munc13 controls the location and efficiency of dense-core vesicle release in neurons.

UNC13B UNC13A

1.54e-052137223229896
Pubmed

Nrf2-ARE pathway regulates induction of Sestrin-2 expression.

NFE2L2 SESN2

1.54e-052137222749810
Pubmed

The seventh transmembrane domains of the delta and kappa opioid receptors have different accessibility patterns and interhelical interactions.

OPRD1 OPRK1

1.54e-052137216331961
Pubmed

Sialyltransferase ST3GAL1 promotes cell migration, invasion, and TGF-β1-induced EMT and confers paclitaxel resistance in ovarian cancer.

ST3GAL1 TGFB1

1.54e-052137230375371
Pubmed

Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming.

UNC13B UNC13A

1.54e-052137212070347
Pubmed

The adhesion molecule PECAM-1 enhances the TGF-β-mediated inhibition of T cell function.

PECAM1 TGFB1

1.54e-052137226956486
Pubmed

Presynaptic impairment in Niemann-Pick C1-deficient neurons: not dependent on presence of glial cells.

NPC1 NPC1L1

1.54e-052137221507342
Pubmed

Identification of kappa- and delta-opioid receptor transcripts in immune cells.

OPRD1 OPRK1

1.54e-05213727649271
Pubmed

Munc13 genotype regulates secretory amyloid precursor protein processing via postsynaptic glutamate receptors.

UNC13B UNC13A

1.54e-052137223070049
Pubmed

Transforming growth factor-beta1 elicits Nrf2-mediated antioxidant responses in aortic smooth muscle cells.

TGFB1 NFE2L2

1.54e-052137219674192
Pubmed

Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist.

OPRD1 OPRK1

1.54e-052137224923251
Pubmed

The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A-dependent synaptic development.

SRGAP2C SRGAP2B

1.54e-052137231822692
Pubmed

Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite, galactosylated cholesterol.

NPC1 GBA2

1.54e-052137232144204
Pubmed

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling.

PECAM1 EPAS1

1.54e-052137210880563
Pubmed

Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.

UNC13B UNC13A

1.54e-052137228772123
Pubmed

G-protein-coupled receptor heterodimerization modulates receptor function.

OPRD1 OPRK1

1.54e-052137210385123
Pubmed

Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion.

UNC13B UNC13A

1.54e-052137217267576
Pubmed

Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor.

OPRD1 OPRL1

1.54e-05213729155012
Pubmed

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins.

NPC1 NPC1L1

1.54e-052137232410728
Pubmed

A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution.

UNC13B UNC13A

1.54e-052137235613050
Pubmed

Membrane bridging by Munc13-1 is crucial for neurotransmitter release.

UNC13B UNC13A

1.54e-052137230816091
Pubmed

A common molecular basis for membrane docking and functional priming of synaptic vesicles.

UNC13B UNC13A

1.54e-052137219558619
Pubmed

Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis.

NPBWR1 EPHX3

1.54e-052137217437806
Pubmed

Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase C.

UNC13B UNC13A

1.54e-052137218701688
Pubmed

A novel mechanism for cytoprotection against hypoxic injury: δ-opioid receptor-mediated increase in Nrf2 translocation.

OPRD1 NFE2L2

1.54e-052137225439010
Pubmed

Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice.

OPRD1 OPRK1

1.54e-052137216712978
Pubmed

Generation and function of astroglial lipoproteins from Niemann-Pick type C1-deficient mice.

NPC1 NPC1L1

1.54e-052137215544574
Pubmed

Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs.

UNC13B UNC13A

1.54e-052137211792326
Pubmed

NRF2-HIF2α Signaling Attenuates Endothelial Cell Senescence and Maintains Intercellular Junctions in Diabetes.

NFE2L2 EPAS1

1.54e-052137239113713
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

HECW1 DYNC2H1 ENPP4 GBA2 NEK9 THOC5 NLGN3 SCAP ARID2 DNAH17

2.76e-054931371015368895
Pubmed

Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm.

PECAM1 TGFB1 SLC20A1

3.90e-0517137325138534
Pubmed

Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+ Influx.

NRXN3 NRXN2

4.61e-053137238891114
Pubmed

Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.

TGFB1 SESN2

4.61e-053137220106877
Pubmed

Scanning of five chromosomes for alcohol consumption loci.

OPRK1 OPRL1

4.61e-053137211109025
Pubmed

Bardoxolone ameliorates TGF-β1-associated renal fibrosis through Nrf2/Smad7 elevation.

TGFB1 NFE2L2

4.61e-053137231059771
Pubmed

Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice.

OPRD1 OPRK1

4.61e-053137210082819
Pubmed

Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway after intestinal ischemia-reperfusion.

NFE2L2 SESN2

4.61e-053137238331008
Pubmed

miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression.

TGFB1 ARID2

4.61e-053137226169693
Pubmed

Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers.

OPRD1 OPRK1

4.61e-053137218537939
Pubmed

Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones.

OPRD1 OPRK1

4.61e-053137212603260
Pubmed

alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction.

NRXN3 NRXN2

4.61e-053137216406382
Pubmed

Deregulation of the phosphatidylinositol-3 kinase signaling cascade is associated with neurodegeneration in Npc1-/- mouse brain.

NPC1 NPC1L1

4.61e-053137216192643
Pubmed

No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse.

OPRD1 OPRK1

4.61e-053137215178356
Pubmed

Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses.

NRXN3 NRXN2

4.61e-053137231005376
Pubmed

Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder.

P2RY2 P2RY4

4.61e-053137211259526
Pubmed

Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.

OPRD1 OPRK1

4.61e-05313728114680
Pubmed

Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice.

OPRD1 OPRK1

4.61e-053137211032994
Pubmed

Loss of nucleotide regulation of epithelial chloride transport in the jejunum of P2Y4-null mice.

P2RY2 P2RY4

4.61e-053137212644577
Pubmed

Systemic morphine treatment derails normal uterine receptivity, leading to embryo implantation failure in mice.

OPRD1 OPRK1

4.61e-053137225855262
Pubmed

Opioid receptors: from binding sites to visible molecules in vivo.

OPRD1 OPRK1

4.61e-053137218718480
Pubmed

TGF-β and Hypoxia/Reoxygenation Promote Radioresistance of A549 Lung Cancer Cells through Activation of Nrf2 and EGFR.

TGFB1 NFE2L2

4.61e-053137226904167
Pubmed

Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.

UNC13B UNC13A

4.61e-053137233105896
Pubmed

Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.

NRXN3 NRXN2

4.61e-053137226446217
Pubmed

Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.

NRXN3 NRXN2

4.61e-053137211944992
Pubmed

Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations.

OPRD1 OPRK1

4.61e-053137218213616
GeneFamilyOpioid receptors

OPRD1 OPRK1 OPRL1

5.96e-074973245
GeneFamilyG protein-coupled receptors, Class A orphans

GPR12 GPR21 GPR52 GPR149 GPR75

6.21e-0578975262
GeneFamilyUNC13 homologs

UNC13B UNC13A

1.70e-044972836
GeneFamilyRho GTPase activating proteins|F-BAR domain containing

SRGAP2 SRGAP2C SRGAP2B

2.45e-04239731288
GeneFamilyPhospholipid phosphatase related

PLPPR3 PLPPR4

2.82e-0459721127
GeneFamilyUbiquitin protein ligase E3 component n-recognins

UBR1 UBR4

5.88e-047972785
GeneFamilyPurinergic receptors P2Y

P2RY2 P2RY4

1.25e-0310972213
CoexpressionAtlasDevelopingKidney_e15.5_Endothelial cells_emap-29977_top-relative-expression-ranked_500

KLHL6 PLK2 PECAM1 TMC6 CPA3 SRGAP2 SIPA1 PTPN18 TGFB1 EPAS1 PLD4 NCKAP1L

3.72e-0638412812DevelopingKidney_e15.5_Endothelial cells_emap-29977_500
CoexpressionAtlasDevelopingKidney_e15.5_Endothelial cells_emap-29977_k-means-cluster#5_top-relative-expression-ranked_1000

KLHL6 PLK2 GPR12 CPA3 SRGAP2 SIPA1 TGFB1 NFE2L2 RMC1 EPAS1 PLD4 NCKAP1L

1.17e-0543012812DevelopingKidney_e15.5_Endothelial cells_emap-29977_k5_1000
CoexpressionAtlasDevelopingKidney_e15.5_Endothelial cells_emap-29977_top-relative-expression-ranked_1000

KLHL6 PLK2 GPR12 PECAM1 TMC6 CPA3 SRGAP2 SIPA1 PTPN18 SLC12A5 TGFB1 NFE2L2 RMC1 EPAS1 PLD4 NCKAP1L

1.47e-0576412816DevelopingKidney_e15.5_Endothelial cells_emap-29977_1000
CoexpressionAtlasDevelopingKidney_e15.5_Endothelial cells_emap-29977_k-means-cluster#5_top-relative-expression-ranked_500

KLHL6 PLK2 CPA3 SRGAP2 SIPA1 PTPN18 TGFB1 PLD4

2.27e-051931288DevelopingKidney_e15.5_Endothelial cells_emap-29977_k5_500
ToppCellFetal_29-31_weeks-Immune-dendritic_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

KLHL6 LRRK1 TASL TLR10 SLC20A1 PLD4 NCKAP1L

1.30e-061771377c5e829bc4594761666d65cace5a9c5d19c16f187
ToppCellGlobus_pallidus-Neuronal|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

GPRASP1 GPR12 HECW1 SLC12A5 ARFGEF3 NRXN3 UNC13A

2.08e-061901377416de85d8841dac883faa6f5339b2fb461a09e82
ToppCellEntopeduncular-Neuronal|Entopeduncular / BrainAtlas - Mouse McCarroll V32

HECW1 OPRL1 SLC12A5 ARFGEF3 NRXN3 PLPPR4 UNC13A

2.23e-0619213774c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / Treatment groups by lineage, cell group, cell type

UNC13B CDS1 ST3GAL1 ARFGEF3 NRXN3 P3H2 ELF3

2.64e-0619713771a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KLHL6 SRGAP2 SIPA1 TLR10 SRGAP2C SRGAP2B NCKAP1L

2.82e-061991377744b63fba33b176ab7dde11646ccb313665505f7
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 LRRK1 TLR10 NLGN3 IQGAP3 NCKAP1L

6.60e-06148137612fa2c4922f03803006c606b1b16e79441e3bb13
ToppCellP15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NPC1 CDS1 PAQR5 GPRC6A DOCK5 ELF3

1.31e-0516713765c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SRGAP2 TLR10 SRGAP2C SRGAP2B PLD4 NCKAP1L

1.31e-051671376942134bbabe9972fae80cbc4ed4e94da52f55dc3
ToppCellE12.5-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KLHL6 PECAM1 SIPA1 PTPN18 TGFB1 EPAS1

1.55e-051721376ba99688e9f46671deccf824b1e77c6db0742d7df
ToppCellE12.5-Endothelial-proliferative_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KLHL6 PECAM1 SIPA1 PTPN18 TGFB1 EPAS1

1.55e-0517213762136170f6e1204734cec7dbf7b32e7d5179b92b5
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 PLPPR3 LRRK1 TLR10 NLGN3 NCKAP1L

1.55e-051721376f6b4754a7e4b3e38030316a0ae00d932bfa87e41
ToppCellLPS-IL1RA-Epithelial_alveolar-Mes-Like|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CDS1 NRXN3 P3H2 ELF3 IQGAP3

1.68e-051031375c11bb0238e81a42dad5d7687c9d22474129d803d
ToppCellfacs-Marrow-T_cells-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 PAQR5 SLC9A2 NRXN2 TNS1 PLD4

1.77e-05176137674f851a398c7562dd713bc0d8d488c0037243112
ToppCellfacs-Marrow-T_cells-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 PAQR5 SLC9A2 NRXN2 TNS1 PLD4

1.77e-05176137631b5459a978d5cdde0af03a77401e0464d8c95ba
ToppCelldroplet-Spleen-nan-24m-Myeloid-macrophage_dendritic_cell_progenitor|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDS1 PAQR5 GPR52 ATP13A2 NRXN2 TNS1

1.95e-051791376d50d29f26d5a2cd8c4cd4e1244e1bb8de072d159
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 PAQR5 ATP13A2 NRXN2 TNS1 PLD4

2.01e-051801376df60970520fba2ac0639faa54096766d07418ca4
ToppCell18-Airway-Immune-Hematopoietic,_B_Cells|Airway / Age, Tissue, Lineage and Cell class

PAQR5 CPA3 TASL TLR10 PLD4 NCKAP1L

2.01e-051801376200cecbd8c12a4ec334583fdd5057397504de71e
ToppCellwk_20-22-Hematologic-Myeloid-pDC|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

NPC1 LRRK1 ATP13A2 P3H2 SLC20A1 PLD4

2.07e-05181137660607c5ff6d5b1cb416adc034491dca31c41e988
ToppCellfacs-Marrow-B-cells-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 PAQR5 ATP13A2 NRXN2 TNS1 PLD4

2.07e-051811376782716b8b1d447d2bbe09a693fa5ed7ebeac0efb
ToppCellfacs-Marrow-B-cells-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 PAQR5 ATP13A2 NRXN2 TNS1 PLD4

2.07e-051811376e2481291c236105774c53883e6f20da11941df9b
ToppCell18-Distal-Immune-Hematopoietic,_B_Cells|Distal / Age, Tissue, Lineage and Cell class

KLHL6 CPA3 TASL TLR10 PLD4 NCKAP1L

2.14e-051821376cd0b9f0a25147ec3bc1e32d698511d1c3b33891f
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAQR5 ATP13A2 SLC9A2 NRXN2 TNS1 PLD4

2.14e-05182137633afbb7c4352b03266501b1f4f0e751c12c7350d
ToppCellIPF-Myeloid-DC_Langerhans|IPF / Disease state, Lineage and Cell class

LRRK1 TASL TLR10 DOCK5 P3H2 PLD4

2.34e-051851376f8ee3cb2aa9ec70f9ce8797be2b155da27ef6464
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 PAQR5 ATP13A2 NRXN2 TNS1 PLD4

2.34e-05185137665dcb0a7ee64990a34a87c167b44497107f035ee
ToppCellP28-Endothelial-capillary_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PLK2 PECAM1 SIPA1 ATP13A2 TGFB1 EPAS1

2.42e-05186137626a625ca0300055d6af3472aa0bfba59b73db292
ToppCellSubstantia_nigra-Neuronal|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

HECW1 OPRL1 SLC12A5 ARFGEF3 NRXN3 UNC13A

2.42e-0518613763f889083fcffe516388e9b03a5e23af2010ced33
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia-Micro_L1-6_C1QC|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SRGAP2 SIPA1 TLR10 SRGAP2B PLD4 NCKAP1L

2.49e-05187137617a37fc3a1d62fef3137e5ff26a84c0b8c80e124
ToppCellE12.5-Endothelial|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KLHL6 PECAM1 SIPA1 PTPN18 TGFB1 EPAS1

2.49e-051871376b8ed57b3c39ffbf750cd08a3e03ec11dae43d00e
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Micro|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SRGAP2 SIPA1 TLR10 SRGAP2B PLD4 NCKAP1L

2.49e-0518713761b0eb29394040555516677b9de75c15e769c4c53
ToppCellnormal_Lung-Myeloid_cells-pDCs|normal_Lung / Location, Cell class and cell subclass

SLC35B3 PHF8 NEK9 SCAP P3H2 PLD4

2.49e-051871376d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SRGAP2 SIPA1 TLR10 SRGAP2B PLD4 NCKAP1L

2.49e-05187137611c773cf3dc1e725b7e4d8edd676c8a94a231d2a
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_migrating_dendritic_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KLHL6 LRRK1 TASL TLR10 PLD4 NCKAP1L

2.57e-0518813768fc15c8b78fdd1a578e34325011bc5a87a8aab31
ToppCell10x5'-GI_small-bowel-Lymphocytic_B-Memory_B_cells|GI_small-bowel / Manually curated celltypes from each tissue

TEAD2 MYT1 TLR10 TNR USP6NL PLD4

2.57e-051881376ab1384e6f71053946368502282aeebf1ba92d33e
ToppCellSubstantia_nigra-Endothelial|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

TEAD2 LRRK1 TGFB1 TNS1 EPAS1 FOXF2

2.64e-051891376bef8234bd9c4d6e3cdef0791d8066b39ba56ebba
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

UNC13B OPRK1 ARFGEF3 NRXN3 P3H2 ELF3

2.64e-0518913767659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR12 GPR52 OPRK1 SLC12A5 PLPPR4 NGEF

2.72e-0519013761c5cf933ce71fed5638b9ef31eb81f6c2b6dadbc
ToppCellPCW_13-14-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

UNC13B ENPP4 GREB1L ARFGEF3 P3H2 ELF3

2.80e-05191137663aa671837b79d2feb7ed1e67712cc01caf72bef
ToppCellPCW_13-14-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CDS1 OPRK1 GREB1L ARFGEF3 P3H2 ELF3

2.97e-051931376b38aaffbea36ef6c08ebe82675438f873c89b242
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PECAM1 NRXN2 C1QTNF1 TNR TNS1 EPAS1

2.97e-0519313762483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 ST3GAL1 SRGAP2 TASL SRGAP2B NCKAP1L

2.97e-051931376bd08555f02db8bc903caacae57e80bb91e2556ce
ToppCellThalamus-Neuronal|Thalamus / BrainAtlas - Mouse McCarroll V32

GPRASP1 HECW1 OPRL1 SLC12A5 ARFGEF3 UNC13A

2.97e-051931376712a4acd1167e43543950bc819ff11984e6f718d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 ST3GAL1 SRGAP2 TASL SRGAP2B NCKAP1L

2.97e-051931376374d0526a071e973c3f43b4564f78f6933bb67ed
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

NPC1 UNC13B ARFGEF3 BTBD16 P3H2 ELF3

3.06e-05194137697534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

UNC13B OPRK1 GREB1L ARFGEF3 P3H2 ELF3

3.06e-051941376f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCellControl-Myeloid-ncMonocyte|Control / Disease state, Lineage and Cell class

SRGAP2 DOCK5 NBPF19 SRGAP2C P2RY2 SRGAP2B

3.15e-051951376fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ST3GAL1 TASL SRGAP2C NFE2L2 SRGAP2B PLD4

3.15e-051951376562e4c0e4e81f6303e57b846da71d1667fc35963
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SRGAP2 TLR10 SRGAP2C SRGAP2B USP6NL PLD4

3.15e-051951376c9469e2d31beb30ebb64b3f0a5239e23119fbaa5
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ST3GAL1 TASL SRGAP2C NFE2L2 SRGAP2B PLD4

3.15e-051951376fa8ac154e5aebc26463ff84f0ad1038095770bc6
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

UNC13B CDS1 ST3GAL1 NRXN3 P3H2 ELF3

3.33e-0519713761485933986921ff45669d9b7501c8d17050b3e97
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 SRGAP2 LRRK1 SRGAP2C SRGAP2B NCKAP1L

3.33e-051971376dea1d29154c585ab588e50b83c7c8de7fe24d2d4
ToppCellFrontal_cortex-Neuronal|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

GPRASP1 HECTD4 SLC12A5 NRXN3 PLPPR4 UNC13A

3.53e-051991376f88039d862f3bfa01dc39d2de4f3f548dc5a0e61
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Car3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NPBWR1 GPR52 OPRK1 NPC1L1 IQGAP3

5.93e-0513413754ef5f395e321cf04e56560be2502a8aa157682f4
ToppCellfacs-Aorta-Heart-3m-Mesenchymal-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDHA8 GPRC6A PGAP6 PLD4 NCKAP1L

6.58e-051371375587a369b148bb2600c06db39298feddfc99cb6ad
ToppCellfacs-Marrow-B-cells-24m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 NPBWR1 PAQR5 NRXN2 PLD4

9.19e-0514713759d7e965fe61bd7b31e09c4b2129a5a98c36f4811
ToppCellfacs-Marrow-B-cells-24m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 NPBWR1 PAQR5 NRXN2 PLD4

9.19e-05147137538552953ff65a0fc20bee6ef57dc5885306ad18b
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Lgi2_(Golgi_interneuron)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

FSIP2 P2RY2 NPC1L1 ACCSL

9.37e-05771374afe990041849a68fd75e0c11b633a7b90fefade1
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Lgi2_(Golgi_interneuron)|Cerebellum / BrainAtlas - Mouse McCarroll V32

FSIP2 P2RY2 NPC1L1 ACCSL

9.37e-05771374ec8f625cae561986ed27dfaefa8f822dd1c4fba1
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Lgi2_(Golgi_interneuron)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

FSIP2 P2RY2 NPC1L1 ACCSL

9.37e-05771374af7e1e76db33b115238b6fc61fc0dd86aab8e49d
ToppCellLPS_only-Myeloid-Dendritic_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TASL ATP13A2 TLR10 PLD4 NCKAP1L

9.48e-051481375cb9365663f9cba35d47b5dd9079f42e88b70d915
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA12 DYNC2H1 GPRC6A SLC9A2 NFE2L2

1.11e-0415313759b6675ace8a83c8d446b722301d0ec4e6840f3fc
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA12 DYNC2H1 GPRC6A SLC9A2 NFE2L2

1.25e-0415713752c5295043611bac7dfa4aef2146681bce4a33a8f
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TGFB1 TMEM143 PLXNA1 PLD4 NCKAP1L

1.33e-0415913750c2437da5443fc3aff66f8ef311f02aa434a1fb0
ToppCellControl-Myeloid-Monocytes,_Macrophages-Mast-cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KLHL6 CPA3 TASL DOCK5 C1QTNF1

1.33e-04159137581782e9e370558d61af5e0c760ac9759d69fb725
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal|GW19 / Sample Type, Dataset, Time_group, and Cell type.

PHF8 DNAH17 PIGW ELF3 CATSPERG

1.33e-041591375f34f2729a3872fbb2939e76ad35d7e25f71b8f57
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal-Unfolded_protein_responsible_cell|GW19 / Sample Type, Dataset, Time_group, and Cell type.

PHF8 DNAH17 PIGW ELF3 CATSPERG

1.33e-041591375929ed98f6c2ad14e8d5af5c6f11a5a3d4b388cf7
ToppCellprimary_visual_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Ctla2a|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KLHL6 PECAM1 PAQR5 EPAS1 FOXF2

1.41e-041611375a60ef3f390f56bb05b687b17986fe6382f69f260
ToppCellprimary_visual_cortex-Non-neuronal-endothelial_cell-Endo|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KLHL6 PECAM1 PAQR5 EPAS1 FOXF2

1.45e-0416213750bdb1e5ba33e162bec1acb28256c1405a7658ee5
ToppCellprimary_visual_cortex-Non-neuronal-endothelial_cell|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KLHL6 PECAM1 PAQR5 EPAS1 FOXF2

1.45e-0416213755799a602ef8d83925907e8e34532428be7330228
ToppCell343B-Fibroblasts-Fibroblast-D-|343B / Donor, Lineage, Cell class and subclass (all cells)

ARSI NRXN2 C1QTNF1 CYP4F12 BICC1

1.49e-0416313758d2b2119c6b3d5b677da6f377fd85146590e1246
ToppCellE12.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PECAM1 SIPA1 PTPN18 TGFB1 UNC13A

1.49e-041631375c21114826bee1b05b411984326fef6b6e0d05316
ToppCellE12.5-Endothelial-lymphatic_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PECAM1 SIPA1 PTPN18 TGFB1 UNC13A

1.49e-0416313755d49414432db259a19df50d7944581d00b69f537
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UBR1 GPR21 PCDHA8 NEK9 ZBED4

1.49e-041631375132aece9c79499b4bb3c2bde68d3d7202e1d8772
ToppCell343B-Fibroblasts-Fibroblast-D|343B / Donor, Lineage, Cell class and subclass (all cells)

ARSI NRXN2 C1QTNF1 CYP4F12 BICC1

1.49e-041631375acfb2ece6202479e615d54fd3ecb8b4a571b5a18
ToppCellfrontal_cortex-Non-neuronal-endothelial_cell|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KLHL6 PECAM1 PAQR5 EPAS1 FOXF2

1.53e-0416413756a41a159134e605b80d5e731f9ed5bc803bb531b
ToppCellfrontal_cortex-Non-neuronal-endothelial_cell-Endo|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KLHL6 PECAM1 PAQR5 EPAS1 FOXF2

1.53e-041641375ec68954fc09b6850273b5e59caa6b09d02151097
ToppCellfacs-Aorta-Heart-3m-Mesenchymal-fibrocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN18 PGAP6 OPRD1 PLD4 NCKAP1L

1.58e-0416513758a52f2dbcbd2bc1662b5e3fac381463fdcc3bf14
ToppCellwk_15-18-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor_intermediate_|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

OPRK1 GREB1L ARFGEF3 GPR75 ELF3

1.58e-041651375f6887c64af0f26e33316bc5587487e24d76ece2a
ToppCellfrontal_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Ctla2a|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KLHL6 PECAM1 PAQR5 EPAS1 FOXF2

1.62e-04166137527af6c906cff1d40d134f0386db7708869691121
ToppCellControl|World / group, cell type (main and fine annotations)

UNC13B ARFGEF3 NRXN3 P3H2 ELF3

1.72e-041681375a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCelldroplet-Pancreas-PANCREAS-30m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL6 PTPN18 TGFB1 PLD4 NCKAP1L

1.72e-0416813755946204d42307391bc2160abe12850815f350aea
ToppCell356C-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PAQR5 TGFB1 SESN2 STEAP1B CLUH

1.76e-0416913750425d2580ed325178f522c0093ff4623de6ce7a8
ToppCelldroplet-Spleen-nan-21m-Myeloid-macrophage_dendritic_cell_progenitor|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 CDS1 PAQR5 NRXN2 TNS1

1.76e-0416913757962165cab84af73d20b56eb70b1ed87c94025ef
ToppCell3'-Child09-12-SmallIntestine-Epithelial-Tuft-related-Tuft|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCDC14 MYT1 PTPN18 GPR75 ELF3

1.76e-04169137505e12524d68d409fed386ffad233305683b4575b
ToppCell356C-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PAQR5 TGFB1 SESN2 STEAP1B CLUH

1.76e-041691375fec669968a77060bd77ee8695034e35a642c984f
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TASL OPRK1 TLR10 SLC20A1 PLD4

1.81e-041701375b49f7c8a27078de2137ed04f74cfee30729cfa5e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYT1 SLC35B3 FSIP2 P3H2 DNAH17

1.81e-0417013755d5f208682be21ed58320f5fc083a7898f8712da
ToppCellLPS-antiTNF-Myeloid-Dendritic_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KLHL6 TASL TLR10 PLD4 NCKAP1L

1.81e-0417013753cbeea6bfa500928c413b1c6129f6dedc769cd1e
ToppCellfacs-Marrow-T-cells-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 PAQR5 NRXN2 TNS1 PLD4

1.86e-0417113756a0fafb8fd9fc7671618eeb2bf528ce8ce86b794
ToppCell5'-Adult-LargeIntestine-Epithelial-goblet-Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCDC14 PLK2 ARFGEF3 ELF3 CATSPERG

1.86e-04171137548125d825ca2d7ef34564250f5b47d2a579e03c9
ToppCellCOVID_vent-Lymphocytic-Dendritic-pDC|COVID_vent / Disease condition, Lineage, Cell class and subclass

NPC1 LRRK1 ATP13A2 P3H2 PLD4

1.86e-041711375779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCellCOVID_vent-Lymphocytic-Dendritic|COVID_vent / Disease condition, Lineage, Cell class and subclass

NPC1 LRRK1 ATP13A2 P3H2 PLD4

1.86e-041711375debbb071d260639b16269c94d172766908325c58
ToppCellfacs-Marrow-T-cells-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 PAQR5 NRXN2 TNS1 PLD4

1.86e-041711375e02b5831768dbb1b68998b672e55c9680ab0cc86
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TASL OPRL1 IQGAP3 PLD4 NCKAP1L

1.86e-04171137555c7bf7211587fa08df13c0a4ff5b78a85d5439e
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-D_cells_(SST+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYT1 SLC12A5 ARFGEF3 EPHX3 UNC13A

1.86e-041711375fa5cc720bd0045d0307439be547b41d56def5b43
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 DOCK5 SRGAP2C PTPRQ SRGAP2B

1.92e-0417213756c17a1e586a72d1bd80c20c06370429c61dc9f85
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 DOCK5 SRGAP2C PTPRQ SRGAP2B

1.92e-041721375381ae1c3c07d0a424f43455ec571653b192a946a
ToppCelldroplet-Spleen-SPLEEN-30m-Myeloid-macrophage_dendritic_cell_progenitor|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 CDS1 PAQR5 ARFGEF3 NRXN2

1.92e-04172137530916a902c151907745756d14327e24adc34afef
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PECAM1 PAQR5 TGFB1 FCSK USP38

1.92e-0417213758a6a2b4c6654bc976e60a02d0e7303a9071ed55f
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TGFB1 SLC20A1 TMEM143 PLXNA1 PLD4

1.97e-04173137520f7dfe7d92a3dbec9da9a1f3185aa10cb8f0a3c
ToppCelldroplet-Thymus-nan-18m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAQR5 CPA3 C1QTNF1 EPHX3 PLD4

1.97e-0417313755d7c53c6d1cdd385e44b79b82faec901747d1736
DrugAC1L1DSH

PLK2 IDE OPRD1 OPRK1 OPRL1

7.13e-08191345CID000002487
DrugNSC11411

OPRD1 OPRK1 OPRL1

1.99e-0731343CID000408117
DrugRo 64-6198

OPRD1 OPRK1 OPRL1

1.99e-0731343CID009844019
DrugAC1L1I4J

IDE OPRD1 OPRK1 OPRL1

3.67e-07111344CID000004419
Drugetonitazene

IDE OPRD1 OPRK1 OPRL1

7.87e-07131344CID000013493
Drugmetkephamid acetate

OPRD1 OPRK1 OPRL1

1.98e-0651343CID005464183
DrugR-84760

OPRD1 OPRK1 OPRL1

1.98e-0651343CID000133035
DrugDALECK

OPRD1 OPRK1 OPRL1

1.98e-0651343CID015942760
DrugGPA 1657

OPRD1 OPRK1 OPRL1

1.98e-0651343CID000030503
DrugRLH-033

OPRD1 OPRK1 OPRL1

1.98e-0651343CID000190867
DrugMr2097

OPRD1 OPRK1 OPRL1

1.98e-0651343CID005745592
DrugAC1L2FKQ

OPRD1 OPRK1 OPRL1

1.98e-0651343CID000020114
DrugTyr-tic-phe-phe-OH

OPRD1 OPRK1 OPRL1

1.98e-0651343CID003035452
DrugICI 197067

OPRD1 OPRK1 OPRL1

1.98e-0651343CID003081077
Drugmirfentanil

OPRD1 OPRK1 OPRL1

1.98e-0651343CID000060697
DrugBRL 52537

OPRD1 OPRK1 OPRL1

1.98e-0651343CID005244802
DrugAC1L1TDW

OPRD1 OPRK1 OPRL1

1.98e-0651343CID000060509
DrugEtorphine

OPRD1 OPRK1 OPRL1

3.94e-0661343DB01497
DrugNIH10236

OPRD1 OPRK1 OPRL1

3.94e-0661343CID006439828
DrugAC1L2OET

OPRD1 OPRK1 OPRL1

3.94e-0661343CID000125331
DrugAC1L3OP4

OPRD1 OPRK1 OPRL1

3.94e-0661343CID000092720
Drugbeta-methyl-2',6'-dimethyltyrosine

OPRD1 OPRK1 OPRL1

3.94e-0661343CID000189865
DrugNSC612111

OPRD1 OPRK1 OPRL1

3.94e-0661343CID000163346
DrugAC1L1FBI

OPRD1 OPRK1 OPRL1

3.94e-0661343CID000053641
DrugKT-90

OPRD1 OPRK1 OPRL1

3.94e-0661343CID005492465
DrugRX8008M

OPRD1 OPRK1 OPRL1

3.94e-0661343CID000162443
DrugAC1L2TFU

OPRD1 OPRK1 OPRL1

3.94e-0661343CID000128241
DrugDuP 747

OPRD1 OPRK1 OPRL1

3.94e-0661343CID000132447
Drug6-monoacetylmorphine

GCDH OPRD1 OPRK1 OPRL1

6.35e-06211344CID000520352
DrugTyr-ala-phe-gly

OPRD1 OPRK1 OPRL1

6.86e-0671343CID005487532
DrugGR89696

OPRD1 OPRK1 OPRL1

6.86e-0671343CID000003505
DrugEET-HO

OPRD1 OPRK1 OPRL1

6.86e-0671343CID000135928
DrugMET-CAMO

OPRD1 OPRK1 OPRL1

6.86e-0671343CID006450159
Drugphenylmorphan

OPRD1 OPRK1 OPRL1

6.86e-0671343CID000146306
DrugAC1Q6ZKG

OPRD1 OPRK1 OPRL1

6.86e-0671343CID000031785
DrugAC1L9PCU

OPRD1 OPRK1 OPRL1

6.86e-0671343CID000451042
DrugN-cyclopropylmethylnorazidomorphine

OPRD1 OPRK1 OPRL1

6.86e-0671343CID005489191
Drug2-mercaptoacetate

OPRD1 OPRK1 OPRL1

6.86e-0671343ctd:C017487
DrugAC1L2YDY

OPRD1 OPRK1 OPRL1

6.86e-0671343CID000130992
Drugbeta-naltrexamine

OPRD1 OPRK1 OPRL1

6.86e-0671343CID005486948
DrugICI-199,441

OPRD1 OPRK1 OPRL1

6.86e-0671343CID003082717
DrugNDTMB

OPRD1 OPRK1 OPRL1

6.86e-0671343CID000134748
DrugAC1L1I4V

IDE OPRD1 OPRK1 OPRL1

7.73e-06221344CID000004423
DrugAC1Q1ZY1

OPRD1 OPRK1 OPRL1

1.09e-0581343CID000065964
DrugICI 204448

OPRD1 OPRK1 OPRL1

1.09e-0581343CID000003683
Drugphenazocine

OPRD1 OPRK1 OPRL1

1.09e-0581343CID000014706
Drugmetazocine

OPRD1 OPRK1 OPRL1

1.09e-0581343CID000062518
DrugAC1L1B1Q

OPRD1 OPRK1 OPRL1

1.09e-0581343CID000001246
DrugDIPPA

OPRD1 OPRK1 OPRL1

1.09e-0581343CID000127914
Drugdioxadrol

OPRD1 OPRK1 OPRL1

1.09e-0581343CID000066269
DrugTyr-D-Ala-Gly-Phe-Leu-chloromethyl ketone

OPRD1 OPRK1 OPRL1

1.09e-0581343CID005492572
DrugAC1L2Y8M

OPRD1 OPRK1 OPRL1

1.09e-0581343CID000130908
Drug14-methoxymetopon

OPRD1 OPRK1 OPRL1

1.09e-0581343CID005486940
DrugKT-89

OPRD1 OPRK1 OPRL1

1.09e-0581343CID005748450
Drugbinaltorphimine

OPRD1 OPRK1 OPRL1

1.09e-0581343CID005484197
DrugN-methyl nalorphine

OPRD1 OPRK1 OPRL1

1.09e-0581343CID005748235
DrugAC1LBBLW

OPRD1 OPRK1 OPRL1

1.09e-0581343CID000579851
DrugOxymorphone hydrazone

OPRD1 OPRK1 OPRL1

1.09e-0581343CID009577748
DrugB-Ni

OPRD1 OPRK1 OPRL1 TNR

1.32e-05251344CID000446236
DrugAC1Q5SQW

IDE OPRD1 OPRK1 OPRL1

1.32e-05251344CID000003912
DrugDalamide

OPRD1 OPRK1 OPRL1 HPS4

1.55e-05261344CID000100169
DrugDam K

OPRD1 OPRK1 OPRL1

1.63e-0591343CID005487344
DrugAC1Q7A0V

OPRD1 OPRK1 OPRL1

1.63e-0591343CID000001250
Drugmeptazinol

OPRD1 OPRK1 OPRL1

1.63e-0591343CID000041049
DrugSyndyphalin

OPRD1 OPRK1 OPRL1

1.63e-0591343CID000174117
DrugAC1LD4H9

OPRD1 OPRK1 OPRL1

1.63e-0591343CID000611919
DrugM 285

OPRD1 OPRK1 OPRL1

1.63e-0591343CID000020435
DrugMRZ 2549

OPRD1 OPRK1 OPRL1

1.63e-0591343CID000134837
Drug6-benzal-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one

OPRD1 OPRK1 OPRL1 HPS4

1.81e-05271344CID005149021
DrugAC1L3X5D

OPRD1 OPRK1 OPRL1 HPS4

1.81e-05271344CID000123704
DrugTgg Tripeptide

OPRD1 OPRK1 OPRL1 HPS4

1.81e-05271344CID000123715
DrugSKF 10,047

OPRD1 OPRK1 OPRL1 HPS4

1.81e-05271344CID000001235
DrugAC1LCF1O

OPRD1 OPRK1 OPRL1

2.32e-05101343CID000627285
Drugnormetazocine

OPRD1 OPRK1 OPRL1

2.32e-05101343CID000001208
Drugme fit

OPRD1 OPRK1 OPRL1

2.32e-05101343CID000127921
Drugprofadol

OPRD1 OPRK1 OPRL1

2.32e-05101343CID000009882
DrugBd 737

OPRD1 OPRK1 OPRL1

2.32e-05101343CID000131252
DrugNaloxone-6-hydrazone

OPRD1 OPRK1 OPRL1

2.32e-05101343CID009576788
DrugDrofenine hydrochloride [548-66-3]; Down 200; 11.4uM; HL60; HT_HG-U133A

DYNC2H1 PLPPR3 NEK9 SULT1B1 GPR75 TNS1 USP6NL EPAS1

2.32e-0519813482714_DN
DrugTyr-gly-gly-phe

OPRD1 OPRK1 OPRL1 HPS4

2.79e-05301344CID006453937
DrugPD117302

OPRD1 OPRK1 OPRL1

3.18e-05111343CID000122115
DrugTrimu-5

OPRD1 OPRK1 OPRL1

3.18e-05111343CID005487273
DrugWy-16,225

OPRD1 OPRK1 OPRL1

3.18e-05111343CID000040841
Druglofexidine

OPRD1 OPRK1 OPRL1

3.18e-05111343CID000030667
DrugAC1MI02C

OPRD1 OPRK1 OPRL1

3.18e-05111343CID003035838
DrugO-desmethyltramadol

OPRD1 OPRK1 OPRL1

3.18e-05111343CID000130829
DrugAC1MICD4

OPRD1 OPRK1 OPRL1

3.18e-05111343CID003021990
DrugAC1LCENG

OPRD1 OPRK1 OPRL1

3.18e-05111343CID000626667
DrugSNC80

IDE OPRD1 OPRK1 OPRL1

3.19e-05311344CID000123924
Drugdl-Bremazocine

NPBWR1 OPRD1 OPRK1 OPRL1

3.19e-05311344CID000001223
DrugAC1L1I5D

OPRD1 OPRK1 OPRL1 HPS4

3.19e-05311344CID000004429
DrugU-54494A

IDE OPRK1

3.44e-0521342CID000122015
Drugerinacine E

OPRD1 OPRK1

3.44e-0521342CID005317180
DrugN-butyrylhomoserine lactone

P2RY2 P2RY4

3.44e-0521342ctd:C092312
DrugDynorphin (1-11)

OPRD1 OPRK1

3.44e-0521342CID003086114
Drug(-)-EKC

OPRD1 OPRK1

3.44e-0521342CID000042800
Drug2-aminooxazole

OPRD1 OPRK1

3.44e-0521342CID000558521
DrugMR-1353

OPRD1 OPRK1

3.44e-0521342CID000197198
Drugtrefentanil

OPRD1 OPRK1

3.44e-0521342CID000060727
DrugTedam

OPRD1 OPRK1 OPRL1

4.22e-05121343CID000124900
DiseaseNiemann-Pick disease type C1 (implicated_via_orthology)

NPC1 NPC1L1

1.90e-0521292DOID:0070113 (implicated_via_orthology)
Diseasealcohol use disorder (implicated_via_orthology)

UNC13B GPR21 GPR52 OPRL1 ADH5 ARID2 UNC13A

2.50e-051951297DOID:1574 (implicated_via_orthology)
Diseasebilirubin measurement

UBR1 MYT1 TMC6 PGAP6 ADH5 PPP2R3A SCAP NGEF STEAP1B ASAH2B

2.59e-0544212910EFO_0004570
DiseaseParkinson's disease (implicated_via_orthology)

NPBWR1 LRRK1 ATP13A2 OPRD1 OPRK1 OPRL1

6.84e-051571296DOID:14330 (implicated_via_orthology)
DiseaseNiemann-Pick disease (implicated_via_orthology)

NPC1 NPC1L1

1.13e-0441292DOID:14504 (implicated_via_orthology)
Diseasecoronary artery disease

NPC1 TTC41P DYNC2H1 PECAM1 HECTD4 SIPA1 NEK9 TGFB1 DOCK5 PPP2R3A GPR149 C1QTNF1 TNS1 UNC13A BICC1

2.34e-04119412915EFO_0001645
Diseasepulse pressure measurement

NPC1 DYNC2H1 MYT1 PECAM1 PCDHA8 SIPA1 NEK9 OPRL1 TGFB1 FCSK NFE2L2 UGT2A1 ACCSL STEAP1B CNOT1 BICC1

3.87e-04139212916EFO_0005763
DiseaseAutism Spectrum Disorders

NLGN3 NRXN3 NRXN2 IQGAP3

5.37e-04851294C1510586
DiseaseHepatic Insufficiency

TGFB1 NFE2L2

6.69e-0491292C1306571
Diseasemyocardial infarction

DYNC2H1 PECAM1 HECTD4 TGFB1 PPP2R3A C1QTNF1 TNS1

9.03e-043501297EFO_0000612
Diseasechildhood trauma measurement, smoking behaviour measurement

NPBWR1 OPRK1 NRXN3

1.01e-03451293EFO_0005671, EFO_0007979
Diseasepulmonary fibrosis (implicated_via_orthology)

TGFB1 NFE2L2

1.22e-03121292DOID:3770 (implicated_via_orthology)
DiseaseEpilepsy

OPRD1 SLC12A5 TGFB1 KCND2

1.36e-031091294C0014544
Diseasecoronary artery disease, factor VII measurement

DYNC2H1 TGFB1 ADH5 GPR149

1.46e-031111294EFO_0001645, EFO_0004619
Diseasesickle cell anemia (is_marker_for)

PECAM1 TGFB1

1.67e-03141292DOID:10923 (is_marker_for)
DiseaseHepatomegaly

TGFB1 NFE2L2 SESN2

1.72e-03541293C0019209
Diseasevon Willebrand factor measurement, coronary artery disease

DYNC2H1 HECTD4 TGFB1 GPR149

1.82e-031181294EFO_0001645, EFO_0004629
Diseasemetabolic syndrome

NPC1 HECTD4 SIPA1 OPRL1 PPP2R3A

1.90e-032001295EFO_0000195
DiseaseWithdrawal Symptoms

OPRD1 OPRK1 OPRL1

2.11e-03581293C0087169
DiseaseDrug Withdrawal Symptoms

OPRD1 OPRK1 OPRL1

2.11e-03581293C0086189
DiseaseSubstance Withdrawal Syndrome

OPRD1 OPRK1 OPRL1

2.11e-03581293C0038587
Diseasefibrinogen measurement, factor VII measurement

HECTD4 ADH5 PPP2R3A

2.11e-03581293EFO_0004619, EFO_0004623
Diseasereticulocyte count

PLK2 TMC6 HECTD4 PLPPR3 GCDH SIPA1 SLC12A5 GREB1L DOCK5 P2RY2 DNAH17 TNS1

2.15e-03104512912EFO_0007986
DiseaseSchizoaffective disorder-bipolar type

MYT1 NRXN3

2.19e-03161292EFO_0009965
Diseaserenal fibrosis (implicated_via_orthology)

GPR21 GPR52

2.47e-03171292DOID:0050855 (implicated_via_orthology)
Diseaseserum IgE measurement

NPBWR1 OPRK1 SIPA1L2

2.80e-03641293EFO_0004579
Diseasebitter alcoholic beverage consumption measurement

NPC1 NRXN2 KCND2 RMC1

2.81e-031331294EFO_0010092
Diseasemyocardial infarction (implicated_via_orthology)

OPRD1 OPRK1 NFE2L2

3.06e-03661293DOID:5844 (implicated_via_orthology)
Diseasepulmonary non-tuberculous mycobacterial infection

SCAP C3orf85

3.09e-03191292MONDO_0018469
DiseaseNonorganic psychosis

GPR52 ST3GAL1 TGFB1

3.47e-03691293C0349204
DiseaseLeft Ventricle Remodeling

TGFB1 NFE2L2

3.77e-03211292C0600520
DiseaseVentricular Remodeling

TGFB1 NFE2L2

3.77e-03211292C0600519
Diseasecardiovascular disease

NPC1 PAQR5 OPRL1 USP38 NPC1L1 SIPA1L2 BICC1

4.05e-034571297EFO_0000319
DiseaseAcute Lung Injury

TGFB1 NFE2L2

4.14e-03221292C0242488

Protein segments in the cluster

PeptideGeneStartEntry
YRFLYHTVAQMFCST

PTPN18

281

Q99952
VMSTLLANINAYYAH

UNC13A

896

Q9UPW8
YMLSVFDESITFHSI

ACCSL

361

Q4AC99
YFHSNGSEYIMALTT

CATSPERG

351

Q6ZRH7
SAYEFYHALDSENMT

EPAS1

276

Q99814
MHVTSQSLLSIYSYG

ACTL7B

176

Q9Y614
DCQYLMATFVHVYIT

CDS1

401

Q92903
LSHYMSINDSFYTSH

BICD2

261

Q8TD16
AYLYQHSSTTMLSGV

C2orf78

96

A6NCI8
MSVDYISFSAHTDYQ

CPSF3

386

Q9UKF6
HDTTSYSFYMQRIKH

BTBD16

411

Q32M84
YSFYMQRIKHTDLES

BTBD16

416

Q32M84
TILHYMGTSTFSEYT

ADH5

136

P11766
QYSTMLYAQRASHIL

ARSI

206

Q5FYB1
FSDYSFSVIAMSYLI

ABCA12

1151

Q86UK0
QFMDRTHYLLTFSSS

ASAH2B

6

P0C7U1
LTYHSERTVTFTYVM

GPR12

146

P47775
HSVSDYLRQSYGLSM

ARID2

136

Q68CP9
IVSYFNHMSASILPY

ACOT12

506

Q8WYK0
EISNIFSNYFSAMYS

ELF3

6

P78545
TTAQYYLDMNTFTFD

C3orf85

71

A0A1B0GTC6
QNKSTEHYLSSSNYM

BICC1

841

Q9H694
EHYLSSSNYMDCISS

BICC1

846

Q9H694
MSYLNKLETNYSFTH

CCDC14

691

Q49A88
DALMCTTFHDYYVAL

PAQR5

141

Q9NXK6
FLSHLAIVDMSYASS

OR2A12

61

Q8NGT7
SVLTYRLSSHDYFML

PCDHA8

166

Q9Y5H6
YSYISLTAMAIQHSA

FOXB2

16

Q5VYV0
VHKSVMASCSEYFYN

KLHL31

86

Q9H511
ETMHTLLDYTYTSKA

KLHL6

121

Q8WZ60
ITLYQMASQSSASHY

M1AP

291

Q8TC57
SVYSFLFLYLRMHQT

DOLPP1

111

Q86YN1
IIAYYNHFMDNTTLL

NEK9

111

Q8TD19
DKANSLVMYHSTTYQ

LRRK1

1756

Q38SD2
LMVSSSYYSIGHSQD

HECW1

81

Q76N89
TYNFTHYDRIQSLLM

HPS4

601

Q9NQG7
THYFIHRIMSSSSYN

FSIP2

6786

Q5CZC0
FNSMSALHEIYSYIT

PLXNA1

1846

Q9UIW2
FSQAYFIHTLSVMES

OR51B6

96

Q9H340
LFYNISSMKSTESYF

PECAM1

81

P16284
TEVDNYHFYSSIPSM

NFE2L2

221

Q16236
VPIHDTISSYFMNYN

ENPP4

141

Q9Y6X5
SSYLALATLQAYASM

NRXN2

926

Q9P2S2
YLSLATLQAYTSMHL

NRXN3

881

Q9Y4C0
LALTMNHVYSFSVFE

NCKAP1L

686

P55160
ENPHTSTMALVFYYV

KCND2

176

Q9NZV8
LVEASVYAYTMFFST

PGAP6

571

Q9HCN3
SHLHTTMYYFLTNLS

OR10G8

51

Q8NGN5
FYTYMLRSSYHTAEQ

OR2T34

261

Q8NGX1
IVESYFMLNSTLYFS

P3H2

541

Q8IVL5
TLYFSYTHMVCRTAL

P3H2

551

Q8IVL5
TMSTVHLSSDGTYFY

HECTD4

11

Q9Y4D8
AAASAYNYAEQTMSH

RBM4B

236

Q9BQ04
LHHYTTSYFIQTMAY

GPR52

71

Q9Y2T5
VSIMLTKYAAYNTFH

GREB1L

1426

Q9C091
MAATYRLVVSTVNHY

PPP2R3A

1

Q06190
YMFHLAVSDALYAAS

P2RY2

71

P41231
SYIAMHYHTTNDLVQ

GPR75

511

O95800
MEAVIFSLYNYASSR

IQGAP3

986

Q86VI3
SIDYYNMFTSIFTLT

OPRD1

126

P41143
HMYTFIKLLANTSYV

PTPRQ

1431

Q9UMZ3
KMIYSYSSHSVSSIA

GPRC6A

851

Q5T6X5
LKATLLVSYNFYTMH

GPR149

121

Q86SP6
TRVGATYFMTYHTVL

NPC1

1031

O15118
TYFMTYHTVLQTSAD

NPC1

1036

O15118
ATYMFHLALSDTLYV

P2RY4

71

P51582
YASVMEYFPTTRFSH

PLD4

336

Q96BZ4
NLYLLDSTSRFMAYH

NPC1L1

1066

Q9UHC9
LYNLHDMFHYTSTTT

NLGN3

631

Q9NZ94
SSYTSDNDMIVSIFY

OR5T1

276

Q8NG75
LFYYVAVSLMSHQTL

PDP2

156

Q9P2J9
YSYMTSSASEFLLSL

FCSK

326

Q8N0W3
RYMTFLHVYSAISSS

DYNC2H1

2871

Q8NCM8
SLDTSFSVFKYMALY

ATP13A2

926

Q9NQ11
EIKVYITFHSYSQML

CPA3

296

P15088
MHSNHYYQTVIFDTE

C1QTNF1

156

Q9BXJ1
LQQMDDSHYSHYIST

DOCK5

961

Q9H7D0
SISFFMSYVHTTVNE

DNAH17

2986

Q9UFH2
METRAHYNSSNKSYT

GCDH

191

Q92947
TYDVHFYASFALIML

GBA2

536

Q9HCG7
SHYSEMLAFTLTAFL

ELMO2

141

Q96JJ3
LLVLHASFSYMDSYN

DCST1

386

Q5T197
LYRQSAMSFNIYFHA

ARFGEF3

1806

Q5TH69
SQHILQHMDFLYYLS

CYP4F12

236

Q9HCS2
LVSLHISQYYFMSSC

ELOVL1

211

Q9BW60
MSVYQDYSLHHISQF

EPHX3

201

Q9H6B9
LLKFHSAYYSSNLMA

IDE

241

P14735
HHTTSYFIQTMAYAD

GPR21

61

Q99679
MVSYTITLVFQHYHA

SCAP

231

Q12770
MDSYTSYCNAVSDLH

SLC20A1

461

Q8WUM9
DQYNTFSSLYFLTVM

NPBWR1

116

P48145
DHPYVFSDMTSYFTL

SLC12A5

411

Q9H2X9
SIDYYNMFTSIFTLT

OPRK1

136

P41145
VIAIDYYNMFTSTFT

OPRL1

126

P41146
MSSYSLEQSYLHQNA

FOXF2

371

Q12947
TTTDYHTLVANYMSG

GPRASP1

1266

Q5JY77
YSLTYNTIAMHSGVD

SESN2

371

P58004
YLDHNSFDYSNTVMR

TLR10

286

Q9BXR5
PEMLASYQSYSSTFH

NBPF15

301

Q8N660
PEMLASYQSYSSTFH

NBPF19

301

A0A087WUL8
QMTDLYHYITSYVVH

PSG6

71

Q00889
IESLSDSTIYMAFYT

LARS1

591

Q9P2J5
DSTIYMAFYTVAHLL

LARS1

596

Q9P2J5
ASYYKSLNLLVSHFM

NGEF

286

Q8N5V2
THSLYTTYKDYELMF

SIPA1L2

666

Q9P2F8
TTYKDYELMFHVSTL

SIPA1L2

671

Q9P2F8
LTSFFLNYSHTMVAT

ST3GAL1

21

Q11201
YTTYQDHEIMFHVST

SIPA1

396

Q96FS4
KLHNASNSEMVLYSY

SLC35B3

251

Q9H1N7
TYHMYNADSISAQSK

SRGAP2C

166

P0DJJ0
TYHMYNADSISAQSK

SRGAP2B

166

P0DMP2
FYGVSSQYESLEHMT

TEAD2

326

Q15562
VSVSYYHFDLMNNLQ

SULT1B1

136

O43704
MEGSKLHYFTNSLYS

PIGW

191

Q7Z7B1
FFAVLHAIYTLSYAM

STEAP1B

151

Q6NZ63
TIQEYMHLALYCFAS

CLUH

1061

O75153
THYFSCTMLYLFAEA

CNOT1

2281

A5YKK6
AAFAAVYVSMYFNST

PLPPR4

256

Q7Z2D5
QHLDSQEIYTSFYTM

USP6NL

251

Q92738
LELAHMLYYRSTSNN

TMEM143

336

Q96AN5
LYSYLSYITAEMFHL

SLC9A2

316

Q9UBY0
YMLHQFLQYHVLSDS

RMC1

516

Q96DM3
SAFAAVYVSMYFNSV

PLPPR3

211

Q6T4P5
LYKQYIMDTVFHDSS

TASL

221

Q9HAI6
MTHVASQFASSYVFY

THG1L

126

Q9NWX6
QSTHSIYMFFNTSEL

TGFB1

126

P01137
TYHMYNADSISAQSK

SRGAP2

166

O75044
AYMHYSNISASADQA

TNS1

126

Q9HBL0
LLPSTHYTATMYATN

TNR

1011

Q92752
YSSAFASSTNAYMLI

USP47

546

Q96K76
SSYNHLYLFHLITMA

UBR1

1431

Q8IWV7
CESSYIMSVIHYFIT

TTC41P

376

Q6P2S7
MSTLLANINAYYAHT

UNC13B

821

O14795
SYQMYHQSEALALAS

USP38

871

Q8NB14
LSYNLMDTYSHQALK

PHF8

556

Q9UPP1
ITLVYSMAHSFGESY

TMC6

356

Q7Z403
ISQVTVLKYFSHYME

PLK2

566

Q9NYY3
FEYMSYLQRHSITHS

ZNF581

96

Q9P0T4
DDSVLHLTFYYLMNL

THOC5

356

Q13769
VSVYYSHVLQMLFFS

UBR4

2111

Q5T4S7
RNFISYHLQDYMFET

UGT2A1

211

P0DTE4
LFSQYSSTLYDVAME

ZBED4

86

O75132
NFDAYVSTLTDMYSN

MYT1

1086

Q01538